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Articles 3301 - 3330 of 325583
Full-Text Articles in Entire DC Network
Multidomain Expert Evaluation Of Leading Large Language Models As Providers Of Vaccination And Preventive Medicine Information, Marcello Di Pumpo, Leonardo Villani, Vittorio Maio, Maria Rosaria Gualano, Eleonora Marziali, Lucia De Maio, Rossella Mancini, Stefania Boccia, Walter Ricciardi, Patrizia Laurenti
Multidomain Expert Evaluation Of Leading Large Language Models As Providers Of Vaccination And Preventive Medicine Information, Marcello Di Pumpo, Leonardo Villani, Vittorio Maio, Maria Rosaria Gualano, Eleonora Marziali, Lucia De Maio, Rossella Mancini, Stefania Boccia, Walter Ricciardi, Patrizia Laurenti
College of Population Health Faculty Papers
OBJECTIVES: Vaccination is one of the most effective public health interventions. Large language models (LLMs) show great capability for providing health information. This study compared the performance of ChatGPT 3.5 (G3E), ChatGPT 4o in English (G4E), Claude 3.0 (CDE), Gemini 1.5 (GME), and ChatGPT 4o in Italian (G4I) in delivering information on vaccination and preventive medicine.
STUDY DESIGN: Mixed-method analysis evaluating large language models.
METHODS: Twenty-six expert-designed healthcare scenarios were used to evaluate each model through an adapted DISCERN-based instrument. Four experts independently rated outputs across six domains: Information Reliability, Information Quality, Medical Appropriateness, Impact on Vaccine Hesitancy, Potential for …
Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman
Rape Pregnancies And Consequent Ptsd Resulting From The Overturn Of Roe V. Wade, Emma Lindenfelser, Yulia Garaeva, Nenette Nti-Agyemang, Ellen Davis, Anna Kabwa, Alexandra M Calaman
Binghamton University Undergraduate Journal
Prior to the 1973 Roe v. Wade ruling, access to safe legal abortions was limited and often restricted along racial, economic, and geographic lines. Nearly fifty years later, women’s health policy evolved again following the 2022 Dobbs v. Jackson Women’s Health Organization decision overturning Roe v. Wade. This court ruling decimated federal protections of abortion. This paper presents the research that the 2022 Dobbs judicial decision may contribute to and exacerbate rape-related PTSD on 1 out of 20 American who are unable to access a safe abortion after a rape-related pregnancy. Pregnant women living in conservative states that have outlawed …
Patterns Of Language And Visuospatial Lateralisation In Three-Year-Old Children, Josephine E. Quin-Conroy, Donna M. Bayliss, Stephanie J. Bovell, Debra Eamer, Georgina H.M. Earl, Simon E. Fisher, Clyde Francks, Murray T. Maybery, Sarah Pillar, Desiree Silva, Andrew J.O. Whitehouse, Nicholas A. Badcock
Patterns Of Language And Visuospatial Lateralisation In Three-Year-Old Children, Josephine E. Quin-Conroy, Donna M. Bayliss, Stephanie J. Bovell, Debra Eamer, Georgina H.M. Earl, Simon E. Fisher, Clyde Francks, Murray T. Maybery, Sarah Pillar, Desiree Silva, Andrew J.O. Whitehouse, Nicholas A. Badcock
Research outputs 2022 to 2026
Little is known about how or when language and visuospatial processing lateralise in the brain, and if individual differences in lateralisation are related to early language or visuospatial abilities. We explored if patterns of language and visuospatial lateralisation are related to cognitive skills in young children. A large sample of 3-year-olds (n = 136) attempted two functional transcranial Doppler ultrasound (fTCD) tasks to estimate language and visuospatial lateralisation. At the group level, language was lateralised to the left hemisphere, but visuospatial processing was weakly lateralised to the right hemisphere. The relationship between patterns of lateralisation and cognitive skills was investigated …
Comments On The Letter “Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Abdullah Saeed
Journal of the Saudi Heart Association
No Abstract for this article type.
Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Ahmed Almohammadi
Bridging The Gap: The Critical Next Steps For Implementing Genetic Risk Scores In Myocardial Infarction Prevention In Saudi Arabia, Ahmed Almohammadi
Journal of the Saudi Heart Association
No Abstract for this article type.
Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs
Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs
Journal of Interprofessional Practice and Collaboration
The prevalence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing among adults aged 50 years and older in the United States, posing a significant public health challenge. In 2021, an estimated 38.4 million Americans had diabetes, with adults aged 50years and above constituting a disproportionately large segment of this population. Evidence suggests that community-based lifestyle and educational interventions are effective in reducing the risk of T2DM among older adults. These interventions particularly promote dietary modification, increased physical activity, and diabetes education. Integrating the expertise of nurses, dietitians, pharmacists, physicians, and other professionals through interprofessional collaboration strengthens diabetes prevention and …
Exploring Interprofessional End-Of-Life Communication Through Simulation: A Qualitative Study, Stephanie Jeffers Phd, Rn, Eric Stein Dsw, Lsw, Meg Hall Phd, Rn, Caroline Campbell Phd, Lsw, Carly King Msw, Lsw
Exploring Interprofessional End-Of-Life Communication Through Simulation: A Qualitative Study, Stephanie Jeffers Phd, Rn, Eric Stein Dsw, Lsw, Meg Hall Phd, Rn, Caroline Campbell Phd, Lsw, Carly King Msw, Lsw
Journal of Interprofessional Practice and Collaboration
Purpose: The purposes of this qualitative descriptive study were to understand the perceptions of nursing and social work students regarding communication with patients and families at the end of life and to explore the perceptions of nursing and social work students' regarding interprofessional roles at the end of life.
Methods: An interdisciplinary simulation about death and dying was conducted with 16 undergraduate nursing students and 3 graduate social work students to understand their perceptions regarding communication with patients and families at the end of life and to explore their perceptions of interprofessional roles. Simulations lasted approximately 20 minutes and were …
Evaluating Interprofessional And Cultural Competency: A Community-Mental Health Interprofessional Education Event, Megan A. Whitbeck, Carrie A. Griffiths, William F. Miller, Laura M. Skoronski Chavez, Krisy Elrod, Autumn M. Forgione, Anna L. Grippi, John P. Merchant
Evaluating Interprofessional And Cultural Competency: A Community-Mental Health Interprofessional Education Event, Megan A. Whitbeck, Carrie A. Griffiths, William F. Miller, Laura M. Skoronski Chavez, Krisy Elrod, Autumn M. Forgione, Anna L. Grippi, John P. Merchant
Journal of Interprofessional Practice and Collaboration
Purpose: This study examined the effectiveness of a mental health focused interprofessional education (IPE) event, where undergraduate and graduate students from four different healthcare disciplines collaboratively completed a case study activity, that included diversity and mental health components.
Methods: A quasi-experimental, one-group pretest–posttest design was used. Participants included 72 undergraduate and graduate students from nursing, occupational therapy, health administration, and counseling programs at a private university. Students engaged in a structured team-based activity emphasizing communication, collaboration, and cultural responsiveness in a mental health care context. Self-reported measures included the Interprofessional Collaborative Competency Attainment Survey (ICCAS) and the Cultural …
The State Of Interprofessional Education And Collaborative Practice In Ghana: Experts’ Perspective, Amy Bening, Victor Mogre, Yolande Heymans, Christmal Dela Christmals
The State Of Interprofessional Education And Collaborative Practice In Ghana: Experts’ Perspective, Amy Bening, Victor Mogre, Yolande Heymans, Christmal Dela Christmals
Journal of Interprofessional Practice and Collaboration
ABSTRACT
Purpose: Interprofessional education (IPE) has gained recognition as the best form of preparing health professionals for Interprofessional Collaborative Practice (IPCP) in the healthcare settings. As such, many countries have inculcated IPE into the training of health professionals, but the state of IPE in the Ghana is unknown. Therefore, this study sought to explore the state of IPE and IPCP in Ghana.
