Digital Commons Network^™

Survival Predictions From Classification Algorithms – Concepts And Application To Graft And Patient Survival After Kidney Transplantation, Antje Jahn

SAML-25 Workshop on Statistical and Machine Learning

Clinical prediction models are developed to predict long-term patient outcomes following medical interventions. One example motivating this research is the prediction of graft and patient survival after kidney transplantation, using data from the German organ transplantation registry. A practical issue in this context is to deal with incomplete information due to right-censoring, which arises when patients are lost to follow-up or enter the study at different times, resulting in varying durations of observation. This is particularly relevant in the registry data, where follow-up is frequently incomplete or irregular. While traditional survival analysis methods handle censoring by modeling the hazard function, …

Pathology’S Place In Understanding The Bias And Inequalities In Women’S Healthcare, Andrea Heaney, Eugene Hickey, Emma Murphy

SAML-25 Workshop on Statistical and Machine Learning

Women’s healthcare is a complex, multifaceted issue with both historic and implicit biases, along with biological differences between men and women. With the advancement of AI tools in healthcare and the potential for biased data to create biased models, it is vital to consider how women are represented in data. Previously conducted semi-structured semantic interviews with clinicians were analysed via Braun and Clark’s method of thematic analysis. The analysis of these interviews yielded the following themes: Gender Influencing Health, Pregnancy, Social Factors, General Health, Treatment, Training, and Research. These themes highlight that context is key to understanding the biases in …

Impact Of Spatial Diversity And Subject Variability On Wifi-Based Human Activity Recognition, Amany Elkelany, Robert J. Ross, Susan Mckeever

SAML-25 Workshop on Statistical and Machine Learning

In recent years, WiFi-based Human Activity Recognition (HAR) has gained substantial attention due to the ubiquity of WiFi infrastructure and advancements in wireless communication. Unlike camera-based systems that raise privacy concerns or wearable sensors that require user compliance, WiFi-based HAR provides a noninvasive and practical alternative that operates seamlessly with existing infrastructure. WiFi-based HAR leverages fluctuations in wireless signals, particularly Channel State Information (CSI), to passively detect and classify human activities. WiFi-based HAR models often achieve high accuracy in a single environment but suffer significant performance drops when applied to new environments due to variations in spatial settings, human movement, …

Tracking The Kinetics Cellular Glycolysis And Glutaminolysis Pathways Using Vibrational Spectroscopy, Combined With Multivariate Statistical And Machine Learning Approaches For Data Mining, Zohreh Mirveis, Nithin Patil, Hugh Byrne

SAML-25 Workshop on Statistical and Machine Learning

Understanding dynamic metabolic processes within living cells is crucial for gaining insights into cellular function and disease mechanisms. The kinetics of glycolysis and glutaminolysis pathways play significant roles, as alterations in their activity have been linked to various disorders, including cancer and mental health conditions such as bipolar disorder. These pathways therefore hold potential as biomarkers for disease diagnosis and therapy. However, real-time monitoring of their kinetics remains challenging due to the lack of suitable non-invasive techniques. Current gold-standard fluxomics approaches, such as mass spectrometry, are destructive to cells and thus unsuitable for time-resolved studies. In this study, we evaluate …

A Framework For Scalable And Controlled Hallucination Data Collection, Lin Ting Liang

Computer Science Senior Theses

This thesis addresses a key bottleneck in hallucination research: the scarcity and limitations of hallucination benchmark datasets. Existing datasets typically focus on a single type of hallucination and are expensive to produce due to the need for manual prompt creation and annotation. To overcome these challenges, we propose a novel mixture-of-experts (MoE) adversarial framework that actively induces hallucinations. Our framework employs three large language model (LLM) agents that iteratively and adversarially revise prompts to provoke hallucinated responses from a target question-answering model. It automates the generation of both intrinsic hallucinations (logical inconsistencies) and extrinsic hallucinations (inclusion of unverifiable external information). …

Ensemble-Based Binding Free Energy Profiling And Network Analysis Of The Kras Interactions With Darpin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants And Universal Architecture Of Regulatory Hotspots And Allosteric Binding, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

