Digital Commons Network^™

Alkaloid Profiling Of Narcissus Poeticus L. Bulbs And Their Inhibitory Activity Of Cholinesterases, Maël Gainche, Isabelle Ripoche, Elodie Jagu

Oxford ICSB

The Amaryllidaceae family is well known for its rich diversity of alkaloids, including lycorine- and galantamine-type structures with potent cholinesterase inhibitory properties. In this study, we investigated the phytochemical composition and cholinesterase inhibitory activity of alkaloids isolated from Narcissus poeticus L., a species native to the botanically rich Auvergne region of France. Phytochemical analysis and bioguided fractionation of bulb extracts led to the identification of three known alkaloids, pseudolycorine, norgalantamine, and 2-O-(3’-hydroxybutanoyl)-lycorine, as well as a newly characterized tetrahydroquinoline derivative, poeticine A. The inhibitory activities of these compounds against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were assessed using both a standard …

Evaluation Of Fasted And Fed Gastrointestinal Transformation Of Withania Somnifera Plant Extracts And Bioactive Compounds Via Uplc-Ms/Ms And Untargeted Metabolomics, Sarah Barr, Wendy Strangman, R. Thomas Williamson, Amala Soumyanath, Melissa Bollen

Oxford ICSB

Ashwagandha (Withania somnifera) is a widely consumed botanical supplement recognized for its anti-inflammatory, antioxidant, and anti-aging properties. Despite its extensive use, limited information exists on how its complex chemical composition changes during gastrointestinal digestion. An untargeted UPLC-MS/MS-based metabolomics approach enables analysis of discrete changes in complex mixtures. Previous in vitro studies of W. somnifera relied on simulated gastric and intestinal models composed primarily of buffers and digestive enzymes. This study advances those methods by incorporating bile salts and phospholipids under fasted and fed conditions to better simulate physiological digestion of aqueous and ethanolic extracts of W. somnifera root and leaf. …

Unmasking Ashwagandha Controversy: Safety, Toxicity, And Adulteration, Tahir Maqbool Mir

Oxford ICSB

Ashwagandha (Withania somnifera) is an adaptogenic shrub valued for its roots, which support systemic health. Increasing use has raised safety concerns about adulteration and hepatotoxicity. The roots of ashwagandha are primarily preferred for systemic health, while the leaves were traditionally reserved for topical applications to treat joint inflammation and promote wound healing.  Although generally considered safe, ashwagandha supplements have been linked to drug-induced liver injury, including cholestasis, jaundice, and pruritus. Reports from various organizations like LARB in the Netherlands indicate a rise in liver toxicity cases, possibly due to cytotoxic withafrin A and DNA-damaging withanone. A major concern is widespread …

Advancements In Botanical Toxicology, Characterization, And Regulatory Frameworks, Paula Brown

Oxford ICSB

No abstract provided.

Determinants Of Opioid-Relevant Exposure From 7-Hydroxymitragynine Products In The Evolving U.S. Marketplace, Igor Koturbash, Scott Alsbrook, George Pro

Oxford ICSB

Kratom’s U.S. market has rapidly evolved from largely botanical powders and capsules to products enriched in 7-hydroxymitragynine (7-OH), a potent mu-opioid receptor agonist that is typically present only at trace levels in leaf material. To quantify downstream behavioral health burden and contextualize it with real-world signals of product diffusion, we analyzed National Survey on Drug Use and Health (NSDUH) data (2021-2023) alongside public health alert trends and systematic online product surveillance. In NSDUH, 5.8% of adults met criteria for serious mental illness (SMI). SMI increased by 150% among adults with combined opioid use disorder (OUD) and kratom use between 2021 …

Naturally Derived Kratom Extracts: Toxicological Evaluation In Humans And Rodents, Sibyl Swift

Oxford ICSB

Peer-reviewed literature provides limited toxicological data on the consumption of naturally derived kratom extracts. Given the increasing use of kratom products, understanding their safety profile is critical for public health and regulatory decision-making. To address this gap, we conducted a rodent toxicology assessment and a controlled human clinical study. Human Clinical Study: Healthy male and female participants consumed specified kratom extracts daily for 14 consecutive days under controlled conditions. Clinical observations and biochemical markers were monitored throughout the study. Rodent Toxicology Study: Equivalent extract doses were administered to rodents for 90 days to evaluate subchronic exposure. Assessments included body weight, …

