Digital Commons Network^™

Selective Reversal Of Cu-Amyloid Aggregation Monitored In Real Time By Fluorescence Anisotropy: Ni-Bme-Dach Vs Edta Benchmarks, Alyssa N. Schroeder, Eleanor K. Adams, Dane C. Frost, Erica Lopez, Jennie R. Giacomini, Marilyn R. Mackiewicz

Chemistry Faculty Publications and Presentations

Metal dyshomeostasis, particularly involving Cu2+, is increasingly recognized as a key contributor to amyloid-β (Aβ) aggregation and neurotoxicity in Alzheimer’s disease, motivating the development of chelators capable of selectively disrupting pathogenic metal-Aβ interactions without perturbing essential biological metals. Here, we employ steady-state fluorescence anisotropy as a real-time probe of TAMRA-Aβ1–42 rotational mobility to quantify metal-induced aggregation and its reversibility by two chelators with distinct selectivities: EDTA, a broad-spectrum benchmark, and Ni-bme-dach, a sulfur-rich metallodithiolate with high Cu affinity. Cu2+ induces the most significant increases in anisotropy, consistent with rapid formation of large nanoscale aggregates, while Fe3+ produces moderate aggregation and …

Early Detection Of Infectious Diseases: A Review Of Recent Advances In Pathogen Identification, Molecular Tools, And Metabolomics-Driven Biomarker Discovery, Patrica Ivy Agorsor, Michael O. Eze

Chemistry Faculty Research & Creative Works

The recent COVID-19 pandemic has heightened public interest in noninvasive methods for early diagnosis of infectious diseases. In addition, various government agencies have implemented "infectious disease preparedness" to mitigate future outbreaks. This review highlights conventional and advanced methods for infectious disease diagnosis with an emphasis on emerging mass spectrometry methods. Conventional methods for pathogen identification, such as culture-based techniques and molecular methods, have limitations with respect to sensitivity, specificity, and turnaround time. Recent advances in high-resolution mass spectrometry have revolutionized the field of infectious disease biomarker discovery. These techniques enable the comprehensive profiling of metabolites in various biological samples, identification …

Statistical Guarantees Of Deep Generative Models Involving Diverse Spaces: Generation Consistency And Robustness, Anish Chakrabarty

Doctoral Theses

Generative modeling focuses on the task of producing new data samples that closely resemble those drawn from an original, unknown distribution. Despite being well-known in statistical estimation theory, the approach has gained substantial traction in recent years, driven by groundbreaking results in areas such as image synthesis, natural language generation, and network modeling. The complexity of modern-era data domains and the ensuing adaptations that suitable models must undergo have presented new challenges. These advances raise several fundamental questions, the first of which is: When do generative models accurately approximate the true data distribution? One may also ask: How well do …

On Robust Estimation Of Multivariate Location And Scale With Applications, Soumya Chakraborty

Doctoral Theses

The principal objective of this thesis is, in a nutshell, to provide robust estimators of multivariate location and scale which have reasonable to high model efficiency but avoid high computational complexity so as to be practically useful in real problems. We utilize the minimum density power divergence (DPD) and the related philosophy to invoke robustness. There are some computational issues while minimizing the DPD in different multivariate set-ups. We will work on this problem rigorously and come up with three types of estimation procedures which are explicitly or implicitly related to the minimum DPD methodology, keeping the computational issue in …

Time And Water, Sheila Nayar

Journal of Religion & Film

This is a film review of Time and Water (2026), directed by Sara Dosa.

Developing Deep Neural Network Based Brain Computational Models From Psychophysics Data Of Some Simple Perceptual Phenomena: Visual As Well As Auditory, Chandran Keerthi S

Doctoral Theses

The thesis, consisting of nine chapters, explores the methodology of building testable brain computational models using Deep Neural Networks (DNN), which are trained by psychophysics data. Psychophysics is the quantitative study of perception of physical stimuli. In psychophysics experiments, one or more parameters associated with the stimuli are changed, and the human subject’s responses to the stimuli are recorded. This thesis encompasses both experimental psychophysics works, as well as computational models of the phenomena involved. The contributory chapters of the thesis start in Chapter 2 with the perspective building of the novel methodology followed throughout this research involving psychophysics on …

Response To Agency Comments Re: Comment Letter For The 2023 Butte Priority Soils Operable Unit (Bpsou) Groundwater Compliance Evaluation (Dated March 10, 2025) Received May 7, 2025, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

