Digital Commons Network^™

Non-Receptor Tyrosine Kinases: Their Structure And Mechanistic Role In Tumor Progression And Resistance, Abdulaziz M. Eshaq, Thomas W. Flanagan, Sofie Yasmin Hassan, Sara A. Al Asheikh, Waleed A. Al-Amoudi, Simeon Santourlidis, Sarah Lilly Hassan, Maryam O. Alamodi, Marcelo L. Bendhack, Mohammed O. Alamodi, Youssef Haikel, Mossad Megahed, Mohamed Hassan

School of Graduate Studies Faculty Publications

Protein tyrosine kinases (PTKs) function as key molecules in the signaling pathways in addition to their impact as a therapeutic target for the treatment of many human diseases, including cancer. PTKs are characterized by their ability to phosphorylate serine, threonine, or tyrosine residues and can thereby rapidly and reversibly alter the function of their protein substrates in the form of significant changes in protein confirmation and affinity for their interaction with protein partners to drive cellular functions under normal and pathological conditions. PTKs are classified into two groups: one of which represents tyrosine kinases, while the other one includes the …

Combining Agricultural Agent Training In Forages With Graduate Credit, Garry Lacefield, Jimmy Henning, M Rasnake, C Forsythe, L Davis

IGC Proceedings (1977-2023)

An intensive agent training programme in alfalfa (Medicago sativa L.) production nnd utilisation was initialed in 1990. The training was organised by slate extension forage specialists to meet the needs of agricultural agents. Previous programmes have offered similar training but did nol resull in graduate credit. This unique approach offered intensive training to agents presented by a multidisciplinary learn of scientists. All requirements for graduate credit were met and the course completion resulted in 3 hours of graduate credit. The course has been rated "superior" by students. When properly organised and implemented, intensive agent training can be offered that …

A Grazing Land Conservation Plan, R G. Hendricks

IGC Proceedings (1977-2023)

In a sample planning scenario, a ranching operation in the USA demonstrates a typical conservation problem on grazing lands. Using SCS conservation planning techniques, problems and objectives are identified, resources are inventoried, data are analysed, solutions formulated and conservation practices implemented to solve the resource problem. With use of the economic analysis routine in Grazing Land Applications (OLA) version 1.1 decision suppott software, return on investment was largest when the client installed a combination of rest-rotation grazing, prescribed burning, and initiated a hunting lease programme.

Range Conservation Planning: The Usda- Soil Conservation Service Method, Rhett H. Johnson

IGC Proceedings (1977-2023)

The USDA-Soil Conservation Service has responsibility for providing one-on-one conservation planning assistance with the private rangeland managers of over 160 million ha in the USA. This assistance is provided on voluntary basis at the request of the private land user through a local conservation district. Through SO years of experience, a successful planning process has evolved, known as the Ten Elements Of Conservation Planning. These elements are: (1) provide information, (2) request assistance, (3) develop resource inventories, (4) recognise problems and opportunities, (5) determine objectives, (6) develop and evaluate alternatives, (7) make decisions, (8) document decisions, (9) implement decisions, and …

Use Of Objective Planning Techniques In The Development Of Large Livestock Farm In New Zealand, K I. Lowe

IGC Proceedings (1977-2023)

Limestone Downs is a sheep and beef cattle property of 3200 ha near Port Waikato, and provides funds for the C Alma Baker Trust for "the furtherance of the science of agriculture". A development programme slatted in 1981 transformed the farm from an extensive "station" into an intensive farming operation, lifting animal performance and financial returns. This followed the adoption of well-proven and relatively inexpensive modifications to management. Similar programmes should have realistic goals, and established decision rules with priorities. These should be supported by an appropriate monitoring programme and the use of objective data in decision making.

Interdisciplinary Research: A Vehicle For Meeting The Information Needs Of Grassland Producers, Robert O. Burton Jr, K P. Coffey, J L. Moyer, L W. Lomas, P T. Berends

IGC Proceedings (1977-2023)

Representing the major academic disciplines involved in grassland research • agronomy, animal science and agricultural economics the authors discuss the benefits and pitfalls of interdisciplinary research. Factors discouraging interdisciplinary research include: (1) discipline chauvinism, (2) the time and effort required for communications .and co-ordination, (3) inadequate credit for multiple authorship and (4) importance of disciplinary research. However, link among disciplines are necessary because clientele commercially producing forage need information integrating agronomy, animal science, economics and other disciplines. Benefits of interdisciplinary research are ( I) stimulating highly specialised scientists to plan, perform and interpret their research in the context of whole-farm …

