Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Stable isotopes (4)
- Pleistocene (3)
- Alberta (2)
- Carbonate (2)
- Corrosion (2)
-
- Drug delivery (2)
- GPU (2)
- Mammoth (2)
- Mastodon (2)
- Microstructure (2)
- Paleoclimate (2)
- Paleoecology (2)
- Phosphane-ene (2)
- Phosphine (2)
- Phosphorus (2)
- 5-fluorouracil anti-cancer drug (1)
- Aluminium corrosion (1)
- Amphiphilic block copolymers (1)
- Ancient Egypt (1)
- Antibacterial (1)
- Architecture (1)
- Arizona (1)
- Atmospheric deposition (1)
- Attenuation correction (1)
- BSA (1)
- Band gap (1)
- Belief (1)
- Biodegradable polymers (1)
- Biomineralization in vitro (1)
- Biopolymers (1)
- Publication Year
- Publication
- Publication Type
Articles 1 - 30 of 35
Full-Text Articles in Entire DC Network
Effect Of Passivation And Surface Treatment Of A Laser Powder Bed Fusion Biomedical Titanium Alloy On Corrosion Resistance And Protein Adsorption, Saman Nikpour, Jeffrey Henderson, Sina Matin, Heng-Yong Nie, Jonas Hedberg, Vahid Dehnavi, Yara Hosein, David Holdsworth, Mark Biesinger, Yolanda Hedberg
Effect Of Passivation And Surface Treatment Of A Laser Powder Bed Fusion Biomedical Titanium Alloy On Corrosion Resistance And Protein Adsorption, Saman Nikpour, Jeffrey Henderson, Sina Matin, Heng-Yong Nie, Jonas Hedberg, Vahid Dehnavi, Yara Hosein, David Holdsworth, Mark Biesinger, Yolanda Hedberg
Chemistry Publications
The biomedical titanium alloy Ti6Al4V has excellent corrosion resistance and biocompatibility and is, therefore, widely used in orthopedic and orthodontic implants. Biomedical implants are increasingly fabricated by additive manufacturing, such as laser powder bed fusion (LPBF). These manufacturing protocols often include sandblasting, surface finish, and passivation. This study aims to investigate the effect of different surface finishes and the commonly used ASTM F86-13 nitric acid passivation for LPBF Ti6Al4V on its corrosion resistance, metal release, and surface changes in benign (bovine serum albumin in a pH 7.4 buffer) and harsh (hydrochloric acid at pH 1.5) solutions using various electrochemical and …
A Bio-Tribocorrosion Comparison Between Additively Manufactured And Forged Ti6al4v Parts, Sina Matin, Sahar Toorandaz, Saman Nikpour, Hamidreza Abdolvand, Eshan Toyserkani, Yolanda S. Hedberg
A Bio-Tribocorrosion Comparison Between Additively Manufactured And Forged Ti6al4v Parts, Sina Matin, Sahar Toorandaz, Saman Nikpour, Hamidreza Abdolvand, Eshan Toyserkani, Yolanda S. Hedberg
Chemistry Publications
Ti6Al4V has been used widely as a biomedical alloy and is increasingly manufactured by additive manufacturing due to customized shapes. As implant material, it is frequently exposed to both friction and corrosive environments. This study investigates the effect of the fabrication process (laser powder bed fusion and forging) on the tribocorrosion behavior of Ti6Al4V in various environments including diluted hydrochloric acid to simulate the acidic environment in a crevice (HCl), phosphate-buffered saline (pH 7.3) with 10 g/L bovine serum albumin (PBS+BSA), and PBS+BSA with 30 mM H2O2. While the presence of BSA hindered the repassivation (reforming of the protective passive …
Corrosion Of Implant Materials In The Human Body, Maedeh Barzmehri
Corrosion Of Implant Materials In The Human Body, Maedeh Barzmehri
Corrosion Research
This paper extensively examines the complex problem of implant corrosion occurring within the human body. The corrosion of implants gives rise to substantial challenges, encompassing compromised implant durability, patient safety concerns, and potential adverse impacts on the long-term functionality of the medical device. The study's primary objectives include offering a concise overview of the various corrosion mechanisms that impact a range of implant materials and outlining health complications linked to the byproducts of implant corrosion. Furthermore, it delves into a cost analysis specific to hip or knee revision arthroplasty, which has become a prevalent scenario in implant failure cases on …
In Vitro Corrosion And Biocompatibility Behavior Of Cocrmo Alloy Manufactured By Laser Powder Bed Fusion Parallel And Perpendicular To The Build Direction, Masoud Atapour, Saber Sanaei, Zheng Wei, Mohammadali Sheikholeslam, Jeffrey D. Henderson, Ubong Eduok, Yara K. Hosein, David W. Holdsworth, Yolanda S. Hedberg, Hamid Reza Ghorbani
