Digital Commons Network^™

Development Of Minimalist Trifunctional Building Blocks For Chemical Biology Probe Synthesis, Luke E. Bohrer

Electronic Theses and Dissertations

The completion of the Human Genome Project in 2003 generated expectations that genomic information would accelerate the discovery of new protein drug targets and FDA-approved therapies. However, many small-molecule drug candidates continue to fail in clinical trials, and much of the human proteome remains undercharacterized in terms of structure, function, and disease relevance. Chemical tools are therefore essential for defining protein function, mapping protein interactions, and identifying disease-associated molecular mechanisms. Among these tools, small-molecule chemical probes provide a powerful strategy for connecting biological activity with target identification, functional analysis, and the development of effective therapies.

This dissertation describes the development …

Re: Comment Letter For The Draft Final Butte Priority Soils Operable Unit (Bpsou) Butte Treatment Lagoons (Btl) Groundwater Treatment System Quarterly Operation And Maintenance Report – Quarter 1 2026 (Dated June 26, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Role Of Trauma-Informed Care In Supporting At-Risk Students In Alternative Education, Jar'mel D. Taylor Dr.

Transformations

Students with traumatic experiences commonly fail to meet educational goals and control their emotions while also losing their involvement in classes. Standard trauma-informed care practices remain absent from numerous alternative educational institutions, which leaves their teaching community without adequate support to help traumatized students effectively. The application of Trauma-Informed Care (TIC) strategies toward student outcomes requires investigation to develop effective educational approaches that enhance school success. The researcher used qualitative exploratory case study methodology to study TIC practices in alternative education for Black and Brown adolescent students (aged 12–18) in Washington, D.C. Semi-structured interviews and a focus group with 16 …

65th Annual Rocky Mountain Conference On Magnetic Resonance

Rocky Mountain Conference on Magnetic Resonance

Conference program, abstracts, and information about the 65th annual meeting of the Rocky Mountain Conference on Magnetic Resonance. Held in the Snowbird Resort and Conference Center, Snowbird, Utah, August 2-6, 2026.

A Coupled Reaction-Diffusion Model Of Promoting And Suppressing Interactions Among Cancer Hallmarks In Endometrial Cancer, Jeddy Bennett

Theses and Dissertations

Spatial transcriptomics enables the scoring of Cancer Hallmarks at a high resolution across a tissue biopsy, yet current analyses of these data remain largely descriptive, treating each spot as a static, independent observation. This thesis develops a coupled system of advection-diffusion-reaction partial differential equations to model the hallmark landscape as the steady-state solution of an underlying spatial process, and casts the recovery of its physical parameters as a PDE-constrained inverse problem. The framework is implemented in FEniCSx on tissue-specific finite element meshes derived from two endometrial cancer biopsies provided by the Huntsman Cancer Institute, with subdomains, boundary interfaces, and an …

The 2025 Measles Outbreak In Texas, Tamer Oraby, Martial L. Ndeffo-Mbah

School of Mathematical & Statistical Sciences Faculty Publications

Background

In 2025, Texas experienced its largest measles outbreak in decades, reporting 762 cases by mid-August. Measles is a highly contagious but vaccine-preventable infection transmitted mainly among unvaccinated individuals and capable of causing severe outcomes.

Methods

We investigate counterfactual measles control scenarios based on daycare and school closures and reactive vaccination of infants and children, including mixed interventions. We analyze the 2025 Texas outbreak using an age-structured multi-stage SEIR model formulated as a system of ordinary differential equations. The model is fit to case data using Bayesian inference to estimate the effective reproduction number and generate posterior predictive trajectories under …

Assessing The Impact Dynamics Of Less Lethal Ammunition, Steven Bermejo

Student Theses

Less-lethal ammunition is widely used by law enforcement as an alternative to lethal force during crowd control, on-street confrontations, and other situations requiring force. Although these projectiles are intended to reduce risk of fatal injury, serious injuries and fatalities have been reported, highlighting the need to better understand the factors that influence their impact behavior. This study evaluated the impact dynamics of four types of 12-gauge less-lethal ammunition, including rubber buckshot, single rubber ball, double rubber ball, and Byrna kinetic projectile, using kinetic energy calculations derived from projectile mass and velocity measurements. In addition, Attenuated Total Reflectance Fourier Transform Infrared …

From Reluctance To Resilience: The Link Between Attitude And Growth Mindset In Calculus Students, Olivia Valente, Kathryn E. Pedings-Behling, Amy N. Langville

