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A Machine Learning Approach For Dyslexia Detection Using Turkish Audio Records, Tuğberk Taş, Muhammed Abdullah Bülbül, Abas Haşi̇moğlu, Yavuz Meral, Yasi̇n Çalişkan, Gunay Budagova, Mücahi̇d Kutlu Sep 2023

A Machine Learning Approach For Dyslexia Detection Using Turkish Audio Records, Tuğberk Taş, Muhammed Abdullah Bülbül, Abas Haşi̇moğlu, Yavuz Meral, Yasi̇n Çalişkan, Gunay Budagova, Mücahi̇d Kutlu

Turkish Journal of Electrical Engineering and Computer Sciences

Dyslexia is a learning disorder, characterized by impairment in the ability to read, spell, and decode letters. It is vital to detect dyslexia in earlier stages to reduce its effects. However, diagnosing dyslexia is a time-consuming and costly process. In this paper, we propose a machine-learning model that predicts whether a Turkish-speaking child has dyslexia using his/her audio records. Therefore, our model can be easily used by smart phones and work as a warning system such that children who are likely to be dyslexic according to our model can seek an examination by experts. In order to train and evaluate, …

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Learning To Care For Dangaba, Anne Poelina, Yin Paradies, Sandra Wooltorton, Edwin L. Mulligan, Laurie Guimond, Libby Jackson-Barrett, Mindy Blaise Sep 2023

Learning To Care For Dangaba, Anne Poelina, Yin Paradies, Sandra Wooltorton, Edwin L. Mulligan, Laurie Guimond, Libby Jackson-Barrett, Mindy Blaise

Research outputs 2022 to 2026

In a Kimberley place-based cultural story, Dangaba is a woman whose Country holds poison gas. Her story shows the importance of cultural ways of understanding and caring for Country, especially hazardous places. The authors contrast this with a corporate story of fossil fuel, illustrating the divergent discourses and approaches to place. Indigenous and local peoples and their knowledge, cultures, laws, philosophies and practices are vitally important to Indigenous lifeways and livelihoods, and critically significant to the long-term health and well-being of people and place in our locality, region and world. We call for storying and narratives from the pluriverse of …

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Stepwise Dynamic Nearest Neighbor (Sdnn): A New Algorithm For Classification, Deni̇z Karabaş, Derya Bi̇rant, Peli̇n Yildirim Taşer Sep 2023

Stepwise Dynamic Nearest Neighbor (Sdnn): A New Algorithm For Classification, Deni̇z Karabaş, Derya Bi̇rant, Peli̇n Yildirim Taşer

Turkish Journal of Electrical Engineering and Computer Sciences

Although the standard k-nearest neighbor (KNN) algorithm has been used widely for classification in many different fields, it suffers from various limitations that abate its classification ability, such as being influenced by the distribution of instances, ignoring distances between the test instance and its neighbors during classification, and building a single/weak learner. This paper proposes a novel algorithm, called stepwise dynamic nearest neighbor (SDNN), which can effectively handle these problems. Instead of using a fixed parameter k like KNN, it uses a dynamic neighborhood strategy according to the data distribution and implements a new voting mechanism, called stepwise voting. Experimental …

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Molecularly Imprinted Electrochemical Sensor Based On Poly (O-Phenylenediamine) For Sensitive Detection Of Oxycodone In Water, Pranaya Charkravarthula, Amos Mugweru Sep 2023

Molecularly Imprinted Electrochemical Sensor Based On Poly (O-Phenylenediamine) For Sensitive Detection Of Oxycodone In Water, Pranaya Charkravarthula, Amos Mugweru

College of Science & Mathematics Departmental Research

This work was aimed at the development of a sensitive electrochemical detection method for oxycodone in water. Molecularly imprinted electrodes were formed by electro-polymerization process using o-phenylenediamine as a monomer. The electro-polymerization was performed on glassy carbon electrodes in the presence of oxycodone before the extraction of entrapped oxycodone molecules. Various electrochemical techniques were employed to monitor the polymerization and response of the fabricated electrodes toward oxycodone. These techniques included cyclic voltammetry (CV), square wave voltammetry (SWV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The oxycodone concentration was determined using SWV by measuring the change in the oxidation …

