Digital Commons Network^™

Steroid Receptor Coactivator-1 Modulates The Function Of Pomc Neurons And Energy Homeostasis, Yongjie Yang, Agatha A Van Der Klaauw, Liangru Zhu, Tessa M Cacciottolo, Yanlin He, Lukas K J Stadler, Chunmei Wang, Pingwen Xu, Kenji Saito, Antentor Hinton, Xiaofeng Yan, Julia M Keogh, Elana Henning, Matthew C Banton, Audrey E Hendricks, Elena G Bochukova, Vanisha Mistry, Katherine L Lawler, Lan Liao, Jianming Xu, Stephen O'Rahilly, Qingchun Tong, Uk10k Consortium, Inês Barroso, Bert W O'Malley, I Sadaf Farooqi, Yong Xu

Children’s Nutrition Research Center Staff Publications

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function …

Nutrient And Food Group Intakes Of Low-Income Pregnant Women By Race/Ethnicity, Alla M. Hill, Danielle L. Nunnery Phd, Rdn, Ldn, Alice Ammerman Drph, Jigna M. Dharod Phd

Journal of Health Disparities Research and Practice

In an exploratory study, a convenience sample of 148 pregnant women was recruited from a WIC clinic in the southeast region of the U.S. to: 1) Examine and compare daily nutrient and food group intakes of WIC pregnant women to national guidelines, and; 2) Determine racial/ethnic differences in nutrient and food group intakes among WIC pregnant women. Women were selected for the study if they were: ≥ 18 y, in 2^nd trimester of pregnancy, and if they spoke English or Spanish as a first language. Upon recruitment, participants were interviewed to collect information on their socio-demographics, including race/ethnicity. Additionally, …

Body Mass Index In Multiple Sclerosis Modulates Ceramide-Induced Dna Methylation And Disease Course, Kamilah Castro, Achilles Ntranos, Mario Amatruda, Maria Petracca, Peter Kosa, Emily Y. Chen, Johannes Morstein, Dirk Trauner, Corey T. Watson, Michael A. Kiebish, Bibiana Bielekova, Matilde Inglese, Ilana Katz Sand, Patricia Casaccia

Advanced Science Research Center

Background: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS.

Methods: Fifty-four therapy-naive Relapsing Remitting (RR) MS patients with high and normal BMI received clinical and MRI evaluation. Blood samples were immunophenotyped, and processed for unbiased plasma lipidomic profiling and genome-wide DNA methylation analysis of circulating monocytes. The main findings at baseline were validated in an independent cohort of 91 therapy-naïve RRMS patients. Disease course was evaluated by a two-year longitudinal follow up …

Mycoprotein: The Future Of Nutritious Nonmeat Protein, A Symposium Review, Tim Finnigan, Benjamin Wall, Peter Wilde, Francis Stephens, Steve Taylor, Marjorie Freedman

Faculty Publications

Mycoprotein is an alternative, nutritious protein source with a meat-like texture made from Fusarium venenatum, a naturally occurring fungus. Its unique method of production yields a significantly reduced carbon and water footprint relative to beef and chicken. Mycoprotein, sold as Quorn, is consumed in 17 countries, including the United States. In line with current dietary guidelines, mycoprotein is high in protein and fiber, and low in fat, cholesterol, sodium, and sugar. Mycoprotein may help maintain healthy blood cholesterol levels, promote muscle synthesis, control glucose and insulin levels, and increase satiety. It is possible that some susceptible consumers will become …

Intuitive Eating Promotes A Healthy Lifestyle, Krista Oezer

Classical Conversations

“Intuitive eating is a dynamic process integrating attunement of the mind, body, and food.” (Tribole and Resch 23). Essentially, intuitive eating is a way of life. By listening to inner, natural signals, intuitive eating integrates mind, body, and food for optimal health. Speaking from my own personal experience, intuitive eating truly does promote a healthy lifestyle. I don’t just know about intuitive eating; I live it. I want to share my knowledge and my experience with intuitive eating to those who have never heard of it. Although intuitive eating has gained popularity, especially among dieticians and nutritionists, it still remains …

