Digital Commons Network^™

A Randomized Study Of Digital Versus Genetic Counselor Return Of Actionable Genetic Research Results To Biobank Participants (Respect3 Study), Anuja Rajendra Godbole, Elisabeth Wood, Brian Egleston, Lily Hoffman-Andrews, Sarah Brown, Sarah Howe, Sanjana Shastri, Rajia Mim, Justin Feng, Anjali Owens, Susan Domchek, Reed Pyeritz, Bryson Katona, Staci Kallish, Giorgio Sirugo, Joellen Weaver, Linda Fleisher, Kuang-Yi Wen, Elena Elkin, Katherine Nathanson, Daniel Rader, Angela Bradbury

Department of Medical Oncology Faculty Papers

BACKGROUND: There is consensus that research participants should be informed about plans for return of genetic research results. However, best practices for return of results in large biobank and cohort studies do not exist currently, and how best to communicate actionable genetic research results remains unclear. While having genetic counselors disclose these results may be ideal to ensure understanding, minimize distress, and optimize medical follow-up, genetic counselor (GC) workforce shortages and costs are barriers. The RESPECT3 study evaluates whether digital delivery alternatives for pre-disclosure education and return of actionable genetic research results is non-inferior to remote telehealth disclosure by a …

Prevalence Of Fall Among Elderly In Rural Sabah And Its Associated Factors, Khalid Mokti, Mohd. Yusof Ibrahim, Syed Sharizman Abd Rahim, Mohammad Saffree Jeffree, Mazlinda Musa, Mohd. Rohaizat Hassan, Yugo Shobugawa, Muhammad Aklil Abd Rahim, Ahmad Faizal Roslan, Mervynn Koon Kar-Wai

Jurnal Keperawatan Indonesia

Falls are a leading cause of injury among older adults, often resulting in significant physical, psychological, and social consequences. This study aims to determine the factors that contribute significantly to fall risks among the older adults in rural Sabah. A cross-sectional community study was conducted in the Kudat Division, Sabah, Malaysia from January to June 2021. Using multistage random sampling, 700 adults aged ≥60 years were recruited, excluding those with severe disability, mental illness, or institutionalized. Data were collected through face-to-face interviews with a structured questionnaire adapted from the validated Japanese Gerontological Evaluation Study (JAGES) tool, and anthropometric measures were …

The Effectiveness Of Psychoeducation And Mind Mapping In Preventing Early Marriages In Central Java, Indonesia, Eviyati Aini Muriana, Mardiyono Mardiyono, Lanny Sunarjo, Melyana Nurul Widyawati

Jurnal Keperawatan Indonesia

During the COVID-19 pandemic, the number of early marriages increased. Early marriage causes biological and psychological problems in the mother and her baby. The combination of psychoeducation and mind mapping emerged as a preventive effort against early marriage. The aim of this study was to analyze the effectiveness of this combination in preventing early marriage in Central Java, Indonesia by influencing adolescents’ knowledge and intentions. This study was conducted using a convergent mixed-methods design. For the quantitative phase, the pre-test – post-test control group experimental design was used, while in the qualitative phase, a thematic analysis was performed using focus …

Determining A Likely Mechanism Of Missingness In Repeated Measures Sleep Data From Wearable Fitness Trackers: Longitudinal Analysis, Kate Mobley, Kevin B. Gittner, Karen Nielsen, Lauren Matheny, Gita Taasoobshirazi, Charles Natuhamya, Monica H. Swahn

Faculty Articles

Background: Wearable fitness trackers have become a valuable tool in public health research due to their ability to collect large-scale, individual-level data at a low cost. Because of this, wearables have the potential to mitigate the urgent need for health research in low-resource settings. However, their use has been largely limited to high-income settings, and a major challenge remains: high rates of missing data. This problem may be exacerbated in low-resource environments where logistical and operational barriers further complicate data collection. Wearable sleep data collected in an urban informal settlement in Uganda during The Onward Project on Well-being and Adversity …

Relationship Between Immune Profile And Respiratory Parameters In Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis, Shehab M. Abd El-Kader, Tamer M. El-Saeed, Marwa M. I. Ismaeel, Mohamed F. El-Banna, Ahmed M. Aboeleneen, Amany G. Atiaa, Fatma A Hegazy, Mona M. Abdelkhalek

