Digital Commons Network^™

Antiobesity, Antidiabetic, And Antioxidant Activities Of Selected Rubia Species (Rubiaceae) And Lc–Ms/Ms-Based Chemical Profiling ​, Semi̇h Bulut, Ahmet Kahraman, Ayşenur Işik, Mustafa Abdullah Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rubia species (Rubiaceae) are recognized as medicinal and industrial plants exhibiting diverse biological activities. This study was conducted to evaluate the antioxidant, antidiabetic, and antiobesity potential of extracts prepared from Rubia davisiana Ehrend. (an endemic species), R. peregrina L., and R. rotundifolia Banks & Sol., which grow naturally in Türkiye.

Materials and methods: The antioxidant activity of 80% ethanol extracts prepared from the aerial parts was evaluated using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing power, metal chelating capacity, and total antioxidant capacity assays. Inhibition assays for α-glucosidase and α-amylase were performed to evaluate antidiabetic activity, …

L-Theanine Attenuates Alcl3-Induced Cognitive Dysfunction And Neurotoxicity In Rats: A Behavioral And Biochemical Study, Muhammet Oğuzhan Dönmez, Azi̇ze Şener, Şeyda Karaman Ersoy, Mahdi̇ Marzi̇, Göksel Şener

Turkish Journal of Medical Sciences

Background/aim: The effects of L-theanine (LTN), a natural compound found in tea leaves, on biochemical parameters and cognitive functions were investigated in an aluminum chloride (AlCl3)-induced Alzheimer’s disease-like experimental model.

Materials and methods: A total of 32 male Wistar rats were allocated into four groups: control, AlCl3-induced AD-like group, LTN-treated AD-like group, and donepezil-treated AD-like group. Donepezil was used as a reference drug. For the induction of AlCl3- induced neurotoxicity, AlCl3 was administered by gavage at a dose of 25 mg/kg/day during the 1st week and 150 mg/kg/day for the subsequent 3 weeks. LTN was administered orally at a dose …

Therapeutic Potential Of Nasal Kisspeptin-54 For Reducing Α-Synuclein Accumulation And Restoring Hippocampal Synaptic Plasticity In A 6-Hydroxydopamine-Induced Rat Model Of Parkinson’S Disease ​, Ayşegül Gemi̇ci̇ Si̇nen, Emre Savran, Okyanus Bora Güleç, Osman Si̇nen, Nari̇n Deri̇n

Turkish Journal of Medical Sciences

Background/aim: Parkinson’s disease (PD) is characterized by progressive degeneration of dopaminergic neurons and pathological aggregation of α-synuclein (α-syn), leading to significant motor and cognitive impairments. Kisspeptin-54 (KP-54), a neuropeptide primarily involved in reproductive regulation, has recently been implicated in neurorestorative processes, with emerging evidence suggesting beneficial effects on locomotor activity and cognitive function. However, its therapeutic potential in PD has not yet been fully investigated. This study aimed to evaluate the therapeutic efficacy of chronic nasal KP-54 administration in a 6-hydroxydopamine (6-OHDA) rat model of PD, focusing on motor and cognitive outcomes, hippocampal synaptic plasticity, and α-syn pathology.

Materials and …

Boric Acid Enhances The Antitumor Effects Of Paclitaxel By Modulating Apoptosis, Autophagy-Related Protein Expression, And Proinflammatory Cytokine Expression In Ovcar-3 Ovarian Cancer Cells ​, Nazmi̇ye Bi̇tgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Meli̇ke Akbulut, Arzu Yay

Turkish Journal of Medical Sciences

Background/aim: Ovarian cancer is the eighth most prevalent malignancy among women globally and ranks third among gynecological cancers in terms of incidence. The limited efficacy of standard chemotherapy, primarily due to intrinsic drug resistance and high recurrence rates, highlights the urgent need for novel therapeutic strategies that are both effective and selectively cytotoxic.