Comparison Of Total Distance And Sprint Distance Between Positions Of Division Ii Female Soccer Players, Tamas Sebestyen, Jonathan P. Bayer

Research & Creative Achievement Day

Introduction: To manage player health, minimize injury, and optimize performance in NCAA Division II soccer, this study analyzed positional demands using GPS technology. The findings provide insights into enhancing training plans and recovery based on specific positions. Methods: NCAA Division II female soccer players were tracked during sixteen in-season competitions using 10 Hz GPS wearable technology. Players were grouped into tactical roles including Wing Backs (WB), Center Backs (CB), Defensive Midfielders (6), Attacking Midfielders (10), and Forwards (9). Key metrics analyzed included Total Distance (TD), Total Sprint Distance (TSD), and Distance per Minute (D/M). Results: Forwards (9) and attacking midfielders …

Care, Capitalism, And Croissants: Interprofessional Students Take On Business Of Healthcare In Paris, Beth A. Komay, Phoebe S. Enebechi, Selma Dzamalija, Nicole A. Sharp

Research & Creative Achievement Day

The Business of Healthcare in Paris is a faculty-led study-away program that unites business, nursing, and other healthcare students in an immersive experience of global healthcare systems. The primary design of this course is around interprofessional learning that integrates coursework and cultural experiences from within the Midwest United States (US) and France. Students begin the course by visiting healthcare facilities and small alternative-therapy businesses in the US, gaining initial exposure to diverse care environments. They then travel to Paris and surrounding areas to explore comparable sites, including hospitals, an art therapy center, a residential rehabilitation facility, and small businesses providing …

Public Health Book Club, Ashia Meister, James W. Durst, Ameila Beyer, Kelly K. Freymiller, Julia I. Kunz, Jaci M. Winchell, Josephine M. Sandquist, Chloe F. Sand

Research & Creative Achievement Day

Introduction: This project describes the development and implementation of a book club focused on population health topics to promote learning, discussion, and community engagement. A public library is a safe space to host book club meetings due to its non-intimidating environment. All members of the community are welcome to participate. A book club was hosted on campus for members of the nursing cohort to attend. With a focus on public health, these book clubs build awareness, critical thinking, and community engagement around population health issues. Purpose: The promotion of a book club can improve health literacy in the community by …

Health Education For Caregivers Of Individuals With Intellectual And Developmental Disability (Idd), Madison M. Conlin, Jack Lux, Megan Hesse, Sadie Olson, Violet Nelson, Christina Chao, Anna Peterson, Johanna Shubert

Research & Creative Achievement Day

Background: Winona State University nursing students partner with Home and Community Options (HCO) during their population health clinical experience. HCO’s mission is to “empower and support people with developmental disabilities,” with a vision of ensuring that all individuals thrive and are valued members of their communities (Home and Community Options, n.d.). The Healthcare Director at HCO identified a need for additional staff education related to common health conditions affecting individuals with intellectual and developmental disabilities (IDD), including arthritis, diabetes, and depression or other mental health concerns. In response to this identified need, nursing students developed evidence-based educational strategies to enhance …

A Collaborative Approach To Strengthening Behavioral Strategies To The Arcadia School District, Mallory Arndt, Sada Stanley, Ariana Huntington, Erin Janiszewski, Syndey Graf, Josie Becker, Bailey Ripley, Dana Jones, Gabby Rinowski, Luke Garner, Hailey Schliep

Research & Creative Achievement Day

The School District of Arcadia is lacking mental health resources due to budget cuts from state and federal levels. Mental health needs have become a rising concern in recent years. With that, the guidance counselors, who traditionally supported students' emotional regulation and behavioral needs, became increasingly occupied with Academic and Career Planning requirements, leaving them with limited time to address students' mental health needs. To help address this need, Winona State University nursing students partnered with the district's guidance counselors to develop supplemental emotional management and decision-making skills-building videos that counselors could use during busy periods to support students' coping …

Natural Products As Multi Drug-Multi Target Therapeutics - From The Pharmacological Proof To New Approaches For Quantitative Quality Control, Olaf Kelber

