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Articles 1621 - 1650 of 58460
Full-Text Articles in Entire DC Network
Stormwater Best Management Practices, Kat Kelleher
Stormwater Best Management Practices, Kat Kelleher
UNH Cooperative Extension
No abstract provided.
Assessing And Understanding Soil Characteristics, Amy Papineau
Assessing And Understanding Soil Characteristics, Amy Papineau
UNH Cooperative Extension
No abstract provided.
Nh State Shoreland Water Quality Protection Act (Landscaping For Water Quality Workshop - 2026), Jay Aube
Nh State Shoreland Water Quality Protection Act (Landscaping For Water Quality Workshop - 2026), Jay Aube
UNH Cooperative Extension
No abstract provided.
Polysemicolon; Novice Programmers And Java Keywords, Briana C. Bettin
Polysemicolon; Novice Programmers And Java Keywords, Briana C. Bettin
Michigan Tech Publications
Most industrial programming languages leverage the English language for reserved keywords – words which a program compiler recognizes as specific execution commands. The divide between expert and novice programmers showcases an intriguing middle-ground by which the polysemy of many keywords becomes revealed. This essay explores a sampling of the multitude of keyword interpretations that a novice programmer may derive from the Java language’s syntactic style and keywords specifically, and how the polysemy of both “English” and “code” meanings to these terms affects the novice-expert programmer transition.The transition from novice to expert, and the mapping of the career of metaphor to …
Real-Time Likelihood Map Generation To Localize Short-Duration Gamma-Ray Transients, Jeremy Buhler, Marion Sudvarg
Real-Time Likelihood Map Generation To Localize Short-Duration Gamma-Ray Transients, Jeremy Buhler, Marion Sudvarg
Computer Science Faculty Research & Creative Works
High-energy transient astrophysical phenomena, such as supernovae and binary neutron star mergers, benefit from a multi-wavelength investigation in which a space- or balloon-based omnidirectional telescope detects and localizes early high-energy emissions (such as a gamma-ray burst), then alerts a narrow-field follow-up instrument to observe the source. The high-energy telescope must provide a map that assigns to each sky location a likelihood that the source appears there. To issue prompt alerts despite limits on communication bandwidth and latency, it is desirable to compute this map aboard the high-energy telescope, but doing so requires rapid response while computing under stringent size, weight, …
Integration Of Islamic Values In Mathematics Learning, Ai Mulya, Surya Faradiba
Integration Of Islamic Values In Mathematics Learning, Ai Mulya, Surya Faradiba
Jurnal Pendidikan Sains
This study aims to identify the integration of Islamic values in mathematics learning and its contribution to student character development. The method used is a systematic literature study by reviewing relevant accredited scientific articles. The results of the study indicate that the integration of Islamic values is carried out through the preparation of Islamic-context-based mathematics problems, linking concepts to verses of the Qur'an and hadith, the application of ethnomathematics with Islamic cultural nuances, and the introduction of Islamic economic concepts. The dominant values that emerge include honesty, responsibility, discipline, justice, and piety. These findings indicate that the integration of Islamic …
Performance Modeling And Improvements On The Grb Source Localization Streaming Pipeline Aboard The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Ye Htet, Ye Htet, Marion Sudvarg, Marion Sudvarg, Honghao Yang, Jeremy Buhler, Roger Chamberlain, Wenlei Chen, Wenlei Chen, James Buckley, Matthew Andrew, Blake Bal, Elisabetta E. Bissaldi, Richard G. Bose, Dana Braun, James H. Buckley, Jeremy Buhler, Eric Burns