On The Misattribution Of Reassurance: A Structural Account, Griselda Poe

Publications and Research

This paper challenges the conventional assumption that empathy generates reassurance in interpersonal services. Reassurance is treated not as an emotion transmitted from the outside, but as an internal state transition that arises when a fixed and erroneous world model—a False Fantasy—undergoes collapse and the world becomes computable again. The study identifies a systematic misattribution pattern where providers and receivers treat empathy as a causal mechanism rather than a post hoc explanatory label. By introducing Base AI as an external reference—a system capable of providing structural information without emotional modulation—this paper demonstrates that reassurance is generated through operations such as distraction …

Search For Low-Mass Electron-Recoil Dark Matter Using A Single-Charge Sensitive Supercdms-Hvev Detector, M. F. Albakry, I. Alkhatib, D. Alonso-González, J. Anczarski, T. Aralis, T. Aramaki, I. Ataeelangroudy, C. Bathurst, R. Bhattacharyya, A. J. Biffl, P. L. Brink, M. Buchanan, R. Bunker, B. Cabrera, R. Calkins, R. A. Cameron, C. Cartaro, D. G. Cerdeño, Y. Y. Chang, M. Chaudhuri, J. H. Chen, R. Chen, N. Chott, J. Cooley, H. Coombes, P. Cushman, R. Cyna, S. Das

All Works

We present constraints on low-mass dark matter electron scattering and absorption interactions using a SuperCDMS high-voltage eV-resolution (HVeV) detector. Data were taken underground in the NEXUS facility located at Fermilab with an overburden of 225 meters of water equivalent. The experiment benefits from the minimizing of luminescence from the printed circuit boards in the detector holder used in all previous HVeV studies. A blind analysis of 6.1 g·days of exposure produces exclusion limits for dark matter-electron scattering cross sections for masses as low as 1 MeV/c², as well as on the photon-dark photon mixing parameter and the coupling …

Exploring Enacted Active Learning Practices In Postsecondary Chemistry Lecture And Laboratory Courses, Kendall M. Zammit

USF Tampa Graduate Theses and Dissertations

The work in this thesis begins to explore the enacted active learning practices in postsecondary chemistry lecture and laboratory courses. Chapter 1 explores the level of inquiry in postsecondary laboratories. Chapter 2 explores instructional and assessment practices at two-year institutions.

Chemistry postsecondary laboratories offer a unique opportunity to engage students in inquiry-based instruction. Inquiry-based instruction was categorized by the asking faculty members at four-institutions about six characteristics of laboratory design: choosing a problem, background research, designing procedures, analyzing data, communicating results, and interpreting results. As students have the freedom to make decisions on more characteristics of inquiry learning, the closer …

Corrigendum To “Interim Rationalizable Implementation Of Functions” (Kunimoto T, Saran R, Serrano R (2024) Mathematics Of Operations Research 49(3):1791–1824), Takashi Kunimoto, Rene Saran, Roberto Serrano

Research Collection School Of Economics

This is the brief corrigendum to “Interim rationalizable implementation of functions” [Kunimoto T, Saran R, Serrano R (2024) Interim rationalizable implementation of functions. Math. Oper Res. 49(3):1791–1824].

Communication As Layered Architecture: Core Processing And Empathic Modulation, Griselda Poe

Publications and Research

This paper proposes a structural re-description of communication by separating Core processing from its social interface. Using the developmental sequence of Large Language Models (LLMs) as an external reference point, a layered architecture is identified, consisting of a foundational Core processing layer and a subsequent Empathic modulation layer.

The investigation begins with the observation that empathic signaling can obstruct rather than facilitate interaction for certain individuals. By examining the emergence of Base AI—Core processing prior to empathic adjustment—it is demonstrated that coherent, constraint-preserving interaction is possible without affective resonance.

Through this framework, existing cognitive theories and observed "deficits" are repositioned. …

Impact Of Iron-Bearing Fillers On The Mechanical Strength And Chemical Stability Of Magnesium Potassium Phosphate Matrices Incorporating Rhenium, Sergey Sayenko, Volodymyr Shkuropatenko, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Petra Ecorchard, Natalija Murafa, Iva Milisavljevic, Scott T. Misture

Faculty Publications

We report on the study of the immobilization process of non-radioactive rhenium (Re), a chemical analogue of technetium-99 (⁹⁹Tc), in compounds based on magnesium potassium phosphate (MKP), as well as the possibility of enhancing their properties with iron-bearing additives/fillers. Powdered Re2O7 was used as the initial Re-containing source. Because of the solubility and high leachability of Tc (VII), which is also volatile at high temperatures, its immobilization for long-term storage and disposal poses a serious challenge to researchers. Taking this into account, low-temperature stabilization technology based on MKP, a cementitious material, is currently considered promising. We prepared experimental …

