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Articles 9811 - 9840 of 326697
Full-Text Articles in Entire DC Network
Hiv Infection, Neurotoxicity, Inflammation, Premature Aging, And Therapeutic Challenges To Plwh: An Overview, Mudit Tyagi, Ulhas P. Naik, Kratika Tyagi, Madhulika Sharma, Gagan Kaushal, Alok Bhushan, Michael Bukrinsky, Priya Tyagi
Hiv Infection, Neurotoxicity, Inflammation, Premature Aging, And Therapeutic Challenges To Plwh: An Overview, Mudit Tyagi, Ulhas P. Naik, Kratika Tyagi, Madhulika Sharma, Gagan Kaushal, Alok Bhushan, Michael Bukrinsky, Priya Tyagi
Department of Medicine Faculty Papers
HIV infection remains a major global health challenge due to its complex pathogenesis and lifelong persistence in people living with HIV (PLWH). A central barrier to eradication is the virus's ability to establish long-lived latent reservoirs in different tissues, including the central nervous system (CNS), where it evades immune clearance and antiretroviral therapy (ART). These reservoirs, seeded early during infection, fuel viral rebound if ART is interrupted, requiring lifelong treatment. In the CNS, HIV persists despite systemic viral suppression because of limited ART penetration across the blood-brain barrier (BBB), and infection of long-lived cells such as microglia and perivascular macrophages. …
Bridging The Intention-Implementation Divide In Generative Ai Adoption: An Integrated Model Of Psychological, Behavioral And Social Drivers, Mohamed Walid Mohamed Lotfy Abdallah
Bridging The Intention-Implementation Divide In Generative Ai Adoption: An Integrated Model Of Psychological, Behavioral And Social Drivers, Mohamed Walid Mohamed Lotfy Abdallah
USF Tampa Graduate Theses and Dissertations
This dissertation examines the gap between professionals’ intentions to use Generative Artificial Intelligence (AI) and their actual adoption behavior in workplace settings. Although Generative AI offers substantial potential to improve efficiency and performance, concerns about control, misuse and organizational risk have led to inconsistencies between intended and enacted use. Motivated by this misalignment, the study investigates the psychological, behavioral and social mechanisms that shape the intention-implementation divide. Drawing on an integrated framework combining the Theory of Planned Behavior and the Technology Acceptance Model, alongside personality traits, the research conceptualizes adoption as a phase-specific process involving evaluative, motivational and volitional components. …
Coordinated Stimulation Of Axon Regenerative And Neurodegenerative Transcriptional Programs By Atf4 Following Optic Nerve Injury, Preethi Somasundaram, Madeline M Farley, Melissa A Rudy, Katya Sigal, Andoni I Asencor, David G Stefanoff, Malay Shah, Puneetha Goli, Jenny Heo, Shufang Wang, Nicholas M Tran, Trent A Watkins
Coordinated Stimulation Of Axon Regenerative And Neurodegenerative Transcriptional Programs By Atf4 Following Optic Nerve Injury, Preethi Somasundaram, Madeline M Farley, Melissa A Rudy, Katya Sigal, Andoni I Asencor, David G Stefanoff, Malay Shah, Puneetha Goli, Jenny Heo, Shufang Wang, Nicholas M Tran, Trent A Watkins
Faculty, Staff and Students Publications
Stress signaling is important for determining the fates of neurons following axonal insults. Previously, we showed that the stress-responsive kinase PERK contributes to injury-induced neurodegeneration (Larhammar et al., 2017). Here, we show that PERK acts primarily through activating transcription factor-4 (ATF4) to stimulate not only pro-apoptotic but also pro-regenerative responses following optic nerve damage. Using conditional knockout mice, we find an extensive PERK/ATF4-dependent transcriptional response that includes canonical ATF4 target genes and modest contributions by C/EBP Homologous Protein (CHOP). Overlap with c-Jun-dependent transcription suggests interplay with a parallel stress pathway that orchestrates regenerative and apoptotic responses. Accordingly, neuronal knockout of …
Balancing Education And Health Among Rural Schoolchildren During Prolonged Heat Wave In The Philippines, Elias Olapane
Balancing Education And Health Among Rural Schoolchildren During Prolonged Heat Wave In The Philippines, Elias Olapane
Kesmas
Intensifying heat waves disrupt learning environments in the Philippines, particularly in rural areas where schools often lack adaptive infrastructure. Many rural classrooms are built with heat-retaining materials, such as concrete, which trap excessive heat, leading to indoor temperatures exceeding safe comfort levels. These conditions lead to dehydration, fatigue, and reduced cognitive function, directly impairing students’ focus and academic performance. Schoolchildren are particularly vulnerable due to their developing thermoregulatory systems, higher metabolic demands, and potential preexisting health conditions. These risks are further amplified in rural communities with limited access to cooling, healthcare, and adaptive resources. These challenges require practical, context-specific interventions. …
Laser Interstitial Thermal Therapy And Adjuvant Pembrolizumab In Recurrent High-Grade Astrocytoma: A Phase 1/Randomized Phase 2b Trial, Jian L Campian, Omar H Butt, Yifei Xu, Jingxia Liu, William A Leidig, Tanner Johanns, George Ansstas, Alice Y Zhou, Sangami Pugazenthi, Jiayi Huang, Milan G Chheda, Albert H Kim, Eric C Leuthardt, Et Al.