In Vitro Corrosion And Biocompatibility Behavior Of Cocrmo Alloy Manufactured By Laser Powder Bed Fusion Parallel And Perpendicular To The Build Direction, Masoud Atapour, Saber Sanaei, Zheng Wei, Mohammadali Sheikholeslam, Jeffrey D. Henderson, Ubong Eduok, Yara K. Hosein, David W. Holdsworth, Yolanda S. Hedberg, Hamid Reza Ghorbani
Chemistry Publications
Biomedical cobalt-chromium-molybdenum alloys (CoCrMo) are frequently used for orthopedic implant and dental materials exposed to mechanical stressors, such as wear and cyclic load. Due to the high demand for customizable implant shapes, these alloys are increasingly manufactured by additive manufacturing methods such as laser powder bed fusion (LPBF). LPBF results in different microstructures and surface roughness as a function of the building direction. This study investigated the corrosion resistance, bioactivity, biocompatibility, and microstructure of LPBF CoCrMo (low carbon content, heat-treated) in the XY (perpendicular) and XZ (parallel) plane of the building direction for as-printed (as-received) and abraded surfaces. A distinct …
A Molecular Dynamics Study Of Polymer Chains In Shear Flows And Nanocomposites, Venkat Bala
A Molecular Dynamics Study Of Polymer Chains In Shear Flows And Nanocomposites, Venkat Bala
Electronic Thesis and Dissertation Repository
In this work we study single chain polymers in shear flows and nanocomposite polymer melts extensively through the use of large scale molecular dynamics simulations through LAMMPS. In the single polymer chain shear flow study, we use the Lattice Boltzmann method to simulate fluid dynamics and also include thermal noise as per the \emph{fluctuation-dissipation} theorem in the system. When simulating the nanocomposite polymer melts, we simply use a Langevin thermostat to mimic a heat bath. In the single polymer in shear flow study we investigated the margination of a single chain towards solid surfaces and how strongly the shear flow …
Intra-Population Variation Of Hair And Fingernail Stable Hydrogen, Oxygen, Carbon And Nitrogen Isotopes In London, Ontario, Canada Residents During The Covid-19 Pandemic, Sawyer C E Rowe
Electronic Thesis and Dissertation Repository
Lockdowns and travel restrictions during the COVID-19 pandemic forced a significant fraction of London, Ontario, Canada residents to remain in one location for long enough to reach isotopic equilibrium with their primary drinking water source(s). This situation created ideal natural conditions for measuring the isotopic fractionation between the stable hydrogen and oxygen isotopes of drinking water and hair or nail tissues, and for determining the magnitude of intra-population variation in tissue δ2H and δ18O. Hair and nail of participants who reported exclusively drinking London municipal tap water spanned much larger δ2H and δ18 …
Metal Release From A Biomedical Cocrmo Alloy In Mixed Protein Solutions Under Static And Sliding Conditions: Effects Of Protein Aggregation And Metal Precipitation, Zheng Wei, Valentine Romanovski, Luimar Filho, Cecilia Persson, Yolanda S. Hedberg
Metal Release From A Biomedical Cocrmo Alloy In Mixed Protein Solutions Under Static And Sliding Conditions: Effects Of Protein Aggregation And Metal Precipitation, Zheng Wei, Valentine Romanovski, Luimar Filho, Cecilia Persson, Yolanda S. Hedberg
Chemistry Publications
Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses and dental implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical and chemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from, and the surface composition of, a CoCrMo alloy was investigated in physiological relevant solutions (phosphate buffered saline, PBS, with varying concentrations of fibrinogen from bovine plasma and/or bovine serum albumin) at pH 7.3 …
Patch Testing With Aluminium Finn Chambers Could Give False-Positive Reactions In Patients With Contact Allergy To Aluminium, Lisbeth Rosholm Comstedt, Jakob Dahlin, Magnus Bruze, Yolanda S. Hedberg, Mihály Matura, Cecilia Svedman
Patch Testing With Aluminium Finn Chambers Could Give False-Positive Reactions In Patients With Contact Allergy To Aluminium, Lisbeth Rosholm Comstedt, Jakob Dahlin, Magnus Bruze, Yolanda S. Hedberg, Mihály Matura, Cecilia Svedman
Chemistry Publications
Background
Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).
