Digital Commons Network^™

Modeling Musculoskeletal Combat Casualty Care: Nato Trauma System Performance In Large Scale Combat Operations, Mark P. Cote, Kaitlyn E. Holly, Roman J. Schoenfeld, Matthew R. Bryan, Malina O. Hatton, Mitchel B. Harris, Tracey P. Koehlmoos, Andrew J. Schoenfeld

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: It is unclear whether the current North Atlantic Treaty Organization (NATO) trauma system will be effective in the setting of Large-Scale Combat Operations (LSCO). We sought to model the efficacy of the NATO trauma system in the setting of LSCO. We also intended to model novel scenarios that could better adapt the current system to LSCO.

METHODS: We developed a discrete-event simulation model for patients with combat musculoskeletal injuries treated within the standard NATO system. The primary outcome of the model was survival. The model's health states were characterized as stable, hypovolemia, sepsis, shock, or death. The model simulated …

An Adaptive Force Matching Potential For Alanine Developed With Møller-Plesset Perturbation Theory And Smooth Fourier Transform Correction Map, Ying Yuan, Feng Wang

Chemistry & Biochemistry Faculty Publications and Presentations

Developing accurate force fields for biomolecules remains a significant challenge due to the subtle energetic differences between various conformational states. We present a novel force field model for polyalanine, ALAMP2_25, developed using adaptive force matching (AFM) with M & oslash;ller-Plesset perturbation theory at the second order (MP2) as the reference method. By fitting smaller model compounds and transferring parameters to larger peptides, we overcome the limitations of traditional AFM approaches and enable the use of more accurate electronic structure methods. The ALAMP2_25 model incorporates a new correction scheme, Smooth Fourier Transform-based phi, psi correction map (SFT-CMAP), which efficiently describes phi, …

Bayesian Survival Analysis For High-Dimensional Compositional Data, Zhenying Ding

All ETDs from UAB

Survival analysis integrating microbiome and clinical data offers powerful insights into human health. The microbiome influences immunity, inflammation, and cancer outcomes. Combining microbial profiles with clinical factors like tumor stage, treatment, and demographics enhances understanding of how host-microbe interactions affect survival. To analyze these complex datasets, advanced statistical methods, including Bayesian models, penalized Cox proportional hazards models, and machine learning techniques are employed. These approaches can uncover novel biomarkers and therapeutic targets, leading to personalized treatment strategies that optimize patient survival. However, challenges arise due to the compositionality, high-dimensionality, and phylogenetic relation between taxa in microbiome data. In this dissertation, …

Bayesian Mediation Analyses For Zero-Inflated Data, Jinhong Cui

All ETDs from UAB

Mediation analysis is a fundamental tool in causal inference, enabling researchers to disentangle the pathways through which an exposure affects an outcome via intermediate variables (mediators). It has been widely applied in social sciences, psychology, and healthcare-related studies. Traditionally, mediation analysis has been conducted within the linear structural equation modeling (LSEM) framework. However, recent advances have shifted attention toward the counterfactual framework due to its flexibility in defining causal effects and its capacity to accommodate non-linear relationships, parametric and non-parametric models. Building on this foundation, methodological developments in mediation analysis have expanded to address more complex data structures, such as …

Mcl1 And Hexokinase 2 Form A Glucose Metabolic Regulatory Axis, Robert Lee

All ETDs from UAB

Hexokinase 2 (HK2) initiates glucose metabolism by catalyzing the conversion of glucose to glucose-6-phosphate providing the starting substrate for a vast array of metabolic pathways such as glycolysis, pentose phosphate pathway (PPP), amino acid biosynthesis and others. While HK2’s metabolic role in normal physiologic function (such as in cardiomyocytes) and cancers (through driving the Warburg Effect) are well established, there is emerging evidence that supports HK2 is also a critical mediator of protein-protein interactions that regulate cell survival. Through comprehensive review, we explore how HK2 contributes to cell survival through metabolic and protein scaffolding roles. We also investigate a novel …

A Comparison Of Shear Bond Strength Of Denture Teeth To Denture Base Using Different Means Of Retention: An In Vitro Pilot Study, Dima Taha El Baba, Paul Boulos

International Arab Journal of Dentistry

Objectives: The objective of this work is to evaluate the shear bond strength between denture base resin and three different acrylic artificial denture teeth. The latter was subjected to three different surface modifications on the ridge lap area and compared to unmodified acrylic artificial denture teeth.