KRAS is a pivotal oncoprotein that regulates cell proliferation and survival through interactions with downstream effectors such as RAF1. Despite significant advances in understanding KRAS biology, the structural and dynamic mechanisms of KRAS allostery remain poorly understood. In this study, we employ microsecond molecular dynamics simulations, mutational scanning, and binding free energy calculations together with dynamic network modeling to dissect how engineered DARPin proteins K27, K55, K13, and K19 engage KRAS through diverse molecular mechanisms ranging from effector mimicry to conformational restriction and allosteric modulation. Mutational scanning across all four DARPin systems identifies a core set of evolutionarily constrained residues …

Spatial Analysis Of La Nana Bayou Watershed To Assess Stream Health, Rylee G. Gabbert

Electronic Theses and Dissertations

The purpose of this study was to evaluate the feasibility of using land cover mapping to identify water quality indicators within a river basin, assessing whether this method provides greater efficiency compared to traditional field-based water quality testing. Land cover mapping has efficiently monitored environmental changes by detecting alterations within specific areas. With the La Nana Bayou Watershed positioned in the heart of Nacogdoches City, an urbanized environment; it is subject to human induced alterations that can negatively affect the natural functionality of its system. When water quality indicators are successfully related to land cover maps, changes within the landscape …

Evaluating Vision Language Model Capabilities For Time Series Interpretation: An Empirical Study With Conversation Duration And Psychological Flourishing Data From The Studentlife Dataset, Jusung Park

Computer Science Senior Theses

This research investigates the capability of Vision Language Models (VLMs), specifically ChatGPT‑4o, to interpret and predict psychological outcomes based on visual representations of time series data. Leveraging conversation duration metrics and psychological flourishing scores from the StudentLife dataset, this study rigorously evaluates the predictive accuracy of VLMs using various methods, including zero‑shot on raw data, zero‑shot on graph data, few‑shot learning, qualitative labeling, and chain‑of‑thought reasoning. Despite multiple methodological enhancements, predictive performance remains modest, revealing significant challenges in quantitative interpretation of visualized temporal data by current multimodal models. We demonstrate that standardizing input tokens by using graph images rather than …

A First Look Into Parental Strategies, And Challenges Around Children’S Device Usage In Urban Nepal, Rizu Paudel, Prakriti Dumaru, Ankit Shrestha, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

There have been substantial changes in the landscape of technology use by children in Global South during COVID-19, when the shift to online learning platforms necessitated parents to avail personal devices (e.g., smartphones, computers) for their children to fulfill their educational needs. However, the use of devices by children are not limited to serving educational purpose only. Our study positions itself in a critical post-pandemic period in Nepal, characterized by the increase in device use by children, while a little study to date, investigated parental mediation in this developing country. To this end, we conducted semi-structured interviews with 20 parents, …

Motionteller: Multi-Modal Integration Of Wearable Time-Series With Llms For Health And Behavioral Understanding, Aiwei Zhang, Arvind Pillai, Andrew Campbell, Nicholas C. Jacobson

Computer Science Senior Theses

As wearable sensing becomes increasingly pervasive, a key challenge remains: how can we generate natural language summaries from raw physiological signals such as actigraphy - minute-level movement data collected via accelerometers? In this work, we introduce MotionTeller, a generative framework that natively integrates minute-level wearable activity data with large language models (LLMs). MotionTeller combines a pretrained actigraphy encoder with a lightweight projection module that maps behavioral embeddings into the token space of a frozen decoder-only LLM, enabling free-text, autoregressive generation of daily behavioral summaries.

We construct a novel dataset of 54,383 ⟨actigraphy, text⟩ pairs derived from real-world NHANES recordings, and …

Re: Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) 2022 Draft Final Insufficiently Reclaimed Sites Sampling: Bres No. 37 – Josephine Shaft Site Evaluation Summary Report (December 6, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Response To Comment Letter For The Butte Priority Soils Operable Unit (Bpsou) Butte Reclamation Evaluation System (Bres) Draft 2024 Field Evaluation Summary And Technical Recommendations Report (Dated April 10, 2025), Abby Peltomaa

