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Articles 9151 - 9180 of 326454
Full-Text Articles in Entire DC Network
Evidence To Support Certification In Online Nursing Teaching Excellence: A Systematic Review, Ellen Vorbeck, Louisa Krueger, Ellen Johnson
Evidence To Support Certification In Online Nursing Teaching Excellence: A Systematic Review, Ellen Vorbeck, Louisa Krueger, Ellen Johnson
Internet Journal of Allied Health Sciences and Practice
Abstract
A systematic review of the literature following PRISMA© (2020) was conducted to determine the evidence within nursing and higher education literature to support certification in online teaching and to determine the value of additional certification for nurse educators in higher education nursing programs. Data from CINAHL, ERIC, EBSCO, COCHRANE, AND PUBMED databases were collected following inclusion and exclusion criteria. An independent review by two authors was conducted with twenty-seven articles and one report identified. Bias was examined, followed by deductive analysis, which identified common themes and subthemes within the research. The results suggest that high-quality online courses require instructors …
Agreement Of Chatgpt With Clinical Practice Guidelines For Knee Osteoarthritis Treatment, Alessandra N. Garcia, Brian Neville, Bradley Myers, Lori Leineke, Karlyn Green
Agreement Of Chatgpt With Clinical Practice Guidelines For Knee Osteoarthritis Treatment, Alessandra N. Garcia, Brian Neville, Bradley Myers, Lori Leineke, Karlyn Green
Internet Journal of Allied Health Sciences and Practice
Purpose: This cross-sectional study evaluated whether Chat Generative Pre-Trained Transformer (ChatGPT) GPT-3.5 and GPT-4O provide treatment information consistent with high-quality clinical practice guidelines (CPGs) for knee osteoarthritis (OA). Methods: High-quality CPGs published in the past decade were identified via PubMed and PEDro, with the search updated on November 11, 2024. Guidelines were appraised using the AGREE II tool. GPT-3.5 and GPT-4O were queried with common treatment-related questions, and their responses were compared to CPG recommendations. Two independent reviewers conducted a thematic content analysis of GPT-3.5 and GPT-4O responses using a deductive–inductive codebook, iteratively refined through consensus, to identify major themes/subthemes, …
National Physical Therapy Examination Scores From 2023 And 2024 Cohorts In The United States, Richard Cahanin, James W. Farris, Tara Andrews, Preston Warren, Jennifer Patterson, Shawn Drake, Barry Dale
National Physical Therapy Examination Scores From 2023 And 2024 Cohorts In The United States, Richard Cahanin, James W. Farris, Tara Andrews, Preston Warren, Jennifer Patterson, Shawn Drake, Barry Dale
Internet Journal of Allied Health Sciences and Practice
Purpose: This study aimed to determine which student academic performance variables within physical therapy education programs most strongly predicted NPTE scores. Methods: A prospective, multi-institutional cohort study with 228 doctoral physical therapy students representing the 2023 and 2024 cohorts was conducted. Hierarchical multiple linear regression and receiver operating characteristic analyses were used to evaluate research hypotheses. Results: No significant difference in NPTE scores between the 2023 and 2024 cohorts was found (p = .936). A streamlined model identified 2-year DPT GPA (p < .001), total PEAT score (p = .004), and total GRE score (p = .046) as the most significant …
Health Professional Students' Experiences With Gender-Identity Inclusive Content In The Classroom And Supervised Clinical Learning, Perry Xinyi Zhang, Aria Grabowski, Olivia S. Anderson
Health Professional Students' Experiences With Gender-Identity Inclusive Content In The Classroom And Supervised Clinical Learning, Perry Xinyi Zhang, Aria Grabowski, Olivia S. Anderson
Internet Journal of Allied Health Sciences and Practice
Purpose: Gender-identity diverse populations have unique healthcare needs, but they experience stigmatization leading to negative health outcomes. Healthcare professionals have reported obstacles to delivering affirming care to gender-identity diverse patients due to limited training. We assessed how health profession students encounter gender-identity content and how students’ perceived preparedness to provide care for gender-identity diverse populations. Methods: A survey distributed to students enrolled in health professional programs at a large mid-western university included close-ended questions about exposure to gender-identity diverse curricular content in didactic and supervised clinical settings and perceived preparedness to work with gender-identity diverse populations. Open-ended questions asked what …
A Mixed Method Approach To Assessing The Feasibility Of Implementing The Ottawa Paramedic Physical Abilities Test (Tm) In The Australian Context, Samantha Sheridan, Rodney Pope, Renee S. Macphee, Alexander Macquarrie, Steven Fischer, Gavin Buzza, Hannah Stack, Lyndal Bolton, Jacob Grevell, Christopher Tony Sheridan, Jacinta Buckman, Russell Rayner
A Mixed Method Approach To Assessing The Feasibility Of Implementing The Ottawa Paramedic Physical Abilities Test (Tm) In The Australian Context, Samantha Sheridan, Rodney Pope, Renee S. Macphee, Alexander Macquarrie, Steven Fischer, Gavin Buzza, Hannah Stack, Lyndal Bolton, Jacob Grevell, Christopher Tony Sheridan, Jacinta Buckman, Russell Rayner
