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Efficacy And Safety Of Red Ginseng Extract Powder (Kgc05pg) In Achieving Glycemic Control In Prediabetes Korean Subjects: A 12-Week, Single-Center, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study, Namhan Cho

Oxford ICSB

Background: This study was conducted to evaluate the efficacy and safety of Red Ginseng Extract Powder (RGEP) in achieving glycemic control in prediabetic Korean subjects. Methods: The study consisted of 49 subjects in the RGEP group and 49 in the placebo group.  The participants were orally given 2 tablets of RGEP and placebo (500 mg/day twice daily in the morning and the evening within 30 min after meal), respectively.  The subjects were followed duration of 12-week.  The participants glycemic control parameters, such as fasting blood glucose levels, 30-, 60-, 90-, and 120-min blood glucose levels at 75gm oral glucose tolerance …

Ginsenoside-Based Theranostic Agents For Alzheimer's Disease: Implications For Brain Penetration, Cellular Uptake, And Anti-Aging Effects, Hak Soo Choi

Oxford ICSB

Red ginseng and its bioactive constituents, ginsenosides, have long been associated with neuroprotection and anti-aging effects, yet their limited ability to cross the blood-brain barrier (BBB) and poorly characterized biodistribution have hindered therapeutic translation. To address this, we developed a library of “ginsenoprobes” by conjugating major red ginseng components (Rg1, Rg3, Rb1, Rh2, Rk1, Rg5) and red ginseng extract (RGE) to a zwitterionic near-infrared (NIR) fluorophore (ZW800-1C), enabling real-time tracking of their fate in vitro and in vivo. All ginsenoprobes were purified to >95% homogeneity via preparative HPLC and rigorously characterized for optical properties, including molar extinction coefficients and dye-to-ginsenoside …

Icu Decision Tool Impact On Rebound Hyperglycemia, Daniel J. Donovan, Emily Highsmith, Sonya Khan, Michelle Horng

Advances in Cancer Education and Quality Improvement

Hyperglycemia, defined as a blood glucose level ≥180 mg/dL in the hospitalized patient, is linked to negative outcomes including longer hospital stays, increased infection risk, and higher morbidity and mortality rates. In addition to critically ill patients with diabetes, hyperglycemia can develop in individuals without diabetes due to factors such as steroid use, continuous tube feedings, and an elevated stress response. Patients who have uncontrolled hyperglycemia are often placed on continuous insulin infusions (CII), but rebound hyperglycemia frequently occurs after CII discontinuation if the maintenance insulin regimen (MIR) is insufficient. Implementation of a MIR decision support tool integrated within an …

Metabolite Profiling Of Chamaelirium Luteum (False Unicorn) Roots And Related Commercial Products By Hptlc And Lc-Msms, Wendy Strangman, Wilmer Perera, Wilmer Perera

Oxford ICSB

Throughout history, medicinal plants have been used as herbal treatments in women’s health.  However, they remain poorly characterized at the chemical level, limiting standardization and safety assessment. Chamaelirium luteum (false unicorn), traditionally used for reproductive health in the Eastern United States, has previously been shown to possess both conventional steroidal saponins as well as more rare open-chain saponins whose bioactivities are largely unexplored. Incorporation of C. luteum into commercial products, and subsequent overharvesting of wild populations has increased the urgency for robust methods to verify authenticity and detect adulteration. In this study, we coupled HPTLC-based profiling with detailed LC-MSMS analyses …

Hptlc: The New Front Line Of Global Botanical Surveillance, Tiên Do, Ilona Trettin, Ehab Mahran, Sonja Drobnjak

Oxford ICSB

Quality control of botanicals is approaching a breaking point. Regulators, industry, and pharmacists are now forced to answer questions faster and at larger scale than ever before: What plant is actually in the product? Is it the right species—or a look-alike? Is it pure or adulterated? Is it safe? Is the chemistry consistent? And how can labs make confident decisions when analytical capacity and staffing are finite? This presentation demonstrates how modern HPTLC— far beyond its historical role as a simple identity test— now provides clear, interpretable chemical evidence that supports analyst with a practical tool for risk-based surveillance of …

Advancements In Extraction And Co-Extraction Of Botanicals For Standardization And Efficacy, Rory Coleman

