Digital Commons Network^™

Multi-Scale Data Improves Performance Of Machine Learning Model For Long Covid Identification, Christopher Guardo, Zhang Xinmeng, Srushti Gangireddy, Yan Chao, V Eric Kerchberger, Alyson L Dickson, Emily R Pfaff, Hiral Master, Xin Yi, Melissa Basford, Christopher G Chute, Nguyen K Tran, Salvatore Mancuso, Toufeeq Ahmed Syed, Zhao Zhongming, Feng Qiping, Melissa Haendel, Christopher Lunt, Paul A Harris, Li Lang, Geoffrey S Ginsburg, Joshua C Denny, Dan M Roden, Wei Wei-Qi

Faculty, Staff and Student Publications

Background: Long COVID affects a substantial proportion of the over 778 million individuals infected with SARS-CoV-2, yet predictive models remain limited in scope. While existing efforts, such as the National COVID Cohort Collaborative (N3C), have leveraged electronic health record (EHR) data for risk prediction and identification, accumulating evidence points to additional contributions from social, behavioral, and genetic factors.

Methods: Using a diverse cohort of SARS-CoV-2-infected individuals (n > 17,200) from the NIH All of Us Research Program, we investigated whether integrating EHR data with survey-based and genomic information improves model performance.

Results: Our multi-scale approach outperforms EHR-only model's area under the …

Large-Scale Genetic Characterization Of Parkinson’S Disease In The African And African Admixed Populations, Fulya Akçimen, Kimberly Paquette, Peter Wild Crea, Kathryn Step, Emily Waldo, Mathew J Koretsky, Paula Saffie-Awad, Charles Achoru, Funmilola Taiwo, Simon Ozomma, Gerald Onwuegbuzie, Marzieh Khani, Spencer Grant, Lukman Owolabi, Chiamaka Okereke, Olajumoke Oshinaike, Emmanuel Iwuozo, Suleyman Can Akerman, Paul Suhwan Lee, Shyngle Oyakhire, Nosakhare Osemwegie, Kensuke Daida, Sani Abubakar, Adedunni Olusanya, Mariam Isayan, Christiane Alvarez, Rami Traurig, Adebimpe Ogunmodede, Sarah Samuel, Mary B Makarious, Fadimatu Sa'ad, Rashidat Olanigan, Kristin Levine, Ewere Marie Ogbimi, Dan Vitale, Francis Odiase, Francis Ojini, Olanike Odeniyi, Zih-Hua Fang, Nkechi Obianozie, Deborah A Hall, Ernest Nwazor, Tao Xie, Francesca Nwaokorie, Mahesh Padmanaban, Paul Nwani, Ejaz A Shamim, Alero Nnama, David Standaert, Morenikeji Komolafe, Marissa Dean, Godwin Osaigbovo, Elizabeth Disbrow, Ismaila Ishola, Ashley Rawls, Frank Imarhiagbe, Shivika Chandra, Cyril Erameh, Vanessa Hinson, Naomi Louie, Ahmed Idowu, J Solle, Scott A Norris, Abdullahi Ibrahim, Camilla Kilbane, Gauthaman Sukumar, Lisa M Shulman, Daniel Ezuduemoih, Julia Staisch, Sarah Breaux, Clifton Dalgard, Erin R Foster, Abiodun Bello, Andrew Ameri, Raquel Real, Erica Ikwenu, Huw R Morris, Roosevelt Anyanwu, Erin Furr Stimming, Kimberley Billingsley, Wemimo Alaofin, Pilar Alvarez Jerez, Osigwe Agabi, Dena G Hernandez, Rufus Akinyemi, Sampath Arepalli, Laksh Malik, Raymond Owolabi, Yakub Nyandaiti, Hampton L Leonard, Kolawole Wahab, Oladunni Abiodun, Carlos F Hernandez, Fatima Abdulai, Hirotaka Iwaki, Soraya Bardien, Christine Klein, John Hardy, Henry Houlden, Kamalini Ghosh Galvelis, Mike A Nalls, Nabila Dahodwala, Whitley Aamodt, Emily Hill, Alberto Espay, Stewart Factor, Chantale Branson, Cornelis Blauwendraat, Andrew B Singleton, Oluwadamilola Ojo, Lana M Chahine, Njideka Okubadejo, Sara Bandres-Ciga

