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Immunology And Disease Of The Kidney, William F. Falls Jr. Jan 1977

Immunology And Disease Of The Kidney, William F. Falls Jr.

MCV/Q, Medical College of Virginia Quarterly

The emphasis of this paper is the review of several aspects of renal disease which have immunologic overtones and clinical relevance. The pathogenesis of several subtypes of glomerulonephritis will be discussed, the immunologic implications of amyloidosis will be noted, and the relation between immune mechanisms and tubulointerstitial disease will be mentioned. The discussion will then be completed by an analysis of the prognosis of the aforementioned renal disease, and by an attempt to place contemporary therapeutic modalities in a proper perspective.

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Genetics And Cancer, John M. Mueller, Robert B. Diasio Jan 1977

Genetics And Cancer, John M. Mueller, Robert B. Diasio

MCV/Q, Medical College of Virginia Quarterly

The existence of a relationship between cancer and heredity has been recognized for years, but only recently has emerging knowledge in this area enabled physicians to detect and treat cancer earlier in affected individuals and to prevent its occurrence in others.

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The Search For Optimal Management Of Head Injury, J. Douglas Miller Jan 1977

The Search For Optimal Management Of Head Injury, J. Douglas Miller

MCV/Q, Medical College of Virginia Quarterly

Head injuries of sufficient severity to bring the patient to a hospital occur in more than one per hundred of the population every year. The toll in death and disability is staggering: the majority of patients are young wage-earners with families so that the total socio-economic burden can hardly be guessed at. Much emphasis is laid on the concept that physical disruption of neurons in the brain is not a reversible process and that regeneration within the nervous system to the point of functional recovery does not occur; however, this rather dismal view of head injury is at variance with …

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New Approaches To The Use Of Twins In Biomedical Research, Walter E. Nance Jan 1977

New Approaches To The Use Of Twins In Biomedical Research, Walter E. Nance

MCV/Q, Medical College of Virginia Quarterly

Human geneticists are often accused of being preoccupied with exotic syndromes that are of marginal relevance to the general population. Brilliant success has been achieved during the past two decades in defining the nature and function of the genetic material, the molecular pathology of a large number of metabolic diseases, the phenotype of more than 2,000 Mendelian traits, and more recently the chromosomal location of a rapidly expanding number of human gene pairs. In contrast, relatively little progress has been made in the genetic analysis of quantitative traits such as blood pressure, serum cholesterol, intelligence quotient, skin color, height, birth …

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Dominantly Inherited Amyotrophic Lateral Sclerosis (Motor Neuron Disease), Louise E. Wilkins, Robin M. Winter, Edwin C. Myer, Walter E. Nance Jan 1977

Dominantly Inherited Amyotrophic Lateral Sclerosis (Motor Neuron Disease), Louise E. Wilkins, Robin M. Winter, Edwin C. Myer, Walter E. Nance

MCV/Q, Medical College of Virginia Quarterly

The term amyotrophic lateral sclerosis was first introduced by Charcot to describe cases with mixed upper and lower motor neuron signs without sensory impairment. Later the syndromes of progressive bulbar palsy (PBP) and progressive muscular atrophy (PMA) were recognized to be variations of the same pathological process, and ALS was used as an inclusive term to refer to these syndromes as well. Although some authors reserve the term ALS for the specific syndrome of mixed upper and lower motor neuron lesions and use the term “motor neuron disease” to refer to the constellation of syndromes, most of the literature on …

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A New Familial Chondrodystrophy Simulating Parastremmatic Dwarfism, Wendy L. Golden, Peter Mamunes, Michael B. Kodroff Jan 1977

A New Familial Chondrodystrophy Simulating Parastremmatic Dwarfism, Wendy L. Golden, Peter Mamunes, Michael B. Kodroff

