Digital Commons Network^™

Differences In Injury Rates By Competition Level Among Scholastic And Collegiate Female Lacrosse Athletes: A Systematic Review, Carrie J Froemming, Daniel C Touhey, Robert H Brophy, Derrick M Knapik

2020-Current year OA Pubs

BACKGROUND: Women's lacrosse is an increasingly popular sport. Current rules allow incidental body and stick-to-stick contact, with limited required protective equipment. Injuries to the head, face, and lower extremities are common, especially at higher levels of competition. Differences in injury rates and types based on competition level remain largely unknown.

PURPOSE: To systematically review the literature to better understand injury differences between scholastic and collegiate female lacrosse athletes.

STUDY DESIGN: Systematic review; Level of evidence, 4.

METHODS: Under PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-analyses), 543 studies were identified in September 2025 in PubMed, Scopus, Google Scholar, …

Best Practice: Ct-Guided Adaptive Radiotherapy Reference Planning On The Ethos Platform, Xenia Ray, Joseph Harms, Alex Price, Mu-Han Lin, Dennis N Stanley

2020-Current year OA Pubs

Online adaptive radiotherapy (ART) enables treatment plan modifications based on the patient's anatomy at each fraction, addressing limitations of conventional radiotherapy that relies on a static pre-treatment plan. CT-guided ART (CTgART), as implemented on the Varian Ethos platform, has gained increased clinical adoption over the past several years; however, its success is highly dependent on reference plan design due to limited on-table planning flexibility. As a result, clinicians creating and reviewing reference plans will greatly benefit from both understanding how upstream planning decisions affect the downstream adaptive process and proactively incorporating strategies that improve optimization robustness and efficiency on-treatment. We …

Multicenter Comparison Of Modern Plating Options In Fibula, Scapula, And Osteocutaneous Radial Forearm Free Flaps, Craig A Bollig, Amit Walia, Patrik J Pipkorn, Ryan S Jackson, Sidharth V Puram, Jason T Rich, Randal C Paniello, Et Al.

2020-Current year OA Pubs

OBJECTIVES: Evaluate the association of plating strategies with hardware removal and operative time, after adjusting for relevant clinical variables.

STUDY DESIGN: Retrospective Review.

SETTING: Multiple Academic Medical Centers.

METHODS: Patients undergoing osseous free flap reconstruction stratified based on the plating strategy [conventional plating with a hand-bent plate, precontoured plate, and virtual surgical planning (VSP) with patient-specific hardware and cutting guides]. Variables associated with hardware removal were analyzed using multivariable logistic regression. To evaluate the effect of plating strategy on operative time, a multivariable linear regression model was created. Adjusted odds ratios (aOR) with 95% confidence intervals (CI) were calculated.

RESULTS: …

Navigating The Shift: Supporting Health Sciences Faculty Transitioning From Industry To Asynchronous Online Education, Joshua D. Snyder

Electronic Theses and Dissertations

This qualitative exploratory study examined how new online instructors in the health sciences division of a North Texas community college experienced institutional onboarding and professional development as they transitioned from industry roles into asynchronous online teaching. As community colleges expand online instruction to meet the needs of nontraditional learners, many health sciences faculty enter academic roles with strong clinical expertise but limited preparation in online pedagogy. Guided by the community of inquiry framework and self-efficacy theory, this study explored instructors’ perceptions of their preparedness for asynchronous teaching; the instructional challenges they encountered, particularly related to student engagement; and the types …

Ai-Powered Insights In Pediatric Nephrology: Current Applications And Future Opportunities., Arwa Nada, Yamen Ahmed, Jieji Hu, Darcy K. Weidemann, Gregory H. Gorman, Eva Glenn Lecea, Ibrahim A. Sandokji, Stephen Cha, Stella Shin, Salar Bani-Hani, Sai Sudha Mannemuddhu, Rebecca L. Ruebner, Aadil Kakajiwala, Rupesh Raina, Roshan George, Rim Elchaki, Michael L. Moritz, The American Society Of Pediatric Nephrology Quality Improvement And Artificial Intelligence (Aspn Qi/Ai) Interest Group