Oxford ICSB

Historically, botanicals have served human health in traditional medicine and supplementation due to their bioactive components. Efficient, clean extractions and clinical validation have become fundamental technologies, rendering access to libraries of efficacious products. However, cost, regulatory status, and speed to market have kept many botanicals in single or simple form. Mixtures of such single botanical extracts often require large quantities for effect, influenced by chemical composition, concentration, and delivery format. During the extraction and concentration process, exogenous "bioenhancers," e.g. piperine or oil blends for hydrophilic molecules, often become a necessity, exasperating the problem.   Here, we will delve into the development …

Botanical Hepatotoxicity: Are We Accurately Characterizing Risk Vs. Hazard, Rick Kingston

Oxford ICSB

No abstract provided.

Yeast As A "Microbial Factory", Kaila Fuller, Betsy Jean Yakes

Oxford ICSB

Yeast are eukaryotic, single-celled microorganisms that are members of Kingdom Fungi, and in the world of dietary supplements, yeast qualify as a dietary ingredient as a botanical. During fermentation, yeast naturally produce byproducts that can be harvested, purified, and sold in a dietary supplement. Advances in biotechnology have allowed for genetic modification of yeast so that yeast can produce large quantities of native or non-native constituents during fermentation, effectively making yeast a “microbial factory” for various chemicals. Chemicals produced this way can qualify as a dietary ingredient as a constituent of a botanical. Relevant examples of past submitted notifications (public …

Silent Struggles: A Qualitative Study On Mental Health Stigma And Help- Seeking Among African Individuals In The U.S, Ololade Ekwere

Dissertations

Approximately one-third of African Americans and Caribbean Blacks who require mental health services seek and utilize them (Evans & Sheu, 2019). Research has shown that stigma surrounding mental health treatment contributes to lower rates of professional help-seeking among Black Americans (Pederson, 2023). Despite the growing diversity within the Black community, limited research exists on how stigma influences professional mental health help-seeking among Africans living in the United States.

The purpose of this qualitative descriptive study was to explore the effect of public stigma on the mental health help-seeking behaviors of Africans living in the United States. Demographic data were collected, …

Supporting Early Childhood Development Through Parent And Educator Education, Hannah L. Wood

OTD Capstone Projects

This doctoral capstone was completed in partnership with Glen Leven Presbyterian Church Day School in Nashville, Tennessee, a program serving children from 6 weeks to 5 years, with the aim of supporting early childhood development through parent and educator education. The primary goal was to develop evidence-based parent newsletters on early childhood development topics, including practical strategies for daily routines. Weekly newsletters were distributed to parents and later compiled into a booklet to serve as an ongoing resource for educators. Parent survey feedback indicated that the newsletters were clear, helpful, and applicable to everyday routines. A second goal and primary …

Making The Write Connections: Cursive & Body Schema Development, Angelina Kelley

OTD Capstone Projects

This doctoral capstone project was completed at Middle Tennessee Christian School (MTCS) to address handwriting and fine motor needs across grade levels. Teachers identified a need for structured, classroom-friendly strategies to support students with dyslexia, attention challenges, and early pre-writing readiness.

The project included two components: development of a multi-sensory cursive handwriting curriculum for elementary students and implementation of a classroom-based Mat Man pilot study for preschool and transitional kindergarten students. The cursive curriculum emphasized color-coded stroke pathways, motor-based letter grouping, guided practice, repetition, and classroom application. Teacher-ready materials included laminated visual supports, portable letter cards, lesson plans, and digital …

Building Inclusive Communities: Resource And Partnership Development At Friends Life Community, Siobhan Collins

OTD Capstone Projects

Adults with intellectual and developmental disabilities (IDD) and their family systems often face barriers to meaningful participation in community activities, limiting inclusion and quality of life. This capstone project was completed in collaboration with Friends Life Community (FLC), a non-profit organization, supporting adults with IDD (friends) through community-based day programing, with emphasis on social engagement and lifelong learning. This projected aimed to promote community inclusion by shedding light on the resources available and fostering strategic partnerships within the Nashville area.

