Digital Commons Network^™

Structural Disruption Of The Blood–Brain Barrier In Repetitive Primary Blast Injury, Gozde Uzunalli, Seth Herr, Alexandra M. Dieterly, Riyi Shi, L. Tiffany Lyle

Purdue University Libraries Open Access Publishing Fund

Background

Blast-induced traumatic brain injury (bTBI) is a growing health concern due to the increased use of low-cost improvised explosive devices in modern warfare. Mild blast exposures are common amongst military personnel; however, these women and men typically do not have adequate recovery time from their injuries due to the transient nature of behavioral symptoms. bTBI has been linked to heterogeneous neuropathology, including brain edema, neuronal degeneration and cognitive abnormalities depending on the intensity of blast overpressure and frequency. Recent studies have reported heterogeneity in blood–brain barrier (BBB) permeability following blast injury. There still remains a limited understanding of the …

A Timecourse Based Dermatotoxicity Evaluation Of Mechlorethamine On Damage And Repair Related Protein Expression In The Mouse Ear Vesicant Model, Ganming Mao

Theses and Dissertations

Mechlorethamine (HN2) is a type of nitrogen mustard alkylating agent that has been widely applied as an anticancer drug. HN2 is an analog of the corrosive reagent sulfur mustard, which is highly reactive with skin and organisms exposed to HN2 develop significant skin irritation, edema, erythema, and disruption of the dermal-epidermal junction (DEJ). These pathological affects lead to tissue damage, activate wound repair mechanisms and, if unresolved, result in necrosis. The purpose of the present study was to evaluate the time-dependent effects of HN2 on the expression of three different proteins using immunohistochemistry (IHC) and previously prepared and preserved formalin-fixed …

An Emergent Legionnaires' Disease Syndemic: Water Supply Systems, Infrastructural Violence, And Afflicted Lives In The South Bronx, Ny, Eduardo Piqueiras

Wayne State University Dissertations

This dissertation examines how contemporary approaches to Legionnaires’ disease (LD) narrowly view it as a biomedical entity that obscures critical moral, temporal, and contextual dimensions creating gaps in how LD “cases” are defined and mitigated. Those who receive an LD diagnosis experience many unique challenges (e.g., personal, existential, community-based, and environmental) yet little is known about how this group of individuals experience recovery and attach meaning to their individual experiences. Using an anthropological lens of illness and recovery and a syndemics view of infrastructural violence this study examines those inadequately addressed multiple dimensions which limit our ability to confront the …

Assessing Changes In The Epidemiology Of Cutaneous Leishmaniasis In Southwest Colombia Following The Peace Accord With Fuerzas Armadas Revolucionarias De Colombia (Farc), Matthew Stephen Benczkowski

Public Health Theses

The Colombian Conflict persisted for over 50 years, recently coming to an end in November 2016 after the signing of Colombia’s Peace Agreement between the government and FARC guerrilla group. Internal armed conflict is often entangled with the exacerbation of health outcomes, including promoting the spread of infectious diseases like cutaneous leishmaniasis (CL). CL is a vector-borne parasitic disease localized to the human tegument that decreases quality of life through lesions leading to scars and associated stigmatization. This study assessed changes in demographic and clinical characteristics of patients with CL in Southwest Colombia before and after the signing of the …

Relationship Between Media Coverage And Child Measles Vaccination Uptake, Tanika Ward

Walden Dissertations and Doctoral Studies

Childhood vaccines have been a source of heated debates between both opponents and proponents of vaccination. Childhood immunizations have proven to be effective and save lives, but antivaccine movements continue. The purpose of this retrospective cross-sectional quantitative study was to determine if there was a significant difference in child measles vaccine uptake based on provider facility type and census region, after adjusting for age and education of mother, for the years 2003–2012, pre-and-post 2007 media coverage deeming vaccines unsafe, and for the years 2013–2017, pre-and-post exposure to measles at Disneyland in 2014–2015 for children aged 19–35 months. The social ecological …

