Digital Commons Network^™

Molecular Assembly Of Hyaluronic Acid Nanoparticles For Drug Delivery By Molecular Dynamics Simulation, Pisit Lerttanakij

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nanoparticles (NPs) offer a promising approach in modern medicine for the treatment of various diseases. They serve as effective carriers for various drugs including antibiotics, antivirals and anticancer agents. Hyaluronic acid-based nanoparticles (HA-NPs) have been interested owing to their exceptional biocompatibility and biodegradability. Hyaluronic acid (HA) is a natural biopolymer with versatile applications. However, there have been limited numbers of studies on molecular simulations of nanoparticles, particularly HA-NPs. In this study, molecular dynamics simulations were employed to explore molecular models representing the assembly of HA-NPs. Two types of HA-NPs, acetylated hyaluronic acid nanoparticles (AcHA-NPs) and hyaluronic acid-ceramide nanoparticles (HACe-NPs), were …

Phytochemical Of Dioscorea Bulbifera For Cosmeceuticals, Shabnam Pari

Chulalongkorn University Theses and Dissertations (Chula ETD)

People across various cultures have utilized plant-based substances to enhance their appearance, and cosmetics with active agents to lighten skin tone has been used. Skin whitening practices typically involve chemical constituents designed to reduce melanin and oxidative stress. People worldwide prefer using natural products to enhance their appearance due to its safety and less side effects. The intake of plant-derived bioactive agents has become increasingly popular due to their health benefits. Different forms of plants contain varying quantity of bioactive compounds. For example, drying, a common method of food preparation, significantly impacts the quantity of these compounds. Fresh and dried …

Microalgal-Plant Growth Promoting Bacterial Living Biofilters As Soil Amendment For Vegetable Cultivation, Augustine Odibo

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study explored the use of microalgal-plant growth-promoting bacterial co-cultures as living biofilters (Chlorella vulgaris (CV) and Bacillus subtilis (BS) in different ratios) for soil amendment in vegetable cultivation. It aimed to investigate the soil amendment potential of these biofilters on three selected plants (i.e. morning glory, sunflower, and cucumber) over a 20-days plantation in a controlled environment. The highest biomass yields of morning glory, cucumber, and sunflower were 1.3 ± 0.1 g, 2.0 ± 0.3 g, and 1.5 ± 0.2 g when using CV/BS 1:1, CV/BS 3:1, and CV/BS 3:1 respectively. For sunflower, the biomass yield with CV/BS 1:1, …

Ultrasonic-Assisted Extraction Of Andrographolide And Bioactive Diterpene Lactones From Andrographis Paniculata, Ayomide Gbadebo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Andrographis paniculata is an herbaceous plant known for its medicinally active diterpene lactones, including andrographolide (AG), neoandrographolide (NAG), 14-deoxy-11,12-didehydroandrographolide (DDHAG), and 14-deoxyandrographolide (DAG). These compounds are typically extracted using polar solvents like methanol and ethanol, yielding ≤4% w/w. This research focused on combining a fairly polar solvent with a highly polar solvent in an ultrasonic-assisted extraction (UAE) process, which is both time and energy efficient. The optimized conditions for the extraction were 40°C, 3 hours, 50% duty cycle, 1:10 solute-solvent ratio using a 6:4 ratio of ethyl acetate to ethanol, and 180W power. Quantitative nuclear magnetic resonance (qNMR) analysis successfully …

The Future Of Meat Substitutes For Sustainable Food System: Insights From Chinese Consumer Preference And Role Of Agenda Setting, Wenxuan Guo

Chulalongkorn University Theses and Dissertations (Chula ETD)

The future of meat substitutes for China's sustainable food system was examined in this dissertation. Influence of media agenda-setting, consumer perception, preferences, and experts' opinions towards sustainable meat systems were investigated by text mining, online questionnaire survey, and stakeholder in-depth interviews. Integration of the agenda-setting concerning meat substitutes with the 2022 Chinese government dietary policy and the influence of articles in mainstream news is recommended. The research findings contribute to bridging the gap between policy formulation, agenda-setting, and public perception and suggest that media provide information consistently with the national food policy and provide education and knowledge correctly and clearly. …

