Digital Commons Network^™

Versatile Imidazole Scaffold With Potent Activity Against Multiple Apicomplexan Parasites, Monique Khim, Jemma Montgomery, Mariana Laureano De Souza, Melvin Delvillar, Lyssa J. Weible, Mayuri Prabakaran, Matthew A. Hulverson, Tyler Eck, Rammohan Y. Bheemanabonia, P. Holland Alday, David P. Rotella, J. Stone Doggett, Bart L. Staker, Kayode K. Ojo, Purnima Bhanot

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Malaria, toxoplasmosis, and cryptosporidiosis are caused by apicomplexan parasites Plasmodium spp., Toxoplasma gondii, and Cryptosporidium parvum, respectively, and pose major health challenges. Their therapies are inadequate, ineffective or threatened by drug resistance. The development of novel drugs against them requires innovative and resource-efficient strategies. We exploited the kinome conservation of these parasites to determine the cellular targets and effects of two Plasmodium falciparum inhibitors in T. gondii and C. parvum. The imidazoles, (R)-RY-1-165 and (R)-RY-1-185, were developed to target the cGMP dependent protein kinase of P. falciparum (PfPKG), orthologs of which are present in T. gondii and C. parvum. Using …

Enhancing Multi-Step Stock Price Forecasting With Social Media Sentiment And Engagement Metrics, Damilare Olaniyan

Electronic Theses and Dissertations

This thesis investigates whether social media sentiment can improve the accuracy of stock price prediction beyond traditional historical data. While financial markets have long relied on structured numerical indicators, the growing influence of public discourse on platforms like Twitter has introduced new opportunities for extracting market-relevant signals from unstructured text. The study focuses on four major technology firms and combines sentiment features derived from Twitter with historical stock prices in a hybrid machine learning framework. Engagement-weighted sentiment, linguistic complexity, and polarity intensity were extracted using natural language processing techniques and incorporated into classification and regression models. Results show that including …

Photochemistry Of Quinones And Combustion-Derived Particles, Desiree J. Sarmiento

Electronic Theses and Dissertations

Quinones are ubiquitous species that can be produced from the photochemical aging of combustion-derived particles (CDPs). Polycyclic aromatic hydrocarbons (PAHs) are a major component of CDPs and are precursors to quinones and other oxidized products (OPAHs). My work first expanded on the PAH and OPAH photochemistry research of Dr. John Haynes, who showed that anthracene (ANT) oxidizes into 1,4-naphthoquinone (1,4-NAPQ), 1,4-anthraquinone (1,4-ANTQ), and 9,10-anthraquinone (9,10-ANTQ), and of Dr. Heather Runberg, who demonstrated the ability of ANT and these quinones to generate reactive oxygen species (ROS). Then at the Pacific Northwest National Laboratory (PNNL), I was given the opportunity to investigate …

Synthesis Of Anti-Schistosomal Heterocyclic Compounds Targeting Thioredoxin Glutathione Reductase, Alexander Stewart

Lawrence University Honors Projects

chistosomiasis is a deadly and debilitating parasitic disease caused by Schistosoma mansoni which affects 200+ million people annually who come into contact with contaminated water. Currently only one drug (Praziquantel) has been used to treat this disease for almost 50 years, and fear of resistance is growing, thus a new drug and new target is needed. Inhibition of the organism-specific redox defense protein Thioredoxin Glutathione Reductase (TGR) has lead to the death of the worm in vitro, indicating that it would be a good druggable target. Fragment based analysis and x-ray crystallography have returned the outline of a lead compound …

Simple Yet Effective, Effective Yet Inclusive: A Skincare Line, Ayesha Wali Rahimoon

Lawrence University Honors Projects

This honors project addresses the lack of inclusive skincare formulations by developing a scientifically grounded skincare line with an antioxidant-rich serum, moisturizer, and cleanser tailored to support diverse skin types, particularly melanin-rich skin. The serum combines strawberry extract powder, Manuka honey, niacinamide, green tea extract, and humectants to promote hydration, antioxidant protection, and skin barrier reinforcement. Formulated with a stable pH of 5.0–5.5 and an effective preservative system, the product was tested through non-animal, biologically relevant models.

A UV protection assay using HEK293 cells demonstrated that the serum significantly reduces oxidative damage, increasing post-exposure cell viability to 80%, compared to …

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …

Re: Comment Letter For The Final Butte Reduction Works (Brw) Smelter Area Waste Remediation And Contaminated Groundwater Hydraulic Control Site Air Monitoring Quality Assurance Project Plan (Qapp) For Interim Demolition Activities (Dated May 19, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Western Kentucky University Stormwater Utility Survey 2025, Warren Campbell

SEAS Faculty Publications

This survey provides data on 2147 U.S. and 82 Canadian stormwater utilities. The data is intended to provide useful data to communities that wish to enact stormwater utilities. Different fee systems are examined with the goal of avoiding legal exposure. Recently, the major source of pre-disaster mitigation funds was eliminated. States should consider state-wide stormwater utilities to make up for this loss.

Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Non-Residential Parcels And Residential Daycares), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Critical Plastocapillary Number For A Newtonian Liquid Filament Embedded Into A Viscoplastic Fluid, Mohammad Tanver Hossain, Wonsik Eom, Arjun Shah, Andrew Lowe, Douglas Fudge, Sameh H. Tawfick, Randy Ewoldt

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The yield stress of a viscoplastic material can stabilize an embedded fluid tunnel against capillarity-induced breakup, enabling remarkable technologies such as embedded 3D printing of intricate, freeform, and small components. However, there is persistent disagreement in the published literature between the observed minimum stable diameter, 𝑑min, and the theoretical plastocapillary length 𝑝𝑐 = 2𝛤∕𝜎𝑦, with interfacial tension 𝛤 and bath yield stress 𝜎𝑦, leading to a prior hypothesis that the apparent surface tension 𝛤 is much smaller to enforce 𝑑min = 𝑝𝑐 . Here we introduce and experimentally test a new hypothesis that the critical diameter is set by the …

Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li

Faculty Publications

Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …

Structural Analysis Of The Aileu Metamorphic Complex And The Laclo Fault Of Timor Leste, Banda Arc-Continent Collision, Emma C. Morrison

Theses and Dissertations

This study presents a structural analysis of the brittle and ductile features within the Aileu Metamorphic Complex of Timor Leste, located in the active Banda Arc–Australian continental collision zone. The deformation history of the complex is interpreted from the Permian–Jurassic deposition of sediments and basalts into intra-arc basins of Gondwana, through to the present- day collision of the Australian continental margin. This collision led to the development of the Wetar Suture and subsequent back-thrusting of the Aileu metamorphic rocks northward over the Banda forearc. Field evidence confirms that the Laclo Fault is currently active, with the most recent movement exhibiting …

Virtual Reality’S Impact On Tourist Attitudes In Islamic Religious Tourism: Exploring Emotional Attachment And Vr Presence, Eman Alkhalifah, Ramy Hammady, Mahmoud Abdelrahman, Alyaa Darwish, Ella Cranmer, Ons Al-Shamaileh, Aikaterini Bourazeri, Timothy Jung

All Works

This study explores the integration of immersive technologies, specifically virtual reality (VR), to enhance tourist experiences in the rapidly expanding religious tourism sector. Despite VR’s potential, limited research has examined its impact on religious tourism. This study addresses this gap by investigating the role of emotional attachment in influencing VR presence during pre-, on-site, and postexperiences of VR-mediated religious tourism. A quantitative survey was conducted with 201 respondents who participated in VR religious tourism activities. The empirical analysis, conducted using SPSS and AMOS structural equation modeling (SEM), assessed how VR-mediated religious tourism impacts VR presence and tourist attitudes before actual …

How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred

Theses and Dissertations

Using semi-structured interviews this research explored the experiences of transitioning autistic adults with online communication. Participants shared information about navigating online communication, highlighting specific challenges such as interpreting tone and sarcasm, managing unspoken social norms, like emoji use, and responding to ambiguous or unexpected interactions. Participants shared that misunderstandings do occur in their online communication and how they recognize those miscommunications and strategize around preventing and mitigating them. These findings reveal that while computer-mediated communication offers opportunities for connection, it also presents unique obstacles that can exacerbate feelings of frustration due to miscommunications or misunderstandings. To prevent these social frictions …

Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch

Theses and Dissertations

The morphological structure of Semitic languages like Arabic and Hebrew is based on non-concatenative roots and templates. This complex word structure used by humans is obscured to neural models that use traditional tokenization algorithms. In this work, I present and evaluate Semitic Root Encoding (SRE), a tokenization method that represents Semitic words with distinct root and template stem tokens, and apply it to neural machine translation (NMT). I evaluate whether tokenization with the SRE method leads to increases in translation quality, whether it allows NMT models to hypothesize unseen word forms needed at inference, and how impervious resulting NMT models …

Comparative Analysis Of Matrix Factorization And Neural Collaborative Filtering For Movie Recommendation Systems, Mahyar Alinejad

Data Science and Data Mining

This paper presents a comparative study of two recommendation system approaches for predicting movie ratings: Matrix Factorization with Stochastic Gradient Descent (SGD) optimization and Neural Collaborative Filtering (NCF) using Tensor Flow. The study aims to evaluate the effectiveness of these methods in recommending movies to users based on the MovieLens 100K dataset. The Matrix Factorization approach utilizes latent features to model user preferences and item characteristics, optimizing parameters through SGD. On the other hand, NCF integrates traditional collaborative filtering with neural networks to capture complex user-item interactions. Experimental results demonstrate the performance of both models in terms of Root Mean …