Faculty, Staff and Student Publications

Elucidating the genetic contributions to Parkinson's disease aetiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest sequencing characterization of potentially disease-causing, protein-altering and splicing mutations in 710 cases and 11 827 controls from genetically predicted African or African admixed ancestries. We explored copy number variants (CNVs) and runs of homozygosity in prioritized early onset and familial cases. Our study identified rare GBA1 coding variants to be the most frequent mutations among patients with Parkinson's disease, with a frequency of 4% in our case cohort. Of the 18 …

Improving Nursing Orientation: A Preceptor-Led Competency Program, Brandy Tanesa Broadway

Walden Dissertations and Doctoral Studies

No abstract provided.

Small Partial Deletion Of A Highly Gc-Rich Foxf1 Exon 1 In Two Deceased Siblings With Alveolar Capillary Dysplasia, Hiuling Chan Joiner, Shruti A Pande, Przemyslaw Szafranski, Partha Sen, Gail Deutsch, Pawel Stankiewicz

Faculty, Staff and Students Publications

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare lethal lung developmental disorder caused by haploinsufficiency of FOXF1. While larger-sized coding and noncoding copy-number variant (CNV) deletions involving the FOXF1 locus are detected in approximately half of histopathologically-diagnosed ACDMPV patients, small CNVs remain diagnostically challenging. Here, we revisited an unsolved case of familial ACDMPV with two affected siblings. Whole genome sequencing (WGS) of 30-year-old archival lung autopsy tissue analyzed using AI powered platform revealed a 151 bp CNV deletion involving a highly GC-rich portion of exon 1 of FOXF1 that was not detected using Sanger sequencing and …

Apathy, Effort-Based Decisions And Brain Integrity In Alzheimer’S And Parkinson’S Diseases, Lee-Anne Morris, Hideo Suzuki, Seonjoo Lee, Zekai Jin, Bryan B Chen, Ana Marin, Edward D Huey, Yunglin Gazes, Sarah R Heilbronner, Campbell J Le Heron, Nora Vanegas-Arroyave

Faculty, Staff and Students Publications

Apathy, or loss of motivation, is a prominent syndrome accompanying both Alzheimer's and Parkinson's diseases, in addition to other disorders. One approach to understanding motivational loss is to examine the processes underlying goal-directed behaviour. Weighing up rewarding outcomes against the effort costs required to obtain them (effort-based decision-making) is a core computation when deciding to act for outcomes. Although a growing body of evidence points to disruption of this computation in people with apathy, which underlying decision parameters drive this disruption, their neural associations and whether these would generalize or differ across brain disorders have not been examined. People with …

Timing Isn't Everything: Rethinking Mortality Risk In Type A Aortic Dissection Surgery, Anna H Xue, Joseph S Coselli

Faculty, Staff and Students Publications

No abstract provided.

Purine Metabolic Adaptation Protects The Endothelium From Disturbed Flow-Induced Dna Damage And Atherosclerosis, Qian Ma, Yongfeng Cai, Zhidan Zhang, Dingwei Zhao, Yuan Zhao, Peishan Xu, Tammy Lu, Wendy Zhang, Qiuhua Yang, Yaqi Zhou, Varadarajan Sudhahar, Tohru Fukai, Hanjoong Jo, Yiming Xu, Yuqing Huo

Faculty, Staff and Students Publications

Despite effective lipid-lowering therapies, atherosclerosis continues to be a leading cause of death, with considerable residual cardiovascular risk. Atherosclerotic lesions develop preferentially at arterial regions exposed to disturbed flow (d-flow), which induces genomic stress, endothelial injury, and barrier dysfunction. Hemodynamic forces are known to reprogram endothelial metabolism, but the role of de novo purine synthesis (DNPS), which supplies nucleotides for genome maintenance and whose terminal steps are catalyzed by the bifunctional enzyme ATIC, remains undefined in atherosclerosis. By integrating bulk and single-cell multiomics with in vitro flow systems and in vivo models, we show that d-flow upregulates DNPS and ATIC …