Digital Sustainable Livelihoods And Displacement: A Study Of Myanmar Mixed Migrants In Mae Sot, Thailand, Thinn Nadi Soe

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study explores how digital tools enhance sustainable livelihoods for Myanmar mixed migrants in Thailand and examines how digital resources integrate into livelihood strategies for self-reliance and socio-economic well-being using a modified Sustainable Livelihood Framework. Insights from key informants’ experiences, and stakeholder perspectives reveal that mixed migrants leverage strong human and social capital, showing adaptability and resilience, which can lead to sustainable livelihoods with digital engagement. However, major challenges in financial stability, digital access, natural resources, and social inclusion require further support.

Carnivore And Ungulate Occurrence In A Fire-Prone Region, Sara J. Moriarty-Graves

Cal Poly Humboldt theses and projects

Increasing fire size and severity in the western United States causes changes to ecosystems, species’ habitat use, and interspecific interactions. Wide-ranging carnivore and ungulate mammalian species and their interactions may be influenced by an increase in fire activity in northern California. Depending on the fire characteristics, ungulates may benefit from burned habitat due to an increase in forage availability, while carnivore species may be differentially impacted, but ultimately driven by bottom-up processes from a shift in prey availability. I used a three-step approach to estimate the single-species occupancy of four large mammal species: mountain lion (Puma concolor), coyote …

Longitudinal Sport Science Implementation In American Collegiate Men’S Basketball, Jason Stone

Graduate Theses, Dissertations, and Problem Reports (ETD)

The expanding opportunities to implement sport science frameworks in elite-level basketball environments coincide with the sport’s increasing global prominence. Concomitant to these opportunities is the continual growth of the sport technology market (e.g., wearables, force plates) and computational power (e.g., data management tools, coding capabilities), which yields solutions and challenges for both athletes and practitioners. Due to the rapid influx of new sport technologies in high performance environments, particularly American Collegiate Men’s Basketball, more formal and ecologically valid research on how to effectively utilize data derived from them, particularly over long periods of time (i.e., multiple seasons) is needed. To …

Utilizing Proteomics To Identify And Optimize Microalgae Strains For High-Quality Dietary Protein: A Review, Sara Hamzelou, Damien Belobrajdic, James A. Broadbent, Angéla Juhász, Kim L. Chang, Ian Jameson, Peter Ralph, Michelle L. Colgrave

Research outputs 2022 to 2026

Algae-derived protein has immense potential to provide high-quality protein foods for the expanding human population. To meet its potential, a broad range of scientific tools are required to identify optimal algal strains from the hundreds of thousands available and identify ideal growing conditions for strains that produce high-quality protein with functional benefits. A research pipeline that includes proteomics can provide a deeper interpretation of microalgal composition and biochemistry in the pursuit of these goals. To date, proteomic investigations have largely focused on pathways that involve lipid production in selected microalgae species. Herein, we report the current state of microalgal proteome …

Proteome Changes Resulting From Malting In Hordein-Reduced Barley Lines, Mahya Bahmani, Angéla Juhász, Utpal Bos, Mitchell G. Nye-Wood, Malcolm Blundell, Crispin A. Howitt, Michelle L. Colgrave

Research outputs 2022 to 2026

Hordeum vulgare L., commonly known as barley, is primarily used for animal feed and malting. The major storage proteins in barley are hordeins, known triggers of celiac disease (CD). Here, sequential window acquisition of all theoretical mass spectra (SWATH)-MS proteomics was employed to investigate the proteome profile of grain and malt samples from the malting barley cultivar Sloop and single-, double-, and triple hordein-reduced lines bred in a Sloop background. Using a discovery proteomics approach, 2688 and 3034 proteins were detected from the grain and malt samples, respectively. By utilizing label-free relative quantitation through SWATH-MS, a total of 2654 proteins …

Ambient Ammonia Synthesis Via Microwave-Catalytic Materials And Plasma Chemistry, Siobhan Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ammonia is critical to supporting human life on earth because of its use as fertilizer. The Haber-Bosch process to produce ammonia has been practiced for over 100 years. This process operates at high pressure and temperature to overcome the thermodynamic and kinetic limitations of the ammonia synthesis reaction thus researchers have tried to overcome it for decades. At present this process represents 1% of global energy usage and 2.5% of global CO₂ emissions. The proposed chemical looping ammonia synthesis approach seeks to reduce the environmental impact of this critical process and to elucidate microwave-catalytic principles.