Internet Journal of Allied Health Sciences and Practice
Introduction: There is a need for evidence-based pre-employment physical fitness test standards in paramedic organisations. This study aimed to assess the feasibility of implementing an existing, international, standardised pre-employment paramedic physical capacity test, the Ottawa Paramedic Physical Abilities Test (OPPATTM), in the Australian context. Methods: In this mixed-method feasibility study, 12 undergraduate paramedicine students completed two generic predictive tests - a three-minute step test (3MST20) and a grip strength test - and two physical employment tests: the Ottawa Paramedic Physical Abilities Test (OPPATTM) and the New South Wales Ambulance Test (NSWAT) – and a …
Does Relevant Work Experience Influence Academic Success? A Retrospective Study Of Doctor Of Physical Therapy Students, Nicole Tombers, Kate Corrigan, Rylee Kwiatkowski, Gwinna Remillard, Morgan Scanlon, Maddy Soderberg
Does Relevant Work Experience Influence Academic Success? A Retrospective Study Of Doctor Of Physical Therapy Students, Nicole Tombers, Kate Corrigan, Rylee Kwiatkowski, Gwinna Remillard, Morgan Scanlon, Maddy Soderberg
Internet Journal of Allied Health Sciences and Practice
Purpose: Relevant work experience is a factor considered in holistic admissions practices of many health profession education programs. The benefits of observation hours on student career choice and subsequent academic success have been explored. Many programs additionally consider paid work experience as a factor in admissions decisions; however the influence of relevant work experience on academic outcomes is unknown. This study examined relationships between paid physical therapy related work experience and performance in a DPT program. Method: Data from 945 applicants resulting in 191 matriculants to a single DPT program were included. Employment history for all applicants was coded as …
The Effect Of Debriefing Following A Computer-Based Low-Fidelity Simulation On The Self-Efficacy Of Health Professions Students: A Randomized Cross-Over Control Study, Matthew Mills, Enrico Gandolfi, Richard E. Ferdig, Kimberly Peer
The Effect Of Debriefing Following A Computer-Based Low-Fidelity Simulation On The Self-Efficacy Of Health Professions Students: A Randomized Cross-Over Control Study, Matthew Mills, Enrico Gandolfi, Richard E. Ferdig, Kimberly Peer
Internet Journal of Allied Health Sciences and Practice
Purpose: Simulations have been increasingly used in health science education to supplement clinical experience. There is evidence of the benefits of high-fidelity simulation (HFS) with debriefing, but HFS is costly and time-intensive to administer. Low-fidelity simulation (LFS) has been proposed as an alternative that is easier to scale and more cost-effective; however, the evidence surrounding its impact on students is mixed, possibly because debriefing is frequently omitted in LFS. Methods: A randomized experimental mixed methods cross-over control study was performed to evaluate the impact of a structured debriefing session following an interactive computer-based low-fidelity simulation on the self-efficacy and anxiety …
What Numbers Don't Tell Us: Can Sociodemographic Factors Identify Grit, Resilience, And Imposter Phenomenon In Hybrid Doctor Of Physical Therapy Students?, Benton Lindaman, Marlena Calo, Brandon Ness, James Smoliga, Moyo B. Tillery, Suzanne Trotter, Liana Wooten, Shefali Christopher
What Numbers Don't Tell Us: Can Sociodemographic Factors Identify Grit, Resilience, And Imposter Phenomenon In Hybrid Doctor Of Physical Therapy Students?, Benton Lindaman, Marlena Calo, Brandon Ness, James Smoliga, Moyo B. Tillery, Suzanne Trotter, Liana Wooten, Shefali Christopher
Internet Journal of Allied Health Sciences and Practice
Purpose: To determine whether routinely collected sociodemographic admissions criteria (e.g., first-generation status, race, government assistance, youth employment) could serve as proxies for non-cognitive traits such as grit, resilience, and imposter phenomenon in hybrid Doctor of Physical Therapy (DPT) students. Method: A descriptive, cross-sectional survey was conducted among first-year students (N=100) across three accelerated, hybrid DPT programs. Students completed validated instruments measuring grit (Grit-O), general resilience (Brief Resilience Scale), academic resilience (Academic Resilience Scale), and imposter phenomenon (Clance Imposter Phenomenon Scale) during their first semester. Sociodemographic data were obtained from admissions applications. Between-group comparisons were analyzed using independent t-tests and …
Acquisition Of Basic Clinical Skills Among Japanese Novice Rehabilitation Therapists: A Retrospective Study, Kenta Fujimura, Hiroaki Sakurai, Soichiro Koyama, Kenji Kawakami, Kazuya Takeda, Takuma Ii, Shota Suzumura, Shigeo Tanabe, Yoshikiyo Kanada
Acquisition Of Basic Clinical Skills Among Japanese Novice Rehabilitation Therapists: A Retrospective Study, Kenta Fujimura, Hiroaki Sakurai, Soichiro Koyama, Kenji Kawakami, Kazuya Takeda, Takuma Ii, Shota Suzumura, Shigeo Tanabe, Yoshikiyo Kanada