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Seasonal Dynamics Of Karst Surface Dissolution Based On A Limestone Tables Experiment (Slovak Karst), Alena Gessert, Zdenko Hochmuth Sep 2023

Seasonal Dynamics Of Karst Surface Dissolution Based On A Limestone Tables Experiment (Slovak Karst), Alena Gessert, Zdenko Hochmuth

International Journal of Speleology

Chemical denudation in karst is the basic process of karst relief formation. However, it is influenced by many factors of varying intensity that depend on the climatic conditions and characteristics of each given location. Based on measurable results of weight loss of limestone tablets, we monitored the intensity of chemical denudation in two areas of the Slovak Karst, Silica Plateau and Jasov Plateau that are situated in the most developed karst plateau region of Slovakia. Both experimental sites are similar in terms of geographical conditions, thus comparable between them. In each locality, we placed three sets of standardized tablets at …

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Self-Organization For Community Resilience In An Invisible Agricultural Community, Anna Erwin, Chelsea A. Silva, Zhao Ma Sep 2023

Self-Organization For Community Resilience In An Invisible Agricultural Community, Anna Erwin, Chelsea A. Silva, Zhao Ma

School of Earth, Environmental, & Marine Sciences Faculty Publications

This study investigates how self-organizing efforts by residents of informal settlements, primarily migrant and informal farmworkers, shape community resilience in Majes, a water-scarce irrigation district in the Atacama Desert of Peru. We collected 45 semi-structured interviews with residents and authorities in Majes and analyzed findings through a framework of self-organizing. Analyses revealed that self-organizing by residents of informal settlements incorporated the three components of White’s theory of Community Agency and Community Resilience, which contends that marginalized communities increase resilience by fostering a commons praxis, practicing a prefigurative politics, and developing opportunities for economic autonomy. We also found …

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Virtual Impacts Of Food Consumption And Opportunities For Closing Resource Loops, Vikas Khanna Sep 2023

Virtual Impacts Of Food Consumption And Opportunities For Closing Resource Loops, Vikas Khanna

Sustainability Seminar Series

Food supply chains have become increasingly complex and characterized by large distances between production and consumption. The first part of this talk will describe an optimization based-model to track the US beef supply chain with a focus on quantifying virtual water and nitrogen impacts. The second part of this presentation will discuss a novel AnMBR (anaerobic membrane bioreactor) platform for resource recovery from animal wastewater streams. Life cycle assessment and techno-economic analysis of the AnMBR platform will be discussed with implications for circular economy.

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3d Garment Collision Simulation Based On Human Skeletal Features, Yuanyuan Chen, Yongjian Huai, Xiaoying Nie, Ke Lang Sep 2023

3d Garment Collision Simulation Based On Human Skeletal Features, Yuanyuan Chen, Yongjian Huai, Xiaoying Nie, Ke Lang

Journal of System Simulation

Abstract: In order to enhance the realism of garment and human body collision in real-time fabric simulation, an automated human body fitting collision method based on the bounding box and mesh method is proposed. According to the human skeletal structure and garment type, the skeletal information involved in collision simulation is effectively optimized, so as to better obtain the feature points of the human body and semantically segment them. According to the characteristics of skinning animation, simple capsule colliders and mesh colliders are generated to fit the geometric shape of the human body, and the dynamic following of colliders is …

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Virtual Navigation Path Planning Based On Octree Potential Field For Endonasal Endoscope, Wenjing Li, Yanlin Luo, Yuhui Wang, Li Zhu Sep 2023

Virtual Navigation Path Planning Based On Octree Potential Field For Endonasal Endoscope, Wenjing Li, Yanlin Luo, Yuhui Wang, Li Zhu

Journal of System Simulation

Abstract: Virtual navigation can intuitively display the internal structure of human tissue from multiple viewpoints. The navigation path planning algorithm is the key to achieving excellent navigation effects. The traditional centerline extraction algorithm can ensure a wide field of view during navigation, but the time efficiency is not high enough on the complex nasal-skull base volume model. To solve the problem, a rapid navigation path planning algorithm based on the octree potential field is proposed. The space outside the obstacles is modeled by an octree, and the octree potential field is constructed by calculating the potential of all the octree …

