Digital Commons Network^™

Dietary Inflammatory Index And Risk Of Colorectal Cancer In Japanese Men, Ayaka Kotemori, Kumiko Kito, Motoki Iwasaki, Taiki Yamaji, James Hébert Scd, Junko Ishihara, Manami Inoue, Shoichiro Tsugane, Norie Sawada On The Behalf Of Jphc Study Group

Faculty Publications

Background/Objectives: Unhealthy lifestyles lead to chronic low-grade inflammation, increasing the risk of colorectal cancer. Few studies in East Asia have examined the association between the dietary inflammation potential and colorectal cancer incidence. Therefore, we aimed to investigate this association further in the Japanese population. Methods: This study included 38,807 men aged 45–74 years who participated in the Japan Public Health Center-based prospective study (JPHC Study). The energy-adjusted dietary inflammatory index (E-DII) was derived from a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. Differences in risk due to a …

Microbial Communities And Biogeochemistry Of A Melting Rocky Mountain Glacier, Pacifica Sommers, Elizabeth Traver, Alison Orthel, Andrew G. Fountain, Jacki Klancher, Steven K. Schmidt

Geology Faculty Publications and Presentations

Mountain glaciers are disappearing rapidly, and with their disappearance, we may be losing unstudied biodiversity and genetic resources. A variety of habitats for microorganisms exist on glaciers, especially within pockets of supraglacial sediments (cryoconite) that support high levels of biological activity and diversity. We used biogeochemical approaches, high-throughput DNA sequencing, and microscopy to describe the biogeochemistry and microbial communities of supraglacial sediments on the Dinwoody Glacier in the Wind River Range, Wyoming. Carbon (C) and nitrogen (N) concentrations were high, and C:N ratios were close to the Redfield ratio indicating active nutrient cycling. We found unique microbial communities in sediments …

Ultrasonic Extraction-Based Analysis Of Persistent Organic Pollutants In Blubber From False Killer Whales, Michael O. Eze, Eva Borras, Mitchell M. Mccartney, Don R. Bergfelt, Kristi L. West, Sarah E. Hooper, Cristina E. Davis

Chemistry Faculty Research & Creative Works

In view of the toxic effects of persistent organic pollutants (POPs), fast and effective assessment of their concentrations in marine mammals is important for understanding individual and population-level health impacts. This study developed an ultrasonic-based method that is less time-consuming, uses minimal solvent, and thus is more sustainable than the gold standard Soxhlet method for accurate analysis of organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), and benzene hexachlorides (BHC) in false killer whale blubber. This method was developed by comparing concentrations of POPs obtained using the traditional Soxhlet and novel ultrasonic extraction methods using blubber from false killer whales (n = …

Natural Protective Mechanisms Of Cucumis Callosus Leaves In Escherichia Species-Induced Urinary Tract Infection: An Integrated In Silico And In Vivo Study, Meenal Sahu, Tripti Paliwal, Radhika Joshi, Arya Kuhu Vishwapriya, Namita Misra, Smita Jain, Gautam Singhvi, Gulshan Kumar, Devesh U. Kapoor, Dipjyoti Chakraborty, Swapnil Sharma

Michigan Tech Publications

Leaves of Cucumis callosus, traditionally employed in Ayurvedic medicine for the treatment of urinary disorders, were investigated in depth for their therapeutic potential against bacterially induced urinary tract infection (UTI) for the first time. The present work is the first to explore the antibacterial activity of C. callosus leaf fractions with an integrative in silico, in vitro, and in vivo approach. Through bioassay-guided fractionation, the chloroform fraction (F1) was identified as the most active, exhibiting potent activity against Uropathogenic Escherichia spp. species. Liquid chromatography–mass spectrometry (LC-MS) analysis of F1 revealed the presence of bioactive compounds, including stigmasterol, 1,2,3,4-tetrahydroisoquinoline, lactose, hydroxy(mesityl)acetic …