A Note On Sufficient Dimension Folding For Regression Mean Function With Categorical Predictors, Bilin Zeng, Akim Adekpedjou, Xuerong Meggie Wen

Mathematics and Statistics Faculty Research & Creative Works

Multi-dimensional arrays are referred to as tensors. Tensor-valued predictors are commonly encountered in modern biomedical applications, such as electroencephalogram (EEG), magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion-weighted MRI, and longitudinal health data. In survival analysis, it is both important and challenging to integrate clinically relevant information, such as gender, age, and disease state along with medical imaging tensor data or longitudinal health data to predict disease outcomes. Most existing higher-order sufficient dimension reduction regressions for matrix- or array-valued data focus solely on tensor data, often neglecting established clinical covariates that are readily available and known to have predictive value. …

Majority Of Utahns Support Keeping Bears Ears National Monument As Originally Designated, Michaelann Nelson

Utah People and Environment Poll (UPEP)

Bears Ears National Monument in Southeastern Utah was established in 2016 by President Obama after a coalition of Native American petitioned for its designation. In 2017, during his first administration, President Trump reduced the size of the monument by 85%. It was subsequently restored to the original boundaries in 2021 by President Biden. In 2022, the Utah Legislature provided $5 million in funding for the Attorney General’s office to challenge the Bears Ears National Monument designation, and the State of Utah filed a lawsuit in August 2022 challenging the designation (1).

Responsible Ai In Teaching And Learning, Asa B. Stone, Mark C. Stone, Derek M. Heeren, Santosh Pitla

PRAIRIE: Pioneering Responsible AI for Research, Innovation, and Education

The rapid adoption of generative artificial intelligence (AI) in higher education presents both transformative opportunities and significant pedagogical risks. While AI tools are becoming embedded in academic and professional environments, their integration into teaching and learning raises critical questions about cognitive engagement, academic integrity, equity, and skill development. This white paper proposes a principled framework for the responsible integration of AI in higher education, grounded in the dual commitment to AI literacy and the cultivation of durable skills.

The framework articulates six core principles: purposefulness; transparency; integrity and attribution; critical AI literacy; equity and access; and privacy and data protection. …

Future Trends In Cybersecurity: A Meta-Review, Yara Mohammed, Manar Alsaid, Gahangir Hossain

Faculty Publications

The increasing importance of cybersecurity in protecting digital assets, data and infrastructures necessitates a reevaluation of research priorities within the discipline. As of today, numerous emerging cybersecurity topics are gaining significant importance in both academic research and industry applications. To identify recent trends in cybersecurity topics, this study extracts scholarly articles from two prestigious academic databases, the ACM Digital Library, and Google Scholar, covering the period from early 2015 to late 2024.Through a systematic identification of trends and focal points in cybersecurity research, a comprehensive analysis is facilitated, including Latent Dirichlet Allocation (LDA), Biterm Topic Modeling (BTM), keyword frequencies, and …

Fortifying The Seams Between C/C++ And Rust: Characterizing Bugs In Interop Tools, Xuemeng Cai, Jiakun Liu, Cunyang Liu, Lingfeng Bao, Yijun Yu, Lingxiao Jiang

Research Collection School Of Computing and Information Systems

Rust has become increasingly popular in recent years due to its safety and high performance. Despite these advantages, Rust projects rarely start from scratch in practice, and many Rust-based systems instead use hybrid programming, where Rust interoperates with existing C/C++ code. To reduce the manual effort involved in this interoperation (interop) process, several interop tools have been proposed to facilitate hybrid programming between Rust and C/C++. However, the challenges and limitations of these tools remain largely unexplored, leaving developers unclear about the future directions and users unclear about the appropriate usage scenarios. To fill the gap, we mined 320 bugs …

Grounding Is All You Need? Dual Temporal Grounding For Video Dialog, You Qin, Wei Ji, Xinze Lan, Hao Fei, Xun Yang, Dan Guo, Roger Zimmermann, Lizi Liao

Research Collection School Of Computing and Information Systems

In the realm of video dialog response generation, capturing both the essence of video content and the temporal nuances of conversation history is crucial. While some approaches rely on large-scale pretrained visual-language models, often neglecting temporal dynamics, others emphasize spatial-temporal relationships within videos but demand intricate object trajectory pre-extractions and overlook dialog temporal dynamics. This paper introduces the Dual Temporal Grounding-enhanced Video Dialog model (DTGVD), designed to bridge the gap between these two approaches. DTGVD uniquely integrates the strengths of both by emphasizing dual temporal relationships. It achieves this by predicting dialog turn-specific temporal regions, selectively filtering video content, and …