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Synthesis, Characterization, Antibacterial Activity, And Potential Water Filter Application Of Copper Oxide/Zeolite Composite, Elfa Aida Kamila, Zaenal Abidin, Irma Isnafia Arief, Trivadila Trivadila Sep 2023

Synthesis, Characterization, Antibacterial Activity, And Potential Water Filter Application Of Copper Oxide/Zeolite Composite, Elfa Aida Kamila, Zaenal Abidin, Irma Isnafia Arief, Trivadila Trivadila

Makara Journal of Science

Detection of E. coli bacteria in water samples can indicate the presence of other bacterial contamination in feces. Bacterial contamination can be treated with antibiotics, but excessive use of antibiotics leads to the emergence of multiresistant bacteria. Therefore, alternative antibacterial agents must be explored. Copper ion/zeolite composite has been widely studied as an antibacterial agent. However, the released copper ions accumulate in water and are toxic to humans; this can be prevented by converting copper ions into copper oxides (CuO and Cu2O). In this study, copper oxide/zeolite composite is synthesized and characterized using the heating method, followed by …

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Isolation Of Lignin From Sugarcane Bagasse As An Adsorbent For Chromium Ion, Nila Tanyela Berghuis, Nurul Fitri Novianti, Paramita Jaya Ratri Sep 2023

Isolation Of Lignin From Sugarcane Bagasse As An Adsorbent For Chromium Ion, Nila Tanyela Berghuis, Nurul Fitri Novianti, Paramita Jaya Ratri

Makara Journal of Science

The waste generated in metal coating and leather tanning industries contribute to water pollution owing to the use of Cr metal in production processes. The utilization of lignin from natural base materials in the form of bagasse can reduce unwanted waste from production processes and adsorb Cr ion waste. In this study, lignin was successfully isolated from bagasse waste and then carbonized and applied in Cr metal absorption. Lignin and lignin carbon as an absorbent were characterized using Fourier-transform infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The ability of bagasse lignin and carbon lignin to absorb Cr ion waste …

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Chicken Immune Responses To Vaccination By The Avian Influenza Subtype H5n1 Against Avian Influenza, Ramlah Ramlah, Sri Murtini, Retno Damayanti Soejoedono, Ketut Karuni Nyanakumari Natih, Siti Gusti Ningrum Sep 2023

Chicken Immune Responses To Vaccination By The Avian Influenza Subtype H5n1 Against Avian Influenza, Ramlah Ramlah, Sri Murtini, Retno Damayanti Soejoedono, Ketut Karuni Nyanakumari Natih, Siti Gusti Ningrum

Makara Journal of Science

Avian Influenza (AI) is one of the strategic animal diseases still considered a priority for control by the Indonesian government. This study aimed to examine the immune response of chickens to various types of H5N1 subtype AI vaccines in Indonesia and to determine the correlation of factors influencing the post-vaccination AI antibody response. Serum samples were tested using the hemagglutination inhibition (HI) test with the standard AI antigen subtype H5N1 strain A/Chicken/Barru/BBVM/41-13/2013 (Clade 2.1.3) and strain A/Chicken/Semarang/04141225-07/2014 (Clade 2.3.2). Antibody titer was calculated using the Geometric Mean Titer (GMT). The correlation analyses were performed to assess the correlation of antibody …

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Effects Of Weight Initialization Methods On Ffn's, Ida K. Karem Sep 2023

Effects Of Weight Initialization Methods On Ffn's, Ida K. Karem

The Cardinal Edge

Weight initialization is the method of determining starting values of weights in a neural network. The way this method is done can have massive effects on the network[2, 3, 6, 9] and can halt training if not handled properly. On the other hand, if initialization is chosen tactfully it can improve training and accuracy greatly. The initialization method usually called Normalized Xavier will be referred to as Nox in this paper to avoid confusion with the Xavier initialization method. This study analyzes five methods of weight initialization(Nox, He, Xavier, Plutonian, and Self-Root), two of them …