Materials and methods: This study aimed to investigate the combined effects of boric acid (BA), a biologically active boron compound with emerging antitumor potential, and paclitaxel (PTX), a conventional chemotherapeutic agent, on cell viability, cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling in the chemoresistant …

Exploratory Evaluation Of Mir-146, Inflammatory Biomarkers, And Subjective Cognitive Symptoms In Chronic Migraine ​, Hale Gök Dağidir, Duygu Bandirmali, Merve Hi̇lal Ceren Akgör, Doğa Vuralli, Meltem Yalinay, Güvem Gümüş Akay, Hayrunni̇sa Bolay

Turkish Journal of Medical Sciences

Background/aim: Chronic migraine (CM) is a disabling neurological disorder associated with substantial impairment of quality of life. Increasing evidence suggests that inflammatory and epigenetic mechanisms may contribute to migraine pathophysiology. miR- 146, a microRNA involved in the TLR-4/NFkb pathway, is known to regulate proinflammatory signaling, whereas HMGB1 activates inflammatory pathways through TLR2 and TLR4 receptors. IL-17 is another proinflammatory cytokine implicated in both inflammation and cognitive processes. In this research, our aim was to investigate the relationship between serum HMGB1, IL-17, and miR-146 levels and migraine-related subjective cognitive symptoms in patients with CM.

Materials and methods: Serum samples were collected …

Erratum To “Effects Of Colchicine On Sah-Induced Vascular Damage In An Experimental Subarachnoid Hemorrhage Model’’ [Turkish Journal Of Medical Sciences 56 (2) 2026 597-607] ​, Emi̇ne Demi̇r, Cumaali̇ Demi̇rtaş, Cansu Sönmez, Eray Meti̇n Güler, Sarper Kocaoğlu, Hakan Beyaztaş, Eyüp Çeti̇n

Turkish Journal of Medical Sciences

The original article can be accessed at https://doi.org/10.55730/1300-0144.6192.

Background/aim: Subarachnoid haemorrhage (SAH) is a severe cerebrovascular condition with high morbidity and mortality. Inflammation and oxidative stress are key factors in its pathophysiology, particularly in secondary vascular injury. This study aimed to evaluate the effects of colchicine on vascular integrity and biochemical markers following SAH in an experimental rat model.

Materials and methods: Eighteen female Sprague-Dawley rats were divided into three groups: Control (no SAH), SAH (induced without treatment), and SAH + Colchicine (1 mg/kg intraperitoneally at 1 h and 24 h). SAH was induced by autologous blood injection into …

Erratum To “Hla Allele And Haplotype Diversity In Central Anatolia: A Comparative Analysis Of Donors And Transplant Candidates Across Six Hla Loci (Hla-A, Hla-B, Hla-C, Hla-Drb1, Hla-Dqb1, And Hla-Dpb1)’’ [Turkish Journal Of Medical Sciences 56 (3) 2026 817-827] ​, Emel Yantir, Eren Gündüz

Turkish Journal of Medical Sciences

The original article can be accessed at https://doi.org/10.55730/1300-0144.6216.

In Article No. 56-3-22, entitled “HLA Allele and Haplotype Diversity in Central Anatolia: A Comparative Analysis of Donors and Transplant Candidates across Six HLA Loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, and HLA-DPB1)”, an error was identified in the DOI of the Aperta link provided in the Supplementary Materials section, as the final digit of the DOI was inadvertently omitted.
The correct and complete version of the link is provided below on a separate page.
https://aperta.ulakbim.gov.tr/records/287387

Direct Pars Repair Techniques For Lumbar Spondylolysis: A Comparative Literature Review ​, Kami̇l C. Kose, Moustafa Ibrahim, Ni̇cholas D. Haden, John Afolayan, Hanny Anwar

Turkish Journal of Medical Sciences

Background/aim: Lumbar spondylolysis, a pars interarticularis defect affecting approximately 3%–6% of the general population, presents a significant clinical challenge in young adults and athletes. When conservative management fails, direct pars repair offers an attractive alternative to spinal fusion by preserving segmental motion and reducing the risk of adjacent segment degeneration. This narrative review compares seven principal direct pars repair techniques—Buck’s technique, Scott’s wiring method, Morscher’s hook-screw system, pedicle screw-based constructs, the V-rod/U-rod (Gillet technique), the smiley face rod construct, and the dualstability construct (DSC)—evaluating their biomechanical properties, clinical outcomes, fusion rates, and complication profiles.