Journal of Educational Research and Practice

Many postsecondary students enter general education mathematics courses with negative attitudes, shaping their willingness to engage with the content. This study explores the relationship between students’ attitudes towards mathematics and their growth mindset, revealing effective strategies to enhance learning experiences, particularly for students who are reluctant learners. The research investigates two questions: (1) How do students’ Attitude Toward Mathematics Inventory (ATMI) scores and Growth Mindset Scale (GMS) scores relate? and (2) Do gender or course modality affect this relationship? This study addresses a gap in literature by examining how enjoyment, motivation, self-confidence, and perceived value connect with growth mindset. The …

Closing The Awareness–Behavior Gap: A Role-Based Phishing Training Framework For Higher Education, Ranylene O. Olaybal, Ryan A. Olaybal

Journal of Cybersecurity Education, Research and Practice

Phishing remains one of the most persistent cybersecurity threats facing higher education institutions, where diverse user populations and highly connected digital environments increase exposure to social engineering attacks. Although cybersecurity awareness initiatives are widely implemented, high awareness does not always translate into secure behavior. This study examined phishing awareness, phishing-related practices, phishing susceptibility, and phishing experiences among college students, teaching faculty, and administrative staff in a private higher education institution in the Philippines. Using a quantitative cross-sectional design, data were collected from 553 respondents through a validated survey instrument and analyzed using descriptive statistics, one-way analysis of variance, Tukey's honestly …

Statistical Methodologies For Count Time Series Analysis And Topological Data Analysis Of Medical Images, Yuhyeong Jang

Statistical Science Theses and Dissertations

This dissertation addresses two distinct topics related to count time series analysis and topological medical image analysis, respectively. The first part of the dissertation comprises an application of a count time series model to analysis of US monthly sex trafficking data and development of a new model for multivariate count data that exhibits serial dependence and overdispersion. By imposing a family of multivariate mixed Poisson distributions on the count random vector, the proposed model can accommodate a broad range of overdispersion as well as positive contemporaneous correlations. For maximum likelihood estimation, a computationally feasible EM-type algorithm is derived based on …

Single Fluorogens And Orientation-Localization Microscopy For Quantifying Chemical And Biomolecular Dynamics At The Nanoscale, Yiyang Chen, Yuanxin Qiu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Many chemical systems look uniform only because ensemble measurements average over their most interesting molecules. Electron-transfer rates vary across electrode surfaces; lipid membranes contain nanodomains with distinct packing and fluidity; peptide aggregates exhibit local polymorphism; and biomolecular condensates contain transient networks of interactions that are blurred in ensemble images. A central challenge in chemical imaging is not simply to see smaller structures, but to measure chemical variables such as polarity, redox potential, and molecular confinement at the single-molecule level. In this Account, we describe how fluorogens, molecules whose brightness, blinking, spectral shifts, orientation, rotational mobility, and motion are directly shaped …

Dynamics Of Microscale Droplets In Respiratory Airways, Md Shamser Ali Javed

Mathematics Theses and Dissertations

We investigate trajectories of microscale evaporating droplets in a stagnation point flow near a wall of a respiratory airway. The configuration is motivated by the problem of advection and deposition of microscale droplets of respiratory fluids in human airways during transmission of infectious diseases such as tuberculosis and COVID-19. Laminar boundary layer equations are solved to describe the air flow while the equations of motion of the droplet include contributions from gravity, aerodynamic drag, and Saffman force. Evaporation is accounted for at both the droplet surface and the wall of the respiratory airway and is shown to delay droplet deposition …

Butte Priority Soils Operable Unit Final 2024 Unreclaimed Sites Sampling: Ur-46 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Ai And The Music Industry: Its Current Status And A Speculative Projection Of Its Evolutionary Trajectory, Rhett D. Morris, Clayton Rosati, Stefan Fritsch

Honors Projects

Music serves as one of society's biggest cultural outlets, allowing millions to share in what used to be a uniquely human form of expression. The commodification of music has built a huge industry full of companies and platforms that have used technology and property laws to shape music's relationship with the public. This study aims to look into the future to see how AI and its implementation could affect the structure of the music industry. To look into the future, this piece establishes two of the most pressing kinds of AI technology for the music industry and looks to contextualize …

Changes In Water Quality And Microbiota Over Two Years In Florida Hard Clam (Mercenaria Mercenaria) Hatcheries, Bonnie Getter

Electronic Theses and Dissertations

This thesis characterized the water quality and bacterial communities in nine hard clam hatcheries over two production years through weekly or biweekly water quality and chemistry monitoring, monthly bacterial plating in the second year of production, and select 16S microbiome sampling at select hatcheries to address production bottlenecks and support the reliable production of high-quality seed for Florida’s growing hard clam aquaculture industry. Logistic regression models showed that water source was distinguished by pH, salinity, alkalinity, and nitrite, whereas geographic location was distinguished by temperature, salinity, nitrate, and calcium; temperature, dissolved oxygen, salinity, and alkalinity distinguished seasons. Vibrio bacteria differed …

