Digital Commons Network^™

Characteristics Of Eating Behavior Profiles Among Preschoolers With Low-Income Backgrounds: A Person-Centered Analysis, Jennifer Orlet Fisher, Sheryl O Hughes, Alison L Miller, Mildred A Horodynski, Holly E Brophy-Herb, Dawn A Contreras, Niko Kaciroti, Karen E Peterson, Katherine L Rosenblum, Danielle Appugliese, Julie C Lumeng

Children’s Nutrition Research Center Staff Publications

Background: Individual differences in eating behaviors among young children are well-established, but the extent to which behaviors aggregate within individuals to form distinct eating behavior profiles remains unknown. Our objectives were to identify eating behavior profiles among preschool-aged children and evaluate associations with temperament and weight.

Methods: A secondary, cross-sectional analysis of baseline data from 2 cohort studies was conducted involving 1004 children aged 3-4 years and their parents with low-income backgrounds. Children's eating behaviors and temperament were assessed by parental report. Body mass index z-scores and weight status were calculated using measured heights and weights. Latent profile analysis (LPA) …

A Commentary On The Healthy Community Stores Case Study Project: Implications For Retailers, Policy, And Future Research, Samantha M. Sundermeir, Megan R. Winkler, Sara John, Uriyoán Colón-Ramos, Ravneet Kuar, Ashley Hickson, Rachael D. Dombrowski, Alex B. Hill, Bree Bode, Julia Deangelo, Joel Gittelsohn

Urban Studies and Planning Faculty Research Publications

In the United States, low-income, underserved rural and urban settings experience poor access to healthy, affordable food. Introducing new food outlets in these locations has shown mixed results for improving healthy food consumption. The Healthy Community Stores Case Study Project (HCSCSP) explored an alternative strategy: supporting mission-driven, locally owned, healthy community food stores to improve healthy food access. The HCSCSP used a multiple case study approach, and conducted a cross-case analysis of seven urban healthy food stores across the United States. The main purpose of this commentary paper is to summarize the main practice strategies for stores as well as …

Epixplorer: A Web Server For Prediction, Analysis And Visualization Of Enhancer-Promoter Interactions, Li Tang, Zhizhou Zhong, Yisheng Lin, Yifei Yang, Jun Wang, James F Martin, Min Li

Children’s Nutrition Research Center Staff Publications

Long distance enhancers can physically interact with promoters to regulate gene expression through formation of enhancer-promoter (E-P) interactions. Identification of E-P interactions is also important for profound understanding of normal developmental and disease-associated risk variants. Although the state-of-art predictive computation methods facilitate the identification of E-P interactions to a certain extent, currently there is no efficient method that can meet various requirements of usage. Here we developed EPIXplorer, a user-friendly web server for efficient prediction, analysis and visualization of E-P interactions. EPIXplorer integrates 9 robust predictive algorithms, supports multiple types of 3D contact data and multi-omics data as input. The …

Ong-Term Effects Of Developmental Exposure To Oxycodone On Gut Microbiota And Relationship To Adult Behaviors And Metabolism, Zhen Lyu, Robert R. Schmidt, Rachel E. Martin, Madison T. Green, Jessica A. Kinkade, Jiude Mao, Nathan J. Bivens, Trupti Joshi, Cheryl S. Rosenfeld

Biomedical Sciences

Opioid drugs are commonly prescribed analgesic to pregnant women. Direct exposure to such drugs may slow gut motility, alter gut permeability, and affect the gut microbiome. While such drugs affect gut microbiome in infants, no study to date has determined whether developmental exposure to such drugs results in longstanding effects on gut microbiota and correspondingly on host responses. We hypothesized developmental exposure to oxycodone (OXY) leads to enduring effects on gut microbiota and such changes are associated with adult neurobehavioral and metabolic changes. Female mice were treated daily with 5 mg OXY/kg or saline solution (control [CTL]) for 2 weeks …

The Effect Of Interventions To Prevent Type 2 Diabetes On The Development Of Diabetic Retinopathy: The Dpp/Dppos Experience, Neil H White, Qing Pan, William C Knowler, Emily B Schroeder, Dana Dabelea, Emily Y Chew, Barbara Blodi, Ronald B Goldberg, Xavier Pi-Sunyer, Christine Darwin, Mathias Schlögl, David M Nathan

Children’s Nutrition Research Center Staff Publications

Objective: To determine whether interventions that slow or prevent the development of type 2 diabetes in those at risk reduce the subsequent prevalence of diabetic retinopathy.

