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Split Aptameric Turn-On Fluorescence Sensor For Detection Of Sequence Specific Nucleic Acid At Ambient Temperature, Nanami Kikuchi Jan 2018

Split Aptameric Turn-On Fluorescence Sensor For Detection Of Sequence Specific Nucleic Acid At Ambient Temperature, Nanami Kikuchi

Electronic Theses and Dissertations

Nucleic acid amplification tests (NAATs) enable sensitive detection of low density infections that microscopy and rapid diagnostic test are not capable of detecting. They enable quantitative and qualitative nucleic acid detection, genotype analysis, and single nucleotide polymorphism (SNP) detection. Current state of the art molecular probes used with NAATs includes molecular beacon (MB), Taqman and its variations. This work presents novel molecular probe designed from Spinach and Dapoxyl aptamers. The aptamers are split into two parts (split aptamer), allowing greater sensitivity and selectivity towards fully complementary nucleic acid analyte. The major advantage of split aptamer probe over state-of-the-art fluorescent probes …

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Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai Jan 2018

Detection Of Sulfonamide Residues By Paper Spray Mass Spectrometry, Surased Suraritdechachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Sulfonamide antibiotics are commonly used veterinary drugs in livestock to prevent or treat infectious diseases. Their residues in food are of concern since they can cause adverse health effects and development of bacterial resistance. In this work, a practical method for detection and quantification of sulfamethazine, one of sulfonamide antibiotics, in pig body fluid samples is developed via the combination of simple extraction and paper spray mass spectrometry. The method required minimal sample preparation and low analysis time while providing high sensitivity and accuracies in pig whole blood (LOD = 10.1 ng/mL, %recovery = 95.4-104.1%), pig serum (LOD = 4.6 …

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Evaluation Of Ispe For Inhibitor Design In The Non-Mevalonate Pathway, Kataryzna Barbara Hoerchler Jan 2018

Evaluation Of Ispe For Inhibitor Design In The Non-Mevalonate Pathway, Kataryzna Barbara Hoerchler

Graduate Research Theses & Dissertations

There is an urgent need to discover new antibiotics to combat the emergence of drug resistant Novel antibiotics that target unique pathways different from existing therapies are promising targets. The non-mevalonate pathway (MEP), which was discovered in the 1990’s, is essential for most bacteria, plants and apicomplexan parasites. Inhibition of the non-mevalonate is an attractive pharmaceutical target, since it is not present in mammals. Many compounds have surfaced as potential inhibitors, but none have made it to market. This thesis investigates the fourth step in the MEP pathway involving the enzyme 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Escherichia coli (Ec), Burkholderia thailandensis …

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The Enzymatic Activity And Inhibition Of Dape Encoded N-Succinyl-L,L-Diaminopimelic Acid Dessucinylase, Tahirah Heath Jan 2018

The Enzymatic Activity And Inhibition Of Dape Encoded N-Succinyl-L,L-Diaminopimelic Acid Dessucinylase, Tahirah Heath

Dissertations

The bacterial enzyme DapE is a hydrolase in the late stage of the mDAP/lysine biosynthetic pathway that catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (L,L-SDAP) to succinic acid and L,L-diaminopimelate (DAP). The product DAP is ultimately converted to m-DAP and then to lysine which is used in the construction of proteins, whereas for humans, lysine is an essential amino acid obtained through diet. DapE has been shown to be conserved across many strains of bacteria. The m-DAP produced through the succinylase pathway is used by both gram negative and gram-positive bacteria in the construction of the essential peptidoglycan cell wall. Because …

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Spatial Modelling And Wildlife Health Surveillance: A Case Study Of White Nose Syndrome In Ontario, Lauren Yee Jan 2018

Spatial Modelling And Wildlife Health Surveillance: A Case Study Of White Nose Syndrome In Ontario, Lauren Yee

Theses and Dissertations (Comprehensive)

Wildlife data is often limited by survey effort, small sample sizes, and spatial biases associated with collection and missing data. These factors can create unique challenges from a surveillance perspective when trying to extract spatial patterns of habitat suitability and disease distributions for conservation and management purposes. This thesis examined data quality from a wildlife health database in the context of spatial analysis of wildlife disease. Spatial analysis of the data to predict habitat suitability of bats and white nose syndrome afflicted bats was examined by using the MaxEnt modelling method. Methods to reduce spatial bias were examined and specific …