Journal of Medical Rehabilitation Science

Background: Children with Down Syndrome (DS) exhibit immune dysregulation and increased susceptibility to severe pneumonia. While associations between immune status and infection risk are known, the relationship between specific baseline immune markers and respiratory parameters at the initial presentation of acute pneumonia in this population is unclear. Objective: To investigate the correlation between baseline serum immunoglobulin levels, white blood cell count (WBCs), and baseline respiratory parameters (respiratory rate and arterial oxygen saturation) in children with DS presenting with acute pneumonia. Material and methods: This descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior …

Relationship Between Neck Muscle Cross-Sectional Area With Craniovertebral Angle Among The Subjects With Chronic Neck Pain, Mohamed Faisal Chevidikunnan, Mohammed Sati Alharbi

Journal of Medical Rehabilitation Science

Background: Neck pain is a common condition affecting many people worldwide. However, the relationships between neck muscle cross-sectional area (CSA), and craniovertebral angle (CVA), in chronic neck pain patients remains poorly understood. This study aims to investigate the association between these factors among the subjects with chronic neck pain. Methods: This was a cross-sectional study design, where 21 patients presenting to radiology department at King Fahd Hospital, Madina with chronic neck pain were included. They aged between 25–55 years, which includes both male and female subjects, who have not undergone any of neck or shoulder surgery, subjects without previous local …

Limb Dominance Does Not Affect Single-Leg Hop Performance In Non-Injured Young Athletes, Rawan Aldhabi

Journal of Medical Rehabilitation Science

Background: The concept of leg dominance is important in clinical settings. Single-leg hop (SLH) tests are frequently used to assess injury-risk and guide return-to-sport decision after lower-limb injury, yet the influence of limb dominance on SLH performance in non-injured young athletes remains unclear. The aim of the study was to examine the influence of limb dominance on SLH test performance in young healthy athletes, and to explore the relationships among different types of SLH tests. Methods: Forty-seven healthy collegiate athletes (mean age 21.44 ± 3.5 years; 26 males and 21 females) completed three SLH tests: single hop for distance (SHD), …

Predictive Role Of Mindset And Neuroplasticity Knowledge On Epistemological Beliefs Among Academic Doctors, Fahad A Somaa

Journal of Medical Rehabilitation Science

Background: Neuroplasticity the brain's capacity for structural and functional reorganization, plays a central role in learning, adaptation, and professional development. Educators' understanding of neuroplasticity, together with their mindset, may influence their epistemological beliefs and teaching practices. Objectives: The purpose of this study was to examine the extent to which mindset and neuroplasticity knowledge predict epistemological beliefs among academic doctors working in medical and rehabilitation education. Materials and Methods: A cross-sectional survey was undertaken among the 309 academic doctors working in medical colleges and teaching hospitals. Demographics, neuroplasticity knowledge, mindset and epistemological beliefs were the primary outcome measures and collected data. …

An Exploration Of Therapists' Perspectives On Treatment Approaches And Outcomes For Trigger Finger In Saudi Arabia, Badr F. Alduqsi, Naif B. Abudken, Hatim A. Al-Johani, Ahmed M. Bajunayd

Journal of Medical Rehabilitation Science

Background: Trigger finger (stenosing tenosynovitis) is a common hand condition characterized by pain, stiffness, and locking of the affected digit. Although conservative management strategies, particularly splinting and corticosteroid injections, are widely implemented in clinical practice, there is currently no universally accepted gold standard for the treatment of trigger finger. Furthermore, regional evidence describing therapists' preferences and clinical decision-making processes in Saudi Arabia remains limited. Objectives: This study aimed to explore the perspectives of occupational therapists, physical therapists, and physicians in Saudi Arabia regarding preferred conservative treatment approaches for trigger finger, and to identify the key factors influencing clinical decision-making and …

Prevalence And Association Between Major Depressive Disorder And Cognitive Impairment In Hemodialysis Patients At King Abdulaziz University Hospital, Jeddah, Saudi Arabia, Faten N. Alzaben