Objectives
To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.
Method
A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.
Results
A total of 5446 patients had been tested …
Ph-Sensitive Chitosan Nanoparticles For Salivary Protein Delivery, Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira
Ph-Sensitive Chitosan Nanoparticles For Salivary Protein Delivery, Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira
Chemistry Publications
Salivary proteins such as histatins (HTNs) have demonstrated critical biological functions directly related to tooth homeostasis and prevention of dental caries. However, HTNs are susceptible to the high proteolytic activities in the oral environment. Therefore, pH-sensitive chitosan nanoparti-cles (CNs) have been proposed as potential carriers to protect proteins from enzymatic degradation at physiological salivary pH. Four different types of chitosan polymers were investigated and the optimal formulation had good batch to batch reproducibility, with an average hydrodynamic diame-ter of 144 ± 6 nm, a polydispersity index of 0.15 ± 0.04, and a zeta potential of 18 ± 4 mV at …
Gibbs Point Process Model For Young Star Clusters In M33, Dayi Li, Pauline Barmby
Gibbs Point Process Model For Young Star Clusters In M33, Dayi Li, Pauline Barmby
Physics and Astronomy Publications
We demonstrate the power of Gibbs point process models from the spatial statistics literature when applied to studies of resolved galaxies. We conduct a rigorous analysis of the spatial distributions of objects in the star formation complexes of M33, including giant molecular clouds (GMCs) and young stellar cluster candidates (YSCCs). We choose a hierarchical model structure from GMCs to YSCCs based on the natural formation hierarchy between them. This approach circumvents the limitations of the empirical two-point correlation function analysis by naturally accounting for the inhomogeneity present in the distribution of YSCCs. We also investigate the effects of GMCs' properties …
Self-Immolative Polymers As A Degradable And Triggerable Class Of Surfactants, Siamak Keshtpour
Self-Immolative Polymers As A Degradable And Triggerable Class Of Surfactants, Siamak Keshtpour
Electronic Thesis and Dissertation Repository
Self-immolative polymers (SIPs) are degradable polymers that undergo end-to-end depolymerization upon triggering. They have potential for the development of degradable surfactants addressing human and environmental toxicity concerns associated with non-degradable surfactants, but they have not yet been investigated as surfactants. Herein, polyglyoxylamide SIPs with different pendent groups and end-caps were synthesized, envisioning they could serve as depolymerizable analogues of poly(vinyl alcohol) and its derivatives. Polyglyoxylamides with pendent hydroxyls stabilized both PEA and PLA particle suspensions. They showed the potential to undergo triggered degradation, resulting in destabilization of the suspensions. However, untriggered suspensions exhibited poor long-term stability, so further structural tuning …
Methodologies For Metal Functionalization Of Phosphorus Based Photopolymer Networks, Vanessa Béland
Methodologies For Metal Functionalization Of Phosphorus Based Photopolymer Networks, Vanessa Béland
Electronic Thesis and Dissertation Repository
Photopolymer networks with phosphonium cation, alkyl phosphine and olefin functionality were designed, synthesized and functionalized with metals by metathesis, coordination and hydrometallation reactions, respectively. The materials were strategically designed so that the metal functionalization step could be monitored and quantified. In some cases, this involved characterization by IR, NMR, or X-ray spectroscopic techniques, or by comparison to molecular analogues. It was found that by using a bi-functional photopolymer network, the material could be bi-metallized by orthogonal mechanisms. All metallized polymer networks were tested for their suitability as precursors to metal-containing ceramics. The polymers were pyrolyzed, and on analysis it was …
Using Stable Isotopes To Understand Survival Versus Extinction Of Late Pleistocene Muskoxen, Stephanie Mabee
Using Stable Isotopes To Understand Survival Versus Extinction Of Late Pleistocene Muskoxen, Stephanie Mabee