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Connecting Chemistry To Community With Deliberative Democracy, Regis Komperda, Jack Barbera, Erin Shortlidge, Gwen Shusterman, Stem Education And Equity Institute, Portland State University Jan 2018

Connecting Chemistry To Community With Deliberative Democracy, Regis Komperda, Jack Barbera, Erin Shortlidge, Gwen Shusterman, Stem Education And Equity Institute, Portland State University

Biology Faculty Publications and Presentations

Science education communities have called for rethinking curricula to improve student understanding of the nature of science and the role of science in addressing controversial modern issues such as climate change, energy policy, and pollution levels. One approach to meeting this call is integrating these topics into class activities that require students to use discussion and scientific approaches to solve problems and deliberate potential policy solutions. Deliberative democracy (DD) is one such active learning approach in which students work in peer groups to reach a consensus on a scientific topic relevant to both real-world issues and course content. During DD …

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Climate Risk Profile: Egypt, Usaid Jan 2018

Climate Risk Profile: Egypt, Usaid

Egypt & Libya

Throughout Egypt’s extensive history, its inhabitants have relied heavily upon the Nile and the productive agricultural sector it nurtures. Modern Egypt has one of the most diversified economies in the Middle East, with robust service, manufacturing, agricultural, and tourism sectors. However, Egypt’s dependence on the Nile River for 95 percent of its freshwater leaves the country vulnerable to climate shocks and transboundary water conflict. Egypt shares land borders with Libya to the West, Israel and the Gaza Strip to the East, and the Sudan to the South. Egypt’s relationship with Ethiopia, home to the source of the majority of the …

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Influences Of Forest Edges And Human Activities On The Dry Season Ranging Patterns Of Chimpanzees (Pan Troglodytes Schweinfurthii) In Nyungwe National Park, Rwanda, Enathe Hasabwamariya Jan 2018

Influences Of Forest Edges And Human Activities On The Dry Season Ranging Patterns Of Chimpanzees (Pan Troglodytes Schweinfurthii) In Nyungwe National Park, Rwanda, Enathe Hasabwamariya

Antioch University Dissertations & Theses

Great apes, our closest biological relatives are threatened globally by the increasing anthropogenic pressures on their habitat. The major threats to the eastern chimpanzees (Pan troglodytes schweinfurthii) are hunting for bush meat and illegal trade in chimpanzee infants, habitat loss or fragmentation and disease transmission (IUCN, 2010). Nyungwe National Park (NNP), Rwanda has a population of chimpanzees that face several threats, including hunting for bushmeat, habitat degradation from forest fires and human-wildlife conflicts, and much of these impacts are concentrated at forest edges. The main objectives of this research were to assess the use of forest edges by chimpanzees along …

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Temperature-Related Mortality Impacts Under And Beyond Paris Agreement Climate Change Scenarios, Ana Maria Vicedo-Cabrera, Yuming Guo, Francesco Sera, Veronika Huber, Carl Friedrich Schleussner, Dann Mitchell, Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Mathilde Pascal, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Díaz, Julio Gonzalez Cruz, Xerxes T. Seposo, Ho Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Martina S. Ragettli, Martin Röösli, Yueleon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel D. Schwartz, Michelle L. Bell, Tranngoc Ngoc Dang, Dung Do Van, C. Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andrew Haines, London School Of Hygiene & Tropical Medicine, London, United Kingdom London School Of Hygiene & Tropical Medicine, London, United Kingdom, Ben G. Armstrong, Kristie L. Ebi, Antonio Gasparrini Jan 2018

Temperature-Related Mortality Impacts Under And Beyond Paris Agreement Climate Change Scenarios, Ana Maria Vicedo-Cabrera, Yuming Guo, Francesco Sera, Veronika Huber, Carl Friedrich Schleussner, Dann Mitchell, Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Mathilde Pascal, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Díaz, Julio Gonzalez Cruz, Xerxes T. Seposo, Ho Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Martina S. Ragettli, Martin Röösli, Yueleon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel D. Schwartz, Michelle L. Bell, Tranngoc Ngoc Dang, Dung Do Van, C. Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andrew Haines, London School Of Hygiene & Tropical Medicine, London, United Kingdom London School Of Hygiene & Tropical Medicine, London, United Kingdom, Ben G. Armstrong, Kristie L. Ebi, Antonio Gasparrini