Transcriptome Predictors Of Second Breast Events In Ductal Carcinoma In Situ: A Case‒Control Study Including Black And White Women, Aditi Hazra, Emma Berdan, Thomas Walsh, Sarah Humble, Jen Tappenden, Katherine Deschryver, Deborah Veis, Kiran Vij, Shannan Ho Sui, Graham A Colditz

2020-Current year OA Pubs

BACKGROUND: Black women diagnosed with ductal carcinoma in situ (DCIS) experience disproportionately higher risk of second breast cancer events (SBEs), including both ipsilateral and contralateral recurrences, yet remain underrepresented in molecular biomarker studies compared to non-Hispanic White women.

METHODS: We performed RNA sequencing on 200 archival DCIS samples from the Resource of Archival Breast Tissue cohort, including 33% self-reported Black women. We correlated transcriptomic and clinical data to identify predictors of SBEs. Cases (n = 100) who developed SBEs between 1999 and 2019 were matched 1:1 to controls (n = 100) on age, race, and margin status, who remained event-free …

Emerging Near-Infrared Targeted Imaging Pharmaceutics For Ovarian Cancer, Angel J. Phillip, Annu Karithara, Subhash Chauhan, Murali Yallapu

School of Medicine Publications

Background: Accurate intraoperative identification of ovarian cancer is challenging, as standard techniques such as visual inspection, palpation, and histopathology often fail to detect microscopic disease. Residual tumor contributes to poor cytoreductive outcomes, high recurrence rates, and chemoresistance. Near-infrared (NIR) imaging using tumor-specific biomarkers has emerged as a promising approach to enhance intraoperative visualization and improve tumor margin delineation. Methods: A focused literature review was conducted using PubMed to identify preclinical and clinical studies evaluating NIR image-guided strategies in ovarian cancer. Studies involving tumor-targeted probes against folate receptor alpha, α3-integrin, mesothelin, and CA125 were included, with emphasis on probe design, delivery, …

Impact Of Intravenous Thrombolysis On Aspiration Thrombectomy Outcomes: An Imperative Trial Subgroup Analysis, Maxim Mokin, Reade Andrew De Leacy, William Mack, Raul G. Nogueira, Shahram Majidi, Dana Tomalty, Jan Vargas, Brett L. Cucchiara, Kenneth V. Snyder, Victoria Parada

School of Medicine Publications

Background The impact of intravenous (IV) thrombolysis on the outcomes of aspiration thrombectomy as the primary endovascular approach to stroke in patients with large vessel occlusion is unknown.

Methods The Imperative Trial was a prospective, investigational device exemption, multicenter trial of first-line aspiration thrombectomy that assessed the safety and efficacy of the Zoom System, including a novel 0.088 inch aspiration catheter in patients with stroke within 8 hours of onset. We compared procedural, technical, and clinical outcomes of aspiration thrombectomy based on whether patients had received IV thrombolytics prior to the intervention.

Results Among the 260 patients treated with front-line …

Blinded By Relapse: A Rare Case Of Bilateral Vision Loss From Leukemic Meningeal Infiltration, Aun A. Bangash, Tejaswini Swamy, Chloe C. Harris, Victoria Parada

Research Symposium

Background: Acute lymphoblastic leukemia (ALL) accounts for 20% of adult leukemias, with outcomes improving through modern systemic and CNS-directed therapies. Leukemic meningeal relapse, defined as infiltration of the meninges and detected by cerebrospinal fluid cytology, is reported in 4–7% of adult ALL patients and remains a devastating complication despite CNS prophylaxis. CNS involvement typically presents with nonspecific symptoms such as headache, nausea, or cranial neuropathies; isolated, abrupt vision loss is rare. With a median survival of less than six months if untreated, timely recognition is critical. We present a case of intracranial hypertension with bilateral vision loss due to leukemic …