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Wind River Elementary Computer Science Collaborative: Connecting Computer Science And Indigenous Identities And Knowledges On The Wind River Reservation, Joseph P. Wilson, Kathryn M. Rich, Jared O'Leary, Veronica Miller Sep 2023

Wind River Elementary Computer Science Collaborative: Connecting Computer Science And Indigenous Identities And Knowledges On The Wind River Reservation, Joseph P. Wilson, Kathryn M. Rich, Jared O'Leary, Veronica Miller

Journal of Computer Science Integration

Three Northern Arapaho and Eastern Shoshone–serving districts formed a researcher–practitioner partnership with the Wyoming Department of Education, the American Institutes for Research®, and BootUp Professional Development to advance the computer science (CS) education of their elementary students in ways that strengthen their Indigenous identities and knowledges. In this paper, we share experiences from 2019 to 2022 with our curriculum development, professional development (PD), and classroom implementation. The researcher–practitioner partnership developed student and teacher materials to support elementary CS lessons aligned to Wyoming’s CS standards and “Indian Education for All” social studies standards. Indigenous community members served as experts to codesign …

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Dual Activation Of Peroxymonosulfate Using Mnfe2O4/G‑C3N4 And Visible Light For The Efficient Degradation Of Steroid Hormones: Performance, Mechanisms, And Environmental Impacts, Kitipong Poomipuen, Chainarong Sakulthaew, Chanat Chokejaroenrat, Athaphon Angkaew, Kanidrawee Techauay, Thapanee Poompoung, Kanokwan Teingtham, Piyaporn Phansak, Piyangkun Lueangjaroenkit, Daniel D. Snow Sep 2023

Dual Activation Of Peroxymonosulfate Using Mnfe2O4/G‑C3N4 And Visible Light For The Efficient Degradation Of Steroid Hormones: Performance, Mechanisms, And Environmental Impacts, Kitipong Poomipuen, Chainarong Sakulthaew, Chanat Chokejaroenrat, Athaphon Angkaew, Kanidrawee Techauay, Thapanee Poompoung, Kanokwan Teingtham, Piyaporn Phansak, Piyangkun Lueangjaroenkit, Daniel D. Snow

School of Natural Resources: Faculty Publications

Single activation of peroxymonosulfate (PMS) in a homogeneous system is sometimes insufficient for producing reactive oxygen species (ROS) for water treatment applications. In this work, manganese spinel ferrite and graphitic carbon nitride (MnFe2O4/g-C3N4; MnF) were successfully used as an activator for PMS under visible light irradiation to remove the four-mostdetected- hormone-contaminated water under different environmental conditions. The incorporation of g-C3N4 in the nanocomposites led to material enhancements, including increased crystallinity, reduced particle agglomeration, amplified magnetism, improved recyclability, and increased active surface area, thereby facilitating the PMS activation and electron …

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Dual Activation Of Peroxymonosulfate Using Mnfe2O4/G‑C3N4 And Visible Light For The Efficient Degradation Of Steroid Hormones: Performance, Mechanisms, And Environmental Impacts, Kitipong Poomipuen, Chainarong Sakulthaew, Chanat Chokejaroenrat, Athaphon Angkaew, Kanidrawee Techauay, Thapanee Poompoung, Kanokwan Teingtham, Piyaporn Phansak, Piyangkun Lueangjaroenkit, Daniel D. Snow Sep 2023

Dual Activation Of Peroxymonosulfate Using Mnfe2O4/G‑C3N4 And Visible Light For The Efficient Degradation Of Steroid Hormones: Performance, Mechanisms, And Environmental Impacts, Kitipong Poomipuen, Chainarong Sakulthaew, Chanat Chokejaroenrat, Athaphon Angkaew, Kanidrawee Techauay, Thapanee Poompoung, Kanokwan Teingtham, Piyaporn Phansak, Piyangkun Lueangjaroenkit, Daniel D. Snow

Daugherty Water for Food Global Institute: Faculty Publications

Single activation of peroxymonosulfate (PMS) in a homogeneous system is sometimes insufficient for producing reactive oxygen species (ROS) for water treatment applications. In this work, manganese spinel ferrite and graphitic carbon nitride (MnFe2O4/g-C3N4; MnF) were successfully used as an activator for PMS under visible light irradiation to remove the four-mostdetected- hormone-contaminated water under different environmental conditions. The incorporation of g-C3N4 in the nanocomposites led to material enhancements, including increased crystallinity, reduced particle agglomeration, amplified magnetism, improved recyclability, and increased active surface area, thereby facilitating the PMS activation and electron …