MCV/Q, Medical College of Virginia Quarterly

Recent developments in tissue culture and enzyme analysis have made it possible to classify more precisely some of the skeletal dysplasias and to understand their pathophysiology; thus almost all seven clinical types of mucopolysaccharidoses are due to separate single enzyme deficiencies – one type, the Sanfilippo syndrome, has three subtypes, each with a different enzyme deficiency. The majority of the skeletal dysplasias have no definable biochemical abnormality and are classified on the basis of clinical and radiological findings and the mode of inheritance. The purpose of this report is to present a family with an apparently new type of chondrodystrophy.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 4 Jan 1977

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 4

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 2 Jan 1977

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 2

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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Somatostatin: Diverse Physiological Roles And Therapeutic Implications, Gordon C. Weir, S. Bonner Weir Jan 1977

Somatostatin: Diverse Physiological Roles And Therapeutic Implications, Gordon C. Weir, S. Bonner Weir

MCV/Q, Medical College of Virginia Quarterly

In its brief lifetime as a known peptide, somatostatin has provided a truly remarkable story filled with surprising developments from unexpected quarters. The foundation was set in 1969, when Krulich and McCann reported that fractions of a crude hypothalamic extract inhibited the secretion of growth hormone. In 1973, Guillemin's laboratory reported the sequence and synthesis of a fourteen amino acid peptide with the same inhibitory effect. It occurs in both a cyclic and linear form, each displaying equal biological activity. Somatostatin was assigned as its name, but it is also commonly referred to as growth hormone release inhibitory factor (GHRIF) …

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Differential Diagnosis Of Progressive Generalized Or Symmetrical Flaccid Paralysis, Edward R. Isaacs Jan 1977

Differential Diagnosis Of Progressive Generalized Or Symmetrical Flaccid Paralysis, Edward R. Isaacs

MCV/Q, Medical College of Virginia Quarterly

Progressive flaccid paralysis occurring over a period of hours or days is usually associated with the Landry-Guillain-Barré-Strohl syndrome. This symptom complex is often accompanied by a history of previous flu-like illness, antecedent myalgias, and subjective sensory complaints of tingling or simply a “tight” sensation in hands and feet. The paralysis that ensues either ascends from the feet and legs or descends from the facial muscles to involve all or most of the voluntary skeletal musculature. Along with paralysis of the intercostal and diaphragmatic musculature, severe cases may also involve other cranial nerves as well as the autonomic nervous system. In …

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Cancer: The Great Challenge For Immunology, Gerald Goldstein Jan 1977

Cancer: The Great Challenge For Immunology, Gerald Goldstein

MCV/Q, Medical College of Virginia Quarterly

The existence of immunity to cancer was postulated by the eminent scientists who helped to establish the discipline of immunology. In 1907 Clowes suggested that human resistance to cancer resulted from what we today call “immune surveillance.” During the ensuing 70 years the results obtained from experimental animal cancers and human cancers have greatly influenced the palatability of tumor-immunity theories. Early optimism that immunity to cancer could be specifically induced waned and almost disappeared when it was demonstrated that the rejection of cancer transplants resulted from transplantation immunity and not tumor immunity. A sustained wave of enthusiasm for immunity to …

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Why Control Diabetes?, Harold Rifkin Jan 1977

Why Control Diabetes?, Harold Rifkin

MCV/Q, Medical College of Virginia Quarterly

The definition of diabetes control varies widely among specialists of the disease. Proponents of "good" control believe that the goals of appropriate therapy for diabetes should include an all-out effort to obtain levels of fasting and postprandial blood glucose as close to those in the non-diabetic as possible. Certainly, good control has been proven to accomplish the following: 1. prevention of ketoacidosis; 2. prevention of severe hypoglycemia; 3. decrease in perinatal mortality and morbidity; 4. promotion of normal growth and development of the juvenile diabetic; 5. prevention of, or inhibition of, infection. The evidence that hyperglycemia is responsible for vascular …

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The Growth And Development Of Genetics At Mcv, J. Ives Townsend Jan 1977