Materials and methods: A narrative literature …

Posttraumatic Stress In Newly Diagnosed Epilepsy: Associations With Early Maladaptive Schemas, Anxiety, And Quality Of Life In A 6-Month Prospective Study ​, Mehmet Öztürk, Pinar Öztürk, Fügen Sönmez Çeti̇nkaya, İlker Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: Epilepsy is a chronic neurological disorder that significantly affects psychosocial functioning, self-perception, and quality of life. Emerging evidence suggests that posttraumatic stress (PTS) symptoms may be more prevalent in individuals with epilepsy than previously recognized, particularly following seizure-related experiences perceived as traumatic. The aim of this study was to evaluate short- and long-term PTS levels in individuals with newly diagnosed epilepsy and examine their associations with anxiety, depression, early maladaptive schemas, and quality of life.

Materials and methods: In this prospective study, 31 individuals with newly diagnosed epilepsy were enrolled. Participants completed a sociodemographic data form, the Post-Traumatic Stress …

Cervical Conjoined Nerve Root Anomalies: Prevalence And Impact On Posterior Cervical Surgery, Ahmet Eren Seçen, Ayfer Aslan, Musa Onur Özbakir, Uğur Kemal Gündüz, Ali̇ Dalgiç

Turkish Journal of Medical Sciences

Background/aim: Anomalous nerve roots (ANRs) are well described in the lumbosacral spine but are rarely reported in the cervical region. The aim of this study was to evaluate the incidence, clinical characteristics, and surgical outcomes of cervical ANRs, with particular emphasis on conjoined nerve roots, in a single-center clinical series.

Materials and methods: A retrospective analysis was conducted of patients who underwent posterior cervical discectomy for cervical disc herniation at our institution between 2010 and 2025. A total of 113 posterior cervical procedures were performed, and seven patients were found to have surgically confirmed cervical ANRs. For these patients, demographic …

Preserved Inflammatory Homeostasis During Emergency Transport: A Multibiomarker Assessment Of Neonatal Rds Transfers ​, Eyüp Sari, Şeri̇fe Suna Oğuz, Mehmet Semi̇h Demi̇rtaş, Bensu Bulut, Medi̇ne Akkan Öz, Murat Genç, Ayşenur Gür, Ümi̇t Alper Özcan, Hüseyi̇n Mutlu, Rami̇z Yazici

Turkish Journal of Medical Sciences

Background/aim: The aim was to compare the pre- and posttransport levels of systemic inflammatory markers in neonatal infants transported to a tertiary intensive care unit via emergency health services with a neonatal respiratory distress syndrome (nRDS) diagnosis and to assess the quality of transport.

Materials and methods: This retrospective study was conducted between January 2019 and December 2023. A total of 117 nRDS patients’ emergency transports were included in the study. Demographic data, transfer time, intubation, cold treatment, cardiopulmonary resuscitation (CPR), and pre- and posttransport laboratory parameters were obtained retrospectively. The statistical analysis was performed using IBM SPSS Statistics (Version …

Effect Of Vnotes Hysterectomy With Uterosacral Ligament Suspension On Overactive Bladder Symptoms In Patients With Pelvic Organ Prolapse: A Retrospective Cohort Study ​, Gonca Türker Ergün, Mahmut Kuntay Kokanali, Duygu Tuğrul Ersak, Meli̇ke Doğanay, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

Background/aim: To evaluate the anatomical and functional outcomes following vaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy combined with bilateral uterosacral ligament suspension in patients with apical prolapse and concomitant overactive bladder symptoms.