Laser Interstitial Thermal Therapy And Adjuvant Pembrolizumab In Recurrent High-Grade Astrocytoma: A Phase 1/Randomized Phase 2b Trial, Jian L Campian, Omar H Butt, Yifei Xu, Jingxia Liu, William A Leidig, Tanner Johanns, George Ansstas, Alice Y Zhou, Sangami Pugazenthi, Jiayi Huang, Milan G Chheda, Albert H Kim, Eric C Leuthardt, Et Al.
2020-Current year OA Pubs
Immune checkpoint inhibitors (ICIs) show minimal efficacy in recurrent high-grade astrocytoma (rHGA). Laser interstitial thermal therapy (LITT), a minimally invasive cytoreductive approach, may prime rHGA for ICI response. A phase 1/randomized phase 2b trial (ClinicalTrials.gov: NCT02311582 ) was designed to test pembrolizumab in combination with LITT in patients with rHGA. Nine patients were enrolled in the phase I dose-escalation lead-in study. No dose-limiting toxicities were observed and 200 mg of pembrolizumab every three weeks was determined as the recommended phase 2 dose. The phase 2b study was initially designed to randomize (up to 45) patients 1:1 to either LITT followed …
Recognizing Structural And Social Determinants Of Health In The Diagnosis And Care Of Dementia, Shana D Stites, Sharnita Midgett, Nisha Patel, Kimberly Halberstadter, Rosalie Schumann, Marissa L Streitz, Yidan Shi, John C Morris, Jason Flatt, Crystal M Glover, Dawn Mechanic-Hamilton
Recognizing Structural And Social Determinants Of Health In The Diagnosis And Care Of Dementia, Shana D Stites, Sharnita Midgett, Nisha Patel, Kimberly Halberstadter, Rosalie Schumann, Marissa L Streitz, Yidan Shi, John C Morris, Jason Flatt, Crystal M Glover, Dawn Mechanic-Hamilton
2020-Current year OA Pubs
Structural and social determinants of health are environmental conditions that affect individuals' health and functioning across the life course. These determinants are salient factors at the apex of individual psychology, community variables, and larger sociological factors, exerting prominent effects on individuals' wellbeing. The National Institute on Aging seeks to understand their influence on aging and Alzheimer's disease. We propose that the benefits of doing so may reach beyond knowledge of disease mechanisms - it may also improve clinical outcomes. We describe efforts introducing structural and social determinants of health data into the national network of Alzheimer's disease research centers. We …
Adjunctive Hyperbaric Oxygen Therapy For Chronic Diabetic Foot Ulcer Unresponsive To Standard Care: A Case Report, Ismail Ismail, Sukriyadi Adi, Sitti Rahmatia, Agustan Agustan
Adjunctive Hyperbaric Oxygen Therapy For Chronic Diabetic Foot Ulcer Unresponsive To Standard Care: A Case Report, Ismail Ismail, Sukriyadi Adi, Sitti Rahmatia, Agustan Agustan
BioMedicine
Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus and are often challenging to treat, particularly in patients who fail to respond to standard wound care. Adjunctive therapies such as hyperbaric oxygen therapy (HBOT) have shown potential in promoting wound healing in chronic cases.