Influence Of Transboundary Wildfire Smoke On Fine Particulate Matter Concentrations At South Texas Border Schools, Sai Deepak Pinakana, Kabir Bahadur Shah, Owen Temby, Dawid K. Wladyka, Juan L. Gonzalez, Md Saydur Rahman, Katarzyna Sepielak, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Exposure to air pollutants in indoor and outdoor school environments poses significant health risks to children due to their heightened vulnerability. Increasing wildfire frequency has intensified transboundary smoke transport, with border communities among the first to experience associated air quality impacts. While the impacts of wildfires on air quality are increasingly recognized through satellite observations and modeling, ground-based observations remain scarce in under-monitored regions. Low-cost air sensors were deployed across schools in the Roma and Rio Grande City areas of Starr County, along the U.S.–Mexico border, for 146-days from November 2023 to April 2024. The raw sensor measurements were corrected …

Clinical Utility Of An Fda-Authorized Artificial Intelligence Imaging Platform In Interstitial Lung Disease Diagnosis, Arjun Prakash Tambe, Ryan Boente, Gautam George, Fayez Kheir, Omid Tahamtani Omran, Kavitha Selvan

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

Background/Objectives: The diagnosis of interstitial lung disease (ILD) is challenging and frequently delayed. Clinically accessible and minimally invasive diagnostic tools are needed to expedite the diagnosis of ILD while minimizing risk to patients. Fibresolve is an imaging artificial intelligence (AI) tool recently approved by the Food and Drug Administration (FDA) for use in ILD diagnosis and made available to clinicians. The objective of this study was to describe its utility in clinical practice. Methods: We conducted a prospective, observational study of patients across the United States (US) in whom Fibresolve was utilized during routine clinical practice between July 2024 and …

Extreme Heat And Its Impact On Public Transit Ridership In Nyc, Craig Denton

Theses and Dissertations

This thesis explores the connection between extreme heat events and public transit ridership patterns in New York City, with a particular emphasis on low-income communities. It investigates the intersection of socioeconomic factors and heat-related challenges, analyzing how extreme temperature periods influence overall transit use and why certain routes or neighborhoods experience greater declines in ridership during these events.

Utilizing existing literature, NYC-specific transit and climate datasets, and the broader context of transit equity, this research aims to inform strategies that strengthen climate resilience within urban transportation systems. The study’s findings are intended to support policy development and planning initiatives that …

Final Bpsou Unreclaimed Sites: Ur-46 Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Revised Draft Final Butte Mine Waste Repository Operation And Maintenance (O&M) Plan, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Wavelet-Based Multiscale Analysis Of Cave Co₂ Concentration In Response To Short-Term High-Intensity Tourism Activities: Spatiotemporal Heterogeneity And Lag Characteristics, Mingda Cao, Wenwen Song, Yan Zhang, Jie Zhang, Zhiqiang Yao

International Journal of Speleology

High-intensity tourism activities can cause a significant increase in cave air CO₂ concentration, thereby affecting the cave micro-environment and secondary carbonate deposition. During the 2023 National Day Golden Week, high-frequency continuous monitoring of cave air CO₂ partial pressure (PCO_2(A)) and visitor numbers was conducted in Dawang Cave, Anhui Province. Wavelet transform and cross-correlation analyses were used to reveal the multi-scale response characteristics of CO₂ concentration to tourism activities. The results show that: (1) PCO_2(A) exhibited clear diurnal variations (higher during the day, lower at night) and decreased spatially with enhanced ventilation, controlled jointly by …

Temperature And Salinity Effects On The Physiology Of Bullfrog Tadpoles (Lithobates Catesbeianus) From A Suburban Temperate Wetland, Angela Brown

Theses, Dissertations and Culminating Projects

One of the most robust amphibians is the American Bullfrog, Lithobates catesbeianus, which is a widespread species that is invasive worldwide, and is broadly tolerant of a range of environmental conditions. Despite this tolerance, survival and performance of adult L. catesbeianus can be negatively affected by increasing temperatures and salinity resulting from anthropogenic impacts, such as climate change and road salts. This study focuses on the effects of acute salinity exposure (mimicking road salt influx into a pond) on L. catesbeianus tadpoles at different larval stages. Increased salinity was predicted to negatively affect two physiological performance measures. Critical maximum temperature …

Differential Effects Of Generative Artificial Intelligence On Formative And Summative Assessment Performance: A Quasi-Experimental Longitudinal Study, Md Istiak Morsalin

