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Assessing The Impact Of Visitors On Airborne Particle Deposition In The Giant Gypsum Geode Of Pulpí (Se Spain), Ana Camila Mendoza, Ángel Fernández-Cortés, Fernando Gázquez, Jesús Morilla, Milagros Carretero, Jose Maria Calaforra, David Benavente Jan 2026

Assessing The Impact Of Visitors On Airborne Particle Deposition In The Giant Gypsum Geode Of Pulpí (Se Spain), Ana Camila Mendoza, Ángel Fernández-Cortés, Fernando Gázquez, Jesús Morilla, Milagros Carretero, Jose Maria Calaforra, David Benavente

International Journal of Speleology

The Giant Geode of Pulpí is a unique mineralogical phenomenon worldwide, remarkable for its large selenite gypsum crystals. Its recent development as a tourist site and inclusion on UNESCO’s Tentative World Heritage List, highlight the need to assess the impact of visits on its conservation. This study investigates airborne particle dynamics inside the Geode, focusing on tourist activity and natural ventilation. We measured deposition rates and composition of airborne particles using passive traps and a continuous laser-optical particle counter. Microenvironmental variables linked to ventilation, such as temperature and radon gas concentration (²²²Rn), were simultaneously monitored. Results show a predominance of …


Optimized Photoemission From Organic Molecules In 2d Layered Halide Perovskites, Muhammad S. Muhammad, Dilruba A. Popy, Hamza Shoukat, John M. Lane, Neeraj Rai, Vojtěch Vaněček, Zdeněk Remeš, Romana Kučerková, Vladimir Babin, Chenjia Mi, Yitong Dong, Mark D. Smith, Novruz G. Akhmedov, Daniel T. Glatzhofer, Bayram Saparov Jan 2026

Optimized Photoemission From Organic Molecules In 2d Layered Halide Perovskites, Muhammad S. Muhammad, Dilruba A. Popy, Hamza Shoukat, John M. Lane, Neeraj Rai, Vojtěch Vaněček, Zdeněk Remeš, Romana Kučerková, Vladimir Babin, Chenjia Mi, Yitong Dong, Mark D. Smith, Novruz G. Akhmedov, Daniel T. Glatzhofer, Bayram Saparov

Faculty Publications

In recent years, hybrid organic–inorganic metal halides have been at the forefront of materials research. Typically, the functional (e.g., optoelectronic) properties of hybrid halides are derived from the inorganic structural part, whereas the organic structural units can add extra advantages in terms of stability, rigidity, and processability. Here, we report the design, synthesis, and characterization of two new hybrid materials in which the outstanding photophysical properties originate from the organic structural part. The new compounds, (C15H16N)2CdCl4 and((Br)C15H15N)2CdCl4, have 2D layered Ruddlesden–Popper-type perovskite structures. These hybrids are blue-white …


Environmental Degradations In Images: Analysis, Restoration, And Applications, Harsh Bhandari Jan 2026

Environmental Degradations In Images: Analysis, Restoration, And Applications, Harsh Bhandari

Doctoral Theses

This thesis investigates computational models and methodologies for restoring images degraded by challenging environmental conditions such as haze and underwater environments. It further explores the analysis and estimation of particulate matter (PM) concentration from both day and night scenes under varying weather conditions, using degraded visual data as a primary input. Each environment introduces distinct forms of visual degradation, making image restoration a critical challenge that directly impacts applications including visibility enhancement, weather analysis, particulate concentration estimation, and object detection. By addressing these challenges, this thesis aims to develop adaptable, data-driven solutions that enhance image clarity and improve information extraction …


Statistics For Social Scientists Who Are A Little Afraid Of Them, Kristie L. Campana Jan 2026

Statistics For Social Scientists Who Are A Little Afraid Of Them, Kristie L. Campana

MSU Authors Collection

This is a free textbook aimed at helping advanced undergraduate/beginner graduate students navigate statistics in the social sciences. All resources for this book are released under a creative commons license CC BY-SA 4.0. which means you are able to share, copy, and distribute the material in any medium or format, and that you can adapt and transform upon this content for any purpose. However, this can occur only under the following terms:

You must give appropriate attributions to the text, provide a link to the license, and indicate if any alterations to the text have been made. This can be …


Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar Jan 2026

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …


Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima Jan 2026

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …


Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau Jan 2026

Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau

Theses and Dissertations

The Densest Subgraph Discovery (DSD) problem is a prevalent problem in the field of graph mining, aiming to find the cohesive subgraph. Given a graph �� = (��,��) and an integer �� ≥ 2, the goal is to find a vertex sub- set �� ⊆ �� whose induced subgraph �� (��) maximizes the ��-clique density, defined as the number of ��-cliques per vertex. Larger val- ues of �� capture higher-order connectivity patterns beyond edges, enabling the discovery of more cohesive structures. There have been many solutions to this problem. However, one avenue that other graph mining problems have gone down …


Antibacterial Peptides From Soybean (Glycine Max (L.) Merr.) With In Silico Study Against Escherichia Coli Bacteria, Dian Riana Ningsih, Ely Setiawan, Purwati Purwati, Zusfahair Zusfahair, Anita Hindayanti Rukmana Jan 2026

Antibacterial Peptides From Soybean (Glycine Max (L.) Merr.) With In Silico Study Against Escherichia Coli Bacteria, Dian Riana Ningsih, Ely Setiawan, Purwati Purwati, Zusfahair Zusfahair, Anita Hindayanti Rukmana

Karbala International Journal of Modern Science

Bioactive peptides are produced from soy milk protein hydrolysis using trypsin. The research began with the preparation and separation of soy milk protein, followed by fractionation using ammonium sulphate, protein hydrolysis, and SDS-PAGE analysis of protein hydrolysates. Fractions exhibiting the highest degree of hydrolysis were further fractionated by SPE and tested to determine the antibacterial activity Staphylococcus aureus and Escherichia coli. The peptide sequence of the active peptide as an antibacterial was identified, employing LC-HRMS. The mode of action between active peptides and bacterial membran was analysed using molecular dynamics (MD) simulation. The findings displayed that F15 contained the highest …


Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams Jan 2026

Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams

Natural Resources Research Articles

Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …


Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer Jan 2026

Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer

LSU Doctoral Dissertations

Emerging infectious diseases pose imminent risk to the marine realm and coral reefs in particular. Since its emergence in 2014, stony coral tissue loss disease (SCTLD) has dramatically reduced living coral cover in Florida and charted a similar course in the Caribbean. SCTLD is by far the most severe coral disease in history and has driven highly susceptible species to local extinction, yet the mechanisms driving the regional epizootic are not well understood. Here, we developed reef-scale parameterizations of disease spread using model sites in the lower Florida Keys, developed extensive metacommunity habitat maps for the US Caribbean, and then …


Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser Jan 2026

Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser

Engineering Faculty Articles and Research

The COVID-19 pandemic has highlighted the importance of rapid clinical decision-making to facilitate the efficient usage of healthcare resources. Over the past decade, machine learning (ML) has caused a tectonic shift in healthcare, empowering data-driven prediction and decision-making. Recent research demonstrates how ML was used to respond to the COVID-19 pandemic. This paper puts forth new computer-aided COVID-19 disease screening techniques using six classes of ML algorithms (including penalized logistic regression, random forest, artificial neural networks, and support vector machines) and evaluates their performance when applied to a real-world clinical dataset containing patients’ demographic information and vital indices (such as …


Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck Jan 2026

Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck

Chemistry: Faculty Publications

Combinatorial methods for preparing polymeric biomaterials enable the rapid identification of materials useful for many applications in science, medicine, and engineering. In the work described here, we demonstrate that side-chain reactive polymers can be used as templates for the rapid preparation of a small library of diversely functionalized protein–polymer conjugates. The activated ester polymer poly(pentafluorophenyl acrylate) (PPFPA) was modified postpolymerization with substoichiometric equivalents of three hydrophilic primary amines to yield a library of amphiphilic, side-chain reactive copolymers. These copolymers were then conjugated to two receptor-targeting proteins, holotransferrin (hTF) and an engineered fibronectin-based protein (Fn3), through amine-activated ester coupling. We investigated …


Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi Jan 2026

Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi

Karbala International Journal of Modern Science

Background: While male infertility has become a significant global health concern, conventional analysis of semen has not made progress in the detection of contraindicated molecular biomarkers, such as sperm-associated antigen 6 (SPAG6), which is a protein involved in axonemal structure and flagellar motility.

Hypothesis: Expression of SPAG6 correlates with sperm motility and structural integrity. This means that its dysregulation may serve as a molecular indicator of impaired sperm performance.

