Digital Commons Network^™

Comparative Modelling Of A Novel Enzyme: Mus Musculus Leucine Decarboxylase, Ari̇f Sercan Şahutoğlu

Turkish Journal of Chemistry

Leucine decarboxylase (LDC) is a recently proposed enzyme with no official enzyme commission number yet. It is encoded by the Mus musculus gene Gm853 which is expressed at kidneys, generating isopentylamine, an alkylmonoamine that has not been described to be formed by any metazoan enzyme yet. Although the relevance of LDC in mammalian physiology has not been fully determined, isopentylamine is a potential modulator which may have effects on insulin secretion and healthy gut microbiota formation. The LDC is a stable enzyme that specifically decarboxylates L-leucine but does not decarboxylate ornithine or lysine as its paralogues ornithine decarboxylase (ODC; EC: …

An Anthracene Based Fluorescent Probe For The Selective And Sensitive Detection Of Chromium (Iii) Ions In An Aqueous Medium And Its Practical Application, Erman Karakuş

Turkish Journal of Chemistry

An anthracene based fluorescent probe, integrated with thiophene moiety, exhibited selective and sensitive detection of chromium (III) ions over other metal ions. Its synthesis was achieved by simple mixing of two commercially available compounds, 2-aminoanthracene, and 2-thiophenecarboxaldehyde, in onestep without the needed complex purification process. The probe molecule (ANT-Th) offered exceptional features such as "turn-on" fluorescence response, low detection limit (0.4 μM), and fast response time (< 1 min) via C$=$N bond hydrolysis. Also, a simple test paper system was developed for the rapid detection of chromium (III) ions with the naked eye.

Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği

Turkish Journal of Chemistry

Since benzo [$b$] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[$b$]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[$b$]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, $^{1}$H NMR and $^{13}$C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSAR-based models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this theoretical study. …

Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş

Turkish Journal of Chemistry

Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …

Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda

Turkish Journal of Chemistry

The objective of this study is to synthesize ZnO and Mg doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH$_{3}$COO)$_{2}$.2H$_{2}$O) and magnesium acetate tetrahydrate (Mg(CH$_{3}$COO)$_{2}$.4H$_{2}$O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively. Structural and morphological characterizations of Zn$_{1-x}$Mg$_{x}$O nanoparticles were studied by using XRD and SEM-EDX, respectively. Photocatalytic activities of ZnO and selected Mg-doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles were investigated by degradation of methylene blue (MeB). Results …

A Novel Molecular Imprinting Polymer For The Selective Adsorptionof D-Arabinitol From Spiked Urine, Yuni Retnaningtyas, Ganden Supriyanto, Ni Nyoman Tri Puspaningsih, Roedi Irawan, Siswandono Siswodihardjo

Turkish Journal of Chemistry

In this research, molecular imprinting polymers (MIPs) for D-arabinitol were synthesized using a bulk polymerization method through a noncovalent approach. The MIPs were prepared by using D-arabinitol as a template, acrylamide as a functional monomer, ethylene glycol dimethacrylateas cross-linker, benzoyl peroxide as an initiator and dimethyl sulfoxideas a porogen. MIPS was synthesized in several formulas with a different molar ratio of template to functional monomers and cross-linker. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the MIPs produced. A batch rebinding assay was used to test the binding efficiency of each formula. Batch rebinding test …

Phase Separation Behavior Of Whey Protein Isolate Particle Dispersions In The Presence Ofxanthan, Alev Emi̇ne İnce Coşkun

Turkish Journal of Chemistry

In this study, phase separation of colloidal whey protein isolate (WPI) particle dispersions was studied using a rod-like polysaccharide xanthan. Effects of different xanthan concentration, particle volume fraction, and temperature were analyzed by visual observations, turbidity measurements, and particle mobility tracking method. Particle mobility was determined using a diffusing wave spectroscopy (DWS) set up. Xanthan concentration was kept low in order not to increase the viscosity of dispersions, so that the phase separation could be observed easily. Visual observations showed that there was a minimum concentration of xanthan to induce phase separation at a constant particle volume fraction, and xanthan …

Application Of Synthesized Copper Nanoparticles Using Aqueous Extract Ofziziphus Mauritiana L. Leaves As A Colorimetric Sensor For The Detection Of Ag$^{+}$, Roomia Memon, Ayaz Ali Memon, Syed Tufail Hussain Sherazi, Siraj Uddin, Aamna Balouch, Muhammad Raza Shah, Sarfaraz Ahmed Mahesar, Kauser Rajar, Muhammad Hassan Agheem