Electronic Thesis and Dissertation Repository
This thesis uses stable isotopes to investigate the adaptive advantages of Ovibos moschatus, a muskox, relative to now-extinct Pleistocene megafauna in eastern Beringia (Yukon Territory and Alaska), including another muskox Bootherium bombifrons. Ecological niches were defined for Ovibos and Bootherium using stable carbon and nitrogen isotope compositions of bone collagen. Plant remains trapped in modern Ovibos molars were used to determine the carbon and nitrogen isotope collagen-diet discrimination factors, which were then applied to ancient specimens. Ovibos possessed larger isotopic – and hence ecological – niches than Bootherium across eastern Beringian sites. The larger niche suggests that Ovibos …
Haptics-Enabled, Gpu Augmented Surgical Simulation Platform For Glenoid Reaming, Vlad Popa
Haptics-Enabled, Gpu Augmented Surgical Simulation Platform For Glenoid Reaming, Vlad Popa
Electronic Thesis and Dissertation Repository
Surgical simulators are technological platforms that provide virtual substitutes to the current cadaver-based medical training models. The advantages of exposure to these devices have been thoroughly studied, with enhanced surgical proficiency being one of the assets gained after extensive use. While simulators have already penetrated numerous medical domains, the field of orthopedics remains stagnant despite a demand for the ability to practice uncommon surgeries, such as total shoulder arthroplasty (TSA). Here we extrapolate the algorithms of an inhouse software engine revolving around glenoid reaming, a critical step of TSA. The project’s purpose is to provide efficient techniques for future simulators, …
The Development Of Platforms For Inhibiting Rhamm-Ha Interactions & The Development Of An Optical Probe For Measuring Glomerular Filtration Rate, Alexandra Hauser-Kawaguchi
The Development Of Platforms For Inhibiting Rhamm-Ha Interactions & The Development Of An Optical Probe For Measuring Glomerular Filtration Rate, Alexandra Hauser-Kawaguchi
Electronic Thesis and Dissertation Repository
Carbohydrates are a class of molecule occurring widely in the body. Their presence has varied biological implications, generating clinical interest regarding their impact on disease prognosis. This thesis will investigate the development of chemical entities surrounding two carbohydrates, hyaluronan and inulin.
The Receptor for hyaluronan mediated motility (RHAMM) is one of several receptors for hyaluronan (HA), a polysaccharide that, when fragmented, has pro-angiogenic and inflammatory properties. RHAMM expression is tightly regulated during homeostasis but increases in response to cellular stress, including during injury or disease states. HA-RHAMM interactions stimulate the Ras-ERK-Mek pathway to promote cell motility, differentiation, and proliferation. Specific …
The Incorporation Of Phosphorus Into Block Copolymers And Their Self-Assembly, Benjamin F. Hisey
The Incorporation Of Phosphorus Into Block Copolymers And Their Self-Assembly, Benjamin F. Hisey
Electronic Thesis and Dissertation Repository
The content of this thesis focuses on the incorporation of phosphorus into amphiphilic block copolymers (BCPs) for the realization of novel properties in the solution phase self-assembled materials derived from the BCPs. The incorporation was achieved through either attaching phosphorus to the terminus of already existing BCPs or the synthesis of novel BCPs from prepared or commercially available phosphorus containing monomers. The phosphorus containing polymers exhibited properties dependent on the existence of the phosphorus species in the BCPs. The first example of this is the modification of poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) copolymers by the attachment of tetraalkyl …
Tuning The Hydrophobic Cores Of Self-Immolative Polyglyoxylate Assemblies, Bo Fan, Rebecca E. Yardley, John F. Trant, Aneta Borecki, Elizabeth R. Gillies
Tuning The Hydrophobic Cores Of Self-Immolative Polyglyoxylate Assemblies, Bo Fan, Rebecca E. Yardley, John F. Trant, Aneta Borecki, Elizabeth R. Gillies
Chemistry Publications
Polyglyoxylates are a recently-introduced class of self-immolative polymers, that depolymerize to small molecules upon the cleavage of a stimuli-responsive end-cap from the polymer terminus. The incorporation of different pendant ester groups or other aldehyde monomers offers the potential to tune the polymer properties, but this remains largely unexplored. With the goal of tuning the self-assembly and drug-loading properties of polyglyoxylate block copolymers, we explored the polymerization and copolymerization of n-butyl glyoxylate, L-menthyl glyoxylate, and chloral with ethyl glyoxylate to form UV light-responsive polyglyoxylates. The resulting polymers were coupled to poly(ethylene glycol) to afford amphiphilic block copolymers. Self-assembly of the …
Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed
Fabrication And Modification Of Titania Nanotube Arrays For Harvesting Solar Energy And Drug Delivery Applications, Ahmed El Ruby Abdel Rahman Mohamed
Electronic Thesis and Dissertation Repository
The fast diminishing of fossil fuels in the near future, as well as the global warming caused by increasing greenhouse gases have motivated the urgent quest to develop advanced materials as cost-effective photoanodes for solar light harvesting and many other photocatalytic applications. Recently, titania nanotube arrays (TNTAs) fabricated by anodization process has attracted great interest due to their excellent properties such as: high surface area, vertically oriented, highly organized, one-dimensional, nanotubular structure, photoactivity, chemical stability and biocompatibility. This unique combination of excellent properties makes TNTAs an excellent photoanode for solar light harvesting. However, the relatively wide band gap energy of …
Developments In Pet-Mri For Radiotherapy Planning Applications, John Christian Patrick
Developments In Pet-Mri For Radiotherapy Planning Applications, John Christian Patrick
Electronic Thesis and Dissertation Repository
The hybridization of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides the benefit of soft-tissue contrast and specific molecular information in a simultaneous acquisition. The applications of PET-MRI in radiotherapy are only starting to be realised. However, quantitative accuracy of PET relies on accurate attenuation correction (AC) of, not only the patient anatomy but also MRI hardware and current methods, which are prone to artefacts caused by dense materials. Quantitative accuracy of PET also relies on full characterization of patient motion during the scan. The simultaneity of PET-MRI makes it especially suited for motion correction. However, quality assurance …
Analysis Of 3d Cone-Beam Ct Image Reconstruction Performance On A Fpga, Devin Held
Analysis Of 3d Cone-Beam Ct Image Reconstruction Performance On A Fpga, Devin Held
Electronic Thesis and Dissertation Repository
Efficient and accurate tomographic image reconstruction has been an intensive topic of research due to the increasing everyday usage in areas such as radiology, biology, and materials science. Computed tomography (CT) scans are used to analyze internal structures through capture of x-ray images. Cone-beam CT scans project a cone-shaped x-ray to capture 2D image data from a single focal point, rotating around the object. CT scans are prone to multiple artifacts, including motion blur, streaks, and pixel irregularities, therefore must be run through image reconstruction software to reduce visual artifacts. The most common algorithm used is the Feldkamp, Davis, and …
Creating Functional Materials With Phosphorus, Tyler John Cuthbert
Creating Functional Materials With Phosphorus, Tyler John Cuthbert
Electronic Thesis and Dissertation Repository
Understanding the relationship between small molecules or polymers and how they affect the properties of materials they compose is the basis of materials science. Using unique and versatile components can impart useful and interesting properties to materials. Here, we aimed to extend this understanding to phosphorus, and the known properties it possesses. This included the production of photopolymerizable coatings containing phosphonium molecules and polymers for antifouling and antibacterial applications. The synthesis and characterization of these phosphonium components was completed and materials were produced utilizing UV curing technology. Addition of these components produced coatings that could resist bacteria attachment and efficiently …
Static Magnetic Field Interactions Of Medical Devices In The Mri Environment, Spencer Baird Parent
Static Magnetic Field Interactions Of Medical Devices In The Mri Environment, Spencer Baird Parent
Electronic Thesis and Dissertation Repository
Background: The current procedures and guidelines for testing medical devices require that conservative testing be carried-out using the “worst-case” device or device configuration for each interaction (force, torque, heating, et cetera) of importance, and the results of those tests be used to inform regulatory labeling for that device. One of the most difficult elements of carrying out the above procedure is the determination of what represents a “worst-case” device or device configuration. A simulation “pipeline” would enable a systematic procedure for identification of the worst-case device or device configuration for magnetic force from an otherwise impossibly large set of options. …
Giant Beaver (Castoroides) Palaeoecology Inferred From Stable Isotopes, Tessa Plint
Giant Beaver (Castoroides) Palaeoecology Inferred From Stable Isotopes, Tessa Plint
Electronic Thesis and Dissertation Repository
Stable isotope analysis was used to explore unresolved questions about the palaeoecology of the extinct Pleistocene giant beaver (Castoroides). The δ13C, δ15N, and δ18O of bone collagen and structural carbonate from enamel served as proxies for palaeodiet and palaeoclimate. A new baseline for freshwater and terrestrial plant δ13C and δ15N was utilized in a mixing model (SIAR) to assess rodent feeding niche. SIAR analysis indicated that Castoroides’ consumed a diet of predominantly macrophytes, making them reliant on wetland habitat for food. Based on isotopic data for potential …
Limiting The Impact Of Destructive Analytical Techniques Through Sequential Microspatial Sampling Of The Enamel From Single Teeth, Alexis E. Dolphin, Mathew A. Teeter, Christine D. White, Fred J. Longstaffe
Limiting The Impact Of Destructive Analytical Techniques Through Sequential Microspatial Sampling Of The Enamel From Single Teeth, Alexis E. Dolphin, Mathew A. Teeter, Christine D. White, Fred J. Longstaffe
Earth Sciences Publications
A fundamental research concern within contemporary bioarchaeology is the sensitive balance between the preservation of human remains and the use of destructive techniques to collect information. Here we describe one example of how multiple microspatial destructive/semi-destructive techniques may be carried out in sequence using only the enamel of a single tooth. With careful planning of both sample preparation strategies and sequencing of sampling methods, it is possible to produce multiple datasets, and yet to retain material for future analyses.
In this case, enamel from the teeth of 27 individuals who lived during the early medieval period (AD 1170-1198) in Bergen, …
Taxonomy, Location Of Origin, And Health Status Of Proboscideans From Western Canada Investigated Using Stable Isotope Analysis, Jessica Z. Metcalfe, Fred Longstaffe, Christopher N. Jass, Grant D. Zazula, Grant Keddie
Taxonomy, Location Of Origin, And Health Status Of Proboscideans From Western Canada Investigated Using Stable Isotope Analysis, Jessica Z. Metcalfe, Fred Longstaffe, Christopher N. Jass, Grant D. Zazula, Grant Keddie
Earth Sciences Publications
We investigated the application of stable isotope analysis of proboscidean remains (collagen in bone/dentin/cementum and structural carbonate in enamel bioapatite) for genus-level identification of isolated specimens, assessment of geographic origins, and testing for nutritional stress. Mammoths (Mammuthus sp.) tended to have higher δ15Ncol and lower δ13Ccol than mastodons (Mammut americanum), but differences were not significant in every location. Determining the genus of isolated specimens may be possible for locations and time periods with good isotopic baselines, but environmental changes can confound interpretations. For example, an Alberta proboscidean with a δ15N …
Hyperpolarized 129xe Magnetic Resonance Imaging Of Radiation-Induced Lung Injury, Ozkan Doganay
Hyperpolarized 129xe Magnetic Resonance Imaging Of Radiation-Induced Lung Injury, Ozkan Doganay
Electronic Thesis and Dissertation Repository
Lung cancer is the largest contributor to cancer-related mortality worldwide. Only 20% of stage III non-small cell lung cancer patients survive after 5-years post radiation therapy (RT). Although RT is an important treatment modality for lung cancer, it is limited by Radiation-Induced Lung Injury (RILI). RILI develops in two phases: (i) the early phase (days-weeks) referred to radiation pneumonitis (RP), and (ii) the late phase (months). There is a strong interest in early detection of RP using imaging to improve outcomes of RT for lung cancer. This thesis describes a promising approach based on 129Xe gas as a contrast …
Dielectric Spectroscopy Of Polyvinyl Alcohol Hydrogels And Nanocomposites, Nuwansiri N.K. Getangama
Dielectric Spectroscopy Of Polyvinyl Alcohol Hydrogels And Nanocomposites, Nuwansiri N.K. Getangama
Electronic Thesis and Dissertation Repository
Gels based on polyvinyl alcohol (PVA) can be formed by repeated freezing and thawing of a solution of the polymer. PVA cryogels have applications as biomaterials, including artificial tissue and drug delivery systems. The mechanical and electrical properties of polymeric materials can be changed significantly by adding a small amount of nanometer-sized particles. In this work, the dielectric properties of PVA solutions and gels were studied in the frequency range from 10 micro Hz to 1 MHz as a function of temperature, using a dielectric spectrometer. Comparison of the dielectric constant of a PVA solution to that of water indicates …
X-Ray Absorption Fine Structure Studies Of Calcium Silicate Hydrate Biomaterials In Drug Delivery, Xiaoxuan Guo
X-Ray Absorption Fine Structure Studies Of Calcium Silicate Hydrate Biomaterials In Drug Delivery, Xiaoxuan Guo
Electronic Thesis and Dissertation Repository
Calcium silicate hydrate (CSH), a new type of bioceramics, has gained significant attention in hard tissue restoration because of their impressive role in the stimulation of osteoblast proliferation and differentiation in vitro. The further development of mesoporous bioceramics opens up new opportunities for drug delivery in hard tissue therapies. In this thesis, interaction mechanisms of drug molecules with CSH of different morphologies and CSH/polymer composites, imaging of drug distributions in CSH carriers in nanoscale, and the biomineralization mechanisms of CSH in vitro during drug release are extensively investigated using X-ray absorption near edge structure (XANES) and scanning transmission X-ray …
Exploring The Chemistry Of Phosphorus For Photopolymer Applications, Ryan Guterman
Exploring The Chemistry Of Phosphorus For Photopolymer Applications, Ryan Guterman
Electronic Thesis and Dissertation Repository
Prior to this thesis, phosphorus-containing polymers and photopolymerization represented two distinct, non-overlapping fields of study. This thesis examined the prospect of combining these two approaches to create a system possessing the benefits of both techniques. By exploiting the chemistry of phosphorus, and using photopolymerization as a fabrication method, new materials were developed and assessed for their use in various applications.
Among the many phosphorus compounds that may be used in polymer science, phosphonium salts and primary phosphines were of specific focus. First, highly fluorinated phosphonium monomers were developed to create photopolymerized hydrophobic surfaces. A structure-activity relationship was established, as both …
Peat As An Archive Of Remote Mercury Deposition In The Hudson Bay Lowlands, Ontario, Canada, William James Goacher
Peat As An Archive Of Remote Mercury Deposition In The Hudson Bay Lowlands, Ontario, Canada, William James Goacher
Electronic Thesis and Dissertation Repository
Peat from the Hudson Bay Lowlands (HBL) in Northern Ontario, Canada was used to reconstruct historical accumulation of mercury (Hg) over more than 7000 years before present. Nine cores, many with previously published paleoclimate studies, were analyzed for Hg and accumulation rates were calculated. Anthropogenic Hg enrichment factors were calculated based on accumulation rates. A more exclusive calculation of the anthropogenic enrichment factor corroborates modelling efforts that have suggested re-cycling legacy Hg is a much greater contributor to present day deposition than previously thought, but not prior to ~500 cal yrs BP. An older pre-industrial record provides a better background …