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Research Day 2026 Program, Western Michigan University Homer Stryker M.D. School Of Medicine

Research Day

No abstract provided.

Glioblastoma Multiforme: A Pathologic Breakdown Of One Of Neuro-Oncology's Greatest Challenges, Rosemary Westphal, Ms

Student Papers, Posters & Projects

Glioblastoma multiforme is the most common adult primary tumor with a grim median survival time of 14.6 months. It is characterized by rapid progression, diffuse infiltration, and rather poor clinical outcomes. The WHO classifies GBM as a grade 4 diffuse astrocytic tumor with distinctive histopathological features including high mitotic activity, marked cellular atypia, microvascular proliferation, and necrosis. Advances in molecular diagnostics have further classified GMB into IDH-wild type and IDH-mutant subtypes, with important therapeutic and prognostic implications. Key genetic alterations, such as EGFR amplification, PTEN loss, TP53 mutations, TERT promoter mutations, and MGMT methylations, have been identified as contributing to …

Predicting Ventilation From Single Breathing Phase Non-Contrast Ct Using Swin Transformers, Yi-Kuan Liu, Hsu-Ting Kuo, Alaa Melek, Richard Castillo, Yevgeniy Vinogradskiy, Lili Zhao, Girish Nair, Edward Castillo

Department of Radiation Oncology Faculty Papers

BACKGROUND: Pulmonary ventilation imaging enables functional avoidance radiotherapy treatment plans by quantifying regional lung function. However, current clinical standards, such as 99𝑚Tc-based single-photon emission computed tomography (SPECT), rely on radioactive tracers, which can introduce imaging deposition artifacts. CT ventilation imaging (CTVI) methods based on both physical models and deep learning approaches currently require multiple CT images as input, such as the inhale/exhale phases of a 4DCT. While the theoretical foundation of physics-based CTVI is built on multi-phase information, the feasibility of single-phase deep learning CTV models has not been determined.

PURPOSE: While deep learning methods have predicted SPECT ventilation from …

The Acute Effects Of Heat Exposure On Cognitive Function, René Barbier

Presentations - 2026

Passive heat exposure negatively impacts: •Executive function & response inhibition •Attention & processing speed •Workplace productivity

Older adults face heightened vulnerability to cognitive decline under heat stress (Schlader et al., 2015).

Who is most affected?

•Outdoor & industrial workers •Athletes training in summer heat •First responders (firefighters, EMTs) •Older adults with thermoregulatory decline

San Antonio context: persistent summers, growing population, occupational health implications.

Evaluation Of An Affordable Prosthetic Liner In Resource Limited Settings, Samerial Brown

Posters - 2026

The lower limb prosthesis is an important assistive technology for persons with limb amputations and differences. The interface (prosthetic liner) between the rigid prosthetic socket and the residual limb is often made of silicone, urethane or thermoplastic elastomer gel. This material provides cushioning and support as well as suspension for the transtibial (below knee) prosthetic leg. Unfortunately the cost of liners range from $3-$600. This cost precludes its use in resource limited settings such as Sri Lanka. As a result patients are fit with a foam liner which has less cushioning and suspension capabilities than a gel type liner. This …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Setting Research Priorities For The Use Of Digital Technology In The Self-Management Of Heart Health: The Results Of The James Lind Priority Setting Partnership, Lis Neubeck, Simon Nichols, Nicola Straiton, Louise J. Dunford, Amitava Banerjee, Susan Dawkes, Donna Fitzsimons, Maria Hayes, Alistair Lawson, Abigail A. Lyons, Mary Mcauley, Jill Mclaggan, Richard Mindham, Nicholas L. Mills, Rakesh Modi, Alice Pearsons, Amanda Pitkethly, Fiona E. Strachan, Coral L. Hanson

Research outputs 2022 to 2026

Aims: There are wide inequalities in access to cardiovascular care, and risk factors such as obesity, high blood pressure, and physical inactivity are often not well managed. We aim to identify the most important questions about how digital technologies can help people and their carers prevent cardiovascular disease and improve access to care. Methods and results: A priority setting partnership that aimed to generate a top 10 list of research priorities for the use of digital technology in the prevention and management of heart disease and heart conditions in the UK and Ireland, with equal input by people with lived …

An Evidence-Based Educational Intervention To Enhance Nurses' Knowledge Of Metabolic Syndrome In Residential Care Facilities, Marie Tanyi

