Digital Commons Network^™

Ca-Vqvae: Cortical Folding Aware Numerical Representation Of White-Matter Structure, Yanjun Lyu, Jing Zhang, Lu Zhang, Tong Chen, Xiaowei Yu, Minheng Chen, Yan Zhuang, Chao Cao, Tianming Liu, Dajiang Zhu

Computer Science Faculty Research & Creative Works

White matter (WM) serves as a fundamental component of the brain providing essential structural support and facilitating the brain cognitive processes. Thus, an accurate and efficient description of the brain's white matter structure is essential for understanding brain function connectivity and development. In this work we used the deep model to combine the information of the WM fiber bundle shape and its related cortical folding patterns together representing the WM fiber bundle from diffusion MRI tractography into a pre-defined low-dimensional space and generate the numerical representation vector. This cortical-aware vector-quantized variational encoder (CA-VQVAE) framework leverages cortical locations and folding patterns …

Echopulse: Ecg Controlled Echocardiograms Video Generation, Yiwei Li, Sekeun Kim, Zihao Wu, Hanqi Jiang, Yi Pan, Pengfei Jin, Sifan Song, Yucheng Shi, Xiaowei Yu, Tianze Yang, Tianming Liu, Quanzheng Li, Xiang Li

Computer Science Faculty Research & Creative Works

Echocardiography (ECHO) is essential for cardiac assessments, but its video quality and interpretation heavily rely on manual expertise, leading to inconsistent results from clinical and portable devices. ECHO video generation offers a solution by improving automated monitoring through synthetic data and generating high-quality videos from routine health data. However, existing models often face high computational costs, slow inference, and rely on complex conditional prompts that require experts' annotations. To address these challenges, we propose ECHOPulse, an ECG-conditioned ECHO video generation model. ECHOPulse introduces two key advancements: (1) it accelerates ECHO video generation by leveraging VQ-VAE tokenization and masked visual token …

Spatial Analysis Of American Chestnut (Castanea Dentata) Distribution And Ecology In Kentucky’S Federal Lands, Jacob Raymond Pease

Murray State Theses and Dissertations

Anthropogenic factors have been the cause of the decline of tree species across the globe. From unsustainable logging and development to disease and improper management, threats to forests have taken their toll. The American chestnut (Castanea dentata) was once an integral basal tree species in Appalachian forests, but chestnut blight drove the species to functional extinction by the mid-1900s. The recent creation of genetically modified chestnuts gives hope for future restoration of the species throughout its historical range. Despite blight resistance, effective restoration will require optimal site selection for finding and planting chestnuts, which will maximize limited resources. …

Approaches To The Synthesis Of Highly Substituted Arenes, Kh Tanvir Ahmed

Graduate Theses, Dissertations, and Problem Reports (ETD)

While benzene rings and their derivatives are among the most frequently encountered ring systems in natural products, pharmaceuticals, agrochemicals, dyes, and functional materials, polysubstituted arenes are relatively scarce. The analysis of FDA-approved small molecules provides valuable insights into the characteristics of successful drugs while also highlighting gaps in the availability of synthetic methods capable of efficiently accessing diverse substitution patterns on aromatic rings. Highly substituted arenes are typically synthesized through sequential modification of a pre-existing benzene core; however, this stepwise approach becomes increasingly challenging with each additional substitution. An alternative strategy involves the direct construction of benzene rings via annulation …

Photocarrier Dynamics In Dielectric And Metal-Dielectric Nanocatalysts In Ambient And Operando Conditions, Sunil Gyawali

Graduate Theses, Dissertations, and Problem Reports (ETD)

Photocatalysis, a promising method for solar-to-chemical energy conversion, relies on sunlight to generate excited charge carriers in catalysts with sufficient lifetimes and mobilities to drive photoreactions. Thin-film semiconductors are essential for reducing charge recombination and enhancing mobility but suffer from a low surface-to-volume ratio problems, resulting in a reduced absorption coefficient and limiting solar-energy-conversion efficiency. Nanostructures address these limitations by enhancing light absorption and surface reactivity. However, efficient photocatalysis also requires that the semiconductor’s band edges align with the redox potential of the desired photoreaction, limiting light absorption to just some of the whole solar spectrum. In hybrid and composite …

