Digital Commons Network^™

Evaluation Of The Stability Of Argan Oil Nanoemulsions Formulated And Optimized Through Experimental Design For Dermatological Applications, Yousra Mdarhri, Ikram Bouziane, Narjisse Mokhtari, Lama Rissouli, Ahmed Touhami, Fakhita Touhami, Mohamed Chabbi

Physics & Astronomy Faculty Publications

Argan oil is a highly sought-after natural product renowned for its therapeutic and rejuvenating properties. This study focused on harnessing its dermatological bioactivity by developing stable nanoemulsions through a simple low-energy method using a single non-ionic surfactant. The composition and properties of Argan oil were analyzed using High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), and quality indexes, adhering to international standards. The effect of system composition on stability was evaluated using a pseudo-ternary phase diagram and Phase Inversion Composition (PIC) emulsification technique. Optimal process parameters for producing stable nanoemulsion were determined through Response Surface Methodology (RSM) analysis. The resulting nanoemulsions …

Biochar For Soil Amendment: Applications, Benefits, And Environmental Impacts, Ujjwal Pokharel, Gururaj Neelgund, Ram L. Ray, Venkatesh Balan, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

The excessive use of chemical fertilizers results in environmental issues, including loss of soil fertility, eutrophication, increased soil acidity, alterations in soil characteristics, and disrupted plant–microbe symbiosis. Here, we synthesize recent studies available from up to 2025, focusing on engineered biochar and its application in addressing issues of soil nutrient imbalance, soil pollution from inorganic and organic pollutants, soil acidification, salinity, and greenhouse gas emissions from fields. Application of engineered biochar enhanced the removal of Cr (VI), Cd²⁺, Ni²⁺, Zn²⁺, Hg²⁺, and Eu³⁺ by 85%, 73%, 57.2%, 12.7%, 99.3%, and 99.2%, …

Pygoscelis Penguins Prefer Different Oceanographic And Terrestrial Habitats During The Austral Summer, Katherine L. Gallagher, Rachel Herman, Katherine Walton, Michael S. Dinniman, Heather J. Lynch

OES Faculty Publications

Pygoscelis penguins interact with both terrestrial and marine environments, especially during the austral summer when they raise their chicks. Accessible ice-free ground spaces serve as locations for penguins to build colonies and successfully raise chicks while the surrounding marine environment serves as the foraging grounds for adult birds. Penguins must be able to navigate through the waters around their colonies to forage for Antarctic krill (Euphausia superba), their primary prey during the austral summer. Krill, whose distributions are driven partially by the surrounding physics and partially by their behaviors, must also be plentiful in the waters near the …

From Wind To Whales: Potential Hydrodynamic Impacts Of Offshore Wind Energy On Nantucket Shoals Regional Ecology, Eileen E. Hofmann, Jeffrey R. Carpenter, Qin J. Chen, Josh T. Kohut, Richard L. Merrick, Erin L. Meyer-Gutbrod, Douglas P. Nowacek, Kaustubha Raghukumar, Nicholas R. Record, Kelly Oskvig

OES Faculty Publications

The National Academy of Sciences, Engineering, and Medicine convened a committee in June 2023 to assess the potential hydrodynamic and ecological impacts from offshore wind energy development in the Nantucket Shoals region, with particular attention to impacts on the critically endangered North Atlantic right whale (Eubalaena glacialis) that forages on zooplankton aggregations in the region. The assessment suggested that the effects of offshore wind energy development will be difficult to distinguish from the effects of natural variability and climate change in this region. The Consensus Study Report recommendations highlight observational and modeling studies that will advance understanding of …

Microbial Mats In Dinosaur Ichnocoenoses, Nora Noffke, Paul C. Murphey, Roger C. Buntin, Martin G. Lockley

OES Faculty Publications

Until now, the significance of microbial mats in preservation of dinosaur tracks and in reconstructing the palaeoenvironment in which dinosaurs roamed was rarely studied. Dinosaur tracks are commonly found close to ancient aquatic bodies where moist sediment had once allowed footstep registration. At such sites, epibenthic or endobenthic microbial mats may have developed as well and may have led to exquisite track preservation. Microbial mats in coastal, lacustrine or flood plain environments cause ‘microbially induced sedimentary structures—MISS’, which are micobialites found in sandy or evaporitic settings. The microbial structures record environmental parameters including meteorological conditions that existed at the time …