Methods: The study employed a qualitative descriptive study in which 16 key informants were interviewed, and data was thematically analysed to describe the state of IPE and IPCP in Ghana.
Results: Three themes were identified and described: IPCP …
Community Health Fair As Experiential Learning: Interprofessional Faculty And Student Perspectives, Sharon Stevenson, Martha Rojo, Jing Jin, Erickson Feliciano, Margaret Love, Scott Wright
Community Health Fair As Experiential Learning: Interprofessional Faculty And Student Perspectives, Sharon Stevenson, Martha Rojo, Jing Jin, Erickson Feliciano, Margaret Love, Scott Wright
Journal of Interprofessional Practice and Collaboration
Abstract
Background: Traditional, precepted clinical practice sites continue to decline. Community health fairs (CHFs), led by experienced interprofessional faculty, present a valuable opportunity. In addition, CHFs provide students with hands-on experience in real-world settings.
Aim: This study examined the perspectives and clinical experiences of interprofessional faculty and students participating in a CHF.
Methods: This study utilized qualitative and quantitative design. Fourteen participants (seven students, seven faculty) engaged in conversational interviews, and completed a faculty and student survey as well as a demographic survey. Descriptive statistics were used to describe the sample and survey responses, and thematic analysis was used to …
Transforming Student And Patient Lives In Guatemala, Ryan J. Grippo, Jarett C. Worden, Lawrence B. Stack, Kamini V. Kabilan, Aakanksha S. Khadye, Edison Nwobi, Sydney G. Wisnefski
Transforming Student And Patient Lives In Guatemala, Ryan J. Grippo, Jarett C. Worden, Lawrence B. Stack, Kamini V. Kabilan, Aakanksha S. Khadye, Edison Nwobi, Sydney G. Wisnefski
Cumberland Medica
Abstract: Interprofessional healthcare service-learning experiences provide the environment for transformative growth of students. Belmont University’s faculty from the Frist College of Medicine and the College of Pharmacy and Health Sciences created an interprofessional healthcare service-learning experience for medical students and pharmacy students. This experience includes providing hands-on care in community health clinics in Guatemala as well as touring healthcare facilities in Guatemala. This reflection article highlights the details of the inaugural session of this experience and the transformative quality of this experience from the student perspective.
Agenda (Pdf), School Of Dentistry
Agenda (Pdf), School Of Dentistry
LSU School of Dentistry Research Day
Agenda for the LSUSD Research Day held June 5, 2026.