3d Reconstruction For Stadium Cad Drawings Based On Graphic Element Arrangement Pattern Analysis, Shang Ma, Mengyu Zhang, Lan Zhang, Gang Yang

Journal of System Simulation

Abstract: To address the issue of the time-consuming and labor-intensive manual conversion of two-dimensional CAD design drawings of buildings into three-dimensional models, and leveraging the characteristic that stadiums contain a large number of repetitively and regularly arranged objects, this study proposes a similar graphical element detection algorithm. This algorithm detects similarities between graphical elements by constructing their bounding boxes and calculating the L2-Norm distance, identifying all graphical elements of the same type within the CAD drawing. Furthermore, a transformation sequence detection algorithm is proposed. Based on the geometric transformation relationships between graphical elements, a geometric transformation space is defined. By …

Virtual Reality Rehabilitation Training System Based On Multimodal Brain-Computer Interface, Jing Qu, Kaining Fang, Shantong Zhu, Lingguo Bu

Journal of System Simulation

Abstract: The aging population has led to an increasing demand for rehabilitation for cognitive and motor functions. In response to the lack of interest in traditional rehabilitation and the absence of objective physiological assessment in existing virtual reality (VR) rehabilitation systems, a VR rehabilitation training system based on multimodal brain computer interface is developed by integrating VR interaction, near-infrared brain functional imaging, and motion capture technology. An immersive cognitive-motor integrated training environment was constructed to guide users in completing upper limb tasks. By recruiting subjects and synchronously collecting brain network data and Kinect upper limb motion parameters, multimodal assessment …

Full-Body Co-Speech Gesture Generation Based On Spatial-Temporal Enhanced Generation Model, Shuozhe Zhang, Wenfeng Song, Xia Hou, Shuai Li

Journal of System Simulation

Abstract: Full-body co-speech gesture generation significantly enhances the interactivity of virtual digital humans, requiring generated gestures to not only align accurately with speech but also demonstrate realistic full-body dynamics. To address limitations of existing methods—Transformer-based approaches often overlook temporal features of action sequences, while diffusion model-based ones inadequately capture spatial correlations between body parts, a full-body action generation method integrating diffusion models, Mamba, and attention mechanisms is proposed. We introduce the spatial self-attention-temporal state space model (STMamba Layer) as the core of denoising network to extract
inter-part spatial features and intra-part temporal features, thus enhancing action quality and diversity. …

Addressing The Void Of Ai Policies In Education For Students With Specific Learning Disabilities, Mikyung Shin, Fatmana Deniz, Latesha Watson, Cynthia Dieterich, Kathy B. Ewoldt, Friggita Johnson, Jennifer E. Kong, Sung Hee Lee, April Whitehurst

Education Faculty Articles and Research

The purpose of this study was to identify the current state of artificial intelligence (AI) policies in U.S. education and propose actionable recommendations through large language model–based topic modeling and Delphi surveys. Out of 12 policy documents released between 2015 and 2025, only two documents (National Center for Learning Disabilities, 2024; W.A. v. Clarksville/Montgomery County School System, 2024) specifically addressed learning disabilities. Policy documents addressing topics such as AI-driven risk assessment, data protection, legal risk management, and ethical guidelines covering other disabilities and general AI in education policy were provided as baselines that could be discussed and validated through …

Research On Real-Time Animatable Human Avatar Generation Via 3d Gaussian Splatting, Yuyou Zhong, Xukun Shen, Yong Hu

Journal of System Simulation

Abstract: Real-time animatable 3D human avatar generation technology hold significant application value in fields such as virtual reality and remote collaboration. To address the limitations of existing methods in detail modeling, real-time performance, and robustness under novel pose driving, an efficient human avatar generation and driving method based on 3D Gaussian splatting (3DGS) is proposed. This method integrates optimized parametric human reconstruction, tri-plane feature encoding, and dynamic offset prediction to achieve efficient modeling from monocular video input. By introducing a skeleton binding and visibility analysis strategy, while designing a multi-scale regularization loss to address the overfitting problem. Simulation experiments demonstrate …