Methods: A comprehensive review of recent studies was conducted with a focus on SPAG6’s molecular characteristics, expression patterns in normal versus abnormal spermatozoa, and the role it plays in motility-related …


Optimized Co2 Gas Sensing With Sns:Sm2o3/N-Si Nanocomposites Fabricated Via Spray Pyrolysis, Wasan A. Khalaf, Mays A. Hammadi, Mohammed J. Alsultani, Yahya R. Hathal, Mohammed O. Salman Jan 2026

Optimized Co2 Gas Sensing With Sns:Sm2o3/N-Si Nanocomposites Fabricated Via Spray Pyrolysis, Wasan A. Khalaf, Mays A. Hammadi, Mohammed J. Alsultani, Yahya R. Hathal, Mohammed O. Salman

Karbala International Journal of Modern Science

In this work, tin sulfide:samarium oxide (SnS:Sm2O3) composite films were deposited using a spray pyrolysis technique for room-temperature CO2 gas sensing. X-ray diffraction (XRD) confirmed a polycrystalline SnS nature of orthorhombic-phase crystallinity at 10 at.% Sm ions, while 20 at.% Sm induced Sm2O3 as a separate phase. Field emission-scanning electron microscopy (FE-SEM) induced uniform grains and increased the surface roughness, enhancing gas adsorption. UV-visible absorbance revealed band-gap narrowing. Fourier transform infrared spectroscopy (FTIR) analysis revealed vibrational band shifts, confirming the structural modifications. Gas-sensing measurements demonstrated 5.72%, 19.65%, and 9.65% for pure SnS, …


Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro Jan 2026

Qualitative And Numerical Observations Into The Career Trajectories Of Early Career Academics: A Mathematical Model Approach, Oluwatayo M. Ogunmiloro

Tanzania Journal of Science

This study develops and analyzes a mathematical model that describes the interplay among different researcher groups within academia by focusing on how variables such as mentorship, access to funding, and academic peer influence affect the career trajectories of early-career, experienced, redundant, and successful researchers. Using stability theory and relevant theorems of differential equations, this study ensures the existence, uniqueness, positivity, and boundedness of the model's solutions. Additionally, the model’s equilibrium states, are analyzed to determine the local asymptotic stability. Numerical simulations using the Runge-Kutta fourth-order (RK4) method, implemented in Python, are performed to illustrate issues related to career growth within …


Geophysical Analysis Of Volcanic Soils Influencing Microbial Habitat Dynamics On Taal Volcano Island, Ray Albert E. La Rosa, Iluminada A. Ronio, Shaun Michael C. Basco, Martin Gabriel Z. Dela Cruz Jan 2026

Geophysical Analysis Of Volcanic Soils Influencing Microbial Habitat Dynamics On Taal Volcano Island, Ray Albert E. La Rosa, Iluminada A. Ronio, Shaun Michael C. Basco, Martin Gabriel Z. Dela Cruz

The Lasallian Journal of Health

Taal Volcano Island in Batangas, Philippines, hosts an active post-caldera complex with a large hydrothermal system producing extreme soil environments. This study analyzed the geophysical and geochemical characteristics of shoreline soils to determine their potential as microbial habitats. Soil samples were collected at 14°02′04″N, 121°00′09″E, one meter below the surface of near newly formed vents. Physical parameters, including water content, bulk density, sedimentation, texture, and porosity, were measured alongside pH and temperature data. Results revealed sandy soil texture with 25% moisture, moderate compaction (1.66 g cm⁻³), high surface temperature (50 °C on-site; 72.7 °C PHIVOLCS data), and extreme acidity (pH …


High Spatiotemporal Resolution Monitoring Of Crop Water Stress Across The Contiguous United States Using Harmonized Landsat And Sentinel-2 Data, Na Chen, Yanlei Feng, Na Wang, Jevan Yu, Mohammad Reza Alizadeh, Yifeng Cui, Ning Ye, Wenzhe Jiao, Joshua B. Fisher, César Terrer Jan 2026

High Spatiotemporal Resolution Monitoring Of Crop Water Stress Across The Contiguous United States Using Harmonized Landsat And Sentinel-2 Data, Na Chen, Yanlei Feng, Na Wang, Jevan Yu, Mohammad Reza Alizadeh, Yifeng Cui, Ning Ye, Wenzhe Jiao, Joshua B. Fisher, César Terrer