Methods: In this experimental in vitro study, twenty-four maxillary central incisor acrylic teeth were used from each of three manufacturers; namely Major®, Ivoclar® and Myerson®. The teeth were additionally divided into four test groups with six specimens in each: a control group, a chemical retention group, a mechanical retention group, and a …

Moving Forward With Maboo Liyan Boorroo: River Monitoring And Communicating Heritage And River Keeper Stories: Research Workshop Iii Summary Report, Anne Poelina, Tod Jones, Martin Brueckner, Pierre Horwitz, Sven Ouzman, Kylie Wrigley, Community Research Practioners - Martuwarra River Keepers

Reports accepted as research outputs

This Report provides a summary of activities and outcomes from the Maboo Liyan Boorroo Workshop III, held in June 2025. Three community Workshops have been held, involving an external multi-disciplinary and multi-institutional research team (the research team) visiting and working with the Yurmulun Pandanus Park Community and the Martuwarra Fitzroy River Council River Keepers. This visit followed two workshops with the community held in November 2021 (see Voices for the Martuwarra: Mapping Values with Fitzroy River Communities, 2021) and August 2022 (see Working together for Maboo Liyan Boorroo, 2022). This summary report provides detail on Workshop III discussions, activities and …

Matrescence, Erin Kunz

The Cicadian

Kunz reflects on her transformation into motherhood, describing the physical, emotional, and psychological shifts that accompany the process known as matrescence. Through vivid memories of childhood and early parenting, she explores the complexities of maternal love, especially for women who did not receive unconditional love themselves. Her rocking chair becomes a symbol of nurturing and endurance, where she gave everything to her children while grappling with her own identity. Erin also highlights the supportive role of her partner, challenging traditional gender norms and celebrating shared caregiving. As her children grow, she mourns the environmental changes that have altered the …

Geographic Disparities In Birth Outcomes: County-Level Investigation On Pm2.5 And Low Birth Weight In The United States, Eunice Y. Park, Ranju Mainali

Department of Public Health Scholarship and Creative Works

Exposure to air pollution adversely affects health and is highly associated with birth outcomes. This study analyzes the relationship between air pollution and low birth weight (LBW; less than 2,500 g at birth) at the county level in the United States. Using the latest publicly available data from the County Health Rankings and Roadmaps across 3,027 counties and equivalents, simple and quantile regression analyses were conducted to test the association between the average daily density of fine particulate matter (PM2.5) and LBW. The LBW data were from 2016 to 2022 from the National Center for Health Statistics and PM2.5 data …

Intelligence Architectures And Machine Learning Applications In Contemporary Spine Care, Rahul Kumar, Conor Dougherty, Kyle Sporn, Akshay Khanna, Puja Ravi, Pranay Prabhakar, Nasif Zaman

SKMC Student Presentations and Publications

The rapid evolution of artificial intelligence (AI) and machine learning (ML) technologies has initiated a paradigm shift in contemporary spine care. This narrative review synthesizes advances across imaging-based diagnostics, surgical planning, genomic risk stratification, and post-operative outcome prediction. We critically assess high-performing AI tools, such as convolutional neural networks for vertebral fracture detection, robotic guidance platforms like Mazor X and ExcelsiusGPS, and deep learning-based morphometric analysis systems. In parallel, we examine the emergence of ambient clinical intelligence and precision pharmacogenomics as enablers of personalized spine care. Notably, genome-wide association studies (GWAS) and polygenic risk scores are enabling a shift from …

Impact Of Black Shale Weathering On Stream Water And Sediment Quality In Eastern Kentucky, Brett Hopt

Dissertations and Theses

Black shales contain high concentrations of trace elements in addition to their elevated organic carbon content. Once exposed at the surface, weathering processes release these elements into the environment, including many (e.g., As, Cu, Cd, Cr, U, Zn) that could pose threats to human and environmental health. Previous studies have focused on how these metals are incorporated into the soil column and their effects on crop nutrition. However, few studies have focused on the impact of natural weathering of black shales on local stream water chemistry and the transport and subsequent partitioning of these geogenic contaminants into stream environments.