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2025 Residential Metals Abatement Program (Rmap) Rock Creek Cattle Company Borrow Submittal #1 (Dated May 23, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter With Comment For The Butte Priority Soils Operable Unit (Bpsou) 2025 Revised Draft Final Unreclaimed Sites: Ur-03 Site Remedial Action Work Plan (Rawp) (Dated June 2, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Enhancing Iot Decentralization With Iota 2.0: A Dag-Based Fast Probabilistic Consensus Framework, Ayat N. Kadhum, Ahmed M. Al-Salih

Journal of Intelligent Informatics, Networking, and Cybersecurity

The integration of IoT and blockchain enhances security, trust, and data integrity but is hindered by security attacks, scalability, and high latency. In this work, a more efficient method of consensus using Directed Acyclic Graph (DAG)-based Fast Probabilistic Consensus (FPC) and Edwards-Curve Digital Signature Algorithm (EdDSA) is proposed to yield better security, efficiency, and decentralization. By eliminating mining, resource use is optimized, and consensus is hastened. Experimental results show a high throughput of 7228.05 Transactions Per Second (TPS), rapid consensus formation in just 7.62 rounds on average, and high adversary resilience, with the system successfully mitigating 89% of adversarial attacks. …

Detecting Physical Activity Using Wearable Sensor Data, Dipok Deb

Data Science and Data Mining

This study focuses on detecting physical activity using wearable sensor data, specifically distinguishing between walking and running. A dataset comprising accelerometer and gyroscope readings is used to train and evaluate various machine learning models, including logistic regression, random forest, k-nearest neighbors, naïve Bayes, and XGBoost. Extensive preprocessing, such as creating lag features and rolling statistics, is performed to enhance temporal data representation. The models are evaluated using metrics like accuracy, precision, recall, and F1 score. Incorporating lag and rolling features significantly improves model performance, with logistic regression achieving perfect scores across all metrics. These findings demonstrate the effectiveness of enhanced …

Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney

Watershed Sciences Faculty Publications

Microplastics are found in Earth's atmosphere, lithosphere, hydrosphere, pedosphere, and ecosphere. While there is a growing interest and need to solve this grand challenge in both the academic and policy realms, few have engaged with academics, policymakers, and community partners to co-identify the problem, co-design research, and co-produce knowledge in tackling this issue. Using a convergence research framework, we investigated the perception of microplastic pollution among different end users, delivered educational materials to K-12 teachers and practitioners, and identified key sampling points for assessing environmental microplastic concentrations in the Columbia River Basin, United States. Three community partner workshops identified regional …

Cross-Modality Learning For Predicting Ihc Biomarkers From H&E-Stained Whole-Slide Images, Amit Das

Computer Science Senior Theses

Hematoxylin and Eosin (H&E) staining is a cornerstone of pathological analysis, offering reliable visualization of cellular morphology and tissue architecture for cancer diagnosis, subtyping, and grading. Immunohistochemistry (IHC) staining, an important ancillary study, provides molecular insights by detecting specific proteins within tissues, enhancing diagnostic accuracy, and improving treatment planning. However, IHC staining is costly, time-consuming, and resource-intensive, requiring specialized expertise. To address these limitations, this study proposes HistoStainAlign, a novel deep learning framework that predicts IHC staining patterns directly from H&E whole-slide images (WSIs) by learning joint representations of morphological and molecular features. The framework integrates paired H&E and IHC …

Biomarker-Guided Imaging And Ai-Augmented Diagnosis Of Degenerative Joint Disease, Rahul Kumar, Kyle Sporn, Aryan Borole, Akshay Khanna, Chirag Gowda, Phani Paladugu, Alex Ngo, Ram Jagadeesan, Nasif Zaman, Alireza Tavakkoli

Department of Medicine Faculty Papers

Degenerative joint disease remains a leading cause of global disability, with early diagnosis posing a significant clinical challenge due to its gradual onset and symptom overlap with other musculoskeletal disorders. This review focuses on emerging diagnostic strategies by synthesizing evidence specifically from studies that integrate biochemical biomarkers, advanced imaging techniques, and machine learning models relevant to osteoarthritis. We evaluate the diagnostic utility of cartilage degradation markers (e.g., CTX-II, COMP), inflammatory cytokines (e.g., IL-1β, TNF-α), and synovial fluid microRNA profiles, and how they correlate with quantitative imaging readouts from T2-mapping MRI, ultrasound elastography, and dual-energy CT. Furthermore, we highlight recent developments …

