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Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes

All ETDs from UAB

Bacillus anthracis (Ba) is a Gram,-positive zoonotic bacterium that causes inhala- tional, cutaneous and intestinal Anthrax Disease. Although the infectious form of Ba is its endospore (spore), only the tripartite toxin-producing vegetative bacteria causes disease pathology. While current vaccination strategies target the Protective Antigen (PA) com- ponent of this toxin, vaccine-elicited immunity to the spore form of Ba is lacking. How- ever, vaccines targeting spore components of Ba have the potential to neutralize the in- fectious form of Ba. We sought to determine if antibodies elicited through immunization with the main antigenic component of the spore surface- Bacillus collagen-like protein …

Looking At Levels Of Medicalization In The Institutional Narrative Of Substance Use Disorders In The Military, Chase Landes Mccain

USF Tampa Graduate Theses and Dissertations

The purpose of this research is to examine the institutional narrative of substance use disorders (SUDs) in the U.S. military and the extent to which it reflects the medicalization process. Three general research questions guided my analysis of the narrative surrounding SUDs in the military: (1) How does the military characterize the problems and resolutions of SUDs? (2) How and to what extent does this narrative reflect medicalization? (3) What are the limitations inherent in the institutional narrative of SUDs in the military? In order to address these questions, I draw on three conceptual lenses: (1) The work of Loseke …

Target Definition For Shipwreck Hunting, Kim Kirsner

Medical Papers and Journal Articles

The research described in the present article was implemented to define the locations of two World War II shipwrecks, the German raider Kormoran, and the Australian light cruiser HMAS Sydney. The paper describes the long and complex trail that led through inefficient oceanographic prediction to ambiguous historical prediction involving a single report and on to precise cognitive prediction based on nine reports from more than 70 survivors, a process that yielded a single target position or “mean” just 2.7NM (nautical miles) from the wreck of Kormoran. Prediction for the position of the wreck of Sydney opened with wishful thinking that …

Chronic Behavioral And Cognitive Deficits In A Rat Survival Model Of Organophosphate Toxicity, Beverly Huang

Theses and Dissertations

Organophosphates (OPs) are a major class of pesticides and nerve agents that elicit acute toxicity by inhibiting acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine in the central and peripheral nervous systems. Acetylcholine accumulation following extensive AChE inhibition leads to an acute cholinergic syndrome characterized by autonomic dysfunction, involuntary movements, muscle fasciculations, respiratory distress, and seizures. Despite their classification as moderate to highly toxic, OP pesticides are the most widely used class of insecticides in the U.S., and are even more commonly used worldwide. Additionally, there is a growing concern that OP nerve agents could be …

Slavery, Agriculture, And Malaria In The Arabian Peninsula, Benjamin Reilly

Ohio University Press Open Access Books

In Slavery, Agriculture, and Malaria in the Arabian Peninsula, Benjamin Reilly illuminates a previously unstudied phenomenon: the large-scale employment of people of African ancestry as slaves in agricultural oases within the Arabian Peninsula. The key to understanding this unusual system, Reilly argues, is the prevalence of malaria within Arabian Peninsula oases and drainage basins, which rendered agricultural lands in Arabia extremely unhealthy for people without genetic or acquired resistance to malarial fevers. In this way, Arabian slave agriculture had unexpected similarities to slavery as practiced in the Caribbean and Brazil.

This book synthesizes for the first time a body of …

The Felt Sense Of Interconnectedness: A Qualitative Analysis Of Perceptions On Finding Resilience In The Aftermath Of Trauma Using The Mind-Body Connections Of Yoga, Ashley Collette

Theses and Dissertations (Comprehensive)

Members and veterans of the military are at an increased risk of exposure to traumatic experiences due to the very nature of their occupation. The most recent statistics on Canada’s deployment to Afghanistan show that 13.2% of the (Canadian Armed Forces (CAF) members deployed have been diagnosed with a mental injury within a five year follow up period of redeployment from the theatre of operations. The present preliminary study was designed to examine Yoga as a therapeutic intervention for trauma in a population of CAF members and veterans. The author interviewed 4 service providers and 2 service users of Yoga-based …

Ms171: Interview With Margaret Kripke, Margaret Kripke Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral history interview with Margaret Kripke. See more at Texas Medical Center-Women's History Project and its finding aid.

The Ethics Of Animal Research: A Survey Of Pediatric Health Care Workers, Ari Joffe, Meredith Bara, Natalie Anton, Nathan Nobis

Experimentation Collection

Introduction: Pediatric health care workers (HCW) often perform, promote, and advocate use of public funds for animal research (AR). We aim to determine whether HCW consider common arguments (and counterarguments) in support (or not) of AR convincing.

