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Effects Of Synthetic Blood Plasma On Calcium Dependent Dimerization Of Ncad12, Brent Treadway

Honors Theses

Neural Cadherin (NCAD) is one of three Type 1 vertebral classical cadherins that function as the primary transmembrane component in cell-to-cell interactions at adherens junctions. Adhesive interactions mediated by this protein are calcium dependent with three calcium-binding sites between each of its five extracellular domains. NCAD is very important in many cell-to-cell interactions because of its function in development and in immune and neurological synapses. Generally, in vitro studies of calcium dependent dimerization of NCAD are conducted in a nonphysiological buffer (NaCl + HEPES: SEC buffer). In order to study dimerization in more physiologically relevant conditions, I created a synthetic …

Effects Of Inbreeding On Endangered Red Wolves (Canis Rufus), Kristin E. Brzeski

LSU Doctoral Dissertations

Inbreeding depression, the reduction in offspring fitness caused by mating among close relatives, is widespread in small populations and a major concern in conservation biology because it can affect population persistence. The negative effects of inbreeding results in the evolution of inbreeding avoidance behaviors; within small populations, such behaviors may encourage individuals to select mates outside of their respective species. Mate choice may also be facilitated by variation at major histocompatibility complex (MHC) genes, a gene group critical for immune response and disease resistance. Given broad impacts of inbreeding and MHC variation on fitness and behavior, evaluating their effects is …

2,4-Disubstituted Quinazolines With Antileishmanial Or Antibacterial Activity, Megan Marie Barber

USF Tampa Graduate Theses and Dissertations

Herein 47 2,4-disubstituted quinazolines were synthesized and tested against Leishmania donovani intracellular amastigotes. A structure-activity relationship was conducted and lead to the identification of quinazolines with EC50s in the single digit and high nanomolar range with favorable antileishmanial selectivity indexes. Quinazoline 2.6 and 2.31 underwent in vivo efficacy studies in murine models of visceral leishmaniasis, reducing liver parasitemia by 12 % and 24 %, respectively, when given by the intraperitoneal route at 15 mg/kg/day x 5 days. The antileishmanial efficacy and easy of synthesis make the 2,4-disubstituted quinazoline compound series a suitable platform for the future development of antileishmanial agents. …

Sheep Updates 2015 - Ravensthorpe, Bruce Mullan, Kate Pritchett, Kimbal Curtis, Chris Wilcox, Mike Hyder, Leigh Sonnerman, Lynne Bradshaw, Geoff Lindon, Katherine Davies, Joe Young, Stephen Lee, Ian Robertson, Lucy Anderton, Hayley Norman, Ed Barrett-Lenard, Jackie Jarvis, Ben Patrick

Sheep Updates

This session covers fourteen papers from different authors:

1. The Sheep Industry Business Innovation project, Bruce Mullan, Sheep Industry Development Director, Department of Agriculture and Food, Western Australia

2. Western Australian sheep stocktake, Kate Pritchett and Kimbal Curtis, Research Officers, Department of Agriculture and Food, Western Australia

3. Wool demand and supply - short term volatility, long term opportunities, Chris Wilcox, Principal of Poimena Analysis

4. Lifetime management for maternal ewes, Mike Hyder, Research Officer, Department of Agriculture and Food, Western Australia

5. National Livestock Identification System (NLIS) for sheep and goats - what is the NLIS database? Leigh Sonnermann, …

Traditional Livestock Production And Growth Opportunities In India, S. M. Deb

IGC Proceedings (1977-2023)

Livestock and animal health development projects need to be based on an understanding of livestock production systems because different systems need different approaches particularly in view of degradation of environment combined with population pressure. In India, the livestock production system is primarily traditional, consisting of mixed-farming and pastoral systems, therefore, development of marginal and smallholder mixed farms must aim at intensification of the total production system. Resource-poor farming systems may aim at the improved management of the various livestock species in backyards. Pastoral systems must focus on effective management of grazing pressure. Community pasture management involves application of technologies, land …

Analysis And Simulation For Homogeneous And Heterogeneous Sir Models, Joseph Wilda