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Accurate and timely monitoring of crop water stress is essential for efficient agricultural water management, ultimately maintaining and improving crop productivity. While Landsat has been used for this purpose, its temporal resolution hampers timely detection of crop water stress. The recently released Harmonized Landsat and Sentinel-2 Version 2.0 dataset, which enables a higher-frequency time series of satellite observations (2–3 days, 30 m), offers a promising solution to this challenge. However, its potential for crop stress monitoring remained unexplored. In this study, we utilized 923 HLS satellite tiles to assess crop water stress across the contiguous United States (CONUS). Crop water …


A Phase 1, First-In-Human, Dose Escalation Study Of Jnj-80038114, A Psmaxcd3 Bispecific Antibody, In Participants With Metastatic Castration-Resistant Prostate Cancer, Andrew Hudson, Anuradha Jayaram, Benjamin Garmezy, Nicholas Zorko, Kevin Zarrabi, Ligi Mathews, Brent Rupnow, Mengjie Li, Debopriya Ghosh, Karen Urtishak, Peter Francis, Sherry Wang, Edward Attiyeh, Johann De Bono Jan 2026

A Phase 1, First-In-Human, Dose Escalation Study Of Jnj-80038114, A Psmaxcd3 Bispecific Antibody, In Participants With Metastatic Castration-Resistant Prostate Cancer, Andrew Hudson, Anuradha Jayaram, Benjamin Garmezy, Nicholas Zorko, Kevin Zarrabi, Ligi Mathews, Brent Rupnow, Mengjie Li, Debopriya Ghosh, Karen Urtishak, Peter Francis, Sherry Wang, Edward Attiyeh, Johann De Bono

Department of Medical Oncology Faculty Papers

PURPOSE: Prostate-specific membrane antigen (PSMA) has been identified as a therapeutic target for metastatic castration-resistant prostate cancer (mCRPC). The recent success of radioligands targeting PSMA spurred development of new PSMA-targeting agents including immunotherapy. JNJ-80038114 is a bispecific antibody that binds PSMA on tumor cells and CD3 on T cells to induce anti-tumor activity.

METHODS: This was a phase 1, open-label, multicenter study of JNJ-80038114 in participants with mCRPC and ≥ 1 prior systemic therapy. JNJ-80038114 was administered subcutaneously every 3 weeks (Q3W), starting at 0.1 mg. The primary endpoint was safety. Secondary endpoints included pharmacokinetics (PK), immunogenicity, and prostate-specific antigen …


A Probabilistic Modeling Analysis Of The Longitudinal Immune Response To Infection And Vaccination Across Demographic Groups And Pulmonary Symptoms, James O'Hanlon, Kaitlyn Sullivan, Lyndsey M. Muehling, Glenda Canderan, Jie Sun, Judith A. Woodfolk, Jeffrey M. Wilson, Rayanne A. Luke Jan 2026

A Probabilistic Modeling Analysis Of The Longitudinal Immune Response To Infection And Vaccination Across Demographic Groups And Pulmonary Symptoms, James O'Hanlon, Kaitlyn Sullivan, Lyndsey M. Muehling, Glenda Canderan, Jie Sun, Judith A. Woodfolk, Jeffrey M. Wilson, Rayanne A. Luke

Spora: A Journal of Biomathematics

Antibody and cytokine kinetics describe the dynamic response to immune events such as infection and vaccination. These dynamics are not fully understood, and mathematical characterization may help explain variability across demographic groups and pulmonary symptoms post-acute infection. We fit time-dependent probability models to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) data to obtain distributions of longitudinal antibody response and cytokine values. To assess differences between groups, an overlap metric is applied to the modeled response curves. Our antibody models suggest significant differences between male and female populations and demonstrate deficient antibody responses of less-healthy groups such as smokers. Our cytokine …


Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata Jan 2026

Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata

Spora: A Journal of Biomathematics

This study employed an age-structured Susceptible-Infected-Recovered-Vaccinated-Deceased (SIRVD) model to design optimal COVID‑19 intervention strategies by integrating epidemiological dynamics with economic costs. Using empirical data from South Korea, we estimated transmission parameters and analyzed quarantine-based non-pharmaceutical interventions (NPIs) alongside targeted vaccination scenarios. Our results indicated that a stronger form of mild NPI (upper range of Level I), when combined with targeted vaccination that prioritized seniors, achieved substantial reductions in infection peaks and overall economic burden. These findings underscore the effectiveness of age-specific strategies in epidemic management and offer critical insights for policymakers seeking balanced, resource-efficient approaches.