This research aims to …

Imaging Supermolecular Interactions Of The Pharmaceutical- Cocrystal Of Apigeninnicotinamide Binding With Serum Albumin, Yuting Sun, Ming Guo, Xiaoxue Zhao, Ronghui Wu

Turkish Journal of Chemistry

In this paper, a new pharmaceutical cocrystal was synthesized using apigenin (AP) and pharmaceutically acceptable conformer nicotinamide (Nico), and the drug delivery between AP-Nico pharmaceutical cocrystal and human serum albumin (HSA) in vivo was studied at atomic scale. The pharmaceutical cocrystal was characterized using Fourier-transform infrared (FTIR) spectroscopy, 1H NMR spectroscopy, differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD), and the self-assembling mechanism was explored. The dissolution and cumulative release in vitro were investigated. Molecular dynamic (MD) simulation combined with fluorescence spectroscopy was used to study the delivery mechanism of AP-Nico to HSA. The results showed that AP was …

Effect Of Okra Bast Fillers On Biodegradation Properties Of Poly(Vinyl Alcohol) Composites, Gazi Md Arifuzzaman Khan, Nazi̇re Deni̇z Yilmaz

Turkish Journal of Chemistry

This paper focuses on the effect of okra bast fillers on biodegradation of poly(vinyl alcohol) composites. Fibers were obtained from okra plant stems via biological degumming and subjected to different chemical treatments such as scouring, alkalizing, maleic anhydride treatment, and vinyl acetate grafting. The fibers were ground and PVA-okra bast filler composites were produced at 20 wt% fiber load via the solution casting method. The obtained composites were tested in terms of mechanical properties and exposed to biodegradation in soil. Effects of okra bast filler addition and chemical treatments on changes in mass, breaking strength, elasticity modulus, and breaking elongation …

Sustainable Utilisation And Management Of Food Waste For High-Value Products, Amit Jaiswal

Articles

Welcome to the Special Issue on “Sustainable Utilisation and Management of Food Waste for High-Value Products”. This Special Issue focuses on one of the most critical challenges facing our world today—the efficient management and utilisation of food waste. It presents a variety of scientific investigations from renowned scholars and researchers worldwide to address this challenge, covering an array of topics ranging from fundamental research to real-world applications. Food waste is a global dilemma that requires urgent attention. According to the Food and Agriculture Organization (FAO), approximately one-third of food produced for human consumption worldwide, or around 1.3 billion tons, is …

Biophysical Interactions Control The Progression Of Harmful Algal Blooms In Chesapeake Bay: A Novel Lagrangian Particle Tracking Model With Mixotrophic Growth And Vertical Migration, Jilian Xiong, Jian Shen, Qubin Qin, Michelle C. Tomlinson, Yinglong J. Zhang, Xun Cai, Fei Yi, Linlin Cui, Margaret R. Mulholland

OES Faculty Publications

Climate change and nutrient pollution contribute to the expanding global footprint of harmful algal blooms. To better predict their spatial distributions and disentangle biophysical controls, a novel Lagrangian particle tracking and biological (LPT-Bio) model was developed with a high-resolution numerical model and remote sensing. The LPT-Bio model integrates the advantages of Lagrangian and Eulerian approaches by explicitly simulating algal bloom dynamics, algal biomass change, and diel vertical migrations along predicted trajectories. The model successfully captured the intensity and extent of the 2020 Margalefidinium polykrikoides bloom in the lower Chesapeake Bay and resolved fine-scale structures of bloom patchiness, demonstrating a reliable …