Parenting Style And Academic Success: How Can You Help Your Child Succeed?, Elizabeth A. Weicker

Caravel Undergraduate Research Journal

The goal of this study was to investigate the relationship between the parenting style a college student experienced during childhood and the student’s most recent college GPA. Using survey data collected from undergraduate students throughout the United States, a between-subjects ANOVA was conducted to comparing different parenting styles and mean GPA for those styles. The parenting styles analyzed were authoritative, authoritarian, and permissive. Results indicated significant differences in GPA between parenting styles, with the authoritative parenting style producing the highest college GPA. In addition, an independent samples t-test was conducted to analyze the relationship between student satisfaction with the parenting …

The Role Of Paraprofessionals In The Mental Health Structure Of India, Amy Abraham, Kimberly D. Becker, Wendy Chu

Caravel Undergraduate Research Journal

The mental health treatment gap in India is part of a growing public health crisis, with over 95% of those in need of services never receiving them. Over 197 million Indians suffer from at least one diagnosable mental health disorder, and this number continues to grow given the treatment gap. The treatment gap is a result of four major factors: lack of government support, stigma, limited treatment facilities, and dearth of professionals able to provide treatment. The current study aimed to analyze several factors of paraprofessional-led mental health interventions including setting, treatments delivered, treatment models, and client outcomes. A narrative …

Searching For A Connection Between Intellectual Humility And Decision-Making Ability, Mansi Verma, Kristin Kirchner

Caravel Undergraduate Research Journal

The present study investigated whether there was a relationship between intellectual humility and decision-making. The participants were 32 undergraduate students recruited from the University of South Carolina. Data was collected through self-reported measures of intellectual humility from the participants and their answers to questions testing for decision-making ability in a single survey. Results indicate that there is a correlation between the scores on the Intellectual Humility Scale and CRT scores. Overall, there does appear to be a relationship between intellectual humility and decision-making.

Moving America: A Study Examining The Relationships Between Early Residential Mobility, Anxiety And Academic Performance, Kelsey Thomas, Wendy Chu, Melanie Palomares

Caravel Undergraduate Research Journal

Early residential mobility has known negative effects on mental health outcomes and academic achievement. These effects have been studied broadly and globally, yet there lacks attention in examining early residential mobility to specific localities, regions, or states. As such, this study sought to investigate these associations, specifically its impact on anxiety and academic performance in adults residing or living in South Carolina. Participants were surveyed online regarding their demographic information, academic performance, and anxiety levels. Results found no significant relationships between early residential mobility, anxiety, and academic performance among adults residing or living in South Carolina. Despite these null findings, …

College Student's Ideal Age For Having Children, Corrie Sanders, Melanie Palomares, Kristin Kirchner

Caravel Undergraduate Research Journal

It has been observed that women are beginning to have children at a later age than traditionally seen in history. This study examines college student’s ideal age for having children, and how it compares to the age of their mother when she had her first child. The data was collected mainly from undergraduate students at the University of South Carolina through a survey completed by 39 participants. Through a one-way between-subjects ANOVA, this study found there was not a significant difference of the ideal age to have children between college students ages 19, 20, 21, 22, and 23. The average …

Examining Biobehavioral Indicators Of Adhd In Children With Fxs, Hannah Pressler, Kayla Smith, Ramsey Coyle, Elizabeth Will, Jane E. Roberts

Caravel Undergraduate Research Journal

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and hyperactivity/impulsivity behaviors that are inconsistent with developmental age. Children with fragile X syndrome (FXS), a genetic neurodevelopmental disorder, are often diagnosed with comorbid ADHD (53–59% of males with FXS). Despite the prevalence of ADHD in FXS, little is known about the early manifestation of ADHD. The current project aims to explore group differences in play behaviors between children with FXS and typically developing (TD) children as well as the relationship between infant play behavior and heart activity to future ADHD attention outcomes. Participants included male children with FXS and …

Predator Or Prey: The Analysis Of Gender And Race On The Perception Of Black Men As Sexual Assault Victims, Jordyn Livingston, Dr. Florencia Cornet