The Growth And Development Of Genetics At Mcv, J. Ives Townsend

MCV/Q, Medical College of Virginia Quarterly

Genetics was well established at the Medical College of Virginia by the time I joined the faculty in 1960. At least one course in genetics was required of students in the Schools of Medicine, Dentistry, Pharmacy, and Nursing. The Department of Biology and Genetics, which was in the School of Pharmacy and chaired by Dr. Roscoe D. Hughes, also had a modest graduate program in genetics and two genetics research programs, one on facial growth in twins, supported by a grant from the National Institutes of Health, and the other on the genetics of drosophila, supported by the National Science …

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Familial Occurrence Of Pierre Robin Anomalad, Wendy O. Segreti, Peter Mamunes Jan 1977

Familial Occurrence Of Pierre Robin Anomalad, Wendy O. Segreti, Peter Mamunes

MCV/Q, Medical College of Virginia Quarterly

We have presented a family in which three children (1 male and 2 females) who had two different fathers were affected with the Pierre Robin anomalad. The mother exhibits some of the characteristic stigmata of this syndrome which strongly suggests that an autosomal dominant from of the Pierre Robin anomalad exists with variable expressivity.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 3 Jan 1977

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 3

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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Narrative Summary: Health Care Administration, Summer Session 1977, Fern Brody Hogan Jan 1977

Narrative Summary: Health Care Administration, Summer Session 1977, Fern Brody Hogan

Student Scholarship

Unavailable.

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Diabetes In Children And Adolescents; Observations On Diabetic Microangiopathy, Elsa Proehl Paulsen Jan 1977

Diabetes In Children And Adolescents; Observations On Diabetic Microangiopathy, Elsa Proehl Paulsen

MCV/Q, Medical College of Virginia Quarterly

You may well wonder why I have combined a talk on diabetes in children and adolescents with one on diabetic microangiopathy when as pediatricians we rarely, if ever, see clinical evidence of the sequelae of vascular disease in our patients. If we see proteinuria in a child, we seek another cause. We may see young teenagers with a microaneurysm or a trace of protein, but we soon refer them to our internist friends who fall heir to the care of problems that doubtless have their beginning in childhood years. Pediatricians are, therefore, concerned about these problems and the adequacy of …

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Association Of Cystic Medial Necrosis Of The Aorta And Undiagnosed Thyroiditis [Scripta Medica], William S. Wise, John R. Hain Jan 1977

Association Of Cystic Medial Necrosis Of The Aorta And Undiagnosed Thyroiditis [Scripta Medica], William S. Wise, John R. Hain

MCV/Q, Medical College of Virginia Quarterly

We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered. The second patient died of a rupture of the ascending aorta. At autopsy, chronic thyroiditis was seen with multiple large germinal center and diffuse fibrosis. Neither patient was clinically suspected of thyroid dysfunction although the second patient had had a partial thyroidectomy in the remote past.

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A Diagnostic Approach To Acute Headache, Alan B. Grindal Jan 1977

A Diagnostic Approach To Acute Headache, Alan B. Grindal

MCV/Q, Medical College of Virginia Quarterly

Headache is one of the most common symptomatic ailments encountered by the physician. According to one estimate, headache constitutes the major complaint in more than 50% of patients seen in office practice. This figure refers to patients with chronic recurring headache, many of whom are seen electively when they are asymptomatic, and may not accurately reflect the frequency with which patients present, during the acute phase, complaining of head pain. The term acute headache refers to those episodes of cephalgia which lead the patient to seek immediate medical care.

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Author Index, Volume Thirteen, 1977. Jan 1977

Author Index, Volume Thirteen, 1977.

MCV/Q, Medical College of Virginia Quarterly

Author index for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen.

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Subject Index, Volume Thirteen, 1977. Jan 1977

Subject Index, Volume Thirteen, 1977.