Level Of Service Criteria For Urban Arterials With Heterogeneous And Undisciplined Traffic Streams, Afzal Ahmed, Farah Khan, Syed Faraz Abbas Rizvi, Fatma Outay, Muhammad Faiq Ahmed, Muhammad Adnan

All Works

Accurate evaluation of the prevailing traffic operations plays an important part in developing sustainable transport systems. This research examines the suitability of the level of service (LOS) criteria developed by the Indian and United States (US) Highway Capacity Manuals (HCM) for heterogeneous and undisciplined traffic streams and proposes new criteria using a data-driven approach. Traffic data were collected from a selected major arterial in Karachi, and fundamental diagrams were developed using these data. These fundamental diagrams and field-collected data were analyzed using the K-mean clustering approach to examine the actual traffic states at various LOS bands used in practice. Associating …

Investigation Of A Polymer-Based Holographic Grating For Visible Light Dosimetry Using A Bleachable Dye, Saoirse Maher, Denise Denning, Jackie Mccavana Dr., Seán Cournane Dr., Suzanne Martin Dr., Dervil Cody

Conference Papers

Holographic sensors are of interest for a range of sensing tasks because of their high sensitivity, rapid response time, broad dynamic range, lightweight characteristics, and design flexibility. The practical application of holography makes it possible to design optical sensors that are effective in the visible and near-infrared ranges. The objective of this research is to construct a holographic grating that is customised to provide quantitative data in visible light dosimetry applications. Upon exposure to visible light, the proposed holographic grating will produce a measurable change in diffraction efficiency based on the bleaching of the grating material. In the evolution of …

Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski

Publications and Research

Recognizing that libraries serve multiple constituencies and subject areas, this chapter documents and advocates for development of transdisciplinary arts-based research (ABR) and culture-related projects linked to environmental challenges. Libraries contribute collections and spaces, as well as the research of library and information scientists. Libraries are currently among invisible contributors to sustainability planning and services. The chapter will link this invisibility to the value of what visual arts refer to as negative space elements in subjects ranging from traditional ecological knowledge to environmental science. Library collections, projects, and research contribute to education for sustainable development (ESD) as required to achieve the …

Having A Cow: Exploring The Economic And Mental Health Challenges Of Dairying In The Upper Valley, Ava J. Ori

Environmental Studies Senior Theses

Until late in the 20th century, the dairyman was an influential actor in the fabric of the Upper Valley consisting of Grafton, Orange, Sullivan and Windsor counties (Rozwenc, 1981 & Weld, 1905). Dairy farmers were critical to both the economic growth of the region and the construction of a local identity centered around distinctive high quality dairy products. However, the dairy farmers responsible for the bucolic feel and scrappy independence unique to the Upper Valley are being traded in for massive operations lacking both quality of milk and the cultural intricacy specific to local dairies. In 1905 there were 4,173 …

Molecular Insights Into The Role Of Estrogen Receptor Beta In Ecdysterone Mediated Anabolic Activity, Syeda Sumayya Tariq, Madiha Sardar, Muhammad Shafiq, Hendrick Heinz, Mohammad Nur-E-Alam, Aftab Ahmad, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

Ecdysterone, often dubbed a “natural steroid,” has garnered significant attention among athletes for its reputed growth-promoting and anabolic properties. Unlike synthetic anabolic steroids, which are classified as controlled substances, ecdysteroids remain largely unregulated in many countries and are widely marketed as dietary supplements. Notably, ecdysterone has been included in the World Anti-Doping Agency (WADA) monitoring program, highlighting its potential impact on athletic performance and raising questions about its regulation. Emerging evidence indicates that, unlike traditional anabolic steroids that act primarily via the Androgen Receptor (AR), ecdysterone’s anabolic effects may be mediated through Estrogen Receptors (ERs), particularly Estrogen Receptor beta (ERβ). …

The Ecophysiology Of The Enigmatic Namib Succulent, Lithops Ruschiorum, Garrett Macleod Althausen

Environmental Studies Senior Theses

Water availability is the primary constraint for plant survival and reproduction in hyper-arid ecosystems. In such environments, plant fitness depends on an alignment between physiological traits and limited water resources. The Namib Desert of Namibia exemplifies this extreme selection pressure. Within the Namib Desert, Lithops ruschiorum, a succulent endemic to the gravel plains, exhibits habitat specificity and numerous physiological adaptations to cope with the hyper-aridity.