Performance Modeling And Improvements On The Grb Source Localization Streaming Pipeline Aboard The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Ye Htet, Ye Htet, Marion Sudvarg, Marion Sudvarg, Honghao Yang, Jeremy Buhler, Roger Chamberlain, Wenlei Chen, Wenlei Chen, James Buckley, Matthew Andrew, Blake Bal, Elisabetta E. Bissaldi, Richard G. Bose, Dana Braun, James H. Buckley, Jeremy Buhler, Eric Burns
Computer Science Faculty Research & Creative Works
The Advanced Particle-astrophysics Telescope (APT) is a mission concept for a space-based gamma-ray telescope whose capabilities include prompt localization of gamma-ray bursts (GRBs) to support multi-wavelength and multi-messenger astrophysics. ADAPT — APT's balloon-borne prototype — can localize GRBs in well under a second using on-board computing hardware. ADAPT will partner with ground-based, fast-slewing optical telescopes, rapidly providing alerts that enable the partner to observe a short-duration burst within a few seconds of detection. In this work, we investigate the utility of having ADAPT issue progressively more accurate location estimates for a GRB as detected Compton events from the burst accumulate …
Instrument Response Functions Of The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Wenlei Chen, James H. Buckley, Marion Sudvarg
Instrument Response Functions Of The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Wenlei Chen, James H. Buckley, Marion Sudvarg
Computer Science Faculty Research & Creative Works
The Antarctic Demonstrator for the Advanced Particle-astrophysics Telescope (ADAPT) gamma-ray/cosmic-ray instrument serves as a precursor to the proposed APT mission. The APT mission is designed to improve sensitivity in the MeV-TeV gamma-ray range by an order of magnitude compared to current missions and is optimized for dark-matter and multimessenger research. The ADAPT instrument uses scintillating fibers for particle tracking and sodium-doped cesium iodide (CsI:Na) tiles read out with wavelength shifting (WLS) fibers for imaging, with solid-state silicon photomultipliers (SiPMs) for calorimetry. It includes four layers of imaging calorimeter detectors and scintillating-fiber trackers, functioning both as a Compton and Pair telescope …
Fpga-Based Data Processing Using High-Level Synthesis On The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Marion Sudvarg, Marion Sudvarg, Longhao Huang, Boran Yang, Blake Bal, Roger Chamberlain, Jeremy Buhler, Leonardo Di Venere, Leonardo Di Venere, Davide Serini, James Buckley, Matthew Andrew, Blake Bal, Elisabetta E. Bissaldi, Richard G. Bose, Dana Braun, James H. Buckley, Jeremy Buhler
Fpga-Based Data Processing Using High-Level Synthesis On The Antarctic Demonstrator For The Advanced Particle-Astrophysics Telescope (Adapt), Marion Sudvarg, Marion Sudvarg, Longhao Huang, Boran Yang, Blake Bal, Roger Chamberlain, Jeremy Buhler, Leonardo Di Venere, Leonardo Di Venere, Davide Serini, James Buckley, Matthew Andrew, Blake Bal, Elisabetta E. Bissaldi, Richard G. Bose, Dana Braun, James H. Buckley, Jeremy Buhler
Computer Science Faculty Research & Creative Works
FPGAs are widely deployed on high-energy astrophysics telescopes to read out sensor data from front-end electronics. To support continuous data streams or high trigger rates, FPGA logic may be employed to process raw sensor readout values, reducing the volume of data transmitted, processed, and stored by downstream CPU-based computational platforms. Across instruments, these FPGA-based processing pipelines often have similar semantics and share common stages. However, diverse telescope designs require unique implementations of the constituent algorithms, and the logic is often rewritten from scratch for a new instrument. Writing, simulating, and debugging firmware is difficult and time consuming. However, High-Level Synthesis …