Doctor of Nursing Practice Scholarly Projects

The project addresses a critical gap in nursing education by implementing a structured, evidencebased educational intervention led by an Advanced Practice Registered Nurse (APRN) to improve nurses’ knowledge of metabolic syndrome in residential care facilities. The purpose was to determine whether this intervention could significantly enhance nurses’ understanding and management of metabolic syndrome, a complex cluster of disorders present in adult populations. Nine nurses participated in targeted educational sessions focusing on definition, diagnosis, complications, and evidence-based prevention and management strategies. Each participant completed the Metabolic Syndrome Knowledge Scale (MSKS) questionnaire before and after the intervention to assess changes in knowledge. …

Global Trends In Bioterrorism And Biosecurity Research Publications (1997–2025): A Scopus Bibliometric Analysis, Festus Mulakoli, Samuel Gesaka, John Mbataru

School of Nursing & Midwifery, East Africa

Introduction: Bioterrorism and biosecurity preparedness are critical pillars of global public health protection and resilience of health systems worldwide. Although this field has grown over the past few decades, there remains limited clarity on how research efforts have evolved and where critical gaps persist, particularly regarding global collaboration and emerging biological threats. To address this, we conducted a bibliometric analysis to map publication trends, influential contributors, and collaboration networks in bioterrorism and biosecurity from 1997 to 2025. This study analyzed global research output, collaboration, and thematic evolution in bioterrorism and biosecurity and identified gaps relevant to preparedness and policy. …

Une Com Spring Research Bulletin May 2026, Une Com Research & Scholarship

Osteopathic Student Research Symposia

Bulletin including abstracts from the University of New England College of Osteopathic Medicine’s 2026 inaugural Spring Research Update and Lightning Talk event.

Advancing The Understanding Of Palliative Care In Singapore: Knowledge, Attitudes, Receptiveness, And The Moderating Role Of Media Information-Seeking Preferences, Su Lin Yeo, Angel Lee, Raymond Han Lip Ng, May O. Lwin, Yumin Lin

Research Collection Lee Kong Chian School Of Business

Introduction: Despite the growing demand for palliative care, this specialized medical care remains severely underutilized, with almost 50% of countries worldwide lacking access. Given that misperceptions and stigma continue to hinder progress in healthcare policy, this study aims to examine the relationships between palliative care knowledge, attitudes, and receptiveness to better understand how public health communication can enhance awareness and understanding of the topic in Singapore. Applying the adapted knowledge-attitude-practice (KAP) model, it further extends theory by examining the moderating role of media information-seeking between knowledge and receptiveness.Methods: Mixed-mode surveys involving 1,226 participants (926 online and 300 in-person respondents), representing …

Deep Learning-Based Automated Pneumonia Detection From Chest X-Rays: A Comparative Study Of Custom Cnn And Transfer Learning Architectures, Ahmed Sajim

Honors Theses

Pneumonia is a leading global cause of mortality, claiming approximately 2.5 million lives an-nually and placing exceptional diagnostic pressure on radiologists in resource-limited settings. Manual interpretation of chest X-ray (CXR) images is time-consuming, subject to inter-observer variability, and limited by radiologist availability. This thesis presents a systematic investiga-tion into deep learning-based automated pneumonia detection comparing five convolutional neural network (CNN) architectures: a custom-designed 2D CNN and four pretrained transfer learning models—ResNet, DenseNet, MobileNet, and VGG19.

A targeted data augmentation pipeline addresses the severe class imbalance in the Kag-gle Chest X-Ray Pneumonia dataset, expanding the Normal class from 1,583 to 9,495 …

Reducing Computed Tomography Delay In A High-Volume Emergency Department, Sarah Ouedraogo

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem:

Delays in computed tomography (CT) imaging contribute to prolonged emergency department (ED) length of stay and delayed clinical decision-making. At the project site, baseline data demonstrated an average ASAP CT order-to-scan time of approximately 116 minutes for non-critical ED patients, with CT readiness compliance rates of 0%. Gap analysis identified inconsistent patient preparation and fragmented communication between ED nursing and radiology as key contributors to avoidable delays. PICOT question: In non-emergent emergency department (ED) patients (P), how does the use of a CT readiness checklist by ED nurses (I), compared with no standardized readiness checklist (C), affect patient readiness …

Increased Backbone Rigidity Of Artificial Transcription Factors, Jasmine Glover, Emma Otey, Joanna K. Kwao, Nicholas Truex