Caravel Undergraduate Research Journal

Men sexual assault victims have gained more attention in recent years. Despite the growing sociological literature on violence against men, previous research provides little acknowledgment of Black men sexual assault victims. In this manuscript, I analyze emerging literature in the socio-medical sciences to explore how gender and race affects the perceptions of Black men as sexual assault victims. Specifically, I utilize intersectionality as a theoretical framework to synthesize literature on blackness and masculinity in sexual assault victims to conclude that there is an intersectional point that disadvantages Black males, portraying them as sexual predators. In so doing, I provide research …

Effect Of Ampk On Exercise-Induced Adipocyte Metabolism, Alec M. Giakas, Ran Hee Choi, Ho-Jin Koh

Caravel Undergraduate Research Journal

Regular physical activity is a recommended strategy to prevent obesity via increasing fatty acid metabolism. AMP-activated protein kinase (AMPK) has been associated with the activation of lipolysis in adipose tissue. Furthermore, it has been demonstrated that a single bout of exercise increases AMPK activity in adipocytes; however, the mechanism by which AMPK regulates exercise-induced adipocyte metabolism has yet to be determined. To examine the role of AMPK in exercise-induced adipocyte metabolism, we utilized fat-specific AMPK alpha 1 and alpha 2 knockout mice (FKO). Wild type (WT) and FKO mice were divided into sedentary (Sed) and exercise (EX) groups. After 6 …

The Effects Of Eating Disorder Knowledge On Dieting Beliefs, Kaitlyn Finn, Melanie Palomares, Kristin Kirchner

Caravel Undergraduate Research Journal

The study at hand was designed to look into the issues of eating disorder awareness and dieting attitudes. Specifically, it was hypothesized that individuals with more knowledge of eating disorders would be less likely to believe in dieting. It was additionally hypothesized that there would be a difference in amount of eating disorder knowledge seen between pre-determined age groupings. This was hypothesized due to the nature of the inception of eating disorders as a clinical diagnosis. Eating disorders did not begin to be added as a category into the Diagnostic and Statistical Manual until the 80’s, suggesting that participants of …

Predicting Narcissism Through Social Media, Cameryn Freglette, Melanie Palomares

Caravel Undergraduate Research Journal

The objective of this study was to assess if narcissism can be predicted through social media behaviors such as frequency of posts, posting selfies, and social media presence on a variety of platforms. This study was conducted through a questionnaire related to social media use and a brief assessment from the Narcissistic Personality Inventory (NPI- 16). Results indicated that social media use per day was significantly different between people who post selfies and those who do not. Participants that scored higher for narcissism used social media less but posted significantly more selfies. Results were not significant in predicting narcissism through …

Connecting On Campus: Exploring The Motivations And Behaviors Of College Students On Dating Apps, Emma Doyle, Melanie Palomares

Caravel Undergraduate Research Journal

Dating apps are increasingly popular among young people, including college students. However, these apps can be quite versatile, and there can be a number of reasons why a college student would use them, whether they are looking for a serious relationship, casual sex, or anything in between. Our study evaluated the intents, behaviors, and satisfaction of college students who used dating apps. Using Chi-Square and independent samples t-test analyses, results show that while satisfaction ratings were similar between men and women, more men use dating apps than women, which suggests that women might have a more negative perception of dating …

The Impact Of Weekly Workouts On Self-Reported Happiness Among College Students, Reid Davis, Melanie Palomares

Caravel Undergraduate Research Journal

College students are consistently at risk for depressive behaviors during a major time of habit transition (i.e., a time of gaining autonomy while developing their own lifestyle and health habits) and gaining in independence; this is met with only half of them not engaging in at least moderately vigorous exercise (Catellier 2013; Powell, 2019). The purpose of this study was to investigate the effects of types of exercise (cardio, weightlifting, and yoga/pilates) that undergraduate college students voluntarily engaged in on their subjective current and general happiness levels. There were 52 participants in the study, all undergraduates at the University of …