Articles

The Paris Agreement binds all nations to undertake ambitious efforts to combat climate change, with the commitment to Bhold warming well below 2 °C in global mean temperature (GMT), relative to pre-industrial levels, and to pursue efforts to limit warming to 1.5 °C^. The 1.5 °C limit constitutes an ambitious goal for which greater evidence on its benefits for health would help guide policy and potentially increase the motivation for action. Here we contribute to this gap with an assessment on the potential health benefits, in terms of reductions in temperature-related mortality, derived from the compliance to the agreed temperature …

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Quantifying Excess Deaths Related To Heatwaves Under Climate Change Scenarios: A Multicountry Time Series Modelling Study, Yuming Guo, Antonio Gasparrini, Shanshan Li, Francesco Sera, Ana Maria Vicedo-Cabrera, Micheline De Sousa Zanotti Stagliorio Coêlho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Benjawan Tawatsupa, Kornwipa Punnasiri, Ala Overcenco, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Honda, Yasushi Honda, Yasushi, Xerxes T. Seposo, Ho Young Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Guo, Yue Leon Guo, Yue Leon, Bing Yu Chen, Antonella Zanobetti, Joel D. Schwartz, Tranngoc Ngoc Dang, Dung Do Van, Michelle L. Bell, Ben G. Armstrong, Ebi, Kristie L. Ebi, Kristie L., Shilu Tong Jan 2018

Quantifying Excess Deaths Related To Heatwaves Under Climate Change Scenarios: A Multicountry Time Series Modelling Study, Yuming Guo, Antonio Gasparrini, Shanshan Li, Francesco Sera, Ana Maria Vicedo-Cabrera, Micheline De Sousa Zanotti Stagliorio Coêlho, Paulo Hilário Nascimento Nascimento Saldiva, Éric Lavigne, Benjawan Tawatsupa, Kornwipa Punnasiri, Ala Overcenco, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jouni J.K. Jaakkola, Niilo R.I. Ryti, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Honda, Yasushi Honda, Yasushi, Xerxes T. Seposo, Ho Young Kim, Aurelio Tobías, Carmen Iñiguez Fernández, Bertil Forsberg, Daniel Oudin Åström, Guo, Yue Leon Guo, Yue Leon, Bing Yu Chen, Antonella Zanobetti, Joel D. Schwartz, Tranngoc Ngoc Dang, Dung Do Van, Michelle L. Bell, Ben G. Armstrong, Ebi, Kristie L. Ebi, Kristie L., Shilu Tong

Articles

Background: Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. Methods and findings: We collected historical daily time series of mean temperature and mortality for all causes or nonexternal causes, in periods ranging from January 1, 1984, to December 31, 2015, in 412 communities within 20 countries/regions. We estimated heatwave–mortality associations through a two-stage time series design. Current and future daily mean temperature series were projected under four scenarios of …

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Structure Of The Picornavirus Replication Platform: A Potential Drug Target For Inhibiting Virus Replication, Meghan Suzanne Warden Jan 2018

Structure Of The Picornavirus Replication Platform: A Potential Drug Target For Inhibiting Virus Replication, Meghan Suzanne Warden

Chemistry & Biochemistry Theses & Dissertations

Picornaviruses are small, positive-stranded RNA viruses, divided into twelve different genera. Members of the Picornaviridae family cause a wide range of human and animal diseases including the common cold, poliomyelitis, foot and mouth disease, and dilated cardiomyopathy. The picornavirus genome is replicated via a highly conserved mechanism involving a presumed cloverleaf structure located at the 5’ noncoding region of the virus genome. The 5’ cloverleaf consists of three stem loops (B, C, and D) and one stem (A), which interact with a variety of virus and host cell proteins during replication. In this dissertation, human rhinovirus serotype 14 (HRV-14) SLB …

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Key Enzymes In Cancer: Mechanism Of Action And Inhibition With Anticancer Agents, Debasish Bandyopadhyay, Gabriel Lopez, Stephanie Cantu, Samantha Balboa, Annabel Garcia, Christina Silva, Diandra Valdes Jan 2018

Key Enzymes In Cancer: Mechanism Of Action And Inhibition With Anticancer Agents, Debasish Bandyopadhyay, Gabriel Lopez, Stephanie Cantu, Samantha Balboa, Annabel Garcia, Christina Silva, Diandra Valdes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Several enzymes play significant role in different stages of cancer including proliferation, invasion, metastasis and angiogenesis. Mechanism of actions of a few key enzymes along with their inhibitors have been discussed with particular attentation to riboneucleotide reductase, thymidylate synthease, topoisomerase II, interleukins, cell survival proteins and aminopeptidase N.