Journal of Medical Rehabilitation Science

Objectives: Patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis experience a substantial psychological and cognitive burden. This study aimed to determine the prevalence of major depressive disorder (MDD) and examine its association with cognitive impairment among patients receiving hemodialysis. Materials and Methods: A cross-sectional study was conducted among 30 consecutive patients aged 18–65 years undergoing maintenance hemodialysis at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Major depressive disorder was diagnosed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), with cognitive impairment defined as a MoCA score …

(Giga)Time For The Era Of Ai: Virtual Multiplex Immunofluorescence From Routine H&E For Large Populations, Shao-Ping Yang, Dihua Yu

Faculty, Staff and Student Publications

No abstract provided.

Ventilator Weaning Through Spontaneous Breathing Trials In Children With Tetralogy Of Fallot In The Picu: A Case Report, Megah Fitrian, Kadek Ayu Erika, Muhammad Yunus

Jurnal Keperawatan Indonesia

Tetralogy of Fallot (TOF) is a congenital heart defect that causes chronic low oxygen levels, increased right ventricular workload, and a higher risk of complications. Weaning mechanical ventilation in patients with TOF is particularly challenging due to right ventricular dysfunction, muscle weakness, and the risk of heart failure. This study evaluates the use of a spontaneous breathing trial (SBT) strategy with pressure support ventilation (PSV) mode for mechanical ventilation weaning in pediatric patients with TOF. An observational study was conducted on a six-year-old pediatric patient with TOF and a cerebral abscess who underwent mechanical ventilation weaning using the SBT technique …

The Role Of Health Workers In Interprofessional Collaboration For Cancer Patient Navigators: A Scoping Review, Agung Subakti Nuzulullail, Aulia Diah Rahayu, Rury Nindya Taluphyta, Ika Arif Lidiyana, Mohamad Rusdiyansyah, Petrus Paris Rumsori, Riyati Riyati, Suci Wahyu Hariyanto, Wa Ode Umi Kalsum, Sri Hartini

Jurnal Keperawatan Indonesia

Cancer remains a leading cause of death worldwide. The complexity of cancer care demands strong interprofessional collaboration (IPC), particularly within cancer patient navigator (CPN) programmes. However, research examining IPC in the context of CPN implementation is still limited. This scoping review aims to explore the various roles of healthcare workers in the IPC process within cancer navigator programme interventions. The review was conducted using four databases: PubMed, Clinical Key, EBSCOhost, and ScienceDirect. The Arksey and O'Malley framework was used to address the research question: “What is the role of health workers in interprofessional collaboration within cancer patient navigation?” Study selection …

Prescribed Aerobic Exercise And Sport-Related Concussion Recovery: A Validation Case Series, Lacy L. Chapel, Tamara C. Valovich Mcleod

Clinical Practice in Athletic Training

Active rehabilitation, including prescribed sub-symptom threshold aerobic exercise implemented during the acute phase of recovery after sport-related concussion, has been shown to facilitate recovery and reduce the risk of persisting postconcussion symptoms. The purpose of this validation case series was to evaluate currently available external evidence regarding the effects of prescribed aerobic exercise interventions on recovery after sport-related concussion. For this study, the patient population included college athletes diagnosed with a sport-related concussion who participated in at least 5 days per week of supervised, prescribed aerobic exercise, based on graded aerobic exercise testing and heart rate threshold. Our study findings …

A Review Of Mentorship And Recruitment Strategies For Minority Athletic Training Students, Dariana M. Brown

Clinical Practice in Athletic Training

The underrepresentation of minority athletic trainers remains a critical issue, affecting both the profession and the quality of patient care. While patient demographics continue to diversify, the athletic training workforce has not kept pace, leading to potential communication barriers, mistrust, and inadequate culturally competent care. This review examines whether culturally tailored mentorship programs and targeted recruitment initiatives improve retention, career satisfaction, and diversity in athletic training compared to standard methods. By analyzing studies on underrepresented minority students in athletic training, the review highlights key institutional barriers and systemic factors impacting recruitment and retention. Findings suggest that tailored mentorship and supportive …