Effects Of Elevated Temperatures On Tooth Structure During Polymerization Of Composite Resin With A Variety Of Light Sources, Enas G. Yonis

Al-Bahir

This study investigated the impact of high temperatures on dental tissues during the polymerization of optical fillings using a diode laser and two types of pulsed and continuous LED devices. Three distinct light source units were employed: a laser diode, an LEDition, and a LED.B. Temperature increases were measured at a distance of 1 mm from the thermocouple to the tip of the device. To create an experimental model, we fixed the operational voltage of the polymerization device and maintained a 1 mm gap between the terminal and the thermocouple wire. Temperature readings and thermal background (TO) measurements were taken …

Building And Demonstrating A Framework And Guide For Human-Centered Threat Modeling, Warda Usman

Theses and Dissertations

As researchers increasingly seek to understand threats faced by people rather than systems, there remains little consensus on how to study these threats in ways that are grounded in human experience. Traditional approaches to threat modeling are often designed for system vulnerabilities and offer limited guidance for eliciting or analyzing threats as understood by individuals in their social and cultural contexts. This dissertation addresses this gap by advancing human-centered threat modeling (HCTM) in security and privacy research as both a conceptual framework and through a set of empirical studies. The dissertation employs a mixed set of qualitative methods across four …

Cannabis Concentrate Vaping Chemistry, Kaelas R. Munger, Killian M. Anreise, Robert M. Strongin

Chemistry Faculty Publications and Presentations

Background:

This review article addresses the vaping chemistry of manufactured cannabis concentrates—a topic that remains under-researched despite the widespread availability and growing popularity of these products. Given their current prevalence and the fact that many of the findings discussed herein are from early-stage investigations, further research is essential to fully assess the public health risks associated with concentrate use. The purpose of this article is to help begin to bridge this knowledge gap by outlining the technical challenges of studying cannabis concentrates and to present evidence-based data concerning toxicant exposures as a foundation for future investigations.

Methods:

A search of …

Draft Final 2025 Residential Metals Abatement Program (Rmap) Quality Assurance Project Plan (Qapp) Annual Update (Residential Parcels), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Tellings Of The Pacific Ocean: A Landscape-Based Approach For Multispecies Design And Hci, Maliheh Ghajargar

Engineering Faculty Articles and Research

Environmental disturbances induced by climate change have caused significant changes in our ecosystems and are threatening the health of our environments. As a response to this issue, a growing body of work has emerged in HCI and design, which seeks to foreground more-than-human stories in support of making more sustainable and just futures. This research contributes to this broad agenda by probing graphic novels as a multispecies storytelling method for design and HCI. Combining ideas from Anna Tsing’s adventures of landscape and from HCI and design’s use of sequential art (e.g., storyboards), we use landscape as the main protagonist of …

Development And Photophysical Characterization Of Bioinspired Materials, Qaisar Maqbool

USF Tampa Graduate Theses and Dissertations

Porphyrins are versatile aromatic macrocycles with unique photophysical properties that make them attractive for applications in light harvesting, photocatalysis, and sustainable energy conversion. Incorporating porphyrins into metal-organic frameworks (MOFs) offers a unique opportunity to modulate their photophysical behavior through spatial confinement and host–guest interactions. This thesis explores how structural modifications influence porphyrin excited-state behavior through a multi-stage investigation. The work begins by comparing the photophysical properties of two cationic porphyrins: tetra(N-methylpyridyl) porphyrin(TMPyP) and tetra(4-N,N,N-trimethylanilinium) porphyrin(4TANP). While TMPyP exhibits significant singlet–charge transfer (S₁–CT) state mixing due to charge delocalization onto peripheral pyridinium groups, 4TANP lacks comparable behavior. The localized nature of …

Pathology’S Place In Understanding The Bias And Inequalities In Women’S Healthcare, Andrea Heaney, Eugene Hickey, Emma Murphy

SAML-25 Workshop on Statistical and Machine Learning

Women’s healthcare is a complex, multifaceted issue with both historic and implicit biases, along with biological differences between men and women. With the advancement of AI tools in healthcare and the potential for biased data to create biased models, it is vital to consider how women are represented in data. Previously conducted semi-structured semantic interviews with clinicians were analysed via Braun and Clark’s method of thematic analysis. The analysis of these interviews yielded the following themes: Gender Influencing Health, Pregnancy, Social Factors, General Health, Treatment, Training, and Research. These themes highlight that context is key to understanding the biases in …