Turkish Journal of Chemistry

The presented work demonstrates the preparation of copper nanoparticles (CuNPs) via aqueous leaves extract of Ziziphus mauritiana L. (Zm) using hydrazine as a reducing agent. Various parameters such as volume of extract, concentration of hydrazine hydrate, concentration of copper chloride, and pH of the solution were optimized to obtain Ziziphus mauritiana L. leaves extract derived copper nanoparticles (Zm-CuNPs). Brownish red color was initial indication of the formation of Zm-CuNPs while it was confirmed by surface plasmon resonance (SPR) band at wavelength of 584 nm using ultraviolet-visible (UV-vis) spectroscopy. Synthesized Zm-CuNPs were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron …

Effect Of Ph On Lipid Oxidation Of Red Onion Skin Extracts Treated With Washed Tilapia (Oreochromis Niloticus) Muscle Model Systems, Senem Güner, Yavuz Yağiz, Zeynal Topalcengi̇z, Hordur G. Kristinsson, George Baker, Paul Sarnoski, Bruce A. Welt, Amarat Simonne, Maurice M. Marshall

Turkish Journal of Chemistry

The aim of the study was to investigate the effect of pH on the lipid oxidation of red onion skin extracts (ROSEs) treated with washed tilapia muscle model systems (WTMS). Minced and buffered washed samples were prepared at pH 6.3 and 6.8. The WTMS were treated with2 different concentrations of red onion skin prior to storage for 5 days. Lipid oxidation was investigated via peroxide values (PVs), thiobarbituric acid reactive substances (TBARS), and the formation of volatile compounds. Fatty acid profiles of the samples were also identified. The ROSEs were able to significantly suppress the PV (~71%) and TBARS (~42%) …

Chemical Composition, Antimicrobial, And Lipase Enzyme Activity Of Essential Oil And Solvent Extracts From Serapias Orientalis Subsp. Orientalis, İshak Eri̇k, Gözde Kiliç, Eli̇f Öztürk, Şengül Alpay Karaoğlu, Nuretti̇n Yayli

Turkish Journal of Chemistry

The volatile components of essential oil (EO), SPME, and SPME of solvent extracts (n-hexane, methanol, and water) obtained from fresh Serapias orientalis subsp. orientalis(Soo) were analyzed by GC-FID/MS. EO of Soo gave 11 compounds in the percentage of 99.97%; capronaldehyde (37.01%), 2-(E)-hexenal (23.19%), and n-nonanal (19.05%) were found to be major constituents. SPME GC-FID/MS analyses of fresh plant and solvent extracts of Soo revealed 7, 12, 7, and 4 compounds within the range of 99.7% to 99.9%. Limonene (76.5%, 41.7%, and 61.3%) was the major compound in SPMEs of the n-hexane and methanol extracts. α-Methoxy-p-cresol (52.9%) was the main component …

Comparison Of Antioxidant Capacities And Antioxidant Components Of Commercial Bitter Melon (Momordica Charantia L.) Products, Esi̇n Akyüz, Sercan Türkoğlu, Kevser Sözgen Başkan, Esma Tütem, Mustafa Reşat Apak

Turkish Journal of Chemistry

In this study, the total phenolic contents and total antioxidant capacities of some commercial bitter melon products (powder, packaged powder, capsule, paste in olive oil), and of unripe and ripe fruits were determined by spectrophotometric and chromatographic methods. The total antioxidant capacities of unripe and ripe bitter melon samples, determined by using the CUPRAC (cupric reducing antioxidant capacity assay) and ABTS (2,2'-Azinobis-(3-Ethylbenzthiazolin-6-Sulfonic Acid)/HRP (horseradish peroxidase) methods, were 42.5 and 36.3 μmol TRE (Trolox equivalent) g-1, and 8.7 and 7.0 μmol TRE g-1, respectively. The TAC (total antioxidant capacity) order of the studied samples using the same 2 methods were determined …