Case Presentation: A 66-year-old male with a 10-year history of type 2 diabetes mellitus presented with a chronic, non-healing DFU on the right foot. Despite oral antibiotic therapy and conventional wound management, the ulcer demonstrated progressive necrosis, persistent infection, and tissue exposure. Wound culture identified Klebsiella oxytoca. After targeted antibiotic treatment, the patient …
Neurosurgical Management Of Pineal Lesions: Insights From A Single-Center Study Of 27 Cases, David Montesinos Contreras, Walter Stummer, Maryam Khaleghi Ghadiri
Neurosurgical Management Of Pineal Lesions: Insights From A Single-Center Study Of 27 Cases, David Montesinos Contreras, Walter Stummer, Maryam Khaleghi Ghadiri
BioMedicine
Introduction: Pineal lesions are rare and surgically challenging due to their deep location, histological diversity, and potential malignancy. The complexity of the pineal region anatomy and the diverse pathological spectrum contribute to the lack of standardized treatment strategies, making appropriate management controversial. Aim: This study aimed to evaluate the surgical outcomes of patients with pineal tumors or cysts and to assess the impact of different surgical approaches, particularly the extent of resection, on progression-free survival. Methods: We conducted a retrospective analysis of 27 patients treated for pineal tumors or cysts at our institution between 2010 and 2020. Data regarding clinical …
A Glimpse Into The Impact Of Physical Activity On Linear Growth In Children And Adolescents Through Activity Restrictions Accompanying The Covid-19 Outbreak, Yi-Chun Lin, Wen-Ling Liao, Chung-Hsing Wang, Fuu-Jen Tsai
A Glimpse Into The Impact Of Physical Activity On Linear Growth In Children And Adolescents Through Activity Restrictions Accompanying The Covid-19 Outbreak, Yi-Chun Lin, Wen-Ling Liao, Chung-Hsing Wang, Fuu-Jen Tsai
BioMedicine
Background: Linear growth in children and adolescents, a key health indicator, is influenced by various factors, including physical activity (PA). The COVID-19 lockdown in Taiwan created a unique opportunity to examine the effect of PA restrictions on growth.
Methods: This retrospective cohort study was conducted at two hospitals in central Taiwan. The study included 72 children and adolescents (26 males, 46 females) who attended a growth clinic. Height and weight measurements were recorded in three stages: pre-lockdown, during lockdown, and post-lockdown. Growth rates were compared across stages using paired t-tests.
Results: The average growth rate was lowest during lockdown (0.0181 …
Assessing The Capabilities Of Ai-Based Large Language Models (Ai-Llms) In Interpreting Histopathological Slides And Scientific Figures: Performance Evaluation Study, Khanisyah Erza Gumilar, Grace Ariani, Priangga A. Wiratama, Rimbun Rimbun, Tri H. Yuliawati, Hong Chen, Ibrahim H. Ibrahim
Assessing The Capabilities Of Ai-Based Large Language Models (Ai-Llms) In Interpreting Histopathological Slides And Scientific Figures: Performance Evaluation Study, Khanisyah Erza Gumilar, Grace Ariani, Priangga A. Wiratama, Rimbun Rimbun, Tri H. Yuliawati, Hong Chen, Ibrahim H. Ibrahim
BioMedicine
Background: Integrating artificial intelligence-based large language models (AI-LLMs) into medical and other scientific domains is increasingly recognized as a tool to support complex tasks, such as interpreting histopathology slides and scientific figures. AI-LLMs can simplify these processes by providing clearer explanations. By improving accessibility and comprehension, AI-LLMs can significantly assist healthcare professionals in diagnosing and therapy determination. Students and the public also find it easier to understand complex scientific concepts and images.