Electronic Theses and Dissertations

In mathematical epidemiology, disease transmission is commonly assumed to behave in accordance with the law of mass action; however, other disease incidence terms also exist in the literature. A homogeneous Susceptible-Infectious-Removed (SIR) model with a generalized incidence term is presented along with analytic and numerical results concerning effects of the generalization on the global disease dynamics. The spatial heterogeneity of the metapopulation with nonrandom directed movement between populations is incorporated into a heterogeneous SIR model with nonlinear incidence. The analysis of the combined effects of the spatial heterogeneity and nonlinear incidence on the disease dynamics of our model is presented …

Refraction In Mozambique: Evaluations Of Practice And Development Of Competency Frameworks For Eye Care Personnel, Kajal Shah

Doctoral

Purpose The development of competency- based education for optometrists and mid-level eye-care personnel has been identified as an important component in the elimination of avoidable blindness and vision impairment. The Mozambique Eye care Project (MEP) is a multi-institutional collaboration, which seeks to facilitate greater access to training in eye health professions, which will ultimately contribute to providing affordable and accessible eye care within the public health system in Mozambique. An important tenet of the MEP is to develop and enhance the refraction training of all existing (ophthalmic technicians) and new eye care personnel (four-year training of optometrists and eighteen-month training …

Climate Change Implications For Health-Care Waste Incineration Trends During Emergency Situations, Emilia Mmbando Raila

Walden Dissertations and Doctoral Studies

Healthcare waste (HCW) incineration practices in the global South countries are among the major sources of black carbon (BC) emissions or smoke. This study analyzes HCW incineration trends during emergency situations and smoke from HCW incineration processes in Haiti. The study was prompted by the current arguments about the climate change and the growing health effects associated with BC emissions. The conceptual framework was based on both adverse health effects from BC emissions exposure and climate change potential of BC emissions. Therefore, the goal was to determine whether cardboard HCW sharps containers emit lower BC emissions to the atmosphere during …

Studying Cellular And Molecular Interaction With Two-Photon Fluorescence Microscopy, Arifur Rahaman

Open Access Theses & Dissertations

Advances in microscopy and fluorescent probes provide new insight into studying cellular and molecular interactions. Two-photon fluorescence microscopy is one of the most important recent inventions in cellular and molecular study. This technology enables noninvasive study at cellular and molecular levels in three dimensions with submicrometer resolution. Two-photon excitation of fluorophores results from the simultaneous absorption of two photons. This excitation process has a number of unique advantages, such as reduced specimen photodamage and enhanced penetration depth. In this study, we used our two-photon microscope to observe predatorial behavior of fast moving bacterivorous marine organism Cafeteria roenbergensis and quantify Mycobacterium …

The Meteorological Conditions Affecting The Propagation Of Respiratory Diseases, Rosette Maria Gonzalez

Open Access Theses & Dissertations

Valley Fever, also known as Coccidioidomycosis, is endemic of the US Southwest. In 2012 this disease was the second most-reported disease in Arizona, according to the New Yorker January 2014 edition. The Paso Del Norte Region (PdN) is a semi-arid region with significant agricultural acreage and Valley Fever is known to be a threat in this region. It is our goal in this Thesis work to apply an existing PBL Height Program (e.g., Liu, et.al.) to the Paso Del Norte Region (PdN) to study the effect it has in the transmission of Valley Fever. Obtaining the PBLH as it evolves …

Bounded Rationality In Decision Making Under Uncertainty: Towards Optimal Granularity, Joseph Anthony Lorkowski

Open Access Theses & Dissertations

Starting from well-known studies by Kahmenan and Tversky, researchers have found many examples when our decision making seems to be irrational. We show that this seemingly irrational decision making can be explained if we take into account that human abilities to process information are limited. As a result, instead of the exact values of different quantities, we operate with granules that contain these values. On several examples, we show that optimization under such granularity restriction indeed leads to observed human decision making. Thus, granularity helps explain seemingly irrational human decision making.