A Spatial Analysis Of Carbon Sequestration On Reclaimed Mine Lands, Jacob Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study evaluates the carbon sequestration potential of C₄ grasses, switchgrass (Panicum virgatum) and miscanthus (Miscanthus × giganteus), on mine-impacted lands in West Virginia. This work addresses the urgent need for scalable, nature-based solutions to reclaim degraded lands and meet global climate mitigation targets. Conducted on a 160-hectare (ha) reclaimed mine land (RML) near Alton, the research assessed soil organic carbon (SOC) and root zone biomass organic carbon (BOC) accumulation over a single growing season. By integrating study site field sampling data, laboratory analysis, and statewide and regional geospatial modeling, the study aimed to determine the feasibility of repurposing mine …

Clear Speech Intervention In Parkinson’S Disease: A Single Case Design Examining Acoustic And Aerodynamic Outcomes Following A Structured Protocol, Zachariah Jordan Backus

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Clear Speech Intervention in Parkinson’s Disease: A Single Case Design Examining Acoustic and Aerodynamic Outcomes Following a Structured Protocol

Zachariah Backus

Purpose:

Parkinson Disease (PD) is a neuro-progressive movement disorder that impacts all movement of the body, including speech production. Ninety percent of individuals living with PD will experience hypokinetic dysarthria, a motor speech disorder, during the progression of their disease. Clear speech instruction is a treatment strategy used to increase motor speech outcomes in those with PD. Studies have shown positive changes in articulation, prosody, voice, and listener perception measures in those with PD after clear speech instruction …

Do Dung Beetles Sink Or Swim: Exploring Dung Beetle Response To Precipitation, Lauren T. Cheshire

Graduate Theses, Dissertations, and Problem Reports (ETD)

Global climate change constitutes a major threat to biodiversity and ecosystem services of many taxa. The Mid-Atlantic region of the US is expecting to see an increase in extreme precipitation events and flooding. Dung beetles (Scarabaeinae) can tunnel below the soil surface allowing for water to dissipate into the soil rather than sit on the surface and add to flooding conditions. They also can decrease methane emission by burying dung and reduce outbreaks of pests that prefer the moist environment of dung. They contribute roughly $380 million in ecosystem services annually in the United States, yet their services may be …

Forensic Characterization And Comparison Of Modern Nail Polish Products By Their Physical Features And Chemical Composition, Madison Meredith Lindung

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nail polish can serve as valuable evidence in forensic investigations as it is often found on the hands and feet of individuals. Nail polish can break off and transfer easily during self-defense actions or forceful contact, such as in cases of kidnapping, sexual assault, or homicide. These residues can provide clues about who was at the scene, as well as where, when, and how the event evolved. However, compared to other types of paints commonly analyzed in forensic laboratories, limited forensic research has been conducted on the chemical composition and discrimination capabilities of popular nail products. The lack of information …

New Psychoactive Substances Detected In Wastewater Samples Collected Along The Interstate Highway Rest Areas In Kentucky, Durga Prasad Kodati

Murray State Theses and Dissertations

The rapid emergence and proliferation of new psychoactive substances (NPS) pose significant challenges to public health and law enforcement. The potential for abuse and toxicity of these substances, which are intended to mimic the effects of controlled drugs, has been raising concerns as these compounds are designed to evade being regulated. There are traditional methods of tracking NPS, such as seizures and forensic toxicology, but they are delayed and seldom effective because these substances continue to evolve rapidly. Wastewater-based epidemiology (WBE) has emerged as a promising tool for real-time surveillance of drug consumption. The primary objective of this research was …

Modelling The Impacts Of Recreational Catch-And-Release Variability On Fish Stock Dynamics, Brett Crisafulli

