Digital Commons Network^™

Immersive Mixed-Reality Anatomy Lab, Cassidy Norkett

Honors Theses

The Mixed Reality Heart Anatomy Lesson was created to address the WMU Homer Stryker M.D. School of Medicine’s need for an interactive and dynamic laboratory lesson. The application allows for a more efficient way for medical students to learn and comprehend the material. The design and development of a mixed reality application running on smart glasses provides students with a situation aware, fully engaged, and immersive learning experience. The Apple Vision Pro device allows medical students to complete their labs by merging physiology and anatomy concepts through 3D models, object detection, self-assessments, and an artificial intelligence chatbot. There can be …

Brain-Targeted Reactive Oxygen Species In Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, And Novel Therapeutic Pathways, Renjun Wang, Min Wang, Dongshu Du, Zhiying Shan, Lanrong Bi, Qing-Hui Chen

Michigan Tech Publications

Hypertension (HTN) is a complex disease with significant global health implications, driven by neural and oxidative mechanisms. Reactive oxygen species (ROS), once considered mere metabolic byproducts, are now recognized as one of the key contributors to dysfunction of the autonomic nerve system, which involves the onset and progression of HTN. This review highlights the dynamic roles of ROS in neuronal signaling, subcellular compartmentalization, and brain-immune interactions, focusing on their impacts on synaptic remodeling, neuroinflammation, and epigenetic modifications within key autonomic regions such as the paraventricular nucleus and rostral ventrolateral medulla. We discuss novel ROS sources, including microglia-derived and endoplasmic reticulum …

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

Per- And Polyfluoroalkyl Substance (Pfas) Degradation In Water And Soil Using Cold Atmospheric Plasma (Cap): A Review, Victor Somtochukwu Mbanugo, Boluwatife Stephen Ojo, Ta Chun Lin, Yue-Wern Huang, Marek Locmelis, Daoru Han

Biological Sciences Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFASs) are persistent organic chemicals found in numerous industrial applications and everyday products. The excessive amounts of PFASs in water and soil, together with their link to severe health issues, have prompted substantial public concerns, making their removal from the environment a necessity. Existing degradation techniques are frequently lacking due to their low efficiency, cost-effectiveness, and potential for secondary contamination. Cold Atmospheric Plasma (CAP) technology has emerged as a promising alternative, utilizing energized reactive species to break down PFASs under ambient conditions. Therefore, this review examines the efficacy and effectiveness of CAP in degrading PFASs by …

Stratigraphic Characteristics And Shale Gas Enrichment Interval Distribution Of The Lower Cambrian Qiongzhusi Formation, Upper Yangtze Region, China, Wang Hongyan, Shi Zhensheng, Zhao Qun, Zhou Tianqi, Wang Pengfei

Coal Geology & Exploration

Objective Shales in the Lower Cambrian Qiongzhusi Formation within the Upper Yangtze region preserve critical information about primitive oceans. Furthermore, these shales serve as vital source rocks and reservoirs, having demonstrated considerable potential for shale gas exploration. Methods Using seismic, borehole, and outcrop data, this study investigated the shale strata and their distribution in the Qiongzhusi Formation through comparative analysis. Accordingly, the sweet-spot interval was determined. Results and conclusions The results indicate that the Lower Cambrian Qiongzhusi Formation in the Upper Yangtze region can be divided into the first and second members (also referred to as the Qiong 1 and …

Alterity And Kinship: Co-Writing Posthumanist Speculative Nonfiction With Ai, Jeffrey Bardzell, Maliheh Ghajargar

Engineering Faculty Articles and Research

As a response to the climate crisis, scholarly literature has introduced new theoretical perspectives, such as posthumanism, which seek to reimagine the relationships between humans and nonhuman others, including environments, animals, and plants. Reimagining these relationships depends in large part on our ability to engage nonhumans in their otherness, or alterity, but doing so is challenging. Responding to calls throughout posthuman literature for experimental new modes of imaginative encounter with nonhumans, and inspired by speculative traditions from literature to design, we devise a methodology involving “creative experiments” aimed at disrupting, decentering, and disorienting the human-centered thinking that interferes with humans’ …

Critical Appraisal Of Multidrug Therapy In The Ambulatory Management Of Patients With Covid-19 And Hypoxemia. Part Ii: Causal Inference Using The Bradford Hill Criteria, Eleftherios Gkioulekas, Peter A. Mccullough, Colleen Aldous

School of Mathematical & Statistical Sciences Faculty Publications

We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and parallel evidence. The efficacy of the two most aggressive ivermectin-based multidrug protocols is supported by the Bradford Hill …

Synthetic Protein Mimetic Based Therapies For Neurodegeneration, Nicholas H. Stillman

Electronic Theses and Dissertations

Protein-protein interactions (PPIs) are crucial for the regulation of a majority of, if not every fundamental cellular process. Despite their role in regular biological processes, dysregulated and/or aberrant protein-protein interactions (aPPIs) are often related to the onset of disease including cancer, viral infection, and amyloid diseases. aPPIs have historically been deemed ‘undruggable’ due to their large surface area and lack of a binding cavity; however, today, more than 40 disease-related aPPIs have been targeted with small molecules and several of those have reached clinical trials.