Manuscripts, Articles, Book Chapters and Other Papers

Artificial intelligence (AI) is rapidly emerging as a transformative force in pediatric nephrology, enabling improvements in diagnostic accuracy, therapeutic precision, and operational workflows. By integrating diverse datasets-including patient histories, genomics, imaging, and longitudinal clinical records-AI-driven tools can detect subtle kidney anomalies, predict acute kidney injury, and forecast disease progression. Deep learning models, for instance, have demonstrated the potential to enhance ultrasound interpretations, refine kidney biopsy assessments, and streamline pathology evaluations. Coupled with robust decision support systems, these innovations also optimize medication dosing and dialysis regimens, ultimately improving patient outcomes. AI-powered chatbots hold promise for improving patient engagement and adherence, while …

Regional Variation Of Underlying Kidney Diseases In Children Undergoing Chronic Kidney Replacement Therapy Around The Globe., Dagmara Borzych-Dużałka, Marjolein Bonthuis, Uma Ali, Yok-Chin Yap, Michael Manno, Yihui Zhai, Reyner Loza, Seema Hashmi, Naye Choi, Kenza Soulami, Judith Exantus, Mohamed S. Al Riyami, Sameh Mabrouk, Marbella Ma Angeles, Cristina Zelaya-Camacho, Henny Adriani Puspitasari, Syed Saimul Huque, Francisco Cano, Kar Hui Ng, Sevcan A. Bakkaloğlu, Jerome Harambat, Kitty J. Jager, Bradley A. Warady, Franz Schaefer

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: There is a scarcity of information regarding the distribution of the diseases leading to kidney failure (KF) in children living in the emerging world. We used registry data to provide a global overview of the underlying disease spectrum in children commencing kidney replacement therapy (KRT).

METHODS: We analyzed KF causes among 23,620 children and adolescents commencing maintenance KRT in 80 countries, using data from the IPNA Global KRT Registry (including ESPN/ERA Registry), the International Pediatric Dialysis Network (IPDN), the United States Renal Data System (USRDS), and the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA). The analysis considered …

Barriers To Climate Change And Sustainability Action: Nursing Education And Practice, Dawn Marie Smith

Dissertations

Climate change is one of the most pressing public health emergencies of our time and nurses can have a great impact in their current practice and in the education of future nurses (The Alliance of Nurses for Healthy Environments, n.d.; American Nurses Association, 2023; Health Care without Harm, 2025). Deaths due to rising temperatures, vector-borne illness, and food insecurity related to drought and extreme weather are on the rise (WHO, 2024). It has been estimated that globally over 250,000 additional deaths will be attributed to climate related effects between 2030 and 2050 (Watts et al., 2020; WHO, 2023).

A primary …

Convergence And Divergence Of Opinion About Treatment Of Binocular Vision Disorders Among Vision Care Professionals, Sonia Young

Dissertations

There are three distinct professions prominent in the field of pediatric vision care. They are ophthalmology, optometry and orthoptics. All professions are integral to the detection and treatment of pediatric binocular vision disorders. However, distinct schools of thought exist to describe the best approach to pediatric binocular vision disorders and their treatments. Literature often highlights two opposing schools of thought represented by the “medical” and “behavioral” approaches. While there is academic debate about the merits and pitfalls of either approach, there is a paucity of nuanced perspectives which more closely resemble the ways in which pediatric ocular clinicians approach diagnosis …

Leading With Hope: A Clinical Communication Campaign To Promote Partner Hiv Testing In Assisted Partner Notification And Antenatal Care Programs In Uganda., Emily A. Hurley, Violet Gwokyala, Linda Kisaakye Nabitaka, Jolly Beyeza Kashesya, Mercylynn Agasha, Florence Namaganda, Nikolaus Schuetz, J Nalubega Ross, Joseph K B Matovu, Rhoda Wanyenze, Glenn Wagner, Kathy Goggin