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Plasmon-Enhanced Optical Sensing By Engineering Metallic Nanostructures, Peng Zheng Jan 2018

Plasmon-Enhanced Optical Sensing By Engineering Metallic Nanostructures, Peng Zheng

Graduate Theses, Dissertations, and Problem Reports (ETD)

The world’s booming population projected to reach 10 billion by 2050 causes enormous stresses on environmental safety, food supply, and healthcare, which in return threatens human civilizations. One of the most promising solutions lies at innovating point-of-care (POC) sensing technologies to conduct detection of environmental hazards, monitoring of food safety, and early diagnosis of diseases in a timely and accurate manner. The discovery of surface-enhanced spectroscopy in the 1970s has significantly stimulated research on light-matter interaction which gives rise to enhanced optical phenomena such as surface-enhanced Raman scattering (SERS), plasmon-enhanced fluorescence (PEF), and particularly, they have found enormous applications in …

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Range Expansion Of Tick Disease Vectors In North America: Implications For Spread Of Tick-Borne Disease, Daniel E. Sonenshine Jan 2018

Range Expansion Of Tick Disease Vectors In North America: Implications For Spread Of Tick-Borne Disease, Daniel E. Sonenshine

Biological Sciences Faculty Publications

Ticks are the major vectors of most disease-causing agents to humans, companion animals and wildlife. Moreover, ticks transmit a greater variety of pathogenic agents than any other blood-feeding arthropod. Ticks have been expanding their geographic ranges in recent decades largely due to climate change. Furthermore, tick populations in many areas of their past and even newly established localities have increased in abundance. These dynamic changes present new and increasing severe public health threats to humans, livestock and companion animals in areas where they were previously unknown or were considered to be of minor importance. Here in this review, the geographic …

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Waste Management Minimization Strategies In Hospitals, Andrea L. Clark Jan 2018

Waste Management Minimization Strategies In Hospitals, Andrea L. Clark

Walden Dissertations and Doctoral Studies

During the delivery of healthcare services, hospital employees use enormous amounts of water, energy, and nonbiodegradable carcinogenic plastics. In the U.S., hospital staff generate an average of over 7,000 tons of waste per day at an average cost of $0.28 per pound for the disposal of regulated medical trash, which if efficiently managed or reduced, could result in substantial cost savings. Using the organizational learning and the transaction cost economics theories as the conceptual frameworks, the purpose of this qualitative case study was to explore strategies healthcare leaders used to minimize their waste management operational costs. Data were collected using …

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Spatiotemporal Variations In Coexisting Multiple Causes Of Death And The Associated Factors, Emmanuel Oluwatobi Salawu Jan 2018

Spatiotemporal Variations In Coexisting Multiple Causes Of Death And The Associated Factors, Emmanuel Oluwatobi Salawu

Walden Dissertations and Doctoral Studies

The study and practice of epidemiology and public health benefit from the use of mortality statistics, such as mortality rates, which are frequently used as key health indicators. Furthermore, multiple causes of death (MCOD) data offer important information that could not possibly be gathered from other mortality data. This study aimed to describe the interrelationships between various causes of death in the United States in order to improve the understanding of the coexistence of MCOD and thereby improve public health and enhance longevity. The social support theory was used as a framework, and multivariate linear regression analyses were conducted to …

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Development Of A Genotype-By-Sequencing Immunogenetic Assay As Exemplified By Screening For Variation In Red Fox With And Without Endemic Rabies Exposure, Michael E. Donaldson, Yessica Rico, Karsten Hueffer, Halie M. Rando, Anna V. Kukekova, Christopher J. Kyle Jan 2018

Development Of A Genotype-By-Sequencing Immunogenetic Assay As Exemplified By Screening For Variation In Red Fox With And Without Endemic Rabies Exposure, Michael E. Donaldson, Yessica Rico, Karsten Hueffer, Halie M. Rando, Anna V. Kukekova, Christopher J. Kyle

Computer Science: Faculty Publications

Pathogens are recognized as major drivers of local adaptation in wildlife systems. By determining which gene variants are favored in local interactions among populations with and without disease, spatially explicit adaptive responses to pathogens can be elucidated. Much of our current understanding of host responses to disease comes from a small number of genes associated with an immune response. High-throughput sequencing (HTS) technologies, such as genotype-by-sequencing (GBS), facilitate expanded explorations of genomic variation among populations. Hybridization-based GBS techniques can be leveraged in systems not well characterized for specific variants associated with disease outcome to “capture” specific genes and regulatory regions …

