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Prospects For Clinical Research, G. Donald Whedon

Henry Ford Hospital Medical Journal

No abstract provided.

Transiliac Bone Biopsy: Complications And Diagnostic Value, Sudhaker D. Rao, Velimir Matkovic, Howard Duncan

Henry Ford Hospital Medical Journal

This article reviews the experience of 101 transiliac bone biopsies performed in one year at Henry Ford Hospital and discusses the possible diagnostic value ofthe procedure in evaluating generalized metabolic bone disease. In 50 of the 101 cases, we used a pain scoring method to evaluate the acceptability of the procedure to patients. Data from our study and 18 other clinical centers were then analyzed for: 1) demographic distribution of patients who had a bone biopsy; 2) its acceptability to patients; 3) quality of the specimen and its relationship to the physician performing the procedure; 4) diagnostic yield of bone …

Osteoporosis And Epidemiology Of Fractures In Croatia: An International Comparison, Velimir Matkovic, Marija Ciganovic, Cedomil Tominac, Krista Kostial

Henry Ford Hospital Medical Journal

We examined the epidemiology of osteoporotic fractures in Croatia and correlated the results with data from other countries. We analyzed annual rates of wrist fractures in the large urban community of Zagreb and hip fractures in the Republic of Croatia. In addition, we determined mortality data and measured metacarpal bone mass In patients with hip fractures. There were age and sex differences in the incidence of both types of fracture. The incidence of wrist fractures is the same as in some Northwestern European countries, but the incidence of hip fractures is much lower. The mortality after hip fractures is high …

The Acute Effect Of Piretanide Upon Serum And Urinary Calcium In Normal Subjects, Cristina Casco, Patricia Fainstein Day, Carlos Mautalen

Henry Ford Hospital Medical Journal

We gave piretanide, a new diuretic, at two dose levels to six normal subjects. Sodium excretion increased six to eightfold in the first two hours, and diuresis was completed within four hours. There was a simultaneous increase in the excretion of calcium which exceeded the amount present In the mobilized extracellular fluid. The resulting deficit of calcium produced a small but significant fall in serum calcium corrected for protein. After diuresis ended, calcium was retained but not sodium, when compared to basal values on the previous day. The fall in urinary calcium and the failure to correct the sodium deficit …

Cushing's Disease, A Pituitary Disorder: A Hypothesis, M. Saeed Zafar, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

At present, Cushing's disease Is believed to be due to Inappropriate secretion of adrenocorticotropic hormone (ACTH). Associated abnormalities such as disturbed sleep pattern, growth hormone secretion, depressed thyroid hormone levels, and gonadal function are considered by some as manifestations of a generalized central nervous system disturbance, with abnormal ACTH secretion as one of the components. Recognition of microadenomata in Increasing numbers of patients with Cushing's disease, the reversal of hypothalamic abnormalities after adenomectomy, and correction of hypercortisolemia all suggest that the central nervous system disturbances result from Cortisol excess. We hypothesize that the basic abnormality in Cushing's disease is the …

Painless Thyroiditis With Hyperthyroidism Following External Irradiation To The Neck, J. David Fachnie, Sudhaker D. Rao

Henry Ford Hospital Medical Journal

Two months after finishing 60Co external irradiation to treat squamous cell carcinoma of the larynx, a 47-year-old man became hyperthyrold. Although the thyroid gland was not tender, the radioactive iodine uptake was diminished. After subsequent periods of euthyroidism and hypothyroidism, the patient's thyroid function spontaneously returned to normal. The features of this case mimic the syndrome of painless granulomatous thyroiditis. Although hypothyroidism is frequently observed following radiation thyroiditis, hyperthyroidism from external radiation has not been reported. Despite this low frequency, diagnosis is important to permit prompt, symptomatic treatment of the thyrotoxic phase.