Manuscripts, Articles, Book Chapters and Other Papers

Among heterosexual couples in sub-Saharan Africa, fears of relationship dissolution and inability to bear healthy children following an HIV-positive result remain barriers to HIV testing. Recently expanded availability of pre-exposure prophylaxis (PrEP) affords a critical opportunity to promote HIV testing with reassuring communication that highlights use for relationship preservation and healthy childbearing. We aimed to develop a theoretically-grounded communication intervention to promote partner HIV testing within assisted partner notification (APN) and antenatal care (ANC) programs in Uganda. Through an 18-month iterative co-creation process, we developed the HOPE Clinical Communication Campaign (HOPE-CCC) in collaboration with a project advisory board (PAB) of …

Promises, Pitfalls, And Paths Forward For The Pediatric Research Equity Act., Alexa L. Pagano, Danielle J. Green, Jennifer Goldman, Anjali Deshmukh

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Since its enactment in 2003, the Pediatric Research Equity Act (PREA) has significantly increased the number of pediatric drug studies performed and expanded pediatric drug labeling. Despite these advancements, many drugs used in children still lack pediatric-specific US Food and Drug Administration (FDA) labeling, even when pediatric studies are required by law. Recent legislative changes strengthened the FDA's enforcement authority over PREA. As these changes are implemented, persistent gaps in pediatric drug development warrant examination. Addressing these gaps may help ensure that children are systematically included in clinical research and that medications used in children are supported by rigorous …

American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy., Daniel Freedman, Ifeoluwa Babatunde, Rebecca L. Morgan, Renad Abu-Sawwa, Dara Albert, Mandana Behbahani, Kevin Chapman, Erin Day Fecske, William Davis Gaillard, Monika Jones, Mary Anne Meskis, Leah Schust Myers, Kim Nye, Chima Oluigbo, Heidi H. Pfeifer, Reneé A. Shellhaas, Lindsey Thompson, Howard L. Weiner, Courtney J. Wusthoff, Elissa Yozawitz

Manuscripts, Articles, Book Chapters and Other Papers

This practice guideline from the American Epilepsy Society provides evidence-based recommendations for pharmacological, dietary, and surgical therapies for epilepsy for infants and children from 1 month of age to < 36 months. The multidisciplinary panel updated an existing systematic review, which was funded by the Patient-Centered Outcomes Research Institute and conducted by ECRI (formerly the Emergency Care Research Institute) on behalf of the Agency for Healthcare Research and Quality. The updated review used the same search strategy, inclusion/exclusion criteria, and Grading of Recommendations Assessment, Development and Education methodology, and added studies from August 2021 through September 2025 that were not in the original systematic review. As with the previous review, West syndrome and infantile spasms were excluded from this guideline, as existing treatment guidance is already available for infantile epileptic spasms. While many of the recommendations are conditional due to low certainty of evidence, the panel made two strong recommendations: (1) hemispherectomy/hemispherotomy surgery is recommended for infants and children < 36 months of age with drug resistant epilepsy secondary to select underlying lesional pathologies, including but not limited to hemimegaloencephaly, Rasmussen's encephalitis, Sturge-Weber syndrome, perinatal stroke, and hemispheric cortical dysplasia; and (2) intralobar, multilobar, or focal resections or posterior disconnections for drug-resistant focal or lesional epilepsy in this same age range. A treatment algorithm was developed based on evidence and expert opinion as part of the guideline to help place pharmacological, dietary, and surgical recommendations in a clinical context. The limited number of studies and low certainty of evidence in this population underscores the need for higher-quality data and etiology-specific treatments. More research is needed to evaluate effective therapies for infants with epilepsy, as well as the impact these therapies have on long-term developmental and mortality outcomes.