Objectives: This study explores the capability of AI-LLMs in interpreting histopathological slides and scientific images. This study aims to evaluate the performance of AI-LLMs in supporting diagnostics and …
Decyl Caffeate Inhibits The Proliferation Of Human Triple-Negative Breast Cancer Cells, Che-Yi Chao, Woei-Cheang Shyu, Chih-Lung Lin, En-Pei Isabel Chiang, Yueh-Hsiung Kuo, Feng-Yao Tang
Decyl Caffeate Inhibits The Proliferation Of Human Triple-Negative Breast Cancer Cells, Che-Yi Chao, Woei-Cheang Shyu, Chih-Lung Lin, En-Pei Isabel Chiang, Yueh-Hsiung Kuo, Feng-Yao Tang
BioMedicine
Background: Over recent decades, considerable attention has been directed toward the discovery of novel compounds capable of targeting survival-related signaling networks as therapeutic candidates for triple-negative breast cancer (TNBC). Central to TNBC pathobiology are the Akt/mTOR and MAPK/ERK signaling axes, both contribute to tumor progression and therapeutic resistance. Caffeic acid (CA), a naturally derived phenolic compound with anti-inflammatory activity, has previously been investigated for its anti-cancer potential. Purpose: In the present study, we explored the therapeutic value of newly synthesized CA derivatives in TNBC models using both cellular and animal-based systems. Methods: The anti-tumor efficacy of these CA derivatives was …
The Association Between The Gnb3 Rs5443 C/C Genotype And Obesity Phenotypes In Taiwanese Individuals, Ling-Yi Xiao, Zi-Lun Lai, Yang-Di Su, Szu-Yun Wang, Nia-Jia Zheng, Po- Ren Hsueh
The Association Between The Gnb3 Rs5443 C/C Genotype And Obesity Phenotypes In Taiwanese Individuals, Ling-Yi Xiao, Zi-Lun Lai, Yang-Di Su, Szu-Yun Wang, Nia-Jia Zheng, Po- Ren Hsueh
BioMedicine
Background: The prevalence of obesity has increased significantly over the
years, and its health concerns cannot be underestimated. Obesity not only
causes potential mobility limitations in daily life but also increases the risk of
developing cardiovascular diseases, diabetes, cancer and other health
conditions. While an imbalanced diet and lack of exercise are well-known
causes of obesity, genetic patterns also influence its development. Although the GNB3 gene is known to be involved in lipid metabolism and fat cell
differentiation, studies have shown inconsistent associations between a
common single nucleotide polymorphism of GNB3 (c.825C>T, rs5443) and
obesity across different populations. Therefore, …
Chinese Herbal Medicine Treatment And The Association With Long-Term Major Adverse Cardiac Events In Patients With Chronic Kidney Disease: A Propensity-Score Matched Cohort Study, Yuan-Ching Liao, Mei-Yao Wu, Cheng-Li Lin, Chiz-Tzung Chang, Peter Mayer, Hung-Rong Yen
Chinese Herbal Medicine Treatment And The Association With Long-Term Major Adverse Cardiac Events In Patients With Chronic Kidney Disease: A Propensity-Score Matched Cohort Study, Yuan-Ching Liao, Mei-Yao Wu, Cheng-Li Lin, Chiz-Tzung Chang, Peter Mayer, Hung-Rong Yen
BioMedicine
Background: Cardiovascular disease (CVD) represents the leading cause of
mortality among idividuals with chronic kidney disease (CKD). While Chinese herbal
medicine (CHM) is commonly used by CKD patients in Taiwan, the impact of CHM
use on cardiovascular outcomes in this population remains insufficiently understood.
Aims: This study aimed to evaluate the association between CHM use and the long-
term risk of major adverse cardiac events (MACEs) in patients with CKD.
Methods: Data were obtained from the Taiwan National Health Insurance Research Database to identify patients aged over 20 years with newly diagnosed CKD. A 1:1 propensity score matching was performed …
Increased Dairy Product Consumption Is Associated With Shorter Telomere Length In Buccal Cells Among Normotensive Adults, Hsin-Hwa Tsai, Yang-Di Su, Zi-Lun Lai, Chia-Yu Lin, Shu-Fan Lin, Hsiu-Ching Hsu, Wen-Yuan Lin, Po-Ren Hsueh
Increased Dairy Product Consumption Is Associated With Shorter Telomere Length In Buccal Cells Among Normotensive Adults, Hsin-Hwa Tsai, Yang-Di Su, Zi-Lun Lai, Chia-Yu Lin, Shu-Fan Lin, Hsiu-Ching Hsu, Wen-Yuan Lin, Po-Ren Hsueh
BioMedicine
Background: Telomere length (TL) is a biomarker of biological aging and a predictor of age-related diseases. Dietary patterns, including dairy consumption, may influence telomere dynamics, but the evidence remains limited, particularly in Asian populations. This study investigates the association between dairy consumption and relative telomere length (RTL) in Taiwanese adults, with results analyzed by hypertension status.
