Digital Commons Network^™

Methionine-35 Of Aβ(1-42): Importance For Oxidative Stress In Alzheimer Disease, D. Allan Butterfield, Rukhsana Sultana

Chemistry Faculty Publications

Alzheimer disease (AD) is an age-related progressive neurodegenerative disorder. This devastating disease is characterized by the presence of senile plaques (SP), neurofibrillary tangles (NFTs), and loss of synapses. Amyloid beta-peptide 1–42 (Aβ(1–42)) is the main component of SP and is pivotal to AD pathogenesis. Brain of subjects with AD and arguably its earliest manifestation, mild cognitive impairment (MCI), demonstrate increased levels of oxidative stress markers. Our laboratory combined these two aspects of AD and MCI and proposed the Aβ(1–42)-associated free radical oxidative stress hypothesis to explain oxidative stress under which the MCI and AD brain exist …

Refinement Of Biomarker Pentosidine Methodology For Use On Aging Birds, Crissa K. Cooey, Jesse A. Fallon, Michael L. Avery, James T. Anderson, Elizabeth A. Falkenstein, Hillar Klandorf

United States Department of Agriculture Wildlife Services: Staff Publications

There is no reliable method for determining age for most species of long-lived birds. Recent success using the skin chemical pentosidine as a biomarker has shown promise as an aging tool for birds. Pentosidine levels have been determined only from the breast tissue of carcasses, and we sought to refine the procedure with respect to biopsy size and location for safe and effective use on living birds. We compared pentosidine concentrations in 4 skin-size samples (4, 6, 8, and 20-mm diameter biopsies) from the breast of black vulture (Coragyps atratus) carcasses. We also compared pentosidine levels from breast …

Ua56/1 Fact Book, Wku Institutional Research

WKU Administration Documents

Statistical and demographic profile of WKU.

Fall 2010, Nsu Oceanographic Center

Currents

No abstract provided.

Total Number Of Synapses In The Adult Human Neocortex, Thai Nguyen

Undergraduate Journal of Mathematical Modeling: One + Two

The brain is composed of glial cells and neurons where synapses form connections between neurons and other cells. Since synapses are very small, so either a light or electron microscope is required to see them. Unlike other mammals, synapses in the human brain deteriorate rapidly upon death making them difficult to study. This project constructs a simple model for the number of synapses in the human neocortex by age and sex based on the amount of neurons. This hypothetical model can also be used to study the impact of Alzheimer's disease and other forms of dementia that are marked by …

The Influences Of Cell Type And Zno Nanoparticle Size On Immune Cell Cytotoxicity And Cytokine Induction, Cory Hanley, Aaron Thurber, Charles Hanna, Alex Punnoose, Jianhui Zhang, Denise G. Wingett

Physics Faculty Publications and Presentations

Nanotechnology represents a new and enabling platform that promises to provide a range of innovative technologies for biological applications. ZnO nanoparticles of controlled size were synthesized, and their cytotoxicity towards different human immune cells evaluated. A differential cytotoxic response between human immune cell subsets was observed, with lymphocytes being the most resistant and monocytes being the most susceptible to ZnO nanoparticle-induced toxicity. Significant differences were also observed between previously activated memory lymphocytes and naive lymphocytes, indicating a relationship between cell-cycle potential and nanoparticle susceptibility. Mechanisms of toxicity involve the generation of reactive oxygen species, with monocytes displaying the highest levels, …

Ua35/1 Doers & Deeds Vol. 7, No. 10, Wku Provost

WKU Administration Documents

Newsletter created by the WKU Provost & Vice President of Academic Affairs to highlight the activities of faculty, staff and alumni.

Order-Restricted Covariate Effects And Hazard Regression Models., Arnab Bhattacharjee Dr.