This …

The Impact Of Public Relations Strategies On The Effectiveness Of Epidemic Management In Jordan: A Case Study Of Covid-19, Hazem Jamil Al-Rahahleh

Middle East Journal of Communication Studies

This study aimed to explore the impact of public relations strategies on the effectiveness of epidemic management in Jordan, using the COVID-19 pandemic as a case study. The study employed the descriptive-analytical method, which is based on the systematic description and interpretation of social and media phenomena. The findings revealed that public relations play a pivotal strategic role in managing health crises by building public trust, preparing communication plans, and formulating awareness messages in coordination with relevant authorities. The study recommended the need to enhance the training of public relations personnel in managing communication during health crises, to continue diversifying …

Experiential Learning: Innovative Approaches To Post-Secondary Cybersecurity Education, Brendan Bertone, Paul Wagner, Joshua Pauli

Journal of Cybersecurity Education, Research and Practice

The cybersecurity profession continues to face a significant shortfall of qualified professionals despite steady growth in degree programs. Employers consistently cite experience as the main barrier for entry-level cybersecurity hires. This paper argues that clinic-based experiential learning offers a scalable solution to that preparation gap. A systematic literature review spanning academic and professional literature was conducted to examine: (1) barriers to entry for aspiring cybersecurity professionals; (2) the effectiveness of experiential learning compared to traditional instruction; and (3) the viability and scalability of cybersecurity clinics. Screening emphasized workforce development, experiential pedagogy, and alignment with the NICE Cybersecurity Workforce Framework. Findings …

09.08.2025 Ored Connect, Liz Williamson

ORED Newsletter

• Researcher training opportunities
• Project to increase PhD student success
• ORED online training opportunities

Re: Butte Priority Soils Operable Unit (Bpsou) Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 18 – Walkerville Ballfield, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 26 – Cripple Dump (Dated August 21, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Settling Defendants Bmfou Annual Report Consent Decree For The Butte Mine Flooding Site Cd, Cv 02-35 Bu-Rfc Remedial Action – Implementation Of The Remedy Horseshoe Bend Water Treatment Plant 2024 Annual Report, Mark Thompson, Dave Griffis

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Air Pollution And Diseases: Signaling, G Protein-Coupled And Toll Like Receptors, Isabella Cattani-Cavalieri, Katrina F. Ostrom, Jordyn Margolis, Rennolds S. Ostrom, Martina Schmidt

Pharmacy Faculty Articles and Research

Air pollution is a significant public health issue that impacts lung health, particularly in vulnerable populations such as children, the elderly, and individuals with pre-existing respiratory conditions. Both natural and anthropogenic sources of air pollution give rise to a variety of toxic compounds, including particulate matter (PM), ozone (O₃), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), and polycyclic aromatic hydrocarbons (PAHs). Exposure to these pollutants is strongly associated with the development and exacerbation of respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF). Notably, early life exposure to pollutants such as …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 100 – Capri Motel-Arctic Dump (Dated August 12, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Comment Letter For The Draft Final Butte Priority Soils Operable Unit Unreclaimed Sites New And Mahoney (Ur-23) Construction Completion Report., Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 18 – Walkerville Ballfield (Dated August 13, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp): Bres No. 120 – Bonanza Dump, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Information Security Awareness And Behavior Of Smartphone Users In The Ibadan Metropolis, Nigeria, Funmilola Olubunmi Omotayo

Journal of Cybersecurity Education, Research and Practice

Today, there is a rapid increase in the number of people using the Internet via smartphones and relying on them for most of their daily activities. Consequently, smartphones are becoming the target of criminals for atrocious purposes. This study investigated the information security awareness and behavior of smartphone users in the Ibadan metropolis, Nigeria. The study adopted a descriptive survey design. Data was collected with a questionnaire from 400 respondents who were conveniently selected. Findings revealed that most smartphone users knew about the smartphone security features available on their phones. However, most also engaged in behaviors that threatened their information …