Gut Feeling: Good Food, Good Mood, Asia Battle

The Diana McDonald Writer's Challenge

In “Gut Feeling: Good Food, Good Mood,” Asia Battle describes the emerging field of nutritional psychiatry. Her essay explains why psychotropic medications can be unreliable and, over time, even counter-productive for treating ADHD, autism, bipolar disorder, and other disorders with which children are being increasingly diagnosed. Battle explains some of the science linking proper nutrition with relief from mental/emotional distress and offers suggestions for transitioning from poor diets (including the treats that we may use to placate children) to diets that promote physical and emotional well-being.

Eating Some Invasive Species Could Help To Mitigate The Impacts Of Climate Change-Related Invasions, And May Increase Future Food Security, Jesse Bull Saffeir

Independent Study Project (ISP) Collection

Climate change is predicted to increase the spread and abundance of invasive species and to erode global food security. I hypothesized that by incorporating edible invasive species into local food sheds, these two problems could help to mitigate each other. I set out to answer two questions: could eating invasive species reduce their spread and abundance? And could eating invasive species minimize the impacts of climate-change related food shocks? To answer these questions, I surveyed the existing literature on human consumption of invasive species, created a list of criteria that make an invasive species suitable for management through human consumption, …

The Keto Diet, Winston J. Craig

Lake Union Herald

No abstract provided.

The Disparity Between Scientific Consensus And American Public Opinion Of Genetically Modified Organisms And Genetic Engineering, Matthew A. Cherubino

Student Publications

Genetically modified organisms (GMOs) and genetic engineering (GE) are accepted as safe and useful by the consensus of the scientific community. Their diverse utility has shown promise in addressing major challenges of the 21st century, including world hunger, global warming, and the prevalence of diet-related diseases (e.g. heart disease, cancer, diabetes, etc.). A 2014 Pew Research Center survey revealed that while 88% of scientists agreed that GM foods were safe to eat, only 37% of American consumers agreed. Furthermore, only 35% of U.S. adults trusted scientists to accurately inform the public about GMOs. To explain this disparity, I synthesize information …

Dental Topographic Analysis Of Maxillary And Mandibular Phyllostomid Bat Dentitions: Implications For Dietary Prediction In The Fossil Record, Colin Pellegrom

Masters Theses

Mammalian dental anatomy has evolved in accordance with the physical properties of its diet, and multiple features on each tooth have specific functions related to the breakdown of food during mastication and ingestion. Tooth structure is under tight genetic control and much of the anatomical variation in dentition across species is related to adaptation to a specific dietary regime. This diet-dentition relationship can be exploited to reconstruct mammalian diets from fossil specimens through calculation of dental topographic metrics. To date, most studies of dietary reconstruction using dental topography have focused on mandibular molars; thus, this study seeks to test whether …

Cooking Frequency Associated With Dietary Quality In Icook-4h Youth Participants At Baseline, Amber D. Ford, Sarah E. Colby, Marissa Mcelrone, Lisa Franzen-Castle, Melissa D. Olfert, Kendra K. Kattelmann, Adrienne A. White

Health and Nutritional Sciences Faculty Publications

Background: Increased intakes of ready-made and fast foods paralleled with decreased homemade food consumption have been associated with increased rates of obesity. Researchers have shown associations between cooking self-efficacy (SE) and cooking frequency (CF) with dietary quality and weight status. Some cooking interventions have shown positive associations with dietary outcomes, such as increased fruit and vegetable intake and decreased fast food consumption. There is still much unknown about SE and CF, especially among youth.
Objective: Determine baseline SE and CF and the associations with dietary quality and body mass index (BMI) of youth enrolled in iCook 4H.
Methods: Youth (n=228, …

Is Breastfeeding Truly Best? Evolutionary, Physiological, & Cultural Factors That Shape Breastfeeding Practices, Emily J. Green 19

Honor Scholar Theses

No abstract provided.