Doctoral Theses

The proportional hazards (PH) model, but more speciÖcally its special case the Cox regression model (Cox, 1972), plays an important role in the theory and practice of lifetime and duration data analysis. This is because the PH model (and the Cox regression model) provides a convenient way to evaluate the ináuence of one or several covariates on the probability of conclusion of lifetime or duration spells. However, the PH speciÖcation substantially restricts interdependence between the explanatory variables and the lifetime in determining the hazard. In particular, the Cox regression model model restricts the coe¢ cients of the regressors in the …

Ua12/2/1 College Heights Herald, Vol. 84, No. 28, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news. Articles:

• Howerton, Christina. Power Outages Bring Visitors to Bowling Green – Weather, Winter
• Threlkeld, Kohl. Caring in the Cold – William Rummage, Weather
• Burch, Aaron. Bread & Bagel Changes Ownership – Restaurants
• Barczak, Mary. Student Government Association Changes Power – Kayla Shelton, Johnathon Boles
• McCrarey, Magen. Gatton Academy of Math & Science Student Honored – Dalton Hubble
• Erskine, Anne. Editorial Cartoon re: Winter Weather
• Under the Weather: Officials Should Consider Inclement Weather a Threat – Winter, Weather
• Comley, Justin. Western Should Take Preventive Measures – Winter Weather
• White, Lauren. …

The Multinomial Regression Modeling Of The Cause-Of-Death Mortality Of The Oldest Old In The U.S., Dudley L. Poston Jr., Hosik Min

Journal of Modern Applied Statistical Methods

The statistical modeling of the causes of death of the oldest old (persons aged 80 and over) in the U.S. in 2001 was conducted in this article. Data were analyzed using a multinomial logistic regression model (MNLM) because multiple causes of death are coded on death certificates and the codes are nominal. The percentage distribution of the 10 major causes of death among the oldest old was first examined; we next estimated a multinomial logistic regression equation to predict the likelihood of elders dying of one of the causes of death compared to dying of an “other cause.” The independent …

A Poisson-Like Model Of Sub-Clinical Signs From The Examination Of Healthy Aging Subjects, Stephen Merrill, Barbara Myklebust, Joel B. Myklebust, Norman Reynolds, Edmund Duthie

Mathematics, Statistics and Computer Science Faculty Research and Publications

Background and aims: Our studies of the standard neurological examination on 66 middle-aged (50–64 yrs) and elderly subjects (65–84 yrs) demonstrate that healthy elders have neurological deficits (or “signs”) that are not associated with specific known neurological disease. The purpose of the current study is to describe this loss of neurological function in healthy aging subjects as seen through accumulated subclinical neurological signs present.

Methods: Logistic regression is applied to the data on each of six signs. Parameters determined are used to describe the distribution of first occurrence times for each sign. The results are then used to construct a …

Quantitative Literacy On The Web Of Science, 1: The Bibliography And Its Role In The History Of This Journal, H L. Vacher, Todd Chavez

Numeracy

Prior to deciding to propose in 2006 that the National Numeracy Network (NNN) publish a new journal for quantitative literacy with their support, the University of South Florida Libraries investigated the publication environment of the field on the Web of Science®. Reproducing part of that study in this paper, we present findings from topic searches (March 2008) for “numeracy,” “quantitative literacy,” and “statistical literacy.” These updated results include a combined bibliography of 338 peer-reviewed articles amongst 210 different journals, by 748 authors from 321 institutions in 25 countries, in a total of 87 subjects (34% of the subject classes in …

Systematic Reviews Of Animal Experiments Demonstrate Poor Contributions To Human Healthcare, Andrew Knight

Experimentation Collection

Widespread reliance on animal models during preclinical research and toxicity testing assumes their reasonable predictivity for human outcomes. However, of 20 published systematic reviews examining human clinical utility located during a comprehensive literature search, animal models demonstrated significant potential to contribute toward clinical interventions in only two cases, one of which was contentious. Included were experiments expected by ethics committees to lead to medical advances, highly-cited experiments published in major journals, and chimpanzee experiments—the species most generally predictive of human outcomes. Seven additional reviews failed to demonstrate utility in reliably predicting human toxicological outcomes such as carcinogenicity and teratogenicity. Results …

Unlv Magazine, Tony Allen, Afsha Bawany, Barbara Cloud, Holly Ivy De Vore, Gian Galassi, Matthew K. Jacobsen, Michelle Mouton, Erin O'Donnell, Shane Bevell, Cate Weeks

UNLV Magazine

No abstract provided.