Acute Management Of A Hamate Fracture In A Collegiate Baseball Player: A Disablement Model Case Study, Kayleigh A. De Koker, Cory E. Barton, Lindsey E. Eberman

Clinical Practice in Athletic Training

The purpose of this disablement model case study was to outline a collegiate baseball player with an isolated hamate fracture including the injury evaluation, diagnosis, and acute management. During a tournament game, the collegiate career of the patient ended abruptly following an injury sustained while at bat. The patient attempted to bat again but encountered significant difficulty due to the increasing pain in his hand. Consequently, the athletic trainer was called out for an on-field examination. The patient presented with no edema or ecchymosis but severe pain in the hypothenar eminence. This patient also presented with decreased grip strength with …

Weekly Fluctuations Of Plasma Amyloid-Beta In Alzheimer’S Disease: Implications For Biomarker Reliability, Andy Delgado, Kanisa Davidson, Danitra Parker, Jaleesa Bryant, Vicki Winstead, Mustafa Yildiz, Carolyn E Z Pickering, Andrew M Pickering

Faculty, Staff and Student Publications

No abstract provided.

Impact Of Tropical Cyclones On Food And Nutrition Security: A Global Scoping Review And Thematic Analysis, Patience M. Chiotha, Budi Haryanto

Jurnal Epidemiologi Kesehatan Indonesia

The increasing frequency and intensity of tropical cyclones driven by climate change pose growing threats to food and nutrition security. Globally, an estimated 80–90 tropical cyclones occur annually, affecting approximately 119 million people. Evidence regarding their impact on food systems, dietary patterns, and nutritional status remains fragmented. This scoping review aimed to map global evidence on the impacts of tropical cyclones on food and nutrition security, identify key pathways of impact, and examine affected indicators at household and individual levels. The review followed Joanna Briggs Institute guidelines and PRISMA-ScR. Searches were conducted in PubMed/MEDLINE, Web of Science, Scopus, and Google …

Breast Cancer-Derived Extracellular Vesicle Mir-425-5p (Mir-425) Promotes Brain Metastasis Via Activating Astrocytes Through The Novel Mir-425-Znf24-Ccl8 Signaling Axis, Grace L Wong, Munazza S Khan, Sara Manore, Shivani Bindal, Ravi Singh, Hui-Wen Lo

Faculty, Staff and Student Publications

Mechanisms underlying breast cancer brain metastasis (BCBM) are still not well understood. Here, we identified that BCBM patient serum contained extracellular vesicles (EVs) with high levels of microRNAs (miRNAs)-107 and -425. Levels of miR-107 and miR-425 were elevated in brain metastases, and the elevation was associated with poor patient prognoses. Ectopic expression of miR-107 and miR-425 promoted mammospheres; however, the inhibition of miR-425, but not miR-107, suppressed breast cancer mammosphere formation. We further observed that EVs from miR-425-overexpressing breast cancer cells strongly activated astrocytes whereas their inhibitors abrogated the effect. Conditioned media from miR-425-activated astrocytes promoted mammospheres. To elucidate how …

Evaluating Forearm Strength Variability In Collegiate Tennis Players Over The Course Of A Competitive Season, Jeffrey Williams, Payton Jensen, Kevin Laudner

Clinical Practice in Athletic Training

The muscles of the forearm undergo routine, forceful, and repetitive contractions while playing tennis and may experience adaptive changes that can precede injury. An understanding of forearm strength profiles of tennis players following a competitive season would assist clinicians’ evidence-based management of the forearm’s readiness for training, competition, and return-to-sport participation. Therefore, the purpose of this study was to explore the effects of a competitive tennis season on forearm strength among collegiate tennis athletes. A prospective, case-series design was used to examine a convenience sample of 15 asymptomatic NCAA Division I tennis players (males = 10, height = 182.88 [SD …

Quality Of Athletic Training Services For Lower Extremity Injuries, Katie Sniffen, Michael Rozier, Katherine Stamatakis, Paula Buchanan, Janet E. Simon, Leslie Hinyard