A Framework For Scalable And Controlled Hallucination Data Collection, Lin Ting Liang

Computer Science Senior Theses

This thesis addresses a key bottleneck in hallucination research: the scarcity and limitations of hallucination benchmark datasets. Existing datasets typically focus on a single type of hallucination and are expensive to produce due to the need for manual prompt creation and annotation. To overcome these challenges, we propose a novel mixture-of-experts (MoE) adversarial framework that actively induces hallucinations. Our framework employs three large language model (LLM) agents that iteratively and adversarially revise prompts to provoke hallucinated responses from a target question-answering model. It automates the generation of both intrinsic hallucinations (logical inconsistencies) and extrinsic hallucinations (inclusion of unverifiable external information). …

Character Relationship Prediction In Movies: Toward Emotionally-Aware Automatic Audio Descriptions, Seung Hyun Hahm

Computer Science Senior Theses

Automatic audio description (AD) systems support visually impaired audiences by narrating visual content, but they often fail to capture the interpersonal dynamics that underpin narrative understanding. In this work, we introduce a novel framework for character relationship prediction as a means of enriching audio descriptions with socially grounded context. Our contributions are threefold: (1) we propose the Character Relationship Module (CRM), which extends identity-aware video captioning with directed sentiment inference between character pairs; (2) we develop a scalable weak supervision pipeline that uses large language models to generate 669,520 relationship annotations across 202 films; and (3) we construct a complementary …

A First Look Into Parental Strategies, And Challenges Around Children’S Device Usage In Urban Nepal, Rizu Paudel, Prakriti Dumaru, Ankit Shrestha, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

There have been substantial changes in the landscape of technology use by children in Global South during COVID-19, when the shift to online learning platforms necessitated parents to avail personal devices (e.g., smartphones, computers) for their children to fulfill their educational needs. However, the use of devices by children are not limited to serving educational purpose only. Our study positions itself in a critical post-pandemic period in Nepal, characterized by the increase in device use by children, while a little study to date, investigated parental mediation in this developing country. To this end, we conducted semi-structured interviews with 20 parents, …

An Approach To Stylometry Using Causal Language Models, Harrison F. Stropkay

Computer Science Senior Theses

We present a novel stylometric approach using large language models. By training separate models on individual authors' works, we find that each model achieves lower cross-entropy loss when predicting text from its training author compared to other authors' texts. Moreover, for any given text, the model trained on its true author’s corpus yields the lowest loss. We suggest that, in this way, a model trained on one author's works embodies the unique writing style of that author. We demonstrate our approach on works by eight known authors. This approach also confirms that R. P. Thompson wrote the well-studied 15th book …

Artificial Intelligence And Astronomy: Lab Manual For Generative Ai-Based Learning Activities, Vasiliy Znamenskiy

Open Educational Resources

This lab manual introduces community college students to the intersection of artificial intelligence (AI) and astronomy through hands-on, inquiry-based activities. It explores how generative AI platforms—ranging from text-based chat systems to image and video generators—can enhance scientific understanding, creativity, and critical thinking in space science education. Students engage with tools such as ChatGPT, Gemini, DALL·E, and Synthesia to formulate and evaluate astronomy-related questions, generate scientifically inspired visualizations, and produce dynamic representations of cosmic phenomena. Through structured exercises, the manual promotes digital literacy, fosters analytical skills, and illustrates how AI assists in astronomical research, including data analysis, image enhancement, spacecraft autonomy, …

Investigation Of A Polymer-Based Holographic Grating For Visible Light Dosimetry Using A Bleachable Dye, Saoirse Maher, Denise Denning, Jackie Mccavana Dr., Seán Cournane Dr., Suzanne Martin Dr., Dervil Cody

Conference Papers

Holographic sensors are of interest for a range of sensing tasks because of their high sensitivity, rapid response time, broad dynamic range, lightweight characteristics, and design flexibility. The practical application of holography makes it possible to design optical sensors that are effective in the visible and near-infrared ranges. The objective of this research is to construct a holographic grating that is customised to provide quantitative data in visible light dosimetry applications. Upon exposure to visible light, the proposed holographic grating will produce a measurable change in diffraction efficiency based on the bleaching of the grating material. In the evolution of …

Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski

Publications and Research

Recognizing that libraries serve multiple constituencies and subject areas, this chapter documents and advocates for development of transdisciplinary arts-based research (ABR) and culture-related projects linked to environmental challenges. Libraries contribute collections and spaces, as well as the research of library and information scientists. Libraries are currently among invisible contributors to sustainability planning and services. The chapter will link this invisibility to the value of what visual arts refer to as negative space elements in subjects ranging from traditional ecological knowledge to environmental science. Library collections, projects, and research contribute to education for sustainable development (ESD) as required to achieve the …