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Poverty Rate And Occurrence Of Foodborne Illness Risk Factors In Retail Facilities, Margolite Joseph Cesar Jan 2018

Poverty Rate And Occurrence Of Foodborne Illness Risk Factors In Retail Facilities, Margolite Joseph Cesar

Walden Dissertations and Doctoral Studies

Despite the efforts of food safety regulations and rules, food contamination remains a public health concern and prevalent vehicle of pathogens. This study identifies the predictors of food risk in different types of food establishments in Miami Dade County, Florida during the period November 2014 - November 2016. Guided by the epidemiologic triangle model, this correlational study analyzed the log number of risk factor violations and failure rates controlling for US Census sociodemographic data (2010 to 2014) for the food establishment neighborhoods by using linear and logistic regression. Results indicated that most of food entity types are significant predictors of …

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Patient Satisfaction Management In Office Visits And Telehealth In Health Care Technology, Todd Price Jan 2018

Patient Satisfaction Management In Office Visits And Telehealth In Health Care Technology, Todd Price

Walden Dissertations and Doctoral Studies

Telehealth and remote medical treatments have begun to be more commonly used in healthcare systems. Researchers have theorized that providers' abilities to treat patients are not directly tied to the proximity of the patient to the doctor, but by the identification and treatment of the patient's symptoms. Although the treatment and cure rates are being established within individual health systems and professional medical associations, empirical research is lacking regarding patient satisfaction with this remote treatment situation. The purpose of this quantitative study was to address this gap by examining satisfaction ratings of patients between virtual provider visits and face-to-face provider …

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An Interdisciplinary Approach To The Target Elucidation Of Novel Antibiotic 31g12, Larissa A. Walker Jan 2018

An Interdisciplinary Approach To The Target Elucidation Of Novel Antibiotic 31g12, Larissa A. Walker

Graduate Student Theses, Dissertations, & Professional Papers

Staphylococcus aureus is a Gram-positive bacterial pathogen responsible for nosocomial and community-acquired infections that can quickly acquire antibiotic resistance. We have identified a novel triazole antimicrobial 31G12 based on the natural product core of nonactin isolated from the fermentation of Streptomyces griseus, that is active against many Gram-positive bacteria as well as antibiotic resistant methicillin-resistant S. aureus and vancomycin-resistant Enterococcus. The synthesis and characterization indicate that 31G12 exists as a mixture of two rotamers at room temperature and displays bacteriostatic activity against S. aureus with moderate mammalian cell toxicity. We have currently identified potential protein targets of 31G12 in …

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Detection Of Cyanotoxins (Microcystins/Nodularins) In Hepatic Tissues And Epidermal Mats Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Northeast Florida, Amber Brown Jan 2018

Detection Of Cyanotoxins (Microcystins/Nodularins) In Hepatic Tissues And Epidermal Mats Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Northeast Florida, Amber Brown

UNF Graduate Theses and Dissertations

The St. Johns River (SJR; Jacksonville, FL, USA) is a large, brackish, estuarine system characterized by considerable anthropogenic pollution, recurrent harmful algal blooms (HABs), and diverse toxin-producing cyanobacteria. The most prevalent toxins in SJR water samples are microcystins/nodularins (MCs/NODs). Additionally, the SJR provides critical habitat for a genetically and behaviorally distinct estuarine community of bottlenose dolphins (Tursiops truncatus) that routinely uses and strands in low mesohaline and oligohaline areas of the river. This population has been subject to two unusual mortality events (UME) since 2010 and has since been described as having substantial declines in population health, characterized …

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Particle Filters For State Estimation Of Confined Aquifers, Graeme Field Jan 2018

Particle Filters For State Estimation Of Confined Aquifers, Graeme Field

UNF Graduate Theses and Dissertations

Mathematical models are used in engineering and the sciences to estimate properties of systems of interest, increasing our understanding of the surrounding world and driving technological innovation. Unfortunately, as the systems of interest grow in complexity, so to do the models necessary to accurately describe them. Analytic solutions for problems with such models are provably intractable, motivating the use of approximate yet still accurate estimation techniques. Particle filtering methods have emerged as a popular tool in the presence of such models, spreading from its origins in signal processing to a diverse set of fields throughout engineering and the sciences including …