Effect Of Inoculants And Absorbents Incorporated In Grass Silage On Silage Quality, Effluent Production And Animal Performance, Raymond Jones

IGC Proceedings (1977-2023)

Unwilled ryegrass crops (151 kg DM) were enslled in 70-t bunker silos. Crop analysis (g/kg/DM) was water-soluble carbohydrates 153, nitrogen 24.1 and predicted digestibility (DOMD) 0.67. Molassed sugar beet feed pellets were incorporated at a rate of 25 kg/t in the harvested crop with or without inoculant treatment ("Live Systems", MMB, UK), and compared with a control silage with no additive. Absorbent addition with or without inoculant significantly reduced silage pH and ammonia-N compared with the control. Inoculant treatment further increased lactic acid content. Silage effluent production was reduced by up to 33% by absorbent inclusion with effluent DM losses …

The Role Of Efflux Pump Inhibitor In Enhancing Antimicrobial Efficiency Of Silver Nanoparticles And Methylene Blue As An Effective Photodynamic Therapy Agent, Yaran Allamyradov

Masters Theses & Specialist Projects

Efflux pumps are critical active transport systems utilized by cells to expel toxic substances, including antibiotics and photosensitizer complexes, thereby contributing to antimicrobial resistance. Efflux pump inhibitors (EPIs), which are compounds that obstruct the transport of molecules through these pumps, play a pivotal role in enhancing the effectiveness of antimicrobial therapies against pathogens. This study investigates the effects of the EPI reserpine on the photodeactivation rate of pathogens when used in conjunction with silver nanoparticles (Ag NPs) and methylene blue (MB), a common photosensitizer.

Our research reveals that the application of reserpine, in combination with Ag NPs and MB, leads …

Contaminant Transport Mechanisms And Source Tracking In Karst Groundwater Systems Under Agricultural Land Use, Shreya Pandey

Masters Theses & Specialist Projects

Karst areas in general face severe groundwater contamination problems that can degrade their water quality. In comparison to other landscapes, groundwater within karst regions is more susceptible to contamination. The situation gets worse when agriculture is practiced in these karst regions, because the nutrients and bacteria like nitrates and E. coli (Escherichia coli) are released into the groundwater systems which contaminate the water quality of those karst groundwater systems. This research aims to study the impacts of these contaminants, specifically nitrates and E. coli., by identifying the contaminant transport mechanisms and source tracking of these contaminants in the groundwater under …

Comprehensive Climate Vulnerability Assessment Of A Regional Karst Landscape For Hazard Mitigation Planning, Kara Brunot

Masters Theses & Specialist Projects

Climate change is the global phenomena affecting all sectors of society by creating conditions more conducive for the occurrence of extreme weather events. It is projected that the intensity and frequency of events will increase. Flooding, in particular, is projected to increase in frequency due to more intense precipitation events. Karst landscapes are especially vulnerable to climate change impacts because of their unique hydrology and geology. Karst flooding is most likely to occur from prolonged or intense rain events, which climate change will likely make more feasible. Areas are disproportionately affected by climate change due to population demographics and environmental …

Assessing Regional Responsibility Of Plecoptera (Stoneflies) Across Two U.S. Fish And Wildlife Service Regions, Josie Griffith

Masters Theses & Specialist Projects

Developing an objective metric to designate taxa that are the responsibility of the region is imperative for the proper allocation of conservation funding. This project focused on stoneflies (Order Plecoptera), an imperiled group of aquatic insects at the global scale, in two U.S. Fish and Wildlife Service regions. At the regional scale, a baseline designation of Regional Species of Greatest Conservation Need (RSGCN) was applied to each species where their range included at least 75% of states within either the Midwestern or Northeastern regions. Two sets of data were accumulated for each RSGCN. One, distributional information was collected from valid …

Landuse And Microplastic Transport In Karst Groundwater Of South-Central Kentucky, Katie Norman

Masters Theses & Specialist Projects

Groundwater in karst areas is susceptible to contamination from various sources of pollution. Microplastics are a prevalent source of pollution entering groundwater. This study examines karst groundwater in three areas of investigation. One point of interest is an area that is impacted by urban activities, the Lost River Groundwater Basin, which includes water drainage from the City of Bowling Green, Kentucky. Another study location is Great Onyx (GO) Spring, which is a part of the Great Onyx Groundwater Basin located in Mammoth Cave National Park, Kentucky, and that is relatively unimpacted by urban activities. The third point of interest is …