Oxford ICSB

In the two decades since the mode of action of herbal medicinal products has been characterized as the Multi Target action of Multi Drug combinations [1,2, 3], the body of evidence supporting the general applicability of this principle to herbal health products has been exponentially increasing.  Key studies describing this principle, based on a wide range of pharmacological models, have been conducted in STW 5 and STW 5-II, herbal combinations used in the treatment of disturbances of the gut-brain interaction (DGBIs) as e.g. upset stomach and irritable bowel syndrome [2, 4]. They allow to characterize the contribution of each combination …

Medicinal Plants And One Health Drug Discovery: Plectranthus Abietanes As P-Glycoprotein Modulators, Patricia Rijo

Oxford ICSB

Cancer remains a major global health challenge, with multidrug resistance (MDR)—frequently driven by P-glycoprotein (P-gp) overexpression—significantly limiting the effectiveness of chemotherapy. Within a One Health perspective, Africa, home to five major medicinal biodiversity hotspots, represents an underexplored reservoir for natural products–based drug discovery. Among this rich flora, the genus Plectranthus (Lamiaceae) emerges as a particularly promising source of bioactive abietane diterpenes. In this work, the abietane diterpene 7α-acetoxy-6β-hydroxyroyleanone (Roy), isolated from Plectranthus grandidentatus Gürke, exhibited pronounced cytotoxic activity against several cancer cell lines. To enhance its pharmacological profile, a series of Roy ester derivatives was synthesized and evaluated for their …

Expanding Natural Product Diversity Through Biotransformation, Emerson Queiroz

Oxford ICSB

Over the past decade, natural product research has undergone a methodological revolution [1]. Modern approaches now integrate advanced metabolite profiling techniques for compound annotation and prioritization, together with high-resolution chromatographic methods that enable seamless transition from analytical to preparative scales [2]. These tools have facilitated the detection and identification of minor bioactive constituents. Nevertheless, plant extracts typically contain abundant common scaffolds with limited relevance for drug discovery. In this context, enzymatic biotransformation emerges as a promising strategy to enhance chemical diversity and unlock new structural space. Two complementary biotechnological approaches have been developed: enzymatic transformation using fungal secretomes (crude extracellular …

The Role Of Group Guidance With Psychodrama In Promoting Self-Adjustment: Does It Really Work For Adolescents?, Hanifa Salsa Bila, Dian Ari Widyastuti, Sri Tutur Martaningsih, Agungbudiprabowo Agungbudiprabowo, Taquddin Abd Mukti

Buletin Konseling Inovatif

This study aimed to examine the effectiveness of group guidance using psychodrama techniques in improving self-adjustment among students. The study employed a quantitative approach with an experimental research design, specifically a pretest–posttest control group design. The participants consisted of ten students, divided into an experimental group of five students and a control group of five students. The experimental group received group guidance with psychodrama techniques, while the control group received treatment as usual. The research participants were selected using a simple random sampling technique. Data were collected using a self-adjustment scale, which had been analyzed for validity and reliability using …

Beyond The Numbers: Supporting Young Adults With Diabetes In The Transition To Adulthood, Alexis Salkovick

Honors Projects

This project focuses on the transition to adulthood for young people with diabetes, a chronic medical condition. Both Type 1 and Type 2 diabetes are included. The main research focus is two-part: first examining this transition including barriers to health care, changes in lifestyle, and mental health, and then creating a new, innovative tool to support young adults with diabetes. An independent literature review was conducted to investigate diabetes management, barriers to health care, how transitioning to adulthood impacts diabetes care, and the importance of patient support systems. Then, a board game was developed with the dual purpose of educating …

Modulating Acute Stress Reactivity: Behavioral Interventions And Caffeine-Linked Stress Physiology In College Students, Kaitlyn Smith

Honors Theses

College students frequently rely on caffeine to manage academic demands, yet its physiological and psychological effects on acute stress remain poorly understood. Although caffeine is known to increase cardiovascular arousal and self‑reported anxiety, little research has compared different caffeine sources within the same individuals or examined whether brief behavioral interventions can buffer these effects. Self‑affirmation, a short writing exercise centered on personal values, has been shown to reduce stress reactivity, but its interaction with caffeine‑induced arousal has not been tested. This within‑subjects study examines how coffee, energy drinks, and a no‑caffeine control influence acute cardiovascular and self‑reported stress responses, and …

Glp-1 Receptor Agonists In Diabetic Foot And Ankle Care: Skeletal Liability Or A Blessing In Disguise? A Scoping Review, Daniela Lizbeth Avilez, Amanda Killeen

School of Podiatric Medicine - Student Research

Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly prescribed for glycemic control and weight reduction in patients with Type 2 Diabetes Mellitus (T2DM). Patients with T2DM exhibit elevated fracture risk despite preserved bone mineral density due to impaired bone quality and microarchitectural compromise. Whether GLP-1 RA therapy exacerbates or mitigates skeletal risk remains clinically relevant to podiatric care.