Processing Impact On Tocopherols And Triglycerides Composition Of Soybean Oil And Its Deodorizer Distillate Evaluated By High-Performance Liquid Chromatography, Zahid Hussain Laghari, Syed Tufail Hussain Sherazi, Hami̇de Fi̇li̇z Ayyildiz, Mustafa Topkafa, Hüseyi̇n Kara, Sarfaraz Ahmed Mahesar, Siraj Uddin

Turkish Journal of Chemistry

In the present study, high-performance liquid chromatography (HPLC) was used for the separation of tocopherols and triglycerides of processed soybean oil and deodorizer distillate (DD). The results of normal and reversed-phase modes of HPLC revealed that concentrations of tocopherols and triglycerides content were decreased during the neutralization, bleaching, and deodorization processes. The loss of individual tocopherols ranged between 55.16% and 63.25%. During processing, triglycerides containing stearic-oleic-linoleic (SOL) moieties and palmitic-palmitic-linoleic (PPL) fragments showed greater reduction up to 38.14% and 37.69%, respectively. Among tocopherols and triglycerides; γ-tocopherol and oleic-oleic-oleic (OOO) were found to be in greater concentrations 5.53% and 19.78%, respectively …

Fabrication And Characterization Of Boric Acid-Crosslinked Ethyl Cellulose And Polyvinyl Alcohol Films As Potential Drug Release Systems For Topical Drug Delivery, Nasrin Aliasgharlou, Farzin Asghari Sana, Saba Khoshbakht, Pezhman Zolfaghari, Hamed Charkhian

Turkish Journal of Chemistry

In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at …

Captive Ring-Necked Pheasant Response To Very High Experimental Doses Of Lead, Travis J. Runia, Alex J. Solem

The Prairie Naturalist

Ingestion of spent lead pellets is a well-documented source of lead exposure in free-ranging birds, although the consequence of lead ingestion varies widely among avian guilds. Ring-necked pheasants (Phasianus colchicus) appear to be less susceptible to lead poisoning than other game birds. Our objectives were to determine survival, liver lead accumulation, and body mass change of 129 captive-raised pheasants in response to being gavage-fed 5, 10, 20, or 40 lead pellets. All pheasants survived the 21-day experiment. Liver-lead levels were positively correlated with the number of lead pellets retained and negatively correlated with beginning body mass. Change in percent body …

A Brief Introduction To The Applications Of Small Organic Molecules As Food Additives, Zhou Zhou

Open Educational Resources

A new chapter in Introductory Organic Chemistry course. Lecture PowerPoint file and laboratory document are also included in this work.

• The goal of this chapter is to cover the basic ground of the food additives from the perspective of organic chemistry. This chapter has three parts.
  • Part one: Introduction of the food additive industry including the history, definition and the purposes of food additives.
  • Part two: The terminology in food additives and in organic chemistry, how to locate trustworthy data sheets for chemicals, and how to interpret the toxicity data.
  • Part three: Different families of organic compounds used as food …

The Impact Of Subsurface Physical Characteristics On The Effectiveness Of Subsurface Drainage In The Northern Great Plains, Mehmet Emin Budak

Electronic Theses and Dissertations

World-wide, salinity and sodicity problems are increasing in coastal, irrigated and dryland agricultural systems. Traditional reclamation techniques for saline sodic soils include improving soil drainage by installing subsurface drainage, leaching with high quality water, and applying a source of calcium. However, due to differences in the soil parent material these traditional approach treatments were ineffective in removing sodium and other salts out of the soil profile of South Dakota. Understanding how the surface and subsurface soil characteristics and management interact to affect the sustainability of these systems is the first step in remediation. Each region and soil have a slightly …

Investigating Links Between Soil Microbial Structure And Function In Three Major Plant Communities Across Temporal Scales Of Arctic Alaska, Kaj Lynoe

Electronic Theses and Dissertations

Arctic microbial systems continue to get attention today as our understanding regarding their structure and function in a changing system is paramount to C feedbacks with warming and changes in precipitation. Plant communities and microbial community processes across the Arctic landscape are central to understanding tundra ecosystem processes because environmental conditions and plant community structure drive microbial cycling of soil organic matter. Here, we want to understand how soil microbial respiration, mineralization, biomass, and community composition are linked to three Alaskan tundra plant communities, namely Shrub, Tussock, and Sedge tundra and the seasonal variability in this system. A total of …

Higher Temperatures Have Contrasting Effects On Different Components Of Forage Quality For Caribou In Northern Alaska, Heidi Becker