Lactoferrin And Lysozyme To Promote Nutritional, Clinical And Enteric Recovery: A Protocol For A Factorial, Blinded, Placebo-Controlled Randomised Trial Among Children With Diarrhoea And Malnutrition (The Boresha Afya Trial), Ruchi Tiwari, Kirkby Tickell, Emily Yoshioka, Joyce Otieno, Adeel Shah, Barbra Richardson, Lucia Keter, Maureen Okello, Churchil Nyabinda, Indi Trehan

Paediatrics and Child Health, East Africa

Introduction: Children with moderate or severe wasting are at particularly high risk of recurrent or persistent diarrhoea, nutritional deterioration and death following a diarrhoeal episode. Lactoferrin and lysozyme are nutritional supplements that may reduce the risk of recurrent diarrhoeal episodes and accelerate nutritional recovery by treating or preventing underlying enteric infections and/or improving enteric function.

Methods and analysis: In this factorial, blinded, placebo-controlled randomised trial, we aim to determine the efficacy of lactoferrin and lysozyme supplementation in decreasing diarrhoea incidence and improving nutritional recovery in Kenyan children convalescing from comorbid diarrhoea and wasting. Six hundred children aged 6–24 months with …

Effects Of A Protection Zone In A Reaction-Diffusion Model With Shifting Bounded Habitat And Allee Effect., Davis Henderson

Electronic Theses and Dissertations

We consider a reaction-diffusion equation that models a population in a shifting bounded habitat with a protection zone and the Allee effect. We assume that the population growth function exhibits the strong Allee effect and has a positive integral within the protection zone (indicating population persistence) and a negative integral in the surrounding patches (indicating population decay). We prove that the existence of steady-state solutions to this system depends on the length of the protection zone. It is demonstrated that there exists some value H* such that, for a protection zone of size H*, there exists a solution and, for …

Value Of Macroalgae As Habitat In A Eutrophic Coastal Bay, Dominika Polchowska

Theses, Dissertations and Culminating Projects

Eutrophication is a phenomenon caused by changes in nutrient loading that results in harmful algal blooms, an overgrowth of macroalgae, altered aquatic benthic invertebrate communities, and loss of ecosystem functions. Barnegat Bay, NJ is a highly eutrophic system that has experienced a substantial loss of seagrass beds with subsequent expansion of drift macroalgae. Although considered poor quality, these algal beds represent valuable habitat for many benthic invertebrates. This research assesses the value of macroalgae as a habitat for macrofauna in regions where macroalgae are the dominant “vegetation.” Benthic drift algal samples were collected during June and August 2023 to reflect …

An Interdisciplinary Analysis Of Freshwater Wetlands With A Focus On Ecosystem Functions And Services, Michael Viteritto

Theses, Dissertations and Culminating Projects

Wetlands are one of the most productive ecosystems on Earth, though they only occupy a very small portion of the planet’s surface. They are highly sensitive ecosystems that have been undergoing an extended period of loss because of anthropogenic stress. Freshwater wetlands number among the most numerous on the planet, and in the United States they make up the overwhelming majority of wetland area. Geographically isolated wetlands (GIWs) are not directly connected to other surface water in a watershed. Freshwater wetlands provide a number of beneficial ecosystem services including climate control, erosion protection, nutrient removal and storage, flood control, food …

Unraveling Wetland Ecology: The Effect Of Abiotic Heterogeneity And Habitat Size On Wetland Plant Diversity In The Piedmont, Gregory T. Gilmore

All Theses

Ecosystems around the world are seeing an unprecedented decline in biodiversity. However, to better prevent this decline we cannot only understand the drivers of biodiversity loss, but also the factors that support diversity. Traditional ecological hypotheses such as the Habitat Heterogeneity Hypothesis (HHH) and the Theory of Island Biogeography (TIB) have provided frameworks for understanding biodiversity drivers. However, recent research suggests a more nuanced relationship between heterogeneity, habitat size, and diversity than previously thought. This study looks to bridge existing research gaps by examining the ecologically and conservational important habitat of wetlands. Specifically, the study focuses on the plant diversity …

Caught On Camera: Evaluating Wood Duck (Aix Sponsa) Cavity Occurrence And Trapping Efficiency, Cindy L. Von Haugg

All Theses

Wood ducks (Aix sponsa) garner significant ecologic and economic importance as the second most harvested waterfowl species in two of the four migratory flyways in North America, but the accuracy of population monitoring, relative to other duck species, is stifled by the wood duck’s secretive nature and nesting habitat. As an alternate, population models would improve current assessments, but more data on the demographic vital rates of cavity-nesting wood ducks is needed. I aimed to help bridge this knowledge gap by developing a method to increase data collection efficiency, and with it, accomplish two objectives: 1) Calculate the relative abundance …