Hypothesis: We hypothesized that GLP-1 RA therapy is not associated with increased lower extremity fracture risk and may demonstrate protective trends influenced by age and duration of therapy.

Methods: A review of PubMed and Google Scholar (2010–2026) was conducted. Inclusion criteria …

An Ot Educational Program For Individuals With Upper And Lower Limb Amputations, Laurie R. Spinks Mrs, Cassandra Nelson

Spring 2026 OTD Capstone Symposium

An OT approach to reducing prosthetic abandonment with an accessible guide to promote self sufficiency and community connections for individuals with amputations.

Quantification Of Mouse Tracheal Epithelial Cell Differentiation With Cilia Defects, Olivia V. Allen

Honors Thesis

Primary Ciliary Dyskinesia (PCD) is an autosomal recessive disorder that affects 1 in every 7,500 live births. PCD results from motile cilia defects, impairing mucociliary clearance and causing chronic respiratory infections. Our lab studies include three PCD mouse lines — bgh (Spef2), nm1054 (Cfap221), and Cfap54^gt/gt (Cfap54). Prior transcriptomic data led us to hypothesize that PCD mutant mouse tracheal epithelial cells (MTECs) exhibit reduced differentiation into ciliated cells. MTECs from the trachea of the Wild Type (WT) and the PCD mutant mouse lines were cultured at an Air Liquid Interface (ALI) to start …

Sudden Cardiac Arrest & Newly Diagnosed Arrhythmogenic Cardiomyopathy In A High School Athlete, Jacob Rolfes, Brent Holtgrewe, Mike Tzianos

2026 Student Academic Showcase

A high school soccer player experienced sudden cardiac arrest during competition and required immediate CPR and AED use. Following resuscitation, physicians ruled out commotio cordis and identified findings consistent with arrhythmogenic cardiomyopathy, supported by a prolonged T-wave on EKG while all other laboratory and catheterization results were normal. The athlete later received an ICD and pacemaker, prompting significant physical, emotional, and lifestyle adjustments. This capstone project examines the emergency response, the role of trained medical personnel at sporting events, and the implications of early cardiac screening for adolescent athletes. Through consented family interviews, structured questionnaires, and case-based data collection, the …

Longitudinal Fueling Status Of High School Female Athletes, Kaylee Turner, Abigail Rickermann

2026 Student Academic Showcase

Low energy availability (LEA) is a clinically significant concern in adolescent female athletes due to its impact on growth and development, bone health, hormonal function, performance, recovery, and cognitive outcomes. Despite established associations, a clear longitudinal understanding of how LEA relates to injury and illness rates across an academic year remains limited, representing a clinical gap in athletic training and sports medicine literature. The purpose of this capstone project was to develop a comprehensive Institutional Review Board (IRB) protocol to support a future longitudinal investigation examining LEA and its relationship to injury and illness incidence in high school female athletes. …

The Necessity Of Adaptive Sports: Addressing Financial Barriers To Participation In Children With Spinal Cord Injuries, Megan G. Wells

Student Capstone Papers

 Children with spinal cord injuries (SCIs) experience numerous barriers to participation in adaptive sports despite the well-established physical, psychosocial, and developmental benefits of physical activity. Financial constraints, limited awareness of funding opportunities, and the complexity of grant application processes often prevent families from accessing adaptive sports programs and specialized equipment. The purpose of this doctoral capstone project was to develop a comprehensive financial guidebook for families of children with SCIs to address financial barriers to adaptive sports participation, promote physical activity, and improve overall quality of life. Guided by the Person-Environment-Occupation-Performance (PEOP) model, this doctoral capstone project addressed financial accessibility …

Effectiveness Of Rule Modification And Contact Exposure Reduction In Adolescent Contact Sports, Alex Martin