Internet Journal of Allied Health Sciences and Practice
Purpose: This study examined the relationship between basic clinical skills and clinical experience among novice rehabilitation therapists in Japan. Methods: Twenty-one novice rehabilitation therapists who joined a general hospital and underwent annual practical examinations during each of their three years of clinical experience were included. This retrospective longitudinal single-center study followed the same novice therapists throughout the study period. The practical examination was based on the Objective Structured Clinical Examination (OSCE) and included exercises for joint range of motion (ROM), muscle strengthening (MS), getting up (Getting Up), standing up and sitting down (Standing/Sitting), and transferring from a wheelchair to a …
The Effect Of A Mindfulness-Based Program On Musculoskeletal Pain And Function, Christine Conroy, Kent E. Irwin, Paige Dougherty, Teresa Elliott-Burke
The Effect Of A Mindfulness-Based Program On Musculoskeletal Pain And Function, Christine Conroy, Kent E. Irwin, Paige Dougherty, Teresa Elliott-Burke
Internet Journal of Allied Health Sciences and Practice
Purpose: Mindfulness-based Stress Reduction (MBSR) is a structured therapeutic tool that was developed in the 1980s by Kabat-Zinn and colleagues. Mindfulness-based interventions (MBIs) have been developed based on the fundamental principles of MBSR and are an emerging area of research. These programs are used to decrease pain levels and kinesiophobia in patients with chronic disease and pain. The purpose of this case study is to describe the effects of MBIs on function and pain for a middle-aged patient, two-month post-proximal humerus fracture. Method: A 53-year-old woman presented status post closed fracture of the proximal right humerus resulting from a …
Institutional Prestige And Prerequisite Performance As Predictors Of Academic Success In Doctor Of Physical Therapy Programs: A Pilot Retrospective Cohort Study, Margaret Wicinski, Tamala Marcin
Institutional Prestige And Prerequisite Performance As Predictors Of Academic Success In Doctor Of Physical Therapy Programs: A Pilot Retrospective Cohort Study, Margaret Wicinski, Tamala Marcin
Internet Journal of Allied Health Sciences and Practice
Purpose: This pilot study examined relationships between Carnegie Classification levels of undergraduate institutions, prerequisite anatomy and physiology (AP) performance, and academic success in Doctor of Physical Therapy (DPT) education. Methods: This retrospective cohort study analyzed records from 83 students who graduated from a single DPT program in 2019. Data included Carnegie Classifications of prerequisite institutions, undergraduate anatomy and physiology grade point average (UGPA AP 1&2 GPA), first-term pathophysiology course grade (Patho GPA), and Doctor of Physical Therapy program grade point average (DPT GPA). Statistical analyses included Spearman rank order correlation (rs) and Kruskal-Wallis tests with effect size calculations. Power analysis …
Effectiveness Of Core Strengthening In The Treatment Of Chronic Low Back Pain: A Literature Review, Khalid G. Attia
Effectiveness Of Core Strengthening In The Treatment Of Chronic Low Back Pain: A Literature Review, Khalid G. Attia
Internet Journal of Allied Health Sciences and Practice
Purpose: Chronic low back pain (CLBP) is one of the leading causes of disability in the world. High levels of functional impairment, mental stress, and socioeconomic burdens usually accompany it. With the shift in paradigm to a non-pharmacological approach to management, core strengthening exercises have assumed a central role in the conservative approach to CLBP rehabilitation. Moreover, there is also the inclusion of complementary practices of yoga and Pilates, as well as new technologies in digital health, which has expanded the field of therapy The goals of this literature review are to review evidence of the effectiveness of core stabilization, …
Face And Content Validity Of A Survey Tool To Measure Perceived Barriers And Facilitators To Diabetes Management In Rural Veterans: Perspectives Of Registered Dietitians, Jameson Tade, Mary Shotwell, Ronette Lategan-Potgieter, Marty R. Jacobson
Face And Content Validity Of A Survey Tool To Measure Perceived Barriers And Facilitators To Diabetes Management In Rural Veterans: Perspectives Of Registered Dietitians, Jameson Tade, Mary Shotwell, Ronette Lategan-Potgieter, Marty R. Jacobson
Internet Journal of Allied Health Sciences and Practice
Purpose: Type 2 diabetes mellitus (T2DM) is a major health challenge in the United States, affecting over 36 million Americans exceeding $105 billion annually in treatment-related costs.1,2 Type 2 diabetes affects some populations more than others, including rural and veteran populations.1,3 Registered dietitians (RDs) are an integral part of the diabetes management team, but limited literature is available to identify perceived barriers to T2DM management in military veterans who preside in rural areas. The purpose of this study was to explore face and content validity of a survey tool distributed to Veterans Health Administration (VHA) dietitians in a …
Exploring Hydration Strategies: A Preliminary Comparison Of Fluid Administration Methods In Collegiate Football Players, Emily E. Lodge, Gillian Romanchok, Isabella M. Farmer, Kimberly Schwabenbauer, Rich Patterson