Obstructive Sleep Apnea Prediction: A Comprehensive Review And Comparative Study, Thi Khanh Chi Huynh, Amonae Dabbs-Brown, Anna Jurek-Loughrey, James Mulhall, Tuan Dung Pham, Ngoc Phu Doan, Viet Hung Tran, Zichi Zhang, Xuan Hoang Nguyen, Yimeng An, Peixin Li, Phi Hung Nguyen, Thi Linh Hoang, Xinming Shi, Hans Vandierendonck, Sebastien Bailly, Jean-Louis Pépin, Thai Son Mai

Research Collection School Of Computing and Information Systems

Obstructive Sleep Apnea (OSA) is a highly prevalent sleep disorder linked to considerable public health burdens and comorbidities. However, its heterogeneous presentation and the limited accessibility of traditional diagnostic tools such as polysomnography (PSG) lead to widespread underdiagnosis. As a result, artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL) models, have attracted attention as an alternative pathway to detection. This paper first provides a comprehensive review of AI-driven OSA diagnosis, covering different diagnosis problems, input-data types, data biases, pre-processing techniques, and model performance. We then leverage the largest clinical dataset used in OSA prediction to date, …

The Case For Ai Authorship In Copyright Law, Cheng Lim Saw, Duncan Lim

Research Collection Yong Pung How School Of Law

Today, with generative AI, literary and artistic works can be created almost effortlessly. There is at present intense debate as to whether works generated by AI – broadly categorised as “AI-assisted” and “AI-generated” works – ought to attract copyright protection. AI-assisted works are those that involve some degree of human intervention. Where AI-generated works are concerned, however, such works are created autonomously by the AI itself with minimal (de minimis) input from an identifiable human being. Presently, it is generally accepted that AI-generated works do not attract copyright protection for want of a human author. This article examines whether it …

Learnable Game-Theoretic Policy Optimization For Data-Centric Self-Explanation Rationalization, Yunxiao Zhao, Zhiqiang Wang, Xingtong Yu, Xiaoli Li, Jiye Liang, Ru Li

Research Collection School Of Computing and Information Systems

Rationalization, a data-centric framework, aims to build self-explanatory models to explain the prediction outcome by generating a subset of human-intelligible pieces of the input data. It involves a cooperative game model where a generator generates the most human-intelligible parts of the input (i.e., rationales), followed by a predictor that makes predictions based on these generated rationales. Conventional rationalization methods typically impose constraints via regularization terms to calibrate or penalize undesired generation. However, these methods are suffering from a problem called mode collapse, in which the predictor produces correct predictions yet the generator consistently outputs rationales with collapsed patterns. Moreover, existing …

The Gains Do Not Make Up For The Losses: A Comprehensive Evaluation For Safety Alignment Of Large Language Models Via Machine Unlearning, Weixiang Zhao, Yulin Hu, Xingyu Sui, Zhuojun Li, Yang Deng, Yanyan Zhao, Bing Qin, Wanxiang Che

Research Collection School Of Computing and Information Systems

Machine Unlearning (MU) has emerged as a promising technique for aligning large language models (LLMs) with safety requirements to steer them forgetting specific harmful contents. Despite the significant progress in previous studies, we argue that the current evaluation criteria, which solely focus on safety evaluation, are actually impractical and biased, leading to concerns about the true effectiveness of MU techniques. To address this, we propose to comprehensively evaluate LLMs after MU from three aspects: safety, over-safety, and general utility. Specifically, a novel benchmark MuBench with 18 related datasets is first constructed, where the safety is measured with both vanilla harmful …

Less Is More: Docstring Compression In Code Generation, Guang Yang, Yu Zhou, Wei Cheng, Xiangyu Zhang, Xiang Chen, Terry Yue Zhuo, Xin Zhou, Ke Liu, David Lo, Taolue Chen

Research Collection School Of Computing and Information Systems

The widespread use of Large Language Models (LLMs) in software engineering has intensified the need for improved model and resource efficiency. In particular, for neural code generation, LLMs are used to translate function/method signature and DocString to executable code. DocStrings, which capture user requirements for the code and are typically used as the prompt for LLMs, often contain redundant information. Recent advancements in prompt compression have shown promising results in Natural Language Processing (NLP), but their applicability to code generation remains uncertain. Our empirical study shows that the state-ofthe-art prompt compression methods achieve only about 10% reduction, as further reductions …

Quantum Chebyshev Transform-Based Graph Neural Networks For Financial Fraud Detection, Minrui Xu, Bingyan Guan, Bethel Hui Ting Loke, Paul R. Griffin