Middle Savannah River: An A/R/Tographic Ecopedagogical Ethnography Experimenting With Rhizomatic Perspectives, Lisa Augustine-Chizmar

College of Graduate Studies: Theses & Dissertations

This research is an experiment in perspective. Using the four commonplaces (Schwab, 1978), I practiced letting the Savannah River teach me what there is to know about the water, the land, the people, and the other entities that depend on ki through artistic, ethnographic, and ecopedagogical lenses. The ethnographic findings describe the social actors that depend on ki and give a voice to the River. The a/r/tographic findings display the River on a canvas map through two hundred years using paint, clay, photography, video, abstract acrylics, and fabric. Together, these methods contribute to a unique ecopedagogical journey. This word cloud …

In Vitro Tyrosinase Inhibitory, Dna Interaction Studies, And Lc?Hrms Analysis Of Ficus Carica Leaves, Güli̇n Renda, Burak Barut, Rümeysa Ceren, Enes Aydin

Turkish Journal of Chemistry

Turkey is the world?s leading producer of figs, a typical Mediterranean fruit. The fig, Ficus carica L. (Moraceae), has been widely cultivated since ancient times due to the nutritional value of its fruits. It was aimed to investigate the phytochemical characterization and biological properties of F. carica leaf extracts in order to determine their potential for use in the treatment of various diseases. F. carica leaves were extracted in 70% methanol at 40 °C under reflux. To obtain extracts of different polarities, the crude extract was fractionated with n-hexane, dichloromethane, and n-butanol. Phenolic content was determined using liquid chromatography?high resolution …

Navigating Opportunities To Improve Youth Outcomes In A Least Developed Country: An Action Research Study, Naomi Docilait

Antioch University Dissertations & Theses

The ambitious United Nations-adopted Sustainable Development Goals (SDGs) require the concentrated effort of governments, the business sector, and other key stakeholders, including women and youth, for its success. Effective leadership will be essential for different sectors to integrate these development goals into strategic plans and operational activities in the service of realizing this agenda by 2030. Unfortunately for Least Developed Countries (LDCs), the COVID-19 pandemic caused the worst economic outcomes in 30 years. For this group of countries, the pandemic has negatively influenced efforts to eradicate poverty and improve social outcomes. This setback makes achieving the Sustainable Development Goals by …

Preface : Fruit And Vegetable Waste Utilization And Sustainability, Sachin A. Mandavgane, Ipsita Chakravarty, Amit Jaiswal

Books/Book Chapters

Fruits and vegetables are an important source of nutrition and a key element of a healthy balanced diet. Several organizations such as the World Health Organization (WHO), Food and Agriculture Organization of United Nations (FAO), and Food Health England suggest consuming more than 400 g of fruits and vegetables per day (roughly five portions per day) to improve overall health and reduce the risk of certain cardiovascular diseases and cancer; subsequently, consumption and production of fruits and vegetables are on the rise. The increased consumption/production of fruits and vegetables has resulted in huge quantities of waste (approximately 42% of the …

Pro-Environmental Diversification Of Pasture-Based Dairy And Beef Production In Ireland, The United Kingdom And New Zealand: A Scoping Review Of Impacts And Challenges, Maria Markiewicz-Keszycka, Aileen Carter, Donal O'Brien, Maeve Henchion, Simon Mooney, Paul Hynds

Articles

Grass-fed dairy and beef products are valued by consumers for their unique nutrient profile, enhanced animal welfare and lower environmental footprint compared to conventional produce derived from animals reared indoors on higher volumes of concentrate feeds (O'Callaghan et al., Reference O'Callaghan, Vázquez-Fresno, Serra-Cayuela, Dong, Mandal, Hennessy, McAuliffe, Dillon, Wishart, Stanton and Ross2018; Moscovici Joubran et al., Reference Moscovici Joubran, Pierce, Garvey, Shalloo and O'Callaghan2021). For the current study, pasture-based production of dairy and beef is defined as a system within which cattle graze freely outdoors on green pasture for ≥6 months per year, using grazed grass as the primary feed …