Towards A Holistic Risk Model For Safeguarding The Pharmaceutical Supply Chain: Capturing The Human-Induced Risk To Drug Quality, Heather R. Campbell

Theses and Dissertations--Pharmacy

Counterfeit, adulterated, and misbranded medicines in the pharmaceutical supply chain (PSC) are a critical problem. Regulators charged with safeguarding the supply chain are facing shrinking resources for inspections while concurrently facing increasing demands posed by new drug products being manufactured at more sites in the US and abroad. To mitigate risk, the University of Kentucky (UK) Central Pharmacy Drug Quality Study (DQS) tests injectable drugs dispensed within the UK hospital. Using FT-NIR spectrometry coupled with machine learning techniques the team identifies and flags potentially contaminated drugs for further testing and possible removal from the pharmacy. Teams like the DQS are …

Developing A Framework For Civilian-Military Public Health Operations Involving Non-State Armed Groups, Andrew James Chambers

Public Health Theses

Introduction: The interface of military forces, civilian actors and non-state armed groups (NSAGs) during a public health emergency within an active conflict is a situation fraught with legal and ethical challenges not adequately addressed in established doctrine or international guidance documents. Ongoing public health crises in Yemen and Afghanistan represent the real-world consequences of threats to population health and security if these critical gaps are not addressed. Methods: A list of five diverse medical scenarios was developed as an initial attempt to produce a practical, historically-informed framework for use in future civilian-military (CIV-MIL) training events and guidance. Ten virtual interviews …

Addressing The Ecological Fallacy With Lagrangian Inference, Michael Schwob

Calvert Undergraduate Research Awards

Most epidemiologists elect to use statistical models that use population-level data to make inference on the spread of some virus or disease. This has become commonplace in the fields of epidemiology and biostatistics since most data used to construct and verify epidemic models are recorded at the population-level. Obtaining inference from a population-level model may be beneficial in studying the spread of disease in a homogeneous population, but the use of such models to describe a heterogeneous population results in inadequate inference. The inaccuracy of these models is further amplified when one tries to make individual-level inference from these population-level …

Search Strategy For "Prevalence Of Adverse Childhood Experiences (Ace) Among Children And Adolescents In The U.S.: A Scoping Review", Kiara Lyons, Melissa Tibbits 5999447, Jennifer Hill, Kendra Schmid, Shinobu Watanabe-Galloway

Search Strategies: College of Public Health

No abstract provided.

Post-Conflict Mental Health Policy And Substance Use Among Liberian Adults, Ekua Amonoo-Lartson

Walden Dissertations and Doctoral Studies

AbstractThe objective of post-conflict countries after an extended period of war and trauma is to maintain peace and stability. However, the physical and psychological effects of substance use to cope with the devastation of war remains long after the crisis has ended. The purpose of this qualitative phenomenological study was to examine substance use among Liberian working-age adults, including their substance use habits, experiences with substance use, and access to mental health rehabilitative treatment. The access to medical care theoretical framework was used to guide the study. Data were collected from face-to-face semistructured interviews with 15 individuals regarding their experiences …

Matters Of Biocybersecurity With Consideration To Propaganda Outlets And Biological Agents, Xavier-Lewis Palmer, Ernestine Powell, Lucas Potter, Thaddeus Eze (Ed.), Lee Speakman (Ed.), Cyril Onwubiko (Ed.)

Electrical & Computer Engineering Faculty Publications

The modern era holds vast modalities in human data utilization. Within Biocybersecurity (BCS), categories of biological information, especially medical information transmitted online, can be viewed as pathways to destabilize organizations. Therefore, analysis of how the public, along with medical providers, process such data, and the methods by which false information, particularly propaganda, can be used to upset the flow of verified information to populations of medical professionals, is important for maintenance of public health. Herein, we discuss some interplay of BCS within the scope of propaganda and considerations for navigating the field.

