Digital Commons Network^™

Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 13 2012, Several Authors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Diet, Bacteria And Inflammation: The Intestinal Mucosa And Metabolic Syndrome, Nadeem K. Mohammed

Theses and Dissertations--Nutritional Sciences

Long term consumption of a high fat diet (HFD) increases the risk of developing Metabolic Syndrome and type 2 diabetes. This led us to hypothesize that long term HFD consumption impairs immune tolerance to the intestinal bacteria. Our studies had two goals. First, we characterized the effect of long term HFD consumption on the systemic immune response by comparing C57BL6 mice fed a HFD and low fat diet (LFD). Plasma immunoglobulin G (IgG) against Escherichia coli (LF-82), E. coli (Nissle 1917), Bacteroides thetaiotaomicron and Lactobacillus acidophilus were measured by a lab-developed ELISA. Fasting blood glucose and inflammation were measured in …

Associations Between Serum Concentrations Of Polychlorinated Biphenyls, Serum Carotenoids, And The Probability Of Metabolic Syndrome In The National Health And Nutrition Examination Survey 2003-2004, Carolyn R. Hofe

Theses and Dissertations--Nutritional Sciences

Diabetes and cardiovascular disease are leading causes of death and disability in the United States. These chronic diseases are clinical sequelae of metabolic syndrome (MetS), a condition that affects approximately one-third (1/3) of American adults. Metabolic syndrome occurs in response to environmental and genetic influences, among them food intake, a sedentary lifestyle, BMI, advancing age, and exposure to persistent organic pollutants (POPs). POPs are known to cause endocrine disruption and PCBs cause oxidative stress, disrupt endothelial cell integrity, and promote atherosclerosis. Nutrition plays a significant role in the prevention and management of these chronic diseases and has been shown to …

Deficiency Of Ace2 In Bone-Marrow-Derived Cells Increases Expression Of Tnf-Α In Adipose Stromal Cells And Augments Glucose Intolerance In Obese C57bl/6 Mice, Sean E. Thatcher, Manisha Gupte, Nicholas Hatch, Lisa A. Cassis

Graduate Center for Nutritional Sciences Faculty Publications

Deficiency of ACE2 in macrophages has been suggested to promote the development of an inflammatory M1 macrophage phenotype. We evaluated effects of ACE2 deficiency in bone-marrow-derived stem cells on adipose inflammation and glucose tolerance in C57BL/6 mice fed a high fat (HF) diet. ACE2 activity was increased in the stromal vascular fraction (SVF) isolated from visceral, but not subcutaneous adipose tissue of HF-fed mice. Deficiency of ACE2 in bone marrow cells significantly increased mRNA abundance of F4/80 and TNF-α in the SVF isolated from visceral adipose tissue of HF-fed chimeric mice, supporting increased presence of inflammatory macrophages in adipose tissue. …

Intervention Of Non-Small Cell Line Cancer Oncogenic Pathways With Delta-Tocotrienol, Xiangming Ji

Wayne State University Dissertations

Non-small cell lung cancer (NSCLC) is most hostile and leading cause of cancer deaths in the United States. Clinical data has demonstrated that 30 % of NSCLC patients have increased Notch activity and 10% of NSCLC have gain-of-function mutation on Notch-1 gene. Our data demonstrated that delta-tocotrienol could inhibit NSCLC cells proliferation, invasion and induce apoptosis by down-regulation of the Notch-1 signaling pathway. Using microRNA microarray and microRNA transfection, our findings further suggest that delta-tocotrienol is a non-toxic activator of miR-34a which can inhibit NSCLC cell proliferation, induce apoptosis, and inhibit invasion. Last but not the least, We observed that …

The Role Of Uracil-Dna Glycosylase And Folate In The Repair Of Dna, Sarah Talal Dubaisi

Wayne State University Theses

Abstract

Role of Uracil DNA-Glycosylase and Folate

In the Repair of Oxidative Damage

By

Sarah Dubaisi

May2012

Advisor: Dr. Diane Cabelof

Major: Nutrition and Food Science

Degree: Masters of Science

The impact of DNA damage on genomic integrity has been widely investigated due to its association with cancer and ageing. DNA repair pathways play a critical role in preserving the genomic integrity and protecting the cells against DNA damage caused by oxidative stress and folate deficiency. Base Excision Repair (BER) is one of the major pathways involved in the cellular response to DNA damage, primarily the damage caused by oxidative …

New Year’S Health-Check, Winston J. Craig

Lake Union Herald

No abstract provided.