Selection And Characterization Of Bacteriocinogenic Lactic Acid Bacteria From The Intestine Of Gilthead Seabream (Sparus Aurata) And Whiting Fish (Merlangius Merlangus): Promising Strains For Aquaculture Probiotic And Food Bio-Preservation, Sarah Cheriet, Sana Lenglitz, Amel Romdhani, Paul Hynds, Mohamed Salah Abbassi, Taofik Ghrairi

Articles

This study sought to evaluate the probiotic properties and the food preservation ability of lactic acid bacteria isolates collected from the intestines of wild marine fishes (gilthead seabream (Sparus aurata) (n = 60) and whiting fish (Merlangius merlangus) (n = 40)) from the Mediterranean sea in the area of Mostaganem city, Algeria. Forty-two isolates were identified as: Enterococcus durans (n = 19), Enterococcus faecium (n = 15), Enterococcus faecalis (n = 4), Lactococcus lactis subp. lactis (n = 3), and Lactobacillus plantarum (n = 1). All isolates showed inhibition to at least one indicator strain, especially against Listeria monocytogenes, Staphylococcus …

Co-Design Of An Interactive Wellness Park: Exploring Design Requirements For A Multimodal Outdoor Physical Web Installation With Older Adults, Fatima Badmos

Academic Posters Collection

The global demographic landscape is experiencing a notable shift, characterised by a growing proportion of adults over 60. According to projections, the proportion of individuals aged 60 and above is expected to reach one-sixth of the global population by 2030. Furthermore, by 2050, this demographic is projected to exceed a staggering two billion people. Amidst this shift, there is an urgent need to develop interactive and innovative solutions to address older adults' unique challenges, particularly in outdoor physical activity.

A co-design methodology involving older adults’ participation from the idea generation to the application development process will be adopted to address …

Development Of A Scoring Tool For Australian Rural Food Retail Environments, Tracy L. Schumacher, Carissa A. Alderton, Leanne J. Brown, Susan Heaney, Laura Alston, Katherine Kent, Stephanie L. Godrich

Research outputs 2022 to 2026

Current tools scoring the healthiness of food retail outlets do not reflect outlets found in rural locations. This study aimed to adapt pre-existing Australian scoring tools to represent non-metropolitan areas. Rural nutrition experts were identified, and a modified Delphi technique was used to adapt two pre-existing, food-scoring tools in five iterative stages. Stages included identifying all relevant outlets, providing a description and score for each, ensuring consistency between outlet scores and pre-existing, metro-centric tools, and providing instructions for correct use. Six rural nutrition experts were identified and engaged in the modified Delphi technique. The final tool consisted of 12 categories …

Natural Product Co-Metabolism And The Microbiota–Gut–Brain Axis In Age-Related Diseases, Mark Obrenovich, Sandeep Kumar Singh, Yi Li, George Perry, Bushra Siddiqui, Waqas Haq, V. Prakash Reddy

Chemistry Faculty Research & Creative Works

Complementary alternative medicine approaches are growing treatments of diseases to standard medicine practice. Many of these concepts are being adopted into standard practice and orthomolecular medicine. Age-related diseases, in particular neurodegenerative disorders, are particularly difficult to treat and a cure is likely a distant expectation for many of them. Shifting attention from pharmaceuticals to phytoceuticals and "bugs as drugs" represents a paradigm shift and novel approaches to intervention and management of age-related diseases and downstream effects of aging. Although they have their own unique pathologies, a growing body of evidence suggests Alzheimer's disease (AD) and vascular dementia (VaD) share common …

Natural Product Co-Metabolism And The Microbiota–Gut–Brain Axis In Age-Related Diseases, Mark Obrenovich, Sandeep Kumar Singh, Yi Li, George Perry, Bushra Siddiqui, Waqas Haq, V. Prakash Reddy