Design: After development and validation, an e-mail survey was sent to all pediatricians and pediatric intensive care unit nurses and respiratory therapists (RTs) affiliated with a Canadian University. We presented questions about demographics, support for AR, and common arguments (with their counterarguments) to justify the moral permissibility (or not) of AR. Responses are reported using standard tabulations. Responses of pediatricians and nurses/RTs were …

The End Of An Era: The Cancer Stem Cell Hypothesis And Its Therapeutic Implications, Emily Paton

Independent Study Project (ISP) Collection

Cancer, a leading cause of death in many developed countries, has become a global health burden. Much of the drain on healthcare systems has resulted from the high cost and ineffectiveness of conventional cancer treatments, which often lead to cancer relapse or metastasis. The failures of chemotherapy, radiation, and surgery have been elucidated by the cancer stem cell (CSC) hypothesis, which postulates that a small percentage of tumor cells drive tumorigenesis. These cells can sustain cancer through their capacity to self-renew and differentiate into specialized tumor cell types, similar to how healthy stem cells maintain healthy tissues. Conventional cancer treatments …

New Onset Refractory Status Epilepticus As An Unusual Presentation Of A Suspected Organophosphate Poisoning, Shahan Waheed, Amber Sabeen, Nadeem Ullah Khan

Department of Medicine

New onset refractory status epilepticus (NORSE) is a new entity in medical literature. It has different infectious and noninfectious etiologies showing a devastating impact onto the clinical outcome of patients. Therapy with anaesthetic and antiepileptic agents often fails to improve the condition, unless the primary cause is rectified. Here is presented the case of a young female with a history of depression who after a recent bereavement came to the Emergency Department of Aga Khan University Hospital with complaints of drowsiness that lasted for few hours. Though she had no history of organophosphate poisoning, her physical examination and further investigations …

Genotypes Frequencies Of Rs9923231 And Rs7294 Snps In The Vkorci Gene Among Emiratis And Their Implications For Warfarin Dosage, Hayat Saad Al-Jaibeji

Theses

Warfarin is the most commonly used oral anticoagulant medication given as a prophylaxis and/or treatment of venous and arterial thromboembolic disorders. Warfarin doses vary up to 10-fold among patients due to pharmacokinetics, pharmacodynamics and pharmacogenomics factors. In addition, Warfarin has a low therapeutic index with the risk of developing serious side effects such as severe bleeding or failure of therapy. Therefore, the main challenge to achieve the therapeutic goal in warfarin treatment is estimating the appropriate dose for each patient. It is estimated that pharmacogenomics factors contribute to more than 60% of dose variability. The gene encoding for the target …

Disaster Preparedness & Response: A Survey Of U.S. Dental Hygienists, Brenda Tallon Bradshaw

Dental Hygiene Theses & Dissertations

Purpose: The purpose of this study was to determine dental hygienists' interests, formal education, views, comfort levels, and intentions for becoming involved in disaster preparedness and response as measured by a 21-item survey entitled "Victim Identification for Disaster Preparedness & Response: A Survey of Dental Hygienists". Methods: A nonprobability convenience sample (n=400) was recruited for an online survey. Data was analyzed for statistical significance using descriptive statistics, chisquare goodness-of-fit tests, a Mann-Whitney U test, and a paired-samples t-test. Similar themes were identified and categorized from open-ended questions. Results: A response rate of 83.5% (n=334) was attained. Regardless of years …

Agency Of The South Sudanese: Compensating For Health Care In Mungula Refugee Settlement, Lauren Schmidt

Independent Study Project (ISP) Collection

In reaction to the endemic violence, which has forced many South Sudanese to flee their homes and seek refuge within Uganda’s borders, the researcher spent the practicum interning with the Uganda Red Cross Society (URCS) in Mungula refugee settlement, under academic advisor Steven Mawa. As the organization is the leading health provider in the settlement, the researcher gained insight into the provision of social services to the population, which allowed an extensive study on the ability of the South Sudanese to compensate for shortages in care and various complications associated with doing so.