Panda-Plus: Improved Dataset Of Prostate Whole Slide Images From Panda Challenge With Pixel-Level Expert Annotations, Spencer Hopson, Carson Mildon, Corbyn Kubalek, Joshua L. Ebbert, Ryan Vance, Lauren Laverty, Paul Urie, Dennis Della Corte
Panda-Plus: Improved Dataset Of Prostate Whole Slide Images From Panda Challenge With Pixel-Level Expert Annotations, Spencer Hopson, Carson Mildon, Corbyn Kubalek, Joshua L. Ebbert, Ryan Vance, Lauren Laverty, Paul Urie, Dennis Della Corte
Faculty Publications
Artificial intelligence (AI)-based prostate cancer detection through whole slide images (WSIs) offers promising potential to address the global pathologist shortage while improving clinical consistency. Digital slides and improving image analysis methods encourage the creation of tools to aid in WSI classification. Despite promising advances, these tools are still limited by available training data. Current publicly available datasets, such as Kaggle's PANDA Challenge, while large in scale, rely on slide-level labels that may introduce noise and limit model reliability. Others contain detailed annotations, but are smaller in size due to manual processing efforts. In this work, we introduce PANDA-PLUS, a 546-image …
Hydrothermal Vents In Sulfuric Acid Speleogenesis Karst: Isolated Feeders With Pristine Hypogenic Water Or Interconnected Conduits With Rapid Flow And Recycled Water?, Jakub Mareš, Marek Audy, Serban M. Sarbu, Jan Kukačka, Romeo Eftimi, Jiří Bruthans
Hydrothermal Vents In Sulfuric Acid Speleogenesis Karst: Isolated Feeders With Pristine Hypogenic Water Or Interconnected Conduits With Rapid Flow And Recycled Water?, Jakub Mareš, Marek Audy, Serban M. Sarbu, Jan Kukačka, Romeo Eftimi, Jiří Bruthans
International Journal of Speleology
Underwater connectivity and flow paths in the saturated zone of hypogenic sulfuric acid speleogenesis (SAS) karst remain unclear, despite sustained research over the past 30 years. Being regarded as sources of pristine H2S-charged water, narrow inflow conduits called "feeders" are typically considered primary sources of water and hotspots of speleogenesis. In southeastern Albania, there is a newly discovered active SAS karst system comprising numerous caves and springs. Tracer tests were conducted to investigate the connection of these caves to the surrounding springs and to characterize the flow paths. The results show that water flows from cave lakes to …
Perspectives On Implementing Environmentally Sustainable Practices In Cataract Surgeries: Interviews Of Administrative And Frontline Healthcare Workers, Daniel Parra, Brooke Sherry, Emma Pak, Lauren Taylor, Erin S. Rogers, Sarah E. Hochman, Maria De Los Angeles Ramos Cadena, Joel S. Schuman, Christina R. Prescott, Cassandra L. Thiel
Perspectives On Implementing Environmentally Sustainable Practices In Cataract Surgeries: Interviews Of Administrative And Frontline Healthcare Workers, Daniel Parra, Brooke Sherry, Emma Pak, Lauren Taylor, Erin S. Rogers, Sarah E. Hochman, Maria De Los Angeles Ramos Cadena, Joel S. Schuman, Christina R. Prescott, Cassandra L. Thiel
Wills Eye Hospital Papers
BACKGROUND: Healthcare is responsible for 8.5% of greenhouse gas emission in the United States. Physicians are becoming increasingly concerned about the climate crisis, particularly in the field of ophthalmology where there is a growing body of literature related to sustainability. Although emissions of cataracts surgery, one of the most performed surgical procedures in the world, have been quantified, modifications to practice have yet to be made. This study aims to uplift the perspectives of a diverse set of healthcare workers on implementing environmentally sustainable practices in the cataract surgery setting.