Modulation Of Hypothalamic–Limbic Circuits Regulating Appetite In Response To Health Lifestyle In Obese Adults, Nour Shakir Rezaieg, Muthanna M. Awad

Karbala International Journal of Modern Science

Background: Overeating leads to obesity a low-grade inflammatory disease. In this context, aguati-related neuropeptide (AgRP) and ghrelin are pivotal players in appetite regulation, while chemerin is an adipose tissue-secreted adipokine that contributes to low-grade inflammation associated with obesity. Objective: This study used a healthy lifestyle program designed for each obese participant to identify diet-related neuro-hormonal changes in appetite regulation. Design, Setting, and Participants: This a longitudinal quasi-experimental controlled study was conducted from 1^st December 2024, to 30^th July 2025, at University of Anbar. The sample included 100 participants, 50 obese (weight between 100–140 kg) and 50 healthy participants …

Evaluation Of Mcf-7 Breast Cancer Cell Cytotoxic And Antioxidant Activities Of Peptide Fractions From Symbiotic Bacteria Of Jellyfish Catostylus Sp., Eka Sry Wahyuni, Ahyar Ahmad, Muhammad Nasrum Massi, Sofa Fajriah, Randi Rimpung, Muh. Akbar Ardiputra, Harningsih Karim, Irda Handayani

Karbala International Journal of Modern Science

Marine-derived symbiotic microorganisms are recognized as a promising source of bioactive compounds with potential therapeutic applications, yet research on jellyfish-associated bacteria remains limited. This study examines the bioactivity of peptide fractions derived from symbiotic bacteria isolated from the jellyfish Catostylus sp., collected from the coastal waters of South Sulawesi, Indonesia, with a focus on their anticancer and antioxidant properties. Following sample collection, the symbiont bacteria were isolated, enzymatically hydrolyzed, and purified before their biological activity was evaluated. Preliminary cytotoxicity screening using the brine shrimp lethality assay revealed that the extracellular peptide fraction (5–10 kDa) and intracellular peptide fraction (3–5 kDa) …

Single-Valued Neutrosophic Pessimistic Multi-Granulation Rough Set Model Based On (A,B,C)-Cut Relations And Its Applications, Xu-Xi Wu, Hu Zhao, Qiao-Ling Song, Xiong-Wei Zhang

Neutrosophic Systems with Applications

To address uncertainty in multi-source data, this paper proposes a single-valued neutrosophic pessimistic multi-granulation rough set (P-SVN-MGRS) model based on (a,b,c)-cut relations. In this framework, each neutrosophic relation is characterized by three membership-degree functions: T(x,y), I(x,y), and F(x,y). These functions correspond to truth-membership, indeterminacy, and falsity, respectively. The (α,β,γ)-cut relation employs parameters α,β,γ∈(0,1] as thresholds for the three functions. A pair (x,y) belongs to …

Pythagorean Neutrosophic Mathematical Modelling, M. Kavitha, R. Irene Hepzibah

Neutrosophic Systems with Applications

Survey-based assessments often suffer from ambiguity, inconsistency, and uncertainty, which weaken the reliability of decision-making outcomes. To address these challenges, this study proposes a novel decision-support framework for data fuzzification, ranking, and agility measurement using Pythagorean Neutrosophic Fuzzy Sets (PNFS). The proposed method offers three major advantages: (i) enhanced ability to capture high levels of indeterminacy compared with classical fuzzy and intuitionistic models, (ii) improved ranking accuracy through a newly developed score function and ranking algorithm, and (iii) greater robustness in scenarios involving conflicting, incomplete, or imprecise expert judgments. The framework includes a refined Pythagorean Neutrosophic fuzzification technique, mathematically supported …