Ua35/1 Doers & Deeds Vol. 7, No. 4, Wku Provost

WKU Administration Documents

Newsletter created by the WKU Provost & Vice President of Academic Affairs to highlight the activities of faculty, staff and alumni.

Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao

Theses and Dissertations

This thesis discusses pyridinium bisretinoid compounds (PBRs), which were prepared for two purposes: 1) to use them as standards for detection of novel fluorophores in human RPE cells, which may be involved in age-related macular degeneration (AMD), and 2) to use them in the development of a targeted and triggered drug delivery system for cancer therapy. We prepared a selection of PBRs using a one-pot biomimetic method; synthesis, mechanisms for formation, and characterization of these compounds is described. We also explored the photoreactivity of three novel PBR compounds and found that these PBRs form oxidation products under blue-light irradiation. The …

Ua35/1 Doers & Deeds Vol. 7, No. 3, Wku Provost

WKU Administration Documents

Newsletter created by the WKU Provost & Vice President of Academic Affairs to highlight the activities of faculty, staff and alumni.

Operating Characteristics Of The Dif Mimic Approach Using Jöreskog’S Covariance Matrix With Ml And Wls Estimation For Short Scales, Michaela N. Gelin, Bruno D. Zumbo

Journal of Modern Applied Statistical Methods

Type I error rate of a structural equation modeling (SEM) approach for investigating differential item functioning (DIF) in short scales was studied. Muthén’s SEM model for DIF was examined using a covariance matrix (Jöreskog, 2002). It is conditioned on the latent variable, while testing the effect of the grouping variable over-and-above the underlying latent variable. Thus, it is a multiple-indicators, multiple-causes (MIMIC) DIF model. Type I error rates were determined using data reflective of short scales with ordinal item response formats typically found in the social and behavioral sciences. Results indicate Type I error rates for the DIF MIMIC model, …

Concurrent Panel Session 2: Challenges Facing Our Youth And Aged Populations, Michele Clark, Claudia Collins, Chris Kearney, Ed Jost, Larry Mason, Carla Sloan, William Sullivan

Shaping the Future of Southern Nevada: Economic, Environmental, and Social Sustainability

Moderator: Dr. Ann McDonough, UNLV Gerontology Program Scribe: Lisa Gioia-Acres, UNLV Department of History Conference white paper & Full summary of panel session, 4 pages

Shaping The Future Of Southern Nevada Moderators & Panelists Biographies

Shaping the Future of Southern Nevada: Economic, Environmental, and Social Sustainability

Moderators & Panelists biographies

Shaping The Future Of Southern Nevada Conference Schedule

Shaping the Future of Southern Nevada: Economic, Environmental, and Social Sustainability

Emcee: Dr. Ron Smith, UNLV Interim Vice President for Research & Graduate Dean

Estimating The Effect Of Vigorous Physical Activity On Mortality In The Elderly Based On Realistic Individualized Treatment And Intention-To-Treat Rules, Oliver Bembom, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

The effect of vigorous physical activity on mortality in the elderly is difficult to estimate using conventional approaches to causal inference that define this effect by comparing the mortality risks corresponding to hypothetical scenarios in which all subjects in the target population engage in a given level of vigorous physical activity. A causal effect defined on the basis of such a static treatment intervention can only be identified from observed data if all subjects in the target population have a positive probability of selecting each of the candidate treatment options, an assumption that is highly unrealistic in this case since …

Potret Buram Pelayanan Kesehatan Lanjut Usia Di Indonesia, Indang Trihandini

Kesmas

Jumlah dan proporsi kelompok lanjut usia (lansia) di seluruh dunia, terus meningkat, dan cenderung menjadi masalah kesehatan dan sosial sehingga mendapat perhatian dan dukungan yang serius. Resolusi PBB no 46/ 1991, 16 Desember 1991 menghimbau agar seluruh negara di dunia memberikan hak yang layak kepada kelompok lansia. Di Indonesia, populasi lansia pada tahun 2000 (17,2 juta) meningkat 3 kali lebih besar dari pada tahun 1970 (5,3 juta). Pada tahun 2020, jumlah dan proporsi kelompok lansia di Indonesia diprediksi akan mencapai 28 juta jiwa dan 9,5%. Aspek legal telah menempatkan lansia Indonesia pada tempat yang respek dan terhormat, tetapi, kenyataan memperlihatkan …