Changes In Medical Knowledge And Patent Medicine, Anna Mcnamee

Caravel Undergraduate Research Journal

This paper examines advertisements for patent medicines and nostrums, from the Colonial Period to the Food and Drug Act of 1906.  The Pure Food and Drug Act represented the triumph of the medical profession over state legislation and unsupervised patent medicine manufacturing. Tracing these advertisements alongside the historiography of science, medicine, and advertising; this paper argues that advertisements for patent medicine represent a shift in the culture of healing and the growth of medical knowledge in the United States. By the end of the nineteenth century, science and medicine made great advances and medical professionals began influencing both state and …

Evaluating The Role Of Stress, Self-Perceptions Of Health, And Self-Efficacy On Physical Activity Over Time: Results From Project Drive, Ashlynn Riley, Allison Sweeney, Dawn K. Wilson

Caravel Undergraduate Research Journal

Most Americans are not meeting the recommended levels of physical activity. In underserved communities, these inequities are even greater, with African American women being less likely to engage in physical activity and being at greater risk for chronic disease relative to non-minority women. This study seeks to further understand the factors that support or undermine engagement in physical activity among African American women. Specifically, the present study evaluates the impact of stress, self-perceptions of health, and self-efficacy on physical activity engagement in a 10-week physical activity intervention program for African American women. Participants (N = 33) completed measures of …

Dominance Linearity And Steepness In Captive Western Lowland Gorillas, Nate Wichmann

Caravel Undergraduate Research Journal

Many animals live in social groups for a variety of reasons, whether it is for hunting strategies, predator avoidance, or enhanced resource acquisition. These groups often develop a social network and/or dominance hierarchy within the population, with certain individuals gaining advantages or disadvantages based upon one’s rank within a group. Dominance hierarchies can be assessed on the grounds of structure, and, more recently, steepness.  Structure can be assessed by determining and comparing the rank of each individual (quantified by David’s scores). These scores can then be plotted and analyzed to determine the steepness of the dominance hierarchy. A dominance hierarchy …

Sedentary Behaviors And Measured Physical Activity In College Student Populations, Vanessa Grout, Elizabeth A. Easley, Sarah H. Sellhorst, William F. Riner

Caravel Undergraduate Research Journal

No abstract provided.

The Victimization Of Heterosexual Males: A Literature Review On Domestic Violence, Chris Friendly, Christine Palmer Mph, Edd, Ches

Caravel Undergraduate Research Journal

Domestic violence, defined as both emotional and physical abuse in intimate relationships, is a pressing issue in today’s society. Because of its serious nature, domestic violence has become a topic of great interest and concern for many public health researchers. However, an overwhelming degree of the studies conducted by these investigators only examine the effects of domestic violence on the female population. In this literature review, 27 sources, both peer-reviewed articles and literature reviews, were previewed. Of the 27 sources, only four were specific to male victimization. This literature review highlights the research disparity between female and male domestic violence …

Learning Organic Chemistry Reactions As A Nursing Student, Anna Bell

Caravel Undergraduate Research Journal

This paper delineates a clear way to learn the fundamentals of organic chemistry and biochemistry for students ranging from those preparing for careers in the health field to non-science majors. It looks in depth at the reactions relevant to the biochemical processes of the human body, such as the reactions involving alcohols, carboxylic acids, esters, amines, amides, and disulfides. The objective is to present the subject matter in such a way that peer students can clearly relate it to topics relevant to their particular fields of study. This can be done using mnemonic assists such as acronyms, or by using …

Learning About Learning: Cognitive Gaming As A Technology Of The Self, David Corso

Caravel Undergraduate Research Journal

Humans perceive and interpret video games in various ways. When viewed as a cognitive process, video games facilitate intellectual growth and development. This piece analyzes selected works by French intellectual Michel Foucault and educational game design researcher Kurt Squire to explain how video game play elicits various cognitive and metacognitive processes. The video discusses how gameplay contributes to the development of cognitive skills, such as memory and attention. It explains how gameplay facilitates learning about learning as well as how video games provide transferable knowledge. An interpretation of Foucault’s “technology of the self” indicates how individuals might use gameplay to …