Materials and methods: This retrospective cohort study was conducted at a single tertiary referral center. Women with symptomatic apical prolapse (stage ≥ II) and concomitant overactive bladder symptoms were included. All patients underwent vNOTES hysterectomy with bilateral uterosacral ligament suspension. Anatomical outcomes were assessed using the Pelvic Organ Prolapse Quantification (POP-Q) system, whereas functional outcomes were evaluated using validated questionnaires, including the Pelvic Floor Distress Inventory-20 (PFDI-20), …

Association Between Mri-Based Tumor-To-Skin Distance And Axillary Lymph Node Metastasis In Breast Cancer ​, Hi̇kmet Pehlevan Özel, Seçi̇l Gündoğdu, Eda Şahi̇ngöz, Ebru Menekşe, Mesut Tez

Turkish Journal of Medical Sciences

Background/aim: Axillary lymph node (ALN) status is a major prognostic factor in breast cancer and influences both survival outcomes and treatment planning. Noninvasive predictors of nodal metastasis are of clinical interest. Tumor-to-skin distance (TSD) has been proposed as a potential anatomical marker; however, standardized data based on magnetic resonance imaging (MRI) remain limited.

Materials and methods: This retrospective study included 98 female patients with pathologically confirmed breast cancer who underwent preoperative breast MRI between 2020 and 2025. Patients with prior breast or axillary surgery, distant metastasis, multifocal or multicentric disease, or inadequate MRI quality were excluded. TSD was measured on …

Standardizing Group Visits For Gestational Diabetes Education: A Quality Improvement Initiative In An Outpatient Maternal-Fetal Medicine Clinic, Nha Nguyen

Master's Projects and Capstones

Objective: At an outpatient maternal-fetal medicine clinic in Northern California, gestational diabetes mellitus (GDM) education is delivered inconsistently across nurse practitioners (NPs) and registered dietitians (RDs), with no standardized curriculum, referral criteria, or educational materials. Aim: By August 12, 2026, this project aimed to develop and implement a standardized GDM group visit framework for NPs, RDs, and scheduling staff in maternal-fetal medicine clinic, increasing compliance with standardized referral, enrollment, and educational processes from a baseline of 0% to 50%. Methods: Using baseline observations, workflow assessment, stakeholder input, and a literature review, the QI team developed standardized bilingual slide …

Reducing Variation, Improving Outcomes: Standardizing Gestational Diabetes Mellitus Education In A Clinical Microsystem, Thanh Le

Master's Projects and Capstones

Objective: Variations in referral, scheduling, delivery of educational information, patient materials, and documentation hampered the quality of gestational diabetes mellitus (GDM) education in the outpatient maternal-fetal medicine clinic. Purpose: The aim of the quality improvement project was to boost adherence to a standardized GDM group education framework from 0 to 50% in the course of 12 weeks and assess attendance at group visits. Methods: The microsystem analysis was conducted based on observations of group visits conducted in Spanish and English, examination of current processes and resources in use, educator pre-survey, SWOT analysis, and cause and effect analysis. The implementation of …

Motherhood-Defining Memories And Narrative Identity Awareness In Relation To Psychological Wellbeing And Maternal Functioning Following A Parenting Program, Christin Camia, Antje Von Suchodoletz, Michelle P. Kelly

All Works

Introduction – Drawing on previous research showing that self- and relationship-defining memories relate to psychological and relational functioning, this study began to explore motherhood-defining memories and their relation to psychological wellbeing and maternal functioning within a parenting program context. The study aimed to examine whether participation contributes to the narrative coherence of motherhood-defining memories. Methods – Participants were 155 mothers from diverse cultural backgrounds (M age = 32.85 years, SD age = 5.20) residing in the United Arab Emirates (UAE). Seventy-five mothers participated in an eight-session parenting program, and 80 mothers served as controls in a comparison group. Motherhood-defining memories …

Addressing Food Insecurities Through Staff Education In The Rural Health Setting, Angela Dawn Suttle