Superweeds And Suspect Seeds: Does The Genetically-Engineered Crop Deregulation Process Put American Agriculture At Risk, Margaret Sova Mccabe

Law Faculty Scholarship

The federal government’s regulatory approach to genetically engineered (GE) crops, known as “The Framework”, is now twenty-five years old. Despite two and half decades of a consistent regulatory regime, GE crop and food regulation remains controversial. This article suggests that regulatory science and its tenets of independence, transparency, and public science should guide reforms of The Framework so that it is an efficient and reliable regulatory system. The article has four parts: 1) it provides a brief overview of the history of GE crop regulation; 2)it describes the key attributes of The Framework and related regulatory documents, with particular focus …

Purification Of Alpha-Glucosidase Inhibitors From Grape Extract, Gayle M. Shipp

Wayne State University Theses

ABSTRACT

PURIFICATION OF ALPHA-GLUCOSIDASE INHIBITORS FROM GRAPE EXTRACT

by

GAYLE SHIPP

August 2012

Advisor: Dr. Kevin Zhou

Major: Nutrition and Food Science

Degree: Master of Science

Diabetes and its complications are steadily growing and remain major causes of morbidity and mortality in the U.S. Intestinal á-glucosidases play a crucial role in controlling postprandial blood glucose. For this reason, one attractive prevention and/or treatment strategy for type-2 diabetes is the inhibition of á-glucosidase. The effectiveness of á-glucosidase inhibitors (AGI's) for diabetes treatment is well documented in numerous animal and human clinical studies. Grape pomace extract (GPE) has recently found in our …

Prenatal Participation In Wic : Impact On Breastfeeding Initiation And Duration And On Infant Weight Gain, Lynn S. Edmunds

Legacy Theses & Dissertations (2009 - 2024)

Background: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is one of the most studied federal food assistance programs. However, few studies have examined the association between maternal WIC participation and breastfeeding or weight gain during infancy. Prenatal WIC participation provides an important widow of influence on birth outcomes but also on early life risk factors for chronic disease. This study utilizes a cohort of WIC enrolled infants to assess the added effect of prenatal exposure to WIC on two specific outcomes - breastfeeding initiation and duration and rate of infant weight gain.

Comparison Of Exercise And Eating In Collegiate Athletes Vs. Non-Athletes Active In High School Sports, Laura Leighton Blair

Electronic Theses and Dissertations

Numerous studies have been conducted on eating disorders (ED) in collegiate athletes. Many studies conclude that collegiate athletes are more at risk of developing an ED compared to non-athletes, while some report the opposite. Purpose. To determine if collegiate athletes are more likely to exhibit ED characteristics compared to those who only participated in high school sports. Method. Each participant completed The Eating Attitude Test-26 (EAT), The Eating Disorder Inventory subscales Body Dissatisfaction (EDIBD), Drive for Thinness (EDIDFT), and Bulimia (EDIBUL) and The Body Shape Questionnaire-34 (BSQ). Group differences were examined for males (N=101), females (N=189), collegiate athletes (N=107), non-athletes …

Uracil Accumulation In Folate Depleted Mouse Embryonic Fibroblasts, Eneida Doko

Wayne State University Theses

Folate is a water-soluble vitamin B that plays a critical co-enzyme in the de novo nucleotide synthesis and other biochemical processes including DNA metabolism, DNA repair, DNA methylation, and cellular growth. Folate deficiency has been associated to increase the risk of neural tube defects (NTDs) and cancers of the lung, breast, colon, cervix, esposphagus and brain. Most importantly, folate deficiency has been shown to increase uracil misincorporation into DNA and therefore induce DNA damage repaired by the base excision repair (BER) pathway. In response to folate depletion, levels of thmidylate decrease in the deoxyribonucelotide pool, resulting in uracil being misincorporation …