The researcher sought to entertain these inquiries …

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo F. Larsen, William H. Velander, Mark A. Carlson

William H. Velander Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury types …

Can Anyone With Low Income Be Food Secure?: Mitigating Food Insecurity Among Low Income Households With Children In The Tampa Bay Area, Edgar Allan Amador

USF Tampa Graduate Theses and Dissertations

In the US over the last few years, approximately 14.5% of households experience food insecurity at some point throughout the year. While studies on food insecurity in the US have determined that household income and specifically income available to spend on food is of critical importance to food security, it is still unclear why some households with low income are able to maintain food security while others experience food insecurity in a pattern characterized as not constant but recurrent. This dissertation compares households with children at different levels of food security and insecurity using the USDA Core Food Security Module …

When Harvard Said No To Eugenics: The J. Ewing Mears Bequest, 1927, Paul A. Lombardo

Faculty Publications By Year

James Ewing Mears (1838-1919) was a founding member of the Philadelphia Academy of Surgery. His 1910 book, The Problem of Race Betterment, laid the groundwork for later authors to explore the uses of surgical sterilization as a eugenic measure. Mears left $60,000 in his will to Harvard University to support the teaching of eugenics. Although numerous eugenic activists were on the Harvard faculty, and who of its Presidents were also associated with the eugenics movement, Harvard refused the Mears gift. The bequest was eventually awarded to Jefferson Medical College in Philadelphia. This article explains why Harvard turned its back …

A Review Of Animal Studies For The Efficacy Of D-Methionine In Reducing Threshold Shifts And Affecting Biochemical Changes After Exposure To Noise, Alexandra Petraru

Dissertations, Theses, and Capstone Projects

Noise induced hearing loss (NIHL) is a major public health concern in the United States and worldwide. Certain individuals such as factory workers and military personnel are at greatest risk for irreversible sensorineural hearing loss due to the limitations of hearing protection measures and devices. D-Methionine (d-Met) is an antioxidant otoprotective agent that currently is in human clinical trials. The purpose of this systematic literature review was to review d-Met’s efficacy in reducing threshold shifts as well as in producing biochemical and physical changes in animal studies vis-à-vis the administration paradigm (preloading, rescue and a combined approach), d-Met dose quantity …

From Sea To Shining Sea: Force Health Management Of Infectious Diseases In A Cross-Global Deployment Flux Toward Tropical Environments, Joanna M. Nelms

Master of Public Health Program Student Publications

Infectious diseases in fighting armies are a pestilence as old as war itself. The history of the United States military is rich in successes of innovation and lessons learned in failure in the prevention and treatment of infectious diseases. Over the nearly two and a half centuries of American warfare, military research and development have contributed greatly to advancements in vaccines, medical treatments, and other control and prevention strategies for tropical and other infectious diseases. Current deployments in desert environments have provided continued research and progress in infectious disease control, treatment, and prevention, despite a relative decrease in civilian medical …

Bridging The Gap: Understanding, Anticipating, And Responding To The Needs Of Student Veterans In A Bachelor Of Science In Nursing Program, Larry Michael Stowers

Doctoral Projects

The passage of the Americans with Disabilities Act Amendment Act (ADAAA) of 2008 and the Post-9/11 Veterans Assistance Act of 2008 have afforded veterans the opportunity to pursue post-secondary education. Since October 2001, over 2 million American men and women in uniform have deployed in support of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF). While thousands of returning combat veterans take advantage of recent legislation that helps pay for their education, they face new challenges in the classroom. This nation’s veterans represent a group of diverse individuals who bring different experiences, thus different perspectives than traditional college-aged students. …

Best Integrated Writing 2014 - Complete Edition

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University. The journal is published annually by the Wright State University Department of English Language and Literatures.

Combat Paper Project, William Joiner Institute For The Study Of War And Social Consequences, University Of Massachusetts Boston

Office of Community Partnerships Posters

Coming home from war is enormously difficult. A new language is required to express the magnitude of war’s effects and consequences. Combat Paper transforms the uniforms of battle to paper and from this transformation comes art. Developed by veterans of Iraq and Afghanistan in San Francisco, the project has now traveled broadly across the United States and the world.

Narco-Trauma: The Phenomenology Of The Mexican Drug War Among Binational Students At The Border, Kathleen A. O'Connor

Nursing Faculty Publications

In this article, I present research conducted among 242 university students living in the binational metropolitan area encompassing El Paso, Texas, and Ciudad Juárez, Mexico, that has been affected by drug violence. The particular focus is on narratives of social suffering and lived experience in the context of drug violence.

