Digital Commons Network^™

Increased Birth Weight Is Associated With Altered Gene Expression In Neonatal Foreskin, Leryn J. Reynolds, Rebecca I. Pollack, Richard J. Charnigo, Cetewayo S. Rashid, Arnold J. Stromberg, Shu Shen, John O'Brien, Kevin J. Pearson

Pharmacology and Nutritional Sciences Faculty Publications

Elevated birth weight is linked to glucose intolerance and obesity health-related complications later in life. No studies have examined if infant birth weight is associated with gene expression markers of obesity and inflammation in a tissue that comes directly from the infant following birth. We evaluated the association between birth weight and gene expression on fetal programming of obesity. Foreskin samples were collected following circumcision, and gene expression analyzed comparing the 15% greatest birth weight infants (n = 7) v. the remainder of the cohort (n = 40). Multivariate linear regression models were fit to relate expression levels on differentially …

A Novel Diffuse Fraction-Based Two-Leaf Light Use Efficiency Model: An Application Quantifying Photosynthetic Seasonality Across 20 Ameriflux Flux Tower Sites, Hao Yan, Shao-Qiang Wang, Kai-Liang Yu, Bin Wang, Qin Yu, Gil Bohrer, Dave Billesbach, Rosvel Bracho, Abdullah F. Rahman, Herman H. Shugart

School of Earth, Environmental, & Marine Sciences Faculty Publications

Diffuse radiation can increase canopy light use efficiency (LUE). This creates the need to differentiate the effects of direct and diffuse radiation when simulating terrestrial gross primary production (GPP). Here, we present a novel GPP model, the diffuse-fraction-based two-leaf model (DTEC), which includes the leaf response to direct and diffuse radiation, and treats maximum LUE for shaded leaves (ɛmsh defined as a power function of the diffuse fraction (Df)) and sunlit leaves (ɛmsu defined as a constant) separately. An Amazonian rainforest site (KM67) was used to calibrate the model by simulating the linear relationship …

Cross-Modal Recipe Retrieval With Rich Food Attributes, Jingjing Chen, Chong-Wah Ngo, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Food is rich of visible (e.g., colour, shape) and procedural (e.g., cutting, cooking) attributes. Proper leveraging of these attributes, particularly the interplay among ingredients, cutting and cooking methods, for health-related applications has not been previously explored. This paper investigates cross-modal retrieval of recipes, specifically to retrieve a text-based recipe given a food picture as query. As similar ingredient composition can end up with wildly different dishes depending on the cooking and cutting procedures, the difficulty of retrieval originates from fine-grained recognition of rich attributes from pictures. With a multi-task deep learning model, this paper provides insights on the feasibility of …

Role Of Viruses Within Metaorganisms: Ciona Intestinalis As A Model System, Brittany A. Leigh

USF Tampa Graduate Theses and Dissertations

Marine animals live and thrive in a literal sea of microorganisms, yet are often able to maintain specific associations that are largely dictated by the environment, host immunity and microbial interactions. Animal-associated microbiomes include bacteria and viruses that vastly outnumber host cells, especially in the gut environment, and are considered to be integral parts of healthy, functioning animals that act as a metaorganism. However, the processes underlying the initial establishment of these microbial communities are not very well understood. This dissertation focuses on the establishment of a well-known developmental animal model, Ciona intestinalis (sea squirt), to study the establishment and …

Food Habits And Anthropogenic Supplementation In Coyote Diets Along An Urban-Rural Gradient, Erica Santana, Jim Armstrong

Human–Wildlife Interactions

Coyotes are recent colonists of the Southeast and have broadened their niche to include exploitation of urban areas. The aim of this study was to examine diet of coyotes inhabiting areas of differential development by humans and assess prevalence of anthropogenic feeding, to detect a possible shift in dietary trends. In urban, exurban, and rural areas of east-central Alabama, 159 fecal samples were collected and examined to reconstruct the diet. Consumption of anthropogenic food did not vary significantly along an urban-rural gradient and foods consumed were similar among habitats. While results of this study can provide insight to guide decisions …

Dietary Inflammatory Index And Colorectal Cancer Risk – A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael David Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso

Faculty Publications

Diet and chronic inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet, measured through the Dietary Inflammatory Index (DII®), and CRC has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from nine studies were eligible, of which five were case-control and four were cohort studies. Results from meta-analysis showed a positive association between increasing DII scores, indicating a pro-inflammatory diet, and CRC. Individuals in the highest versus …

Calories And Land

Activities

In this exercise, you will investigate how your own diet affects the agricultural demands of a country. You will do this by monitoring your food and drink intake for 3 days, and recording it on the attached activity sheet. At the end of this time, you will add up the number of calories consumed and find the average amount for each day. Most of your packaged food should come with some type of caloric guidelines. If it does not, a fairly complete listing of the calories of various foodstuffs can be found here. As best you can, you need to …

Using The Nasa Worldwind Agrosphere Web App As A Climate Change Modeling Tool In The Classroom, Nicholas Rubel, Patrick Hogan, Stacey Chen, Endia Irazarry, Atreya Iyer, John Nguyen, Mingda Tang

STAR Program Research Presentations

Climate change is a clear and imminent threat to the world today. While there are Next Generation Science Standards (NGSS) for teaching climate change in the classroom, students may have a difficult time understanding the seriousness of the issue. One of the standards in the NGSS is for students to develop their own explanation of climate change and its impact. That’s where AgroSphere comes in. AgroSphere is a web-based app that utilizes NASA open-source software WorldWind. WorldWind allows developers to create their own Java, Android, or web-based apps that can display data on the globe. AgroSphere displays historical weather (climate) …

Physical Water Scarcity Metrics For Monitoring Progress Towards Sdg Target 6.4: An Evaluation Of Indicator 6.4.2 “Level Of Water Stress”, D. Vanhama, A. Y. Hoekstra, Y. Wada, F. Bouraoui, A. De Roo, Mesfin Mekonnen, W. J. Van De Bund, O. Batelaan, P. Pavelic, W. G.M. Bastiaanssen, M. Kummu, J. Rockström, J. Liu, B. Bisselink, P. Ronco, A. Pistocchi, G. Bidoglio

Daugherty Water for Food Global Institute: Faculty Publications

Target 6.4 of the recently adopted Sustainable Development Goals (SDGs) dealswith the reduction ofwater scarcity. To monitor progress towards this target, two indicators are used: Indicator 6.4.1 measuring water use efficiency and 6.4.2 measuring the level of water stress (WS). This paper aims to identify whether the currently proposed indicator 6.4.2 considers the different elements that need to be accounted for in a WS indicator.WS indicators compare water use with water availability.We identify seven essential elements: 1) both gross and net water abstraction (or withdrawal) provide important information to understand WS; 2) WS indicators need to incorporate environmental flow requirements …

Dietary Guidelines And Its Implications For Coconut Oil, Fabian M. Dayrit

Chemistry Faculty Publications

The dietary advice that is generally followed nationally and internationally closely follows the Dietary Guidelines for Americans which was first published in 1980 and which has been through eight editions. All of the editions of the Dietary Guidelines recommend a diet that is low in fat, and most editions recommend the replacement of saturated fat with polyunsaturated fat. This recommendation is based on the saturated fat-cholesterol-heart disease hypothesis that was first proposed by Ancel Keys in the 1950s. Coconut oil was labeled as unhealthy because of its high saturated fat composition. However, this label is unwarranted. Re-analysis of the work …

Impact Of Habitat Degradation On Species Diversity And Nest Abundance Of Five African Stingless Bee Species In A Tropical Rainforest Of Kenya, Nkoba Kiatoko, Suresh Kumar Raina, Frank Van Langevelde

All Peer-Reviewed Publications

Natural habitat degradation often involves the reduction or disappearance of bee species. In Africa, stingless bees are hunted for honey, which is used as food, for medicinal purposes, and for traditional rituals. Severe habitat degradation due to human settlement is hypothesized to have a negative impact on the species diversity of the African stingless bee species. In this paper, we assess the impact of habitat degradation on the diversity of five stingless bee species across different habitats in the tropical rainforest of Kenya (indigenous forest, mixed indigenous forest) and its neighbouring landscape (grassland, village) in western Kenya. The species fauna, …

Level Of Exposure Of Childhood Tuberculosis With Adult Pulmonary Tuberculosis Household Contacts, Al Asyary, Tris Eryando, Purwantyastuti Purwantyastuti, Purnawan Junadi, Carol Clark, Edwin Van Teijlingen