Exploring Hydration Strategies: A Preliminary Comparison Of Fluid Administration Methods In Collegiate Football Players, Emily E. Lodge, Gillian Romanchok, Isabella M. Farmer, Kimberly Schwabenbauer, Rich Patterson
Internet Journal of Allied Health Sciences and Practice
Introduction: Maintaining optimal hydration is critical for athletic performance and preventing heat-related illness, particularly among football players who face elevated risk due to heavy protective equipment and intense physical demands. As core body temperature and heart rate increases, physiological strain causes are directly correlated with the severity of body water deficit. Dehydration levels exceeding 2% of body weight significantly impair both aerobic performance capacity and cognitive ability. Purpose: Therefore, the purpose of this research is to investigate whether fluid consumption among collegiate football players differs based on administration methods (self-administration versus athletic trainer administration) during practice sessions. Methods: Twenty male …
The Phases Of Variation In Physiotherapy Management Of Organophosphate Poisoning Patients: A Case Series, Manish P. Shukla, Sachin A. Chaudhary, Hemant Deshpande, Nikita Gupta
The Phases Of Variation In Physiotherapy Management Of Organophosphate Poisoning Patients: A Case Series, Manish P. Shukla, Sachin A. Chaudhary, Hemant Deshpande, Nikita Gupta
Internet Journal of Allied Health Sciences and Practice
Purpose: Organophosphate (OP) poisoning presents a significant challenge in healthcare, with varying severities requiring adaptive management strategies. This case series examines the physiotherapy management of three patients with different levels of OP poisoning severity: mild, moderate and severe. The study highlights the crucial role of physiotherapy in the multidisciplinary care of OP poisoning patients and demonstrates the need for phase-specific interventions tailored to individual patient needs. Method: The severe case required prolonged mechanical ventilation and intensive care, with physiotherapy progressing from passive techniques to active mobilization over 15 days. The moderate case showed faster recovery, allowing for earlier initiation of …
Firearm Violence Prevention: Analysis Of Physical Therapy Political Action Committee Financial Contributions And Congressional Voting, Kim D. Dao, Edward P. Mulligan, Michael Siegel, Liana Wooten
Firearm Violence Prevention: Analysis Of Physical Therapy Political Action Committee Financial Contributions And Congressional Voting, Kim D. Dao, Edward P. Mulligan, Michael Siegel, Liana Wooten
Internet Journal of Allied Health Sciences and Practice
Purpose. The American Physical Therapy Association (APTA) declared firearm violence a public health crisis in 2019. This investigation aimed to understand relationships between the amount of APTA political action committee (PTPAC) donations received by a federal candidate and (1) their voting records on FV prevention legislation; and (2) their voting records on other APTA-supported legislation. Methods. Data pertaining to the identification and amount of PTPAC donations to federal Congressional candidates during the 2020 and 2022 election cycles were gathered from the public resource, Open Secrets. Public voting records were compiled on firearm and other APTA-supported legislation. Results. 222 candidates received …
The Sympathetic And Clinical Effects Of Dry Needling To The Thoracolumbar Junction Multifidi: A Randomized Controlled Trial, Nicole Clark, Cheryl J. Hill, Joshua Cleland, Thomas Massie, Shane Koppenhaver
The Sympathetic And Clinical Effects Of Dry Needling To The Thoracolumbar Junction Multifidi: A Randomized Controlled Trial, Nicole Clark, Cheryl J. Hill, Joshua Cleland, Thomas Massie, Shane Koppenhaver
Internet Journal of Allied Health Sciences and Practice
Purpose: The primary aim of this study was to investigate the neurophysiological effects of dry needling (DN) to the thoracolumbar junction multifidi when compared with a placebo. The secondary objective was to determine if there is a relationship between post-treatment pain and disability and the magnitude of sympathetic nervous system activity. Methods: Participants were eligible if they had low back pain, limited flexibility in at least one hamstring, and had not previously received DN. Participants completed the Numeric Pain Rating Scale and Oswestry Disability Index, underwent pressure pain threshold testing, and were randomized to a DN or sham …
Cognitive And Emotional Conflict Control Among Children Affected By Parental Hiv/Aids In China, Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li Ph.D., Junfeng Zhao
Cognitive And Emotional Conflict Control Among Children Affected By Parental Hiv/Aids In China, Huihui Wang, Juan Liu, Danfeng Wen, Wan Zhao, Xiaoming Li Ph.D., Junfeng Zhao
Faculty Publications
Background: Children affected by parental HIV/AIDS constitute a particularly vulnerable population, often facing heightened risks in psychosocial adaptation due to family disruption, social stigma, and resource deprivation. However, the characteristics of their executive functions, particularly the core component of conflict monitoring, remain unclear.