A class of synthetic protein mimetics called oligopyridylamides (OPs) has been shown to inhibit disease-related …

An Alternative To Biliverdin, Mesobiliverdin Ixα And Mesobiliverdin-Enriched Microalgae: A Review On The Production And Applications Of Mesobiliverdin-Related Products, Naveena Poudyal, Jon Y. Takemoto, Yuan-Yu Lin, Cheng-Wei T. Chang

Chemistry and Biochemistry Student Research

Despite attracting interest for decades due to its anti-inflammatory and antioxidant capabilities, the use of biliverdin IXα (BV) in medicine and agriculture is hampered by uncertain purity and limited availability. A significant amount of effort has been devoted to the production and application of BV, but with limited success. Mesobiliverdin IXα (MBV), a natural BV analog derived from microalgae, offers a path to overcome the limitations of BV. MBV production is scalable, and it can be obtained at high purity. MBV and BV share important structural features (e.g., bridging propionate groups) and both are substrates of biliverdin reductase A (BVRA), …

Abiotic Variables Drive Different Aspects Of Fish Community Trait Variation And Species Richness Across The Continental United States, Alicia Mcgrew, Crysta Gantz, Brigid Wills, Benjamin Baiser, Sydne Record, Phoebe L. Zarnetske, Angela L. Strecker

Environmental Science and Management Faculty Publications and Presentations

Intraspecific trait variation (ITV) is an increasingly important aspect of biodiversity and can provide a more complete perspective on how abiotic and biotic processes affect individuals, species' niches and ultimately community-level structure than traditional uses of trait means. Body size serves as a proxy for a suite of traits that govern species' niches. Distributions of co-occurring species body sizes can inform niche overlap, relate to species richness and uncover mechanistic drivers of diversity. We leveraged individual-level body size (length) in freshwater fishes and environmental data from the National Ecological Observatory Network (NEON) for 17 lakes and streams in the contiguous …

Designing A Cave Air Monitoring System: Guide And Feedback From 15 Years Of Monitoring The Cussac Cave (France), Nicolas Peyraube, Jessica D. Villanueva, Fabien Naessens, Roland Lastennet, Sylvain Mateo, Alain Denis

International Journal of Speleology

Understanding the cave’s ventilation system is important for determining how the cavity interacts with external airflow. This requires a well-designed monitoring system. This article addresses these key aspects: how to build a monitoring system for cave air parameters and how to assess the ventilation of a cave. We proposed a flowchart to help address the issues in: 1) the modularity of a monitoring system, 2) the use of “homemade device” or “ready to use device”, 3) the frequency of measure and its effect on the electrical consumption, 4) the duration of the survey, and 5) the accessibility of the recorded …

Development Of S(Vi) And S(Iv) Chemistry: From Asymmetric Synthesis To Covalent Reactive Groups, Chuan Shan

USF Tampa Graduate Theses and Dissertations

This dissertation mainly covers the development of synthetic methodologies related to several heteroatom functional groups, including phosphonates P(V), sulfoximines S(VI), sulfonimidamides S(VI), sulfonimidoyl fluorides S(VI), and sulfinamides S(IV). The interests in these functionalities are not only out of chemistry curiosity but also due to their pharmaceutical importance indicated by the existing drug molecules that contain these functional groups. The first chapter introduced the importance of phosphonates in biochemistry and organic synthesis, also provided some essential background of our synthetic efforts. The second chapter described the phosphonate synthesis from commercially available starting materials, with the purpose to obtain heterocyclic phosphonates in …

The Few-Nexus: Using Soil To Grow Meaning And Relevance In Undergraduate General Education Earth Science Courses, Katherine Mccarville

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Soils are central to human survival, through their critical roles in regulating water supplies and providing the medium for most agricultural productivity. Even as fewer and fewer students know where their water and food come from, and where their wastes go, soils tend to be under-emphasized in Earth science general education courses. Combining a place-based focus on soils with the FEW-Nexus model provides an integrating context for concepts and information that students sometimes perceive as disconnected and irrelevant to them. This approach can transform the experiences and learning of undergraduate students in the Earth science general education curriculum.