Kesmas

Tuberkulosis paru (TB) pada anak kian menjadi masalah kesehatan global yang masih terlupakan seiring dengan peningkatan proporsi TB di Indonesia. Penularan penyakit ini di populasi umum seringkali berdampak pada anak, terlebih ketika kontak TB terjadi di rumah tangga. Penelitian ini bertujuan untuk memperoleh faktor protektif sehingga anak tetap sehat meskipun memiliki kontak dengan penderita TB dewasa serumah. Penelitian ini dilakukan dengan pendekatan kasus kontrol pada 132 responden anak yang berasal dari delapan rumah sakit rujukan dan beberapa puskesmas di Provinsi Daerah Istimewa Yogyakarta. Penelitian dilakukan dalam periode Januari hingga Desember 2014 yang hasilnya dianalisis dengan uji bivariat (kai kuadrat) dan …

Influence Of Quality Of Work Life Towards Psychological Well-Being And Turnover Intention Of Nurses And Midwives In Hospital, Indra Wahju Hardjanti, Aryo Dewanto, Noermijati Noermijati

Kesmas

Selama ini perawat telah dilatih untuk memberikan perawatan pasien dan meningkatkan kualitas hidup pasien, namun kualitas kehidupan kerja dan psychological well-being mereka sendiri terabaikan. Rendahnya kualitas kehidupan kerja perawat di rumah sakit menyebabkan tingginya keinginan pindah kerja perawat. Tingginya angka keinginan pindah kerja perawat dan bidan di Rumah Sakit X Malang merupakan masalah yang memerlukan perhatian dari manajemen rumah sakit agar tidak menjadi menyebabkan rendahnya mutu pelayanan kesehatan di rumah sakit. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas kehidupan kerja, psychological well-being, dan keinginan pindah kerja perawat dan bidan di rumah sakit. Penelitian ini menggunakan desain penelitian kuantitatif korelasional …

Risk Differences Between Elderly Men And Women Toward Doctor-Diagnosed Diabetes Mellitus In Urban Areas In Indonesia: 2013 National Basic Health Research Data, Meiwita Budiharsana

Kesmas

Diabetes melitus (DM) adalah salah satu penyakit tidak menular yang paling umum di Indonesia. DM disebabkan berbagai faktor risiko. Peningkatan prevalensi DM salah satunya disebabkan oleh perubahan gaya hidup di perkotaan. Penelitian ini bertujuan untuk menguji perbedaan prevalensi DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15 tahun keatas yang tinggal di daerah perkotaan di Indonesia. Analisis menggunakan data sekunder Riset Kesehatan Dasar (Riskesdas) 2013 dengan desain studi potong lintang. Total sampel sebanyak 333.731 responden. Metode analisis menggunakan regresi logistik ganda. Hasil menunjukkan bahwa DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15-39 tahun di perkotaan tidak berbeda. …

Bancroftian Filariasis Transmission Parameters After The Fifth Year Of Filiariasis Mass Drug Administration In Pekalongan City, Tutik Ida Rosanti, Sugeng Juwono Mardihusodo, Wayan Artama

Kesmas

Penelitian ini bertujuan untuk mengukur parameter parasitologi (microfilaria rate, kepadatan mikrofilaria), parameter imunologi (antigen prevalence) dan parameter entomologi (infection rate dan infective rate) pada tahun kelima pelaksanaan mass drug administration di Kelurahan Pabean Kota Pekalongan. Penelitian ini merupakan penelitian observasional dengan pendekatan potong lintang yang dilaksanakan pada bulan Juli sampai dengan Agustus 2015 di Kelurahan Pabean Kota Pekalongan. Microfilaria rate dan kepadatan mikrofilaria ditentukan dengan pemeriksaan darah jari pada 313 responden. Antigen prevalence ditentukan dengan mengukur antigen beredar menggunakan metode immunochromatographic test (ICT) Wuchereria bancrofti. Incective rate dan infection rate diukur dengan cara menemukan larva cacing filaria pada nyamuk hasil …

Influence Of Scaling Up Nutrition Education Towards Knowledge And Attitude Of Students At Santa Elisabeth Medan School Of Health Sciences, Rani Gartika Holivia Silalahi, Yesschi Anggraeni Tambunan