Methods: A cross-sectional survey was conducted among 259 adults in Taipei, Taiwan. RTL was measured using quantitative PCR from buccal cells. Dietary intake was assessed through self-reported questionnaires, with a focus on dairy frequency and fat content. Multiple linear regression models were used to …
Scrambling The Classroom And Gamification In Pharmacology For Nurses: Engaging The Learner, Laura Nugteren, Julie De Haan
Scrambling The Classroom And Gamification In Pharmacology For Nurses: Engaging The Learner, Laura Nugteren, Julie De Haan
Day of Scholarship
After several years of lower scores on the ATI proctored Pharmacology exam, the nursing department separated the pathophysiology/pharmacology course into two separate courses. Goals for the new pharmacology course included (1) focus on what entry-level nursing graduates would need to know about pharmacology to improve end-of-program testing scores and (2) engagement of the learner by scrambling the classroom and utilizing gamification for application practice. Intentional course design focused on inclusive and active teaching strategies including: consistent weekly rhythm; highly structured preparation activities (Hogan & Sathy, 2022); scrambled classroom integrating chunked lecture to explain complex concepts with active learning and gamification …
Advancing Practice-Ready Communication: Utilizing Virtual Simulation To Apply Ipass And Isbarr, Bethany Gerdin, Laura Nugteren
Advancing Practice-Ready Communication: Utilizing Virtual Simulation To Apply Ipass And Isbarr, Bethany Gerdin, Laura Nugteren
Day of Scholarship
Nursing students have limited opportunity to practice interdisciplinary communication or handoff in the clinical setting. The purpose of this learning experience is for students to differentiate between and practice appropriate use of IPASS and ISBARR in a standardized patient during an interactive patient experience using virtual simulation (VSIM), which mimics the complex reality of a clinical patient scenario. Students complete a medical-surgical VSIM independently and then participate in a faculty-guided small group activity where they discuss rationale and prioritization for interventions completed throughout the VSIM. The small group collaboratively prepares an ISBARR communication between the nurse and provider for a …
Supporting Evidence-Based Responses To Emotional Needs In Emphysema (Serene): Protocol For A Randomized, Open-Label Mechanistic Trial Comparing Coping Skills Training And Disease-Specific Education For Depressive Symptoms Conducted In United States Health Systems, Joanna L. Hart, Daniel Carter, Chloe Hinton, James Grilli, Lily A. Brown, Nora Brier, Yingying Lu, Casey Whitman, Michael O. Harhay, Michael Sims, Carmen Alvarez, Lisa R. Miller-Matero, C. Virginia O'Hayer
Supporting Evidence-Based Responses To Emotional Needs In Emphysema (Serene): Protocol For A Randomized, Open-Label Mechanistic Trial Comparing Coping Skills Training And Disease-Specific Education For Depressive Symptoms Conducted In United States Health Systems, Joanna L. Hart, Daniel Carter, Chloe Hinton, James Grilli, Lily A. Brown, Nora Brier, Yingying Lu, Casey Whitman, Michael O. Harhay, Michael Sims, Carmen Alvarez, Lisa R. Miller-Matero, C. Virginia O'Hayer
Department of Psychiatry and Human Behavior Faculty Papers
BACKGROUND: Depressive symptoms and anxiety are highly prevalent among people with chronic obstructive pulmonary disease (COPD), strongly associated with poor outcomes, and rarely recognized or treated. Integrating families into interventions may amplify supportive care treatment effects and overcome common challenges, yet this strategy is understudied. The Supporting Evidence-based Responses to Emotional Needs in Emphysema (SERENE) trial's main objective is to identify the mechanisms through which a family-partnered Coping Skills Training (CST) reduces depressive symptoms among patients with COPD, testing five putative mechanisms: family relationship quality, patient and caregiver self-efficacy, patient loneliness, and caregiver psychological distress.