Successful Eastern Oyster (Crassostrea Virginica) Recruitment On Intertidal Artificial Substrates In Virginia, Usa, Rochelle D. Seitz, Kathleen E. Knick, Emily Suchonic, Amanda Pysher

OES Faculty Publications

Declines of eastern oyster (Crassostrea virginica) populations and scarcity of natural oyster shell necessitate quantifying the effectiveness of artificial oyster reef substrates over varying environmental conditions. Oyster castles are often used in intertidal areas with moderate wave energy; however, new concrete, natural-looking substrates, GROW Reef Tiles, are now available. Eastern oyster recruitment and size on oyster castles (OC) and GROW Reef Tiles (GT), with 27% higher surface area on OC, were assessed three times over 25 months in locations with varying salinity. Four sites in the Chesapeake Bay region were examined: Cherrystone Inlet, Mockhorn Bay, Elizabeth River, and …

Organic Geochemical Evidence For Life In Archean Rocks Identified By Pyrolysis-Gc-Ms And Supervised Machine Learning, Michael L. Wong, Anirudh Prabhu, Conel O'D. Alexander, H. James Cleaves Ii, George D. Cody, Grethe Hystad, Marko Bermanec, Wouter Bleeker, C. Kevin Boyce, Andrea Corpolongo, Andrew D. Czaja, Souvik Das, Robert R. Gaines, Daniel D. Gregory, John A. Jaszczak, Emmanuelle J. Javaux, Jaganmoy Jodder, Andrew H. Knoll, Martin Van Kranendonk, Katie M. Maloney, Nora Noffke, Robert Rainbird, Emersyn Slaughter, Eva E. Stüeken, Roger E. Summons, Frances Westall, Jasmina Wiemann, Shuhai Xiao, Robert M. Hazen

OES Faculty Publications

Throughout Earth’s history, organic molecules from both abiogenic and biogenic sources have been buried in sedimentary rocks. Most of these organic molecules have been significantly altered by geologic processes through deep time. Nonetheless, the nature and distribution of those ancient fragmentary organic remains have the potential to reveal diagnostic biomolecular information after billions of years of burial. Here, we analyzed 406 fossil, modern biological, meteoritic, and synthetic samples using pyrolysis gas chromatography and mass spectrometry. We explored these analytical data via supervised machine-learning methods to discriminate samples of biogenic vs. abiogenic origin, plant vs. animal phylogenetic affinity, and photosynthetic vs. …

Synthesis And Characterization Of A Biobased Polymer From Tung Oil And Pine Rosin & Characterization Of Polyhydroxybutyrate., Arijanet P. Osumah

College of Graduate Studies: Theses & Dissertations

This thesis presents two independents but thematically aligned research projects focused on the development and evaluation of sustainable polymers. The first involves the synthesis and characterization of a biobased polymer derived from tung oil and pine rosin. Tung oil, which is a triglyceride was chemically modified to produce tung oil diglyceride (TDG), which subsequently reacted with abietic acid-rich pine rosin to yield tung oil abietate (TOA), a biobased monomer. The TOA monomer was polymerized with butyl methacrylate (BMA) and divinylbenzene (DVB) using di-tert-butyl peroxide (DTBP) as a thermal initiator. The resulting polymer was thoroughly characterized using Fourier transform infrared spectroscopy …

Assessment And Health Benefit Of Vitamin C Using A549 Cell, Yetunde Adepoju

College of Graduate Studies: Theses & Dissertations

Vitamin C (ascorbic acid) is a vital micronutrient recognized for its antioxidant capacity and essential bodily functions, such as collagen formation, neurotransmitter activity, and regulation of the immune system. This study explores how vitamin C can protect and potentially heal cells under oxidative stress and inflammation, using A549 cells, a human lung epithelial cell line, as the model system. The cells were exposed to varying concentrations of vitamin C dissolved in water, DMSO, and 5% DMSO. To assess the outcome, cell viability was measured with an MTT assay. In addition, the expression of key genes related to oxidative stress and …

Synthesis And Assessment Of Biobased Acrylated Epoxidized Soybean Oil Resins For Stereolithography 3d Printing Of Microfluidic Devices, Natalie S. Romero Figueroa