“Smart Trap”: A Portable Device For Real-Time Mosquito Capturing And Classification Using Image-Based Analysis, Fahim Rahman

USF Tampa Graduate Theses and Dissertations

Capturing mosquitoes in real-time and taking high-quality images for classification with state-of-the-art methods is not only time-consuming but also expensive. Sometimes even carefully controlled environments and experimental setups fail to capture living mosquitoes. Catching live mosquitoes is necessary to be able to study aspects of their physiology and behavior that cannot be investigated by collections of resting mosquitoes and dead specimens, and to help estimate the local population numbers. My thesis introduces a “Smart Trap”, a small portable device that can attract mosquitoes in real-time, capture them, take high-quality images with dual cameras, and store those images in the cloud. …

The Sustainability Stones: Culturally Embedded Conservation Strategies And Their Vulnerability In Maupiti, French Polynesia, Russell Fielding, Fiona Gimenez

Honors College Faculty Publications

This paper explores culturally embedded conservation strategies through the lens of the traditional agroforestry and fisheries cycles in Maupiti, French Polynesia. By pairing certain breadfruit cultivars with specific fish species, the island’s community created a culinary system that regulates the seasonal consumption of marine resources, making the sustainable use of those resources more likely. While modern pressures such as reduced breadfruit diversity, competition with imported foods, and climate change have weakened these traditional practices, they remain an example of local ecological knowledge guiding conservation. The study highlights the threat of losing sustainable resource-use practices and biodiversity as both biodiversity and …

Refugium Amidst Ruins: Unearthing The Lost Flora That Escaped The End-Permian Mass Extinction, Huiping Peng, Wan Yang, Mingli Wan, Jun Liu, Feng Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Searching for land refugia becomes imperative for human survival during the hypothetical sixth mass extinction. Studying past comparable crises can offer insights, but there is no fossil evidence of diverse megafloral ecosystems surviving the largest Phanerozoic biodiversity crisis. Here, we investigated palynomorphs, plant, and tetrapod fossils from the Permian-Triassic South Taodonggou Section in Xinjiang, China. Our fossil records, calibrated by a high-resolution age model, reveal the presence of vibrant regional gymnospermous forests and fern fields, while marine organisms experienced mass extinction. This refugial vegetation was crucial for nourishing the substantial influx of surviving animals, thereby establishing a diverse terrestrial ecosystem …

Salmon As An Ecological Pathway Of Contaminants Into Alaskan Food Webs, Miranda Brohman, Gretchen Roffler, Dimitri G. Giarikos, David Kerstetter, Amy C. Hirons

SECLER Data

Salmon are important fish taxa for humans and animals in hemiboreal and subarctic ecosystems. Trace elements and their marine food web bioaccumulation raises biomagnification and potential human health risk concerns. Sixteen trace element concentrations and their health risk assessments were determined in seven different tissues of two Southeast Alaska salmon species (chum, Oncorhynchus keta and pink, Oncorhynchus gorbuscha). Chum tissues had overall higher trace element concentrations compared to pink, which may be attributed to a difference of diets, generally longer-lived and spending more time in the open ocean. All kidney and liver samples exceeded the tolerable daily intake for …

Characterizing Rainfall Variability Within A Series Of Storms Over Northern California In February 2017, Parker Jan Malek

Dissertations and Theses

In February 2017, a series of storms with associated atmospheric rivers (ARs) made landfall in the US state of California, dropping large amounts of precipitation over the Sierra Nevada Mountains and their western foothills. The rainfall from these ARs, long, narrow bands of water vapor that transport large amounts of water vapor from the tropics to the mid-latitudes, instigated the near-failure of the Oroville Dam located at the southeastern edge of the Feather watershed outside the city of Oroville in the state's Central Valley. This case study provides a synoptic and mesoscale diagnosis of the drivers of rainfall pulses that …

Closing Ceremony Speech, S. Ray Smith

IGC Proceedings (1977-2023)

No abstract provided.