Theses: Doctorates and Masters

Recreational fisheries often lack sufficient data for robust stock assessments, and post-release mortality (PRM) of discarded fish, particularly demersal species, poses a significant threat to sustainability. Because demersal fish often experience higher PRM (often due to barotrauma and stress), the substantial global interest in their recreational fisheries (e.g., Australia, Gulf of Mexico, Western Baltic Sea) raises conservation concerns. This study employs three distinct modelling approaches, applied to four reef-dwelling demersal species, to support effective recreational fisheries management by addressing data uncertainty, unintended consequences of management changes, and PRM effects. Specifically, this thesis (1) evaluates variability in average weights of recreationally-caught …

Identifying The Impacts Of Land Use/Land Cover Changes On Ecosystem Services From A Geospatial Perspective In Albany County, Kyaw Khaung Thant Zin

Electronic Theses & Dissertations (2024 - present)

Ecosystem services encompass the broad array of direct and indirect advantages that people derive from nature and its ecosystems. Considering accelerating environmental change and degradation, recognizing the importance of these services is more crucial than ever, as they illustrate the many ways in which healthy ecosystems sustain human life. However, these services are diminishing at a rapid and unprecedented rate, raising global concern over both the transformations taking place and their root causes. Among the leading threats, land-use change stands out as a particularly significant one, influenced by a variety of driving factors. Albany County, New York, characterized by its …

Comparison Of Methane Emission Quantification Methods At Landfills In New York State, Alexandra M. Catena

Electronic Theses & Dissertations (2024 - present)

Greenhouse gas (GHG) emission increases are a consequence of global population rise and economic growth. It is well known that carbon dioxide is the dominant GHG by mass, but methane has received increasing attention recently due to its high warming potential and relatively short lifetime of about a decade. Methane has several different types of both natural and anthropogenic sources including wetlands, waste management, energy, agriculture and farming, and wildfires, which makes tracking and reducing methane emissions a complex problem. The emission rates of each of these sources are highly uncertain due to differing emission estimation methods, which can be …

Photoswitchable Inhibitors Of Eaat3, Karly Suhr

Electronic Theses & Dissertations (2024 - present)

Azobenzene is a photoswitchable molecule known for its high conversion yield and repeatability. The inclusion of an azobenzene moiety with a known inhibitor of your target of interest allows for greater study of function as well as potential therapies. Three derivatives were designed from azobenzene and known inhibitor of EAATs, TBOA, to synthesize photoswitchable inhibitors of EAATs. Further investigation into the function of EAATs and development of a specific inhibitor for EAAT3, an important glutamate transporter in the brain required for proper function, can then be conducted. Photoisomerization studies on the derivatives were conducted using UV/vis spectroscopy and NMR spectroscopy. …

Essays On Technological Change And Scientific Research, Max Mayca

Electronic Theses & Dissertations (2024 - present)

The primary objective of economic science has long been to understand and promote growth, as it contributes to a more prosperous civilization and improves individual well-being. The core drivers of growth—capital accumulation, human capital development, and technological progress—are well-established. While capital deepening enables scaling of production, and human capital enhances labor productivity, technological and scientific advancements remain the most critical, as they continually redefine the efficiency frontier. Given this centrality, it is essential to understand how technological progress affects labor markets, how research resources should be allocated, and how technology relates to human capital formation.

The first part of this …

Analysis Of Cytokine Data In A Case-Control Study Of Me/Cfs, Navya Amaratunga

Electronic Theses & Dissertations (2024 - present)

This study investigated the role of cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating multi-system disease with unknown etiology. Using data from a case-control study (60 cases, 61 controls) previously collected by Dr. Roxana Moslehi’s lab, serum levels of 48 cytokines were analyzed. Statistical analyses, including T-tests, Wilcoxon Rank Sum tests, and logistic regression (unadjusted and adjusted for medication use), were performed to identify differences between cases and controls.