An Observational Study Of Physicochemical Changes In Cheddar Enzyme-Modified Cheese During Incubation, David Gary Doxey

Theses and Dissertations

This study is an observation of the various physicochemical changes that occur in enzyme-modified cheese (EMC) during the incubation step of production. The purpose of this study was an attempt to gain a better understanding of the changes that occur due to enzymatic reactions during EMC production. A standard EMC batch was prepared with the addition of two exogenous enzymes, a lipase and a protease (LP). Two additional treatment batches had either only a lipase (L) or a protease (P) added individually. Batches were prepared in duplicate with each replicate performed on different days. Each batch was incubated at 42±0.5°C …

Stop The War On Veggies, Une Applied Nutrition Program

All Student-Created Educational Resources

This pamphlet gives parents and caretakers of young children information on creating a food environment for children that promotes vegetable consumption. It further gives some tips on ways to engage children and make eating vegetables fun.

How To Prevent High Blood Pressure, Une Applied Nutrition Program

All Student-Created Educational Resources

This handout informs the audience about how to prevent high blood pressure naturally. It includes information on diet and exercise; healthy defaults to prevent high blood pressure; tips on avoiding sodium and alcohol and risk factors for high blood pressure.

The Culinary Culture Of Iran Fact Sheet, Rachael Costello

All Student-Created Educational Resources

A two-page handout detailing the food customs and cultures of The Islamic Republic of Iran. This includes traditional dishes, meals, culinary influences, religious dietary rules, and common eating patterns.

Planning For Success, Robin Verzoni

All Student-Created Educational Resources

This pamphlet informs the reader about meal preparation and planning. It gives examples of healthy food options from the various categories of macro nutrients, and quick and healthy snack options. It stresses the importance of planning ahead and how important it is to be successful. It gives examples of ways to have handy meals and snacks for work and discusses the importance of bringing awareness to what you eat by tracking your daily intake.

Simple Strategies For A Healthy Pregnancy, Une Applied Nutrition Program

All Student-Created Educational Resources

This handout gives the audience ideas for meeting the nutritional needs of teens for a healthy pregnancy. Tips for incorporating healthy foods and physical activity into a regular routine are included. The importance of nutrition during an adolescent pregnancy is briefly overviewed.

Prevent The Progression Of Gestational Diabetes After Pregnancy, Yasmin Barakat

All Student-Created Educational Resources

This handout informs the audience about ways to reduce the risk of or even prevent the progression of gestational diabetes into needing insulin medication or after pregnancy. This will include tips on healthy defaults for dietary and lifestyle modifications such as making healthy alternatives easy and more attractive, as well as the role of physical activity in diabetes prevention, and maintaining weight. It will also include information on nutrient needs while pregnant.

Easy Adjustments To Create Success In Your Health Journey, Stephanie Menagh

All Student-Created Educational Resources

This handout informs readers about different ways to utilize healthy defaults in daily life. Definition of healthy defaults, prevalence and concerns with obesity, and methods to create small everyday lifestyle changes are discussed.

Teen Obesity: Solutions To Address The Nutritional And Socio-Economic Factors, Jaya Balasubramanian

All Student-Created Educational Resources

This handout provides solutions to the various challenges facing obese teenagers ranging from how to eat right, plan out the day’s nutrition, smart way to choose school meals, tips to manage weight, how to eat less calories and still feel satiated, including workouts to the daily regimen, cooking at home and lastly, managing the monthly budget to allow finances for grocery and food till the month end.

Taking Charge Of Adolescent Obesity, Katelyn Gass

All Student-Created Educational Resources

This handout provides basic information and simple tips to work on the overall health and well-being of the obese adolescent through evidence based research.

Vietnam Food Culture, Candace Nelson

All Student-Created Educational Resources

The food scene in Vietnam is social and lively. The demand for fresh meat, seafood, and produce has open-air markets open twice per day. The demand for freshness also limits opportunities to enforce food safety regulations. Vietnam has one of the highest rates of vegetable consumption in the world. Rice is also consumed in large portions, but malnourishment rates are high. Common deficiencies include vitamin A, iron, iodine, and zinc. Honoring the dead through food is a common practice.

