Digital Commons Network^™

Determining Drug Dosage Using Calculus, Rajendra Dahal, Keith Bullard

Journal of the South Carolina Academy of Science

For most drugs, there is a concentration below for which the drug is ineffective and a concentration above for which the drug is dangerous. In this paper, we will study how the dosage and dosing intervals can be modified to ensure a safe, yet efficient level of the drug in the bloodstream using calculus. In particular, we will study the concentration of a drug over time and its dosing schedule.

Examination Of Oncogenic Effects Of Environmental Pollutants, Andrew Ackerman, Matthew Behling, Brock Earley, Janay Vacharasin

Journal of the South Carolina Academy of Science

Chemical byproducts produced by surrounding industrial complexes have polluted the local estuaries of Georgetown, South Carolina for several decades¹. Previous studies completed by the EPA and SCDNR showed that the estuaries contained carcinogenic pollutants released from the local manufacturing plants¹. One of the mentioned pollutants was dioxins which are produced during the paper bleaching process². Dioxins are highly toxic compounds that have various carcinogenic effects on the organisms that inhabit the area. These previous studies were conducted over thirty years ago. Therefore, a current study to determine if chemical byproducts are contaminating local estuaries …

Pulling Up Stakes: Migrating Digital Collections From Contentdm To Digital Commons, Adam C. Northam

Velma K. Waters Library Faculty Publications

No abstract provided.

Development And Validation Of A Chemistry Laboratory Safety Knowledge, Attitudes, Practices, And Mindset Questionnaire, Claudine Garcia, Genejane Adarlo, Anna Carissa San Esteban, Armando M. Guidote

Health Sciences Faculty Publications

Accidents in chemistry laboratories can be prevented by fostering a safety culture - the institution’s knowledge, attitudes, practices (KAP), and mindset regarding laboratory safety. To effectively promote a safety culture, robust tools are essential for evaluating safety KAP and mindset. Hence, this study developed and validated a questionnaire that can rapidly measure laboratory safety KAP and mindset to guide targeted interventions aimed at enhancing the safety culture in chemistry laboratories. The study was drawn from existing validated questionnaires in constructing a tool comprising 40 items that can measure the safety KAP and mindset in chemistry laboratories. Using a cross-sectional design, …

Cucumber Mosaic Virus And Its Management In Narrow Leafed Lupins, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Cucumber mosaic virus (CMV) is a seed- and aphid-borne virus that infects narrow-leafed lupins. Western Australian (WA) grainbelt regions most at risk are the high rainfall zones of the northern and central agricultural region and the south coastal region.

The principal infection source for lupin crops is sowing infected lupin seed.

Microfiltration Membrane Pore Functionalization With Primary And Quaternary Amines For Pfas Remediation: Capture, Regeneration, And Reuse, Sam Thompson, Angela Gutierrez, Jennifer Bukowski, Dibakar Bhattacharyya

UK CARES Faculty Publications

The widespread production and use of multi-fluorinated carbon-based substances for a variety of purposes has contributed to the contamination of the global water supply in recent decades. Conventional wastewater treatment can reduce contaminants to acceptable levels, but the concen- trated retentate stream is still a burden to the environment. A selective anion-exchange membrane capable of capture and controlled release could further concentrate necessary contaminants, mak- ing their eventual degradation or long-term storage easier. To this end, commercial microfiltration membranes were modified using pore functionalization to incorporate an anion-exchange moiety within the membrane matrix. This functionalization was performed with primary and …

Planetary Health Learning Objectives: Foundational Knowledge For Global Health Education In An Era Of Climate Change, Kathryn H. Jacobsen, Caryl E. Waggett, Pamela Berenbaum, Brett R. Bayles, Gail L. Carlson, René English, Carlos A Faerron Guzmán, Meredith L. Gartin, Liz Grant, Thomas L. Henshaw, Lora L. Iannotti, Philip J. Landrigan, Nina Lansbury, Hao Li, Maureen Y. Lichtveld, Ketrell Mcwhorter, Jessica E. Rettig, Cecilia J. Sorensen, Eric J. Wetzel, Dawn Michele Whitehead, Peter J. Winch, Keith Martin

Earth and Environmental Sciences Faculty Publications

Planetary health is an emerging field that emphasises that humans depend on a healthy Earth for survival and, conversely, that the sustainability of Earth systems is dependent on human behaviours. In response to member demands for resources to support teaching and learning related to planetary health, the Consortium of Universities for Global Health (CUGH) convened a working group to develop a set of planetary health learning objectives (PHLOs) that would complement the existing ten CUGH global health learning objectives. The eight PHLOs feature Earth system changes, planetary boundaries, and climate change science; ecological systems and One Health; human health outcomes; …

Open Groundwater Drains In Wa, Department Of Primary Industries And Regional Development, Western Australia

Natural resources factsheets

Open groundwater drains are excavated channels with sloping floors and sides and open levees, designed to intercept and drain surface (usually fresh) and groundwater (usually saline in WA) from agricultural land. These drains are most effective where the channel is dug below a water table in soils that allow good lateral drainage.