Results revealed a statistically significant difference in mean Fractalkine levels between cases and controls (p=0.031). Borderline significant differences were also observed for IL-6 (p=0.046) and MIP-1α (p=0.046). Unadjusted logistic regression …

Ai Characterisations And Their Legal Implications, Jerrold Tsin Howe Soh

Research Collection Yong Pung How School Of Law

This chapter examines the difficult legal characterisation problems that artificially intelligent systems raise and explores how different characterisations of artificial intelligence (AI) shape practical legal outcomes. Three reasons are offered for the legal difficulty with characterising AI. First, answers to characterisation problems are inherently subjective and perspective-driven, particularly when the subject is an intangible technological system. Second, AI technology is especially difficult to define since the field typically proceeds on inexact anthropomorphic metaphors. Third, AI characterisation problems raise difficult sub-problems, particularly in determining how autonomous an AI system is. The chapter thus argues that a range of plausible AI characterisations …

Exploring Nitrate Reduction In A Saturated Riparian Buffer Through A Three-Dimensional Reactive Contaminant Transport Model In An Agricultural Area, Mcclean County Central Illinois, Franklin O. Ijigade

Theses and Dissertations

Saturated Riparian Buffers (SRBs) are engineered systems designed to remove nitrate and other pollutants from subsurface agricultural drainage water before it reaches a stream. This study utilizes a high-resolution coupled flow and reactive transport model to explore nitrate reduction and transformation in an SRB in glacial sediment. The influence of material heterogeneity on nitrate reduction and the effectiveness of the SRB was investigated. The study was conducted in an SRB located next to and receiving tile drainage water that ultimately drains into a 3^rd order stream (T3 stream) in central Illinois, USA. A three-dimensional steady groundwater flow model was …

The Development Of A One Pot, Two Reaction Synthetic Preparation Of 1,2,4-Oxadiazole, And Synthesis Of Ataluren, A Novel Drug In The Fight Against Duchenne Muscular Dystrophy. Efforts Towards The Synthesis Of A Potential Protease Inhibitor Against The Main Protease (3clpro) Of Covid-19, Austin J. Carter

Theses and Dissertations

1,2,4-Oxadiazoles are five-membered heterocyclic structures first synthesized by Tiemann and Krüger in 1884. Recent discoveries suggest an array of useful biological properties.In preparation of 1,2,4-oxadiazoles, the most prevalent precursors are amidoximes, which can be created via the reaction of nitriles with hydroxylamine hydrochloride and a base. The amidoximes are reacted with an activated carboxylic acid to yield an acylated intermediate. This intermediate can be exposed to a base to cyclize into the 1,2,4-oxadiazole. This thesis describes the efforts in combining these three steps into a unified one-pot synthesis.

Currently, there are a significant number of commercially available FDA approved and …

Asymmetric Synthesis Of The Hiv Protease Inhibitor Tmc-126 And An Anti-Malarial Agent Via A Titanium Tetrachloride Mediated Asymmetric Glycolate Aldol Addition Reaction. Redefining The Curtius Rearrangement Reaction Via Dehomologation Of Carboxylic Acids Bearing Alpha-Leaving Groups, Kweku Amaning Affram

Theses and Dissertations

Acquired Immune Deficiency Syndrome (AIDS) and malaria are two devastating infectious diseases caused by HIV and Plasmodium parasites. AIDS is caused by HIV-1 and HIV-2, transmitted through sexual contact, blood transfusions, needle sharing, and perinatal routes. Malaria, caused by plasmodium parasites through mosquito bites. Today, millions of people around the world have been infected with HIV and malaria and much research has been done to treat it. However, despite advancements in therapeutic options, these diseases remain a significant global health threat, particularly in developing countries due to the emergence of drug-resistant strains for both HIV and malaria complicating eradication efforts. …

Neural Network Algorithm And Analysis For Multi-Label Ecg Data Classification, Akhil Raghava Kalal

Theses and Dissertations

Electrocardiogram (ECG) analysis is a fundamental diagnostic tool in cardiology, providing critical insights into cardiac function that directly impact patient care decisions and treatment outcomes. As healthcare systems face increasing demands, automated ECG interpretation using artificial intelligence offers promising solutions to improve diagnostic accuracy, reduce physicians workload, and enhance early detection of life threatening conditions.