Chemistry Faculty Research & Creative Works

Complementary alternative medicine approaches are growing treatments of diseases to standard medicine practice. Many of these concepts are being adopted into standard practice and orthomolecular medicine. Age-related diseases, in particular neurodegenerative disorders, are particularly difficult to treat and a cure is likely a distant expectation for many of them. Shifting attention from pharmaceuticals to phytoceuticals and "bugs as drugs" represents a paradigm shift and novel approaches to intervention and management of age-related diseases and downstream effects of aging. Although they have their own unique pathologies, a growing body of evidence suggests Alzheimer's disease (AD) and vascular dementia (VaD) share common …

Ecological Niche Comparison Among Closely Related Tree Species Of Lauraceae Using Climatic And Edaphic Data, Laura J. Giraldo-Kalil, Gonzalo E. Pinilla Buitrago, Andrés Lira-Noriega, Francisco Lorea-Hernández, Juan Núñez-Farfán

Publications and Research

ABSTRACT:

Edaphic specialization is considered to promote ecological differentiation among closely related species of Damburneya (Lauraceae) occurring in sympatry. However, little is known about the effects of soil and other key environmental factors like climate on the ecological niche and distribution of these tree species. Here, we assessed the role of climate and soil on niche divergence and potential distribution of four Damburneya species whose distributions span Central America and Mexico. We performed ecological niche modeling with MaxEnt using three sets of environmental data: climatic-only, edaphic-only, and a combination of both, to characterize species niches and suitable distribution areas. Niche …

Unequal Trust: Bottled Water Consumption, Distrust In Tap Water, And Economic And Racial Inequality In The United States, Daniel Jaffee

Sociology Faculty Publications and Presentations

Reviewing public health, nutrition, and social science literature, this article examines how bottled water consumption and spending in the United States differ along lines of race, ethnicity, and income, how these consumption patterns have changed in recent years, and how those shifts map onto perceptions of the safety and trustworthiness of tap water supplies, both before and since the Flint water disaster. It also addresses the differential impact of bottled water spending on household income. The findings challenge the truism that bottled water consumption is positively correlated with income, instead showing a bimodal racial and class consumption pattern that reflects …

Mass Spectrometry-Based Proteomic Analysis To Characterise Barley Breeding Lines, Mahya Bahmani

Theses: Doctorates and Masters

Barley is a key ingredient in the malting and brewing industry, and it is the fourth most important crop being cultivated worldwide. The protein content of the barley grain is one of the main components determining the quality and nutritive value of the food and beverages prepared from barley. Mass spectrometry-based proteomic analysis is a valuable tool that can guide and inform plant breeding strategies and crop improvement programs. Understanding the proteome changes in barley grain under different growing locations, the impact of different environmental conditions and its relationship with malting characteristics have the potential to inform breeding programs to …

The Potential And Limitations Of Conversational Agents For Chronic Conditions And Well-Being, Ekaterina Uetova, Lucy Hederman, Robert J. Ross, Dympna O'Sullivan

Articles

Conversational agents are becoming more common in the health and wellness domains in part due to assumptions regarding potential improvements in individuals’ outcomes. This paper presents initial findings from a review of conversational agent use in healthcare for chronic conditions and well-being. A search of the literature was performed on electronic databases PubMed, ACM Digital Library, Scopus and IEEE Xplore. Studies were included if they were focused on chronic disorder management, disease prevention or lifestyle change and if systems were tested on target user groups. This paper investigates the health domains, the user profiles and reasons why conversational agents may …

The Effects Of Post-Harvest Residue On Plantation Forest Soils And Early Growth Of Redwood And Douglas-Fir Seedlings In Humboldt County California, Robert W. Raibley

Cal Poly Humboldt theses and projects

Forest harvest residue (slash) usefulness has been up for debate among private timberland owners, public land managers, and the timber industry for decades. The disposal of slash, viewed as having low ecological value, has received considerable attention as wildfire risk has made burning it harder. In recent years, forest scientists and ecologists have recognized the importance of decaying wood and its relationship to forest growth and regeneration. At this site in Northern California, we looked at whether forest harvest residue enriches soil near slash windrows through soils coring and lab analyses, looking for primary limited nutrients nitrate (NO₃-N) …