Exploring The Dual Impact Of A Graduate-Led Physical Therapy Experience On Undergraduate Engagement And Graduate Professional Development: A Case Report, Ellie Trubey, Jennifer Bochynski, Michelle Slike
Exploring The Dual Impact Of A Graduate-Led Physical Therapy Experience On Undergraduate Engagement And Graduate Professional Development: A Case Report, Ellie Trubey, Jennifer Bochynski, Michelle Slike
Internet Journal of Allied Health Sciences and Practice
Purpose: The significance of connectedness, motivation, and professional identity formation in healthcare education is well documented in recent research. The purpose of this case report is to evaluate the impact of an interactive, peer-led learning experience between graduate physical therapy students and undergraduate pre-physical therapy students. A specific focus is placed on identifying the effect this professional early-exposure event had on each group’s perceived connectedness to the program, motivation to continue studying physical therapy, and a developing professional identity. Methods: Graduate physical therapy students designed and facilitated a hands-on learning session for first-year pre-physical therapy undergraduates. Post-event surveys were used …
It's (Not) Raining Men: Exploring The Themes Surrounding Low Male Presence In Pediatric Nursing, Marcin Janczak
It's (Not) Raining Men: Exploring The Themes Surrounding Low Male Presence In Pediatric Nursing, Marcin Janczak
Honors Projects
Background: Men remain underrepresented in nursing, with an even smaller presence in pediatric nursing. Purpose: To examine pediatric-specific themes that may contribute to the low presence of men in pediatric nursing, and strategies to counteract these potential barriers. Methods: CINAHL Ultimate and Google Scholar were searched for primary research published from 2015 to 2025 related to male nurses, male nursing students, gender bias, pediatric care, and clinical experiences. Findings: Four major themes emerged: gender stereotypes and the feminization of pediatric nursing, sociocultural barriers and gender bias, fear and distrust toward male nurses, and psychological and professional impacts on men in …
Decoding Growth Hormone Actions On Human Growth Plate Stem Cells, Shion Orikasa, Noriaki Ono
Decoding Growth Hormone Actions On Human Growth Plate Stem Cells, Shion Orikasa, Noriaki Ono
Faculty, Staff and Student Publications
The epiphyseal growth plate is the key target of growth hormone (GH) therapy. Although growth plate stem cells are well defined in mice, their presence in humans was unclear. Using rare surgical specimens, the study by Chu et al. reveals conserved, GH-responsive stem cells in the human pubertal growth plate.
Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team
Growth In Early Infancy Drives Optimal Brain Functional Connectivity Which Predicts Cognitive Flexibility In Later Childhood, Chiara Bulgarelli, Anna Blasi, Samantha Mccann, Bosiljka Milosavljevic, Giulia Ghillia, Ebrima Mbye, Ebou Touray, Tijan Fadera, Lena Acolatse, Sophie E Moore, Sarah Lloyd-Fox, Clare E Elwell, Adam T Eggebrecht, Bright Study Team
2020-Current year OA Pubs
Functional brain network organisation, measured by functional connectivity (FC), reflects key neurodevelopmental processes for healthy development. Early exposure to adversity, for example undernutrition, affects neurodevelopment, observable via disrupted FC, and leads to poorer outcomes from preschool age onwards. We assessed longitudinally the impact of early growth trajectories on developmental FC in a rural Gambian population from age 5-24 months. To investigate how these early trajectories relate to later childhood outcomes, we assessed cognitive flexibility at 3-5 years. We observed that early physical growth before the fifth month of life drove optimal developmental trajectories of FC that in turn predicted cognitive …
Narrative Discourse Predictors Of Response To Naming Intervention In Aphasia, Dirk B. Den Ouden, Laura Giglio, Sigfus Kristinsson, Leonardo Bonilha, Deena Schwen Blackett, Brielle C. Stark, Janina Wilmskoetter, Julius Fridriksson
Narrative Discourse Predictors Of Response To Naming Intervention In Aphasia, Dirk B. Den Ouden, Laura Giglio, Sigfus Kristinsson, Leonardo Bonilha, Deena Schwen Blackett, Brielle C. Stark, Janina Wilmskoetter, Julius Fridriksson
Communication Sciences and Disorders Faculty Articles and Research
Purpose:
While aphasia treatment studies commonly use picture-naming performance as an outcome measure, narrative discourse better reflects functional language use. Discourse variables may also hold prognostic value for naming treatment response, but their predictive role remains underexplored.Method:
We analyzed baseline and posttreatment narrative discourse samples from 95 chronic stroke survivors with aphasia enrolled in a lexical retrieval intervention study. Participants received 3 weeks each of phonological and semantic naming therapy in a crossover design. The Cinderella story retells were analyzed for a range of discourse features: mean length of utterance, words per minute, verbs per utterance, propositional density, type–token …Extraction Of Key Themes In Online Health Discourse Using Unsupervised Learning And Large Language Models, Miranda G. Scully