Similar arguments can be used to explain the success …

Exploratory Study Of Seasonal Indoor Bioaerosols And The Associated Health Outcomes In Low-Income Communities In El Paso, Texas, 2014, Eric Martinez

Open Access Theses & Dissertations

Introduction: Structural degradation, moisture levels, and building failures can influence poor indoor air quality and create a good environment for bioaerosols. People spend much of their time indoors and can potentially be exposed to these bioaerosols. Several studies have correlated exposures to high concentrations of bioaerosols to various health problems, severe allergies, asthma, or other respiratory illness. Objectives: The objectives of this study are to describe bioaerosol concentrations, meteorological factors, and health outcomes during the summer and fall seasons; characterize bioaerosols (bacteria and fungi) collected in low-income communities; compare bioaerosol concentrations by season; compare meteorological factors to bioaerosol concentrations by …

A Continuous Process Towards The Synthesis Of Quinolones, Stevara N. Clinton

Theses and Dissertations

Abstract

The development of quinolones is described from the first quinolone to the latest fluoroquinolones. Quinolones have generated considerable interest since their discovery because of their antibacterial capabilities. Analogs incorporating the 4-quinolone ring system comprise a largely expanding group of synthetic compounds. The development of antibacterial resistance has created the need for an efficient synthesis of quinolones that can be easily adapted toward the assembly of quinolone based antibacterial drugs.

There are several reported approaches to the 4-quinolone ring system. Many of these methods use expensive starting materials, require the removal of high boiling solvents, or use high temperature conditions …

Development Of Orally Bioavailable 4(1H)-Quinolones And 1,2,3,4-Tetrahydroacridin-9(10H)-Ones With Potent Anti-Malarial Activity, Jordany Richarlson Maignan

USF Tampa Graduate Theses and Dissertations

Although Malaria rates are on the decline due to the efforts of the World Health Organization and other organizations dedicated to the eradication of this disease, a relaxed attitude towards the development of new antimalarial entities would be flawed. Due to the emergence of resistance in the parasite, the almost 50% world-wide reduction in malarial death rates that have been produced over the past 15 years are threatening to be lost

New drugs are urgently needed and our approach focuses on the re-evaluation and optimization of the historic antimalarial ICI 56,780. Due to its causal prophylactic activity, along with its …

A Survey Of Mathematical Models Of Dengue Fever, Iurii Bakach

College of Graduate Studies: Theses & Dissertations

In this paper, we compare and contrast five models of Dengue fever. We evaluate each model using different scenarios and identify the strenghts and wecknesses of each of the model

Online Diagnosis Of Diabetes With Twitter Data, Farheen Ali

Masters Theses

"Innovation in technology enables people to communicate, share information and look for their needs by just sitting in rooms and going through some clicks. While social media has played a very important role in connecting people worldwide, its potential has stretched beyond the innovative idea of connecting people through their social networks. While many thought there was no meeting point for the healthcare sector and social media, it was a surprise when research and innovations have shown that social media could lay a very significant role in the health care sector.

Research has been done in developing models that could …

Saccharomyces Boulardii And Bismuth Subsalicylate As Low-Cost Interventions To Reduce The Duration And Severity Of Cholera, Johnathan Sheele, Jessica Cartowski, Angela Dart, Arjun Poddar, Shikha Gupta, Ajay Gupta

Computer Science Faculty Publications

We conducted a randomised single-blinded clinical trial of 100 cholera patients in Port-au-Prince, Haiti to determine if the probiotic Saccharomyces cerevisiae var. boulardii and the anti-diarrhoeal drug bismuth subsalicylate (BS) were able to reduce the duration and severity of cholera. Subjects received either: S. boulardii 250 mg, S. boulardii 250 mg capsule plus BS 524 mg tablet, BS 524 mg, or two placebo capsules every 6 hours alongside standard treatment for cholera. The length of hospitalisation plus the number and volume of emesis, stool and urine were recorded every 6 hours until the study subject was discharged (n=83), left against …

Small Business Sustainability In The Salon Industry, Militea Johnson-Hilliard

Walden Dissertations and Doctoral Studies

Small businesses fail at high rates; 51% fail to succeed in business beyond the first 5 years. The purpose of this exploratory case study was to explore the strategies that salon business owners used to succeed in business. The sample comprised of 2 salon business owners in Savannah, Georgia who have been in business more than 5 years. The conceptual framework was based on the general systems theory. Data were collected from conducting semistructured interviews with each business owner, a review of company business plans, direct observation of participants during client interaction in the salon, as well as member-checking interview …

Correlation Analysis Of Climatic Variables, Migration And Dengue Cases In Southeast Florida, Brunilda Lugo