Accelerated Weaning Of Opioids To Reduce Pharmacologic Exposure For Neonatal Opioid Withdrawal Syndrome: A Randomized Clinical Trial., Abbot R. Laptook, Adam Czynski, Rouba Chahine, Rachel G. Greenberg, P Brian Smith, Erica Oliveira, Jenna Gabrio, Barry Eggleston, Abhik Das, Jeannette Lee, Barry Lester, Dave Clark, Michele Walsh, Helen Ko, Clare Campbell Asher, Hayley Friedman, Samuel Gentle, Karishma Rao, Anup Katheria, Kristen Benninger, Sanket Jani, Mark Cody Smith, Akram Khan, Ajay Talati, Shaina Lodhi, Fernando Mena, Amanda England, Prabhu Parimi, Ranjit Kylat, Heidi Harmon, Javed Mannan, Meghan P. Howell, Tanner Wright, Jessica Snowden, Act Now Collaborative

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To determine if newborns receiving morphine or methadone as the primary pharmacologic treatment for neonatal opioid withdrawal syndrome (NOWS) tolerate and receive fewer days of opioid using an accelerated wean protocol (15% decrements) compared with using a slower wean protocol (10% decrements).

STUDY DESIGN: Newborns ≥36 weeks of gestation receiving morphine or methadone for NOWS were enrolled in a pragmatic blinded, randomized multicenter trial. Newborns underwent protocol-driven weaning with decreasing opioid doses of either 15% or 10% decrements. Weaning was encouraged every 24 hours, and if signs of NOWS worsened, the preceding dose was resumed. To maintain blinding, the …

Natural Maternal Immunity Protects Neonates From Escherichia Coli Sepsis., Raymond E. Diep, Ujjwal Adhikari, Kubra Gokce Tezel, Giang Pham, Allison R. Burrell, Mary A. Staat, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Kate M. Peters, Mark A. Schembri, Scott H. Saunders, David B. Haslam, John J. Erickson, Susana Chavez-Bueno, Sing Sing Way

Manuscripts, Articles, Book Chapters and Other Papers

Escherichia coli is a leading cause of neonatal sepsis, with infection occurring in approximately one in every 1,000 live births. However, with E. coli colonization beginning soon after birth and defects in neonatal host defence maturation, an alternative consideration is why infection does not occur even more frequently. Here we show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli, mechanistically explaining their susceptibility to infection. Complementary preclinical studies show that preconceptual intestinal colonization with probiotic E. coli Nissle 1917 (EcN) primes anti-E. coli immunoglobulin G (IgG) antibodies with broad cross-reactivity …

Consensus Guidelines On Inferior Petrosal Sinus Sampling: A Guideline From The Society Of Vascular And Interventional Neurology Guidelines And Practice Standards Committee, Farhan Siddiq, Hunter Brooks, Esra Demirtas, Ibrahim Ahmad Bhatti, Sami Al Kasab, Adam De Havenon, Robin Novakovic, Ossama Y. Mansour, Cynthia L. Kenmuir, Ameer E. Hassan

School of Medicine Publications

Background: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold-standard test to distinguish Cushing disease (CD) from ectopic adrenocorticotropic hormone (ACTH) secretion when biochemistry confirms ACTH-dependent Cushing syndrome and pituitary magnetic resonance imaging is equivocal. However, practice varies widely between centers, leading to false negatives, misinterpretation, sampling errors, and avoidable risk. Neurointerventionalists performing BIPSS have lacked dedicated, procedure-focused guidance.

Methods: Using the Society of Vascular and Interventional Neurology Guidelines and Practice Standards framework, a multidisciplinary panel (endocrinology, interventional neuroradiology, and endovascular neurosurgery) performed a systematic review through August 2025 and developed recommendations graded by class of recommendation and level of …

Clinical Characteristics, Antibiotic Resistance Trends, And Associated Molecular Epidemiology Traits In Escherichia Coli Isolates Producing Neonatal Bacteremia, Keerti Ivaturi, Christine Symes, Mina Farahbakhsh, Sanjula Bhuri, Joshua L Wheatley, Rangaraj Selvarangan, Daniel P. Heruth, Susana Chavez-Bueno

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Escherichia coli is a leading cause of neonatal sepsis. This study's objective was to investigate the clinical characteristics of newborns with E. coli bacteremia, and recent antibiotic resistance trends and molecular epidemiologic features of these invasive strains.