Strategies Of Fertilizer Nitrogen Applications To Grassland For Beef: Effects On Production And Soil Mineral Nitrogen, N M. Titchen, R J. Wilkins, L Philipps, D Scholefield

IGC Proceedings (1977-2023)

Experiments in Britain have shown beef production increases with fertilizer-N application to grazed grassland up to at least 300 kg N/ha (Wilkins et al., 1987; Baker and Mayne, 1988). However in view of the small offtake of N in the animal products (c.30 kg/ha) there is increased concern on the fate of the applied N, particularly in relation to loss of nitrate by leaching (Garwood and Ryden, 1986). This paper reports a 3-year experiment which examined the impact on production and on N movements of different strategies of fertilizer-N appli­cation and of the effects of removing grazing livestock at the …

F.A.O Design K*B*P Trials In The Mid-Altitude Zone Of Yunnan Province, Southern China, J Bruce-Smith, Yang Guo-Rong, Huang Bi-Zhi, Li Ji-Xin

IGC Proceedings (1977-2023)

The Project is investigating the development of « improved pastures » as a practical way to increase ruminant livestock production. Some preliminary results of fertilizer requirements, indicated that K and B may be required as well as P (Wang el al., 1985) for the establishment of such pastures in this mid-alti­tude (2,000 m) transitional sub-tropic-temperate zone of Yunnan. The objective of this paper is to present some experiences from applying the Hauser (1971) truncated fac­torial design trials (widely used by FAO to obtain N, P, K, fert­ilizer recommendations for cereal crops) to a pasture establish­ment situation where P. K and …

Effect Of Nitrogen Fertilization In Combination With Potassium And Phosphorus And Cutting Frequency On The Yield Of Brachiaria Ruzizensis In Adamawa, Cameroon, E T. Pamo, D Pieper

IGC Proceedings (1977-2023)

Fertilizers have been shown to increase forage yields under some conditions (Owensby and Smith, 1975), but has very little effect under other conditions (Stoddart et al., 1975). Thus in recent years a great deal of attention has been focussed on the ways and possibilities of increasing forage production by fertil­ization. Various experiments have been conducted on the response of Brarhiaria ruziziensis Germain and Evrad, one of the best perennial forage grasses of the region, to fertilization at Wakwa Animal Research Station. Yonkeu et al., (1986) indicated that application of phosphorus did not lead to improved yield of the forage on …

The Influence Of Cow Manure On Forage Yields Of King Grass In A Ferrasol In Cuba, G Crespo, M Oduardo

IGC Proceedings (1977-2023)

Experiments conducted in sandy and brown soils in Cuba demonstrated the beneficial effect of manure for accelerating the establishment of forage plants, and the possibility of dimi­nishing up to 50 % the dosage of N fertilizer requirements to obtain maximum forage yield (Crespo and Diez 1978; Crespo and Arteaga 1984). The aims of the present experiments were: a) to determine the best time of application of cow manure and b) to learn the influence of manure and nitrogenous fertilizer on forage yield of king grass in a ferrasol soil.

A Comparison Of Unconventional Microwave And Ultrasound-Assisted Extraction Methods Used For Flavonoids, Istiqomah Rahmawati, Daffa Hafiziaulhaq Azizi, Jihan Nafila Wibowo, Muhammad Reza, Boy Arief Fachri, Bekti Palupi, Meta Fitri Rizkiana, Helda Wika Amini, Ifan Ramadana, Felix Arie Setiawan

Makara Journal of Science

Cocoa pods (Theobroma cacao L.) are a rich source of flavonoids, which are natural antioxidants known for their health benefits. This study investigated the use of microwave-assisted extraction (MAE) and ultrasound-assisted ex-traction (UAE) to extract the maximum flavonoids and antioxidants from cocoa pods. MAE and UAE are efficient and sustainable methods for extracting bioactive compounds like flavonoids and antioxidants from cocoa pods, offer-ing faster extraction, reduced solvent use, and better compound preservation compared to conventional methods. These technologies unlock the untapped potential of cocoa pods for applications in food, cosmetics, and pharmaceuti-cals. The effects of extraction time (2–10 min), microwave …

Comprehensive Review On The Application Of Bio-Immunoinformatics In The Development Of Highly Ef-Fective New Candidate Vaccines Against Tuberculosis, Ahyar Ahmad, Andriansjah Rukmana, Miski A. Khairinisa, Dian A. E. Pitaloka, Rosana Agus, Rusdina B. Ladju, Tarwadi Ahmad, Astutiati Nurhasanah, Carina C. D. Joe, Muhammad N. Massi, Harningsih Karim, Irda Handayani, Siti Roszilawati Binti Ramli