Stress Inoculation Training (Sit-Norcal), Part 1: The Development And Preliminary Evaluation Of A Psychological Performance Training Protocol, Sarah E Jackson, Matthew R Baity, Patrick R Thomas, Douglas Barba, Daniel Jacobson, Madeleine Goodkind, Diane Swick, A Sarah Ivey

Faculty, Staff and Student Publications

Background: Stress inoculation training (SIT) interventions have demonstrated promise within military contexts for human performance enhancement and psychological health applications. However, lack of manualized guidance on core content selection, delivery, and measurement processes has limited their use.

Purpose: The purpose of this study was to develop and evaluate a comprehensive SIT intervention protocol to enhance the performance and health of military personnel engaged in special warfare and first-response activities.

Methods: Multidisciplinary teams of subject matter experts (n = 19) were consulted in protocol generation. The performance improvement/human performance technology (HPT) model was used in the selection, refinement, and measurement of …

Stress Inoculation Training (Sit-Norcal), Part 2: A Pilot Study Among Explosive Ordnance Disposal Special Warfare Enablers, Sarah E Jackson, Matthew R Baity, Patrick R Thomas, Mark Walker, Madeleine Goodkind, Diane Swick, Douglas Barba, Daniel Jacobson, Eric Byrd, A Sarah Ivey

Faculty, Staff and Student Publications

Background: Despite being a well-supported strategy, Stress Inoculation Training (SIT) has not been fully incorporated in the advancement of human performance among most military personnel. The RAND Study recommendations for maximizing SIT's potential within high-risk/ high-intensity occupational groups were used in designing the Core Training protocol targeting psychological performance, SIT-NORCAL (Part 1).

Purpose: The current project (Part 2) sought to further develop the protocol as a health and human performance hybrid through quality improvement analysis of the content, process, and measurement elements for use in the human performance context.

Methods: Evidence-based/evidence-driven methodologies were used in collaborative design tailored to the …

From Military Service To Diakonia: A Training Program For Clergy Ministering To Veterans, Danielle Xanthos

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Many veterans opt to seek the support of clergy before mental health professionals. Most clergy, however, are unfamiliar with the nuances of the veteran culture and experience. Mental health professionals who specialize in working with the veteran population can collaborate with clergy to bridge this gap of care to mutually develop a better understanding of veteran culture and symptoms of mental health conditions common among the veteran population, and by equipping clergy with basic tools that promote psychological and spiritual wellbeing. Special consideration is given to the concept of moral injury and the application of Acceptance and Commitment Therapy, illustrating …

Development Of A Breech-Specific Integrated Care Pathway For Pregnant Women: Protocol For A Mixed Methods Study, Sara Morris, Sadie Geraghty, Deborah Sundin

Research outputs 2014 to 2021

Background: The development of an integrated care pathway with multidisciplinary input to standardize and streamline care for pregnant women experiencing breech presentation at 36 or more weeks of gestation poses several challenges because of the divisive and contentious nature of the phenomenon. Although many clinicians are interested in obtaining the skills required to safely support women desiring a vaginal breech birth, the primary trend in most health care facilities is to recommend a cesarean section. Objective: This paper aims to discuss the mixed methods approach used in a doctoral study conducted to generate new knowledge regarding women’s experiences of breech …

Communication Surrounding Initiation And Withdrawal Of Non-Invasive Ventilation In Adults With Motor Neuron(E) Disease: Clinicians’ And Family Members’ Perspectives, Charlotte Chapman, Sara Bayes, Moira Sim

Research outputs 2014 to 2021

Introduction: International guidelines recommend that health care clinicians communicate with people with MND and their family members about non-invasive ventilation (NIV) and percutaneous gastrostomy tube (PEG) prior to or at the onset of respiratory symptoms. This study sought to discover the degree to which these recommendations are followed in practice.

