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Diamond Open Access Journals In India: Status, Sustainability And Challenges, Mallikarjun Dora, Kanagasabai K, Raj Kishor Kampa Jun 2026

Diamond Open Access Journals In India: Status, Sustainability And Challenges, Mallikarjun Dora, Kanagasabai K, Raj Kishor Kampa

FORCE 2026

Open-access publishing has transformed scholarly communication in recent decades. The share of OA articles between 2014 and 2024 increased by 26%, from a modest 14% in 2014 to 40% in 2024. OA journals have evolved over time and exist in various models based on funding mechanisms, including the Gold, Green, Hybrid, and Diamond models. While OA publishing emerged in response to scientific inequality, middle- and low-income countries face the barrier of high Article Processing Charges (APC), which hinder them from publishing in those journals (Alperin, 2022). The Article Processing Charges are part of the Gold and Hybrid OA models, where …


Using Ai-Assisted Programming To Develop Research Services Tools For Research Impact, Open Access Publishing & More, Gary Lee Jun 2026

Using Ai-Assisted Programming To Develop Research Services Tools For Research Impact, Open Access Publishing & More, Gary Lee

FORCE 2026

Academic libraries play a vital role in scholarly communication, As research practices become more data‑driven and interdisciplinary, librarians can help scholars by creating and sharing flexible, customizable tools that align with local workflows and user needs.

AI Assisted programming (sometimes called “vibe coding”) offers a new way for librarians without extensive programming knowledge to develop such tools . This allows previously non-expert librarians to go from conceptual goals to working applications by rapid prototyping, experimentation, and roll-out, resulting in service innovation and improvement.

This presentation illustrates how librarians at HKUST have explored vibe coding with tools like GROK, POE, and …


[2026 Honorable Mention] Chumash Heritage National Marine Sanctuary, Daylyn R. Reese Jun 2026

[2026 Honorable Mention] Chumash Heritage National Marine Sanctuary, Daylyn R. Reese

Ethnic Studies Research Paper Award

This research offers unique insights into the creation and development of the Chumash Heritage National Marine Sanctuary (N.M.S.) with a focus on indigenous populations’ roles (primarily Chumash and Costanoan). In this episode, I analyze what makes this NMS different from every NMS precluding it, how it recognizes a new goal in conservation (thrivability), and the areas in which improvements still must be made to authentically include and honor indigenous voices.


Fabrication Of Two-Dimensional Optoelectrical Devices, Holly Walworth Jun 2026

Fabrication Of Two-Dimensional Optoelectrical Devices, Holly Walworth

Honors Projects

Optoelectrical devices enable the exploration of interesting quantum states observed in two-dimensional (2D) condensed material systems. 2D materials, such as graphene and transition metal dichalcogenides, exhibit unique electronic properties, including the Fractional Quantum Anomalous Hall effect (FQAHE). The realization of the FQAHE offers a pathway toward topological quantum computing via non-Abelian anyons. Still, fabricating high-quality 2D optoelectrical devices remains a significant experimental challenge. Using mechanical exfoliation and stacking techniques within an inert argon environment, we attempted to fabricate optoelectrical devices using twisted molybdenum ditelluride (tMoTe2) and gallium telluride (GaTe). Three devices were successfully assembled; however, structural defects including hexagonal boron …


The Architecture Of Chemical Understanding: How Representation Selection, Ordering, And Feature Salience Shape Students' Conceptions In Chemistry, Isaiah Nelsen Jun 2026

The Architecture Of Chemical Understanding: How Representation Selection, Ordering, And Feature Salience Shape Students' Conceptions In Chemistry, Isaiah Nelsen

USF Tampa Graduate Theses and Dissertations

Chemical representations play a central role in how students learn and reason aboutchemistry. While representations are routinely used in chemistry classrooms, students often struggle to extract relevant information, connect representations to underlying chemical principles, and apply this information to problem-solving. This dissertation investigates the role of representations in supporting students’ conceptual understanding and reasoning across general and organic chemistry through three qualitative studies.