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Ocean Negative Carbon Emissions In The Context Of Earth System Science, Nianzhi Jiao, Tingwei Luo, Jihua Liu, Quanrui Chen, Chenba Zhu Sep 2023

Ocean Negative Carbon Emissions In The Context Of Earth System Science, Nianzhi Jiao, Tingwei Luo, Jihua Liu, Quanrui Chen, Chenba Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Comparing the records of geological events and the observations of the current climate, the debate on the main cause of global warming, which has lasted for more than 30 years, is now to an end. Along the global consensus, it is imperative to seek effective solutions to the mitigation of climate change for China and the countries along Belt and Road route, which are facing the unavoidable conflicts between development and protection. Based on these analyses, The study proposes that reasonable and legitimate transformative Ocean Negative Carbon Emission (ONCE) approach should be developed in the context of Earth system science …

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Strategies And Measures Of International Climate Cooperation For The Belt And Road Regions, Yi Wang, Xianchun Tan, Jingyong Zhang, Renqiang Li, Minpeng Chen, Baihe Gu, Jianping Zhang Sep 2023

Strategies And Measures Of International Climate Cooperation For The Belt And Road Regions, Yi Wang, Xianchun Tan, Jingyong Zhang, Renqiang Li, Minpeng Chen, Baihe Gu, Jianping Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Climate cooperation is conducive to promoting the Belt and Road Initiative (BRI) partner countries and regions to handle the relationship between economic development and tackling climate change, which is critical to achieving the green transformation of the regional economy. Based on the facts and projections of climate change in the BRI region, this study explored the demand gaps in technology, finance, and capacity building in the BRI region based on the impact of climate change on water resources, agriculture, and biodiversity. The study found that most countries and regions along the Belt and Road have a more urgent need for …

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The Influence Of Polystyrene Microplastics On Juvenile Steelhead Trout (Oncorhynchus Mykiss), Kaitlyn Marie Baker Sep 2023

The Influence Of Polystyrene Microplastics On Juvenile Steelhead Trout (Oncorhynchus Mykiss), Kaitlyn Marie Baker

Dissertations and Theses

Mass production of plastic within the past decade has led to over 100 billion tons of plastics being added to the world’s oceans through rivers and effluent disposal and decomposition. For marine environments, the sudden and constant growth of microplastics (plastics 1 µm to 5 mm in diameter), is of particular concern to top-predatory fish such as steelhead trout (Oncorhynchus mykiss), who passively or actively uptake microplastics while consuming prey. Previous research has demonstrated clear detrimental impacts of microplastic accumulation in bivalves, seabirds, and zebrafish, including decreased diet, reproduction rates, and metabolism, as well as increased rates of …

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Exploring Nonprofit Views On Water Management And Conservation Strategies, Jillian Marie Farley Sep 2023

Exploring Nonprofit Views On Water Management And Conservation Strategies, Jillian Marie Farley

Dissertations and Theses

Valuing water resources presents a multitude of methodological and theoretical challenges, including economics, biodiversity, and cultural significance. Information is not readily available on the individuals working every day on water resource management and how they navigate such a complex topic. This project is designed to help all parties better understand the opinions of individuals working for nonprofit organizations and Watershed Councils in the State of Oregon about current methods of water resource conservation. The results reflect respondents’ personal views on the process and practices of valuing water and are designed to prompt deeper discussions between the organizations, communities, and policymakers. …

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Climate Change Impacts And Adaptation To Permafrost Change In High Mountain Asia: A Comprehensive Review, Prashant Baral, Simon Allen, Jakob F. Steiner, Tika R. Gurung, Graham Mcdowell Sep 2023

Climate Change Impacts And Adaptation To Permafrost Change In High Mountain Asia: A Comprehensive Review, Prashant Baral, Simon Allen, Jakob F. Steiner, Tika R. Gurung, Graham Mcdowell