Research design and methods: The Diabetes Prevention Program (DPP) randomized subjects at risk for developing type 2 diabetes because of overweight/obesity and dysglycemia to metformin (MET), intensive lifestyle intervention (ILS), or placebo (PLB) to assess the prevention of diabetes. During the DPP and DPP Outcome Study (DPPOS), we performed fundus photography over time on study participants, regardless of their diabetes status. Fundus photographs were graded using the Early Treatment Diabetic Retinopathy Study grading system, …

An Analysis Of The Recent Us Dietary Guidelines Process In Light Of Its Federal Mandate And A National Academies Report, Cheryl Achterberg, Arne Astrup, Dennis M Bier, Janet C King, Ronald M Krauss, Nina Teicholz, Jeff S Volek

Children’s Nutrition Research Center Staff Publications

The US Dietary Guidelines for Americans is an enormously influential policy that has guided US nutrition programs since 1980. During these last 40 years, some researchers have expressed concern that the guidelines are based on an insufficiently rigorous assessment of the scientific evidence, a view that was largely substantiated by a Congressionally mandated 2017 report by the National Academies of Sciences, Engineering, and Medicine, which identified a need for enhanced transparency, greater scientific rigor, and updates to the scientific methodology for the DGA process. This paper traces the history of these ideas and contextualizes the DGA within the law and …

Micronutrient Fortified Soymilk Processing Supplemental Data Tables, Michael L. Dunn, Oscar A. Pike, Bradley J. Taylor, Dallin M. Hardy

ScholarsArchive Data

This data set contains Supplemental Tables (created using Microsoft Word) for the following manuscript submitted for publication:

Vitamin stability and sensory acceptability in micronutrient-fortified soymilk prepared by small-scale batch processing

Authors: Dallin M. Hardy, Oscar A. Pike, Bradley J. Taylor, Michael L. Dunn

The above manuscript was prepared with modifications from portions of the M.S. thesis of Dallin M. Hardy, which can be found at: https://scholarsarchive.byu.edu/etd/8284/

The data set includes five supplementary tables containing data values for vitamin retention during processing and sensory acceptance of micronutrient fortified soymilk. The data in these tables had no statistically significant differences between treatments.

Lama Rawat Inap Pasien Terkonfirmasi Covid-19 Di Rumah Sakit Universitas Indonesia Dan Faktor Yang Mempengaruhinya., Rizka Fahmia, Helda Helda

Jurnal Epidemiologi Kesehatan Indonesia

Banyaknya kasus COVID-19 membuat daya tampung fasilitas kesehatan hampir tidak mencukupi untuk memberikan pelayanan medis rawat inap yang memadai pada pasien COVID- 19. Studi yang dilakukan di beberapa negara seperti China, Beijing, Vietnam, Amerika Serikat melaporkan durasi dan faktor risiko rawat inap pasien COVID-19 yang bervariasi. Namun, saat ini penelitian tentang durasi dan faktor risiko lama rawat inap pasien COVID-19 di Indonesia masih terbatas. Penelitian bertujuan mengetahui faktor risiko lama rawat inap pasien terkonfirmasi COVID-19 di Rumah Sakit Universitas Indonesia (RSUI). Desain studi potong lintang dilakukan pada 266 pasien terkonfirmasi COVID-19 yang dirawat inap di RSUI selama Maret sampai dengan …

Hubungan Tingkat Pendidikan Dengan Resiliensi Keluarga Penderita Stroke Iskemik Serangan Pertama Di Rs Otak Dr. Drs. M. Hatta (Rsomh) Bukittinggi 2022, Helda Helda

Jurnal Epidemiologi Kesehatan Indonesia

Penyakit stroke menjadi salah satu penyebab kematian tertinggi dan merupakan penyumbang ketiga kecacatan secara global. Jenis stroke yang paling umum terjadi di Indonesia adalah stroke iskemik. Sebagian besar penderita stroke mengalami penurunan kognitif dan motorik yang menyebabkan keterbatasan pada penderitanya dalam melakukan aktivitas sehingga keluarga memegang peranan penting pada kondisi penderita stroke. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pendidikan dengan resiliensi keluarga penderita stroke iskemik serangan pertama. Penelitian ini adalah studi kuantitatif dengan desain penelitian cross-sectional yang menggunakan data primer pada bulan Januari-Februari 2022 di poli rawat inap Rumah Sakit Otak Dr. Drs. M. Hatta Bukittinggi (RSOMH). Sampel penelitian …