Methods: Interpretive Description methodology was employed. Nineteen clinicians experienced in caring for people with MND, six relatives of recently deceased people with MND and one person with MND participated in semi-structured in-depth interviews. Clinicians’ accounts of NIV and PEG related communications were compared to family member participants’ recollections of their …

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …

Botox Injection To Treat Strabismus After Infant Botulism Type B Infection, Sarah G Bonaffini, Victoria Cocozza, Jing Jin

Ophthalmology Resident Research

Purpose: The significance of botulinum toxin to ophthalmologists is twofold. Botulism, a medical emergency, frequently presents with ocular findings including blurred vision, diplopia, ptosis, and photophobia as a result of the neurotoxin produced by Clostridium botulinum. However, botulinum toxins also have therapeutic uses for medical conditions including strabismus. The safety and efficacy of Botulinum toxin A in patients with a history of botulism has not been reported.

Observations: We report a 9-week-old infant, diagnosed with type B toxin positive infant botulism treated with human botulism immune globulin, who developed a large angle exotropia. The infant was treated with intramuscular injections …

Innovator - Fall 2016

Innovator

4 - What’s Now: Impact Edition

6 - Building the Futures Center

9 - Snapshots of Impact

12 - The Six Steps to Success

16 - On Common Ground

18 - Opening the Door of Opportunity

20 - A Team Effort

24 - The Clash of Tradition and Technology

26 - Enriching the Student Experience

27 - Who Named the Rams?

27 - Financial Information

Community Health Nurse Educators And Disaster Nursing Education, Jody Spiess

Dissertations

Abstract

The world is struggling with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and the need for disaster nursing education has never been more clear. Recently, the American Nurses Association reported that of the over 32,000 nurses surveyed; only 11% felt well prepared to care for a COVID-19 patient (ANA, 2020). Community health nurse educators are tasked with educating future nurses on disasters, yet, little is known about this population’s perceived competence in disaster preparedness. The purpose of this study is to describe community health nurse educators' perceived competence in disaster preparedness.

The study is a descriptive, correlational …

Dna Aptamer-Drug Targeting Chemotherapy: Investigation Of Cell Cycle Inhibition Via S15 Aptamer – Norcantharidin Complex, Shannon Fehr

Senior Honors Theses

Lung Cancer is the leading cause of cancer related death in both men and women in the United States (Bray et al., 2018). Cancer treatments are often non-specific and kill many dividing cells within a patient causing unwanted side effects. Norcantharidin (NCTD) is a synthetic FDA approved treatment for cancers including non-small cell lung cancers (NSCLC). NCTD suppresses cell proliferation by inhibiting cells from exiting the G2 phase of the cell cycle. Aptamers are short single-stranded DNA or RNA molecules with ligand directed self-annealing capabilities allowing selective binding to specific targets. This paper will discuss the hypothesized effects of using …

The Long-Term Effects Of Japan’S Traumatic Experience In The Second World War And Its Implications For Peace In Northeast Asia, Eugen Koh, Tadashi Takeshima

New England Journal of Public Policy

This article is an introductory report on the work of a Japanese study group whose primary aim is peacemaking, which it seeks by promoting a greater understanding of the long-term effects of their country’s traumatic experience of the Second World War. The group does not adopt a position of victimhood but seeks to understand the full picture of Japan’s role in the war, including its role as perpetrator. We came together with the shared assumption that the country’s inability to take responsibility for its role of the war is inextricably tied to its own traumatization. If this assumption is true, …

Assessing Biobehavioral Effects Of Exposure To Traumatic Events In Palestinian Children, Mohammad Asia

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

Background: A growing body of work suggests that exposure of children to the trauma of war threatens their physical and psychological development. Children exposed to such childhood adversity have an increased risk of developing mental health problems, including posttraumatic stress disorder (PTSD), emotional and behavioral problems, and psychobiological ailments. Methods: This pilot study used a descriptive cross-sectional design to explore the relationships among traumatic event exposure, child stress, and biological stress markers (salivary cortisol and salivary alpha-amylase) measured in a sample of 37 West Bank Palestinian children aged 10-12 years. Results: Findings revealed moderate correlations between perceived child stress scores …

An Experimental Investigation Into Promoting Mental Health Service Use On Social Media: Effects Of Source And Comments, Zhaomeng Niu, Lun Hu, David C. Jeong, Jared Brickman, Jerod L. Stapleton