DPIRD recommends leveed groundwater drains in most cases. These should form part of a whole farm and whole catchment integrated water and salinity management program. Information on this page is a guide only. It is highly recommended that landholders considering the construction of open drains seek expert advice …

Contemplating Existence: Ai And The Meaning Of Life, Emily Barnes, James Hutson

Faculty Scholarship

This article explores the intersection of artificial intelligence (AI) with existential philosophy, examining how AI technologies influence human conceptualizations of purpose and meaning. Despite rapid advancements in AI, the domain's implications for existential thought remain underexplored. By integrating interdisciplinary perspectives from psychology, philosophy, and AI ethics, this study elucidates how AI can shape, challenge, or enhance our understanding of life's purpose. It investigates theoretical frameworks and practical implementations of AI engaging in existential questions, analyzing both the capabilities and limitations of AI systems such as ChatGPT in simulating human existential thought. The ethical implications of AI's role in existential inquiries …

Pasture Data Reconciliation Of The South West Agricultural Zone Of Western Australia September 2024, Tafesse Estifanos, Amir Abadi Ghadim, Paul Mattingley, Kate Pritchett, Tony Della Bosca

Animal production and livestock published reports

Western Australia’s (WA) agricultural land use system features extensive pasture land vital for grazing sheep and cattle. Most pastures in the south west of Western Australia consist of annual species that grow during the cool, wet winters of the Mediterranean climate and senesce in the warm to hot, dry summers. Understanding the spatial distribution of pasture areas within the context of mixed farming is essential for developing effective land management strategies to enhance livestock production and profitability through balanced pasture supply and demand.

This report focuses on reconciling pasture area data for the south-west of Western Australia’s agricultural zone across …

Septoria Avenae Blotch And Its Management In Oats, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Septoria avenae blotch (Phaeosphaeria avenaria f.sp. avenaria) is a stubble borne fungal disease of oats and is the most common oat disease in Western Australia and occurs throughout the cereal growing areas.It is host specific, meaning it only affects oats.

This page summarises the symptoms, factors favouring disease risk and spread, yield and quality losses, and management strategies for the disease

Coastal Flood Risk In The Context Of Climate Change And Urbanization In Northeastern South Carolina, Hongyuan Zhang

Electronic Theses and Dissertations

Researchers and the public now widely recognize the seriousness of coastal flood risks. Various changes in natural processes, such as altered rainfall patterns, increased tropical cyclone intensities, and sea-level rise, are consequences of global warming induced by heightened greenhouse gas concentrations. To comprehensively understand coastal compound flooding, it is crucial to consider multiple processes and their interactions. Moreover, the growth of coastal cities and the concentration of people and assets in these areas make them increasingly vulnerable to flooding events. Accurately estimating the future flood risks faced by coastal communities necessitates addressing the compounding effects on coastal flood risk, taking …

Highly Toxic Aβ Begets More Aβ, Merc M. Kemeh, Noel Lazo

Chemistry

No abstract provided.

Coal Ash Triggers An Elevated Temperature Landfill Development: Lessons From The Bristol Virginia Solid Waste Landfill Neighboring Community, Reagan Patton Witt, Marcelo I. Guzman

UK CARES Faculty Publications

Landfills for disposing of solid waste are designed, located, managed, and monitored facili- ties expected to comply with government regulations to prevent contamination of the surrounding environment. After the average life expectancy of a typical landfill (30 to 50 years), a large investment in the construction, operation, final closure, and 30-year monitoring of a new site is needed. In this case study, we provide a holistic explanation of the unexpected development of elevated temperature landfills (ETLFs), such as that in the city of Bristol (United States) on the border of the states of Virginia and Tennessee, including the initial role …

Investigation Of Temperature, Solution Strength, And Applied Stress Effects On Cation Exchange Processes In Different Geosynthetic Clay Liner Products, Kendra Fuller

Master's Theses

An extensive laboratory test program was conducted to analyze and compare the cation exchange processes in three different varieties of sodium bentonite (Na-B) geosynthetic clay liners (GCLs) over increased conditioning durations up to 32 days and investigate the effects of temperature, solution strength, and applied stress. The goal of this test program was to establish whether the variables of temperature, solution strength, and applied stress improved or degraded the engineering properties of GCLs in laboratory testing and municipal solid waste (MSW) landfill applications. The GCLs were conditioned in liquids of increasing ionic strength, using deionized water and 2, 50, and …