Inhomogeneous Branching Random Walks: Incorporating Genealogy And Density Effects, Lauren Ajax, Beatrice Durham, Pratima Hebbar, Cade Johnston, Jiayi Zhang Jan 2026

Inhomogeneous Branching Random Walks: Incorporating Genealogy And Density Effects, Lauren Ajax, Beatrice Durham, Pratima Hebbar, Cade Johnston, Jiayi Zhang

Spora: A Journal of Biomathematics

We introduce a novel framework using inhomogeneous branching random walks (BRWs) to model biological processes, specifically by introducing genealogy-dependence in branching rates and displacement distributions to model bacterial colony growth. Current stochastic models often either assume independent and identical behavior of individual agents or incorporate only spatiotemporal inhomogeneity, ignoring the effect of genealogy-based inhomogeneity on the long-time behavior of these processes. Such asymptotics are of independent mathematical interest and are crucial in understanding the emergence of patterns. We propose several inhomogeneous BRW models in 2D space where displacement distributions and branching rates vary with time, space, and genealogy. A combined …


The Sunday Math Circle, Nathan Pflueger Jan 2026

The Sunday Math Circle, Nathan Pflueger

Journal of Math Circles

Bob and Ellen Kaplan envisioned and organized a style of math circle centered on the idea that children of all ages can work like mathematicians do: creatively, collaboratively, and ecstatically. This article surveys four sample topics covered during a Sunday morning math circle in the Boston area, based on Bob and Ellen's invaluable guidance. I also offer some reflections on what I learned from Bob and Ellen, and how it is reflected in these math circles.


Structural Characterization Of Peptide Nanoaggregates At Varying Concentrations And Their Impact On Cellular Responses, Malika Rozmetova Jan 2026

Structural Characterization Of Peptide Nanoaggregates At Varying Concentrations And Their Impact On Cellular Responses, Malika Rozmetova

Theses and Dissertations

Peptide nano-assemblies can regulate cellular pathways in a structure-dependent manner. Here, we show that the enzyme-responsive peptide NapFFK(NBD)Yp forms distinct nanoscale assemblies at different concentrations, triggering differential ER stress and extracellular vesicle release in MDA-MB231 cells. These results highlight the importance of supramolecular organization in peptide–cell interactions.


Flux Crystal Growth Of Potassium Lanthanide Double Vanadates With Lanthanide-Dependent Coordination Number Variance, Hunter B. Tisdale, Hans Conrad Zur Loye Jan 2026

Flux Crystal Growth Of Potassium Lanthanide Double Vanadates With Lanthanide-Dependent Coordination Number Variance, Hunter B. Tisdale, Hans Conrad Zur Loye

Faculty Publications

A series of potassium rare earth double vanadates is presented. Single crystals of double vanadates with stoichiometry K3Ln(VO4)2 (Ln = La, Pr, Nd, and Sm) and crystallizing in the glaserite structure type were synthesized via a molten alkali chloride/fluoride flux reaction. Different structures were observed depending on the constituent rare earth: K3La(VO4)2 crystallizes in an as-of-yet unreported modification of the typical glaserite structure in the space group P21/c, likely due to its larger ionic size that results in an increase in the lanthanide coordination number …


Assessment Of Heavy Metal Contamination In Surface Water Near Tailings Dam, Gera Techane Mengistu, Tesema Kebede, Enatfenta Melaku, Engdasew Temere Jan 2026

Assessment Of Heavy Metal Contamination In Surface Water Near Tailings Dam, Gera Techane Mengistu, Tesema Kebede, Enatfenta Melaku, Engdasew Temere

Journal of Sustainable Mining

Elevated levels of heavy metals in surface water can lead to the degradation of water quality, especially in mining areas where tailing dams are sources of heavy metal pollution. This study focuses on evaluating the concentrations of heavy metals in surface water near the Legadembi tailings dams. The mean concentrations (in µg/L) of various heavy metals including: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl), uranium (U), vanadium (V), tungsten (W), zinc (Zn), and zirconium (Zr) were determined: 79.7, 0.15, 162.3, 0.66, 18.1, 0.01, …


Continuous Sorption Of Ionic Dyes Onto Nanoporous Faujasite Zeolite And The Regeneration Of The Adsorbent, Frederick O. Oshomogho, Miracle Aisosa Omorogieva Jan 2026

Continuous Sorption Of Ionic Dyes Onto Nanoporous Faujasite Zeolite And The Regeneration Of The Adsorbent, Frederick O. Oshomogho, Miracle Aisosa Omorogieva