College of Graduate Studies: Theses & Dissertations

This research focuses on the development and characterization of a biobased photocurable resin synthesized from soybean oil for use in stereolithography (SLA) 3D printing of microfluidic devices. The study explores a sustainable alternative to petroleum-based resins by performing an acrylation reaction on epoxidized soybean oil (ESO) to produce acrylated epoxidized soybean oil (AESO), which was then formulated into a photocurable resin with the addition of a photo initiator. The fabrication process involved designing microfluidic molds in SolidWorks and printing them using an Elegoo Mars 4 SLA printer under various exposure and layer thickness parameters. The printed samples consisted of microchannels …

Ai Characterisations And Their Legal Implications, Jerrold Tsin Howe Soh

Research Collection Yong Pung How School Of Law

This chapter examines the difficult legal characterisation problems that artificially intelligent systems raise and explores how different characterisations of artificial intelligence (AI) shape practical legal outcomes. Three reasons are offered for the legal difficulty with characterising AI. First, answers to characterisation problems are inherently subjective and perspective-driven, particularly when the subject is an intangible technological system. Second, AI technology is especially difficult to define since the field typically proceeds on inexact anthropomorphic metaphors. Third, AI characterisation problems raise difficult sub-problems, particularly in determining how autonomous an AI system is. The chapter thus argues that a range of plausible AI characterisations …

The Climate-Biodiversity-Pollution Nexus: The Pricing Of Environmental Credit Risks For European Industrial Polluters, Dominik Hirschbühl, Andrej Ceglar, Theodor Cojoianu, Tina Emambakhsh, Yifan Qi, Caterina Rho, Elsie Hu, Marco Petracco, Fabrizio Biganzoli, Alfred De Jager, Laura Garcia Herrero, Andrea Mandrici, Carlo Pasqua

Research Collection College of Integrative Studies

This study examines how euro area banks factor pollution-induced biodiversity risks into lending decisions, using data from 832 banks and 5,000 major polluters. Our results show that banks are increasingly pricing these risks by adjusting loan-to-value ratios and interest rates. Banks adjust lending conditions in line with EU pollution and biodiversity protection legislation, particularly for companies with large pollution footprints near biodiversity-protected areas or those contributing to Environmental Quality Standards failures of downstream surface waters. The former is driven primarily by banks’ adoption of biodiversity policies and public commitments to the Equator Principles, while the latter is a result of …

Comprehensive Analysis Of Environmental Particulate Matter: Chemical Composition And Microbial Assessment, Uyen T. L. Le

Theses and Dissertations (Comprehensive)

Rapid industrialization and population growth have contributed to a decline in air quality, with particulate matter (PM) posing particular concern. PM originates from both natural and human sources and often contains toxic chemicals and microorganisms, including potential pathogens. Inhalation of PM is linked to respiratory and cardiovascular diseases, underscoring the need to characterize better its chemical and biological composition in understudied region - Waterloo, Ontario, Canada. The present thesis is a culmination of three main parts. Part 1 will describe the use of the dithiothreitol (DTT) assay to quantify the oxidative potential of PM through DTT consumption of redox-active field …

Integrating Indigenous Values And Community Strengths To Achieve Indigenous Food Sovereignty And Community Well-Being In The Ka’A’Gee Tu First Nation, Northwest Territories, Jennifer K. Temmer

Theses and Dissertations (Comprehensive)

Northern Indigenous communities face disproportionate impacts from interconnected challenges related to climate change, food security, health, and cultural preservation, that threaten traditional food systems and practices. While there is a growing recognition of the importance of community-driven solutions, existing frameworks fail to integrate Indigenous values and local priorities effectively. This research addresses this gap by exploring how the Ka’a’gee Tu First Nation (KTFN) is responding to these crises through climate change adaptation efforts focused on food system sustainability as a pathway to self-sufficiency and community well-being. To contribute to these efforts, this dissertation uses Participatory Action Research to facilitate community-driven …

The Reliability Gap: How Traditional Search Engines Outperform Artificial Intelligence (Ai) Chatbots In Rosacea Public Health Information Quality, Houston C. Nelson, Morgan T. Beauchamp, April A. Pace

Department of Medicine Faculty Publications

Background: The internet has become a primary source of health information for the public, with important implications for patient decision-making and public health outcomes. However, the quality and readability of this content vary widely. With the rise of generative artificial intelligence (AI) tools such as ChatGPT and Gemini, new challenges and opportunities have emerged in how patients access and interpret medical information.