METHODS: Clinical data and blood E. coli isolates collected from 54 neonates with bacteremia were studied. E. coli antibiotic susceptibility trends over time, and whole-genome sequencing data relevant to the genomic relatedness and capsule genotype of the isolates were analyzed.

RESULTS: Thirty percent of bacteremic newborns were preterm. Mortality was 19% in preterm versus 5% in term infants. Cerebrospinal fluid was collected …

Detecting Early Physiological Signs Of Work-Related Muscle Strain And Fatigue Using Quantitative Sensory Testing, Omar Alberto Cano

Open Access Theses & Dissertations

Background: Work-related musculoskeletal disorders (WRMSDs) are a major source of occupational disability and economic burden worldwide. Early detection of physiological strain remains challenging since traditional methods often rely on self-reported pain or diagnosis after symptom development. Quantitative Sensory Testing (QST) may provide an objective, non-invasive method for identifying early sensory changes associated with repetitive upper-extremity loading. Purpose: This pilot study examined the responsiveness of Pressure Pain Threshold (PPT) and Thermal Threshold Testing (TTT) for detecting Acute muscular strain and fatigue following repetitive manual task performance. Methods: A within-subject counterbalanced design was conducted with sixteen healthy participants. Each participant completed both …

Health Disparities In El Paso's Low-Income Hispanic Communities: A Mixed-Methods Analysis Of Acculturation, Obesity Metrics, And Socio-Cultural Determinants, Karen Del Rio

Open Access Theses & Dissertations

Health disparities among low-income Hispanic immigrants in the United States are shaped by complex interactions between acculturation, structural inequality, and socio-cultural determinants that behavioral and epidemiological models have not fully explained. This dissertation examines the relationship between acculturation and obesity-related outcomes among uninsured and low-income Hispanic adults of Mexican descent in El Paso, Texas, using a three-article, sequential, explanatory, mixed-methods design grounded in Latina/o Critical Race Theory (LatCrit).Article 1 presents a systematic review of 20 peer-reviewed studies examining acculturation and obesity among Mexican Americans, finding consistent evidence that longer U.S. residence is associated with increased BMI and obesity prevalence, mediated …

Prediabetes Prediction Before Disease Onset Using Multimodal Health Data: A Machine Learning Approach, Luisa Veronica Gracia Mazuca

Open Access Theses & Dissertations

Prediabetes is a critical health condition that increases the risk of developing type 2 diabetes. The hemoglobin A1c (HbA1c) test diagnoses patients with prediabetes, but the disease has already caused metabolic alterations. Early detection is essential for timely interventions, and machine learning models offer a promising approach to identify prediabetic individuals through the analysis of biomarkers such as cytokines. We compared four classifiers-logistic regression, decision tree, random forest, and k-nearest neighbors - using cytokines (TNF-α, MCP-1, IL-1β, IL-6, IFN-γ), age, BMI, and waist-to-hip ratio (WHR). Models were evaluated using stratified 5-fold cross-validation and ROC-AUC. K-Nearest Neighbors (k-NN) achieved the highest …

Exploratory Proxy Occupational Health Risk Assessment On Pm2.5 Exposure Among Outdoor Personnel At International Ports Of Entry, Josdell Maria Guerra Ruiz

Open Access Theses & Dissertations

Despite growing public health concerns on PM2.5 exposure and its respiratory health effects, no documented evidence has been found on the application of proxy methods to perform occupational health risk assessments for PM2.5 exposure among outdoor personnel. The purpose of this research study was to conduct a descriptive and predictive occupational health risk assessment for cancer and non-cancer respiratory health outcomes related to PM2.5 exposure among outdoor personnel at targeted international ports of entry (IPOE). A total of 61 samples were collected, for 24 hours, at two targeted IPOEs (every sixth day) over 12-month period. Samples included measurements on PM2.5 …

Voices Of Men In Diabetes Care: Evaluating Participant Satisfaction With A Men's Diabetes Management And Self-Care Program, Elida Herrera