Trend Of Non-Pharmacological Therapy For First Phase Of Active Labor Pain: A Pilot Study, Agus Gunadi, Nurhayati Adnan Prihartono

Jurnal Epidemiologi Kesehatan Indonesia

There are several of non-pharmacological therapies to be used as caring practice to mother with labor pain. This study aimed to observe the effectiveness of both single and combination therapy of warm compresses and counter pressure massage (CPM) for the management of labor pain during the first active phase through medical records. This is a pilot study that used a cohort prospective design. The total number of respondents was 90 respondents, divided into 3 groups based on the non-pharmacological therapy that was given by the midwives or nurses. Pain level was measured with NRS 11. The study was conducted at …

Frekuensi Dan Mortalitas Pasien Sepsis Dan Syok Septik Di Icu Rumah Sakit Swasta Tipe B, Di Tangerang Selatan, Abioso Wicaksono, Asri Adisasmita Prof

Jurnal Epidemiologi Kesehatan Indonesia

Syok septik, yang didefinisikan sebagai sepsis dengan abnormalitas pada system sirkulasi and selular atau metabolic, masih merupakan salah satu penyebab kematian di Intensive Care Unit (ICU) secara global (20%). Studi kros-seksional ini bertujuan untuk mengetahui frekuensi, faktor risiko syok septik dan mortalitas pada pasien sepsis yang dirawat di ICU di Indonesia. Sampel dikumpulkan dari RS tipe B di Tangerang Selatan, Banten tahun 2020. Data yang dikumpulkan terdiri dari tempat infeksi, komorbiditas: Diabetes Melitus (DM) II, hipertensi, penyakit paru obstruksi kronis dan penyakit ginjal Kronis, asal unit sebelum masuk ICU, Glasgow Coma Score (GCS), acute respiratory distress syndrome (ARDS), lama rawat …

Hubungan Karakteristik Ibu Dengan Sikap Responsif Anak, Yuri Nurdiantami

Jurnal Epidemiologi Kesehatan Indonesia

Sikap responsif seorang anak terhadap ibunya merupakan salah satu sikap yang akan terbentuk melalui pola pengasuhan. Pola asuh tidak terlepas dari karakterstik dalam diri orang tua, terlebih ibu. Karakteristik tersebut memberi warna dalam pola asuh yang diterapkan pada anak. Berdasarkan hal tersebut, studi ini bertujuan untuk meneliti hubungan antara karakteristik ibu dengan sikap responsif pada anak. Studi ini menggunakan desain penelitian cross sectional. Pengumpulan data dilakukan dengan metode online survey dan wawancara yang disertai observasi. Subjek studi sebanyak 88 responden. Sikap responsif anak dilihat dari reaksi yang kuat selama berinteraksi dengan ibu maupun bertutur atau berceloteh dengan ibu atau pengasuh. …

Associations Of Dietary Antioxidants With Glycated Hemoglobin And Insulin Sensitivity In Adults With And Without Type 1 Diabetes, Arpita Basu, Amy C. Alman, Janet K. Snell-Bergeon

Kinesiology and Nutrition Sciences Faculty Research

Type 1 diabetes (T1D) has been associated with increased risks of atherosclerotic cardiovascular disease, and poor glycemic control and oxidative stress play a major role in its pathology. There is a lack of data on the role of dietary antioxidant micronutrients, including vitamins and trace elements, in glycemic control in T1D. The aim of this study is to examine associations of dietary intakes of micronutrients with glycemic status. We report data from a cross-sectional analysis from the coronary artery calcification in type 1 diabetes (CACTI) study (n = 1257; T1D: n = 568; nondiabetic controls: n = 689) collected between …

Urinary Aflatoxin M1 Concentration And Its Determinants In School-Age Children In Southern Ethiopia, Tafere Gebreegziabher Belay, Melanie Dean, Elilta Elias, Workneh Tsegaye, Barbara J. Stoecker

All Faculty Scholarship for the College of Education and Professional Studies

Aflatoxins are mycotoxins that can contaminate grains, legumes, and oil seeds. These toxic compounds are an especially serious problem in tropical and sub-tropical climates. The objective of this study was to raise awareness of aflatoxin exposure among primary school children in Shebedino woreda, southern Ethiopia, by measuring urinary aflatoxin M1 (AFM1). The study employed a cross-sectional design and systematic random sampling of children from eight schools in the district. The mean ± SD age of the children was 9.0 ± 1.8 years. Most (84.6%) households were food insecure with 17.9% severely food insecure. Urinary AFM1 was detected in more than …