Walden Dissertations and Doctoral Studies

Dengue fever is a debilitating, viral, mosquito-borne disease occurring in tropical and subtropical areas in the world. The majority of dengue cases in the United States were acquired in endemic areas by travelers or immigrants. However, in recent years, autochthonous (locally acquired) dengue cases have been diagnosed in Florida. The purpose of this study was to find an association between potential risk factors and the expansion of dengue fever in the United States. Guided by the eco-bio-social framework, which offers a broad assessment of risk factors for the illness, a retrospective design was used with archival data to correlate changes …

An Appraisal Of Experiences Of Climate Change And Adaptive Response To Heat Stress By Farmers In Rural Ghana, Kwasi Frimpong

Theses: Doctorates and Masters

With the increase in average global temperatures, heat-related illnesses and deaths have unfolded as occupational and health issues. Periods of high to extreme temperatures are becoming more common and are a leading cause of weather-related deaths in many countries. In agricultural settings of African countries, heat stress is a major concern as many smallholder farmers work outdoors with limited access to cooling systems even in their resting and living environments. This study, conducted in the Bawku East part of Northern-East Ghana in 2013, examines, in the context of climate change, the trends and impacts of heat stress on smallholder farmers, …

The Lived Experiences Of Limited English Proficiency, Spanish-Speaking Male Ex-Offenders, Paula Nery Sanchez

Walden Dissertations and Doctoral Studies

The purpose of this phenomenological study was to explore the lived experiences of Spanish-speaking men in the United States with limited English proficiency following their release from prison. The study specifically examined the experiences of these men in their efforts to access health care treatment, housing, education, and employment in Central Pennsylvania. An empirical, phenomenological research design was employed that used self-stigma, critical race, and self-determination theories for in-depth interviews with 8 men who spent 5 to 24 years in prison. A tiered coding method was used to generate 6 interconnected themes that tell the story of these men's lives: …

Rural Year-Round Growing To Ameliorate A Possible Negative Effect From Climate Change, Kimberlie A. Brussa

Walden Dissertations and Doctoral Studies

The Intergovernmental Panel on Climate Change (IPCC) suggested that, as the world population grows, food and water shortages will become even more serious issues (IPPC's 2014 predictions about the future effects of climate change (CC), Year-round growing (YRG) may provide a way for communities to extend growing seasons, expand local farm systems, and provide food year round. This case study included a detailed analysis of responses from representatives of all sectors of rural Mesa County, Colorado, regarding YRG and a local food and farm plan due to CC. The case was bounded by time (6 months of data collection) which …

The Value Of Diagnostic Software And Doctors' Decision Making, Babatunde Ayodele Alaofin

Walden Dissertations and Doctoral Studies

The prevalence of medical misdiagnosis has remained high despite the adoption of diagnostic software. This ongoing controversy about the role of technology in mitigating the problem of misdiagnosis centers on the question of whether diagnostic software does reduce the incidence of misdiagnosis if properly relied upon by physicians. The purpose of this quantitative, cross-sectional study based on planned behavior theory was to measure doctors' opinions of diagnostic technology's medical utility. Recruitment e-mails were sent to 3,100 AMA-accredited physicians through their database that yielded a sample of 99 physicians for the study. One-sample t tests and, where appropriate because of non-normal …

Mono-N-Acyl-2,6-Diaminopimelic Acid Derivatives: Analysis By Electromigration And Spectroscopic Methods And Examination Of Enzyme Inhibitory Activity, Jan Hlaváček, Miloslava Vítovcová, Petra Sázelová, Jan Pícha, Václav Vaněk, Miloš Buděšínský, Jiří Jiráček, Danuta M. Gillner, Richard C. Holz, Ivan Mikšík, Václav Kašička

Chemistry Faculty Research and Publications

Thirteen mono-N-acyl derivatives of 2,6-diaminopimelic acid (DAP)—new potential inhibitors of the dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18)—were analyzed and characterized by infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies and two capillary electromigration methods: capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC). Structural features of DAP derivatives were characterized by IR and NMR spectroscopies, whereas CZE and MEKC were applied to evaluate their purity and to investigate their electromigration properties. Effective electrophoretic mobilities of these compounds were determined by CZE in acidic and alkaline background electrolytes (BGEs) and by MEKC in acidic and alkaline BGEs …