METHODS: 16 semi-structured interviews were conducted with professionals working in …
Comparing The Effectiveness Of Eggshell Spectra From Laser-Induced Break-Down Spectroscopy And Near-Infrared Spectroscopy Using Principal Compo-Nent Analysis To Determine The Authenticity Of Organic Eggs, Ahmad Qusthalani, Rara Mitaphonna, Muliadi Ramli, Rajibussalim Rajibussalim, Kurnia Lahna, Nasrullah Zaini, Nasrullah Idris
Comparing The Effectiveness Of Eggshell Spectra From Laser-Induced Break-Down Spectroscopy And Near-Infrared Spectroscopy Using Principal Compo-Nent Analysis To Determine The Authenticity Of Organic Eggs, Ahmad Qusthalani, Rara Mitaphonna, Muliadi Ramli, Rajibussalim Rajibussalim, Kurnia Lahna, Nasrullah Zaini, Nasrullah Idris
Makara Journal of Science
This study aimed to explore the potential of modern spectroscopy in the authentication of organic and non-organic chicken eggs using near-infrared spectroscopy (NIRS) and laser-induced breakdown spectroscopy (LIBS) spectra. A total of 175 eggs were analyzed, which were grouped into seven categories based on the source of feed given: 100% organic, 100% non-organic, 75% organic, 75% non-organic, 50% organic, free-range chickens, and eggs obtained from the local traditional market. Each group consisted of 25 eggs. NIRS spectra were recorded in the wavelength range of 350–2500 nm, whereas LIBS spectra were recorded in the range of 200–900 nm. A total of …
Hate Speech Detection Using Optimized Feature Representation Via Spiral-Grey Wolf Optimizer-Based Machine Learning Approaches, Noor S. Farhan, Matheel E. Abdulmunim, Hasanen S. Abdullah
Hate Speech Detection Using Optimized Feature Representation Via Spiral-Grey Wolf Optimizer-Based Machine Learning Approaches, Noor S. Farhan, Matheel E. Abdulmunim, Hasanen S. Abdullah
Journal of Soft Computing and Computer Applications
Hate speech detection is crucial as social media diversifies. This research present a lightweight, scalable system using traditional machine learning methods along with a new approach called Spiral-Grey Wolf Optimizer (S-GWO).
S-GWO effectively selects key features that consider both meaning and content from the Term Frequency Inverse Document Frequency (TF-IDF) space, leading to high-quality representation without excessive computing power.
The propoused system was tested on Arabic and another English datasets using six machine learning methods: SVM, RF, LR, KNN, NB, and SGD. It achieved 92% accuracy and F1 score on the Arabic dataset, while reaching 100% accuracy on the English …
Supersaturation Effect And Its Characterization In Gas-Rich Intervals Of Deep Coal Seams, Zhou Lihong, Li Yong, Ding Rong, Li Yun, Li Yongzhou, Kong Jintao
Supersaturation Effect And Its Characterization In Gas-Rich Intervals Of Deep Coal Seams, Zhou Lihong, Li Yong, Ding Rong, Li Yun, Li Yongzhou, Kong Jintao
Coal Geology & Exploration
Objective and Method High free gas content serves as a key factor controlling the enrichment and high productivity of deep coalbed methane (CBM). However, its direct determination is challenging, making the accurate identification of free gas-rich coal seam intervals a core scientific issue for efficient exploration and recovery of CBM. This study investigated the Daning-Jixian block (also referred to as the Daji Block) within the Ordos Basin. Based on analyses and tests of the gas content, coal macrolithotype, physical properties, and log responses of cores collected from representative wells through pressure-retained coring, this study systematically assessed the vertical heterogeneity of …
Research On Pavement Roughness Evaluation Method Based On Smartphones, Siriguleng Bai, Yili Guoqi, A Rong, Guo Guoying, Wang Jing
Research On Pavement Roughness Evaluation Method Based On Smartphones, Siriguleng Bai, Yili Guoqi, A Rong, Guo Guoying, Wang Jing
Journal of China & Foreign Highway
To address the low efficiency and high cost of current detection methods,as well as the insufficient accumulation of pavement damage data on rural low-grade roads,this study developed a vehicle vibration data acquisition application based on smartphones and proposed a conversion method for calculating an index equivalent to the international roughness index (IIRI).Vertical acceleration signals collected during vehicle travel were proposed through high-pass filtering and denoising to calculate the vertical displacement,from which a converted I'IRI was derived.Experimental results show that although the data collected by smartphones has slightly lower accuracy than that collected by professional detection equipment,the proposed I'IRI exhibits a …
Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti
Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti
Makara Journal of Science
Antimalarial drug resistance has encouraged various innovations to develop novel drug compounds that are effective, feasible, and safe, adhering to health standards. One way to do that is by observing and predicting the biological activity of drug compounds using quantitative structure–activity relationship (QSAR) analysis. In this study, QSAR analysis was conducted on the 4-N-(methyl)-4-aminoquinoline derivatives, which effectively inhibit the growth of Plasmodium falciparum as a source of malaria. The research stages involved molecular structure modeling, molecular geometry optimization using the AM1 semi-empirical method, and QSAR descriptor calculations, including electronic (atomic charges (q), HOMO and LUMO energies, polarizability (α), …
Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia
Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia
Makara Journal of Science
Microplastics are a serious global problem that arises worldwide because of their widespread use. Exposure to microplastics can negatively affect human and environmental health. In this study, we used molecular docking methods with MOE software (version 2014.0901) to investigate the interaction between the laccase enzyme and several microplastic compounds as a preliminary study of microplastic degradation using enzymes. The Quantitative Structure Analysis Relationship (QSAR) analysis revealed that all microplastic ligands had higher Pa values than Pi, indicating that the laccase enzyme may be biologically active. The findings of the present study show that polyamide (PA) has the lowest binding energy …
Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin
Enzyme-Free Colorimetric Sensing Of Glucose Using Silver Nanoparticles With A Green Stabilizing Agent From Capsicum Chinense Jacq Extract, Boyfannie Ivan Putra, Hermin Sulistyarti, Muhammad Mashuri Utama, Aura Ananda Haryanto, Rurini Retnowati, Mohamad Rafi, Akhmad Sabarudin
Makara Journal of Science
Diabetes mellitus (DM) is a significant global health issue characterized by abnormal glucose levels in the human body. DM diagnostics are often based on invasive sampling from blood, which poses a potential risk of infection and tissue damage. Therefore, a non-enzymatic and non-invasive method for glucose monitoring is demanded as a simple alternative to glucose detection in urine samples. In this work, enzyme-free glucose determination is based on the formation of silver nanoparticles stabilized by Capsicum chinense Jacq extract (CCJ-AgNPs). Under alkaline conditions, glucose functions as a reducing agent for silver ions, and the extract acts as a stabilizer to …
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
SURE Journal: Science Undergraduate Research Experience Journal
Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.
The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …
Energetics And Kinetics Of Alkali Ion Exchange In Analcime, Jinyi Liu, An T. Ta, R. Seaton Ullberg, Jean Wilfried Hounfodji, Michael Badawi, Hans Conrad Zur Loye, Simon R. Phillpot
Energetics And Kinetics Of Alkali Ion Exchange In Analcime, Jinyi Liu, An T. Ta, R. Seaton Ullberg, Jean Wilfried Hounfodji, Michael Badawi, Hans Conrad Zur Loye, Simon R. Phillpot
Faculty Publications
We employ density functional theory calculations to investigate the energetics and diffusion mechanisms of alkali metal ions (Na+, K+, Rb+, and Cs+) within the analcime framework. While Na+preferentially adsorbs at the center of the 8-member ring, DFT calculations show that larger ions, such as Cs+, occupy the center of the cage due to steric constraints. The computed exchange energies indicate that exchange of Na+by Cs+is thermodynamically favorable. Migration energy barriers, determined using the climbing image nudged elastic band method, show that Na+is …