This research explores the intersection of two fitness strategies for L. ruschiorum: habitat selection and exploitation of alternative moisture sources. The first chapter explores the population dynamics and micro-site habitat conditions preferred by …

Microwave-Assisted Synthesis And Surface Characterization Of Graphene Oxide-Antimony Trioxide Nanocomposites For Ascorbic Acid Electrochemical Sensor, Samir Mallick

Tennessee State University Alumni Theses and Dissertations

The detection and monitoring of Ascorbic Acid (AA) concentration is of crucial importance. Abnormal AA levels in bodily fluids have been reported to cause cancer, cardiovascular diseases, and Alzheimer’s and Parkinson’s diseases. Nanoparticles have played a critical role in developing affordable, sensitive, and selective sensors. This work reports on the electrochemical detection of AA using glassy carbon electrodes (GCEs) modified with microwave-assisted graphene oxide-antimony trioxide nanocomposite and chitosan films. The developed sensor displayed enhanced electron transfer and a better electrocatalytic reaction towards AA compared to other fabricated electrodes. Cyclic voltammetry and chronoamperometry were used for electrochemical measurements. CV and Fourier …

Deep Imputation Of Missing Values Using Feature And Sample Attention, Ibna Kowsar

Tennessee State University Alumni Theses and Dissertations

The handling of missing values is a pervasive challenge in tabular data sets, particularly in electronic health records (EHR), where incomplete data can hinder predictive modeling. Data with missing values are unfit for machine learning, whereas the imputation of missing values affects data quality and data-driven outcomes. Traditional statistical and machine learning-based imputation techniques often struggle with high missing rates and complex missing patterns. This thesis investigates the deep learning of attention between features and between samples in missing value imputation. These two attention mechanisms jointly capture the row-column structure of tabular data. It presents a novel deep learning framework …

Harmful Algae In Nashville’S Urban Watersheds: Challenging Traditional Monitoring Programs, Devin Matthew Moore

Tennessee State University Alumni Theses and Dissertations

As climate change intensifies, harmful algal blooms (HABs), specifically the species that produce microcystin-producing cyanobacteria, are becoming more frequent in urban environments. In the current state of HAB research, most monitoring and research is focused on agricultural areas. This study challenges traditional monitoring practices by evaluating the presence and abundance of microcystin in urban water bodies within Nashville, TN. Using field sampling, passive toxin tracking, ELISA testing, and GIS- based environmental and demographic analysis, data were collected at sites in densely populated areas. These sites were located at Tennessee State University, Ted Rhodes golf course and Shelby bottoms Park, and …

"Opting Out Of Ai”: Exploring Perceptions, Reasons, And Concerns Behind Faculty Resistance To Generative Ai, Aya Shata

Hank Greenspun School of Journalism and Media Studies Faculty Research

Research on Generative Artificial Intelligence (GAI) in higher education primarily focuses on faculty use and experiences, with limited attention given to why some abstain from using it. Drawing from Innovation Resistance Theory, this study aims to address this gap by exploring the perceptions of both faculty users and non-users of GAI, identifying the reasons and concerns why they avoid GAI. A survey of 294 full-time higher education faculty from two mid-size U.S. public universities was conducted. Using qualitative and quantitative analysis, results show that over one-third of the faculty members opted out of using GAI for five primary reasons: not …

Video Game Hacking, A General Problem With Generalized Solutions, Luke Rowe

Master's Theses

As video games continue to get more popular and lucrative, the number of malicious actors seeking to exploit them grows with it. As this industry expands, so does the importance of securing games against cheating and abuse. This thesis aims to educate developers to help mitigate the abuse of video games by these malicious actors. The goal of this thesis is to provide a foundational framework for thinking like a hacker and how to make games harder to abuse once a hacker bypasses conventional anti-cheat software.

This thesis outlines some of the most common cheating methods and provides general context …