Methods: The present study compared the performance of children affected by parental HIV/AIDS (n=32) to a control group (n=32) on a cognitive conflict and emotional conflict face-word Stroop task.
Results: The results of the cognitive Stroop task demonstrated that both groups showed better performance in congruent stimuli compared to incongruent stimuli (86.20% vs.67.30%; 568.43ms vs.586.04ms). In the …
Victimization, Health, And Help Seeking In North Dakota: How Interpersonal Violence Shapes Physical And Mental Health, Tahmid Hassan Jeeshan
Victimization, Health, And Help Seeking In North Dakota: How Interpersonal Violence Shapes Physical And Mental Health, Tahmid Hassan Jeeshan
Graduate Research Achievement Day Posters
Interpersonal violence extends beyond physical assault to include psychological and/or emotional abuse that can produce substantial physical and mental health consequences. This study examines how multiple forms of interpersonal violence relate to health outcomes among North Dakotan women, focusing on differences between rural and non rural residents. We compare victimization patterns, physical and mental health status, and treatment seeking behaviors. We anticipate that rural victims will report more severe or chronic victimization yet face reduced access to and use of healthcare and victim services. By jointly considering violence type, rural versus non-rural status, health outcomes, and treatment seeking, this project …
Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta
Impediments To Transforming The Healthcare Delivery System: Shifting The Paradigm From Provider Centric To Patient Centric, Elizabeth A. Regan, Manasa Devi Chinta
Faculty Publications
Introduction:
Stated aims for digital healthcare transformation frequently cite goals for better coordinated patient-centric systems. However, despite advances in medical science, digital technologies, health policies, and billions of dollars invested over the past 25 years, most healthcare providers are far from fully realizing the demonstrated benefits of today's digital technologies for improving patient care. Sharing information across healthcare systems remains challenging. Problems with fragmentation, quality, inequities, and rising costs of care delivery persist. A recent study of 1,026 U.S. hospital systems found that only 15.8 percent achieved a digital maturity level needed to provide digitally enabled healthcare services to better …
Integrated Multi-Omic Analysis Reveals Novel Subtype-Specific Regulatory Interactions In Pediatric B-Cell Acute Lymphoblastic Leukemia., Irina Pushel, Zachary S. Clark, Lisa A. Lansdon, Byunggil Yoo, Michaella J. Rekowski, Nicole Wood, Michael P. Washburn, Midhat S. Farooqi
Integrated Multi-Omic Analysis Reveals Novel Subtype-Specific Regulatory Interactions In Pediatric B-Cell Acute Lymphoblastic Leukemia., Irina Pushel, Zachary S. Clark, Lisa A. Lansdon, Byunggil Yoo, Michaella J. Rekowski, Nicole Wood, Michael P. Washburn, Midhat S. Farooqi
Manuscripts, Articles, Book Chapters and Other Papers
Background/Objectives: Molecular subtyping of pediatric B-cell acute lymphoblastic leukemia (B-ALL) has improved patient outcomes through stratification and selection of targeted therapies. Despite extensive genomic and transcriptomic profiling of this cancer, few studies to date have characterized the proteomic landscape, although proteins are the direct targets of many therapeutic agents. Methods: In this study, we demonstrate the utility of multi-omic integration of global transcriptomic, proteomic, and phosphoproteomic profiles of samples from patients diagnosed with either of two B-ALL subtypes-Ph-like (BCR::ABL1-like) and ETV6::RUNX1. Through individual and multi-omic analysis, we recapitulate known transcriptomic findings and identify novel subtype-specific …
Muscular Fitness Levels Of U.S. Children And Adolescents, Daniel J. Mcdonough, Yong Gao, Lynda B. Ransdell, Haichun Sun
Muscular Fitness Levels Of U.S. Children And Adolescents, Daniel J. Mcdonough, Yong Gao, Lynda B. Ransdell, Haichun Sun