History & Evolution Of Plastic Mulching Technology: An Ethnography Of California Strawberry Plasticulture, Kalea Conrad

Master's Theses

This ethnography draws on key informant interviews and participant observation to produce a case study about plastic mulching as an important industry standard in specialty crop production. It documents the historic adoption and present role of plastic mulching technology in California strawberry production and addresses the characteristics of commercial standard management that inhibit the adoption of alternative mulching practices. It complements extensive research on strawberry pathology and fumigation, breeding innovations, fertilizer and pesticide treatments, and maximization of yields to incorporate participants’ lived experiences and knowledge of mulch origins, the technology adoption process, mulch benefits and drawbacks, the state of agricultural …

An Artificial Intelligence Report Card For Judicial Review, Zoe E. Niesel

Michigan Journal of Environmental & Administrative Law

The rapid advancement of technology, including artificial intelligence (AI), is creating new challenges for judicial review under the Administrative Procedure Act (APA). In late 2023, federal administrative agencies publicly disclosed over 700 use cases of AI that employ sophisticated techniques like machine learning and natural language processing. While the APA's flexible judicial review framework certainly allows agencies to utilize new technologies, the APA also requires explainability of agency decisions; thus, agencies must be able to articulate the reasoning and methodology behind AI-enabled decisions for the purpose of judicial review. This Article examines APA judicial review as it applies to agency …

Incorporating Solvation Thermodynamic Mapping In Computer-Aided Drug Design, Yeonji Ji

Dissertations, Theses, and Capstone Projects

Advancements in computational techniques have revolutionized structure-based drug design, substantially improving the efficiency and effectiveness of the drug discovery process by reducing time, costs, and labor requirements. These advancements include various methods, such as investigating small molecule ligands binding to proteins, exploring alternative protein conformations, and solvation mapping on the protein surfaces. Among these methods, understanding the correlation between protein-ligand binding and the role of solvation is important.

A fundamental concept in protein-ligand binding is shape and electrostatic complementarity, which is complicated by the inherent flexibility of proteins. In the absence of small molecule ligands, proteins are complementary to surface …

Appendix D Comparison Of Historical Coc Results To Groundwater Remedial Goals, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final Bpsou Insufficiently Reclaimed Sites Belle Of Butte (Bres No. 8 & Ur-39) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2024 Draft Blacktail Creek Remediation And Contaminated Groundwater Hydraulic Control Site Pre-Design Investigation Work Plan, Stantec Consulting Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Reveal: A Technical Study And Conservation Treatment Of An Overpaint Portrait, Camille Ferrer

Art Conservation Master's Projects

A severely damaged 19th-century oil painting depicting a portrait of a woman was treated at Patricia H. and E. Garman Art Conservation Department. A typed letter provided by the owner mentioned that it has been previously restored yet returned with unsatisfactory results. After further examination, the painting appeared to have been previously treated multiple times by different people. There was overpaint distinctly present on the face and later discovered to be present overall. The full state of condition of the painting was initially unknown due to the sum of the surface being overpainted. However, there were evidence of paint loss …

Reclaiming Healing Spaces: A Phenomenological Study On The Transformative Power Of Outdoor Therapy From The Lived Experiences Of Black Clinicians Working With Black Clients, Lynn Murphy

Dissertations

This phenomenological study involved assessing the experiences of Black therapists who engaged Black clients in outdoor therapeutic contexts. The study was founded on the existing literature that shows the quality of the therapeutic relationship is pivotal for client retention and the Western standards that have historically favored treatment within indoor environments. To contextualize this research, a comprehensive literature review was commenced, covering topics such as the decolonization of therapy, the historical and present-day relationship between Blacks and the outdoors in the United States, sedentary lifestyles, the psychological benefits of time spent in nature, various types of outdoor therapy, and the …

Two-Way Coupling Of The National Water Model (Nwm) And Semi-Implicit Cross-Scale Hydroscience Integrated System Model (Schism) For Enhanced Coastal Discharge Predictions, Hongyuan Zhang, Dongliang Shen, Shaowu Bao, Pietrafesa Len

Marine Science

This study addresses the limitations of and the common challenges faced by one-dimensional river-routing methods in hydrological models, including the National Water Model (NWM), in accurately representing coastal regions. We developed a two-way coupling between the NWM and the Semi-implicit Cross-scale Hydroscience Integrated System Model (SCHISM). The approach demonstrated improvements in modeling coastal river dynamics, particularly during extreme events like Hurricane Matthew. The coupled model successfully captured tidal influences, storm surge effects, and complex river–river interactions that the standalone NWM missed. The approach revealed more accurate representations of peak discharge timing and magnitude as well as water storage and release …