Neutrosophic Hankel Transforms And Their Application To Cross-Domain Legislative Integration, Mona Gharib, Mehboob Ali, Ishtiaq Hussain

Neutrosophic Systems with Applications

This paper introduces the Neutrosophic Hankel Transform (NHT) as a novel mathematical framework for modeling systems with radial structure under uncertainty, indeterminacy, and inconsistency. Building upon classical Hankel transforms and neutrosophic logic, we define two complementary realizations: a componentwise transform (NHT–C) that transports uncertainty with the signal, and a kernel-weighted transform (NHT–K) that embeds neutrosophic weights into the integral kernel. We establish linearity, inversion, and Parseval-type relations, and derive operational rules that diagonalize the Bessel radial operator.

To demonstrate utility, we formulate a radial diffusion–reaction model for pollutant concentration in a radialized river cross-section and solve it in closed form …

From Uncertainty To Lucidity: Awareness Neutrosophic Kähler-Einstein Innovative Evaluator Methodological In Era Of Green Artificial Intelligence, Mona Mohamed, Ahmed M. Ali

Neutrosophic Systems with Applications

The rapid development of generative artificial intelligence (Gen AI) is a double-edged sword. On the positive side, Large Language Models (LLMs) of Gen AI as chatbot considered intelligent friend. Due to its potential to stimulate the maturation of ideas and cultivate fundamental general abilities like problem-solving and critical thinking. The advancement of Gen AI continued after that, moving from “chatbots” to “AI agents” that carry out multi-step activities in addition to responding to queries.

Regarding the downside, the terminology of “Red AI” era brought about by generative AI is marked by a performance at any expense that puts pressure on …

Of Metaphors And Measurements: Cross-Disciplinary Learning In K-8 English Language Arts And Mathematics, Morgan Shiver, Janet Shiver

New Jersey English Journal

English Language Arts and mathematics may seem like an unlikely pair, but together, literature and math can foster meaningful cross-disciplinary learning. This article presents strategies for using literature in K-8 classrooms to meet both ELA and math standards, enhancing student engagement and comprehension.

Confluence, Vol. 4, Iss. 2, Full Issue

The Confluence

No abstract provided.

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …

Optimal Quantization Of Finite Uniform Data On The Sphere, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

This paper develops a systematic and geometric theory of optimal quantization on the unit sphere 𝕊2, focusing on finite uniform probability distributions supported on the spherical surface—rather than on lower-dimensional geodesic subsets such as circles or arcs. We first establish the existence of optimal sets of n-means and characterize them through centroidal spherical Voronoi tessellations. Three fundamental structural results are obtained. First, a cluster-purity theorem shows that when the support consists of well-separated components, each optimal Voronoi region remains confined to a single component. Second, a ring allocation (discrete water-filling) theorem provides an explicit rule describing how optimal representatives are …

Antibacterial Peptides From Soybean (Glycine Max (L.) Merr.) With In Silico Study Against Escherichia Coli Bacteria, Dian Riana Ningsih, Ely Setiawan, Purwati Purwati, Zusfahair Zusfahair, Anita Hindayanti Rukmana

Karbala International Journal of Modern Science

Bioactive peptides are produced from soy milk protein hydrolysis using trypsin. The research began with the preparation and separation of soy milk protein, followed by fractionation using ammonium sulphate, protein hydrolysis, and SDS-PAGE analysis of protein hydrolysates. Fractions exhibiting the highest degree of hydrolysis were further fractionated by SPE and tested to determine the antibacterial activity Staphylococcus aureus and Escherichia coli. The peptide sequence of the active peptide as an antibacterial was identified, employing LC-HRMS. The mode of action between active peptides and bacterial membran was analysed using molecular dynamics (MD) simulation. The findings displayed that F15 contained the highest …