International Journal of Physical Activity and Health
Purpose: To describe muscular fitness (MF) levels and percentile benchmarks among U.S. children and adolescents aged 6–15 years old across sociodemographic, physiological, and behavioral subgroups. Methods: Data were from the 2012 NHANES National Youth Fitness Survey (NNYFS). Four strength tests consisting of the plank, knee extension, modified pull-up, and handgrip, were analyzed by age, sex, race/ethnicity, income, BMI category, cardiorespiratory fitness (CRF), and physical activity (PA) among 1,234 participants (51% male) using SAS SURVEY procedures. Results: Mean ± SEM scores were 69.6 ± 1.8 s (plank), 56.6 ± 4.2 lb (left) and 59.2 ± 4.3 lb (right) knee extension, 5.5 …
Vlx-1005, But Not Argatroban, Prevents Itam-Mediated Platelet Activation And Heparin-Induced Thrombocytopenia, Adriana Yamaguchi, Victoria Putzbach, Reheman Adili, Sophia Lazar, Livia Stanger, Devin Gilmore, David J. Maloney, Steven E. Mckenzie, James V. Michael, Michael Holinstat
Vlx-1005, But Not Argatroban, Prevents Itam-Mediated Platelet Activation And Heparin-Induced Thrombocytopenia, Adriana Yamaguchi, Victoria Putzbach, Reheman Adili, Sophia Lazar, Livia Stanger, Devin Gilmore, David J. Maloney, Steven E. Mckenzie, James V. Michael, Michael Holinstat
Cardeza Foundation for Hematologic Research
Heparin-induced thrombocytopenia (HIT) is an immune prothrombotic disorder characterized by the binding of platelet-activating immunoglobulin G antibodies to platelet factor 4/heparin. In platelets, this leads to cross-linking of the immunoreceptor tyrosine-based activation motif (ITAM)-bearing receptor FcγRIIa, platelet activation, and thrombocytopenia, which in combination with extensive thrombin generation significantly increases the risk of thrombosis. Our laboratory has previously demonstrated that 12-lipoxygenase (12-LOX), an oxygenase primarily expressed in platelets, plays a critical role in platelet activation through FcγRIIa. In this study, we aimed to determine the effectiveness of VLX-1005, a potent and selective inhibitor of 12-LOX, alone or in combination with argatroban, …
Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai
Post-Traumatic Stress Disorder And Risk Of All-Cause And Cause-Specific Mortality: A Nationwide Population And Sibling-Controlled Cohort Study In Taiwan, Chih-Wei Hsu, Yang-Chieh Brian Chen, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Edward Chia-Cheng Lai
Children’s Nutrition Research Center Staff Publications
Aims: Post-traumatic stress disorder (PTSD) may shorten life expectancy, but evidence for Asian populations and cause-specific mortality remains limited. The aim of this study is to investigate the association between PTSD and mortality risk in an Asian population.
Methods: We used Taiwan's National Health Insurance Research Database (2000-2022) to assemble a cohort of 28,777 individuals with incident PTSD and 115,108 age- and sex-matched unexposed individuals, plus a sibling cohort of 13,305 affected patients and 22,030 unaffected siblings. Cox models estimated adjusted hazard ratios (AHRs) for all-cause, unnatural-cause (suicide and accidents) and natural-cause mortality, with progressive adjustment for sociodemographic factors, comorbidity …
Single Ventricle Physiology May Not Preclude Cardiac Repair In The Setting Of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, Amir M Khan, D Michael Mcmullan, Anthony Johnson, Charles S Cox, Matthew T Harting, Damien J Lapar
Single Ventricle Physiology May Not Preclude Cardiac Repair In The Setting Of Congenital Diaphragmatic Hernia, Kylie I Holden, Michael C Scott, Ashley H Ebanks, Amir M Khan, D Michael Mcmullan, Anthony Johnson, Charles S Cox, Matthew T Harting, Damien J Lapar
The Brown Foundation: Institute of Molecular Medicine
Objective: Management for congenital heart disease (CHD) with congenital diaphragmatic hernia (CDH), particularly in single ventricle physiology, is challenging, with limited studies showing poor outcomes. This investigation evaluated outcomes for these complex patients.