This thesis compares two advanced deep learning architectures, CNN-GRU and Wide and Deep Transformer, for multi-label classification of 12-lead ECG data. Using data from the PhysioNet/Computing in Cardiology Challenge 2020, I evaluated both architectures across 27 different cardiac abnormalities. Results demonstrated that CNN-GRU architecture consistently …

Site-Specific Modification Of Antibodies Utilizing Microbial Transglutaminase For Improved Immunoassay Performance, Emily Beitello

Theses and Dissertations

Immobilization strategies used for fixing antibodies to solid phase surfaces significantly contribute to the antigen capture capacity and influences the performance and sensitivity of immunoassays. Traditional methodologies result in the random orientation and/or the weak attachment of immobilized antibodies. Different formats of immunoassays scope in applicability to many fields of research and everyday use. Improving the efficiency of immobilizing antibodies in immunoassays is a beneficial endeavor to increase assay sensitivity. Here, we investigated the use of enzyme-mediated conjugation of antibodies to facilitate a highly oriented immobilization. Microbial transglutaminase (mTG) catalyzes the covalent bond formation between a plethora of primary amine …

Application Of Floating Wetlands To Improve Urban Stream Quality, Daniel Chukwunonso Chukwudi

Theses and Dissertations

Urban streams, impacted by urbanization, often exhibit degraded water quality due to elevated nutrient levels, a phenomenon known as urban stream syndrome. This study evaluates the effectiveness of a floating wetland (FW) system in reducing nitrate as nitrogen (NO₃-N) and phosphate (PO₄³⁻) concentrations in a side canal of the Chicago River’s North Branch, adjacent to Goose Island, Chicago, IL, from 2018 to 2023. Using a five-year dataset, including new sampling from May to December 2023, the research addresses two questions: (1) Do FWs lower NO₃-N and PO₄³⁻ concentrations in urban streams? and (2) Do FWs exhibit seasonal differences in nutrient …

Technological Development Of In-Cell Nmr: Microfluidic, Metabolomic, And Fluxomic Approaches, Nicholas Sciolino

Electronic Theses & Dissertations (2024 - present)

In the fields of structural biology, metabolomics, and fluxomics, there is a driving, technique-based concern when it comes to high-resolution spectrometry and its marriage to biological and physiological relevance. Sample preparation often involves cellular perturbation, lysate separation schemes, combinations with non-biological reagents, and timeline slack. Conceptually, the farther we get from the cell, the greater the potential disparity between what exists in vivo and our in vitro manipulations. This is particularly true when seeking to collect data on transfected targets of interest, and on sensitive metabolic equilibria that occur on the order of minutes. The question remains: if we are …

Towards Human Explainable Digital Forensics: Generating Human Interpretable Evidence For Semantic Understanding In Manipulated Images And Text, Yuwei Chen

Electronic Theses & Dissertations (2024 - present)

Detecting and characterizing manipulations in digital media continues to pose a significant challenge within the field of digital forensics. Despite notable advancements, the discipline often remains in a reactive stance against emerging threats. Current state-of-the-art methods, typically evaluated within academic settings, fails to mirror the complexities of real-world disinformation scenarios. These methods generally prioritize high performance based on quantitative metrics, yet they demonstrate a considerable dependency on training data and lack adaptability to new novel attack signatures. With the rapid evolution of attack methodologies, the dependency on highly accurate models that do not generalize or adapt well to unseen threats …

A New G Family: Properties, Characterizations, Different Estimation Methods And Port-Var Analysis For U.K. Insurance Claims And U.S. House Prices Data Sets, Ahmad M. Aboalkhair, Gholamhossein Hamedani, Nazar Ali Ahmed, Mohamed Ibrahim, Mohammad A. Zayed, Haitham M. Yousof

Mathematical and Statistical Science Faculty Research and Publications

This paper introduces a new class of probability distributions, termed the generated log exponentiated polynomial (GLEP) family, designed to enhance flexibility in modeling complex real financial data. The proposed family is constructed through a novel cumulative distribution function that combines logarithmic and exponentiated polynomial structures, allowing for rich distributional shapes and tail behaviors. We present comprehensive mathematical properties, including useful series expansions for the density, cumulative, and quantile functions, which facilitate the derivation of moments, generating functions, and order statistics. Characterization results based on the reverse hazard function and conditional expectations are established. The model parameters are estimated using various …