Graves' Disease Following The Occurrence Of Hypothyroidism, A. R. Guansing, D. D. Klink, N. Engbring, Y. Leung, J. Chakravarty, S. Wilson

Henry Ford Hospital Medical Journal

Three patients with hypothyroidism of 15-48 months' duration developed Graves' disease while on thyroid hormone replacement therapy. In one patient, the hyperthyrold phase was preceded by ophthalmopathy and nonsuppresslble 24-hour radioactive iodine uptake (RAIU). Eventually, all had hyperthyrold findings with elevated thyroid hormone levels, high 24-hour RAIU, and a diffuse uniform uptake of RAI by the enlarged thyroid. All subjects had negative antithyroglobulin and antimicrosomal antibody titers. Two had demonstrable long-acting thyroid stimulator (LATS) in their sera. All three were followed for 5-36 months while on propylthiouracil therapy prior to surgery or RAI administration. Both LATS-positive patients underwent bilateral subtotal …

Insulin-Resistant Diabetes Mellitus And Insulin Receptor Antibodies: Variable Association With Acanthosis Nigricans, José Goldman

Henry Ford Hospital Medical Journal

Two patients with severe insulin-resistant diabetes mellitus and anti-insulin receptor autoantibodies are reported here. A marked decrease in the number of accessible insulin receptors was found in the monocytes of one patient. Otherwise, the Insulin receptors were of normal affinity compared to those of normal controls. Acanthosis nigricans was not present in one patient, and in the other patient it preceded the diagnosis of diabetes by ten years. We conclude that although acanthosis nigricans and insulin resistance are frequently associated, they probably do not bear a pathogenetic relationship to each other. Therefore, the investigation of anti-insulin receptor antibodies Is advisable …

Dietary And Hormonal Factors In Bone Loss, Richmond W. Smith Jr.

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Black Lung Benefit Trusts As A Federal Self-Insurance Alternative, Peter M. Kelly

West Virginia Law Review

Since the enactment of the Federal Coal Mine Health and Safety Act1 (FCMHSA) in late 1969, occupational pneumoconiosis, "black lung disease," has been compensable under federal law. These federal black lung benefits are coordinated with state workmen's compensation or occupational disease laws to provide death or disability benefits for coal miners suffering from the disease. Black lung benefits are provided at federal cost under Part B of Title IV of the FCMHSA with respect to claims which arose before July 1, 1973 (Part B benefits)." Benefits are payable directly or indirectly by coal mine operators under Part C of Title …

Lipoprotein Lipase Inhibitor Removal During Ultrafiltration Of Renal Failure Patients, Alisa Minear

Loma Linda University Electronic Theses, Dissertations & Projects

Plasma samples were obtained from seven hypertriglyceridemic (>150 mg/dl) chronic renal failure patients before and after regular hemodialysis. The effect of the plasma on the lipolytic activity of bovine milk lipoprotein lipase was investigated. The lipoprotein lipase activity, as measured by release of C¹⁴-labeled free fatty acid from triglyceride, was decreased 8-67% when incubated with uremic plasma as compared to the control plasma (44 mg/dl triglyceride). The inhibition noted prior to hemodialysis did not appear to be alleviated by the dialysis but subsequent treatment with an isolated ultrafiltration technique did appear to remove an inhibitory substance as …

Review Of Prognostic Factors For Esophageal Voice, Christine G. Bravos

Loma Linda University Electronic Theses, Dissertations & Projects

Plan A of this study was completed. Plan B of the study is the subject for future research. A review of the laryngectomy literature, from the earliest mention of the laryngectomy surgical procedure to the present was conducted; with specific emphasis upon factors pertinent to laryngectomee rehabilitation and esophageal speech development. Psychological, idiosyncratic, social, therapeutic and physiological factors were reported as affecting esophageal voice development. There were a great diversity of variables that might be predictive in judging acquisition of esophageal voice. However, much of the information regarding predictive variables was based on subjective reports, poorly controlled statistical research, or …

An Ultra-Violet Light Microscopic Study Of The Hydroxylapatite Ceramic-Bone Interface Phenomena, Leonard W. Pierce

Loma Linda University Electronic Theses, Dissertations & Projects

Preparations used in this study were obtained from an investigation which had undertaken the following:

Durapatite, a hydroxylapatite ceramic was implanted in 24 mature Beagle dogs to study its maintenance effect on the alveolar bone of the mandible.