Objective: To evaluate and compare the quality, credibility, and readability of consumer health information provided by traditional search engines (Google, Bing) and generative AI platforms (ChatGPT, Gemini) using three validated instruments: DISCERN, JAMA Benchmark Criteria, and Flesch-Kincaid Readability …

Design And Synthesis Of Organocatalyts For Efficient Decontamination Of Organophosphate-Based Nerve Agents And Pesticides, Emmanuel Kingsley Darkwah

Doctoral Dissertations

Exposure to organophosphate-based nerve agents and pesticides poses significant health and security threats to civilians, soldiers, and first responders. Despite extensive efforts to develop chemical detoxification agents for use in topical applications on exposed skin surfaces and for intravenous injections, there remains an unmet need for effective, non-hazardous decontaminating agents. The current state-of-the-art decontaminating agent, Dekon-139 (2,3-butanedione oxime, potassium salt), exhibits adverse effects when applied to the skin.

In this study, we designed and synthesized pharmaceutically relevant aminoguanidine-derived aldimines that are relatively non-toxic and substantially more effective at decontaminating nerve agents and pesticides compared to existing agents, and they act …

Sources Of Underwater Noise, Christine Erbe, Alec J. Duncan, Alexander Gavrilov, Montserrat Landero, Robert D. Mccauley, Iain Parnum, Evgeny Sidenko, Chandra Salgado-Kent, Evgeny Sidenko

Research outputs 2022 to 2026

The marine soundscape, whether in coastal areas or the deepest ocean, in the tropics or at the poles, contains a myriad of sounds. Sounds may be grouped by their origin into geophony (e.g., wind, precipitation, waves, earthquakes, volcanoes, and ice), biophony (e.g., invertebrates, fishes, and marine mammals), and anthropophony (e.g., port construction, mineral and hydrocarbon exploration and production, renewable energy installation, and shipping). This chapter gives a brief overview of the geophony and biophony, and then focuses on the anthropophony. The sounds of boats and ships of various types, marine seismic surveys, drilling, dredging, pile driving, windfarms, geotechnical site investigations, …

Weathering And Beyond: Leveraging Mathematical Modeling To Simulate Erosion In Digital Media, Fiona Irving-Beck

Scripps Senior Theses

How might we bring an idea to life from both a mathematical and an artistic perspective? Within Weathering, I use imagery of environmental erosion to explore the differences between physical and digital forms of representation. I created a physical painting of an abandoned copper mine, digitized the work, and then used a mathematical model to digitally “erode” it, which I re-translated into paintings. While the explicit texture present in physical work speaks best to my practice/intent, the mathematical framework that is the basis for my digital work affords a powerful mode of temporal flexibility. Used in conjunction, these two …

Navigating Online Perceptions Of Offshore Wind On Social Media: Facebook Discussions On Recent Whale Strandings, Giselle Hausmann

Open Access Master's Theses

The Biden-Harris administration implemented a goal to achieve 30 GW of offshore wind energy by 2030 (US Department of Interior, 2021). The rapid increase in offshore wind activity on the East Coast, combined with NOAA’s declared unusual mortality event in 2016/2017, has sparked a discussion about offshore wind being a potential cause of whale deaths. This paper aims to analyze the discourse on offshore wind and whales through a content analysis of Facebook comments. Facebook pages from Massachusetts (The New England Aquarium), Rhode Island (Rhode Island DEM), New York (The Atlantic Marine Conservation Society), New Jersey (Marine Mammal Stranding Center), …

The Bodhi App: A Post-Trauma Self-Regulation App For People With Intellectual And Developmental Disabilities, Liam Cannon

Open Access Master's Theses

People in the United States living with intellectual and developmental disabilities (I/DD) often experience trauma at a disproportionate rate. Due to societal and personal barriers, individuals with I/DD have problems with gaining access to therapy, thus often having to live with the negative effects of their untreated trauma. The effects of untreated trauma can cause severe impairment which affects a person’s quality of life and emotional, social, and physical development.