METHODS: SERENE will enroll 375 …
Determination Of Cortisol Concentrations Using Different Biomarkers In Dairy Goats During Pregnancy, Fatma Mi̇ra Güven, Erkan Pehli̇van
Determination Of Cortisol Concentrations Using Different Biomarkers In Dairy Goats During Pregnancy, Fatma Mi̇ra Güven, Erkan Pehli̇van
Turkish Journal of Veterinary & Animal Sciences
Pregnancy is considered one of the most physiologically stressful periods in mammals. In the present study, serum and hair cortisol concentrations were measured in nine female Akkeçi goats, including five primiparous (1.5 years old) and four multiparous (3.5 years old), to evaluate chronic stress during pregnancy. Hair samples were collected in October, November, and December following the introduction of bucks to the herd and within the first 12 h postpartum (corresponding to the 1st, 2nd, 3rd, and 7th sampling times). Hair samples were not collected in January, February, or March (the 4th, 5th, and 6th sampling times) due to insufficient …
Effects Of Zinc-Reinforced Clinoptilolite On Hematological Parameters, Igg Levels, And Enzyme Histochemistry In Fattening Lambs, İhsan Kisadere, Muhi̇tti̇n Zengi̇n, Özkan Demi̇rbaş, Mehmet Faruk Aydin
Effects Of Zinc-Reinforced Clinoptilolite On Hematological Parameters, Igg Levels, And Enzyme Histochemistry In Fattening Lambs, İhsan Kisadere, Muhi̇tti̇n Zengi̇n, Özkan Demi̇rbaş, Mehmet Faruk Aydin
Turkish Journal of Veterinary & Animal Sciences
The study aimed to determine the effects of zinc-reinforced clinoptilolite supplementation to the diet on selected hematological parameters, serum immunoglobulin G (IgG) concentrations, and enzyme histochemical characteristics in fattening lambs. For this purpose, 40 healthy male lambs were randomly allocated into five equal groups: control (C; n = 8), natural clinoptilolite (NC; n = 8), zinc (ZN; n = 8), natural clinoptilolite plus zinc (NCZN; n = 8), and zinc-reinforced clinoptilolite (ZNRC; n = 8). All animals were housed in individual pens, and the supplementation period continued for 42 days. Blood samples were collected before the trial (day 0) and …
Cover And Contents
Turkish Journal of Veterinary & Animal Sciences
No abstract provided.
Comparison Of The Mars And Xgboost Algorithms For Predicting Body Weight In Kalahari Red Goats, Louis Thobela Tyasi, Cem Tirink, Kwena Mokoena, Hasan Önder, Uğur Şen, Demet Çanga Boğa, Tolga Tolun, İsmai̇l Gök, Yüksel Aksoy, Lütfi̇ Bayyurt, Ömer Faruk Yilmaz
Comparison Of The Mars And Xgboost Algorithms For Predicting Body Weight In Kalahari Red Goats, Louis Thobela Tyasi, Cem Tirink, Kwena Mokoena, Hasan Önder, Uğur Şen, Demet Çanga Boğa, Tolga Tolun, İsmai̇l Gök, Yüksel Aksoy, Lütfi̇ Bayyurt, Ömer Faruk Yilmaz
Turkish Journal of Veterinary & Animal Sciences
Estimating goat body weight from morphometric traits is essential for growth monitoring, health management, and welfare. Accurate weight informs nutrition, clinical interventions, and mating decisions. In this study, the MARS and XGBoost algorithms were used to estimate the live weight of Kalahari Red goats based on body measurements. A dataset containing body length (BL), birth type (single, twin, or triplet), withers height (WH), rump height (RH), and heart girth (HG) information for 200 goats was used in the training and testing of the models. The performances of the models were evaluated with the goodness-of-fit criteria. XGBoost showed a performance of …
Hatchability And Nestling Viability In An Extremely Short-Beaked Pigeon Breed, Türker Savaş, Hakan Erdem, Cemi̇l Tölü
Hatchability And Nestling Viability In An Extremely Short-Beaked Pigeon Breed, Türker Savaş, Hakan Erdem, Cemi̇l Tölü
Turkish Journal of Veterinary & Animal Sciences
The selection of hobby animals for breeding by enthusiasts is often based on aesthetic considerations, which can have a negative impact on the animals’ biology. Furthermore, “extreme traits” that deviate from ancestral norms, such as short beaks in pigeons, can be detrimental to the animal’s welfare. Beaks perform many essential functions, such as facilitating feed intake and eggshell breaking. The present study investigates possible hatching problems and the nestling viability of short-beak pigeons through a study of the breeding records of Mısıri (short beak), Baska (medium beak), and Turkish Dönek (normal beak) pigeons, as well as data from one breeding …
Osteopathic Manipulative Treatment Vs. Standard Therapy In The Management Of Acute Neck And Low Back Pain In The Emergency Department, Steven M Hochman, Katherine Vlasica, Alexis Lapietra, Bhargavi K Patel, Christine Ju, Nicholas J Mota, Scott Wilder
Osteopathic Manipulative Treatment Vs. Standard Therapy In The Management Of Acute Neck And Low Back Pain In The Emergency Department, Steven M Hochman, Katherine Vlasica, Alexis Lapietra, Bhargavi K Patel, Christine Ju, Nicholas J Mota, Scott Wilder
Faculty, Staff and Student Publications
Context: Acute neck and low back pain are common emergency department (ED) presentations, generally treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Osteopathic manipulative treatment (OMT) is a hands-on treatment modality utilized to treat a variety of musculoskeletal conditions.