After dividing the dogs into two groups, a fresh socket and a healed socket group, the posterior teeth were removed and alveolectomies were performed. Eight ceramic implants were then placed in the right mandible of each animal in each group. The healed group received the implants five weeks after tooth removal and the fresh socket group received implants immediately after extraction.

The …

An Analysis Of The Attitudes Of Unlicensed Personnel In San Bernardino Metropolitan Area Convalescent Hospitals Toward Their Jobs And The Geriatric Patients, Theodore G. Sneed

Loma Linda University Electronic Theses, Dissertations & Projects

In American society, convalescent facility residency is a fact of life for many of the aged. Typically, in these geriatric facilities, eighty to ninety percent of primary patient care services are delivered by unlicensed personnel. Unfortunately, this segment of the convalescent facility employee population tends to be transient, underpaid and overworked, and to feel very low esteem for themselves and their jobs. This situation has produced many service abuses and interaction difficulties in the convalescent facilities. Up until the present there has been little attempt on the part of Sociology to study this portion of the employee population in these …

Commencement Program 1980-A (School Of Medicine), Loma Linda University

Commencement Programs

CONTENTS

2 | The Mace

3 | The Academic Procession

4 | Conferring of Degrees

6 | Graduates

7 | Awards

9 | 1980 Events of Commencement

10 | Declaration of Geneva

Toxicity Of Root Canal Filling Materials On Hela Cells And Fibroblasts, Eldon P. Carman

Loma Linda University Electronic Theses, Dissertations & Projects

A study was undertaken to determine the concentration at which a sealer reaches a point of nontoxicity. An in vitro model utilizing HeLa cells and human fibroblasts was used to observe the effect of various concentrations of eight freshly mixed and eight set root canal sealers. Evaluation of toxicity was determined by cell survival which was measured by incorporation of ³H-thymidine into the nucleic acid components of each cell type used. Each dilution tested was allowed direct contact with the cells for 24 hours before toxicity evaluation. The results indicate that all sealers at concentrations presently used are cytotoxic …

Public School Physical Therapists: Role Definition And Educational Needs, Pamela Levangie

All PTHMS Faculty Publications

Questionnaires returned by 328 physical therapists were analyzed to 1) establish a role definition for public school therapists and 2) determine the educational needs of therapists preparing for public school service. The therapists ranked 15 skills in importance to the role of the public school physical therapist and in urgency of their need to develop each skill. They also indicated which educational format they believed would be most appropriate for developing each skill. The respondents were divided into four groups matched by experience in treating children and by exposure to public school physical therapy. Rank-order correlations within each of these …

Dr. Hielema On Christian Counselling, Charles Claus

Pro Rege

No abstract provided.

Evaluation Of New Attachment Following Full Thickness Flap Procedure In Humans, Shaunda S. Steiner

Loma Linda University Electronic Theses, Dissertations & Projects

A study was made to investigate the biological possibility of obtaining new connective tissue attachment to periodontally diseased root surfaces following full thickness flap procedure. Reconstructive surgery was performed on seven teeth involved in advanced chronic periodontal disease. A mucoperiosteal flap was raised and the apical extent of existing subgingival calculus was marked with a notch made into the root just apical to the calculus. Following thorough instrumentation, sterile saline was applied to the root surface for five minutes, and the flap was repositioned and sutured. Four months later the teeth with attached periodontal tissues were removed and processed for …

Case Studies Of The Effects Of Orienting Stimuli On The Electroencephalogram And Levels Of Coma, Ina Muderspach, Marcia Swanson

Loma Linda University Electronic Theses, Dissertations & Projects

A comatose patient has long been a problem for nurses. Even though this problem has been recognized, very few studies have been conducted by the nursing profession to determine the best course of treatment for these patients. The physical care of the comatose patient has been dealt with in many nursing texts; in contrast, that portion of the care which the nurse could direct to the arousal of the comatose patient has not been documented.