BAU Journal - Science and Technology

This study evaluates the efficiency of synthesized faujasite zeolite in the continuous removal of methylene blue from water and tests the reusability of the regenerated adsorbent. Faujasite Zeolite was synthesized from locally available aluminosilicate clay in Edo State using standard methods documented in the literature. XRF analysis affirmed the elemental composition, showing high levels of silica and alumina, which increased its adsorption capacity. SEM images depicted a crystal-clear structure with an octahedral shape and visible micro-pores on the surface. TGA showed effective thermal stability below 300 ºC, with a 10% weight loss between 28.59 ºC and 300 ºC. BET analysis …


Crystal Structure Of Methanococcus Jannaschii Dihydroorotase With Substrate Bound, Jacqueline Vitali, Jay C. Nix, Haley E. Newman, Michael J. Colaneri Jan 2026

Crystal Structure Of Methanococcus Jannaschii Dihydroorotase With Substrate Bound, Jacqueline Vitali, Jay C. Nix, Haley E. Newman, Michael J. Colaneri

Physics Faculty Publications

Here, we report the X-ray structural analysis of dihydroorotase from Methanococcus jannaschii co-crystallized with dihydroorotate at pH 6.5. The crystals are isomorphous with the crystals of the apoenzyme, with space group P3221 and unit-cell dimensions a = b = 111.4, c = 101.2 Å. The structure was refined to R = 0.169 and Rfree = 0.186 at a resolution of 1.87 Å at room temperature. During crystallization the degradative reaction took place, and the electron density in the active site corresponds to the substrate carbamoyl aspartate. Carbamoyl aspartate interacts with the protein in the active site …


A. Vs. I In Ai: Is There A Threshold To "Engineered" Intelligence?, Joshit Mohanty Jan 2026

A. Vs. I In Ai: Is There A Threshold To "Engineered" Intelligence?, Joshit Mohanty

Engineering Management & Systems Engineering Faculty Publications

Despite artificial intelligence reshaping the world, its development generates uncertainties regarding future capabilities. AI simultaneously exists as an artifact of engineering design and as autonomous intelligence, creating an observer-participant feedback loop. This paper proposes that embodied AI faces a bandwidth-limited intelligence threshold T_h that it arises from B = min(C_sens,C_Act). However, Shannon capacity measures bits while intelligence operates on concepts, necessitating a dual-channel model separating physical bandwidth B_io from representational capacity B_rep. Intelligence emerges as multi-dimensional rather than scalar, with components exhibiting different bandwidth dependencies. Surpassing T_h requires either new sensing methods expanding B, enhanced representational frameworks, or reconceptualization within …


Zero-Shot Segmentation Of Estuary Mudflats Using The Segment Anything Model, Jaren Unzen Jan 2026

Zero-Shot Segmentation Of Estuary Mudflats Using The Segment Anything Model, Jaren Unzen

Honors Theses and Capstones

Estuary mudflats are ecologically sensitive environments that require consistent monitoring. Traditional satellite-based classification workflows are often constrained by the high cost and labor-intensive nature of manual data annotation. This study evaluates the utility of Segment Anything Model 3 (SAM 3), a foundational computer vision model, to automate mudflat segmentation without domain-specific fine-tuning. By leveraging the model’s text-prompting capabilities alongside specialized pre- and post-processing techniques, we generated segmentation masks in a zero-shot framework. Our approach achieved an F1- score of 0.51, demonstrating the inherent challenges of spectrally complex coastal features. Despite this, the results highlight a promising pathway for adapting large-scale …


Leveraging Machine Learning Techniques To Identify Catastrophic Outliers In Photometric Redshift Estimates, Jason Yoo Jan 2026

Leveraging Machine Learning Techniques To Identify Catastrophic Outliers In Photometric Redshift Estimates, Jason Yoo

Honors Theses

Leveraging the unprecedented data volumes from modern astronomical surveys, this work addresses the critical challenge of identifying catastrophic outliers (COs) in photometric redshift (photo-z) estimates. Reliable redshift estimation is essential for precision cosmology, yet COs (galaxies with severely erroneous photo-z) can introduce significant systematic bias. We develop and evaluate two machine learning approaches for robust CO identification: a multilayer perceptron (MLP) utilizing photo-z point estimates and probability distributions, and a convolutional neural network (CNN) leveraging raw 5-band photometric images. Using datasets emulating LSST conditions, we demonstrate that the MLP model achieves high accuracy and stability across redshift bins, correctly identifying …