Department of Earth and Atmospheric Sciences: Faculty Publications

Changing climatic conditions in High Mountain Asia (HMA), especially regional warming and changing precipitation patterns, have led to notable effects on mountain permafrost. Comprehensive knowledge of mountain permafrost in HMA is mostly limited to the mountains of the Qinghai-Tibetan Plateau, with a strong cluster of research activity related to critical infrastructure providing a basis for related climate adaptation measures. Insights related to the extent and changing characteristics of permafrost in the Hindu Kush Himalaya (HKH), are much more limited. This study provides the first comprehensive review of peer-reviewed journal articles, focused on hydrological, ecological, and geomorphic impacts associated with thawing …

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Floating Vegetation As A Driver Of Ch4 Emissions In Small Ponds Across Louisville, Ky, Mark Tierney, C. Jalink, J. H. Loughrin, S. W. Antle, Andrew S. Mehring Sep 2023

Floating Vegetation As A Driver Of Ch4 Emissions In Small Ponds Across Louisville, Ky, Mark Tierney, C. Jalink, J. H. Loughrin, S. W. Antle, Andrew S. Mehring

Kentucky Water Resources Annual Symposium

No abstract provided.

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Full Program Proceedings For 2023 Kentucky Water Resources Symposium, Kentucky Water Research Institute Sep 2023

Full Program Proceedings For 2023 Kentucky Water Resources Symposium, Kentucky Water Research Institute

Kentucky Water Resources Annual Symposium

No abstract provided.

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Chlorinated Water As A Source Of Chlorate Contamination In Farm Bulk Milk, Lorna Twomey, Ambrose Furey, Bernadette O'Brien, David Gleeson Sep 2023

Chlorinated Water As A Source Of Chlorate Contamination In Farm Bulk Milk, Lorna Twomey, Ambrose Furey, Bernadette O'Brien, David Gleeson

Physical Sciences Publications

The potential for chlorinated water to cause chlorate contamination of milk was evaluated at both laboratory and field level. It was found that for such contamination to occur, direct contact of water and milk was necessary. To minimise the opportunity for chlorinated water to cause chlorate contamination of milk, it is vital to ensure that milk handling equipment is engineered to provide for proper drainage of water and that all necessary steps are taken to prevent the adulteration of milk with water.

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History And Current Status Of Mediterranean Spotted Fever (Msf) In The Crimean Peninsula And Neighboring Regions Along The Black Sea Coast, Muniver T. Gafarova, Marina E. Eremeeva Sep 2023

History And Current Status Of Mediterranean Spotted Fever (Msf) In The Crimean Peninsula And Neighboring Regions Along The Black Sea Coast, Muniver T. Gafarova, Marina E. Eremeeva

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Mediterranean spotted fever (MSF) is a tick-borne rickettsiosis caused by Rickettsia conorii subspecies conorii and transmitted to humans by Rhipicephalus sanguineus ticks. The disease was first discovered in Tunisia in 1910 and was subsequently reported from other Mediterranean countries. The first cases of MSF in the former Soviet Union were detected in 1936 on the Crimean Peninsula. This review summarizes the historic information and main features of MSF in that region and contemporary surveillance and control efforts for this rickettsiosis. Current data pertinent to the epidemiology of the disease, circulation of the ticks and distribution of animal hosts are discussed …

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Mettl14 Is A Chromatin Regulator Independent Of Its Rna N6-Methyladenosine Methyltransferase Activity, Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu Sep 2023

Mettl14 Is A Chromatin Regulator Independent Of Its Rna N6-Methyladenosine Methyltransferase Activity, Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu

Faculty, Staff and Student Publications

METTL3 and METTL14 are two components that form the core heterodimer of the main RNA m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 or METTL14 displayed distinct effects on stemness maintenance of mouse embryonic stem cell (mESC). While comparable global hypo-methylation in RNA m6A was observed in Mettl3 or Mettl14 knockout mESCs, respectively. Mettl14 knockout led to a globally decreased nascent RNA synthesis, whereas Mettl3 depletion resulted in transcription upregulation, suggesting that METTL14 might possess an m6A-independent role in gene regulation. We found that METTL14 colocalizes with the repressive H3K27me3 modification. Mechanistically, METTL14, but not METTL3, binds …