Kesmas

Tingginya angka pernikahan pada usia remaja yang disertai dengan rendahnya pengetahuan tentang pola asuh merupakan salah satu pemicu terjadinya masalah gizi. Remaja merupakan orang tua masa depan. Tujuan penelitian ini untuk mengetahui pengaruh pendidikan 1.000 hari pertama kehidupan terhadap pengetahuan dan sikap mahasiswi Sekolah Tinggi Ilmu Kesehatan Santa Elisabeth Medan tahun 2016. Penelitian ini menggunakan kuasi eksperimental dengan desain one group pre- dan post test. Metode pengambilan sampel dengan metode purposive sampling sebanyak 115 mahasiswi tingkat III program studi Diploma III Kebidanan. Pendidikan dilakukan di kelas sebanyak 4 kali dalam 2 minggu dengan menggunakan metode mengajar dan diskusi. Penelitian ini …

Provision Of Informed Consent Towards The Level Of Anxiety In Pre-Operative Patients At Mamuju District Public Hospital, Imelda Appulembang

Kesmas

Tindakan pembedahan merupakan salah satu tindakan medis yang dapat mendatangkan stressor sehingga menimbulkan kecemasan pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian informed consent terhadap tingkat kecemasan pada pasien pra-operasi di Rumah Sakit Umum Daerah (RSUD) Mamuju. Populasi pada penelitian ini adalah pasien pra-operasi. Sampel ditentukan dengan menggunakan pendekatan accidental sampling sehingga diperoleh sampel sebanyak 32 orang. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan metode quasi experimental design melalui pendekatan non-equivalent time sample design yang dianalisis dengan menggunakan uji statistik Wilcoxon. Hasil penelitian menunjukkan bahwa terdapat pengaruh pemberian informed consent terhadap tingkat kecemasan pasien. Dapat disimpulkan pemberian informed …

The Profile And Determinant Factors Of Quality Of Life In Patients With Diabetic Neuropathy, Rizaldy Taslim Pinzon, Kadek Sinthia Grahita Adnyana, Marta Lisnawati Zalukhu

Kesmas

Neuropati merupakan salah satu komplikasi tersering pada diabetes melitus (DM). Neuropati dapat memengaruhi kualitas hidup, derajat kesehatan, maupun tingkat ekonomi. Oleh karena itu, penting untuk mengetahui kualitas hidup pasien DM dengan neuropati beserta dampak yang ditimbulkannya terlebih dahulu agar mendapatkan penanganan yang tepat demi meningkatkan kualitas hidup pasien. Penelitian ini bertujuan untuk mengetahui profil kualitas hidup pasien DM dengan neuropati. Penelitian ini merupakan studi observasional menggunakan Short Form 8 (SF-8) Health Survey Standard Indonesia terhadap pasien diabetes melitus dengan neuropati yang diambil secara konsekutif pada bulan Maret hingga Agustus 2016 di Poli Saraf Rumah Sakit Bethesda, Yogyakarta. Terdapat 57 subjek …

Effects Of Contraceptive Use On Productivity Of Women Labor At Pt. Bomar Makassar Industrial Area, Masni Mappajanci, Andi Misnawati, Darmawansyah Darmawansyah

Kesmas

Produktivitas kerja potensial pada kelangsungan hidup perusahaan. Penggunaan kontrasepsi dapat memengaruhi fisiologi setiap perempuan, sehingga dapat memengaruhi aktivitas sehari-hari dan akan berdampak terhadap produktivitas tenaga kerja. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan alat kontrasepsi terhadap produktivitas tenaga kerja perempuan dengan mengontrol usia, pendidikan dan motivasi kerja. Penelitian dengan rancangan potong lintang melibatkan 71 pekerja perempuan PT Bomar Makassar yang telah menikah. Pengumpulan data dilakukan dengan wawancara menggunakan kuesioner pada bulan Mei sampai Juni 2015, kemudian dianalisis secara univariat, bivariat, dan multivariat. Hasil penelitian menunjukkan bahwa terdapat pengaruh penggunaan alat kontrasepsi terhadap produktivitas kerja setelah dikontrol dengan variabel usia (nilai …

Impacts Of A Community Supported Agriculture (Csa) Voucher Program On Food Lifestyle Behaviors: Evidence From An Employer-Sponsored Pilot Program, Jairus J. Rossi, Timothy A. Woods, James E. Allen Iv