Chain-Of-Exemplar: Enhancing Distractor Generation For Multimodal Educational Question Generation, Haohao Luo, Yang Deng, Ying Shen, See-Kiong Ng, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Multiple-choice questions (MCQs) are important in enhancing concept learning and student engagement for educational purposes. Despite the multimodal nature of educational content, current methods focus mainly on text-based inputs and often neglect the integration of visual information. In this work, we study the problem of multimodal educational question generation, which aims at generating subject-specific educational questions with plausible yet incorrect distractors based on multimodal educational content. To tackle this problem, we introduce a novel framework, named Chain-of-Exemplar (CoE), which utilizes multimodal large language models (MLLMs) with Chain-of-Thought reasoning to improve the generation of challenging distractors. Furthermore, CoE leverages three-stage contextualized …

Interpretable Tensor Fusion, Saurabh Varshneya, Antoine Ledent, Philipp Liznerski, Andriy Balinskyy, Purvanshi Mehta, Waleed Mustafa, Marius Kloft

Research Collection School Of Computing and Information Systems

Conventional machine learning methods are predominantly designed to predict outcomes based on a single data type. However, practical applications may encompass data of diverse types, such as text, images, and audio. We introduce interpretable tensor fusion (InTense), a multimodal learning method training a neural network to simultaneously learn multiple data representations and their interpretable fusion. InTense can separately capture both linear combinations and multiplicative interactions of the data types, thereby disentangling higher-order interactions from the individual effects of each modality. InTense provides interpretability out of the box by assigning relevance scores to modalities and their associations, respectively. The approach is …

Cover-Crop Effects On Near-Surface Soil Properties Over Time In The Lower Mississippi River Valley, Cooper Fanning

Graduate Theses and Dissertations

Human population growth and climate change are present stressors that continue to put pressure on current agricultural production systems, where typical row-crop agricultural practices can negatively impact soil health. Extensive use of cover crops (CC) to increase soil health remains widely unrealized. Soil health in Arkansas is a major concern for sustaining agricultural output, therefore research into CC implementation across Arkansas to maintain or improve soil health is needed. The objective of this study was to evaluate the effects of CC (i.e., with and without CC) across various physical, hydraulic, biological, and chemical soil indicators in the Lower Mississippi River …

Struvite Effects On Greenhouse Gas Emissions From Flood- And Furrow-Irrigated Rice In The Greenhouse, Chandler Arel

Graduate Theses and Dissertations

Over time, as the influences of climate-change and declining, mineable, global phosphorus (P) reserves begin to impact agricultural production systems, alternative fertilizer sources and management practices, such as struvite (MgNH₄PO₄ · 6H₂O) and furrow-irrigation, will be necessary to accommodate nutrient and water demands. The precipitation and use of struvite as a fertilizer-P source could reduce environmental damages caused by nutrient-rich wastewater streams, supplement domestic P supply, and improve the sustainability of flood-, and furrow-irrigated rice production by reducing greenhouse gas emissions. The study of struvite from both chemical and electrochemical precipitation processes is well documented, …

Transforming Grassland Conservation: Challenges And Opportunities Across Law, Policy, And Human Dimensions, Conor D. Barnes

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Great Plains social-ecological systems are facing growing pressure from complex, ‘wicked’ problems. Addressing these problems will require integrating ecological resilience and complex systems thinking concepts into our legal framework in order to better reflect the changing ecological reality of the Great Plains and promote flexibility and adaptability in the face of that change. In this dissertation, I examine how past and present policy priorities have affected social-ecological systems on the Great Plains, and how ecological resilience and complex systems thinking might be applied to grassland management policy. In Chapter 2, I examine the rapid progress made in the adoption of …

Further Developing Drought Early Warning Information Systems Using Mixed-Methods And Multiple Streams Of Data, Caily Claire Schwartz

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Drought is a complex phenomenon with varying degrees of impacts and monitoring methods. No drought is alike, creating a challenge for both water managers and communities. No area is immune to a drought. Due to the cyclical nature of drought events, clear information to those impacted is necessary to reduce risk and move towards proactive responses, as opposed to reactive responses. To better provide communication and mitigation tools, Drought Early Warning Information Systems (DEWIS) have been developed in various regions and contexts. To improve early warning, an understanding of the end user’s perceptions of risk, and the applicability of data …

Applying Circuit Theory To Describe Changes In Structural Landscape Connectivity In Response To Wildfire, Christian Ross Nielsen