2026 Student Academic Showcase

Clinical Question: In adolescent athletes participating in contact sports, does rule modification or contact restriction reduce sport-related concussion incidence compared with standard full-contact rules? Background: Sport-related concussion remains a major concern in youth athletics. Structural prevention strategies, such as limiting contact exposure, have been proposed as effective approaches, though their comparative effectiveness remains under review. Methods: A critically appraised topic (CAT) was conducted using Google Scholar to identify peer-reviewed studies from the past 15 years examining rule modification or contact restriction as primary prevention strategies. Six high-quality studies met inclusion criteria, including one meta-analysis, one systematic review, prospective cohort studies, …

Understanding The Impact Of Therapeutic Recreation On Patient Outcomes, Faith Atkins, Emma Jones

2026 Student Academic Showcase

This exploratory project examines the role of Therapeutic Recreation (TR) in improving overall well-being and quality of life for individuals across diverse populations. The purpose of this project is to analyze how leisure-based interventions can be adapted to meet the physical, cognitive, emotional, and social needs of patients in various settings. By synthesizing current research and professional practices, this project highlights how TR contributes to rehabilitation, identity rebuilding, and long-term wellness. The project focuses on how recreational therapists use individualized, evidence-based approaches to help patients re-engage in meaningful activities following injury, illness, or disability. It also explores the impact of …

Clinical Evaluation And Rehabilitation Of A Complex Non-Contact Knee Injury In A Collegiate Athlete, Shelby Pritt

2026 Student Academic Showcase

This case follows the rehabilitation of a 22-year-old collegiate lacrosse player recovering from a complex knee injury. During the initial evaluation, the athlete presented with pain, swelling, and limited active range of motion, secondary to pain. The rehabilitation protocol used a combination of ACL, MCL, and meniscus standardized rehabilitation parameters. The primary goal of rehabilitation was to safely return the athlete play the following season. This case highlights the importance of knee health and the role of preventative exercise programs in reducing injury risks. This case covers the rehabilitation of a complex right knee injury primarily focusing on a complete …

Fitness For All: Education For Gym Staff Supporting People With Disabilites, Bianca Loor, Mary Jan Greer, Alison Skean

Spring 2026 OTD Capstone Symposium

This capstone project, “Fitness for All: Education for Gym Staff Supporting People with Disabilities,” focuses on improving accessibility and inclusion within community fitness settings through staff education. Individuals with disabilities often encounter barriers in gyms due to limited staff training, lack of confidence, and insufficient knowledge of adaptive fitness practices.

To address this gap, a comprehensive, evidence-based training program was developed and implemented for gym staff at Crunch Fitness Orange Park. The program incorporated occupational therapy frameworks, including the Person-Environment-Occupation (PEO) model and the Occupational Therapy Practice Framework (OTPF-4), to promote inclusive and client-centered fitness practices.

Using a mixed-methods approach, …

Sensory-Friendly Environments In Schools, Jocelyn A. Ashworth, Rebecca King

Spring 2026 OTD Capstone Symposium

Sensory-Friendly Environments in Schools focuses on strengthening sensory-motor lab use and building educator understanding to support students with sensory processing difficulties. Implemented at Sparta Elementary School within Belton ISD, with the goal to enhance students' regulation, attention, and participation in daily school activities by equipping educators with practical, sustainable sensory strategies.

Project Evaluation Of A Workplace Violence Prevention Program At A Rural Hospital, Stacy Ochoa-Sofoifa, Yolanda L. Rodriquez, Melissa Bowe, Teresa Mendoza

Publications 2026-present

No abstract provided.

Family-Based Gwas Of Cognitive Endophenotypes Reveals Genetic Architecture Of Memory And Executive Function In Alzheimer’S Disease, Kesheng Wang, Xueying Yang, Gayenell Magwood, Chun Xu, R. Osvaldo Navia, Jean Neils-Strunjas, Xiaoming Li

Health & Biomedical Sciences Faculty Publications

Alzheimer’s disease (AD), the most common cause of dementia, is characterized by progressive memory and cognitive decline. Conventional genome-wide association studies (GWAS) comparing AD cases and controls may miss genetic influences that act along a continuum of cognitive function. Using data from 3007 participants in the National Institute on Aging Late-Onset Alzheimer’s Disease Family Study (NIA-LOAD GWAS), we conducted a family-based GWAS of eight quantitative cognitive phenotypes encompassing episodic memory (Logical Memory IA and IIA), working memory (Digit Span Forward, Backward, and Ordering), and semantic fluency (Animal, Fruit and Vegetable, and Vegetable Fluency). Family-based association testing in PLINK v1.9 identified …