A comprehensive needs assessment identified a gap in the connection between programming at FLC and overall inclusion and advocacy within …

Effects Of Animal-Assisted Therapy In Inpatient Rehabilitation: A Reflective Study And Outline For Practice​, Anna Rosenberger

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Vanderbilt Stallworth Rehabilitation Hospital. The project aimed to collect patient feedback and preliminary qualitative data on the implementation of animal-assisted therapy (AAT) interventions within an inpatient rehabilitation setting. Project activities included a comprehensive literature review, examination of current AAT practices, collaboration with therapy dog teams regarding their work and certification processes, implementation of AAT-based occupational therapy interventions, and administration of patient surveys following sessions. Outcomes of the project included the development of a practical guidebook to support the implementation of animal-assisted therapy in clinical settings, as well as the collection of …

Promoting Safety And Reducing Fall Risk In Adults With Parkinson's Disease, Kennedie Hudson

OTD Capstone Projects

This doctoral capstone project was completed in collaboration with Bridges for Parkinson’s, a local non-profit organization that supports individuals living with Parkinson’s disease. Bridges for Parkinson’s helps to reduce financial barriers and provide exercise and fitness programs that promote functional mobility, a sense of community, and overall well-being. Fall prevention is increasingly important in older adults, especially those with Parkinson’s disease. The primary goal of this project was to gain insight into individuals with Parkinson’s disease experiences and develop research-informed community and home fall prevention and safety educational materials. An educational seminar was conducted that included a pre-survey, presentation of …

Flip For Function: Professional Development And Family Education Resources, Hayley E. Fuller

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Flip for Function, a therapeutic gymnastics program that promotes confidence, inclusion, and participation through adaptive athletics and child-led occupational therapy. The purpose of this project was to develop professional development and family education resources to enhance caregiver understanding, staff consistency, and community outreach. To address identified needs, a comprehensive parent- and school-friendly guidebook was created, including diagnosis-specific information (ADHD, autism, Down syndrome, and sensory processing differences), explanations of how movement supports regulation and development, and strategies to support skill carryover into home and school environments. Additional deliverables included diagnosis-based handouts, activity …

Development Of A Cvi Early Learning Kit For Clients Of Blind Early Services Tennessee, Emma Ruggles

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Blind Early Services Tennessee (BEST), a nonprofit organization focused on providing early intervention services for children with visual impairments. BEST currently supports more than 300 families throughout Tennessee, utilizing a multidisciplinary team approach that includes Teachers of the Visually Impaired (TVIs), Orientation & Mobility (O&M) specialists, Occupational Therapists (OTs), and Developmental Therapists (DTs). This project focused on developing kits that offered educational resources for families while also providing materials designed to support early learning in children with Cortical Visual Impairment (CVI). Deliverables included a sensory processing guide with activity ideas, QR …

Promotion And Advocation For Naveg Integration In Nicu Practices To Advance Early Intervention Vision Health, Lily A. Simmons

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Blind Early Services Tennessee (BEST), a nonprofit organization that provides early intervention services to children ages 0–5 with visual impairments and their families across the state. Serving more than 300 children and families in Tennessee, BEST offers early intervention (BEST Start), parent empowerment (BEST Advocate), and family support (BEST Together) programming. The primary goal of this project was to promote and advocate for the implementation of an early identification screening tool, the Neonatal Assessment Visual European Grid (NAVEG), a validated, non-invasive newborn vision screening tool designed to identify neurological risk for …

Iron-Based Nanoparticles As Delivery Tools, Keykavous Parang, Rajesh Vadlapatla, Ajoy Koomer, Victoria Moran, Lanie Jackson, Amir Nasrolahi Shirazi

Pharmacy Faculty Articles and Research

Iron-based nanoparticles, particularly iron oxide nanostructures (IONPs), have emerged as versatile and clinically relevant platforms for drug delivery and theranostic applications. Among these, superparamagnetic iron oxide nanoparticles (SPIONs), including magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃), are the most extensively investigated due to their biocompatibility, magnetic responsiveness, and established safety profiles. Their unique superparamagnetic behavior enables external magnetic-field-guided targeting, magnetic resonance imaging (MRI) contrast enhancement, and magnetically triggered hyperthermia, enabling simultaneous diagnosis and therapy. Surface functionalization with polymers, silica, lipids, peptides, and biomolecules further improves colloidal stability, circulation time, targeting specificity, and controlled drug …