Clinical Practice in Athletic Training

The use of patient-reported outcomes in athletic training is inconsistent, limiting the ability to communicate service quality and value to key stakeholders. The objective of this study is to calculate meaningful quality outcome measures for athletic training services for lower extremity injuries in high school student-athletes. Data were collected from a subset of the National Athletic Treatment, Injury and Outcomes Network Surveillance Program and a convenience sample of high school student-athletes with patient-reported outcome measures for lower extremity time-loss injuries. Failure-toprogress proportions (FTPPs) were calculated using the Knee Injury and Osteoarthritis Outcome Score (KOOS) for knee/thigh injuries and the Foot …

Recurrent Urinary Tract Infections In An Elite Level Diver: A Disablement Model Case Study, Matt O'Sullivan, Dominique M. Stevens, Lindsey E. Eberman

Clinical Practice in Athletic Training

This article presents a case of complicated and recurrent pyelonephritis, an infection of 1 or both kidneys, in an elitelevel diver. Urinary tract infections (UTIs) are among the most common outpatient infections in the United States; most are uncomplicated and resolve without significant mortality or morbidity. However, UTIs have the potential to present significant clinical challenges if the UTI becomes complicated or recurrent. Additionally, recurrent UTIs can carry a significant burden to both the individual patients and the larger healthcare system. The current paper reviews the epidemiological literature surrounding UTIs, the significant impact they have on a patient’s health-related quality …

Comfort Level Of Collegiate Student-Athletes In Opposite And Same-Gender Patient/Provider Relationships In Athletic Training, Samantha Dickie, Yashu Tang, Sydney Nelson, Emily Madrak

Clinical Practice in Athletic Training

Gender-based comfort in patient-provider relationships is a vital aspect of athletic training care. As the profession continues to evolve—particularly with a growing number of women athletic trainers (ATs) and progression of athletic training curriculum—it is essential to understand how gender dynamics influence the comfort of collegiate athletes when receiving care. This cross-sectional survey study examined how athlete comfort varies when treated by same- versus opposite-gender ATs in general patient care and in pathology-based scenarios. Ninety-six collegiate student-athletes (62.5% female) with the mean age of 20.26 (SD 1.7) years from NCAA and NAIA institutions completed the Gender Comfort with Athletic Trainer …

Comparison Of Vibrating And Non-Vibrating Foam Roller On Hamstring Range Of Motion, Rakhoon Sung, Portia B. Resnick, Karen G. Roos, Mimi Nakajima

Clinical Practice in Athletic Training

Tightness in the distal hamstring is a common complaint among active individuals. While a foam roller is used to release muscle tension, there are limited studies about the effect using a vibrating foam roller (VFR) on hamstring flexibility and knee range of motion (ROM). For this reason, the purpose of the research was to compare the effect of a VFR and nonvibrating foam roller (NVFR) on hamstring flexibility and knee ROM in active college students. It was hypothesized that there would be more improvement in hamstring flexibility and knee ROM with a VFR than an NVFR. A randomized controlled trial …

Exploration Of Radiotherapy-Related Insufficiency Fractures In Gynaecological Cancer: A Service Evaluation Report, Vicki Hands

South West Clinical School Journal

No abstract provided.

Developing A Novel Index For Neighborhood Social Determinants Of Cardiovascular Diseases In The Cardia Study, Tao Gao, Yinan Zheng, Brian T Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Penny Gordon-Larsen, Chunyu Liu, Donald Lloyd-Jones, Kai Zhang, Lifang Hou

2020-Current year OA Pubs

Neighborhood social determinants of health have been shown to influence cardiovascular risk and the development of cardiovascular disease, but few studies have been done about early-life exposure as well as the combined effect of multiple neighborhood social determinants of health measures. Each 1-standard-deviation increase in the neighborhood social determinants of health index is associated with increased risk of coronary artery calcification at the year 7, year 15, and year 20 visits (Odds Ratios range from 1.15 to 1.17). The area under the Receiver Operating Characteristics curve ranges between 0.718 (year 7) and 0.719 (year 20). Compared to White participants, Black …

Provider And Caregiver Perspectives On Vision Services For Childhood Cancer Survivors: A Qualitative Study, Asha Parvathaneni, Luke Zabotka, Jacob Strelnikov, Allison J L'Hotta, Matthew J Ehrhardt, Maria Montoya, Kyathi Thallapureddy, Robert J Hayashi, Margaret Reynolds, Sara Malone