Differences In The Diversity Of Frogspecies Between Sierra Lloronaand El Valle, Panama, Kei Okabe Thurber

Independent Study Project (ISP) Collection

Panama is home to the greatest diversity of species in all of Central America. It is home to 174 species of frogs, 35 of which are endemic to Panama. Frogs are a vital part of many ecosystems. They maintain insect populations and act as food sources for larger predators. Their job of maintaining insect populations is essential to curbing the spread of diseases. Additionally, scientists have found chemical compounds in the skin of frogs that can be used to treat pain and prevent infections. The main threat to the majority of frogs is the deadly fungus Batrachochytrium dendrobatidis (Bd), or …

Antifungal Amphiphilic Aminoglycoside K20: Bioactivities And Mechanism Of Action, Sanjib K. Shrestha, Cheng-Wei Tom Chang, Nicole Meissner, John Oblad, Jaya P. Shrestha, Kevin N. Sorensen, Michelle M. Grilley, Jon Y. Takemoto

Chemistry and Biochemistry Faculty Publications

K20 is a novel amphiphilic antifungal aminoglycoside that is synthetically derived from the antibiotic kanamycin A. Reported here are investigations of K20′s antimicrobial activities, cytotoxicity, and fungicidal mechanism of action. In vitro growth inhibitory activities against a variety of human and plant pathogenic yeasts, filamentous fungi, and bacteria were determined using microbroth dilution assays and time-kill curve analyses, and hemolytic and animal cell cytotoxic activities were determined. Effects on Cryptococcus neoformans H-99 infectivity were determined with a preventive murine lung infection model. The antifungal mechanism of action was studied using intact fungal cells, yeast lipid mutants, and small unilamellar lipid …

Comparing Disease Prevalence In Hard Corals At Four Different Reefs Near The Island Of Narganá In The Guna Yala Comarca Of Panamá, Connor Hinton

Independent Study Project (ISP) Collection

Coral reefs harbor much of the world’s known marine biodiversity. For a number of reasons, coral reefs are becoming increasingly threatened. Large portions of the world’s reefs have already been lost, and the number of degrading reefs is constantly on the rise. One cause for the destruction of coral reefs are coral diseases, ultimately causing coral mortality. With the death of corals, a key species is lost, endangering the entire reef ecosystem. Documenting the presence of such diseases could be useful in assessing current reef health and ameliorating the growing threat of coral diseases. In this project, 18 40m2 belt …

The Potentials And Challenges Of Big Data In Public Health, Rena N. Vithiatharan

Australian eHealth Informatics and Security Conference

The potential to use big data sources for public health increases with the broadening availability of data and improved methods of analysis. Whilst there are some well-known examples of the opportunistic use of big data, such as GoogleFlu, public health has not yet realised the full potential of such data sources. A literature review was undertaken to identify the potential of such data collections to impact public health, and to identify what challenges are currently limiting this potential. The potential include improved real-time analysis, research and development and genome studies. However, challenges listed are poor universal standardisation and classification, privacy …

Big Data In Healthcare: What Is It Used For?, Rebecca Hermon, Patricia A H Williams

Australian eHealth Informatics and Security Conference

Big data analytics is a growth area with the potential to provide useful insight in healthcare. Whilst many dimensions of big data still present issues in its use and adoption, such as managing the volume, variety, velocity, veracity, and value, the accuracy, integrity, and semantic interpretation are of greater concern in clinical application. However, such challenges have not deterred the use and exploration of big data as an evidence source in healthcare. This drives the need to investigate healthcare information to control and reduce the burgeoning cost of healthcare, as well as to seek evidence to improve patient outcomes. Whilst …

Long Wavelength Analysis Of A Model For The Geographic Spread Of A Disease, Layachi Hadji

Applications and Applied Mathematics: An International Journal (AAM)

We investigate the temporal and spatial evolution of the spread of an infectious disease by performing a long-wavelength analysis of a classical model for the geographic spread of a rabies epidemic in a population of foxes subject to idealized boundary conditions. We consider twodimensional and three-dimensional landscapes consisting of an infinite horizontal strip bounded by two walls a finite distance apart and a horizontal region bounded above and below by horizontal walls, respectively. A nonlinear partial differential evolution Equation for the leading order of infectives is derived. The Equation captures the space and time variations of the spread of the …