Emerging Clinical Role Of Tavapadon, A Novel Dopamine Partial Agonist, In The Treatment Of Parkinson’S Disease, Alan D. Kaye, Bennett M. Ford, Brennan M. Abbott, Kalob M. Broocks, Sofia Novacic, Sahar Shekoohi

School of Medicine Faculty Publications

Tavapadon, a novel oral dopamine-D1R/D5R partial agonist, has been studied in recent years for the treatment of late-stage development Parkinson’s disease (PD). Levodopa, a dopamine precursor that currently remains the gold-standard first-line therapy for PD motor symptoms, serves as a benchmark against emerging dopaminergic agents. By selectively activating D1-family receptors on direct-pathway medium neurons, Tavapadon differs in that it delivers levodopa-level motor benefit while avoiding its many D2R/D3R-mediated adverse effects. In placebo-controlled trials, Tavapadon produced clear, clinically meaningful gains in motor function and day-to-day activities, as captured by the Unified Parkinson’s Disease Rating Scale (UPDRS). Recent late-stage results have revealed …

09.02.2025 Ored Connect, Liz Williamson

ORED Newsletter

• NIH Specific Aims Statement RED Talk
• NSF Research Security Training 

Deep Learning-Driven Proteomics Analysis For Gene Annotation In The Renin-Angiotensin System, Mortaza Eivazi, Kamran Hosseini, Shahin Alipanahi, Huijing Xia, Luke Restivo, Ayushi Patel, Mahdieh Gozali, Tahereh Ebrahimi, Amy Scarborough, Vahideh Tarhriz, Eric Lazartigues

School of Medicine Faculty Publications

The renin-angiotensin system (RAS) is central to cardiovascular diseases such as hypertension and cardiomyopathy, yet the functions of many RAS genes remain unclear. This study developed a multi-label deep learning model to systematically annotate RAS gene functions and elucidate their roles in biological pathways. A total of 39,463 RAS-related publications from PubMed and PMC were processed into text format. Feature matrices were generated using TF-IDF and token processing, followed by dimensionality reduction via Principal Component Analysis (PCA). A Multi-Layer Perceptron (MLP) was applied for multi-label classification, with performance evaluated using Precision, F1-Score, Ranking Loss, and ROC-AUC metrics. The model outperformed …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Revised Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 120 – Bonanza Dump (Dated August 12, 2025), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Fun! Friends! Famous People! Why Fans Attend Anime Conventions, Billy Tringali, Maria Alberto, Jeremiah Martinez

Proceedings from the Document Academy

In 2021 during the global Covid-19 lockdowns, Billy and Maria ran an IRB-exempted online survey, looking to hear from fans who attend anime conventions. Conventions had been shut down as non-essential services that drew large crowds, and we hoped to capture a screenshot of this moment, to better learn from it in the future. And the resulting data collection went quite well – we were able to partner with a major anime organization to share the survey, and our 1000+ respondents had a lot to say about the conventions they were missing during lockdowns.

Ultimately, we found a significant emphasis …

Utilizing Generative Ai To Counter Learner Groupthink By Introducing Controversy In Collaborative Problem-Based Learning Settings, Andrew Wiss, Mary Showstark, Kyle Dobbeck, Jennifer Pattershall-Geide, Elke Zschaebitz, Dawn Joosten-Hagye, Kirsten Potter, Erin Embry

Montclair State University Scholarship & Creative Works

This article highlights the foundational challenge of rapid interprofessional student team formation and the potential challenges that groupthink poses for newly-formed teams participating in collaborative problem-based learning activities. This article describes a mixed-methods study that addresses groupthink by introducing a generative artificial intelligence-based agent (genAI agent) into the small group processes of student teams engaging in a session of a well-established virtual interprofessional education methodology. The integration of this novel genAI tool into each student team was an intentional pedagogical technique, introduced in response to the challenges that newly-formed student teams may encounter as they rapidly come together and potentially …

Lead Exposure In The 21st Century: Modeling A Path From Crisis To Prevention, Danlin Yu

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

No abstract provided.