Walden Dissertations and Doctoral Studies

Rural America, including Arkansans, face a number of social determinants of health (SDOH) including food insecurities (FIs) and the inability to access nutritious food. FIs contribute to poor outcomes and increases healthcare utilization. Inconsistent screenings for FIs in adults living in the rural health clinic (RHC) setting, lack of standardized workflows, and failure to provide community resources when FI is identified represents a significant gap in practice. Purpose: The purpose of this Doctor of Nursing Practice (DNP) staff education project was to increase utilization of screening tools for FI, implement a standardized workflow, and provide patients with resources to improve …

Implementation Of A Nurse-Led Self-Measured Blood Pressure Program In Rural Primary Care, Stephanie Marie Montgomery

Walden Dissertations and Doctoral Studies

Hypertension remains a leading modifiable risk factor for cardiovascular morbidity and mortality, yet blood pressure control remains suboptimal among many adults, particularly those receiving care in rural primary care settings. Reliance on office-based blood pressure measurements may limit opportunities to identify uncontrolled hypertension and actively engage patients in disease self-management. This Doctor of Nursing Practice quality improvement project evaluated the implementation of a standardized self-measured blood pressure (SMBP) program for adult patients with hypertension in a rural primary care practice. The intervention included validated home blood pressure monitors, standardized patient education, teach-back to verify measurement competency, structured home blood pressure …

Staff Education To Improve Hand Hygiene And Personal Protective Equipment Compliance, Suliat Oluwa

Walden Dissertations and Doctoral Studies

This doctoral project is a staff education initiative designed to strengthen hand hygiene and personal protective equipment (PPE) practices among interdisciplinary staff in a long-term care (LTC) facility. The practice problem addressed inconsistent hand hygiene and PPE use across shifts and departments, contributing to healthcare-associated infections (HAIs). Because LTC residents are highly vulnerable due to advanced age, multiple comorbidities, and shared living environments, improving adherence to infection prevention practices is essential for enhancing resident safety, reducing preventable infections, and supporting compliance with Centers for Disease Control and Prevention (CDC) and Centers for Medicare & Medicaid Services (CMS) infection prevention standards. …

Staff Education To Improve Staff Knowledge Of Evidence-Based Strategies That Support Medication Adherence Among Patients Diagnosed With Depression In The Outpatient Clinic Setting, Comfort Aziwung Awungafac

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice project was an evidence-based practice staff education initiative designed to improve staff knowledge of evidence-based strategies that support medication adherence among patients diagnosed with depression in an outpatient clinic. Medication nonadherence is associated with poor treatment outcomes, symptom relapse, and reduced quality of life, highlighting the need for staff education on adherence-promoting interventions. The practice-focused question examined whether a structured educational intervention would improve staff knowledge of evidence-based medication adherence strategies over an 8-week period.

Weekly Team Validation Rounding Focused On Chlorhexidine Gluconate Bathing And Bath Completion And Documentation Compliance, La-Toya Therese Fong

Walden Dissertations and Doctoral Studies

This quality improvement project evaluated whether weekly team validation rounding improved chlorhexidine gluconate (CHG) bath completion and documentation compliance among eligible adult inpatients, with particular attention to differences in compliance outcomes between Pod 5C and Pod 4B. Background. Hospital-acquired infections continue to increase morbidity, mortality, length of stay, and healthcare costs. Although CHG bathing is an evidence-based strategy for reducing infection risk and the transmission of multidrug-resistant organisms, inconsistent documentation at the practicum site limited accurate monitoring of compliance across validation data, electronic medical record documentation, and DOMO reports. Method. Participants included eligible adult inpatients admitted within the previous 24 …

C-Reactive Protein–Albumin–Lymphocyte (Cally) Index As A Novel Inflammatory Marker For Sarcopenia: Evidence From A Cross-Sectional Study ​, Yasemi̇n Polat Özer, Merve Güner, Serdar Ceylan, Engi̇n Çeşmeci̇, Cafer Balci, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Mert Eşme

Turkish Journal of Medical Sciences

Background/aim: Sarcopenia is a geriatric syndrome characterized by progressive impairments in skeletal muscle mass and performance, with chronic low-grade systemic inflammation playing a pivotal role in its development. The C-reactive protein–albumin–lymphocyte (CALLY) index reflects inflammatory burden alongside immune and nutritional status; however, its association with sarcopenia in older populations has yet to be sufficiently elucidated. The present study investigates the relationship between CALLY index values and probable sarcopenia (PS) in a large cohort of geriatric outpatients.

Materials and methods: Included in this retrospective cross-sectional study were 2042 geriatric outpatients aged ≥65 years who were assessed between May 2022 and March …

Association Of Occupational Lead Exposure With Erythrocytic Parameters And Nitric Oxide–Related Metabolites: A Case-Control Study ​​, Meli̇h Gaffar Gözükara, Servet Bi̇rgi̇n İri̇taş, Deni̇z Özkan Vardar, Lütfi̇ye Tutkun, Özlem İri̇taş, Serdar Deni̇z, Vugar Ali̇ Türksoy, Engi̇n Tutkun

Turkish Journal of Medical Sciences

Background/aim: Occupational lead (Pb) exposure remains a significant public health concern due to its persistent presence in industrial environments and its cumulative toxic effects. Although the hematological and neurological consequences of Pb exposure are well documented, early vascular effects and the mechanisms associated with potential endothelial impairment remain unclear. This study aimed to investigate the associations between Pb exposure, erythrocytic parameters, and nitric oxide (NO)–related metabolites (asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], arginine, homoarginine, and citrulline) to identify early biomarkers that may suggest impairment in NO-related pathways.

Materials and methods: This case-control study included a strictly selected cohort of 125 …

Vitamin D Deficiency, Depression Severity, And Suicide Risk: Evidence From Patients With Major Depressive Disorder ​, Eli̇f Küçük, Feri̇de Uysal, Seda Şenkardeş Kandemi̇r, Özgür Özkalayci, Canay Pamukçu, Ni̇hal Taşteki̇n, Meri̇h Altintaş

Turkish Journal of Medical Sciences

Background/aim: Major depressive disorder (MDD) is a common psychiatric condition characterized by depressive symptoms and suicide-related clinical features. Vitamin D status has been investigated as a potential clinical correlate of depression and suicidal ideation, but the direction and specificity of these associations remain uncertain. This cross-sectional study aimed to examine the associations among serum 25-hydroxyvitamin D [25(OH)D] levels, depressive symptom severity, suicidal ideation, and suicide-related cognitive–affective dimensions in adults diagnosed with MDD.

Materials and methods: This cross-sectional study included 97 adults aged 18–65 years who were diagnosed with MDD according to DSM-5 criteria. Depressive symptom severity and suicide-related outcomes were …

Influenza, Covid-19, And Pneumococcal Vaccination Status Among Adults In Türkiye ​, Gamze Şanlidağ İşbi̇len, Serap Gençer, Hüsnü Pullukçu, Meltem Taşbakan, İftahar Köksal

Turkish Journal of Medical Sciences

Background/aim: Vaccines reduce morbidity and mortality caused by infectious diseases that threaten public health. Lifelong immunization programs are essential for the entire population. This study assessed adult vaccination uptake for influenza, pneumococcal, and coronavirus disease 2019 (COVID-19) vaccines in Türkiye and examined the barriers and factors influencing vaccination decisions.

Materials and methods: This cross-sectional survey was designed and conducted by the Immunization Working Group of the Turkish Society of Clinical Microbiology and Infectious Diseases. A 19-item questionnaire was administered to individuals aged 18 years or older to assess influenza, pneumococcal, and COVID-19 vaccination status. The questionnaire collected data on demographic …

Histomorphological Changes In Human Septal Cartilage Stored In Different Preservation Solutions ​, Özlem Akkoca, Aki̇f Si̇nan Bi̇lgen, Harun Çoban, Fatma Aslan Yay, Zeynep Kaptan, Funda Balkiliç Akkaya, Rahmi̇ Kiliç, Sami̇ Engi̇n Muz

Turkish Journal of Medical Sciences

Background/aim: To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery.

Materials and methods: A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically …

Demographic And Clinical Characteristics Of Frequent Users Of Emergency Medical Services In Türkiye ​, Burak Bekgöz, İshak Şan

Turkish Journal of Medical Sciences

Background/aim: Overuse of emergency medical services (EMS), particularly unnecessary ambulance requests, places considerable strain on limited healthcare resources and can delay responses to urgent cases. The present study analyzes the demographic characteristics, diagnoses, urgency, and hospital transfer status of frequent users of EMS in Türkiye.

Materials and methods: Included in the study were 41,113 patients who requested EMS four or more times within a year (defined as frequent users for the purpose of the study), excluding interhospital transfers. Data were accessed from the Emergency Medical Services Automation System (ASOS) database, which contains details of patient demographics, diagnoses, triage codes, reasons …

Perioperative Effects Of The Quadratus Lumborum Block In Percutaneous Biliary Drainage: A Prospective Randomized Controlled Study ​, Seyyi̇d Furkan Kina, Can Ozan Yazar, Cem Koray Çataroğlu, Erdi̇ Tangobay, Sadik Ahmet Uyanik, Savaş Altinsoy, Reyhan Polat, Jüli̇de Ergi̇l

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to evaluate the effect of the quadratus lumborum block (QLB) on intraoperative opioid consumption in patients undergoing percutaneous biliary drainage (PBD).

Materials and methods: A total of 57 patients who met the inclusion criteria were randomized into two groups: the sedation group (Group 1, n = 26) and the sedation with QLB group (Group 2, n = 26). The groups were compared in terms of intraoperative anesthetic consumption, vital parameters, postanesthesia care unit (PACU) recovery times, postoperative visual analog scale (VAS) scores, postoperative analgesic consumption, and clinician and patient satisfaction. The study was …

Measurement Of Resection Volume Using Computed Tomography 3d Modeling In Lung Cancer Patients And Survival Analysis ​, Aykut Kankoç, Muhammet Tarik Aslan, Muhammet Sayan, Ali̇ Çeli̇k, Cüneyt İsmai̇l Kurul, Abdullah İrfan Taştepe

Turkish Journal of Medical Sciences

Background/aim: The prognostic significance of the volumetric extent of lung resection in nonsmall cell lung cancer remains uncertain. Three-dimensional computed tomography allows quantitative assessment of resected lung parenchyma, but the relationship between resection volume ratios and oncologic outcomes has not been clearly established. The aim in this study was to evaluate the prognostic value of three-dimensional computed tomography-derived resection volume ratios for disease-free survival after surgery for nonsmall cell lung cancer.

Materials and methods: This single-center retrospective study included 141 patients who underwent anatomical resection with systematic mediastinal lymph node dissection between 2010 and 2021. Resection volume, ipsilateral lung volume, …

Lactate Dehydrogenase-To-Albumin Ratio As A Novel Prognostic Biomarker For 28-Day Mortality In Thoracic Trauma: A Single-Center Retrospective Cohort Study ​, Özgür Ömer Yildiz, Şükrü Yorulmaz, Eray Çinar, Hüseyi̇n Mutlu, Rami̇z Yazici, Ayşenur Gür, Medi̇ne Akkan Öz, Bensu Bulut, Mustafa Sirri Kotanoğlu, Hakan Güner

Turkish Journal of Medical Sciences

Background/aim: Thoracic trauma accounts for approximately 25% of all trauma-related deaths and remains a significant public health challenge. Early identification of high-risk patients is essential for improving clinical outcomes. The present study evaluates the prognostic value of the lactate dehydrogenase-to-albumin ratio (LDAR) in predicting 28-day mortality in patients with thoracic trauma.

Materials and methods: This retrospective observational study was conducted at a Level 1 trauma center between September 2022 and February 2025, and included adult patients presenting with thoracic trauma who underwent thoracic computed tomography. Demographic characteristics, clinical parameters, laboratory values, and 28-day mortality were analyzed. Receiver operating characteristic (ROC) …