Master's Theses

Generative artificial intelligence has unsettled a core assumption of course assessment: that scores on unsupervised work reflect what students can do unassisted. This study tests whether the widespread availability of ChatGPT altered student performance differently on formative versus summative assessments in Business Analytics and Foundations, a required undergraduate quantitative-methods course taught by one instructor across nine cohorts. In a quasi-experimental longitudinal design, the Fall~2022 cohort ($n = 90$), the last to finish before ChatGPT's public release, serves as a control against eight post-ChatGPT cohorts spanning Spring~2023 through Summer~2025 ($N = 646$). Outcomes were drawn from McGraw-Hill Connect records using matched …

A Social-Ecological Systems Approach To Integrating Outdoor Recreation And Black Bear Management: A Michigan Case Study, Megan Dorothy Stone

All Graduate Theses and Dissertations, Fall 2023 to Present

Outdoor recreation sits at the intersection of social and ecological systems, representing one of the primary ways in which humans directly interact with their natural environment. As a result, outdoor recreation management must balance providing high-quality outdoor recreation opportunities while simultaneously protecting natural resources in protected areas. Balancing these concurrent management goals has become more challenging in recent years as participation in outdoor recreation increases. This can lead to numerous negative impacts on the environment, such as wildlife disturbance. In this study, I explore the challenges and opportunities for collaboration between managers of outdoor recreation and black bears in the …

Summary Report: Second Conference On Attribution Science And Climate Law, Jessica A. Wentz

Sabin Center for Climate Change Law

The Sabin Center for Climate Change Law and the Columbia Climate School hosted the Second Conference on Attribution Science and Climate Law at Columbia University on June 10–11, 2026. This event brought together an interdisciplinary group of researchers and practitioners to discuss recent developments in attribution science and the field’s relevance to climate law and policy. Participants included physical scientists, public health researchers, economists, social scientists, legal scholars, advocates, and policy experts. This report provides a written summary of the conference proceedings.

Bpsou Grove Gulch Sedimentation Bay Draft Remedial Action Construction Completion Report (Ccr), Woodard & Curran

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Dbssnet: Dual-Branch Spectral-Spatial Network With Data-Driven And Knowledge-Guided Band Selection For Uav Hyperspectral Wheat Rust Detection, Subin Kim

All Graduate Theses and Dissertations, Fall 2023 to Present

Wheat rust is a serious plant disease that can reduce crop yield and quality. In practice, the disease is often noticed only after visible symptoms appear, when some damage may already be difficult to reverse. This thesis studies whether drone-based imaging can help detect wheat rust earlier and more reliably in field environments. 

Unlike an ordinary color photograph, a hyperspectral image records reflected light at many narrow wavelengths. These measurements can reveal useful information about plant condition, but they are also high dimensional, noisy, and difficult to analyze when only a limited number of labeled field samples are available. To …

Pesticide Dissipation In Agroecosystems – Exploring Pesticide Fate And Transport Mechanisms To Protect Alternative Pollinators, Calvin Luu

All Graduate Theses and Dissertations, Fall 2023 to Present

Honey bees are the most well-known pollinators, but there exists thousands of other bee species that contribute to pollination; one such group of bees are the solitary bees. True to their namesake, solitary bees do not live in hives like honey bees. Some solitary bees, like alfalfa leafcutting bees (ALCB) and blue orchard bees, can pollinate crops more efficiently than honey bees. However, since they live solitary lives, pesticide exposure is much more harmful to their overall population. If one honey bee dies from pesticide exposure, the hive can still survive, and the queen bee will continue producing offspring. If …

Method Validation Of The Cdc Bottle Bioassay And A Historical Record Of Polycyclic Aromatic Hydrocarbons In Glacier National Park, Evah F. Peard

All Graduate Theses and Dissertations, Fall 2023 to Present

Certain contaminants can persist in the environment for long periods of time, build up within living tissues, travel far from their origin, and harm both ecosystems and organisms. This thesis focuses on two types of contaminants: insecticides and polycyclic aromatic hydrocarbons (PAHs). Insecticides are manufactured to control pests while PAHs are found in oil and gas products and can be produced by industry, vehicle engines, and wildfires. Understanding how harmful these contaminants are and where they end up in the environment is critical for protecting environmental health.

First, I evaluated a widely used test developed by the Centers for Disease …

Assessing Ecological Integrity Of Streams Across The Western U.S., Jennifer L. Courtwright

All Graduate Theses and Dissertations, Fall 2023 to Present

Large-scale assessments of stream health (ecological integrity) are required by policies such as the U.S. Clean Water Act and provide critical information needed to properly manage public lands. Our ability to quantify the ecological condition of streams in the western U.S. and identify the causes of degraded conditions has previously been impeded by a lack of standardized large-scale datasets, high natural temporal and spatial variability of ecological attributes, and poor-quality land use data. I compiled large-scale monitoring datasets and built models to predict the values of ecological attributes (metrics) at a given site in the absence of human impacts. In …