Overweight And Obesity Challenges Among African Americans In Rural Alabama Black Belt, Joel Tumwebaze, Johnpaul Kagulire, Norma L. Dawkins

Journal of Extension

This study aimed at averting challenges of overweight and obesity among African Americans in rural Alabama. Focus group discussions and surveys were used to design a 12-week nutrition education and physical activity program. Results showed a significant improvement (p<0.05) in participants’ knowledge scores. Values for systolic blood pressure significantly reduced (p<0.00). There was an increase in number of participants with normal blood pressure and a reduction in number of participants with stage 2 hypertension. The study highlights that nutrition education and physical activity can lead to improved health outcomes among African Americans in rural Alabama.

Improving Growth And Yield Of Sunflower With Integrated Use Of Compost And Pgpr (Variovorax Paradoxus) With Different Levels Of N-Chemical Fertilizer, Muhammad Imran, Muhammad Javed Akhtar, Sarmad Frogh Arshad, Muhammad Ashfaq, Muhammad Zeeshan Gulzar, Hafiz Shahzad Ahmad, Kashif Bashir, Zulqurnain Khan, Hasan Riaz, Tanveer Ul Haq

Journal of Bioresource Management

Plant growth-promoting rhizobacteria (PGPRs) stimulate plant growth through their ability, to increasing the root length and growth, by asymbiotic nitrogen fixation, by producing siderophores, solubilization of mineral phosphates and mineralization of other nutrients. Organic waste material of fruits and vegetables was collected and composted in a locally fabricated composting unit. A pot trial was conducted to study the effectiveness of compost and PGPR (Variovorax paradoxus) with recommended rate of PK and with different rates of N fertilizer i.e. 50 %, 75 % and 100 %, on growth and yield of sunflower. Results showed that the integrated use of …

An Analysis Of Available European Food Composition Databases To Enable The Development Of A Technology-Based Dietary Assessment Tool, Hannah Al-Sehaim

ORBioM (Open Research BioSciences Meeting)

DIETARY DEAL is an EU-project led by MTU, tasked to develop an open-source dietary assessment tool (DAT) to harmonise collection and analysis of dietary data across Europe⁽¹⁾. A key component of all DATs is integrated food composition databases (FCD) containing energy and nutrient information (per 100g food) for translation of food intake data into nutrient estimates.

This preliminary research aimed to identify and quantify available FCD in European countries for inclusion in the new DAT.

Search terms such as [European Food Composition Databases], [Available Food Composition Databases in Europe] and [Recent European Food Composition Databases Published] were used …

Dietary Fibre Intake In Teenagers (13-18 Years) Living In Ireland, Cliodhna Mcgowan

ORBioM (Open Research BioSciences Meeting)

Dietary fibre (DF) plays a major role in normal bowel function and low intakes have been reported globally for all population groups including teenagers. The aim of this study was to use new data from the National Teens’ Food Survey II (2019-20) to estimate intake and sources of DF for teenagers in Ireland.

Dietary intake data were collected using a 4d weighed food-diary and DF intake was estimated using UK and Irish food composition data. The mean daily intake (MDI) of DF was calculated via the NCI-method and compared with the adequate intake (AI) of 19g/d (13-14-year-olds) , 21g/d 1(5-17-year-olds) …

Context Matters: Preliminary Evidence That The Association Between Positive Affect And Adiposity In Infancy Varies In Social Vs Non-Social Situations, Alexis C Wood, Shabnam R Momin, Mackenzie K Senn, David J Bridgett

Children’s Nutrition Research Center Staff Publications

Previous studies have suggested that infants high in negative affect have higher levels of adiposity, arising in part via changes in nutrition (e.g., “feeding to soothe”). Few studies have examined whether positive affect shows similar or inverse associations with adiposity. The current study examined cross-sectional and longitudinal relationships between adiposity and observations of positive affect in both a social and a non-social context, using data from infants at four (n = 125) and 12 (n = 80) months of age. Our analyses did not find any cross-sectional associations between positive affect and adiposity (all p > 0.05). However, in the longitudinal …

Tomatoes, Lycopene, And Prostate Cancer: What Have We Learned From Experimental Models?, Nancy E Moran, Jennifer M Thomas-Ahner, Lei Wan, Krystle E Zuniga, John W Erdman, Steven K Clinton