Agricultural Economics Faculty Publications

Community supported agriculture (CSA) programs have recently received attention for their potential to influence food lifestyle behaviors and health outcomes. We build on and expand inquiries into the relationship between CSA participation and behavior change by presenting the results from a controlled pilot study of first-time CSA shareholders. We offered 95 first-time shareholders a $200 voucher to participate in a CSA. Prior to and immediately following CSA participation, these shareholders completed a survey on food lifestyle behaviors. Using econometric analyses, we measured shareholder behavior changes against an 82 person control group. All participants were drawn from a pool of individuals …

Identification Of Hydrated And Dehydrated Lipids And Protein Secondary Structures In Seeds Of Cotton (Gossypium Hirsutum) Line, Diwas Kumar Silwal, Nsoki Phambu, Bharat Pokharel, Ahmad Naseer Aziz

Chemistry Faculty Research

Cottonseeds from two parents (TM-1 and 3-79) and their 17 progeny (chromosomal substitution) lines were analyzed for various secondary structures of proteins and moisture content of lipids, separately in hulls and kernels. Fourier transform infrared spectroscopy (FTIR) was used on mature seeds from Upland cotton (G. hirsutum) progeny lines and parents. Based on secondary structures of proteins and hydration levels of lipids, differences were observed among the cottonseeds. The two progeny lines – CS-B12sh and CS-B22sh retained lipid moisture content and protein secondary structures similar to both parents, while CS-B06, CS-B15sh and CS-B16 remained distinct from either parent. On the …

Neurological Impact Of Zinc Excess And Deficiency In Vivo, Ronald Bartzatt

Chemistry Faculty Publications

Zinc is an essential mineral that can cause pathological effects whether in excess or deficiency. Zinc is a component for over 250 enzymes and is required for cell growth, cell division, and cell function. Zinc is found in muscle and bones, with the prostrate, liver, skin, and kidney having detectable levels of zinc. However, zinc present in excess or deficiency can cause significant pathology in patients that include deleterious effects neurologically. Zinc in excess in vivo can cause focal neuronal pathology, while zinc deficiency can bring about mental lethargy, neuropsychiatric disorders, and reduced nerve conduction. Zinc is assimilated within the …

A Longitudinal Study Of Privacy Awareness In The Digital Age And The Influence Of Knowledge, Therese L. Williams

Theses and Dissertations

Privacy, in the modern connected world, has become a much discussed topic in society ranging from privacy concerns to impacts, attitudes, practices and technologies. In today’s environment of vast social media and revelations of government spying, personal privacy is being highlighted as either non-existent or something that can be achieved to different degrees with knowledge or awareness of how our private information is collected and used. This research strives to answer the question "Using Alan Westin's privacy categories, what is the general awareness of privacy issues in social media and smartphone usage and how does it change when knowledge is …

Trade-Offs: The Production Of Sustainability In Households, Kirstin Marie Elizabeth Munro

Dissertations and Theses

Over the past half-century, environmental problems have become increasingly serious and seemingly intractable, and a careless, clueless, or contemptuous consumer is often portrayed as the root cause of this environmental decline. This study takes a different approach to evaluating the demand for resources by households, assessing possible pro-environmental paths forward through a study of highly ecologically-conscious households. By modeling "green" households as producers of sustainability rather than consumers of environmental products, the sustainability work that takes place in households is brought into focus. An investigation of household sustainability production makes possible the evaluation of the trade-offs inherent in these pro-environmental …

The Relationship Of Plasma Trans Fatty Acids With Dietary Inflammatory Index Among Us Adults, Mohsen Mazidi, Hong-Kai Gao, Nitin Shivappa, Michael David Wirth, James R. Hébert, Andre Pascal Kengne

Faculty Publications

Background: It has been suggested that trans fatty acids (TFAs) play an important role in cardiovascular diseases. We investigated the association between plasma TFAs and the dietary inflammatory index (DII) ™ in US adults.

Methods: National Health and Nutrition Examination Survey (NHANES) participants with data on plasma TFAs measured from 1999 to 2010 were included. Energy-adjusted-DII ™ (E-DII ™) expressed per 1000 kcal was calculated from 24-h dietary recalls. All statistical analyses accounted for the survey design and sample weights.