Pharmacologic Interventions To Reduce Cardiopulmonary Bypass Induced Inflammation In Cardiac Surgery: A Scoping Review, Wyatt Anderson

Student Works

ABSTRACT

1. Structured summary

Background

Cardiopulmonary bypass (CPB) is essential in cardiac surgery but can trigger a systemic inflammatory response that contributes to postoperative complications. The scoping review conducted has a purpose to map the existing literature on pharmacologic interventions to mitigate CPB related inflammation. While several interventions demonstrated potential anti-inflammatory effects, findings were inconsistent, and no standardized pharmacologic approach is currently agreed upon.

Methods

This scoping review followed PRISMA-ScR guidelines.Both PubMed, and CINAHL were screened for studies published between 2000 and 2024 that evaluated pharmacologic interventions aimed at reducing CPB related inflammation. After screening and duplicate removal, 10 studies met …

From Admission To Readiness: Evaluating School Admissions And Supporting Early Childhood Development At Middle Tennessee Christian School, Tessa B. Barto

OTD Capstone Projects

This capstone project evaluated the admissions criteria and processes at Middle Tennessee Christian School (MTCS) to better support early childhood development and school readiness. Methods included reviewing current protocols, conducting stakeholder interviews, analyzing kindergarten-readiness trends, and comparing practices to evidence-based standards. Findings revealed variability in academic skills and highlighted social-emotional development, self-regulation, and functional independence as key areas of need. Results also emphasized the importance of a holistic admissions approach and strong family engagement in student success. In response, evidence-based recommendations were developed to enhance the admissions process. Additionally, the Early Learning Center (ELC) Classroom Support Strategies resource was created …

Developing Inclusive, Evidence-Based Curriculum And Educational Resources For Neurodiverse Learners, Cristina N. Cinca

OTD Capstone Projects

This doctoral capstone was completed in partnership with Wildflower Learning Center in Nolensville, Tennessee, a non-traditional educational program offering group academic classes within an inclusive and supportive learning environment for children with disabilities, neurodiverse learners, and neurotypical peers in grades 3–8. Wildflower Learning Center utilizes an interdisciplinary model that supports academic, social, language, and functional skill development through group-based instruction. The primary goal of this project was to develop an inclusive, evidence-based curriculum aimed at enhancing students’ interoceptive awareness through structured lesson plans, engaging activities, and supportive educational resources. A comprehensive 14-week brain class curriculum was created in both digital …

Life Skills Workshops For Young Adults With Histories Of Trauma At Crossroads Campus, Perrin G. Shuler

OTD Capstone Projects

This doctoral capstone project was completed through a partnership with Crossroads Campus, a 501(c)(3) nonprofit that provides career training in animal-related fields, offers affordable housing, and gives comprehensive support services to help young adults overcome housing and employment challenges. The purpose of this project was to address gaps in daily life skills among young adults with a history of trauma. Key outcomes included facilitating life skills workshops, developing a comprehensive workshop manual for future participants, and designing pre- and post-assessments to evaluate changes in life skills competency.

Exploring Illuminate Academy’S House Of Growth Framework: An Immersive Capstone Experience And Literature Review, Claire Grobe

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Illuminate Academy in Nashville, an educational program providing a homeschool-based alternative for children with autism and developmental disabilities. The purpose of this project was to address the agency’s need for improved understanding and communication of the House of Growth Framework among educators, families, and community partners. The primary goal of this project was to improve understanding and consistent use of the House of Growth Framework to support student engagement, regulation, and overall development. The project included a needs assessment, a comprehensive literature review, and immersive participation within the learning environment to …

Using An Administrative Lens To Facilitate Improvement Of Long-Term Acute Care Patient Outcomes Following The Continuum Of Care, Elizabeth M. Eisenga

OTD Capstone Projects

This doctoral capstone project was completed in collaboration with Select Specialty Hospital Nashville West, a local critical illness recovery hospital. Select Specialty Hospital Nashville West provides care to individuals with a range of diagnoses who require extended hospital stays, including those needing ventilator weaning. The overarching goal of this project was to improve patient outcomes using an administrative lens. To accomplish this goal, patient education materials were developed for clinical liaisons and other staff to help delineate patients' locations along the continuum of care. In addition, staff in services and a collection of resources on best practices were provided, with …