Objectives: We sought to evaluate the relative efficacies and side effects of hands-on OMT vs. one dose of oral ibuprofen, in the treatment of adult patients presenting with acute neck or back pain.
Methods: We conducted a prospective randomized controlled trial at a high-volume urban ED. Adult patients with acute neck or low back pain were randomized to 5 min of OMT or …
Response To "Pulmonary Hypertension As A Determinant Of In-Hospital Mortality In Copd: Insights And Methodological Considerations", Trishna Parikh, Saad Afzal Khan, Adishwar Rao, Bela Patel, Bindu Akkanti
Response To "Pulmonary Hypertension As A Determinant Of In-Hospital Mortality In Copd: Insights And Methodological Considerations", Trishna Parikh, Saad Afzal Khan, Adishwar Rao, Bela Patel, Bindu Akkanti
Faculty, Staff and Student Publications
No abstract provided.
Encapsulation Of Cannabidiol In Chitosan-Stabilized Argan Oil Nanoemulsion As A Potential Dermal Drug Delivery System For Psoriasis Treatment, Yousra Mdarhri, Vinicius De-Monte-Vidal, Camila De-Almeida-Perez-Pimenta, Selene Cuello-Rodríguez, Ahmed Touhami, Fakhita Touhami, Mohamed Chabbi, Victoria Díaz-Tomé
Encapsulation Of Cannabidiol In Chitosan-Stabilized Argan Oil Nanoemulsion As A Potential Dermal Drug Delivery System For Psoriasis Treatment, Yousra Mdarhri, Vinicius De-Monte-Vidal, Camila De-Almeida-Perez-Pimenta, Selene Cuello-Rodríguez, Ahmed Touhami, Fakhita Touhami, Mohamed Chabbi, Victoria Díaz-Tomé
Physics & Astronomy Faculty Publications
Background: Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis sativa, exhibits therapeutic potential for various conditions, including inflammation, pain, and skin disorders, making it a promising candidate for the topical treatment of psoriasis. However, its poor water solubility and instability limit its therapeutic efficacy. This study focuses on the development and characterization of CBD-loaded nanoemulsions using argan oil as the lipid phase, with and without a chitosan coating, which serves as a stabilizing and functional biopolymer. Methods: Nanoemulsions (NE) and chitosan-stabilized nanoemulsions (CS-NE), both without CBD (serving as controls), and CBD-loaded variants (CBD-NE and CBD-CS-NE) were prepared and characterized for …
Social Roles And Emotional Distress Are Associated With Successful Aging In Adult Childhood Cancer Survivors, Samah Hayek, Kimberly A Miller, Michael E Roth, Michelle A T Hildebrandt, David R Freyer, Joel Milam
Social Roles And Emotional Distress Are Associated With Successful Aging In Adult Childhood Cancer Survivors, Samah Hayek, Kimberly A Miller, Michael E Roth, Michelle A T Hildebrandt, David R Freyer, Joel Milam
Faculty, Staff and Student Publications
Childhood cancer survivors (CCS) face complex long-term health consequences resulting from intensive treatments that may impact their aging trajectory. This study assessed the associations between social role attainment, emotional distress, and indicators of successful aging (SA) among adult CCS, considering treatment intensity. SA, is a multidimensional concept encompassing physical, cognitive, and psychosocial well-being, provides a framework for understanding and optimizing outcomes in this population. This cross-sectional study utilized data from Project Forward, a cohort, of 1,248 adult CCS diagnosed between 1996 and 2010. Participants were identified through the Los Angeles County Cancer Surveillance Program and completed a comprehensive self-report survey …
Respiratory Syncytial Virus Co-Detection With Other Respiratory Viruses Is Not Significantly Associated With Worse Clinical Outcomes Among Children Aged <2 Years: New Vaccine Surveillance Network, 2016-2020, Justin Z Amarin, Ariana P Toepfer, Andrew J Spieker, Haya Hayek, Tess Stopczynski, Yasmeen Z Qwaider, Laura S Stewart, James D Chappell, Mary Allen Staat, Elizabeth P Schlaudecker, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Marian G Michaels, John V Williams, Rangaraj Selvarangan, Christopher J Harrison, Leila C Sahni, Vasanthi Avadhanula, Meredith L Mcmorrow, Heidi L Moline, Natasha B Halasa
Respiratory Syncytial Virus Co-Detection With Other Respiratory Viruses Is Not Significantly Associated With Worse Clinical Outcomes Among Children Aged <2 Years: New Vaccine Surveillance Network, 2016-2020, Justin Z Amarin, Ariana P Toepfer, Andrew J Spieker, Haya Hayek, Tess Stopczynski, Yasmeen Z Qwaider, Laura S Stewart, James D Chappell, Mary Allen Staat, Elizabeth P Schlaudecker, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Marian G Michaels, John V Williams, Rangaraj Selvarangan, Christopher J Harrison, Leila C Sahni, Vasanthi Avadhanula, Meredith L Mcmorrow, Heidi L Moline, Natasha B Halasa
Faculty, Staff and Students Publications
Background: Risk factors for severe respiratory syncytial virus (RSV) illness include early infancy, premature birth, and underlying medical conditions. However, the clinical significance of respiratory viral co-detection is unclear. We compared the clinical outcomes of young children with RSV-only detection and those with RSV viral co-detection.