Animal Taxa Threatened By Adverse Fire Regimes In Western Australia: A Synthesis And Outlook, Tim S. Doherty, Mark G. Allen, Karlene Bain, Stephen Beatty, Allan H. Burbidge, Renee A. Catullo, Sarah Comer, Ben Corey, Saul J. Cowen, Robert A. Davis, Martin A. Dziminski, J. Anthony Friend, Bruce Greatwich, Mark S. Harvey, Hannah Killian, Michael E. Klunzinger, Damian C. Lettoof, Nicola J. Mitchell, Melinda Moir, Harry A. Moore, David L. Morgan, Ian J. Radford, Michael J. Rix, Tom Vigilante, Adrian F. Wayne, Corey Whisson, Nicole Willers, Matthew R. Williams

Natural Resources Research Articles

Adverse fire regimes threaten biodiversity, potentially leading to population declines and increased extinction risk. Understanding how varying fire regimes affect threatened species is essential for effective ecosystem management, including in Western Australia where diverse ecosystems are exposed to wildfires, Indigenous burning, and prescribed fire. We compiled and synthesised data on the threat of adverse fire regimes to threatened animal taxa in Western Australia. Using a threat classification scheme, we ranked adverse fire regimes as having either no, low, medium, high, or unknown impact on each taxon. A total of 212 taxa were reviewed, 153 (72%) of which are considered fire-threatened: …

Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer

LSU Doctoral Dissertations

Emerging infectious diseases pose imminent risk to the marine realm and coral reefs in particular. Since its emergence in 2014, stony coral tissue loss disease (SCTLD) has dramatically reduced living coral cover in Florida and charted a similar course in the Caribbean. SCTLD is by far the most severe coral disease in history and has driven highly susceptible species to local extinction, yet the mechanisms driving the regional epizootic are not well understood. Here, we developed reef-scale parameterizations of disease spread using model sites in the lower Florida Keys, developed extensive metacommunity habitat maps for the US Caribbean, and then …

Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed

Karbala International Journal of Modern Science

In recent years, the classification of oral diseases has gained significant attention due to its influence on public health and the necessity for early and accurate diagnosis. Traditional diagnosis depends on manual clinical assessment, which can be slow and subjective. An optimized and subsequently quantized model is required to provide a faster and more consistent diagnostic support tool. This paper proposes an optimized ResNet-18 architecture for the classification of six oral diseases. The optimization process is based on removing the Rectified Linear Unit (ReLU), Batch Normalization (BN), and convolutional layers from the base ResNet-18 blocks that contain 128 filters. This …

Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi

Karbala International Journal of Modern Science

Background: While male infertility has become a significant global health concern, conventional analysis of semen has not made progress in the detection of contraindicated molecular biomarkers, such as sperm-associated antigen 6 (SPAG6), which is a protein involved in axonemal structure and flagellar motility.

Hypothesis: Expression of SPAG6 correlates with sperm motility and structural integrity. This means that its dysregulation may serve as a molecular indicator of impaired sperm performance.

Methods: A comprehensive review of recent studies was conducted with a focus on SPAG6’s molecular characteristics, expression patterns in normal versus abnormal spermatozoa, and the role it plays in motility-related …

Optimized Co2 Gas Sensing With Sns:Sm2o3/N-Si Nanocomposites Fabricated Via Spray Pyrolysis, Wasan A. Khalaf, Mays A. Hammadi, Mohammed J. Alsultani, Yahya R. Hathal, Mohammed O. Salman

Karbala International Journal of Modern Science

In this work, tin sulfide:samarium oxide (SnS:Sm₂O₃) composite films were deposited using a spray pyrolysis technique for room-temperature CO₂ gas sensing. X-ray diffraction (XRD) confirmed a polycrystalline SnS nature of orthorhombic-phase crystallinity at 10 at.% Sm ions, while 20 at.% Sm induced Sm₂O₃ as a separate phase. Field emission-scanning electron microscopy (FE-SEM) induced uniform grains and increased the surface roughness, enhancing gas adsorption. UV-visible absorbance revealed band-gap narrowing. Fourier transform infrared spectroscopy (FTIR) analysis revealed vibrational band shifts, confirming the structural modifications. Gas-sensing measurements demonstrated 5.72%, 19.65%, and 9.65% for pure SnS, …

Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata

Spora: A Journal of Biomathematics

This study employed an age-structured Susceptible-Infected-Recovered-Vaccinated-Deceased (SIRVD) model to design optimal COVID‑19 intervention strategies by integrating epidemiological dynamics with economic costs. Using empirical data from South Korea, we estimated transmission parameters and analyzed quarantine-based non-pharmaceutical interventions (NPIs) alongside targeted vaccination scenarios. Our results indicated that a stronger form of mild NPI (upper range of Level I), when combined with targeted vaccination that prioritized seniors, achieved substantial reductions in infection peaks and overall economic burden. These findings underscore the effectiveness of age-specific strategies in epidemic management and offer critical insights for policymakers seeking balanced, resource-efficient approaches.

Inhomogeneous Branching Random Walks: Incorporating Genealogy And Density Effects, Lauren Ajax, Beatrice Durham, Pratima Hebbar, Cade Johnston, Jiayi Zhang

Spora: A Journal of Biomathematics

We introduce a novel framework using inhomogeneous branching random walks (BRWs) to model biological processes, specifically by introducing genealogy-dependence in branching rates and displacement distributions to model bacterial colony growth. Current stochastic models often either assume independent and identical behavior of individual agents or incorporate only spatiotemporal inhomogeneity, ignoring the effect of genealogy-based inhomogeneity on the long-time behavior of these processes. Such asymptotics are of independent mathematical interest and are crucial in understanding the emergence of patterns. We propose several inhomogeneous BRW models in 2D space where displacement distributions and branching rates vary with time, space, and genealogy. A combined …

The Sunday Math Circle, Nathan Pflueger

Journal of Math Circles

Bob and Ellen Kaplan envisioned and organized a style of math circle centered on the idea that children of all ages can work like mathematicians do: creatively, collaboratively, and ecstatically. This article surveys four sample topics covered during a Sunday morning math circle in the Boston area, based on Bob and Ellen's invaluable guidance. I also offer some reflections on what I learned from Bob and Ellen, and how it is reflected in these math circles.

Study On Visualization Simulation And System Dynamic Optimization Of The Ore Drawing Process In Mine Chutes, Liang Juan, Zhu Quanjie, Hao Yingnan, Quan Zhongxue, Zhang Zhiwu, Liu Xiaohuic, Ouyang Zhihua

Journal of Sustainable Mining

The ore release process in metal mine chutes is a critical part of the mining operation. Based on the urgent demand for intelligent mining construction, this paper proposes a visualization simulation and dynamic optimization method for the mine chute ore release process using the open-source programs Python and Blender. The main research content includes: designing the simulation method and model for the ore release process, including the main control program, process subprograms, etc.; proposing a visualization simulation method for the mine chute ore release process based on Blender, studying the impact of ore shape and size on ore release efficiency, …

Assessment Of Heavy Metal Contamination In Surface Water Near Tailings Dam, Gera Techane Mengistu, Tesema Kebede, Enatfenta Melaku, Engdasew Temere

Journal of Sustainable Mining

Elevated levels of heavy metals in surface water can lead to the degradation of water quality, especially in mining areas where tailing dams are sources of heavy metal pollution. This study focuses on evaluating the concentrations of heavy metals in surface water near the Legadembi tailings dams. The mean concentrations (in µg/L) of various heavy metals including: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), antimony (Sb), selenium (Se), thallium (Tl), uranium (U), vanadium (V), tungsten (W), zinc (Zn), and zirconium (Zr) were determined: 79.7, 0.15, 162.3, 0.66, 18.1, 0.01, …