Open Access Theses & Dissertations

Background: Hispanic populations in the US experience higher diabetes prevalence, yet Hispanic men participate in traditional diabetes education programs at lower rates than non-Hispanic White men and Hispanic women, in part because existing programs lack cultural and gender-relevant tailoring. To address this disparity, the Diabetes Garage (DG) program was developed for Hispanic men in Southwest Texas, leveraging car culture by using automotive maintenance analogies to illustrate diabetes self-management concepts to engage men. Purpose: To evaluate participant satisfaction with the DG program among cohorts participating across three predominantly Hispanic communities and to examine their personal opinions on their program experience. Methods: …

Human Papillomavirus (Hpv) Vaccine Acceptance: A Mixed-Methods Study And Randomized Controlled Trial Examining Messengers Of Hpv Vaccine Information Among Hispanic Parents, Alyssa Andrea Martinez

Open Access Theses & Dissertations

Hispanics make up 19.5% of the U.S. population, making them the nation's largest ethnic minority. Hispanics are disproportionately impacted by health outcomes, including many different types of cancers that are caused by the Human Papillomavirus (HPV). An HPV vaccine is available that can prevent 90% of HPV associated cancers. The purpose of this mixed-methods study and randomized experiment is to develop and test data-driven digital health messages to promote the HPV vaccine in Hispanic parents. Four specific aims were conducted among three major studies. Aim 1 (Study 1): A cross-sectional survey was conducted to obtain preliminary evidence on trusted messengers …

Adverse Childhood Experiences, Resilience, And Adaptive Functioning Among Student Veterans With Disabilities. A Resilience Portfolio Model Perspective, Donyeill Mozer

Open Access Theses & Dissertations

Adverse Childhood Experiences (ACEs) are associated with long-term psychological, physical, and behavioral outcomes; however, limited research has examined their relationship with multidimensional college adjustment among student veterans with disabilities, particularly those attending Hispanic-Serving Institutions (HSIs). Guided by the Resilience Portfolio Model, this study examined associations among ACEs, perceived resilience, and multidimensional college adjustment within an understudied population of student veterans with disabilities enrolled at an HSI. Using a cross-sectional secondary analysis of survey data, the analytic sample consisted of 129 student veterans. ACEs were measured using the Adverse Childhood Experiences Questionnaire, perceived resilience was measured using the Brief Resilience Scale, …

Implementing Mtss In Hispanic Serving Middle Schools From The Concept Of Rurality: A Qualitative Case Study On School Mental Health And The Role Of Social Work, Rosario Elena Olivera

Open Access Theses & Dissertations

Purpose: The purpose of this study was to examine the implementation of Multi-Tiered Systems of Support (MTSS) and the integration of mental health services within two middle schools in a suburban-rural mix, predominantly Hispanic school district in Southwest Texas, referred to as Desert View Independent School District. The study explored how educators and school-based mental health professionals perceive, interpret, and operationalize MTSS within their school contexts. Methods: The study employed a qualitative case study design grounded in implementation science and ecological systems theory. Data were collected through purposive sampling and included semi-structured interviews with teachers, counselors, and a district-level school …

Enhancing Gender Congruence And Life Satisfaction In The Borderland Through Gender-Affirming Communication Services, Kimberley Ramirez

Open Access Theses & Dissertations

Transgender individuals frequently encounter barriers to accessing gender-affirming healthcare, particularly within marginalized borderland communities. Communication-based gender affirmation, including voice therapy and nonverbal communication training, remains an underexplored yet essential component of transgender health and psychosocial well-being. The purpose of this study was to examine the impact of gender-affirming communication services on voice-gender congruence and life satisfaction among transgender individuals living in the U.S.-Mexico borderland region. A single-subject experimental design (ABAB) was implemented with six participants initially enrolled in the study. Four participants completed all intervention phases and were included in final analysis. Intervention consisted of individualized gender-affirming communication services targeting …

Caregiver Experiences During Mealtime In Families Of Children With Feeding Disorders In The Borderland, Chyanne Reveles