Two-Dimensional Quantum Material Identification Via Self-Attention And Soft-Labeling In Deep Learning, Xuan Bac Nguyen, Apoorva Bisht, Benjamin Thompson, Hugh O.H. Churchill, Khoa Luu, Samee U. Khan

Electrical Engineering and Computer Science Faculty Publications and Presentations

Detecting two-dimensional (2D) materials in silicon chips presents a significant challenge in the field of quantum machines due to the difficulty of data collection. Specifically, among thousands of flakes, not all flakes are useful or well-annotated, resulting in noisy and hard samples within the dataset, which challenges the deep neural network (DNN) to learn. To address this problem, we propose a novel method for identifying quantum 2D flakes even when there is a high rate of missing annotations in the input images. In particular, we first propose a new mechanism for automatically detecting false negative flakes that are missing annotations. …

A Staged Approach Using Machine Learning And Uncertainty Quantification To Predict The Risk Of Hip Fracture, Anjum Shaik, Kristoffer A. Larsen, Nancy E. Lane, Chen Zhao, Kuan Jui Su, Joyce H. Keyak, Qing Tian, Qiuying Sha, Hui Shen, Hong Wen Deng, Weihua Zhou

Michigan Tech Publications

Hip fractures present a significant healthcare challenge, especially within aging populations, where they are often caused by falls. These fractures lead to substantial morbidity and mortality, emphasizing the need for timely surgical intervention. Despite advancements in medical care, hip fractures impose a significant burden on individuals and healthcare systems. This paper focuses on the prediction of hip fracture risk in older and middle-aged adults, where falls and compromised bone quality are predominant factors. The study cohort included 547 patients, with 94 experiencing hip fracture. To assess the risk of hip fracture, clinical variables and clinical variables combined with hip DXA …

Midwest Data Librarian Symposium: A Model For Regional Communities, Amy Koshoffer, Kelsey Badger, Kristen Adams, Ana Munandar

Library Articles and Research

The Midwest Data Librarian Symposium (MDLS) is an annual unconference covering data and data librarianship. The symposium aims to provide a venue for librarians and others interested in the topics to network, discuss issues related to research data management, and learn from each other. While most of the attendees are from the Midwest area, the symposium is open to all.

MDLS is a community-led effort and has no governing body. In this article, we share our experiences in contributing to MDLS, including the recent MDLS 2023. Coming up on its tenth year in 2024, we believe MDLS offers a valuable …

Willingness To Pay And Market Potential For Biowrap: An Economic Study Of A New Biodegradable Mulch Product In Home Gardening, Gengchen Cai

Department of Agricultural Economics: Dissertations, Theses, and Student Research

This study explores the market potential of BioWRAP, a biodegradable sprayable weed suppression product, by assessing the willingness to pay (WTP) among American home gardeners. Traditional plastic mulch offers significant agronomic benefits but poses considerable environmental challenges, making BioWRAP a promising alternative due to its similar benefits and reduced environmental impact. Using a double-bounded contingent valuation method, we analyze the WTP for BioWRAP among different demographic groups and gardening practices. Our findings indicate that the highest WTP for BioWRAP is among home gardeners who currently use chemical sprays for weed suppression, followed by those using physical barriers, with the lowest …

Enhancing Multi-Agent System Testing With Diversity-Guided Exploration And Adaptive Critical State Exploitation, Xuyan Ma, Yawen Wang, Junjie Wang, Xiaofei Xie

Research Collection School Of Computing and Information Systems

Multi-agent systems (MASs) have achieved remarkable success in multi-robot control, intelligent transportation, and multiplayer games, etc. Thorough testing for MAS is urgently needed to ensure its robustness in the face of constantly changing and unexpected scenarios. Existing methods mainly focus on single-agent system testing and cannot be directly applied to MAS testing due to the complexity of MAS. To our best knowledge, there are fewer studies on MAS testing. While several studies have focused on adversarial attacks on MASs, they primarily target failure detection from an attack perspective, i.e., discovering failure scenarios, while ignoring the diversity of scenarios. In this …

Self-Supervised Spatial-Temporal Normality Learning For Time Series Anomaly Detection, Yutong Chen, Hongzuo Xu, Guansong Pang, Hezhe Qiao, Yuan Zhou, Mingsheng Shang

Research Collection School Of Computing and Information Systems

Time Series Anomaly Detection (TSAD) finds widespread applications across various domains such as financial markets, industrial production, and healthcare. Its primary objective is to learn the normal patterns of time series data, thereby identifying deviations in test samples. Most existing TSAD methods focus on modeling data from the temporal dimension, while ignoring the semantic information in the spatial dimension. To address this issue, we introduce a novel approach, called Spatial-Temporal Normality learning (STEN). STEN is composed of a sequence Order prediction-based Temporal Normality learning (OTN) module that captures the temporal correlations within sequences, and a Distance prediction-based Spatial Normality learning …