Extraction Of Key Themes In Online Health Discourse Using Unsupervised Learning And Large Language Models, Miranda G. Scully
Computer Science Senior Theses
Health online discussion boards are a modern platform that allow patients to interact with each other and the healthcare system as a whole, making them valuable sources of information for clinicians seeking to better anticipate treatment experiences and barriers. This study focuses on one such community, r/suboxone, a subreddit where patients using Suboxone share their experiences and ask questions. Our analysis is motivated by previous work that proposes event-based classification systems for such posts which buckets posts from r/suboxone into one or more of five high-level labels (Access Logistics, Co-Occurring Drug Usage, Medication for Opioid Use Disorder Administration, Psychophysical Effects, …
Rehabvr: A Virtual Reality System For Upper-Body Orthopaedic Physical Therapy Rehabilitation, Winnie Brenda Wanjiru Waiya
Rehabvr: A Virtual Reality System For Upper-Body Orthopaedic Physical Therapy Rehabilitation, Winnie Brenda Wanjiru Waiya
Computer Science Senior Theses
Physical therapy is a central component of rehabilitation for musculoskeletal conditions, yet adherence to prescribed treatment remains persistently poor. Jack et al. identified pain, boredom, and insufficient feedback as key barriers to treatment adherence in physiotherapy outpatient settings,¹ and Rucinski et al. confirmed that non-adherence rates in orthopaedic populations remain between 50 and 70%, with patients who disengage facing elevated risk of reoperation, progressive functional decline, and poor clinical outcomes.² According to the World Health Organization, approximately 1.71 billion people globally live with musculoskeletal conditions,³ with shoulder pain specifically carrying a community prevalence ranging from 0.67 to 55.2% worldwide and …
Why Are Some Children Under 24 Months Still Undernourished In Urban And Peri-Urban Vientiane? A Mixed-Methods Study, Kethmany Ratsavong, Dirk Essink, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Somphou Sayasone, Sengchanh Kounnavong, Jacqueline E. Broerse
Why Are Some Children Under 24 Months Still Undernourished In Urban And Peri-Urban Vientiane? A Mixed-Methods Study, Kethmany Ratsavong, Dirk Essink, Pamela J. Wright Phd, Ms, Med, Rn, Cen, Somphou Sayasone, Sengchanh Kounnavong, Jacqueline E. Broerse
Publications
Child undernutrition remains a significant public health challenge in many low and middle-income countries (LMICs), including Lao PDR, where high levels persist even in urban areas with generally available and accessible food. This study aimed to explore factors underlying the persistently high rates of undernutrition among young children in urban (Saysetha) and peri-urban (Pakgneum) districts of the Vientiane Capital in Lao PDR. A cross-sectional survey employed a sequential explanatory mixed-methods approach, combining a structured questionnaire of 333 mother-child pairs for quantitative analysis with semi-structured interviews of 47 caregivers for qualitative insights. The prevalence of malnutrition among children under 24 months …
Recommendations For Disclosure Of Artificial Intelligence In Scientific Writing And Publishing: A Regional Anesthesia And Pain Medicine Modified Delphi Study, Michael R Fettiplace, Anuj Bhatia, Yian Chen, Steven L Orebaugh, Michael Gofeld, Rodney A Gabriel, Daniel I Sessler, Hannah Lonsdale, Brittani Bungart, Christopher P Cheng, Garrett W Burnett, Lichy Han, Matthew Wiles, Steve Coppens, Thomas Joseph, Kristin L Schreiber, Thomas Volk, Richard D Urman, Vesela P Kovacheva, Christopher L Wu, Edward R Mariano, Vivian H Y Ip
Recommendations For Disclosure Of Artificial Intelligence In Scientific Writing And Publishing: A Regional Anesthesia And Pain Medicine Modified Delphi Study, Michael R Fettiplace, Anuj Bhatia, Yian Chen, Steven L Orebaugh, Michael Gofeld, Rodney A Gabriel, Daniel I Sessler, Hannah Lonsdale, Brittani Bungart, Christopher P Cheng, Garrett W Burnett, Lichy Han, Matthew Wiles, Steve Coppens, Thomas Joseph, Kristin L Schreiber, Thomas Volk, Richard D Urman, Vesela P Kovacheva, Christopher L Wu, Edward R Mariano, Vivian H Y Ip
Faculty, Staff and Student Publications
Introduction: The use of artificial intelligence (AI) in the scientific process is advancing at a remarkable speed, thanks to continued innovations in large language models. While AI provides widespread benefits, including editing for fluency and clarity, it also has drawbacks, including fabricated content, perpetuation of bias, and lack of accountability. The editorial board of Regional Anesthesia & Pain Medicine (RAPM) therefore sought to develop best practices for AI usage and disclosure.