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Reactive Oxygen Species Generation In Human Cells By A Novel Magnetic Resonance Imaging Contrast Agent, Li Wang, Eric Lin, Mary J. Johansen, Timothy Madden, Edward Felix, Karen S. Martirosyan, Steven J. Frank Jan 2018

Reactive Oxygen Species Generation In Human Cells By A Novel Magnetic Resonance Imaging Contrast Agent, Li Wang, Eric Lin, Mary J. Johansen, Timothy Madden, Edward Felix, Karen S. Martirosyan, Steven J. Frank

Physics & Astronomy Faculty Publications

The novel positive-contrast magnetic resonance imaging (MRI) marker C4 consists of an aqueous solution of cobalt chloride (CoCl 2 ) complexed with the chelator N-acetylcysteine (NAC). We evaluated whether the presence of C4 or its components would produce reactive oxygen species (ROS, including hydroxyl, peroxyl, or other reactive oxygen species) in cultured cells. Human cancer or normal cells were incubated with 1% (w/v) CoCl 2 ·6H 2 O or 2% NAC or a combination of both (1% CoCl 2 ·6H 2 O: 2% NAC in an aqueous solution, abbreviated as Co: NAC) in the presence or absence of H 2 …

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Toxicity Evaluation Of A Novel Magnetic Resonance Imaging Marker Cocl2-N-Acetylcysteine In Rats, Li Wang, Mihai Gagea, Karen S. Martirosyan, Mary Johansen, Timothy Madden, Lisa Norberg, Kirk S. Culotta, Steven J. Frank Jan 2018

Toxicity Evaluation Of A Novel Magnetic Resonance Imaging Marker Cocl2-N-Acetylcysteine In Rats, Li Wang, Mihai Gagea, Karen S. Martirosyan, Mary Johansen, Timothy Madden, Lisa Norberg, Kirk S. Culotta, Steven J. Frank

Physics & Astronomy Faculty Publications

C4 (cobalt dichloride-N-acetylcysteine [1% CoCl 2 :2% NAC]) is a novel magnetic resonance imaging contrast marker that facilitates visualization of implanted radioactive seeds in cancer brachytherapy. We evaluated the toxicity of C4. Rats were assigned to control (0% CoCl 2 :NAC), low-dose (0.1% CoCl 2 :2% NAC), reference-dose (C4), and high-dose (10% CoCl 2 :2% NAC) groups. Agent was injected into the left quadriceps femoris muscle of the rats. Endpoints were organ and body weights, hematology, and serum chemistry and histopathologic changes of tissues at 48 hours and 28 and 63 days after dosing. Student's t tests were used. No …

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The National Wildlife Strike Database: A Scientific Foundation To Enhance Aviation Safety, Richard A. Dolbeer, Michael J. Begier, John R. Weller Jan 2018

The National Wildlife Strike Database: A Scientific Foundation To Enhance Aviation Safety, Richard A. Dolbeer, Michael J. Begier, John R. Weller

United States Department of Agriculture Wildlife Services: Staff Publications

The U.S. Federal Aviation Administration's (FAA) National Wildlife Strike Database (NWSD) documents reports of civil aircraft collisions with wildlife in USA. The NWSD has been managed by the Wildlife Services Program of the U.S. Department of Agriculture through an interagency agreement since its inception. Although the NWSD includes about 170,000 reports of civil aircraft collisions with wildlife (97% birds) from 1990-2015 (14,000 in 2015), the overriding focus has been the quality control of data entered for over 90 variables ranging from species and numbers of wildlife struck, location and time of day, phase and height of flight, aircraft type, components …

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To Live And Fly In La: Using Bird Strike And Management Program Information To Improve Safety At Airports In The Los Angeles Basin, Todd J. Pitlik, Elizabeth Hermann, Eric Peralta, Brian E. Washburn Jan 2018

To Live And Fly In La: Using Bird Strike And Management Program Information To Improve Safety At Airports In The Los Angeles Basin, Todd J. Pitlik, Elizabeth Hermann, Eric Peralta, Brian E. Washburn