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Microplastics In Water, Their Effects On The Aquatic Ecosystem And Human Public Health, And The Proposed Solutions, Mohanad Abouserie Sep 2023

Microplastics In Water, Their Effects On The Aquatic Ecosystem And Human Public Health, And The Proposed Solutions, Mohanad Abouserie

The Undergraduate Research Journal

We could be swallowing a credit card's weight in plastic every week. Microplastic water pollution is becoming a threat to both humans and aquatic creatures. In this research, microplastic water contamination is discussed, and divergent solutions are proposed. This paper attempts to investigate the causes and effects of such pollution and analyze the current solutions for this issue. The adopted research method is secondary research, where several studies are explored and analyzed. This study explains numerous causes for this issue like cosmetics, cleaning products, factories, and sewage. Consequently, this contamination can negatively impact the organs and metabolisms of the living …

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Aira: An Intelligent Recommendation Agent Application For Movies, Ayesha Anees Zaveri, Ramsha Mashood, Sarama Shehmir, Misbah Parveen, Naveera Sami, Mobeen Nazar Sep 2023

Aira: An Intelligent Recommendation Agent Application For Movies, Ayesha Anees Zaveri, Ramsha Mashood, Sarama Shehmir, Misbah Parveen, Naveera Sami, Mobeen Nazar

Journal of Informatics and Web Engineering

An intelligent Recommendation App has been developed to assist caregivers. This project's primary objective is to assist parents in determining whether a particular movie/cartoon/drama is adequate for their children by providing ratings that will assist them in identifying age-appropriate content. This application will provide reliable evaluations, reviews, and recommendations to parents. Each rating and review are based on fundamental, essential child development principles. Intelligent Recommendation Agent aids families in making intelligent media selections. It provides the most extensive and reliable database of learning ratings, age recommendations, and content evaluations for films, television series, and dramas. In addition, there will be …

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Engaging Learning Experience: Enhancing Productivity Software Lessons With Screencast Videos, Usha Vellappan, Lim Liyen, Lim Su Yin Sep 2023

Engaging Learning Experience: Enhancing Productivity Software Lessons With Screencast Videos, Usha Vellappan, Lim Liyen, Lim Su Yin

Journal of Informatics and Web Engineering

The use of screencast videos can improve the effectiveness of the teaching and learning process, whether it is face-to-face or online. Screencast videos are digital resources that capture the computer screen and create an audio-visual experience, and they can be shared online to aid the learning process. It eliminates the need for educators to repeat information multiple times and creates an uninterrupted personalised learning environment for the students. This method of learning gives students a more personalised sense, as if they were given one-on-one guidance from the educator, with students having access to the educator and receiving immediate feedback during …

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Pathogen-Driven Crispr Screens Identify Trex1as A Regulator Of Dna Self-Sensing During Influenza Virus Infection, Cason R King, Yiping Liu, Katherine A Amato, Grace A Schaack, Clayton Mickelson, Autumn E Sanders, Tony Hu, Srishti Gupta, Ryan A Langlois, Judith A Smith, Andrew Mehle Sep 2023

Pathogen-Driven Crispr Screens Identify Trex1as A Regulator Of Dna Self-Sensing During Influenza Virus Infection, Cason R King, Yiping Liu, Katherine A Amato, Grace A Schaack, Clayton Mickelson, Autumn E Sanders, Tony Hu, Srishti Gupta, Ryan A Langlois, Judith A Smith, Andrew Mehle

Faculty, Staff and Student Publications

Host:pathogen interactions dictate the outcome of infection, yet the limitations of current approaches leave large regions of this interface unexplored. Here, we develop a novel fitness-based screen that queries factors important during the middle to late stages of infection. This is achieved by engineering influenza virus to direct the screen by programming dCas9 to modulate host gene expression. Our genome-wide screen for pro-viral factors identifies the cytoplasmic DNA exonuclease TREX1. TREX1 degrades cytoplasmic DNA to prevent inappropriate innate immune activation by self-DNA. We reveal that this same process aids influenza virus replication. Infection triggers release of mitochondrial DNA into the …

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