The Use Of Metabolomics To Investigate Biomarker Profiles As Potential Early Risk Factors For Development Of Type Ii Diabetes Mellitus, Jennelle Lynn Arnew (Getty)

Wayne State University Theses

ABSTRACT

THE USE OF METABOLOMICS TO INVESTIGATE BIOMARKERS PROFILES AS POTENTIAL EARLY RISK FACTORS FOR DEVELOPMENT OF TYPE II DIABETES

by

JENNELLE ARNEW

MAY 2012

Advisor: Dr. Smiti Gupta

Major: Nutrition and Food Science

Degree: Masters of Science

Type 2 Diabetes affects an estimated 17.5 million individuals in the United States and is considered to be one of the most pressing public health issues of our time. To date, the exact cause of type 2 diabetes remains unclear, however, it is considered to be an interplay between environmental and genetic factors. Emerging technologies for metabolomics analysis increases the capacity to …

The Effects Of Oil Palm Phenolics On Inflammation And Oxidative Stress In Relation To Amyloid Beta Plaques In Fad-Mutant And Wild Type B103 Cells, Lindsay Michelle Godsey

Wayne State University Theses

Alzheimer's disease (AD) affects approximately 35.6 million people in the world today (35). It is expected that by year 2050, an individual will develop AD every 33 seconds (8). Unfortunately, the etiology is not well known. Familial Alzheimer's disease (FAD) occurs due to specific genetic mutations, making it possible to replicate them in cells. Using B103 rat neuroblastoma cells transfected with a cDNA construct, wild type cells and FAD mutant cells were used in this research.

Natural ingredients such as oil palm phenolics (OPP) contain antioxidants. After finding the optimal experimental parameters, OPP was found to aid in the destabilization …

Results From An Assesment Survey For School Food Service Directors And School Foodservice Managers Participating In The 2011-2012 South Carolina Farm To School Program, Maciel Ugalde

All Theses

In South Carolina (SC), children aged 10-17 are ranked 13th in the United States for overweight and obesity (33.7%) according to the National Survey of Children's Health 2007. Fruit and vegetable intake in children and adolescents in the United States is below recommended levels (Lorson, Melgar-Quinonez, & Taylor, 2009). In SC, only 15% of the high school students consume fruits and vegetables five or more times per day. Fruit and vegetable consumption has been associated with reduced risk of chronic diseases (Epstein et al., 2001; Knai, Pomerleau, Lock, & McKee, 2006; Reichmann, 2009). Schools are identified as a key setting …

Effects Of Walnut Consumption On Cognitive Performance In Young Adults, Peter Pribis, Rudolph N. Bailey, Andrew A. Russell, Marcia A. Kilsby, Magaly Hernandez, Winston J. Craig, Tevni Grajales, David J. Shavlik, Joan Sabatè

Faculty Publications

Walnuts contain a number of potentially neuroprotective compounds like vitamin E, folate, melatonin, several antioxidative polyphenols and significant amounts of n-3 α-linolenic fatty acid. The present study sought to determine the effect of walnuts on verbal and non-verbal reasoning, memory and mood. A total of sixty-four college students were randomly assigned to two treatment sequences in a crossover fashion: walnuts-placebo or placebo-walnuts. Baseline data were collected for non-verbal reasoning, verbal reasoning, memory and mood states. Data were collected again after 8 weeks of intervention. After 6 weeks of washout, the intervention groups followed the diets in reverse order. Data were …

Contents, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Nutrition Knowledge Of Pre-Medical Students, Jennifer Newcome, Cynthia Moore

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Nutrition knowledge has been shown to be increasingly critical in physician practice. Therefore, education has also become very critical. Medical schools have been working over the last few decades to include nutrition education in their curriculum, but due to many barriers, it is difficult to fulfil requirements. It is the purpose of this descriptive study to determine the nutrition knowledge of pre-medical students at the University of Arkansas and conclude if a nutrition class for these students would be beneficial. The average score of the nutrition knowledge assessment was 11.2 ± 3.04 out of a possible 23. Because the literature …