Methods: A steering committee from the American Society of Regional Anesthesia and Pain Medicine used a modified Delphi process to address definitions, disclosure requirements, authorship standards, and editorial oversight …
Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell
Monoclonal Antibodies Targeting Pcdh7 Inhibit Tumor Growth And Enhance Immune Responses In Kras-Mutant Non-Small Cell Lung Cancer, Nicole Novaresi, Poorva Ghosh, Shayna Thomas-Jardin, Hui Deng, Xuejun Fan, Zhiqiang Ku, Wei Xiong, Xiaorong Zhou, Jingfei Zhu, Huiyu Li, Mahesh S Padanad, Bethany Smith, Chul Ahn, John D Minna, Zhiqiang An, Ningyan Zhang, Kathryn A O'Donnell
The Brown Foundation: Institute of Molecular Medicine
We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate this cell surface protein as an actionable therapeutic target and highlight the therapeutic potential of PCDH7 inhibition for non–small cell lung cancer. We report the development and characterization of high-affinity anti-PCDH7 monoclonal antibodies (mAbs) that inhibit downstream mitogen-activated protein kinase (MAPK) pathway activation and suppress tumor growth in multiple mutant KRAS–driven models. A lead mAb (mAb7) sensitized tumors …
Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty
Amc-F1 Regulates Mitochondria-Autophagy Crosstalk Independent Of Nutrient Stress, Yuqin Wang, Raksha K Rao, Trung Vu, Ayano Sekine, Zhengmei Mao, Nami Mccarty
The Brown Foundation: Institute of Molecular Medicine
Mitochondria and autophagy are fundamental yet distinct regulators of cellular homeostasis. Here, we identify AMC-F1 (Autophagy-Mitochondria Coupling Factor 1; formerly TRIM44) as a central integrator of mitochondrial bioenergetics and autophagy. Using Amcf1 knockout and knock-in mouse models, we demonstrate that AMC-F1 bidirectionally regulates these pathways: its loss reduces mitochondrial respiration and autophagic flux, whereas its overexpression promotes mitochondrial elongation and increases autophagy independently of nutrient stress. Transcriptomic analyses reveal AMC-F1-dependent regulation of mitochondrial biogenesis programs that engage autophagy, involving mitochondrial respiratory chain complex genes under basal conditions and mitochondrial organization factors under starvation-induced autophagy. Although dispensable under homeostasis, this coupling …
Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna
Imaging And Non-Imaging Approaches For The Diagnosis And Monitoring Of Necrotizing Enterocolitis-What Lies Ahead?, Indrani Bhattacharjee, Catalina Le Cacheux, Eric B. Ortigoza, Jonathan Dillman, Sherwin S. Chan, Alain Cuna
Manuscripts, Articles, Book Chapters and Other Papers
Necrotizing enterocolitis (NEC) remains one of the most serious gastrointestinal emergencies in preterm infants, and imaging plays a central role in diagnosis and clinical management. Historically, evaluation has relied primarily on abdominal radiography, which remains widely available and embedded in established diagnostic frameworks. However, the hallmark radiographic signs of NEC (i.e., pneumatosis intestinalis, portal venous gas, and free air) reflect relatively advanced manifestations of intestinal injury that indicate established mucosal disruption or transmural necrosis. Bowel ultrasound has increasingly complemented radiography by enabling real-time assessment of bowel wall integrity, perfusion, motility, and intra-abdominal fluid, providing physiologic information that may refine clinical …
Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner
Disease-Causing Mfn2 Mutants Impair Mitochondrial Fission Dynamics By Distinct Drp1 Dysregulation, Daniel Lagos, Pamela R. De Santiago, Nicolás Pérez-Bravo, Benjamín Cartes-Saavedra, Josefa Vial-Brizzi, Diego Troncoso-Chandía, Oliver Podmanicky, Rita Horvath, Verónica Eisner
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Mitochondria undergo fusion and fission. While DRP1 regulates fission, fusion is controlled by OPA1, MFN1, and MFN2. The balance between these processes and the crosstalk between machineries remains poorly understood. MFN2 mutations cause Charcot-Marie-Tooth disease type 2 A (CMT2A), affecting mitochondrial fusion and morphology. However, their role in fission is unclear. Using skin fibroblasts from CMT2A patients (L248H and M376V MFN2 mutations) and wild-type mouse embryonic fibroblasts expressing these variants, we studied how MFN2 mutations impact mitochondrial dynamics beyond fusion. We analyzed mitochondrial morphology and dynamics by live-cell confocal microscopy and tested fusion/fission protein levels, oxygen consumption rate (OCR), extracellular …
Targeted Reflex Rna Sequencing For Enhanced Variant Classification On Exome And Genome Sequencing Improves Patient Outcomes, Xiaonan Zhao, Robert Rigobello, Morgan Driver, Sydney Lau, Mei Ling Chong, Jason Chibuk, Hongzheng Dai, Wilson C W Wu, Christina Peroutka, Laura Famularo, Alexander Y Kim, Bailey Hummel, Sarah Dugan, Tinsley Douglas, Linyan Meng, Fan Xia, Christine M Eng
Targeted Reflex Rna Sequencing For Enhanced Variant Classification On Exome And Genome Sequencing Improves Patient Outcomes, Xiaonan Zhao, Robert Rigobello, Morgan Driver, Sydney Lau, Mei Ling Chong, Jason Chibuk, Hongzheng Dai, Wilson C W Wu, Christina Peroutka, Laura Famularo, Alexander Y Kim, Bailey Hummel, Sarah Dugan, Tinsley Douglas, Linyan Meng, Fan Xia, Christine M Eng
Faculty, Staff and Students Publications
RNA sequencing (RNA-seq) has been utilized to provide functional evidence regarding the impact of splicing variants. This study explores the utility of targeted reflex RNA-seq to inform classification of predicted splicing variants identified through clinical exome sequencing (ES) and genome sequencing (GS). A retrospective analysis was conducted on consecutive ES/GS cases completed at a single center in which targeted reflex RNA-seq was performed following identification of eligible variants. There were 131 cases (4.1%) that had at least one RNA-seq eligible variant reported, with eight of these cases having two unique eligible variants. Of the 139 eligible variants, 125 were classified …
Safety And Synergy Of Finerenone And Empagliflozin In Lowering Blood Pressure, Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B Mcgill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann
Safety And Synergy Of Finerenone And Empagliflozin In Lowering Blood Pressure, Rajiv Agarwal, Ricardo Correa-Rotter, Sankar D Navaneethan, Hiddo J L Heerspink, Matthew R Weir, Janet B Mcgill, Amy K Mottl, Masaomi Nangaku, Julio Rosenstock, Peter Rossing, Muthiah Vaduganathan, Charlie Scott, Li Li, Meike Brinker, Csaba P Kovesdy, Jennifer B Green, Johannes F E Mann
Faculty, Staff and Students Publications
Background: This secondary analysis of the CONFIDENCE (combination effect of fInerenone and empagliflozin in participants with chronic kidney disease and type 2 diabetes using a UACR endpoint) trial (REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05254002) assessed systolic blood pressure (SBP) changes with empagliflozin/finerenone combination therapy versus monotherapy in people with chronic kidney disease and type 2 diabetes across baseline SBP categories. We assessed SBP response predictors and whether early (day 30) SBP changes mediate urinary albumin-to-creatinine ratio reductions.