Senior Theses

Programming DNA-binding proteins is an effective strategy for developing therapeutics that regulate gene expression. These proteins can directly bind to DNA to activate or repress transcription of specific genes. Zinc finger proteins are a class of DNA-binding proteins commonly found in eukaryotic organisms. Their DNA-binding function is derived from unique amino acid sequences within each domain that recognizes specific nucleotides, allowing each finger to selectively recognize three DNA base pairs. Adjoining of multiple domains in tandem allows recognition of a specific DNA sequence. Artificial transcription factors can be made of multiple zinc finger domains arranged in tandem and engineered to …

Music Listening While Studying And Academic Performance Among College Students With Attention Deficit And Hyperactivity Disorder, Raihan K. Khan, Md Towfiqul Alam, Madalynn Nofplot, Sojib Bin Zaman, Catherine L. Zaman

Faculty Scholarship

Evidence on whether music listening supports academic performance, particularly among students with attention deficit and hyperactivity disorder (ADHD), remains mixed. We explored associations between music listening while studying and academic performance (GPA: grade point average) among college students, and to evaluate whether the associations differed by ADHD status. We analyzed cross-sectional survey data from college students and conducted linear regression models with self-reported GPA as the dependent variable. Models were adjusted for sex, academic level, college affiliation, primary study location, weekly study hours, and preferred genre of music. A total of 541 students participated. Most of the students were at …

Exploring Adolescents’ Social, Cultural, And Health Experiences To Inform Culturally Responsive Interventions, Bria D. Singleton

Theses and Dissertations

This study examined adolescents’ perceptions of their social, cultural, and health-related experiences, assessing constructs related to identity formation, digital exposure, belonging, and safety among Generation Alpha. Using a mixed-methods design, data were collected from students aged 11 to 14 enrolled at a public middle school in South Carolina using a structured survey and qualitative group discussions. Survey findings indicated primarily positive perceptions of school safety and a sense of self-efficacy in caring for their mental health and well-being. However, qualitative findings disclosed the adolescents’ acute awareness of environmental threats, such as gun violence and school shootings, resulting in emotional dysregulation …

Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Wednesday, April 1, 2026, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on April 1, 2026.

Human Osteosarcoma Cell Line That Overexpresses Cd4/Ccr5 Or Cd4/Cxcr4 To Study Hiv-Host Interactions, Harry Baffour Awuah

Biotechnology Theses

Human immunodeficiency virus type 1 (HIV-1) entry into host cells occurs through interactions between the viral surface envelope glycoprotein (Env) and the host receptor CD4, and co-receptors CCR5 or CXCR4. However, understanding these interactions in membrane contexts remains limited due to low receptor and coreceptor densities in commonly used cell models. To address this, we developed cellular systems with elevated CD4 expression and either CCR5 or CXCR4. Human osteosarcoma cells (HOS), which lack endogenous surface expression of HIV receptor (CD4) and co-receptors (CCR5 or CXCR4), were engineered via lentiviral transduction to overexpress CD4 and either CCR5 or CXCR4. Cells were …

Ten Tips On How To Optimize Nutrition In Children With Chronic Kidney Disease Or On Dialysis., Nonnie Polderman, Vanessa Shaw, Caroline E. Anderson, An Desloovere, Louise Mcalister, Christina L. Nelms, Fabio Paglialonga, Pearl Pugh, Leila Qizalbash, Evelien Snauwaert, José Renken-Terhaerdt, Jetta Tuokkola, Larry A. Greenbaum, Rukshana Shroff

Manuscripts, Articles, Book Chapters and Other Papers

Optimal nutrition is central to growth and development in all children, and is particularly relevant in those with chronic illnesses. This document provides 10 practical, evidence-informed tips on the assessment and management of the nutritional prescription in children with chronic kidney disease (CKD) and those receiving dialysis. The 10 tips synthesize work of the Paediatric Renal Nutrition Taskforce, an international team of pediatric renal dietitians and pediatric nephrologists who develop clinical practice recommendations for the nutritional management of children with kidney diseases. We describe a comprehensive, three-dimensional nutritional assessment (anthropometry, dietary intake, biochemical markers) and regular monitoring tailored to age, …

Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic And Metabolic Reprogramming, Samuel D. Jordan, Shuhua Fu, Abigail Fulkerson, Donghua Hu, Sherwin Ng, David M. Zhang, Sneha Manikandan, Jeffrey Szymanski, Nan Hu, Yuqian Xie, Anish Bedi, James Tabor, Lauren Boggs-Bailey, Lori Strong, Stephanie Hicks, Lavanya Aryan, Nishanth Gabriel, Geoffrey D. Hugo, Kuo-Chan Weng, Nathaniel Huebsch, Julie K. Schwarz, Bo Zhang, Stacey L. Rentschler

2020-Current year OA Pubs

Stereotactic arrhythmia radiotherapy (STAR) is emerging as a highly effective treatment for ventricular tachycardia (VT). Growing evidence indicates that STAR favorably reprograms the electrical substrate by speeding conduction and/or prolonging repolarization via modulation of ion channel expression, although the mechanisms by which single-fraction radiation mediates durable changes in gene expression are incompletely understood. Here, we identify dynamic changes in the cardiomyocyte epigenome and transcriptome after irradiation (IR) in vivo and in vitro, including durably increased expression and chromatin accessibility of Scn5a (encodes the α subunit of the sodium channel, NaV1.5), demonstrating a role for epigenetic memory in conduction velocity (CV) …

Investigating Social Justice Implications Of Glyphosate Residues In Human Urine, Ananya Malhotra

Electronic Theses, Projects, and Dissertations

Background: Glyphosate, the nominal active ingredient in professional-grade Roundup weed and grass killer, is the most extensively used herbicide globally and in the United States (U.S. Environmental Protection Agency, 2020). An increasing level of concern has surfaced regarding its health consequences, particularly because of contamination of our food supplies. Recent research indicates distressing levels of detection of glyphosate in human blood and urine samples, revealing many instances of frequent human exposure (Conrad et al., 2017; Zhang et al., 2020).Most of the research about exposure is focused on agricultural workers or individuals living in close vicinity to agricultural lands.  Few …

Influence Of Gut Microbiota On Response To Immune Check Point Inhibitors In Masld Patients With Hcc: Unraveling The Connection, Mazen Elsheikh, Mohamad Ali Ibrahim, Sherry Fares, Megha Bhongade, Karim Adhem, Ximena I Ramirez-Morales, Ahmed O Kaseb, Joseph Petrosino, Manal M Hassan, Prasun K Jalal

Faculty, Staff and Students Publications

Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction-associated liver disease (MASLD), exhibit resistance to ICI therapy. Studies have revealed that the presence of specific gut bacteria, such as Akkermansia, Bifidobacterium, and Lachnoclostridium, is associated with improved outcomes with ICI-treated HCC patients. Conversely, the overgrowth of bacteria like Enterobacteriaceae is linked to resistance to therapy. This review investigates the role of gut microbiota in shaping immune checkpoint inhibitor responses in MASLD-related hepatocellular carcinoma, focusing on how dysbiosis may …

Cure Sound Project: Study In Silence?, Quezia Abrao, Deeya Bhadresa, Elisa Castro, Fiona Coulbourne, Carlos Flores, Lizzeth Holguin, Lazarus Maldonado, Jeremy Mares, Andrew Martini, Nicole Matthews, Katherine Montero, Mariana Reyes, Jacob Rodriguez, Julieta Ruiz, Eliana Sanchez, Gabriela Varela

Posters - 2026

Difference in sound levels in study areas across campus can affect students’ ability to work and learn efficiently 1.

According to the WHO, safe sound levels are measured to be around 70dB 2. Some study areas on campus experience sound levels exceeding the safe threshold. Unsafe sound levels are considered to be at or above 85dB 3. These unsafe and excessive noise levels negatively affect a student’s ability to concentrate and work efficiently which correlates to a decrease in class performance, attention deficits, and stress 4.

This study aims to get a base-line measurement of dB levels in common study …

The Benefits Of Glucagon-Like Peptide 1 Agonists In Adult Women With Polycystic Ovary Syndrome, Bethany A. Johnson

Nursing Capstones

Background: PCOS is the most common endocrinopathy in women of reproductive age, affecting 5-6 million women in the United States. Symptoms include hirsutism, acne, hormone imbalances, menstrual irregularity, obesity, infertility, hypertension, and hyperlipidemia. GLP-1s are being studied for their benefits in women with PCOS.

Purpose: To review the current evidence on the efficacy of GLP-1 receptor agonists in improving symptoms and complications of PCOS.