Children’s Nutrition Research Center Staff Publications

Human epidemiology suggests a protective effect of tomatoes or tomato phytochemicals, such as lycopene, on prostate cancer risk. However, human epidemiology alone cannot reveal causal relations. Laboratory animal models of prostate cancer provide opportunities to investigate hypotheses regarding dietary components in precisely controlled, experimental systems, contributing to our understanding of diet and cancer risk relations. We review the published studies evaluating the impact of tomatoes and/or lycopene in preclinical models of prostate carcinogenesis and tumorigenesis. The feeding of tomatoes or tomato components demonstrates anti-prostate cancer activity in both transplantable xenograft models of tumorigenesis and models of chemically- and genetically-driven carcinogenesis. …

French-Fried Potato Consumption And Energy Balance: A Randomized Controlled Trial, Daniel L Smith, Rebecca L Hanson, Stephanie L Dickinson, Xiwei Chen, Amy M Goss, John B Cleek, W Timothy Garvey, David B Allison

Children’s Nutrition Research Center Staff Publications

Background: Epidemiologic observations suggest increased potato consumption correlates with weight gain, adiposity, and diabetes risk, whereas nut consumption is associated with weight control and metabolic health. Randomized controlled trial (RCT) data indicate humans respond to changes in energy intake in single dietary components and compensate for extra energy consumed.

Objectives: We completed an RCT testing whether increased daily potato consumption influences energy balance [specifically, fat mass (FM)] compared with calorie-matched almond consumption.

Methods: A 30-d RCT of 180 adults prescribed calorie-matched (300 kcal/d, n = 60 participants/group) than consumed 1 of the following: 1) almonds (almond group), 2) French fries …

The Effects Of Vitamin D Supplementation On Athletic Performance And Injury Prevention, Amani Adeeb Abushamma

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Vitamin D supplementation has numerous effects on athletic performance and plays a significant role in preventing an athlete’s risk of getting injuries. Vitamin D has an impact on numerous physiological functions such as: bone health, muscle function, inflammatory response, and immune function. An athlete’s bone and muscle health are essential for maximum performance and career success. A bone fracture due to vitamin D deficiency can delay an athlete’s training and ultimately inhibit obtaining a collegiate scholarship and/or contract. A cross sectional study found that more than half of athletic trainers did not view 25-hydroxyvitamin D(25[OH]) testing and vitamin D supplementation …

Create Better Health Curriculum, Casey Coombs, Jaqueline Neid

All Current Publications

CBH is a comprehensive nutrition curriculum designed to teach adult SNAP-Ed participants how to eat well and be active on a budget. CBH combines nutrition and physical activity recommendations from United States Department of Agriculture (USDA). Each lesson has three components: a nutrition topic based on the current Dietary Guidelines for Americans, a physical activity discussion based on USDA recommendations, and a Create recipe demonstration and sample. The components are woven together in eight lessons that are designed to keep participants engaged, while actively learning the skills needed to create a healthier lifestyle.

Characterization Of Severity In Zellweger Spectrum Disorder By Clinical Findings: A Scoping Review, Meta-Analysis And Medical Chart Review, Mousumi Bose, Christine Yergeau, Yasmin D’Souza, David D. Cuthbertson, Melisa J. Lopez, Alyssa K. Smolen, Nancy E. Braverman

Department of Nutrition and Food Studies Scholarship and Creative Works

Zellweger spectrum disorder (ZSD) is a rare, debilitating genetic disorder of peroxisome biogenesis that affects multiple organ systems and presents with broad clinical heterogeneity. Al-though severe, intermediate, and mild forms of ZSD have been described, these designations are often arbitrary, presenting difficulty in understanding individual prognosis and treatment effectiveness. The purpose of this study is to conduct a scoping review and meta-analysis of existing literature and a medical chart review to determine if characterization of clinical findings can predict severity in ZSD. Our PubMed search for articles describing severity, clinical findings, and survival in ZSD resulted in 107 studies (representing …

Diet And Nutrition Of Lemurs In The Lean Season, Santiago Cassalett

Dissertations, Theses, and Capstone Projects

Animals must navigate complex food and nutrient environments that are constantly in flux to obtain the macro and micronutrients necessary for their growth, reproduction, and survival. The nutritional needs of animals also vary over the life course, further complicating the search for adequate foods and the nutrients within them. The hypervariable and unpredictable environment of Madagascar creates a complex nutrient landscape for lemurs in particular because they are subject to large fluctuations in food availability. These fluctuations are thought to create extreme periods of nutritional stress during the dry season (known as the lean season) for lemurs. In response, lemurs …