Research Collection School Of Computing and Information Systems

Financial fraud detection is a critical challenge requiring accurate identification of anomalous patterns in complex transaction networks. Graph Neural Networks (GNNs) have emerged as powerful tools for fraud detection by capturing relational structures among entities. Meanwhile, quantum computing offers new possibilities to enhance machine learning through high-dimensional Hilbert spaces and parallelism. In this paper, we propose a hybrid classical-quantum model called QCTGNN (Quantum Chebyshev Transform-based Graph Neural Network) for financial fraud detection. The QCTGNN integrates a classical graph neural network component based on Simplified Graph Convolutions (SGConv) with a quantum component that performs a Chebyshev polynomial-based transform via variational quantum …

Derivation Of An Updated Brief Multivariable Prediction Model To Detect Panic-Related Anxiety In Emergency Department Patients With Cardiopulmonary Complaints, Sharon C. Sung, Felicia J. L. Ang, Arul Earnest, Leslie E. C. Lim, Shreshtha Jolly, Gilaine Rui Ng, A. John Rush, Marcus E. H. Ong

Research Collection School of Social Sciences

Background Patients with panic related-anxiety (i.e., panic attacks or panic disorder) frequently present to emergency departments (EDs) with cardiopulmonary complaints but are often undiagnosed, which can lead to recurrent visits and prolonged distress. This study aimed to derive a new symptom-based multivariable diagnostic prediction model to detect panic-related anxiety in ED patients with cardiopulmonary symptoms.Methods We conducted a single-blind prospective derivation study over 15 months in the ED of a major tertiary hospital in Singapore. Patients presenting with symptoms of palpitations, chest pain, dizziness, or difficulty breathing were assessed using the Structured Clinical Interview for DSM Disorders (SCID) to diagnose …

New Asymptotics Applied To Functional Coefficient Regression And Climate Sensitivity Analysis, Qiying Wang, Peter C. B. Phillips, Ying Wang

Research Collection School Of Economics

A general asymptotic theory is established for sample cross moments of nonstationary time series, allowing for long-range dependence and local unit roots. The theory provides a substantial extension of earlier results on nonparametric regression that include near-cointegrated nonparametric regression as well as spurious nonparametric regression. Many new models are covered by the limit theory, among which are functional coefficient regressions in which both regressors and the functional covariate are nonstationary. Simulations show finite sample performance matching well with the asymptotic theory and having broad relevance to applications, while revealing how dual nonstationarity in regressors and covariates raises sensitivity to bandwidth …

Deep Learning Style Transfer For Enhanced Smoke Plume Visibility: A Standardized False Color Composite (Sfcc) In Gems Satellite Imagery, Yemin Jeong, Seung Hee Kim, Menas Kafatos, Jeong-Ah Yu, Kyoung-Hee Sung, Seung-Yeon Kim, Goo Kim, Jae-Jin Kim, Yangwon Lee

Institute for ECHO Articles and Research

Wildfire smoke visualization using geostationary satellite imagery is essential for real-time monitoring and atmospheric analysis; however, inconsistencies in color tone across Geostationary Environment Monitoring Spectrometer (GEMS) images hinder reliable interpretation and model training. This study proposes a Standardized False Color Composite (SFCC) framework based on deep learning style transfer to enhance the visual consistency and interpretability of wildfire smoke scenes. Four tone-standardization methods were compared: the statistical Empirical Cumulative Distribution Function (ECDF) correction and three neural approaches—ReHistoGAN, StyTr2, and Style Injection Diffusion Model (SI-DM). Each model was evaluated visually and quantitatively using six metrics (SSIM, LPIPS, FID, histogram similarity, ArtFID, …

How Consistent Friendlike Conversation With Ai Companions Influences Our Attitudes And Perceptions Toward Ai: An Exploratory Experiment, Qi Hui Jerlyn Ho, Meilan Hu, Adalia Yin Hui Goh, Emma Jane Pragasam, Andree Hartanto

Research Collection School of Social Sciences

Despite skepticism and distrust in artificial intelligence (AI), it is increasingly integrated into daily life, with its potential benefits drawing interest. Yet little is known about the attitudinal and psychological effects of human–AI interactions, and whether consistent interactions with AI chatbots can change users’ attitudes and perceptions. Our within-subjects experiment (N = 52) investigated how five days of socially oriented, friendlike interactions with an AI chatbot, versus a journaling control, influenced changes in attitudes and perceptions of AI. Participants’ attitudes towards AI, trust, perceived empathy, anthropomorphism, animacy, likeability, perceived intelligence and safety, dependency, and exploratory well-being indicators were recorded. Results …

Final 2022 Unreclaimed Sites Sampling: Ur-22 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.