Open Access Theses & Dissertations

This study examines the lived experiences of caregivers of children with pediatric feeding disorders (PFDs) in the Paso del Norte Region using interpretative phenomenological analysis (IPA). Pediatric feeding disorders require sustained medical, social, and emotional demand, often placing caregivers in complex decision-making roles. Understanding how cultural beliefs and context shape caregiving practices is essential to improving services provided by speech-language pathologists and other service providers. The qualitative research approach used facilitated the discovery of themes surrounding the lived experience of the caregivers of children with feeding disorders. Semi-structured interviews were conducted via Zoom with caregivers residing in the U.S.-Mexico border …

Determining Zap-70 Signaling Pathways Mediated By Ccr7 In Tcr T Cell Activation, Vivian Torres

Open Access Theses & Dissertations

Activation of T lymphocytes is the main event that occurs in the adaptive immune response after engagement of the T cell receptor (TCR) with the peptide of the major histocompatibility complex (pMHC) molecules that are demonstrated by antigen presenting cells [1]. A key step in this process is the recruitment and activation of the zeta chain associated protein of 70 kDa (ZAP-70). ZAP-70 couples TCR engagement to downstream intracellular signaling pathways through phosphorylation of tyrosine residues within intracellular tyrosine activation motifs (ITAMs) [2]. Although there have been extensive studies on the signaling response through TCR activation, the regulatory influence of …

Molecular Mechanisms Of Pfas Induced Protein Dysfunction: Implications For Neurodegenerative Risk, Daisy Lee Wilson

Open Access Theses & Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread human exposure and well-established links to adverse health outcomes. However, despite increasing epidemiological and experimental evidence, the molecular mechanisms underlying PFAS-induced neurotoxicity remain incompletely defined. This dissertation investigates PFAS toxicity across biological scales, integrating protein biophysics with neuronal cell models to elucidate pathways relevant to neurodegeneration. At the molecular level, we demonstrate that PFAS disrupts the structure and function of globular proteins, including the impairment of α-lactalbumin's calcium-binding capacity and of β-lactoglobulin's retinol binding, through concentration-dependent conformational destabilization. By applying these findings to a neuronal model, we show that …

Show And Tell: Integrating The Arts Into Transdisciplinary Public Health And Community Organizing Education, Bree L. Hemingway, Margaret Hawkins

The Transdisciplinary STEAM+ Journal

This field note examines the integration of arts-based pedagogy into a transdisciplinary graduate course that brings together students from public health, medicine, the social sciences, humanities, education, technology, and the arts. Central to the course is the Show and Tell assignment, in which students select and present a work of art connected to a social movement. Over three years and 42 student submissions, this assignment has served as an accessible entry point for exploring how artistic expression shapes activism, fosters community, and deepens understanding of justice-oriented work. Through an inductive content analysis of student-selected artworks and presentations, five major thematic …

Measuring Time, Measuring Impact: Reimagining Protected Time In Graduate Medical Education, Rehan Qayyum

Eastern Virginia Medical Journal

This article does not have an Abstract.

Optimal Timing Of Coronary Artery Bypass Grafting In Patients With Nstemi – A National Study From The United States, Viet Nghi Tran, Hoang Nhat Pham, Ramzi Ibrahim, Hong Hieu Truong, Mahmoud Abdelnabi, Amreen Dhindsa, Pham Thao Vy Le, Doan Ngoc Chau Nguyen, Aisha Jamal, Phillip Tran, Thach Nguyen, Anwar Chahal, Kwan S. Lee, Reza Arsanjani, Amitoj Singh

Marshall Journal of Medicine

Background: The timing of coronary artery bypass grafting (CABG) in patients with non-ST-elevation myocardial infarction (NSTEMI) may critically impact clinical outcomes, yet the ideal surgical window remains unclear. We aimed to evaluate the association between time-to-CABG and in-hospital outcomes among NSTEMI admissions undergoing CABG.

Methods: This retrospective cohort study utilized the US National Inpatient Sample database from 2017 to 2021 to evaluate the association between time-to-CABG and key in-hospital outcomes, including mortality, cardiac arrest, cardiogenic shock, ischemic stroke, acute kidney injury, and blood transfusion rates, while assessing length of stay (LOS) and hospital charges exclusively among survivors. Adult admissions with …