MCV/Q, Medical College of Virginia Quarterly

Subject Index for MCV/Q, Medical College of Virginia Quarterly, 1977, Volume Thirteen.

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University Of South Alabama College Of Medicine Annual Report For 1977-1978, College Of Medicine Jan 1977

University Of South Alabama College Of Medicine Annual Report For 1977-1978, College Of Medicine

COM Annual Reports

This is the 1977-1978 College of Medicine Annual Report for the University of South Alabama.

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A Current Medical Reimbursement Practices And Prospects For National Health Insurance, Wallace D. Kinney Jan 1977

A Current Medical Reimbursement Practices And Prospects For National Health Insurance, Wallace D. Kinney

Theses Digitization Project

No abstract provided.

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Crisis Intervention Interpersonal Skills Training For Lay Volunteers, Gary J. Ladoceour Jan 1977

Crisis Intervention Interpersonal Skills Training For Lay Volunteers, Gary J. Ladoceour

Theses Digitization Project

No abstract provided.

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Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 1 Jan 1977

Mcv/Q, Medical College Of Virginia Quarterly, Vol. 13 No. 1

MCV/Q, Medical College of Virginia Quarterly

No abstract provided.

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Book Review, Frederick J. Spencer Jan 1977

Book Review, Frederick J. Spencer

MCV/Q, Medical College of Virginia Quarterly

Book reviews for Epidemics, Geoffrey Marks and William K. Beatty, Scribner's, 1976 and Plagues and Peoples, William H. McNeill, Doubleday, 1976.

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Introduction, David B. Walthall Jr. Jan 1977

Introduction, David B. Walthall Jr.

MCV/Q, Medical College of Virginia Quarterly

This issue of the MCV Quarterly is devoted to the 48th Annual McGuire Lecture Series held on February 12-13, 1977. The lectures, presented this year by the Department of Continuing Education, were designed to focus upon the ever-increasing amount of new information being generated in the field of immunology.

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Coma In Infancy And Childhood, Edwin C. Myer Jan 1977

Coma In Infancy And Childhood, Edwin C. Myer

MCV/Q, Medical College of Virginia Quarterly

Coma is defined as an altered state of consciousness from which arousal due to appropriate stimuli is not adequately achieved. Such a definition of the state of coma is plagued with semantic problems, and terminology describing various comatose states is vast and even more ambiguous when applied to the infant. Rather than using such terms as coma, semicoma, stupor, or obtundation, it is better to describe the physical state of the unresponsive patient. The description should include the patient’s appearance, movements either spontaneous or elicited from stimuli, the patient’s response to the stimulus, and the nature of the stimulus, whether …

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Acute Seizure Problems, Cary Suter Jan 1977

Acute Seizure Problems, Cary Suter

MCV/Q, Medical College of Virginia Quarterly

Seizures are a symptom and not a disease. A seizure is the result of an abnormal electrical discharge of a collection or group of living but damaged or abnormal neurons. When the group of neurons is in the cerebral cortex, a focal or partial seizure occurs, producing abnormal activity related to that part of the brain. The victim may experience a focal jerking or focal numbness, or flashing lights if the lesion is in the occipital lobe; or he or she may be subject to peculiar automatic behavior if the lesion is in the temporal lobe. When the activity spreads …

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Bacterial Meningitis: Some Epidemiologic And Clinical Factors In Diagnosis, Vincent P. Calabrese Jan 1977

Bacterial Meningitis: Some Epidemiologic And Clinical Factors In Diagnosis, Vincent P. Calabrese

MCV/Q, Medical College of Virginia Quarterly

In ancient times all acute delirium states were known as “phrenesis.” It was not until the 17th century that inflammations of the meninges and cerebrum were differentiated from each other. By the 19th century meningitis had been described to the extent that a number of epidemics were reported both in the United State and Europe, but it was the development of the lumbar puncture by Quincke in 1893 which opened up a new diagnostic era for the disease.

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