Childhood Obesity: What You Can Do For Your Child, Gabrielle Parks

All Student-Created Educational Resources

This handout provides information to parents regarding the causes of obesity. It provides several ways parents can help prevent obesity in their children as well as health outcome should children remain obese into adulthood.

Define Your Life In A Whole New Way, Une Applied Nutrition Program

All Student-Created Educational Resources

Childhood obesity has become a relatively recent problem, but affects a large portion of the American children population. The diet of American children is setting them up for failure. It is helping them to become overweight or obese instead of becoming strong and healthy into their adult years.

Small Changes Make A Big Difference, Jessica Crone

All Student-Created Educational Resources

This handout gives six tips to adolescent females on how to create healthy habits to fight obesity that focuses on other things than just eating healthy.

Sensory Acceptability And Nutrient Stability In Micronutrient-Fortified Soymilk Prepared In Small-Scale Batch Processes, Dallin Max Hardy

Theses and Dissertations

Fortified and unfortified soymilk were produced from the same production batches for comparative evaluation. Fortification included a comprehensive array of micronutrients of interest to community and humanitarian nutrition programs. The effects of time after fortification prior to cooling, cooling method, and light or dark refrigerated storage on the stability of 5 vitamins (vitamin A, vitamin C, thiamine, riboflavin, and folate) were investigated for both fortified and unfortified soymilk. Significant vitamin C loss (6%) and mild vitamin A isomerization occurred while soymilk was hot immediately following fortification. Cooling bottled soymilk in an ambient water bath or ice water bath made no …

Elevating Communities Into Self-Sufficiency Through Federally-Funded Health Partnerships, Nalleli Martinez

Master's Projects and Capstones

Purpose: This qualitative study is to identify programing that encourages increased self-sufficiency in SNAP recipients. The goal was to identify themes related to successful self-sufficiency programming at federally-funded health centers/health programs (HCHPs). The study also investigated the role of social determinants of health in relation to achieving self-sufficiency.

Method: A series of 45-minute to 1-hour-long interviews were conducted to explore the perspectives of seven total staff at seven federally-funded HCHPs across the U.S. western region. Using Nvivo, a qualitative data analysis software, responses were categorized into six themes: patient-centered care, one-stop-shop/integrated care model, community partnerships, organizational and staff support, leadership …

Effects Of A Postural Restoration Focused Intervention On Muscle Activation During Deadlifts, Caleb Richardson

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to determine the efficacy of implementing two Postural Restoration exercises and relating principles on deadlifts using a hexagonal barbell. Specifically, we aimed to examine the effects of the intervention on muscle activation and the location of the ground reaction force (GRF) center of pressure. Sixteen subjects (age 18-35 yrs.; male (n=14); female (n=2)), with at least 1 year of deadlifting experience, were randomly assigned into a control and intervention group (both n=8). Both groups performed two sets of three repetitions of deadlifts at 50% and at 80% of their estimated one repetition maximum (1-RM). …

Comparison Of Cardiorespiratory Fitness Prediction Models In Young Adults Running Head: Comparison Of Vo2 Max Prediction Models, Elizabeth Ann Tanner, James W. Navalta

Kinesiology and Nutrition Sciences Faculty Research

To compare the predictive accuracy of regression models for a non-consecutive day VO2 max/Wingate testing protocol and a same day testing protocol. Participants (N=23) completed a treadmill GXT and Wingate cycle test. Participants (n=12) completed testing on non-consecutive days (NON) and (n=11) the same day (SAME). VO2 max (L/min) and peak power (PP) were collected. Linear regression analysis of NON revealed R2=0.808 and prediction equation Ŷ=1.499+0.004X and SAME showed R2=0.861 and prediction equation Ŷ=1.407+0.003X. NON standard error of estimate (SEE) and standard error of estimate percent (SEE %) were 0.62 L/min and 15.23%, respectively. SAME SEE and SEE% were 0.34 …