A Cave In Miocene Conglomerate: The Törökpince-Abaliget Cave System, Hungary, Krisztina Sebe, Piroska Pazonyi, Márton Bauer, Bálint Szappanos, Márton Szabó, Zoltán Szentesi, Mihály Gasparik, Ákos Juhász, Luca Pandolfi, Máté Gregorits, József Haász, Ágnes Novothny, Zsófia Ruszkiczay-Rüdiger
A Cave In Miocene Conglomerate: The Törökpince-Abaliget Cave System, Hungary, Krisztina Sebe, Piroska Pazonyi, Márton Bauer, Bálint Szappanos, Márton Szabó, Zoltán Szentesi, Mihály Gasparik, Ákos Juhász, Luca Pandolfi, Máté Gregorits, József Haász, Ágnes Novothny, Zsófia Ruszkiczay-Rüdiger
International Journal of Speleology
Conglomerate caves are rare, and only a few have been described in the scientific literature. Here, we present a newly discovered and significant cave system in SW Hungary, comprising over 500 m of upper passages and a shorter, lower section of a through-cave developed in Lower–Middle Miocene conglomerates. The formation of these cave passages was controlled chiefly by bedding and fractures. Dissolution has produced typical karstification morphologies, whereas corrasion, granular disintegration, and rock collapse have also played a role in shaping the cave. The cave is dominated by vadose-zone morphologies, but sediment infills indicating upward water flow, along with ceiling …
Structural Framework And Tectonic Implications From Field Investigations In The Ramelau Mountains, Timor-Leste, Tanner A. Nielsen
Structural Framework And Tectonic Implications From Field Investigations In The Ramelau Mountains, Timor-Leste, Tanner A. Nielsen
Theses and Dissertations
Recent advances in petroleum exploration off the southern coast of Timor-Leste and emerging mineral discoveries onshore have underscored the need for a more comprehensive structural understanding of the nation's geology. Although new structural models have been proposed for other parts of Timor, limited progress has been made toward developing detailed models for the Ramelau Mountains, which presents the highest structural relief of the Timor Ranges. Previous mapping in this area has been largely reconnaissance in nature and focused primarily on surface bedrock geology. This study presents a new 1:62,500-scale geologic map and a geometric structural analysis of the Ramelau region …
Gowanus Faces A Hidden Threat Beneath Its Neighborhood Boom, Emma J. Rosenberg
Gowanus Faces A Hidden Threat Beneath Its Neighborhood Boom, Emma J. Rosenberg
Capstones
This article investigates urban redevelopment, climate change and environmental contamination in Brooklyn’s Gowanus neighborhood. The Gowanus Canal itself has been a designated EPA Federal Superfund Site since 2010, this designation does not apply to the land surrounding it where legacy industrial contamination still exists. This includes coal tar from former manufactured gas plants which poses a risk to groundwater and indoor air. Under a 2021 rezoning plan, large-scale residential redevelopment is rapidly moving forward, rising groundwater and increased flooding associated with climate change may exacerbate contaminants. Utilizing agency documents, Community Advisory Group meetings, and conversations with residents, advocates, officials and …
How Has Your Climate Changed?, Rhyannon Bartlett-Imadegawa
How Has Your Climate Changed?, Rhyannon Bartlett-Imadegawa
Capstones
This interactive data visualization shows readers how much the climate has changed in their home state compared to 100 years ago, since the reader was born, the current year and projections into the future. It aims to communicate climate change impacts more personally by linking it to seasons, the reader's birth year and age mile stones and compares a readers' home state to a state that has been more impacted to connect across different states and communities.
Using JavaScript and Svelte, the code calculates and displays seasonal averages for the baseline period for the reader's state and years for the …
Flooding, Not Just A Rain Problem, Annisha Singh
Flooding, Not Just A Rain Problem, Annisha Singh
Capstones
This capstone focuses on the Rockaway Peninsula and how high-tide flooding also known as "sunny-day flooding" is not only affecting Rockaway but neighboring areas, such as Jamaica Bay.