The purpose of this study was to assess the effect of orienting stimuli on the individual level of consciousness as measured by Glasgow Coma Scale …

Third Molar Eruption Prediction: A Simplified Method, Lawrence E. Mcewen

Loma Linda University Electronic Theses, Dissertations & Projects

With the advent of lower third molar enucleation in the 7 to 10 year old comes the potential for abuse because the operation is fast and easy to perform. The rationale could be, "they will probably impact any way." If this is done without benefit of a growth forecast to project future dental needs a great disservice may be performed.

This study was designed to provide a simplified method to predict space for the lower third molar. Frankfort Horizontal (FH), Pterygoid Root Vertical (PTV), Xi, Upper first molar and lower second molar were the major landmarks to be used on …

Methodology In Measurement Of Load Loss Or Gain In Orthodontic Wires : A Pilot Study, Merton S. Lacy

Loma Linda University Electronic Theses, Dissertations & Projects

The purpose of this investigation was to develop methods and equipment to measure and record over any desired length of time the loss or gain in force of any material used in orthodontics that can produce a force upon an object. The material and the object being acted upon should not be disturbed while measuring that force.

Holding devices were designed and constructed in two basic forms. For intrusive and extrusive type forces, a load cell was fixed horizontally in such a position that an adjustable tube with a set screw to hold the wire could be rotated to cause …

Changes Of The Marginal Periodontium As A Result Of Labial Tooth Movement In Monkeys, Gregory G. Steiner, J. K. Pearson, J. Ainamo

Loma Linda University Electronic Theses, Dissertations & Projects

Orthodontic tooth movement was performed on five monkeys (Macaca nemistrina). Oral health was established and exploratory surgery was performed to assess the level of the connective tissue attachment and marginal bone. Measurements of the gingival margin and mucogingival junction were taken and orthodontic forces were applied. The central incisors were moved labially a mean distance of 3.05mm. Post therapy measurements were performed to assess the change which occurred as a result of tooth movement. Significant recession of the gingival margin, connective tissue level and marginal bone was found when compared to an amalgam marker located on the facial surface of …

Marginal Periodontium Changes In The Monkey (Macaca Nemestrina) Following Incisor Repositioning From A Mechanically Positioned Labioversion, Gary Engelking

Loma Linda University Electronic Theses, Dissertations & Projects

The anterior teeth of five adult pigtail monkeys were moved lingually to correct a previously induced labioversion. These teeth were retained in their more normal arch positions for five months, after which clinical and histologic measurements were made of the periodontium. The untreated cuspids served as controls. Measurements were made to record changes in the gingival margin, the mucogingival junction, the width of keratinized gingiva and the marginal bone level relative to a fixed point on the tooth crowns. Oxytetracycline was administered three times to label areas of osteogenesis in the periodontium.

The incisors were retracted a mean distance of …

Orthognathic Surgical Expansion Procedure Of The Mandible Of Female Baboon Papio Sp?, Willis L. Schlenker

Loma Linda University Electronic Theses, Dissertations & Projects

Expansion of the maxillae is a well recognized procedure in orthodontics. Little is known about Mandibular Expansion. This project is a pure research of the possibility of expanding the mandible laterally at the symphysis on a baboon.

The symphysis was cut A-P and expanded laterally 11 mm, then held and stabilized with a titanium mesh work screwed to the inferior border of the mandible. The defect area was filled with a bone graft of marrow and cancellous bone fragments taken from the greater trochanter and the crest of the ilium. New bone did fill in the defect and the expansion …

การระบาดของโรค Aujeszky's Disease ในสุกร (Recent Outbreaks Of Aujeszky's Disease In Pigs With Particular Reference To Laboratory Diagnosis Of Clinical Cases), บุญมี สัญญสุจจารี, สละ กองสมัคร, พิเคราะห์ อาจทรงคุณ