Results: Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age of the population was 47.1 …

Correlation Of Trichome Density And Length And Polyphenol Fluorescence With Susceptibility Of Five Cucurbits To Didymella Bryoniae, Gabriel Rennberger, A. P. Keinath, M. Hess

Publications

The fungal pathogen Didymella bryoniae causes gummy stem blight and black rot on a broad spectrum of cucurbits. However the substantial differences in susceptibility among Cucurbitaceae are not well studied. Susceptibility was characterized with muskmelon (Cucumis melo), watermelon (Citrullus lanatus), cucumber (Cucumis sativus), pumpkin (Cucurbita pepo), and zucchini (C. pepo). Lesion diameters on leaf disks inoculated with agar plugs were measured 7 days after inoculation, and the necrotized areas of leaf disks inoculated with conidial suspensions were measured 48 h after inoculation (hai). For each species, the number of trichomes …

Characterization Of The Relationships Between Soybean Yield, Trifoliolate Leaf Chloride Concentration, And Cultivar Chloride Inclusion/Exclusion Rating, Dillon Cox

Graduate Theses and Dissertations

Chloride toxicity is recognized as yield limiting problem in soybean [Glycine max (L.) Merr.] production. Limited information is available to accurately diagnose and manage Cl toxicity. The only recommendation for Cl toxicity management is to plant an excluder cultivar, however the cultivar Cl sensitivity rating system (excluder, includer, and mixed) does not appear to capture the variability in cultivar Cl tolerance. The objectives of this research were to i) develop critical tissue-Cl concentrations in which yield loss occurs for excluder and includer cultivars and ii) investigate the variability in cultivar Cl ratings. A study was conducted across five site-years using …

A Comparative Analysis Of Feed And Environmental Factors On Broiler Growth In The United States, Alexandra Gulli

Graduate Theses and Dissertations

Broiler production in the United States has become an important industry within the last half century. As the demand for poultry continues to increase and the concern of climate change also increases, it will become an important part of the industry to become more sustainable. This study uses a feed optimization model, a broiler growth model, and a life cycle assessment (LCA) to determine how feed ingredients and the barn environment can affect the broiler’s growth and production emissions. A multi-criteria ration optimization model is used to produce feeds based on carbon footprint and cost. A growth model is used …

First-In-Human Clinical Trial Of Oral Onc201 In Patients With Refractory Solid Tumors, Mark N. Stein, Joseph R. Bertino, Howard L. Kaufman, Tina M. Mayer, Rebecca A. Moss, Ann W. Silk, Nancy Chan, Jyoti Malhotra, Loma Rodriguez, Joseph Aisner, Robert Aiken, Bruce G. Haffty, Robert S. Dipaola, Tracie Saunders, Andrew Zloza, Sherri Damare, Yasmeen Beckett, Bangning Yu, Saltanat Najmi, Christian Gabel, Sioghan Dickerson, Ling Zheng, Wafik S. El-Deiry, Joshua E. Allen, Martin Stogniew, Wolfgang Oster, Janice M. Mehnert

Internal Medicine Faculty Publications

Purpose: ONC201 is a small-molecule selective antagonist of the G protein–coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine its recommended phase II dose (RP2D).

Experimental Design: This open-label study treated 10 patients during dose escalation with histologically confirmed advanced solid tumors. Patients received ONC201 orally once every 3 weeks, defined as one cycle, at doses from 125 to 625 mg using an accelerated titration design. An additional 18 patients were treated at the RP2D in an expansion phase to collect additional safety, …

Bayesian Approach On Short Time-Course Data Of Protein Phosphorylation, Casual Inference For Ordinal Outcome And Causal Analysis Of Dietary And Physical Activity In T2dm Using Nhanes Data., You Wu

Electronic Theses and Dissertations

This dissertation contains three different projects in proteomics and causal inferences. In the first project, I apply a Bayesian hierarchical model to assess the stability of phosphorylated proteins under short-time cold ischemia. This study provides inference on the stability of these phosphorylated proteins, which is valuable when using these proteins as biomarkers for a disease. in the second project, I perform a comparative study of different confounding-adjusted to estimate the treatment effect when the outcome variable is ordinal using observational data. The adjusted U-statistics method is compared with other methods such as ordinal logistic regression, propensity score based stratification and …