Electronic Theses and Dissertations

Rising temperatures in the Arctic may affect vegetation, which in turn can affect herbivores, such as caribou, that rely on these plants for forage. Several plant traits contribute to forage quality, including digestibility, nitrogen content, and antiherbivory secondary compounds, but the effect of temperature on these traits individually and combined is unclear. I conducted a three-component study on the effect of higher temperatures on the forage quality of graminoids, deciduous shrubs, and evergreen dwarf shrubs on the North Slope of Alaska. The components included: 1) short and long-term experimental warming, 2) natural temperature variation between south and north-facing slopes, and …

North Fork: Whitesburg Tributaries Watershed Plan, Letcher County, Ky, Kentucky Water Resources Research Institute

KWRRI Research Reports

Crafts Colly, Sandlick, and Dry Fork are tributaries to the North Fork of the Kentucky River. The three tributaries are located immediately north of the North Fork of the Kentucky and flow southward into the river within or near the City of Whitesburg in Letcher County, Kentucky. Letcher County is found in the Appalachian coalfields of southeastern Kentucky.

To improve water quality in the Kentucky River, water quality impairments in the upper reaches of the watershed must be addressed. In focusing efforts in Crafts Colly, Sandlick, and Dry Fork, three headwater tributaries of the North Fork Kentucky River, pollution loading …

A Review Of Nyoongar Responses To Severe Climate Change And The Threat Of Epidemic Disease—Lessons From Their Past, Francesca Robertson, Jason Barrow

Research outputs 2014 to 2021

Nyoongar people have lived in the South West of Western Australia for at least 50,000 years. During that time, they experienced significant climate change, including wide variations in temperature and rainfall, and hundreds of metres’ difference in sea levels. Nyoongar people have a long memory, and climate change is described in their stories and in the knowledge they hold about how life was lived in earlier times. There are artifacts and places that have been manipulated to be productive despite severe drought. COVID-19 disrupted the writing of this article, and the authors felt it appropriate to include Nyoongar responses to …

Anti-Uterine Fibroid Effect Of Standardized Labisia Pumila Var. Alata Extracts In Vitro And In Human Uterine Fibroid Cancer Xenograft Model, Norfahana Zakaria, Khamsah S. Mohd, Mohammed A. A. Saeed, Loiy E. A. Hassan, Armaghan Shafaei Darestani, Fouad S. R. Al-Suede, Abdul H. Memon, Zhari Ismail

Research outputs 2014 to 2021

Background: Uterine fibroids are a common type of solid tumor presenting in women of reproductive age. There are very few alternative treatment available from conventional treatment involving surgeries. Labisia pumila var. alata or locally known as ‘Kacip Fatimah’ was widely used as traditional medicine in Malaysia. This plant has been used to maintain a healthy female reproductive system. The present study aimed to evaluate anti fibroid potential of L. pumila extracts through in vitro apoptosis activity against uterine leiomyoma cells (SK-UT-1) and in uterine leiomyoma xenograft model. Evaluation of bioactive markers content were also carried out. Methods: Apoptotic induction of …

Our Hopes For Nutritional Psychiatry And Fatphobia: An Exploration Of The Difficulties And Potential For Interdisciplinary Study, Casey Troost

The Synapse: Intercollegiate science magazine

No abstract provided.

The Journal Of Undergraduate Research: 2019

The Journal of Undergraduate Research

This is the complete issue of the South Dakota State University Journal of Undergraduate Research, Volume 17.

The Effect Of Neonicotinoid Clothianidin On Ring-Necked Pheasant Survival And Reproduction, Michael Sundall

Electronic Theses and Dissertations

Ring-necked pheasants (Phasianus colchicus) are economically important to the state of South Dakota bringing in over one hundred million dollars in revenue each season. The population is known to fluctuate temporally for many reasons, often weather related. Unfortunately, no research has been conducted involving ring-necked pheasants that evaluated the impact or interaction of neonicotinoids on the species. The objective of our study was to gain an understanding of how the neonicotinoid, Clothianidin, affects survival and breeding in pheasants. Our first experiment was to determine if there was a selection bias for seeds treated with neonicotinoids. In this experiment, eight ring-necked …

Biophysical And Socioeconomic Impacts Of Farmer Managed Natural Regeneration In Burkina Faso, Basnewende Brice Fulgence Zoungrana