Health, Behavior & Society Faculty Publications

Mental health is an increasingly prevalent topic of public interest, but remains a complex area requiring focused research that must account for negative perceptions surrounding mental health issues. The current work explores the roles of social media information source credibility and valence of social media comments on health outcomes in such a mental health context. We used a 2 (message source: professional vs. layperson) × 3 (valence of comments: positive vs. negative vs. mixed) online experiment to examine the effects of source and valence of comments on trust, attitudes and intentions related to mental health information and services among 422 …

The Ideological Scalpel: Physician Perpetrators, Medicalized Killing And The Nazi Biocracy, Matthew D. Fuller

History in the Making

With the conclusion of the Nuremburg Doctor’s trials in August 1947, the role of German physicians in the concentration camps of Europe became a widely discussed and researched topic in the historiography of the Holocaust. Like many other perpetrators indicted by the Allies following the Second World War, German physicians claimed to have been swept up in the mass indoctrination of the National Socialist movement and had ultimately become powerless cogs within the Nazi totalitarian regime. While this claim may be true in some cases, the historiography of German physicians-turned-killers reveals different sources of motivation which allowed doctors in the …

2020 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Beth Heldebrandt

Programs

The 2020-2021 academic year is truly extraordinary and higher education’s new, hopefully temporary, normal began on rather short notice in Spring 2020. While our environment has changed, we, as a shared community, are pleased that the important work of faculty continues and evolves as faculty broaden and redefine the boundaries of scholarship, creativity, and innovation in accelerating hybrid and remote environments. And, as new forms and strategies for scholarship and creativity emerge, the core principles of faculty life and student learning remain central to the mission of Eastern Illinois University.

For that reason, our faculty, department chairs, college deans, the …

The Tuskegee Syphilis Experiment: The Implications Of Its Legacy, Joshua Barash, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Objectives

• Discuss details of the Tuskegee Study
• Summarize ethical issues
• Explore the legacy of Tuskegee: Distrust of the Medical Establishment

Imagining The Future Of Medicine Through A Lens Of Prejudice: Lessons From The American Past, Neil Nusbaum

Journal of Health Disparities Research and Practice

Many healthcare management decisions today, such as those about facility construction, will have impact even decades beyond the traditional 5 or 10 year planning horizon. In order to get some idea of the possibilities and challenges of today’s long range forecasts in healthcare, it is instructive to look at how well similar efforts fared a century ago. Looking in retrospect now, the task of prognostication then was impeded in part by a failure of vision due to prejudicial attitudes of the era.

Survey Of Airflow Around A Heated Manikin As A Simulated Aeromedical Evacuation Patient On A Litter With Computational Fluid Dynamics Models, George P. Lemmer

Theses and Dissertations

Aeromedical Evacuations remain the predominant method used to transport patients from forward deployed areas of operations to secure locations with more robust medical infrastructure. Transportation of chemical warfare casualties and infectious patients require additional attention to prevent cross contamination. Specific airflow characteristics paired with environmental control system settings are a gap in scholarly literature. Based on the available literature computational fluid dynamics models were created to simulate the airflow around a patient represented by human geometry using commercially available software. In order to compare simulated and experimental results a heated manikin was placed in the MURPHEE aerosol exposure chamber and …

An Intersectional Mixed Methods Approach To Understand American Indian Men’S Health, Ka‘Imi Sinclair, Kelly L. Gonzales, Claire Woosley, Tish Rivera Cree, Celina M. Garza, Dedra Buchwald

OHSU-PSU School of Public Health Faculty Publications and Presentations

This study used a parallel, convergent, mixed-methods design with TribalCrit theory and intersectionality as analytical frameworks to identify how the identities of American Indian men intersect with broader structures and systems in shaping their eating and physical activity choices and behaviors, and in eliciting recommendations for a men’s lifestyle intervention. American Indian men were recruited in Minneapolis, Minnesota, and Portland, Oregon, between March and December 2017, and in Phoenix, Arizona, in December 2019 to participate in a survey and focus groups. The survey included questions on demographics and physical and cultural activities men engage in, perceived social support for lifestyle …