Instructions For Authors, Discovery Editors

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Exposure Of Breastfeeding Education To Ob/Gyns Currently Practicing In The State Of Mississippi And Its Effect On Confidence In Providing Breastfeeding Support To Expectant Mothers, Brandi Lee Pigg

Electronic Theses and Dissertations

There are several well documented benefits of breastfeeding for the mother and child, however, Mississippi breastfeeding rates are lacking when compared to the rest of the United States. It is believed that breastfeeding encouragement and support from prenatal healthcare providers can play a major role in mothers choosing to initiate breastfeeding. OB/GYNs should be at the forefront of this initiative because they have repeat prenatal contact with many mothers. In order to provide breastfeeding encouragement and support to expectant mothers, OB/GYNs must have adequate breastfeeding education and the confidence to support these mothers. This study analyzed the amount of breastfeeding …

The Effects Of Slow Release Urea On Nitrogen Metabolism In Cattle, Vaughn B. Holder

Theses and Dissertations--Animal and Food Sciences

The objective of this research was to investigate the effects of slow release urea on N metabolism in cattle. The ruminal behavior of Optigen®II and the effect of basal diet on the in situ degradability of urea and Optigen®II were evaluated. The effect of slow release urea and its interaction with degradable intake protein (DIP) level in the diet on N retention and excretion was evaluated utilizing 8 Holstein steers in a 4 x 4 Latin square experiment. In addition, the effect of slow release urea and DIP level on ruminal and systemic urea kinetics was evaluated using stable isotope …

An Analysis Of The Influence Of Nutrition Information On Consumers’ Restaurant Menu Choices, Joseph Adam Higgins

Theses and Dissertations--Nutrition and Food Systems

Obesity has risen drastically in the past few decades. Some experts contribute this to an increased prevalence of eating food away from home and consuming large portion sizes. A popular discussion in policy and legislation arenas has been mandatory implementation of nutrition information on restaurant chain menus. Menu labeling in restaurants that have 20 or more locations nationally was first implemented by New York City in an effort to increase consumer awareness of the calorie content of menu entrees. Since New York City’s implementation of restaurant menu labeling in 2008, there have been conflicting studies on whether nutrition menu labeling …

Kentucky Wic Participants’ Knowledge, Attitudes, And Beliefs Regarding Grains, Dustin Tyler Reed

Theses and Dissertations--Nutrition and Food Systems

Obesity, diabetes, cardiovascular disease, and poor dietary habits are major healthcare problems in the United States. These issues are especially prevalent in the state of Kentucky and among at-risk populations such as Women, Infants, and Children (WIC) participants. Studies have found that whole grains play a role in weight maintenance, protection against type 2 diabetes, and lowering cholesterol. Interventions aimed at improving WIC participant dietary behavior and intake has been successful as well. This study assessed Kentucky WIC participants’ knowledge of the benefits of consuming grains, attitudes and beliefs regarding food purchasing and grains, and identified grains consumed in a …

Obesity Related Perceptions And Practices Among Educators In The Expanded Food And Nutrition Education Program, Poonam Mahajan

Theses and Dissertations--Nutrition and Food Systems

Childhood obesity has increased significantly in the past decade. The same factors putting adults at risk for obesity apply to children as well. For children, the family environment may be one of the largest factors. Obesity affects both adults and children of low socioeconomic status. It also affects families living in the Appalachian region of the United States more frequently than other regions. The purpose of this study was to examine the relationships between obesity related behaviors and nutrition education among Appalachian participants in the Expanded Food and Nutrition Education Program (EFNEP). For this study eleven educators from the Appalachian …

Nutrition Knowledge Of Consumers And Health Professionals And The Use Of Menu Calorie Labeling, Kate Louise Perkins