The first study in this work explores how variation in chemical representation influences how students understand foundational chemistry principles. This study sought to characterize how second semester general chemistry students approach dipole–dipole interaction tasks with four distinct …


Recognizing And Rewarding Peer Review: Rethinking Research Assessment For Openness, Fairness, And Global Equity, Tung Tung Chan, Bernd Pulverer, Johan Rooryck Jun 2026

Recognizing And Rewarding Peer Review: Rethinking Research Assessment For Openness, Fairness, And Global Equity, Tung Tung Chan, Bernd Pulverer, Johan Rooryck

FORCE 2026

The Coalition for Advancing Research Assessment (CoARA) Working Group on Recognizing and Rewarding Peer Review has developed a comprehensive framework for reforming how scholarly review is valued within research careers. Our recommendations address a fundamental question: how can peer review, a critical yet often invisible scholarly contribution, be made visible, credited, and meaningfully integrated into research assessment?

Developed through a collaborative effort across 16 European organisations, the Working Group’s outputs offer targeted recommendations for four key stakeholder groups: research performing organizations, research funding bodies, publishers and editors, and individual researchers. These recommendations are structured across five key dimensions:
(1) Openness: …


Mimic: A Multimodal Dataset For Affective Incongruity In Video, Ethan M. Baird Jun 2026

Mimic: A Multimodal Dataset For Affective Incongruity In Video, Ethan M. Baird

Computer Science Senior Theses

This thesis investigates the computational challenges of constructing a database for affective incongruity, exploring the difficulties in automating the collection of contradictory affective states. Capturing these incongruities is essential for advancing Vision-Language Models (VLMs) and sentiment analysis, which struggle to interpret signals deviating from basic emotional archetypes. Curating non-congruent affect provides the data necessary for models to navigate complex social contexts, which is critical for applications like automated Audio Description (AD) for the visually impaired and nuanced Human-Computer Interaction (HCI). To capture these signals, two distinct methodologies were employed. The first utilized a tripartite decomposition of video data, isolating textual, …


Llzk-Symex: Building A Circuit Verification Framework For The Llzk Zero-Knowledge Intermediate Language, Nicolás Iair Schaievitch Jun 2026

Llzk-Symex: Building A Circuit Verification Framework For The Llzk Zero-Knowledge Intermediate Language, Nicolás Iair Schaievitch

Computer Science Senior Theses

The rising adoption of ZK (Zero-Knowledge) technology has led to a plethora of DSLs (Domain Specific Languages) for facilitating the development of ZK circuits. At the same time, there has also been an increase in the number of compilation targets for these languages, with different cryptographic foundations and performance optimizations. LLZK, by Veridise, aims to unify the ecosystem by providing a single IR (Intermediate Representation) for the different frontend DSLs, that would then also allow choosing between different backends. Given the high stakes (particularly financial) that a lot of ZK circuits are under, together with their high level of complexity, …


Capturing Large Language Model Similarity Through Spectral Analysis, Ishan Verma Prasad Jun 2026

Capturing Large Language Model Similarity Through Spectral Analysis, Ishan Verma Prasad

Computer Science Senior Theses

With the rapid development of open-sourced models on Huggingface, there is a strong need for a way to systematically determine the similarity between models. More strongly, for intellectual property and organization, we need a way to determine the "lineage" of models. We borrow principles from Heavy-Tailed Self-Regularization and Random Matrix Theory to provide an inference-free method to accomplish this. We cluster a corpus of several model families by their spectral fingerprints and demonstrate that each model family occupies a distinct region in weight space. This confirms prior ideas of training setups leaving artifacts on model weights and allows us to …


Reliability-Aware Mixture-Of-Agents For Robust Ai-Generated Image Detection, Jake Jump, Yu-Wing Tai Jun 2026

Reliability-Aware Mixture-Of-Agents For Robust Ai-Generated Image Detection, Jake Jump, Yu-Wing Tai

Computer Science Senior Theses

Detecting AI-generated images requires reasoning across multiple levels of evidence, ranging from low-level statistical artifacts to high-level semantic inconsistencies. Existing approaches typically rely on a single class of signals or emphasize complex multi-agent coordination, which limits robustness under distribution shifts and common image degradations. We propose a reliability-aware Mixture-of-Agents (MoA) framework that treats Vision-Language Model (VLM) agents and computational features as complementary experts and aggregates their predictions based on empirically calibrated reliability. Rather than relying on intricate inter-agent reasoning, our approach centers on structured aggregation: high-precision “anchor” agents drive predictions, while weaker but complementary signals are adaptively incorporated to resolve …


Rscore - A Tool For Learning And Quantifying Software Infrastructure Resiliency, Selena Yujia Zhou Jun 2026

Rscore - A Tool For Learning And Quantifying Software Infrastructure Resiliency, Selena Yujia Zhou

Computer Science Senior Theses

As LLMs take over writing code, infrastructure resilience has become the central challenge of software development, especially for gaming applications, where latency, availability, and scale demands are extreme. However, holistic software infrastructure is difficult to understand for casual developers because of the multiple layers of abstraction that make up an application, and the lack of structured information from proprietary companies. This thesis explores the creation of rscore, a tool that quantifies software infrastructure resiliency and subsequently educates developers about the architecture of any existing gaming application. The tool generates two graphical models of a game’s early versus current infrastructure and …


Holistic Strategies For Optimizing Municipal It Operations And Cost Efficiency, Joseph Yazdanpanahi Jun 2026

Holistic Strategies For Optimizing Municipal It Operations And Cost Efficiency, Joseph Yazdanpanahi

Certified Public Manager® Applied Research

Municipalities work to deliver secure and impactful IT (information technology) services while often working within tight budget constraints. To address this problem, this article offers an experience-based and comprehensive framework to optimize municipal IT operations. It emphasizes leveraging automation, streamlining hardware and software management, and forging strategic partnerships to drive cost savings and efficiency gains. Designed to equip municipal IT leaders with practical tools and insights, this article aims to help modernize IT processes.


Decoding Stock Market Movements: The Role Of Unemployment And Volatility, Bipllab Roy, Suparna Bhattacharjee Jun 2026

Decoding Stock Market Movements: The Role Of Unemployment And Volatility, Bipllab Roy, Suparna Bhattacharjee

Northeast Journal of Complex Systems (NEJCS)

This study investigates how unemployment and market volatility interact with stock prices in the Indian context, framing the stock–labour–volatility nexus as a complex adaptive system (CAS) rather than a set of linear, time-invariant relationships. Using verified secondary data on unemployment, India VIX, and NSE stock indices for 2013–2023, we first apply simple and multiple regression as a descriptive baseline. Results show a strong negative association between unemployment and stock prices (R ≈ 0.824, R² ≈ 0.68, p < 0.05), consistent with Keynesian demand-side channels, while the linear VIX–stock relationship is weak and statistically insignificant (R² ≈ 0.07, p > 0.05), consistent with the expectation that volatility operates through non-linear, regime-dependent mechanisms not captured by OLS.

Importantly, we document and transparently disclose critical …


Fairness-Aware And Efficient Federated Learning Frameworks For Heterogeneous Systems, Simin Javaherian Jun 2026

Fairness-Aware And Efficient Federated Learning Frameworks For Heterogeneous Systems, Simin Javaherian

Doctoral Dissertations

Federated Learning (FL) enables decentralized clients to collaboratively train machine learning models without sharing raw data, making it a promising paradigm for privacy-preserving intelligence across large-scale, heterogeneous systems. However, practical FL environments face significant challenges arising from variations in client resources, participation patterns, client behavior, and data distributions. These challenges often lead to inefficiency, unbalanced contributions, and unfairness, ultimately degrading model performance and discouraging long-term client participation. This dissertation advances the state of FL by developing a unified suite of fairness-aware and efficiency-driven frameworks tailored for heterogeneous environments. We investigate fairness from multiple perspectives, including client selection, contribution weighting, and …


The Interplay Of Seasonality, Evolution, And Density-Dependence In Discrete-Time Predator-Prey Dynamics, Narendra Pant Jun 2026

The Interplay Of Seasonality, Evolution, And Density-Dependence In Discrete-Time Predator-Prey Dynamics, Narendra Pant

Doctoral Dissertations

We extend the discrete-time mathematical models developed in (Ackleh et al., 2019) and (Ackleh et al., 2024) to account for seasonal prey reproduction and build a class of discrete-time predator-prey seasonal models. Each model distinguishes between breeding and non-breeding seasons, representing prey reproduction as a periodic function of period 2. Altogether, three different models are analyzed. In the first part, we extend the predator-prey model from (Ackleh et al., 2019) to incorporate seasonality. We study the resulting dynamics and show that when the inherent reproduction number of the prey and the invasion reproduction number of the predator are larger than …


Disparities In The Identification Of Vulnerable Communities Due To Design Storm Methods: A Case Study In The Vermilion River Watershed, South Louisiana, Usa, Claire Orgeron Jun 2026

Disparities In The Identification Of Vulnerable Communities Due To Design Storm Methods: A Case Study In The Vermilion River Watershed, South Louisiana, Usa, Claire Orgeron

Masters Theses

Accurately identifying socially vulnerable populations at-risk of flooding is critical for equitable disaster mitigation and planning. This study investigates how the selection of design storm method, which is fundamental to developing flood risk maps used for this identification, influences which socially vulnerable populations are recognized as being at elevated flood risk. The most widely used design storm approach relies on National Oceanic and Atmospheric Administration (NOAA) Atlas 14 point-based rainfall frequency estimates. These estimates are typically applied spatially using areal reduction factors, thereby disregarding rainfall spatial variability in real storms. Stochastic Storm Transposition (SST), an alternative design storm approach that …


Scientific Crosstalk: Natural Language Processing, Praveshika Bhandari Jun 2026

Scientific Crosstalk: Natural Language Processing, Praveshika Bhandari

Theses and Dissertations

While sentiment analysis has made significant strides in domains such as social media and personal correspondence, its application to formal scientific writings remains under-explored. The crosstalk between emotional expressions in personal and professional communications has also received limited attention despite its potential to reveal insights into the emotional drivers of scientific creativity. Our research introduces a computational framework designed to detect and quantify emotional expressions across various documents over time. Leveraging state-of-the-art transformer models fine-tuned on domain-specific corpora, the framework models emotional tone distribution. Integrating emotion analysis with knowledge graph modeling enables the exploration of emotional trends alongside key scientific …


Generating Live Heatmaps Of Edr Data Through A Spatiotemporal Weighting, Joel T. Williams, C. Sean Bohun, Alberto Fornaci, Michael R. Lindstrom Jun 2026

Generating Live Heatmaps Of Edr Data Through A Spatiotemporal Weighting, Joel T. Williams, C. Sean Bohun, Alberto Fornaci, Michael R. Lindstrom

School of Mathematical & Statistical Sciences Faculty Publications

This paper introduces a novel method for generating live heatmaps of eddy dissipation rate (EDR) data through a spatiotemporal weighting designed to enhance turbulence visualization in aviation. As more flight data become available, approaches relying solely on in-flight EDR measurements have the potential to accurately nowcast and visualize turbulence with low computational cost. The proposed method significantly improves the turbulence visualization capabilities of common commercial aircraft. This is particularly valuable for pilot decision-making and trip planning, enhancing flight safety and operational efficiency. This approach also incorporates an innovative uncertainty threshold, which refrains from predicting when there are insufficient data, thereby …


Public Acceptance Of Meat-Reduction Policies Across Cultures: Comparing Singapore And Switzerland, Bianca Wassmann, Shu Tian Ng, Mark Chong, Angela K. Y. Leung, Michael Siegrist Jun 2026

Public Acceptance Of Meat-Reduction Policies Across Cultures: Comparing Singapore And Switzerland, Bianca Wassmann, Shu Tian Ng, Mark Chong, Angela K. Y. Leung, Michael Siegrist

Research Collection Lee Kong Chian School Of Business

Purpose – As meat-reduction policies are discussed across the globe, many are met with public resistance. Cultural values may help explain this pushback, yet their role in shaping support for food policy remains poorly understood. This study is the first to apply cultural cognition theory to food policy by examining how cultural worldviews shape the acceptance of meat-reduction interventions in Singapore and Switzerland—two economically developed countries with contrasting cultural profiles. Design/methodology/approach – In an online survey, participants (Singapore: n = 357; Switzerland: n = 495) rated their acceptance of 11 meat-reduction interventions (e.g. taxes, subsidies, labelling). We then analysed to …


Deployment-Aware Deep Learning For Computer Vision: Efficient Architectures From 3d Segmentation To Mixed Reality, Bahar Uddin Mahmud Jun 2026

Deployment-Aware Deep Learning For Computer Vision: Efficient Architectures From 3d Segmentation To Mixed Reality, Bahar Uddin Mahmud

Dissertations

Deep learning has become the dominant approach for solving vision-centric problems; however, its successful deployment in real-world applications remains limited by high computational cost, data dependency, and insufficient integration with practical and human-centered environments. While state-of-the art deep learning models often achieve impressive performance in controlled settings, they frequently fail to generalize or operate efficiently under deployment constraints such as limited resources, complex data modalities, and real-time interaction requirements. These limitations motivate the need for a deployment-oriented deep learning framework that balances accuracy, efficiency, and practical usability.

This dissertation investigates the design and deployment of efficient deep learning architectures for …


Breadquest: Enhancing Roguelike Accessibility Through Procedural Generation And Thematic Design, Hahns Pena Jun 2026

Breadquest: Enhancing Roguelike Accessibility Through Procedural Generation And Thematic Design, Hahns Pena

Computer Science and Software Engineering

BreadQuest is a top-down roguelike dungeon crawler with a whimsical dessert theme that aims to make the genre more accessible while preserving strategic depth and replayability. Players explore procedurally generated dungeons, fight pastry-themed enemies, and collect bakery-inspired items that support a flavor-elemental combat system, with each run offering unique layouts, encounters, and rewards. Built in Unity with a modular, data-driven architecture, the game uses procedural generation techniques like Binary Space Partitioning, Voronoi diagrams, and Perlin noise to create varied and replayable levels. The project emphasizes approachable gameplay, cultural dessert inspiration, and replayability, with success evaluated through playtesting and player feedback.


Real-Time Simulation Of Bio-Luminescent Light Propagation Using Compute Shaders Within Unreal Engine, Jaden D. Halevi Jun 2026

Real-Time Simulation Of Bio-Luminescent Light Propagation Using Compute Shaders Within Unreal Engine, Jaden D. Halevi

Computer Science Senior Theses

Presented in this paper is a GPU-native approach to interactive fluid simulation within Unreal Engine 5. The system, BioFluidSim, implements an incompressible Navier-Stokes solver using Unreal’s Niagara Grid2D compute shader pipeline, with a modular biological emission output stage parameterized from experimentally measured Lingulodinium polyedrum bioluminescence behavior. The system is evaluated against FluidNinja Live, a commercially available fragment shader fluid implementation, as a performance baseline. Beyond performance, BioFluidSim offers greater physical fidelity than the fragment shader baseline. Helmholtz–Hodge pressure projection enforces a divergence-free velocity field at runtime, a physical constraint approximated but not enforced by fragment shader approaches. The biological emission …


A Systematic Review Of Intrusion Detection Systems For Internet Of Medical Things: Performance, Efficiency, Explainability, And Generalization, Oswald Adohinzin, Youssef Harrath Jun 2026

A Systematic Review Of Intrusion Detection Systems For Internet Of Medical Things: Performance, Efficiency, Explainability, And Generalization, Oswald Adohinzin, Youssef Harrath

Research & Publications

The Internet of Medical Things (IoMT) has transformed health care delivery through medical devices, remote patient monitoring, and real-time clinical decision support. However, the proliferation of IoMT devices introduces security vulnerabilities that put patient safety and data privacy at risk. Intrusion Detection Systems (IDS) have emerged as essential components for protecting IoMT networks from cyberattacks. This article presents a systematic review of IoMT-IDS research, analyzing 53 high-quality papers published between 2020 and 2025, identified through database searches spanning 2016–2025 across IEEE Xplore, Springer, ScienceDirect, and ACM Digital Library. We organize the literature through a comprehensive taxonomy spanning classical machine learning …


Exploring Regenerative Vegetable Systems On The Central Coast Of California, Una S. O'Connell Jun 2026

Exploring Regenerative Vegetable Systems On The Central Coast Of California, Una S. O'Connell

Master's Theses

As climate change and current agricultural practices place pressure on the long term sustainability and resilience of food production systems, there is growing interest in whether existing agricultural systems can adapt to maintain productivity while improving environmental outcomes.

This study evaluated the effects of regenerative versus standard organic vegetable production systems on yield, insect communities, and weed suppression across three field trials conducted on California's Central Coast. In addition, I collected baseline soil health data for all trials. Trials 1 and 2 were carried out at the Cal Poly San Luis Obispo Organic Farm using cabbage and broccoli as cash …


Improving The Reliability And Performance Of A Supersonic Indraft Tube Wind Tunnel, Christian J. Kaml Jun 2026

Improving The Reliability And Performance Of A Supersonic Indraft Tube Wind Tunnel, Christian J. Kaml

Master's Theses

Access to supersonic testing is increasing in demand, and wind tunnels remain one of the safest and most cost-effective methods for gathering high-speed flow data. Despite being more economical than alternative options, supersonic wind tunnel facilities often require substantial investment to construct, operate, and maintain.

The novel indraft tube tunnel architecture was conceived as a high-speed flow testbed that incorporates features of both Ludwieg tubes and indraft wind tunnels to maintain costs low enough to be accessible even to small universities. This design was first developed and tested in 2018 at California Polytechnic State University, featuring a cost per test …


Updates To The Caniform Fauna (Carnivora, Caniformia) Of The John Day Formation, Oregon, Usa, John D. Orcutt, Kevin C. Talbott, Michael J. Monroe, Nicholas A. Famoso Jun 2026

Updates To The Caniform Fauna (Carnivora, Caniformia) Of The John Day Formation, Oregon, Usa, John D. Orcutt, Kevin C. Talbott, Michael J. Monroe, Nicholas A. Famoso

Biology Faculty Scholarship

The John Day Formation of central Oregon preserves a diversity of Oligo-Miocene caniform carnivorans, many of which were first described from the formation. However, many historically important specimens lack detailed locality or stratigraphic information, complicating any analysis of faunal change through time. Here, we describe 16 new specimens of caniforms from the John Day Formation, most with precise stratigraphic information. We report multiple specimens of the amphicyonids Daphoenus Leidy, 1853, Paradaphoenus cuspigerus (Cope, 1878), and Temnocyon altigenis (Cope, 1878), all previously known from the formation. We also report the first definitive occurrence of the hesperocyonine canid Osbornodon Wang, 1994 from …


Ms110 Syllabus: Introduction To Computers, Information Systems, And Artificial Intelligence, Wei Zhang Jun 2026

Ms110 Syllabus: Introduction To Computers, Information Systems, And Artificial Intelligence, Wei Zhang

Management Science and Information Systems Faculty Publication Series

This is a syllabus for Professor Wei Zhang's MS110: Introduction to Computers, Information Systems and Artificial Intelligence Course within UMass Boston's College of Management. This is an Open Educational Resource and can be remixed, copied, redistributed, altered and reused as long as permission is given to the original creator.


Shared Language For Responsible Ai Integration, Asa B. Stone, Mark C. Stone, Alisha Bevins, Jean Claude Niyomugabo, Irene Magara, Jacob Abaare, Derek M. Heeren, Mubarak Abu Zouriq Jun 2026

Shared Language For Responsible Ai Integration, Asa B. Stone, Mark C. Stone, Alisha Bevins, Jean Claude Niyomugabo, Irene Magara, Jacob Abaare, Derek M. Heeren, Mubarak Abu Zouriq

PRAIRIE: Pioneering Responsible AI for Research, Innovation, and Education

As AI rapidly reshapes how we work and learn, employers increasingly seek graduates who can think before they prompt, exercising judgment under pressure rather than merely producing output. Yet students are praised for AI use in one course and penalized for it in the next, and faculty are left to lead responsibly on shifting ground, with no shared language to guide them.

This paper introduces the PRAIRIE Framework for AI Integration, a shift from reactive gatekeeping toward proactive stewardship. It emerged from a qualitative sentiment analysis of three communities (students, faculty, and industry partners) whose concerns converged on one need: …


Identifying Textual Predictors Of Early Termination In Clinical Trials In Medicine: An Explainable Machine-Learning Study, Rohan Ramnarain Jun 2026

Identifying Textual Predictors Of Early Termination In Clinical Trials In Medicine: An Explainable Machine-Learning Study, Rohan Ramnarain

Dissertations, Theses, and Capstone Projects

About one in five clinical trials in medicine ends early, wasting valuable resources and reducing the evidence available for developing life-saving medical treatments. This project uses a method called Trial2Vec, which is a self-supervised machine-learning method that converts clinical trial documents into dense numerical representations that capture their key design and clinical characteristics, to turn each proposed clinical trial’s written protocol into a compact numerical profile (a process referred to as embedding). These profiles are then paired with a predictive machine learning models to identify the words and phrases in the trial documents that can signal a higher risk of …


Investigation Of Warfarin–Human Serum Albumin Binding By Ultrafast Affinity Extraction Using Single- And Dual-Column Affinity Microcolumn Systems, Samiul Alim Jun 2026

Investigation Of Warfarin–Human Serum Albumin Binding By Ultrafast Affinity Extraction Using Single- And Dual-Column Affinity Microcolumn Systems, Samiul Alim

Department of Chemistry: Dissertations, Theses, and Student Research

This dissertation examined the interaction of warfarin with human serum albumin (HSA) by using affinity chromatography, with particular emphasis on ultrafast affinity extraction (UAE) and affinity microcolumns. HSA affinity supports were prepared by immobilizing HSA onto diol-bonded silica via Schiff base chemistry and used to prepare affinity microcolumns for chromatographic studies under physiological-like conditions at pH 7.4 and 37.0 °C. UAE studies were performed to investigate the effects of residence time, flow rate, and column configuration on the measured apparent free fraction of warfarin and on the calculated apparent binding parameters. The results showed that the measured apparent free fraction …