Associations Between Adherence To The Dietary Approaches To Stop Hypertension (Dash) Diet And Six Glucose Homeostasis Traits In The Microbiome And Insulin Longitudinal Evaluation Study (Miles), Gautam Ramesh, Alexis C Wood, Matthew A Allison, Stephen S Rich, Elizabeth T Jensen, Yii-Der I Chen, Jerome I Rotter, Alain G Bertoni, Mark O Goodarzi

Children’s Nutrition Research Center Staff Publications

Background and aims: The DASH diet conveys protection against type 2 diabetes mellitus (T2D) Via plant-based and non-plant-based recommendations. Research has not identified which glucose homeostasis pathways are improved. We examined associations between adherence to a DASH diet and six glucose homeostasis traits, probing whether associations could be attributed to the plant-based (DASH-P) and/or non-plant based (DASH-NP) components.

Methods and results: We included data from 295 adults without T2D (age 59.3 ± 9.00 years; 63.46% non-Hispanic White and 36.54% African American, self-reported race ancestry) participating in the Microbiome and Insulin Longitudinal Evaluation Study (MILES). An oral glucose tolerance test (OGTT) …

Circadian Disruption Of Hippocampus In An Early Senescence Male Mouse Model, Jennifer A Davis, Jodi R Paul, Mugdha V Mokashi, Stefani A Yates, Daniel J Mount, Hira A Munir, Lacy K Goode, Martin E Young, David B Allison, Karen L Gamble

Children’s Nutrition Research Center Staff Publications

Age-related cognitive decline and disruptions in circadian rhythms are growing problems as the average human life span increases. Multiple strains of the senescence-accelerated mouse (SAM) show reduced life span, and the SAMP8 strain in particular has been well documented to show cognitive deficits in behavior as well as a bimodal pattern of circadian locomotor activity. However, little is known about circadian regulation within the hippocampus of these strains of mice. Here we test the hypothesis that in this early senescence model, disruption of the molecular circadian clock in SAMP8 animals drives disrupted behavior and physiology. We found normal rhythms in …

The Effect Of Reduced Cp, Synthetic Amino Acid Supplemented Diets On Growth Performance And Nutrient Excretion In Wean To Finish Swine, Caitlin E Vonderohe, Kayla M Mills, Shule Liu, Matthew D Asmus, Emily R Otto-Tice, Brian T Richert, Ji-Qin Ni, John Scott Radcliffe

Children’s Nutrition Research Center Staff Publications

Mixed sex pigs (n = 720) were placed in 12 rooms (Purdue Swine Environmental Research Building) to measure the effect of reduced crude protein (CP), amino acid (AA)-supplemented diets on growth and the carcass. Pigs were blocked by body weight (BW) and gender and allotted to room and pen (10 mixed-sex pigs/pen). Pigs were fed a nine-phase, wean-finish program. Control pigs consumed corn-soybean meal-distiller’s dried grains with solubles (DDGS) diets containing no to minimal (Met) synthetic AA. The 2X diet was formulated to meet the seventh most-limiting AA, and balanced using synthetic AAs to meet all AA needs. The …

An Exercise-Inducible Metabolite That Suppresses Feeding And Obesity, Veronica L Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T Kim, Amanda L Wiggenhorn, Julia T Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H Zushin, Robert S Jansen, Basil Michael, Kang Yong Loh, Andrew C Yang, Christian S Carl, Christian T Voldstedlund, Wei Wei, Stephanie M Terrell, Benjamin C Moeller, Rick M Arthur, Gareth A Wallis, Koen Van De Wetering, Andreas Stahl, Bente Kiens, Erik A Richter, Steven M Banik, Michael P Snyder, Yong Xu, Jonathan Z Long

Children’s Nutrition Research Center Staff Publications

Exercise confers robust protection against obesity, type 2 diabetes, and other cardiometabolic diseases.1–5 However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear.6 Here we show that exercise stimulates production of Lac-Phe, a blood-borne signaling metabolite that suppresses feeding and obesity. Lac-Phe biosynthesis from lactate occurs in CNDP2+ cells including immune cells, epithelial cells, and mesenchymal stem cells localized to diverse organs. In diet-induced obese mice, pharmacological elevation of circulating Lac-Phe reduces food intake without affecting movement or energy expenditure. Chronic administration of Lac-Phe decreases adiposity and body weight and …

The Hypothalamus For Whole-Body Physiology: From Metabolism To Aging, Tiemin Liu, Yong Xu, Chun-Xia Yi, Qingchun Tong, Dongsheng Cai

Children’s Nutrition Research Center Staff Publications

Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing …