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Metal Release From A Biomedical Cocrmo Alloy In Mixed Protein Solutions Under Static And Sliding Conditions: Effects Of Protein Aggregation And Metal Precipitation, Zheng Wei, Valentine Romanovski, Luimar Filho, Cecilia Persson, Yolanda S. Hedberg

Chemistry Publications

Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses and dental implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical and chemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from, and the surface composition of, a CoCrMo alloy was investigated in physiological relevant solutions (phosphate buffered saline, PBS, with varying concentrations of fibrinogen from bovine plasma and/or bovine serum albumin) at pH 7.3 …

Patch Testing With Aluminium Finn Chambers Could Give False-Positive Reactions In Patients With Contact Allergy To Aluminium, Lisbeth Rosholm Comstedt, Jakob Dahlin, Magnus Bruze, Yolanda S. Hedberg, Mihály Matura, Cecilia Svedman

Chemistry Publications

Background

Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).

Objectives

To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.

Method

A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.

Results

A total of 5446 patients had been tested …

Ph-Sensitive Chitosan Nanoparticles For Salivary Protein Delivery, Yi Zhu, Lina M. Marin, Yizhi Xiao, Elizabeth R. Gillies, Walter L. Siqueira

Chemistry Publications

Salivary proteins such as histatins (HTNs) have demonstrated critical biological functions directly related to tooth homeostasis and prevention of dental caries. However, HTNs are susceptible to the high proteolytic activities in the oral environment. Therefore, pH-sensitive chitosan nanoparti-cles (CNs) have been proposed as potential carriers to protect proteins from enzymatic degradation at physiological salivary pH. Four different types of chitosan polymers were investigated and the optimal formulation had good batch to batch reproducibility, with an average hydrodynamic diame-ter of 144 ± 6 nm, a polydispersity index of 0.15 ± 0.04, and a zeta potential of 18 ± 4 mV at …

Gibbs Point Process Model For Young Star Clusters In M33, Dayi Li, Pauline Barmby

Physics and Astronomy Publications

We demonstrate the power of Gibbs point process models from the spatial statistics literature when applied to studies of resolved galaxies. We conduct a rigorous analysis of the spatial distributions of objects in the star formation complexes of M33, including giant molecular clouds (GMCs) and young stellar cluster candidates (YSCCs). We choose a hierarchical model structure from GMCs to YSCCs based on the natural formation hierarchy between them. This approach circumvents the limitations of the empirical two-point correlation function analysis by naturally accounting for the inhomogeneity present in the distribution of YSCCs. We also investigate the effects of GMCs' properties …