Methods: This scoping literature review used three databases, including CINAHL Ultimate, PubMed, and ClinicalKey. Inclusion criteria were women 18 and older diagnosed with PCOS and studies that evaluated any type of GLP-1 and their effect on …

Menstrual Cycle Hormonal Fluctuations And Non-Contact Acl Rupture Risk In Female Athletes: A Literature Review, Alexa K. Larson

Honors Thesis

Anterior cruciate ligament (ACL) injuries are among the most common and debilitating injuries in athletic populations, with female athletes experiencing significantly higher rates of non-contact ACL rupture compared to males, often while participating in the same sports. Hormonal fluctuations associated with the menstrual cycle have been proposed as a potential intrinsic risk factor influencing injury susceptibility. The purpose of this literature review was to examine current research investigating how menstrual cycle-related hormonal fluctuations may influence the risk of non-contact ACL rupture in female athletes. A comprehensive search of PubMed, SPORTDiscus, and CINAHL databases identified fourteen peer-reviewed studies that met the …

Detecting Cancer Genes Using Graph Neural Networks, Marvin Masabo Nkaka

Posters - 2026

• Cancer survival prediction is challenging due to the complexity of genomic data and limited samples especially for rarer cancer types. • To address this challenge, we developed an Artificial Neural Network (ANN) model for survival analysis using RNA-sequencing gene expression data from The Cancer Genome Atlas (TCGA). • Moreover, a key concept we investigate was how transfer learning enhanced our model’s performance especially for rarer cancer types difficult to perform accurate survival analysis due to their limited samples.

Evaluation Of Prosthetic And Orthotic Technologies Using Ai Technology, Iris Reyna, Samerial Brown, Gary Guerra, Ed Khu

Posters - 2026

Individuals with lower limb prosthetics have amputations and abnormal limb motions, which poses a high risk of injury when doing everyday activities. In this field, evaluation of individuals' prosthetics are done through biomechanical analysis and gait analysis. This analysis is used to study human movement and evaluate the mobility and quality of life of amputee patients as well as determining the modifications, positioning, and alignment needed to ensure stability with prosthetic and orthotic technologies (Kumar & Bhowmik, 2024). Trunk flexion has importance to the study because of its impact on lower limb kinetics, kinematics, the increase of ground reaction forces, …

Deep Learning Based Approaches For Low Cost Defense Detection, Adele J. Noel-Rickert

All NMU Master's Theses

Pulmonary fibrosis is a progressive interstitial lung disease characterized by the accumulation of fibrotic tissue within the lungs, leading to impaired respiratory function and reduced quality of life. Early detection is important for disease management; however, accurate diagnosis often relies on high-resolution computed tomography (CT), which may not be accessible in all clinical settings. Chest radiography provides a lower-cost and widely available imaging modality, but interpretation of chest X-rays for fibrotic disease can be challenging due to subtle radiographic patterns and overlapping anatomical structures. This thesis investigates the use of multimodal deep learning techniques to assist in pul- monary fibrosis …

Modeling Early Indicators For Success In An Associate Degree In Nursing Program, Joseph D. Moss

Educational Leadership & Workforce Development Theses & Dissertations

Persistent nursing workforce shortages across the United States have increased the importance of Associate Degree in Nursing (ADN) programs as primary entry points into the profession. Community colleges prepare a substantial portion of the nursing workforce; however, attrition within ADN programs limits the number of graduates entering practice. Understanding factors associated with academic performance and program completion is essential for strengthening nursing education pathways and supporting workforce development. The purpose of this quantitative study was to examine early academic and sociodemographic factors associated with successful completion of an ADN program at a suburban community college.

Guided by Becker’s Human Capital …

Reducing Humpty Dumpty Syndrome In Pediatric Inpatients, Jeanene Burns

Electronic Theses and Dissertations

The Doctor of Nursing Practice project examined pediatric inpatient falls. The healthcare agency involved in the project identified concerns regarding pediatric inpatient falls. Data were collected on pediatric inpatient falls that occurred on two nursing units at this agency based on the Generalized Risk Assessment for Pediatric Inpatient Falls and the Humpty Dumpty Falls Prevention Scale. Results from the project indicated marginal statistical significance, with approximately a 60% reduction in falls after the implementation of the Humpty Dumpty Falls Prevention Scale. A recommendation for future research is a comparison of the two pediatric fall risk assessment tools after the Humpty …