2020-Current year OA Pubs

PURPOSE: This study qualitatively explored barriers and facilitators to accessing supportive vision services for childhood cancer survivors with vision deficits and identified current service-delivery contexts from the perspectives of community professionals and caregivers. METHODS: Participants included caregivers and professionals who completed semi-structured interviews. Provider questions focused on patient identification and assessment, follow-up protocols, and available resources, while caregiver questions addressed navigating survivorship care, academic needs, and goals for their children. Transcripts were thematically analyzed following inductive and deductive coding. RESULTS: Six caregivers and 10 professionals completed interviews. Thematic analysis resulted in three contexts for barriers and facilitators: school settings, community …

Free Versus In Situ Right Internal Mammary Artery As A Conduit In Coronary Artery Bypass Surgery: A Meta-Analysis, Yuta Kikuchi, Tomoki Sakata, Tomonari Shimoda, Shinichi Fukuhara, Junichi Shimamura, Makoto Hibino, Tsuyoshi Kaneko, Hiroo Takayama, Hisato Takagi, Michel Pompeu Sa, Toshiki Kuno

Department of Medicine Faculty Papers

OBJECTIVES: There is debate regarding the optimal choice for a second conduit in coronary artery bypass grafting. The right internal mammary artery (RIMA) is commonly employed as a second conduit; however, it is unclear whether the free (fRIMA) or in situ (isRIMA) configuration yields superior outcomes. We performed a systematic review and meta-analysis to compare clinical outcomes between fRIMA and isRIMA as the second conduit.

METHODS: A comprehensive search of PubMed (MEDLINE), EMBASE, and CENTRAL was performed through May 2025 to identify studies comparing outcomes in patients undergoing coronary artery bypass grafting with either fRIMA or isRIMA as a second …

Post-Hemorrhagic Hydrocephalus Of Prematurity Is Associated With Disruption Of Tight Junctions And Increased Macrophage Activity In The Choroid Plexus, Maria Garcia-Bonilla, Rajiv Swarup, Owen W Limbrick, Habeebah Z Vohra, Ayodamola Otun, Konrad Mckalip, William Bernhardt, Kirill Shumilov, Marie Michenkova, Jayne Crouthamel, Mackenzie Newman, Krikor Dikranian, James P Mcallister Ii, David D Limbrick

2020-Current year OA Pubs

BACKGROUND: Previous studies on intraventricular hemorrhage (IVH), a common and severe complication of preterm birth, and subsequent post-hemorrhagic hydrocephalus (PHH), have predominantly concentrated on the secretory function of the choroid plexus (ChP), with considerably less emphasis on its barrier function. We hypothesized that PHH is associated with immune-related alterations in the junction biology of ChP. METHODS: We examined differences in tight junctions and macrophages using a neonatal mouse model of PHH (n = 40) and in vitro ChP explants (n = 22), as well as human post-mortem samples (n = 6). To test our hypothesis, we employed histology, immunofluorescence, magnetic …

High-Power Dual-Channel Chamber For High-Frequency Magnetic Neuromodulation, Xiaoyang Tian, Hui Wang, Boshuo Wang, Jinshui Zhang, Dong Yan, Jeannette Ingabire, Samantha Coffler, Guillaume Duret, Quoc-Khanh Pham, Gang Bao, Junzhe Wang, Ashok Veeraraghavan, Jacob T Robinson, Stefan M Goetz, Angel V Peterchev

Faculty, Staff and Students Publications

Objective. Several novel methods, including magnetogenetics and magnetoelectric stimulation, use high frequency alternating magnetic fields to precisely manipulate neural activity. To quantify the behavioral effects of such interventions in a freely moving mouse, we developed a dual-channel magnetic chamber, specifically designed for rate-sensitive magnetothermal-genetic stimulation, and adaptable for other uses of alternating magnetic fields.

Approach. Through an optimized coil design, the system allows independent control of two spatially orthogonal uniform magnetic fields delivered at different frequencies within a 10 × 10 × 6 cm3 chamber suitable for mouse studies. The two channels have nominal frequencies of 50 and 550 kHz …