Electronic Theses and Dissertations

Human actions such as overgrazing, the development of cities at the expense of forests, high intensity and poor agricultural management, and so forth, reduce the resources available for future generations. Because Earth has limited resources, it is important to judiciously use and manage natural resources. Human actions towards nature are the focus of my research in Africa. Increased demands for grazing, agriculture, and ecosystem services led some farmers in developing countries to use unsustainable practices, which may lead to low incomes and poor food nutrition for households. Farmer managed natural regeneration (FMNR) may be a solution to these issues. FMNR …

Antidiabetic Activity Of Cissus Rotundifolia Plant Growing In Saudi Arabia, Saad Ali Alshehri

Electronic Theses and Dissertations

Diabetes mellitus (DM) is a metabolic disease characterized by high levels of blood glucose resulting from defects in insulin production or action. A world-wide increase in the diabetes rate is projected to reach pandemic levels over the next 10-20 years. Current data shows that high numbers of the population in Saudi Arabia suffer from diabetes and prediabetes. Non-traditional treatments of diabetes from medicinal plants has shown potential antidiabetic activity. A considerable percentage of the population still prefer or use medicinal plants as a treatment or supplement to traditional medicine. Cissus rotundifolia (family Vitaceae) is a known plant in southwestern Saudi …

An Analytical Examination On The Effects Of Vegetarian And Omnivorous Diets On C-Reactive Protein, Aletha Kleis

Undergraduate Honors Theses

There is a lack of research regarding how following a vegetarian or omnivores diet effects C-Reactive Protein (CRP) levels of people as seen through results from an analysis of data gathered from the National Health and Nutrition Examination Survey (NHANES). The level of CRP is a reflection of how much inflammation there is in one’s body and is a popular indicator of risk for heart disease. Thus, in this research, I use the NHANES data to look at the relationship of CRP levels of people who identified themselves as vegetarian or not, while also considering the general healthiness of each …

Heavy Metal Contamination In Groundwater And Surface Water Due To Active Pb-Zn-Cumine Tails And Water-Rock Interactions: A Case Study From The Küre Mine Area (Turkey), Tülay Ekemen Keski̇n, Emre Özler

Turkish Journal of Earth Sciences

This study aimed at elucidating the groundwater and surface water pollution resulting from water-rock interaction, mine tailings, and mining activities at Küre (Kastamonu) sulfidic Pb-Zn-Cu mine area and its vicinity. The study area has a surface area of approximately 2990 km2. The Küre River drainage site covering the study area is approximately 440 km2. The concentrations of SO4, Al, As, Ba, Mn, Ni, Sb, and Pb in some groundwater (K10, K20, K21, K27, K28, K29, K30), and surface water (KR3) exceed the maximum limit values with respect to the Turkish Standards for Water Intended For Human Consumption and World Health …

Winter Patch Grazing, Patch Burn Grazing, And Bird Communities In Western South Dakota, Jennifer Lutze

Electronic Theses and Dissertations

Ground nesting bird species are on a considerable decline and research efforts are being made to increase these populations throughout the Great Plains. Ground nesting bird communities found in the Northern Great Plains are driven greatly by varying amounts of cover and area size. Past research implemented patch-burn grazing to increase structural heterogeneity and to increase grassland bird habitat in the tallgrass prairie. While bird populations were very responsive to this management in the Northern Great Plains fire management is viewed negatively, especially for Midwest cattle ranchers. We implemented research to determine if winter-patch grazing on mixed grass prairie could …

Phytoremediation Of Saline-Sodic Soils In East Central South Dakota Utilizing Perennial Grass Mixtures, Douglas J. Fiedler

Electronic Theses and Dissertations

Several decades of above average precipitation in South Dakota has increased the area of saline and sodic soils, which reduce crop yields and inhibit sensitive plant growth. Saline and sodic soils are difficult to remediate using traditional agricultural crops. Establishing salt tolerant perennial species may restore productivity to salt affected areas. Two perennial grass mixtures (mix 1: slender wheatgrass, beardless wildrye; mix 2: slender wheatgrass, western wheatgrass, green wheatgrass, creeping meadow foxtail) were dormant frost seeded along a topographic gradient in Clark Co., SD. Soils were Forman-Cresbard loam and a Cresbard-Cavour loam with surface electrical conductivity (EC_1:1) that …