A Systematic Review On Mental Health Chatbots: Trends, Design Principles, Evaluation Methods, And Future Research Agenda, Mohammad Amin Kuhail, Ons Al-Shamaileh, Shahbano Farooq, Hana Shahin, Fatema Abdelzaher, Justin Thomas

All Works

Recent decades have witnessed a rise in the prevalence of common mental health problems coupled with an increasing demand for talk‐based psychological therapies. This has coincided with the rise of mental health chatbots (MHCs), a corollary of which is the use of MHCs, AI‐driven, conversational agents, to provide interactive support, guidance, and therapeutic engagement for persons experiencing mental health challenges. There has been a growing research interest in MHCs, and this study provides a much‐needed systematic review that examines this expanding research literature, identifying themes, trends, and areas worthy of further exploration. This review identified and systematically explored 97 published …

Ecological Resources Of A Heavily Modified And Utilised Temperate Coastal Embayment: Cockburn Sound, Peter J. Mitchell, Daniel E. Yeoh, Kurt N. Krispyn, Claire N. Greenwell, Sorcha Cronin-O’Reilly, Delphine B.H. Chabanne, Glenn A. Hyndes, Danielle Johnston, David V. Fairclough, Claire Wellington, Alan Cottingham, Gary Jackson, Jeffrey V. Norriss, Matias Braccini, Hector Lozano-Montes, Chandra P. Salgado Kent, Erin Clitheroe, Alissa Tate, James W. Penn, Marion Massam, Neil R. Loneragan, James R. Tweedley

Research outputs 2022 to 2026

Coastal environments and their associated biota provide numerous environmental, economic and societal services. Cockburn Sound, a temperate embayment on the lower west coast of Western Australia, is immensely important for the State and adjacent capital city of Perth. However, urbanisation and associated terrestrial and marine development has the potential to threaten this important ecosystem. This study collated published and unpublished data to review the current state of the ecological resources of Cockburn Sound and describe how they have changed over the past century. Post-WWII, the embayment began undergoing pronounced anthropogenic changes that limited oceanic water exchange, increased nutrient load, modified …

Novel Digital Twin Deployment Approaches: Local And Distributed Digital Twin, Shahid Rauf, Fazal Muhammad, Akhtar Badshah, Hisham Alasmary, Muhammad Waqas, Sheng Chen

Research outputs 2022 to 2026

The Digital Twin (DT) technology is considered as a backbone in the Industrial 4.0 revolution as it is playing a vital role in the digitization of various industries. A DT is a virtual representation of a physical entity, thus having the ability to simulate real data generated at physical space to optimize, estimate, control, monitor and forecast states/configurations. Despite enormous benefits, DT technology has several implementation challenges. Although deploying DT on edge or cloud platforms yields a plethora of services, its implementation in both spaces faces certain limitations. These limitations include latency, data communication overload, transmission energy consumption, privacy concerns, …

S-Methyl Cysteine Sulfoxide And Its Potential Role In Human Health: A Scoping Review, Caroline R. Hill, Alex Haoci Liu, Lyn Mccahon, Liezhou Zhong, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

Higher intakes of cruciferous and allium vegetables are associated with a lower risk of cardiometabolic-related outcomes in observational studies. Whilst acknowledging the many healthy compounds within these vegetables, animal studies indicate that some of these beneficial effects may be partially mediated by S-methyl cysteine sulfoxide (SMCSO), a sulfur-rich, non-protein, amino acid found almost exclusively within cruciferous and alliums. This scoping review explores evidence for SMCSO, its potential roles in human health and possible mechanistic action. After systematically searching several databases (EMBASE, MEDLINE, SCOPUS, CINAHL Plus Full Text, Agricultural Science), we identified 21 original research articles meeting our inclusion criteria. These …