Methods: We conducted active, population-based surveillance of children with medically attended fever or respiratory symptoms at 7 US medical centers (1 December 2016-31 March 2020). Demographic and clinical data were collected through parental interviews and chart abstractions. Nasal swabs, with or without throat swabs, were systematically tested for RSV and 6 other common respiratory …
Staff Education On Phq-9 To Improve Depression Screening And Patient Outcomes, Ahmad Ghandour
Staff Education On Phq-9 To Improve Depression Screening And Patient Outcomes, Ahmad Ghandour
Walden Dissertations and Doctoral Studies
Depression is a prevalent mental health condition that significantly affects patient quality of life and healthcare utilization. Clinical guidelines recommend routine depression screening in adults when appropriate systems for follow-up and treatment are in place. The Patient Health Questionnaire-9 (PHQ-9) is a validated instrument used to identify depressive symptoms and assess severity in outpatient settings. Despite national recommendations supporting routine depression screening using the PHQ-9, a significant practice gap remains in the consistent administration, accurate scoring, and proper documentation of the tool in outpatient. Research indicated that variability in screening practices is frequently associated with inadequate staff training and lack …
Expansion Of A Self-Guided Curriculum And Validation Of A Self-Assessment Tool For Ocular Examination Skills, Maria Lee, Irene Pak, Aryan Chaychian, Isabell Kassaye, Adam Alyafaie, Neeti Parikh, Madeline Yung
Expansion Of A Self-Guided Curriculum And Validation Of A Self-Assessment Tool For Ocular Examination Skills, Maria Lee, Irene Pak, Aryan Chaychian, Isabell Kassaye, Adam Alyafaie, Neeti Parikh, Madeline Yung
Journal of Academic Ophthalmology
Background: Public interest in vision health is growing, yet ophthalmology remains underemphasized in medical education due to time constraints associated with in-person instruction.
Purpose: To demonstrate effectiveness of self-guided e-learning modules for ocular examination skills and to determine whether self-assessments can reliably assess medical student proficiency in these skills.
Methods: Medical students at a single institution participated in a skills workshop. Group 1 completed self-guided modules for visual acuity, confrontational visual field testing, pupil examination, and extraocular motility evaluation. Group 2 completed a self-guided module for the slit lamp anterior segment examination. Afterward, each student completed a …
Ophthalmology Exposure For Medical Students In Institutions Without A Home Ophthalmology Department: A Review Of The Literature, Rayna Marshall, Sara A. Khan, Meghan Berkenstock
Ophthalmology Exposure For Medical Students In Institutions Without A Home Ophthalmology Department: A Review Of The Literature, Rayna Marshall, Sara A. Khan, Meghan Berkenstock
Journal of Academic Ophthalmology
Background: Matching into an ophthalmology residency program has become increasingly competitive, with a 66% overall match rate reported by the San Francisco Match in 2024. Early exposure to ophthalmology is critical for students to develop an interest in the field, build robust research experiences, and find mentors to create a competitive ophthalmology residency application. These experiences can often be difficult to acquire at institutions that lack an ophthalmology department. Such institutions face unique challenges in providing mentorship and exposure in this medical specialty, underscoring the need for innovative solutions to support interested students.
Purpose: To assess ways a …