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Articles 1771 - 1800 of 69605
Full-Text Articles in Entire DC Network
Summary Of Beaver And Iron Counties’ Water Conservation And Provisioning Strategies, Lisa Welsh, Joanna Endter-Wada, Burdette Barker, Bethany Neilson, Anna Mcentire, Melissa Stamp, Brian Steed
Summary Of Beaver And Iron Counties’ Water Conservation And Provisioning Strategies, Lisa Welsh, Joanna Endter-Wada, Burdette Barker, Bethany Neilson, Anna Mcentire, Melissa Stamp, Brian Steed
Reports
This report focuses on water conservation and provisioning strategies that both Beaver and Iron Counties are pursuing to help meet their citizens’ current and future water needs and to contribute to statewide water conservation efforts. It primarily relies on publicly available data from state, county, conservancy district, and city databases, plans, and documents. The purposes of this document are to provide regional context for understanding water use in Beaver and Iron Counties and to describe water conservation strategies that can influence the trajectories of their future water use.
In both Beaver and Iron Counties, agriculture remains the primary user of …
Considerations For Assigned Water After Expiration Of The 2007 Guidelines, Kathryn Sorensen, Sarah Porter, Anne Castle, John Fleck, Eric Kuhn, Jack Schmidt, Katherine Tara
Considerations For Assigned Water After Expiration Of The 2007 Guidelines, Kathryn Sorensen, Sarah Porter, Anne Castle, John Fleck, Eric Kuhn, Jack Schmidt, Katherine Tara
The Traveling Wilburys of the Colorado River
As Colorado River supplies and demands reach razor-thin margins, new tools to provide adaptive capacity will play a critical role in sustaining communities across the West. We must reduce our consumption of water, while finding ways to cushion the impact. One of the most innovative tools for doing this, developed over the last two decades, is “Assigned Water” - giving users the ability to store conserved water earmarked for their own future use. Originally developed as “Intentionally Created Surplus” in the 2007 Colorado River Interim Guidelines, Assigned Water has been revised and expanded through U.S. Mexico Treaty Minutes and as …
Image-Derived 3d Hepatic Lobule Modeling Of Acetaminophen-Induced Hepatotoxicity, Rebecca Lauren Strauss
Image-Derived 3d Hepatic Lobule Modeling Of Acetaminophen-Induced Hepatotoxicity, Rebecca Lauren Strauss
Selected Full-Text Master Theses 2021-
The liver’s highly structured vascular microarchitecture governs blood perfusion, metabolic zonation, and the spatial distribution of xenobiotic toxicity. Current computational models of hepatic drug metabolism often oversimplify this geometry, limiting their ability to capture realistic flow dynamics and cellular injury patterns. This study develops a multiscale computational framework to predict acetaminophen-induced hepatotoxicity using image-derived, three-dimensional hepatic lobule geometries. The model integrates computational fluid dynamics (CFD) with a mechanistic cellular injury module to simulate the interplay between perfusion, metabolism, and hepatocellular viability.
Realistic vascular reconstruction was achieved from histopathology liver slices, and the resulting geometry was meshed and solved using ANSYS …
Deep Learning For Eeg-Based Emotion Recognition With Temporal And Spectral Interpretability, Shruti Rameshbhai Shingala
Deep Learning For Eeg-Based Emotion Recognition With Temporal And Spectral Interpretability, Shruti Rameshbhai Shingala
Selected Full-Text Master Theses 2021-
Electroencephalography (EEG)-based emotion recognition has emerged as a critical component of affective computing and clinical neuroscience. Existing approaches to this problem primarily reduce the multi-dimensional EEG time series to a single averaged feature vector, thereby discarding the temporal structure of the emotional response. The present work addresses three identified gaps in the literature: the absence of temporal interpretability, the uniform use of frequency bands, and the use of single-scale temporal feature extraction. A deep learning architecture, MST-Mamba-Asym, is proposed, comprising four components: Asymmetry Attention, which encodes hemispheric asymmetry by computing signed left–right channel differences, FreqBandAttention, which learns differential weights across …
Large Language Model Communication And Data Transfer Across A Simulated Telephone Line, Jared Reyes
Large Language Model Communication And Data Transfer Across A Simulated Telephone Line, Jared Reyes
Dissertations and Theses
This thesis presents a proof-of-concept communication system in which two local large language model endpoints communicate across a simulated analog telephone line using legacy USB modems. The project combines modem voice mode, modem data mode, local speech processing, and structured machine messaging into a single staged session. During the voice phase, one endpoint places a call, the other answers, speech generated by a locally hosted LLaMA-family model is synthesized with Piper, transmitted through the modem voice path, captured on the remote side, and transcribed with Faster-Whisper to drive the next response. After the voice exchange, the system transitions to a …
Rethinking Climate Change Education: Wyoming And New Jersey As Effective Models Of Climate Change In Education Standards, Jamie W. Miller
Rethinking Climate Change Education: Wyoming And New Jersey As Effective Models Of Climate Change In Education Standards, Jamie W. Miller
Pitzer Senior Theses
Education is an essential and oft-overlooked part of the conversation about climate change. As I’ll demonstrate in this thesis, education shapes how the public understands climate change and creates environmental knowledge, attitudes, behaviors, and intentions. Exploring and understanding climate change education allows us to understand how people form perspectives about climate issues. This topic is extremely important, but one we often gloss over when thinking about climate solutions. I analyzed three case studies of educational standards in the United States to understand how political context, writing focuses, and benchmarks impact the efficacy of climate change standards. My research found that …
How Candidates Campaign To Sway Minority Voter Bases, Katelyn Karwick
How Candidates Campaign To Sway Minority Voter Bases, Katelyn Karwick
Senior Honors Theses and Projects
Religious groups in the United States are making large partisan switches–decades-long Democrats are questioning their support and often change their vote to another party. This phenomenon contributed to Michigan’s flip to Republican in the 2024 presidential election, as well as divided Jewish support for New York City mayoral candidate Zohran Mamdani. Past research has linked a positive correlation between religious participation and political mobilization, though the tactics used by campaigners to create this connection have gone under research. Looking at Donald Trump’s victory in Dearborn, Michigan in 2024 and Zohran Mamdani’s extensive New York City mayoral campaign, this study focuses …
From Wikipedia Tables To Public Data Visualizations, Tanvir Prince
From Wikipedia Tables To Public Data Visualizations, Tanvir Prince
Open Educational Resources
This open educational resource presents a practical mathematics lesson in which students turn numerical data from Wikipedia into a clear data visualization. Students select a Wikipedia page with a data table but little or no visual representation. They examine the original source, date, units, definitions, and possible data limits. They then organize the data in Microsoft Excel or another spreadsheet, choose an appropriate chart, and explain what the visualization helps readers understand. A complete worked example uses the 2017 population growth rates of South American countries.
The resource package includes an instructor lesson plan, a student project guide, a Wikimedia …
Iron(Ii)/Cobalt(Ii)-Mediated Silicon And Carbon Quantum Dots For Nanozyme Activity And Fluorescence Sensing Of Hydrogen Peroxide And Glucose, Kang Qin
Dissertations and Theses
Silicon quantum dots (SiQDs) and carbon quantum dots (CQDs) have been widely studied as fluorescent nanomaterials for sensing applications. In this thesis, we developed two different nanomaterials, SiQDs and CQDs, and investigated their catalytic activities and applied them for the detection of hydrogen peroxide and glucose. In the first project, Co2+-mediated SiQDs were synthesized through a hydrothermal method. The obtained nanoparticles showed obvious peroxidase-like activity toward the oxidation of tetramethylbenzidine (TMB) in the presence of H2O2 under acidic conditions. Moreover, a weak oxidation of TMB was also observed without H2O2, suggesting the existence of oxidase-like activity. To better understand the …
Fourier Pseudospectral Methods For The Variable-Order Space Fractional Wave Equations, Yanzhi Zhang, Xiaofei Zhao, Shiping Zhou
Fourier Pseudospectral Methods For The Variable-Order Space Fractional Wave Equations, Yanzhi Zhang, Xiaofei Zhao, Shiping Zhou
Mathematics and Statistics Faculty Research & Creative Works
In this paper, we propose Fourier pseudospectral methods to solve the variable-order space fractional wave equation and develop an accelerated matrix-free approach for its effective implementation. In constant-order cases, fast algorithms can be designed via the fast Fourier transforms (FFTs), and the computational cost at each time step is O(NlogN) with N the total number of spatial points. In variable-order cases, however, the spatial dependence in the power s(x) leads to the failure of inverse FFTs. While the direct matrix-vector multiplication approach becomes impractical due to excessive memory requirements. Hence, we propose an accelerated matrix-free approach for effective implementation in …
Big Tech As Transnational Spyware Regulator, Natalie R. Davidson
Big Tech As Transnational Spyware Regulator, Natalie R. Davidson
Fordham Intellectual Property, Media and Entertainment Law Journal
Spyware has emerged as a potent tool for leaders to shrink dem- ocratic contestation. In response to calls for constraints on the trade in spyware, states have updated the principal multilateral agree- ment on export controls, civil society groups have employed strate- gic litigation, and the European Union has altered its regulation, in each case with the aim of limiting exports where there is a risk of human rights violations. Yet, scandals involving the Israeli company NSO, among others, have made clear that even the updated regula- tory landscape is inadequate. Many actors are currently debating the reasons for existing …
Monomeric And Dimeric Metal Complexes Of A New Tridentate Azole-Isoindoline-Urea Ligand, Ben Hudak
Monomeric And Dimeric Metal Complexes Of A New Tridentate Azole-Isoindoline-Urea Ligand, Ben Hudak
Williams Honors College, Honors Research Projects
1,3-Diiminoisoindoline (DII) compounds have been found to be novel materials for both metal binding and chromophore applications. In this work, I am investigating the next synthetic step in developing pyrazole- and indazole-DII compounds. These compounds stem from the reaction of the unsubstituted imine of the pyrazole- or indazole-DII adduct with an isocyanate. These DII compounds, DII-pyrazolePhNCO, DII-pyrazolenapthylNCO, DII-indazolePhNCO, DII-indazolenapthylNCO, DII-pyrazoleptolylNCO, and DII-indazoleptolylNCO were prepared using ethanol as the solvent and heat. Metal acetates were then reacted with the ligands using DMF and heat. The acetate salts included copper (II) and nickel(II). Some distinctive hydrogen bonding interactions were observed in the …
Ransomware As Organization: A Comparative Analysis Of Corporate And Criminal Structures In Conti, George Urling
Ransomware As Organization: A Comparative Analysis Of Corporate And Criminal Structures In Conti, George Urling
Theses, Dissertations and Capstones
Cybercriminal groups continue to pose major threats to global cybersecurity. One of the most common types of cybercriminal groups are, “Ransomware-as-a-Service (RaaS)" groups, who create and sell ransomware. While research is conducted into the development of ransomware, there is limited reporting on the organizational structure and habits of RaaS groups. In 2022, prominent RaaS group Conti had their chat logs leaked, with the logs ranging from 2020 to 2022. This study seeks to provide a deeper understanding of RaaS group structures by utilizing the Conti leaked logs as a case study. The study, entitled “Ransomware as Organization: A Comparative Analysis …
A Macrocognitive Design Taxonomy For Simulation-Based Training Systems: Bridging Cognitive Theory And Human-Computer Interaction, Jessica M. Johnson
A Macrocognitive Design Taxonomy For Simulation-Based Training Systems: Bridging Cognitive Theory And Human-Computer Interaction, Jessica M. Johnson
Virginia Digital Maritime Center (VDMC) Faculty Publications
Simulation-based training systems are increasingly deployed to prepare learners for complex, safety-critical, and dynamic work environments. While advances in computing have enabled immersive and data-rich simulations, many systems remain optimized for procedural accuracy and surface-level task performance rather than the macrocognitive processes that underpin adaptive expertise. Macrocognition encompasses higher-order cognitive processes that are essential for performance transfer beyond controlled training conditions. When these processes are insufficiently supported, training systems risk fostering brittle strategies and negative training effects. This paper introduces a macrocognitive design taxonomy for simulation-based training systems derived from a large-scale meta-analysis examining the transfer of macrocognitive skills from …
Microwave Synthesis And Characterization Of Fe2ptge Nanoparticles, Ally T. Fennell, David Carnevale
Microwave Synthesis And Characterization Of Fe2ptge Nanoparticles, Ally T. Fennell, David Carnevale
Chemistry Theses
Magnetic, semiconductor, and spintronic materials are vital to the functionality of devices from household appliances and sensors to medical and computing systems. This study discusses a novel synthesis and characterization of nanoscale Fe₂PtGe nanoparticles. The material was synthesized using microwave irradiation (175oC, 5 minutes) and characterized using XRD, XRF, TEM, and VSM. XRD of the synthesized particles correlates to a cubic crystal structured, indicating a face-centered cubic (fcc) platinum structure with iron and germanium incorporated in a disordered manner. XRF confirms the presence and relative ratios of iron, platinum, and germanium species. TEM imagery shows spherical nanoparticles with an average …
Computational Clinical Judgment: Predicting Risk With Large Language Models, Hannah Laqueur, Ryan W. Copus
Computational Clinical Judgment: Predicting Risk With Large Language Models, Hannah Laqueur, Ryan W. Copus
Faculty Works
For seventy years, research has shown actuarial methods outperform clinical judgment. Yet actuarial approaches have limitations: they generally rely on structured data; cannot exploit rare case-specific details; have limited accuracy where outcome data are scarce or incomplete; and cannot offer case-level justifications. Large language models (LLMs) offer a different approach. Like actuarial methods, they aggregate information algorithmically, but like clinicians, they bring general knowledge and can provide case-level justifications. We prompted seven LLMs to assess rearrest risk from 113 parole hearing transcripts and compared their predictions to a machine learning model trained on 4,000 cases with 91 administrative variables. GPT-5 …
Closing The Loop In Sustainable Fashion: Recycling Textile Waste And Its Environmental, Social, And Consumer Impacts, Anthony Amotoe-Bondzie
Closing The Loop In Sustainable Fashion: Recycling Textile Waste And Its Environmental, Social, And Consumer Impacts, Anthony Amotoe-Bondzie
Sustainability Program Posters and Papers
Fast fashion has intensified textile waste, emissions, and social inequities across global supply chains. This study examines sustainable fashion frameworks and the role of textile recycling in advancing circularity. It employes a qualitative integrative literature review synthesizing interdisciplinary research on waste streams, recycling technologies, policy instruments, and consumer behavior. However, advanced recycling technologies offer environmental benefits but remain limited in scale. Nonetheless, rising consumption offsets efficiency gains, while economic and behavioral barriers hinder systemic change. Technological innovation alone is insufficient; circular design, regulatory enforcement, and reduced overproduction are essential for sustainable transformation.
Frequency Stabilization Of An Affordable Adjustable Repetition Rate Dual Frequency Comb Spectrometer, Michael Moran
Frequency Stabilization Of An Affordable Adjustable Repetition Rate Dual Frequency Comb Spectrometer, Michael Moran
Physics, Astronomy and Geophysics Honors Papers
Two affordably home-built optical frequency combs are stabilized for use in molecular spectroscopy. Each comb is paired with a multi-tiered stabilization scheme that will enable the dual-comb spectrometer to perform precision measurements. The two degrees of freedom for an optical frequency comb, the repetition rate frequency and offset frequency, are accounted for in this stabilization scheme. The repetition rate is directly stabilized through control of the laser enclosure temperature and the fiber laser cavity length. The offset frequency is controlled indirectly via the stabilization of an optical beat note, the heterodyned signal resulting from a narrow linewidth laser and the …
Community Science For Enigmatic Ecosystems: Using Ebird To Assess Avian Biodiversity On Glaciers And Snowfields, William E. Brooks, Jordan Boersma, Neil Paprocki, Peter Wimberger, Scott Hotaling
Community Science For Enigmatic Ecosystems: Using Ebird To Assess Avian Biodiversity On Glaciers And Snowfields, William E. Brooks, Jordan Boersma, Neil Paprocki, Peter Wimberger, Scott Hotaling
Watershed Sciences Faculty Publications
Mountain glaciers and snowfields are rapidly receding because of climate warming. Species living in these habitats remain poorly studied, likely because of the remoteness and ruggedness of their terrain. We leveraged community science data from eBird—an online database of bird observations from around the world—to characterize bird use of mountain glaciers and snowfields. We estimated total bird biodiversity and preference for glaciers and snowfields over nearby, ice-adjacent habitats. We used field notes from eBird users and breeding codes to extend our data set to include insight into habitat usage and behavior. Finally, we compared our community-science approach to previous studies …
Ai In The Workplace: Understanding Role Ambiguity, Employee Motivation, And Learning Engagement, Sheena Leah Metzger
Ai In The Workplace: Understanding Role Ambiguity, Employee Motivation, And Learning Engagement, Sheena Leah Metzger
Theses, Dissertations and Capstones
The rapid integration of artificial intelligence (AI) into organizational processes has altered how work is performed and experienced by employees, yet empirical research examining the human implications of AI-driven change remains limited. This study examined the perceived impact of AI implementation on role ambiguity, employee motivation, and training engagement, and investigated the moderating role of perceived organizational support (POS). Grounded in Job Demands–Resources (JD-R) Theory and Organizational Support Theory (OST), the research examined how employees interpreted and responded to AI-related changes in their work environment.
The results offer valuable insights into a shifting perception of how employees experience technology in …
Handwriting Recognition In Vr, Dominique Mosley
Handwriting Recognition In Vr, Dominique Mosley
EWU Masters Thesis Collection
Virtual Reality (VR) is slowly becoming more popular for more than just entertainment. VR can be found in educational, office, and even healthcare settings to help discover more intuitive ways to teach, collaborate, and treat patients. Outside of the virtual world, these environments typically rely on writing for communicating or note-taking. Currently, VR input forces users to rely on clunky on-screen keyboards which disrupts the user’s immersion and breaks the flow of natural interaction. This thesis explores the potential of VR as a learning platform by combining it with artificial intelligence (AI). It aims to develop a VR-enhanced handwriting practicing …
Assessing Forest Health And Small Mammals After A Limited Suppression Wildfire In Colville National Forest, Samantha J. Kennel
Assessing Forest Health And Small Mammals After A Limited Suppression Wildfire In Colville National Forest, Samantha J. Kennel
EWU Masters Thesis Collection
In the face of a wildfire crisis, there is a growing need to expand the pace and scale of forest treatments, including the strategic use of wildfire as a management tool. However, ecological outcomes remain uncertain in forests shaped by more than a century of fire suppression. The 2022 Thor Fire, a managed wildfire in the Colville National Forest, Washington, provides an opportunity to evaluate forest health in a relatively understudied system. Using a control–impact design, I established 100 monitoring plots in burned and adjacent unburned forests to assess how wildfire and fire severity influence forest structure, fuels, and tree …
Legal Ethics Of Ai Snake Oil: Navigating The Hype, Harm, And Hope Of Legal Ai, Drew Simshaw
Legal Ethics Of Ai Snake Oil: Navigating The Hype, Harm, And Hope Of Legal Ai, Drew Simshaw
Scholarly Works
This paper argues that the legal ethics of AI extend far beyond competence and hallucinations. It shows how AI often functions as a mirror, exposing deeper ethical questions about institutional incentives, lawyer wellbeing, access to justice, and AI's broader social and environmental impacts.
Cross-Temporal Statistical Approaches For Evaluating Predictor-Outcome Relationships, Jeff Joseph
Cross-Temporal Statistical Approaches For Evaluating Predictor-Outcome Relationships, Jeff Joseph
Dartmouth College Ph.D Dissertations
Central auditory function is linked with cognitive deficits, but few research projects use existing statistical approaches or develop new ones to forecast cognitive deficits using the results of central auditory tests. To address this limitation, we use a series of statistical learning frameworks for predicting a child’s cognitive abilities based on his/her central auditory performances and demographic factors. Two key challenges exist. First, children may start the study at a time when they are unable to perform the central auditory tests or cognitive tests. Second, cognitive performance is age-dependent, particularly in the early formative years of childhood and adolescence. To …
Seasonal Variations In Co2 Emission From Poultry Manure-Amended Soils In Two Contrasting Tropical Agroecosystems, Gladys M. Akande, Adebayo J. Adeyemo, Chidozie J. Oraegbunam, Iduh J.J. Otene, Ezekiel C. Are, Babatunde S. Ewulo, Chioma M. Ahukaemere, Samuel O. Kolawole, Sunday E. Obalum
Seasonal Variations In Co2 Emission From Poultry Manure-Amended Soils In Two Contrasting Tropical Agroecosystems, Gladys M. Akande, Adebayo J. Adeyemo, Chidozie J. Oraegbunam, Iduh J.J. Otene, Ezekiel C. Are, Babatunde S. Ewulo, Chioma M. Ahukaemere, Samuel O. Kolawole, Sunday E. Obalum
Applied Environmental Research
The soil remains the largest carbon sink, the capacity of which varies spatiotemporally and with anthropogenic activities, with implications for carbon dioxide (CO2) emissions and associated global warming. Despite the increasing popularity of organic amendments in the ecologically and anthropoculturally diverse farming systems of tropical Africa, manure-induced CO2 emissions in this region with high soil-carbon-sequestration potential are poorly documented. This study assessed seasonal CO2 emissions from poultry manure-amended sandy-clay-loam and sandy-loam soils in the Rainforest-Savannah and Southern Guinea Savannah zones, respectively, of Nigeria. Following manure application at 3 rates (0, 10, and 15 t ha-1), soil samples were collected during …
Assessing Forest Fragmentation And Edge Expansion In Nan Province, Thailand, Using Landsat Data (2014–2022), Kasidit Rison, Marut Fuangarworn, Chatchawan Chaisuekul
Assessing Forest Fragmentation And Edge Expansion In Nan Province, Thailand, Using Landsat Data (2014–2022), Kasidit Rison, Marut Fuangarworn, Chatchawan Chaisuekul
Applied Environmental Research
The increasing pressure from land-use change and agricultural expansion in Nan Province, northern Thailand, has accelerated forest fragmentation and reduced the ecosystem service value (ESV) of the landscape. This study aims to: assess land use and forest fragmentation change in Nan Province between 2014 and 2022, and evaluate the impact of land use change on ESV. Landsat 8 OLI satellite imagery from 2014 and 2022 was used to classify land cover into five types: forest, agriculture, settlements, exposed soil, and others. Forest fragmentation was evaluated using landscape metrics such as patch number, mean patch size, edge length, and core area. …
Environmental Sustainability Performance And Efficiency In Thailand’S Rajabhat Universities : A Cross-Regional Analysis Of The Impact Rankings, Konstantinos Balis
Environmental Sustainability Performance And Efficiency In Thailand’S Rajabhat Universities : A Cross-Regional Analysis Of The Impact Rankings, Konstantinos Balis
Applied Environmental Research
Higher education institutions (HEIs) are expected to increasingly communicate their contributions to the United Nations’ Sustainable Development Goals (SDGs), with the rise of alternative sustainability rankings serving as prominent reporting instruments for institutional transparency. In Thailand, Rajabhat Universities, a network of government HEIs historically associated with their mission of teacher training and local development, have been actively participating in the Times Higher Education (THE) Impact Rankings, presenting a unique case study to explore cross-regional sustainability efforts in relation to global benchmarks. To evaluate trends, regional disparities, and engagement performance across the sustainability pillars, this study uses a descriptive quantitative design …
Advancing Food Equity Through Explainable Ai (Xai): Identifying Place-Based Factors And Conditions Of Food Security, Leslie Hoglund, Hyoshin Park
Advancing Food Equity Through Explainable Ai (Xai): Identifying Place-Based Factors And Conditions Of Food Security, Leslie Hoglund, Hyoshin Park
Health Behavior, Policy & Management Faculty Publications
Food behaviors, food security, and their association with socioeconomic factors constitute a critical area of study with implications for public health, economic stability, and social equity. Understanding these relationships are essential for developing effective policies and interventions that promote sustainable, healthy food systems and greater food equity. This paper employs explainable artificial intelligence (XAI) methods to identify key features influencing household food behaviors. The insights gained from the XAI analysis are further utilized in conjunction with inverse reinforcement learning (IRL) to examine expert behaviors related to eating habits satisfaction. The XAI results reveal that household health conditions, spending patterns, and …
Investigating The Viability Of Fully Online Asynchronous Physics Instruction In Formal Education, Clifton W. Massey-Noel
Investigating The Viability Of Fully Online Asynchronous Physics Instruction In Formal Education, Clifton W. Massey-Noel
Physics Dissertations
In this dissertation we present results from two consecutive investigations into the fully online asynchronous modality in Physics Education. We first discuss the efficacy of a fully online asynchronous section of Modern Physics held in Fall 2024. The asynchronous section is compared with four prior partially-flipped sections of the same class, two of which were held in-person, and two of which were held synchronously online. Results suggest that all three modalities can be made to be about equally as effective. We also discuss the efficacy of a fully online asynchronous section of Calculus-Based Introductory Mechanics held in Fall 2025. The …
Advancing Lipidomics Through Fluoroalcohol-Induced Multiphase Fractionation And Orthogonal Lc×Lc–Ms Detection, Md Al Amin
Chemistry & Biochemistry Dissertations
Comprehensive characterization of the lipidome remains a significant analytical challenge due to the immense structural diversity, wide dynamic range, and complex physicochemical continuum of lipid species. Conventional extraction methods, such as those by Bligh–Dyer and Folch, and one-dimensional liquid chromatography (1D-LC) often fail to resolve this complexity, leading to chromatographic overlap, severe ion suppression, and limited coverage of low-abundance or highly hydrophobic species. This dissertation addresses these bottlenecks by establishing a separation-driven analytical framework that integrates novel fluoroalcohol-induced multiphase systems (FAiTPS) with orthogonal multidimensional liquid chromatography–mass spectrometry (LC×LC–MS).
The core of this research is the development and physicochemical characterization of …