Discovery Of The Multi-Ion Bridge Intermediate: A Computational Exploration Of The Mechanism For Azomethine Ylide Formation From N-Oxides, Martin J. Neal
Discovery Of The Multi-Ion Bridge Intermediate: A Computational Exploration Of The Mechanism For Azomethine Ylide Formation From N-Oxides, Martin J. Neal
Electronic Theses and Dissertations
Density functional theory (DFT) provides a method for calculating the ground-state energies of complex molecular systems through evaluating the electron density instead of the full wave function. When results match either experimental outcomes, calculations with DFT offer a computationally efficient method to help explain chemical phenomena. The transformation of tertiary amine N-oxides to azomethine ylides, a simple route to the precursor for 1,3-dipolar cycloadditions that result in the pyrrolidine scaffolds found in natural products, has received only minimal attention due to concerns that its mechanism includes a highly electrophilic intermediate. Utilizing DFT to model the mechanism of the conversion …
Application Of Polarization Transfer Algorithm In Organic Molecules With Three Nonequivalent Coupled Spins, Dim Safin, Alexander Perepukhov, Sergei Rzhevskiy, Yuri Belousov
Application Of Polarization Transfer Algorithm In Organic Molecules With Three Nonequivalent Coupled Spins, Dim Safin, Alexander Perepukhov, Sergei Rzhevskiy, Yuri Belousov
Turkish Journal of Physics
Polarization transfer between three $1/2$ nuclear spins in a specially prepared isotopically enriched molecule diethylphthalimide malonate-2-$^{13}$C,$^{15}$N molecule was obtained using the nuclear magnetic resonance (NMR) method. The polarization transfer was performed by implementing a sequence of radio frequency pulses and waiting intervals. Relaxation times and NMR spectrum for the studied nuclei were measured in samples of molecules with natural and enriched isotopes $^{13}$C and $^{15}$N. Measurements of the proton relaxation rate for diethylphthalimidomalonate and diethylpthalimidomalonate-2-$^{13}$C,$^{15}$N showed an increase in relaxation rate by a factor of 4 for protons bound to $^{13}$C,$^{15}$N nuclei. The use of the quantum polarization transfer method …
Self-Assembling Rna Nanostructures Are Highly Sensitive To Environmental Conditions, Jordan Aposhian, Surya Pratap S. Deopa, Scott Horowitz, Joseph D. Yesselman
Self-Assembling Rna Nanostructures Are Highly Sensitive To Environmental Conditions, Jordan Aposhian, Surya Pratap S. Deopa, Scott Horowitz, Joseph D. Yesselman
Chemistry and Biochemistry: Faculty Scholarship
Recent developments in RNA nanotechnology have led to an increase in the design of specific, higher-order RNA structures, which will ultimately be used in drug delivery and immunomodulation applications. As researchers create RNA nanostructures with the intention of making them a standard tool in molecular biologists' toolkits, further investigation is required into the robustness of RNA designs. Primarily, in what different molecular contexts are the designed and intended nanostructures stable? In this work, we show that RNA nanostructure self-assembly is highly sensitive to environmental conditions by using second-order right-angle light scattering. While a test RNA hexagonal grid nanostructure forms correctly …
Assessment Of Polymeric Chloroquine Formulations For Targeted Therapy Of Ulcerative Colitis And Metastatic Colorectal Cancer, Neha Kumari
Theses & Dissertations
Effective targeted drug delivery is a critical unmet need in the management of both ulcerative colitis and metastatic colorectal cancer, where conventional systemic therapies may be hindered by suboptimal efficacy and significant side effects. This thesis explores the development and preclinical assessment of polymeric chloroquine (PCQ)-based nanotherapeutics, leveraging stimuli-responsive designs for disease-specific delivery and action.
For ulcerative colitis, a reactive oxygen species (ROS)-responsive nanogel system was engineered to release PCQ, a macromolecular derivative of hydroxychloroquine, specifically in the inflamed areas within the colon. Nanogels with well-defined size and positive surface charge were synthesized via reversible fragmentation chain transfer (RAFT) polymerization …