Methods: This retrospective cohort study (2007-2022) from the CDH Study Group analyzed mortality in patients with CDH and single ventricle physiology, using standard statistical methods and Cox regression for estimation.
Results: A total of 9,261 CDH patients were identified, including 1,886 with CDH + CHD and 131 with single ventricle physiology. The median gestational age was 38 weeks and birthweight was 2.8 kg. Of 131 patients, 34 …
Influence Of Body Composition On The Efficacy Of Nivolumab Plus Ipilimumab For Metastatic Clear Cell Renal Cell Carcinoma, Kabir Grewal, Maria Julia Moura Nascimento Santos, Pankaj Kumar Chauhan, Kai Yu, Nizar M Tannir, Sagar S Mukhida, Neha Venkatesh, Amishi Y Shah, Amado J Zurita, Andrew C Johns, Matthew T Campbell, Sangeeta Goswami, Jianjun Gao, Eric Jonasch, Jennifer L Mcquade, Omar Alhalabi, Pavlos Msaouel, Andrew W Hahn
Influence Of Body Composition On The Efficacy Of Nivolumab Plus Ipilimumab For Metastatic Clear Cell Renal Cell Carcinoma, Kabir Grewal, Maria Julia Moura Nascimento Santos, Pankaj Kumar Chauhan, Kai Yu, Nizar M Tannir, Sagar S Mukhida, Neha Venkatesh, Amishi Y Shah, Amado J Zurita, Andrew C Johns, Matthew T Campbell, Sangeeta Goswami, Jianjun Gao, Eric Jonasch, Jennifer L Mcquade, Omar Alhalabi, Pavlos Msaouel, Andrew W Hahn
Faculty, Staff and Student Publications
Background: Immune checkpoint inhibitor therapy (ICI) with nivolumab+ipilimumab is a first-line (1L) standard for metastatic clear cell renal cell carcinoma (ccRCC), yet outcomes remain heterogeneous. Increasing evidence suggests that host factors influence the tumor microenvironment and response to ICI. Although higher body mass index (BMI) has been associated with improved outcomes in several malignancies, BMI is an imprecise surrogate for underlying adipose and muscle compartments. We evaluated the association between body composition and outcomes with 1L nivolumab+ipilimumab in metastatic ccRCC.
Methods: We retrospectively analyzed patients with mccRCC treated with 1L nivolumab+ipilimumab at MD Anderson Cancer Center between June 2015 and …
Tongue Reduction For Pediatric Obstructive Sleep Apnea: A Systematic Review., Adrian Williamson, Rohit Nallani, Jason R. Brown
Tongue Reduction For Pediatric Obstructive Sleep Apnea: A Systematic Review., Adrian Williamson, Rohit Nallani, Jason R. Brown
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE: Obstructive sleep apnea (OSA) is a prevalent pediatric disorder that, if untreated, can result in substantial developmental and health consequences. Tongue reduction procedures, such as midline posterior glossectomy (MPG), are increasingly used to address tongue base obstruction. This systematic review evaluates the effectiveness and safety of tongue reduction procedures for pediatric OSA.
DATA SOURCES: Embase, PubMed, and Web of Science databases were queried for studies from inception to September 20, 2023.
REVIEW METHODS: Studies reporting on outcomes of pediatric patients (≤21 years) undergoing tongue reduction surgery for OSA were included.
RESULTS: From 477 abstracts, 9 studies met the inclusion …
Prevalence And Characteristics Of Workplace Violence Towards Healthcare Workers In Primary Healthcare Settings In Muscat, Oman, Manar Al Sanaa Ali Al Zeedi, Bishara Hamed Al Maamari, Khadija Saleh Alghammari, Aisha Rashid Al Mufarrji, Nahid Saif Al Hasni, Rahma Yaqoob Al Shuhaimi
Prevalence And Characteristics Of Workplace Violence Towards Healthcare Workers In Primary Healthcare Settings In Muscat, Oman, Manar Al Sanaa Ali Al Zeedi, Bishara Hamed Al Maamari, Khadija Saleh Alghammari, Aisha Rashid Al Mufarrji, Nahid Saif Al Hasni, Rahma Yaqoob Al Shuhaimi
Sultan Qaboos University Medical Journal
Objectives: Workplace violence (WPV) is a growing occupational health concern, with healthcare workers (HCWs) particularly at risk. While high rates of WPV towards HCWs have been reported in emergency and psychiatry settings in Oman, little is known about its prevalence in primary care. This study aimed to assess the prevalence and characteristics of WPV towards HCWs in primary care settings in Muscat, Oman. Methods: This cross-sectional study was conducted between November and December 2024 in Muscat's primary health centres using the validated Workplace Violence in the Health Sector Country Questionnaire. Descriptive statistics and inferential analyses (Chi-square and logistic regression) were …
Single-Layer Spherical (Sls) Vs Single-Layer (Sl) Woven Endobridge (Web) Device In The Treatment Of Narrow-Neck Intracranial Aneurysms: A Propensity Score-Matched Analysis, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Nimer Adeeb, Basel Musmar, Muhammed Amir Essibayi, Motaz Daraghma, Mahmoud Dibas, Nicole M Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D Rabinov, Julian Maingard, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Robert M Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Eytan Raz, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I Levy, Neil Haranhalli, David Altschul, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I Tjoumakaris, Hugo H Cuellar-Saenz, Pascal M Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B Patel, Max Wintermark, Adam A Dmytriw
Single-Layer Spherical (Sls) Vs Single-Layer (Sl) Woven Endobridge (Web) Device In The Treatment Of Narrow-Neck Intracranial Aneurysms: A Propensity Score-Matched Analysis, Hamza Adel Salim, Vivek Yedavalli, Fathi Milhem, Nimer Adeeb, Basel Musmar, Muhammed Amir Essibayi, Motaz Daraghma, Mahmoud Dibas, Nicole M Cancelliere, Jose Danilo Bengzon Diestro, Oktay Algin, Sherief Ghozy, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Joseph Carnevale, Guillaume Saliou, Panagiotis Mastorakos, Kareem El Naamani, Eimad Shotar, Markus Möhlenbruch, Michael Kral, Charlotte Chung, Mohamed M Salem, Ivan Lylyk, Paul M Foreman, Hamza Shaikh, Vedran Župančić, Muhammad U Hafeez, Joshua Catapano, Muhammad Waqas, Muhammet Arslan, Onur Ergun, James D Rabinov, Julian Maingard, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Robert M Starke, Ameer Hassan, Mark Ogilvie, Anh Nguyen, Jesse Jones, Waleed Brinjikji, Marie T Nawka, Marios Psychogios, Christian Ulfert, Bryan Pukenas, Jan-Karl Burkhardt, Thien Huynh, Juan Carlos Martinez-Gutierrez, Sunil A Sheth, Diana Slawski, Rabih Tawk, Benjamin Pulli, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Eytan Raz, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Elad I Levy, Neil Haranhalli, David Altschul, Andrew F Ducruet, Felipe C Albuquerque, Robert W Regenhardt, Christopher J Stapleton, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Stavropoula I Tjoumakaris, Hugo H Cuellar-Saenz, Pascal M Jabbour, Frédéric Clarençon, Nicola Limbucci, Vitor Mendes Pereira, Aman B Patel, Max Wintermark, Adam A Dmytriw
Faculty, Staff and Student Publications
Data on the use of Woven EndoBridge (WEB) devices in the treatment of narrow-neck intracranial aneurysms (NNA) are limited. We compared the efficacy and safety of single-layer (SL) and single-layer spherical (SLS) WEB devices in treating NNA. We conducted a multicenter retrospective analysis of adult patients with NNA (neck ≤ 4 mm and width-to-neck ratio ≥ 2) treated with SL or SLS WEB devices between January 2011 and December 2022. Patients with fusiform or blister aneurysms, adjunctive treatments, or devices other than SL or SLS were excluded. Propensity score matching was used to adjust for confounding variables. Outcomes included procedural …
Pregnancy, Cancer, And Radiation-A Modern Refresher, Kelly Kisling, Sandra M Meyers, Rebecca Milman, Susan Richardson, Christina Chapman, Justine Dupere, Grace Eliason, Suzanne Evans, Titania Juang, Young Lee, Jeffrey Masten, Julia Maues, Rachel Newman, Mike Silosky, Catherine Song, Catheryn Yashar, Sara Thrower
Pregnancy, Cancer, And Radiation-A Modern Refresher, Kelly Kisling, Sandra M Meyers, Rebecca Milman, Susan Richardson, Christina Chapman, Justine Dupere, Grace Eliason, Suzanne Evans, Titania Juang, Young Lee, Jeffrey Masten, Julia Maues, Rachel Newman, Mike Silosky, Catherine Song, Catheryn Yashar, Sara Thrower
Faculty, Staff and Student Publications
Cancer occurs in ∼1 per 1000 pregnancies; thousands of patients may require radiation procedures for diagnosis and treatment each year in the United States alone. This rare but high-risk scenario, coupled with fear of radiation, has created ambiguity in the ideal management of pregnant patients. Without a comprehensive guide for the use of radiation in imaging and treatment for pregnant cancer patients, it is difficult for providers to offer optimal patient-centered care without introducing disparities. The goal of this paper is to provide guidance on the use of radiation for screening, diagnosis, staging, and treatment of cancer, while highlighting gaps …