Advancing Caregiver Support In Community-Based Care: Advocacy, Resources, And Education Supporting Nicu Transition And Families With Complex Needs, Leah G. Rickard-Breeden

OTD Capstone Projects

This capstone project was completed in partnership with Nurses for Newborns (NFN), a nonprofit organization that is seeking to improve maternal and infant health outcomes across Middle Tennessee through free, in-home nursing visits. They provide education, health assessments, and connections to community resources for prenatal and postpartum mothers and their infants; specifically, those facing medical, emotional, or social barriers. The focus of this project was to create a comprehensive resource to support caregivers of infants through their transition from the NICU to home. A needs assessment revealed that families would benefit from additional support and resources to help bridge the …

Nutrition And Meal Preparation Programming And Development At E.L.I.'S House, Kara E. Nienhaus

OTD Capstone Projects

This doctoral capstone project was completed through a partnership with E.L.I.’s House in Franklin, Tennessee. E.L.I.’s House is a nonprofit organization that exists to help women and their children thrive after trauma. The desired outcome of this project was to create programming to provide education and life skills training to participants, and to develop manageable systems for grocery shopping and nutrition in the site handbook. Goals promoted occupational therapy-based skills such as meal preparation, nutrition management, cognitive flexibility, and task sequencing. The project involved creating a house recipe book with balanced meals, accessible information on basic nutritional needs for adults …

Flip For Function: Strengthening School Participation And Parent Understanding, Ashley Caceres

OTD Capstone Projects

This doctoral capstone project was completed in partnership with Flip for Function, an adaptive gymnastics program that integrates occupational therapy principles to support children with and without developmental differences. The purpose of this project was to support program growth through improved school collaboration, program evaluation, and community awareness. A literature review was conducted to examine the impact of movement-based and adaptive programming on participation and school-related outcomes for children with and without disabilities. Based on these findings, several resources were developed, including pre–post outcome measures, a caregiver survey, a student take-home flyer, and a school partnership implementation guide. These tools …

Promoting Optimal Bowel And Bladder Function Through Diet And Fluid Education At Bridges For Parkinson's, Emma R. Floum

OTD Capstone Projects

This doctoral capstone was completed in partnership with Bridges for Parkinson’s, RockSteady Boxing, a local nonprofit organization offering group fitness classes for those diagnosed with Parkinson’s Disease and other neurological disorders in Nashville and surrounding areas. The goal of this project was to educate individuals and their caregivers on the optimization of healthy bowel and bladder function, specifically in the Parkinson’s Disease population. Participants and their caregivers were given the opportunity to attend an educational seminar, including receiving an informational pamphlet. Pre and posttest survey ratings suggested that the participants’ knowledge about the topic increased. The educational pamphlet was also …

Promoting Emotional Regulation And Rest For The Parkinson's Disease Population At Bridges For Parkinson's, Charlotte Palmer

OTD Capstone Projects

This doctoral capstone was completed in partnership with Bridges for Parkinson’s, a local nonprofit offering specialized exercise programs for those living with Parkinson’s disease and other neurological disorders. The goal of this project was to develop educational resources to provide participants and care partners with practical strategies for managing sleep and emotional changes. An inservice, including handouts, was provided focusing on practical emotional regulation and sleep strategies to use during and outside of boxing classes. These resources were designed to be sustainable for agency staff and future participants. Participants demonstrated increased knowledge of the effects of Parkinson’s disease on emotional …

Flip For Function Professional Development Workshop Curriculum & Staff Education Resource, Danielle R. Olsen

OTD Capstone Projects

This doctoral capstone project was completed in collaboration with Flip for Function, an adaptive gymnastics program that promotes confidence, participation, and inclusion for children with diverse developmental needs. A needs assessment identified a gap in consistent, evidence-informed training resources to support instructors in understanding how various diagnoses impact movement, regulation, sensory processing, and participation. The purpose of this project was to develop a comprehensive professional development guidebook and staff training resource grounded in occupational therapy principles. Deliverables included diagnosis-specific content (e.g. ADHD, Autism, Down syndrome, and sensory processing differences), activity adaptations, coaching strategies, and family education handouts to support home …