Program And Proceedings: Nebraska Academy Of Sciences 1880–2014, 134th Anniversary Year, One Hundred-Twenty-Fourth Annual Meeting, April 11, 2014

Nebraska Academy of Sciences: Programs and Proceedings

Program

Aeronautics and Space Science

Collegiate Academy: Biology

Chemistry and Physics

Collegiate Academy: Chemistry and Physics

Applied Science and Technology

Biological and Medical Sciences

Aeronautics and Space Science, Poster Session

Anthropology

Maiben Memorial Lecture: "Education, Careers and Opportunities in Engineering and Metallurgy in Nebraska," Terry Rasmussen, Nucor Steel, Norfolk, Nebraska

Teaching of Science and Mathematics

Anthropology

Earth Science

Trends Of The Portrayal Of Yahweh In The Hebrew Bible, Kenneth Price

Best Integrated Writing

Kenneth Price explores trends of the portrayal of Yahweh in the Hebrew bible in this essay written for the Integrated Writing course ENG 2040: Great Books, Bible and Western Culture, taught by Dr. Heidi Wendt at Wright State University.

Man To Man: Perspectives On Being The Father Of A Very-Low-Birth-Weight Infant Through Interpretive Phenomenology, Donald A. Johnston

Nursing Theses and Dissertations

While volumes of literature lend insight into the experience of being a mother in the NICU, the experience of fathering a neonate remains vastly understudied. The goal of this hermeneutical phenomenological study was to explore the lived experience of eleven fathers of very low birth weight infants during their infants' stay in a neonatal intensive care unit. In-depth interviews were semi-structured, digitally recorded and transcribed verbatim. Data were analyzed using Max van Manen's methodology, along with a metaphorical illustration to illuminate meanings of experiences. Analysis was structured using Heidegger's philosophical concepts of Being-in-the-world and Being-with-others, as well as the added …

The Santa Clara, 2014-01-30, Santa Clara University

The Santa Clara

No abstract provided.

Predicting The Risk Of Suicide By Analyzing The Text Of Clinical Notes, Chris Poulin, Brian Shiner, Paul Thompson, Linas Vepstas, Yinong Young-Xu, Benjamin Goertzel, Bradley Watts, Laura Flashman, Thomas Mcallister

Dartmouth Scholarship

We developed linguistics-driven prediction models to estimate the risk of suicide. These models were generated from unstructured clinical notes taken from a national sample of U.S. Veterans Administration (VA) medical records. We created three matched cohorts: veterans who committed suicide, veterans who used mental health services and did not commit suicide, and veterans who did not use mental health services and did not commit suicide during the observation period (n = 70 in each group). From the clinical notes, we generated datasets of single keywords and multi-word phrases, and constructed prediction models using a machine-learning algorithm based on a …

Effects Of Body Armor And Load Carriage On Lower Limb Joint Movement, Huiju Park, Donna Branson, Adriana Petrova, Semra Peksoz, Carla Goad, Aric J. Warren, Bert Jacobson, Panagiotis Kamenidis

Journal of Human Performance in Extreme Environments

This study investigated the impact of body armor weight and load magnitude and distribution on the lower extremities during walking. Range of motion (ROM) was assessed while seven healthy, male, right-handed, military university students walked while wearing seven different garments of varying weights (0.06 kg, 9 kg, 18 kg, and 27 kg) and load distributions. Decreased pelvic rotation found with an increase in weight implies decreased mobility by restricting the leg’s swing to propel the body forward. Increased ROM for pelvic tilt found with increased weight results from increased forward inclination suggesting an increased possibility for fatigue and musculoskeletal pain …

Chronic Behavioral And Cognitive Deficits In A Rat Survival Model Of Paraoxon Toxicity, Laxmikant Sudhir Deshpande, Kristin Phillips, Beverly Huang, Robert J. Delorenzo

Neurology Publications

Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities. We have developed a rodent survival model of POX toxicity that is being used to evaluate chronic morbidity and to screen for medical countermeasures against severe OP exposure. It is well known that the survivors of nerve gas and chronic OP exposure exhibit neurobehavioral deficits such as mood changes, depression, and memory impairments. In this study we investigated whether animals surviving severe POX exposure exhibited long-term neurological impairments. POX exposure …

Development Of Status Epilepticus, Sustained Calcium Elevations And Neuronal Injury In A Rat Survival Model Of Lethal Paraoxon Intoxication, Laxmikant Sudhir Deshpande, Dawn S. Carter, Kristin Phillips, Robert E. Blair, Robert J. Delorenzo

Neurology Publications

Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality. OP poisoning is often associated with chronic neurological disorders. In this study, we optimize a rat survival model of lethal POX exposures in order to mimic both acute and long-term effects of POX intoxication. Male Sprague–Dawley rats injected with POX (4 mg/kg, ice-cold PBS, s.c.) produced a rapid cholinergic crisis that evolved into status epilepticus (SE) and death within 6–8 min. The EEG profile for POX induced SE was characterized and showed clinical and …