Post-trauma self-regulation is a way of doing activities to regulate one’s emotions to help cope with the negative effects of trauma. It has been shown as an effective method of …

From Lawns To Life: Landscaping For Biodiversity On Mason’S Island, Margit Burgess

Open Access Master's Theses

The collapse of biodiversity is an existential threat to life on Earth. Residential landscapes, dominated by open lawns maintained in turfgrass, do not support biodiversity. In the United States, turfgrass has replaced native landscapes in over 40 million acres, with 500 square miles added each year (Tallamy, 2019). Of the 78% of the U.S. land that is privately owned, approximately 135 million acres - nearly twice the size of all national parks combined - are residential (Milesi et al., 2005). With a shift in private landscape management, this land could present a largely untapped opportunity for biodiversity restoration and social …

Investigating The Effectiveness Of Best Management Practices In Reducing Fecal Bacteria In Narrow River, Rhode Island, Katherine Thompson

Open Access Master's Theses

Fecal bacterial contamination shapes how communities manage and use estuarine waters, with consequences for ecosystem health and public access. In Rhode Island's Narrow River, elevated concentrations of fecal coliforms and enterococci have restricted shellfishing for decades despite ongoing management efforts. From 2004 to 2018, local organizations implemented Best Management Practices (BMPs) to address water quality challenges, yet their effectiveness remains incompletely understood. This study analyzes three decades of monitoring data using linear regression, generalized additive models, and Before After Control Impact methods to evaluate BMP effectiveness and identify key drivers of contamination. Linear regression revealed spatially variable trends, with bacterial …

El Maíz Del Abuelo: Fidel Márquez Sanchez’S Legacy And Mexico’S Historical Maize Agriculture, Lucia Marquez-Uppman

Scripps Senior Theses

The Green Revolution was an era of scientific development in productive agricultural methods and technologies in the mid-twentieth century. High-yielding seed varieties, artificial fertilizers, irrigation infrastructure, pesticides, and herbicides all developed from this period. Texcoco, Mexico was the center of much of the Green Revolution's education and research from the 1940s onward at the Autonomous University of Chapingo, a prestigious agricultural school, with funding from the US-based philanthropic Rockefeller Foundation. Powerful consequences in the globe's agriculture emerged from the Green Revolution, including the production of maize, a staple crop in Mexico, especially for Indigenous and campesino populations. My abuelo, Fidel …

Securing The Internet Of Wetland Things (Iowt) Using Machine And Deep Learning Methods: A Survey, Guma Ali, Wamusi Robert, Maad M. Mijwil, Malik Sallam, Jenan Ayad

Mesopotamian Journal of Computer Science

Wetlands are essential ecosystems that provide ecological, hydrological, and economic benefits. However, human activities and climate change are degrading their health and jeopardizing their long-term sustainability. To address these challenges, the Internet of Wetland Things (IoWT) has emerged as an innovative framework integrating advanced sensing, data collection, and communication technologies to monitor and manage wetland ecosystems. Despite its potential, the IoWT faces substantial security and privacy risks, compromising its effectiveness and hindering adoption. This survey explores integrating machine learning (ML) and deep learning (DL) techniques as solutions to address the security threats, vulnerabilities, and challenges inherent in IoWT ecosystems. The …

Development And Construction Of New Scanning Antennas With High Remote Sensing Capability For Wireless Communication Systems In The Millimeter Wavelength Range, Nagham Habeeb Shakir, Sarah R. Hashim, Ahmed Sileh Gifal, Ahmed Dheyaa Radhi, Alaa G.K. Alshami, Rusul Mansoor Alamri, Hussein Mohammed Ali

Mesopotamian Journal of Computer Science

In this paper, geometric methods and wave optics were used to calculate the basic profiles and characteristics of the lens antennas.  The planar reflector arrays were assembled using an iterative method with multiple forward and inverse Fourier transform calculations.  Three-dimensional electromagnetic modeling was performed in CST Microwave Studio software to evaluate the technical parameters of the designed antennas. Measurements of the characteristics of fabricated prototypes of far-field scanning antennas were performed using a custom-designed experimental setup. This study focuses on the analysis and development of scanning antennas for use in millimeter-wave wireless communication systems. The researchers aim to develop a …