Methods: Participants (n=800) were stratified by baseline SBP (< 130 mm Hg; ≥130 mm Hg). Outcomes included SBP response (≥10 mm Hg reduction from baseline at day 180) and longitudinal SBP changes, analyzed by linear mixed-effects models and logistic regression. Causal mediation analysis, a secondary exploratory analysis, evaluated the effect of day 30 SBP change on day 180 urinary albumin-to-creatinine ratio reduction.
Results: At baseline, 532 (66%) participants had SBP ≥130 mm Hg; 268 (34%) …
Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre
Evaluating Chest-Worn Light Logger Adherence: Development And Application Of A Wear/Non-Wear Model, Carlyn Patterson Gentile, Adah Thomas, Ryan Shah, Blanca Marquez De Prado, Nichelle Raj, Christina Szperka, Geoffrey Aguirre
Student Papers, Posters & Projects
Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of …
Histone Deacetylase Enzyme Activity Is Not The Universal Anticancer Target Of Hdac Inhibitors, Chaitra Rai, Hang Ruan, Xue Li, Wenbo Li, Hyun-Hwan Jeong, Chengchuang Song, Panpan Liu, Yingjie Chang, Hao Fang, Udhaya Kumar S, Yuxiang Sun, M James You, Dongyin Guan, Zhandong Liu, Leng Han, Xuben Hou, Zheng Sun
Histone Deacetylase Enzyme Activity Is Not The Universal Anticancer Target Of Hdac Inhibitors, Chaitra Rai, Hang Ruan, Xue Li, Wenbo Li, Hyun-Hwan Jeong, Chengchuang Song, Panpan Liu, Yingjie Chang, Hao Fang, Udhaya Kumar S, Yuxiang Sun, M James You, Dongyin Guan, Zhandong Liu, Leng Han, Xuben Hou, Zheng Sun
Faculty, Staff and Students Publications
Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found that, for most cancer types, expression levels or genetic variants of histone deacetylase (HDACs) do not consistently correlate with carcinogenesis, do not predict cancer patient survival, and do not associate with cellular responses to HDIs. Whole-genome CRISPR library screens did not identify HDACs as genes affecting cellular responses to HDIs. Overexpression of dominant-negative Class I HDACs causes similar protein hyperacetylation …
Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong
Current Status Of Anthelmintic Resistance In Meat Goats: A Comparative Efficacy Study Of Albendazole And Fenbendazole In Maha Sarakham, Thailand, Minta Pipatsakulpak, Usanisa Boonum, Kotchakorn Roongruang, Benjawan Sae-Chue, Sukanya Leethongdee, Songsak Chumpawadee, Nattaya Watwiengkam, Pongphol Pongthaisong
The Thai Journal of Veterinary Medicine
Anthelmintic resistance in gastrointestinal nematodes threatens sustainable goat production globally. While resistance is well-documented in many regions, data from Thailand remain limited. This study determined the prevalence of gastrointestinal nematodes and assessed the efficacy of albendazole and fenbendazole in meat goats in Maha Sarakham province, northeastern Thailand. A two-stage cross-sectional study was conducted on 10 meat goat farms between August 2021 and March 2022. In Stage 1, fecal samples from 150 goats were examined using simple flotation and sedimentation techniques to identify parasite morphology. In Stage 2, the McMaster technique was employed to quantify fecal egg counts (FEC). Twenty-six goats …