School of Natural Resources: Dissertations, Theses, and Student Research

Understanding and conserving ecological connectivity is critical to the preservation of vulnerable landscapes. Circuit theory, in which landscapes are imagined as circuit boards with varying resistances to the flow of current, is being increasingly used to model spatially explicit connectivity of landscapes and to inform land management and conservation decision-making. Utilizing continuous, quantitative estimates of percent cover by five land cover functional groups to create a conductance surface, this study expanded upon an established application of circuit theory that used the open-source software Circuitscape to model species-agnostic, omnidirectional connectivity. This model was automated using Python to create time-series connectivity maps …

Occurrence, Inputs, And Ecological Significance Of Antibiotics And Pharmaceuticals In Western Nebraska Streams, Katelyn F. Glause

School of Natural Resources: Dissertations, Theses, and Student Research

Few emerging environmental contaminants are as concerning as antibiotics. Human and animal health benefits greatly from the prudent use of antibiotics, yet we give little thought to environmental release of these biologically active compounds. Environmental occurrence of these and other pharmaceutical compounds must be measured in different environmental compartments such as municipal wastewater and in the vicinity of large animal feeding operations to understand potential effects. This study reports the results of a monitoring study in western Nebraska, with a large population of livestock and smaller but more concentrated population of humans, comparing the relative environmental concentrations and loading from …

Analysis Of Drought-Flood Abrupt Alternation Events And Their Impacts In Kenya, Betty Makena

School of Natural Resources: Dissertations, Theses, and Student Research

Drought-Flood Abrupt Alternation (DFAA) is a compound disaster event that refers to the abrupt shift of extreme drought events to extreme floods resulting in exacerbated impacts on already vulnerable communities and hindering their coping abilities. This study aimed to analyze drought-flood abrupt alternation events and their impacts in Kenya. The first chapter aimed to understand historical drought events in the Greater Horn of Africa and their impacts, while drawing comparisons with the recent 2020-2022 drought period, referred to as the ‘triple dip La Niña’. Datasets used in this study include the Climate Hazards Group InfraRed Precipitation with Station (CHIRPS), Normalized …

Remotely Sensed Early Warning Of Algal Blooms In An Eastern Nebraska Reservoir: A Comparison Of Temporal And Spatial Indicators, Mercy Kipenda

School of Natural Resources: Dissertations, Theses, and Student Research

Cyanobacterial harmful algal blooms (CyanoHABs) detrimentally affect human, animal, and ecosystem health. Remotely sensed early warning systems for cyanoHABs in inland lakes could contribute to more proactive water quality monitoring and help mitigate negative impacts. Advances in freely available remote sensing imagery, with finer spatial, temporal, and spectral resolutions, present new opportunities for the development and comparative analysis of methods to detect sudden deterioration in lake water quality. In this thesis, I compared and tested for temporal and spatial early warning signals of cyanoHABs in field-based and remotely sensed datasets from 2019 to 2023 in Pawnee Lake in southeast Nebraska, …

Impacts Of Invasive Carp And Their Population Dynamics On Fish Communities In The Missouri River, Joshua F. Kocik

School of Natural Resources: Dissertations, Theses, and Student Research

Invasive Carp species: Silver Carp Hypophthalmichthys molitrix, Bighead Carp Hypophthalmichthys nobilis, Grass Carp Ctenopharyngodon idella, and Black Carp Mylopharyngodon piceus have both potential and realized abilities to negatively impact native species. Specifically, Bighead Carp and Silver Carp as filter feeders have been theorized to be detrimental not only to adult filter-feeding species, but to many fish which rely on plankton and algae in their early-life stages. The impact of Invasive Carp on the overall fish community remains underexplored. The fish communities below Gavins Point Dam (Invasive Carp present) and Fort Randall Dam (Invasive Carp absent) afford the …

Spatiotemporal Plasticity In Reproductive Readiness And Recruitment Of Ichthyoplankton Of Invasive Silver Carp Along A Western Invasion Front, Jessi L. Urichich

School of Natural Resources: Dissertations, Theses, and Student Research

Individuals of invasive species at the edge of their invasion distribution may exhibit enhanced reproductive capacity and phenotypic plasticity leading to accelerated range expansion. Environmental conditions in highly fluctuating environments at distribution edges may either promote or hinder such reproductive readiness and phenotypic plasticity. Dynamic habitat conditions and periodic disturbances experienced in prairie streams, such as drought (e.g., low-flow, high water temperatures), may potentially reduce suitable spawning environments and ichthyoplankton recruitment of invasive Silver Carp, potentially slowing range expansion or enabling management strategies that reduce abundance in the absence of a reproducing population. Female Silver Carp batch fecundity, Gonadosomatic Index …