Agentic Ai-Enhanced Virtual Reality For Adaptive Immersive Learning Environments, Indra Kishor, Udit Mamodiya, Mohammed Almaayah, Amer Alqutaish, Rami Shehab, Theyazn H. H. Aldhyani

Mesopotamian Journal of Computer Science

Immersive learning using Virtual Reality (VR) has gained prominence for delivering experiential, engaging education. However, most VR learning environments lack real-time adaptability, personalization, and cognitive responsiveness. This study presents an Agentic AI-enabled VR framework that autonomously adjusts pedagogical content, interaction style, and challenge level based on learner behavior, emotions, and performance feedback. The proposed system integrates a reinforcement learning-based agent with a virtual reality module to form an intelligent tutor capable of independent decision-making. A neuro-symbolic model processes multi-modal feedback (gesture, speech, gaze, performance) to determine context-aware pedagogical strategies. The system employs a self-evolving curriculum logic that adapts in real …

S-Methyl Cysteine Sulfoxide And Its Potential Role In Human Health: A Scoping Review, Caroline R. Hill, Alex Haoci Liu, Lyn Mccahon, Liezhou Zhong, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Research outputs 2022 to 2026

Higher intakes of cruciferous and allium vegetables are associated with a lower risk of cardiometabolic-related outcomes in observational studies. Whilst acknowledging the many healthy compounds within these vegetables, animal studies indicate that some of these beneficial effects may be partially mediated by S-methyl cysteine sulfoxide (SMCSO), a sulfur-rich, non-protein, amino acid found almost exclusively within cruciferous and alliums. This scoping review explores evidence for SMCSO, its potential roles in human health and possible mechanistic action. After systematically searching several databases (EMBASE, MEDLINE, SCOPUS, CINAHL Plus Full Text, Agricultural Science), we identified 21 original research articles meeting our inclusion criteria. These …

The Organization Of Serotonergic Fibers In The Pacific Angelshark Brain: Neuroanatomical And Supercomputing Analyses, Skirmantas Janušonis, Ralf Metzler, Thomas Vojta

Physics Faculty Research & Creative Works

Serotonergic axons (fibers) are a universal feature of all vertebrate brains. They form meshworks, typically quantified with regional density measurements, and appear to support neuroplasticity. The self-organization of this system remains poorly understood, partly because of the strong stochasticity of individual fiber trajectories. In an extension to our previous analyses of the mouse brain, serotonergic fibers were investigated in the brain of the Pacific angel shark (Squatina californica), a representative of a unique (ray-like) lineage of the squalomorph sharks. First, the fundamental cytoarchitecture of the angel shark brain was examined, including the expression of ionized calcium-binding adapter molecule 1 (Iba1, …

Synthesis And Characterization Of Free Radical Scavenging Dendrimer Nanogels Via Cross-Linking Reaction-Enabled Flash Nanoprecipitation, Lin Qi, Da Huang, Huari Kou, Anna Chernatynskaya, Nuran Ercal, Hu Yang

Chemistry Faculty Research & Creative Works

This work reports the development and evaluation of dendrimer-based nanogels based on Poly amidoamine (PAMAM) dendrimer generation 5, engineered to act as a carrier with reactive oxygen species (ROS)-scavenging capabilities. We developed a cross-linking reaction-enabled flash nanoprecipitation method in which the cross-linking reaction occurs during the flash nanoprecipitation process to form a cross-linked nanostructure. Using this approach, an N-hydroxy succinimide (NHS)-functionalized ROS-responsive thioketal cross-linker (TK-NHS) was synthesized and utilized to cross-link DAB-core PAMAM dendrimer G5, resulting in the formation of G5-TK nanogels. The resulting nanogels were characterized using dynamic light scattering and transmission electron microscopy, and their cytocompatibility, irritancy, cellular …

Scalable Fabrication Of High-Payload Dendrimer-Based Nanoparticles For Targeted Atherosclerosis Therapy, Huari Kou, Lin Qi, Da Huang, Jiandong Wu, Honglan Shi, Hu Yang

Chemistry Faculty Research & Creative Works

Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked Poly amidoamine (PAMAM) dendrimer nanoparticles. Notably, this approach allows simultaneous nanoparticle cross-linking and drug loading in a single step. The mannose moiety enabled specific targeting of macrophages via mannose receptors, enhancing the localization of …