Karbala International Journal of Modern Science

Tuberculosis (TB) remains a significant public health challenge worldwide. Currently, Bacillus Calmette-Guerin (BCG) is the only vaccine available for TB prophylaxis. However, the efficacy of the BCG vaccine against adult pulmonary TB is considered inconsistent. This condition encourages researchers to look for more effective options, such as subunit vaccines. This condition requires the development of a more effective subunit vaccine to protect active TB in productive and adult ages. There is an urgent need for more effective vaccines, as the Bacillus Calmette-Guérin (BCG) vaccine currently available has inconsistent efficacy and is only partially effective in adults. Bio-immunoinformatics, an interdisciplinary field …

Articulated Robot Path Planning Based On Hybridization Of Adaptive ‎Dimensionality Algorithm And Grey Wolf Optimizer In Dynamic Environments, Noor Kadhim Ayoob‏, Ali Hadi Hasan

Karbala International Journal of Modern Science

A new method was developed to plan a path for a robotic articulated vehicle using the Grey Wolf Optimizer (GWO) ‎and Adaptive ‎Dimensionality (AD)‎. Existing studies in robotics path planning ignore the differences between robots in terms of size and flexibility and allocate a single cell to the robot regardless of the mentioned factors. Since the articulated robotic vehicle is longer than obstacles moving in the environment, this study takes into account vehicle size and flexibility in path planning by adapting the number of cells allocated to the robotic vehicle to contain the vehicle parts while performing different movements. Considering …

Transcriptional Profiles Reveal Physiological Mechanisms For Compensation During A Simulated Marine Heatwave In Yellowtail Kingfish (Seriola Lalandi), Sharon E. Hook, Ryan J. Farr, Jenny Su, Alistair J. Hobday, Catherine Wingate, Lindsey Woolley, Luke Pilmer

Fisheries Research Articles

Background

Changing ocean temperatures are already causing declines in populations of marine organisms. Predicting the capacity of organisms to adjust to the pressures posed by climate change is a topic of much current research effort, particularly for species we farm or harvest. To explore one measure of phenotypic plasticity, the physiological compensations in response to heat stress as might be experienced in a marine heatwave, we exposed Yellowtail Kingfish (Seriola lalandi) to sublethal heat stress, and used the transcriptome in gill and muscle, benchmarked against heat shock proteins and oxidative stress indicators, to characterise the acute heat stress …

Predicting Precipitation And Ndvi Utilization Of The Multi-Level Linear Mixed-Effects Model And The Ca-Markov Simulation Model, Fatima Belhaj, Hlila Rachid, Ouallali Abdessalam, Aqil Tariq, Belkendil Abdeldjalil, Beroho Mohamed, Hassan Alzahrani, Hajra Mustafa, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

The current work intends to reconstruct the spatiotemporal evolution of precipitation and the Normalized Differentiate Vegetation Index (NDVI) in the Loukkos watershed and provide scenarios for their recent and future evolution, therefore determining the degree of association. We conducted a study on the time series data of precipitation and NDVI from 1999 to 2019. The NDVI prediction is conducted using the CA-Markov model and the linear mixed-effects multi-level model (LME) with precipitation data from 2019 to 2040. The CA-Markov model was employed to predict the vegetation indices for 2029 and 2040 using 1999, 2009, and 2019 data. The model simulates …

Designing Accessible Ui/Ux For Epileptic Patients: A Scalable Solution For Music Therapy Delivery, Amethyst G.H. Mckenzie

Computer Science Senior Theses

How can we design an accessible, scalable UI/UX system tailored to the cognitive, visual, and motor impairments of epileptic patients, that ensures safe and effective interactions with music therapy applications? This research explores the intersection of accessibility, user-centred design, and digital health, using an iterative design process to develop and refine the SONATA app—a clinically deployable music therapy platform.

Through two prototype iterations, usability testing, and quantitative event logging, this study compares the effectiveness of structured versus flexible navigation in improving user experience. Key findings reveal that structured navigation reduces unintended detours, while progressive disclosure techniques enhance instructional clarity. Additionally, …

Effects Of Phosphogypsum, Phsophorus And Lime On Andropogon Gayanus Kunth, V T. Paulino, E Malavolta

IGC Proceedings (1977-2023)

There are several factors which determine the low animal productivity in the tropics. Among these factors, inadequate nutrition is the most limiting one followed by the low natural fertility and high acidity of the soils in these regions. Previous findings have shown important soil nutrient deficiencies in some Brazilian cerrado soils. Malavolta (1952) demonstrated sulfur (S) deficiencies, while Werner et al. (1967) found plant response to S. Responses to phosphorus addition are very common in this kind of soil and in tropical America there are rates of phosphorus being applied, which sometimes are uneconomical for the formation and maintenance of …