Theses and Dissertations--Nutrition and Food Systems

The purpose of this study is to assess the need for menu labeling of calories based on the ability of food consumers to identify lower calorie options. By surveying consumers in Kentucky and Ohio and health professionals in Kentucky about their awareness of caloric content, basic nutrition knowledge and ability to choose lower calorie options, we can predict the potential benefit of menu labeling initiatives and the amount of education that will be necessary for consumers to effectively use menu labeling to make informed decisions on calorie intake. Through online surveys, it was determined that consumers were better able to …

Evaluation Of The Body Composition Of Female Collegiate Athletes Using The Bod Pod, Adrienne Jennifer Glodt Baker

Theses and Dissertations--Nutrition and Food Systems

The body composition of female collegiate athletes was measured using the Bod Pod® device. The sample consisted of 75 student athletes, aged 18 to 22 years old. Five sports at the university level were represented, including basketball, gymnastics, soccer, swimming & diving, and soccer. Participants were measured at the preseason and postseason periods. Overall, participants in all five sports were not found to change significantly in total body mass, fat mass, fat free mass, percent body fat, or body mass index from the preseason period to the postseason period at the alpha = 0.05 level. On average, the members from …

Environmental Perceptions And Objective Walking Trail Audits Inform A Community-Based Participatory Research Walking Intervention, Jamie Zoellner, Jennie L. Hill, Karen Zynda, Alicia D. Sample, M. Kathleen Yadrick

Faculty Publications

Background: Given the documented physical activity disparities that exist among low-income minority communities and the increased focused on socio-ecological approaches to address physical inactivity, efforts aimed at understanding the built environment to support physical activity are needed. This community-based participatory research (CBPR) project investigates walking trails perceptions in a high minority southern community and objectively examines walking trails. The primary aim is to explore if perceived and objective audit variables predict meeting recommendations for walking and physical activity, MET/minutes/week of physical activity, and frequency of trail use. Methods: A proportional sampling plan was used to survey community residents in this …

Cgi-58/Abhd5-Derived Signaling Lipids Regulate Systemic Inflammation And Insulin Action, Caleb C. Lord, Jenna L. Betters, Pavlina T. Ivanova, Stephen B. Milne, David S. Myers, Jennifer Madenspacher, Gwynneth Thomas, Soonkyu Chung, Mingxia Liu, Matthew A. Davis, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, John S. Parks, Dawn L. Brasaemle, Michael B. Fessler, H. Alex Brown, J. Mark Brown

Department of Nutrition and Health Sciences: Faculty Publications

Mutations of comparative gene identification 58 (CGI-58) in humans cause Chanarin-Dorfman syndrome, a rare autosomal recessive disease in which excess triacylglycerol (TAG) accumulates in multiple tissues. CGI-58 recently has been ascribed two distinct biochemical activities, including coactivation of adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA). It is noteworthy that both the substrate (LPA) and the product (phosphatidic acid) of the LPA acyltransferase reaction are wellknown signaling lipids. Therefore, we hypothesized that CGI-58 is involved in generating lipid mediators that regulate TAG metabolism and insulin sensitivity. Here, we show that CGI-58 is required for the generation of signaling lipids …

Muscadine Grape (Vitis Rotundifolia) And Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications In C57bl/6j Mice, Vishnupriya Gourineni, Neil F. Shay, Soonkyu Chung, Amandeep K. Sandhu, Liwei Gu

Department of Nutrition and Health Sciences: Faculty Publications

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, …

Explaining Benefit Utilization Variability In Fmnp In Kentucky: An Application Of Pierre Bourdieu’S Theory, Stephanie M. Holcomb-Kreiner

Theses and Dissertations--Sociology

Research has demonstrated the crucial role fresh fruit and vegetable consumption plays in maintaining good health. However, most Americans do not consume adequate amounts, and low-income Americans consume the lowest quantities of fresh fruits and vegetables. The Farmers’ Market Nutrition Program (FMNP) and Senior Farmers’ Market Nutrition Program (SFMNP) attempts to rectify this situation by providing vouchers to low-income women, children, and elders that can be used only at farmers’ markets for the purchase of locally grown, fresh fruits and vegetables. Unfortunately, FMNP and SFMNP exhibit variable and often low benefit utilization. This variable and often low benefit utilization is …