United States Department of Agriculture Wildlife Services: Staff Publications

Wildlife-aircraft collisions (wildlife strikes) pose a serious safety risk to aircraft. Wildlife strikes can be evaluated at different levels, include efforts to examine these problems at the national, regional, or state level, or for an individual airport. Similarly, wildlife strikes involving individual wildlife species or guilds can be examined at varying scales. Although wildlife strike analyses at the national, regional, or species/guild level are valuable, airport-specific analyses are essential for the effective implementation and evaluation of integrated wildlife damage management programs as these actions are conducted at the airport level. The species that present hazards to safe aircraft operations varies …

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Chesapeake Bay Nutria Eradication Project: 2017 Update, Margaret Pepper, Kevin Sullivan, Robert Colona, Jonathan Mcknight Jan 2018

Chesapeake Bay Nutria Eradication Project: 2017 Update, Margaret Pepper, Kevin Sullivan, Robert Colona, Jonathan Mcknight

United States Department of Agriculture Wildlife Services: Staff Publications

Nutria, a semi-aquatic, South American rodent, was introduced to Maryland during the early 1940s. Originally brought to the area for fur farms, the market never established and animals were released or escaped. Nutria thrived, destroying coastal wetlands which resulted in negative environmental and economic impacts to the Chesapeake Bay region. To preserve and protect valuable wetland resources, the Chesapeake Bay Nutria Eradication Project (CBNEP) was established in 2002 through a partnership between the United States Fish and Wildlife Service, the United States Department of Agriculture’s Wildlife Services, Maryland Department of Natural Resources, and many state agencies and non-governmental organizations. Since …

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Anticoagulant Rodenticide Residues In Game Animals In California, Stella C. Mcmillin, Robert H. Poppenga, Shannon C. Chandler, Deana L. Clifford Jan 2018

Anticoagulant Rodenticide Residues In Game Animals In California, Stella C. Mcmillin, Robert H. Poppenga, Shannon C. Chandler, Deana L. Clifford

United States Department of Agriculture Wildlife Services: Staff Publications

Anticoagulant rodenticides (ARs) are used to control rodents around homes, buildings, and in agriculture. They have been found widely in predatory and scavenging wildlife as a result of secondary exposure and less commonly in herbivores and omnivores from primary exposure. While predators and scavengers have been monitored for AR exposure, very little information is available about AR residues in edible muscle tissue of game animals. Game animals may be exposed to ARs through direct consumption of bait, ingestion of contaminated food or vegetation, or consumption of contaminated prey items. Carcasses of three species of game animals (black bear, wild pigs, …

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Environmental And Genetic Factors Affecting Antibiotic Resistance Of Extended Spectrum Î?-Lactamase Bacteria From The Rio Grande River In El Paso, Tx And Cd. Juarez, Mexico, Maria D. Fuentes Jan 2018

Environmental And Genetic Factors Affecting Antibiotic Resistance Of Extended Spectrum Î?-Lactamase Bacteria From The Rio Grande River In El Paso, Tx And Cd. Juarez, Mexico, Maria D. Fuentes

Open Access Theses & Dissertations

Background: The Rio Grande River provides a major source of potable and agricultural water for the population of the Texas/Mexico border region. Cattle farming and ranching are the most prevalent activities, which may contribute to the microbial burden of pharmaceuticals into our state's water resources. Antibiotics, presumably released into the environment by discharges originating from waste-water treatment plants, septic disposal systems, animal feeding operations and urban runoff have a definite impact on the ecosystem and may contribute to an increase in antibiotic resistance. We hypothesized that waters of the Rio Grande River contained Multi Drug Resistant Organisms (MDRO) and mobile …

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Integrated Immunoassays On Paper/Polymer Hybrid Microfluidic Devices For Low-Cost Detection Of Disease Biomarkers, Sanjay Sharma Timilsina Jan 2018

Integrated Immunoassays On Paper/Polymer Hybrid Microfluidic Devices For Low-Cost Detection Of Disease Biomarkers, Sanjay Sharma Timilsina

Open Access Theses & Dissertations

Infectious diseases and cancers have been the major cause of global death and disability causing a significant impact on global health and economies. Enzyme-linked immunosorbent assay (ELISA) is one of the most widely used laboratory diagnostic methods for infectious diseases and cancer. ELISA detects proteins based on their binding to immobilized antibodies or antigen. Even though most ELISAs performed today in 96-well plates are well suited for high throughput assays, performing ELISA in low-resource settings is limited by several factors, such as long incubation time, large volumes of precious reagents, and well-equipped laboratories. Herein, we have developed multiple simple, miniaturized …

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