The Thai Journal of Veterinary Medicine

ตั้งแต่เดือนธันวาคม พ.ศ. 2520 เป็นต้นมา ภาควิชาพยาธิวิทยา คณะสัตวแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย ได้พิสูจน์โรค Aujeszky's Disease สุกรซึ่งเกิดระบาดขึ้นเป็นจำนวน 6 ครั้ง โดยใช้การพิสูจน์โรคหลายวิธี และพบว่าวิธี ฟลูออเรสเซนท์แอนติบอดี้เทสท์จาก impression smears ของสมองและ cryostat sections จากทอนซีลให้ผลรวดเร็วและมีความแม่นยําสูง เหมาะที่จะใช้ในกรณีที่เกิด โรคระบาด เพราะสามารถนำผลไปใช้ในการวางแผนป้องกัน และควบคุมโรคได้ทันท่วงที การศึกษาจุลพยาธิวิทยาของสมอง ทอนซิลและอวัยวะอื่น ๆ ของลูกสุกรป่วย และ การฉีดเชื้อไวรัสเข้าใต้ผิวหนังกระต่าย ถึงแม้จะใช้เวลาในการปฏิบัติมากกว่าแต่เป็น การปฏิบัติที่ได้ผลและเป็นการสนับสนุนผลทางฟลูออเรสเซนท์แอนติบอดี้เทสท์ได้เป็นอย่าง ดี ในการศึกษาครั้งนี้พบว่าลูกสุกรป่วย (อายุ 3-15 วัน) จำนวน 21 ใน 22 ตัว จาก การระบาดทั้ง 6 ครั้งมีการอักเสบของสมองแบบ non-suppurative encephalitis และพบ Cowdry type A intranuclear inclusion bodies ในเซลล์ประสาท และ glial cells ด้วย และพบหย่อมเนื้อตาย (focal necrosis) ที่ตับ ปอด ต่อมน้ําเหลือง ม้าม ทอนซิล ซึ่งหย่อมเนื้อตายเหล่านี้เกี่ยวข้องกับ intranuclear inclusion bodies ในการฉีดเชื้อไวรัสเข้ากระต่าย จะเกิดอาการคันมาก (intense pruritus) หลังจากฉีด 2-4 วัน อาการป่วยที่สำคัญของสุกรที่เป็นโรคนี้จาก ทั้ง 6 ครั้งคืออาการทางประสาท อาการทางระบบหายใจ และพบว่าสุกรที่กำลังท้อง มีอัตราการแท้งสูงในช่วงเวลาที่มีการระบาด

การแยกเชื้อ Aujeszky's Disease Virus โดยใช้เซลล์คัลเจอร์ (Isolation And Identification Of Aujeszky"S Disease Virus By Using Cell Culture), สละ กองสมัคร, บุญมี สัญญสุจจารี, พิเคราะห์ อาจทรงคุณ

The Thai Journal of Veterinary Medicine

Aujeszky's Disease virus แยกได้จากสมองของสุกรที่ตายด้วย โรคที่ส่งสัยว่าเป็น Aujeszky's Disease โดยใช้ PK-15 cell line. ซึ่งต่อมาได้ทําการพิสูจน์โดยใช้วิธีฟลูออเรสเซนท์แอนติบอดี้ยเทสท์และไวรัสนอยทราลไลเซชั่น เทสท์ และยืนยันได้ว่ามีโรค Aujeszky's Disease ระบาดอยู่ในสุกรในประเทศไทย

รายงานสัตว์ป่วย : ความสูญเสียทางเศรษฐกิจเนื่องจากโรคแท้งติดต่อในสุกรในจังหวัดราชบุรี (Losses Due To Brucellosis Outbreak In A Pig Breeding Farm In Rajburi Province), อรรณพ คุณวงษ์กฤติ, ชัยณรงค์ โลหชิต, พีระศักดิ์ จันทร์ประทีป

The Thai Journal of Veterinary Medicine

ฟาร์มเลี้ยงสุกรฟาร์มหนึ่งตั้งอยู่ในท้องที่ จังหวัดราชบุรี มีปัญหาการผสมติดยาก (35%) แท้งลูก (24.40%) และลูกสู่กรที่คลอดออกมาไม่แข็งแรงทําการ ตรวจโรคแท้งติดต่อทาง Seroagglutination test พบว่าสุกรในฟาร์มเป็นโรคนี้ ถึง 72.09% จากสุกรทั้งหมด 86 ตัวจึงได้คัดสุกรเหล่านี้ออกจากฝูง

Short Communications, N/A

The Thai Journal of Veterinary Medicine

No abstract provided.