Interleukin-6 And Tumor Necrosis Factor-Alpha Values In Elk Neonates, Shannon M. Barber-Meyer, Craig R. Johnson, Michael P. Murtaugh, L. David Mech, P.J. White

United States Department of Agriculture Wildlife Services: Staff Publications

Serological indicators of general condition would be helpful for monitoring or assessing ungulate wildlife. Toward that end, we report the 1st reference values for 2 cytokines, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a), in neonatal elk (Cervus elaphus). We obtained blood samples from 140 calves ≤ 6 days old in Yellowstone National Park during summer 2003–2005. IL-6 values ranged from 0 to 1.21 pg/ml with a median of 0.03 pg/ml. TNF-a values ranged from 0 to 225.43 pg/ml with a median of 1.85 pg/ml. IL-6 and TNF-a concentrations were not significant predictors of elk calf survival through 21 …

Inside Unlv, Diane Russell, Cate Weeks, Shane Bevell, Mamie Peers, Lori Bachand

Inside UNLV

No abstract provided.

Interspecies Comparison Of Pentosidine Accumulation And Its Correlation With Age In Birds, Jesse A. Fallon, Robert L. Cochrane, Brian Dorr, Hillar Klandorf

United States Department of Agriculture Wildlife Services: Staff Publications

Recent studies suggest that a linear correlation exists between the age of individual birds and accumulation of the advanced glycation endproduct pentosidine (Ps). We compared Ps accumulation in skin tissue of Ruffed Grouse (Bonasa umbellus) and Double-crested Cormorants (Phalacrocorax auritus). Skin samples were taken from the breasts of 52 Ruffed Grouse of known ages ranging from a few days to 10 years. Skin was cleaned of feathers and adipose tissue, acid hydrolyzed, and measured for collagen content via hydroxyproline spectrophotometric assay. Pentosidine concentrations were determined using reverse-phase high-performance liquid chromatography. Fluorescent detection (excitation: 310 nm, emission: …

The Antecedents Of M-Commerce Adoption, Morris Kalliny, Michael S. Minor

Business and Information Technology Faculty Research & Creative Works

The growth of Internet shopping has been attributed to rapid advances in technology and other influences such as convenience. We empirically investigate the relationship between demographics, ease of use, convenience, usefulness and enjoyment and intention to use m-commerce and attitude toward m-commerce. Two studies were conducted where a student and a non student sample was used. Data analysis revealed age, gender and educational level of customers do not play a role in influencing intention to use m-commerce. However, convenience, ease of use, usefulness and enjoyment all play a role in the customer's intention to use m-commerce.

Electrochemical Behavior And Determination Of Curcumin, Ping Wu, Wei Chen, Ya-Feng Zhang, Xin-Hua Lin

Journal of Electrochemistry

In 0.1 mol/L phosphate buffer solution (pH 3.0), the voltammetry behaviors of curcumin at a glassy carbon electrode have been studied.One pair of current peaks of the voltammogram may be attributed to a reversible one-electron transfer of curcumin molecules at the glassy carbon electrode.A new method, the differential pulse voltammetry, for curcumin determination is described. The adsorptive potential of curcumin is (+0.8) V(vs. SCE),while its peak potential of curcumin is +0.386V (vs. SCE). The peak current is proportional to the concentration of curcumin over the rage of 1.0×10^-8 mol/L~2.5×10^-7 mol/L. A detection limit of 4.0×10^-9 mol/Lof curcumin …

Inside Unlv, Erin O'Donnell, Diane Russell, Carol C. Harter

Inside UNLV

No abstract provided.

Inside Unlv, Cate Weeks, Carol C. Harter, Holly Ivy De Vore, Gian Galassi, Diane Russell

Inside UNLV

No abstract provided.