Digital Commons Network^™

Whole-Body Anatomical Mapping Of Infiltration In Melanoma Of Unknown Primary (Mup): The Role Of Perivascular, Lymphatic, And Neurovascular Conduits, Brianny Medina, Zoe Barrett, Luke J. Lunsford, Chenell S. Anagbo-Dowetin, Xandria L. Parker, Emily E. Rowland, Mohammad A. Afani, Rasheed Agboola, Joshua Owolabi

Research Day

Introduction: Melanoma of Unknown Primary (MUP) presents a significant clinical challenge in tracing metastatic trajectories. While hematogenous dissemination is the traditional model, this study investigates angiotropism and perineural invasion—mechanisms where neoplastic cells migrate along the external surfaces of anatomical structures. Our research suggests that melanoma acts as a "hitchhiker," utilizing the adventitia of blood vessels and the epineurium of nerves as a private highway system. This study aims to provide a high-resolution, whole-body map of infiltration, documenting how these "extravascular conduits" facilitate the colonization of major organ systems. Methods: A high-resolution post-mortem mapping was performed on a 50-year-old male decedent …

Development And Pilot Implementation Of A Generative Ai-Powered Virtual Learning Assistant (Vla) In First-Year Pharm.D. Courses, Vivek S. Dave, Ankit Rochani, Priyanka Bhatt

Fisher Showcase 2026

To develop and implement a generative AI-powered Virtual Learning Assistant (VLA) within foundational Pharm.D. pharmaceutics courses (Pharmaceutics I & II).

Ms-Gator: Multi-Scale Graph Attention With Topological Reasoning For Segmentation And Classification Of Prostate Cancer Based On Gleason Scores Using Histopathology Images, Sujata Patil, Mahadeva Swamy, Kavitha Sooda, Rajanikanth Vadigepalli, Khalid Nazim Abdul Sattar, Md Rafeeq

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Prostate cancer is one of the prevalent and potentially fatal malignancies, affecting men globally. Accurate segmentation and classification of prostate cancer in histopathology images remain challenging due to complex tissue architecture, staining variability, and high inter-observer differences in manual diagnosis. To address these challenges, this research proposes a Multi-Scale Graph Attention with Topological Reasoning (MS-GATOR) for segmentation and classification of prostate cancer based on Gleason Scores (GS). The MS-GATOR incorporates topological reasoning with hierarchical biological structures by constructing a graph-based representation among three spatial scales such as nuclei, glands, and tissues using Delaunay triangulation to capture both geometric and photometric …

A Backend Database Architecture For Persistent Epilepsy Classification Records, Attiksh A. Panda, Deep Desai, Artem Zabarov, Katrina D. Prantzalos, Satya S. Sahoo, Shuai Xu

Student Scholarship

Epilepsy affects over five million people globally each year, yet consistent clinical diagnosis remains a persistent challenge due to the lack of standardized classification workflows across medical institutions. The Four-Dimensional Epilepsy Classification (4D-EC) framework, developed by Lüders et al., provides a comprehensive structure for characterizing paroxysmal events across four dimensions: seizure semiology, epileptogenic zone, etiology, and comorbidities. Despite its clinical and educational value, no dedicated informatics platform existed to support its routine use until recently, limiting widespread adoption among clinicians and trainees. This project addresses that gap by implementing a full-stack web application that operationalizes the 4D-EC framework for clinical …

Housing System And Gender Effect On Carcass And Meat Quality Characteristics In Turkish Pekin Ducks, Hasan Önder, Uğur Şen, Mi̇ne Yilmaz, Si̇bel Bozkurt, Eli̇f Ci̇lavdaroğlu, Di̇lek Gökçek, Ahmet Uçar, Kadi̇r Erensoy, Burcu Kurnaz

Turkish Journal of Veterinary & Animal Sciences

Improving meat quality is one of the most important aims for scientists and breeders. This study aimed to evaluate the effects of housing system (indoor vs. free-range) and gender on carcass and meat quality traits in Pekin ducks. The animal material consisted of 20 male and 20 female birds in each housing system. Our results show cold carcass weights of 3174.10 ± 80.65 g and 2672.60 ± 59.63 g for male and female birds in the indoor housing system and 2821.10 ± 50.53 g and 2306.90 ± 43.32 g for male and female birds in the free-range housing system. The …

Effects Of Preslaughter Fasting On Ph And Bacterial Contamination In Akkaraman And Anatolian Merino Sheep, Sai̇m Boztepe, Özcan Şahi̇n, Talha Demi̇rci̇, Gi̇zem Coşkun, İbrahi̇m Ayteki̇n, İsmai̇l Keski̇n

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of the preslaughter fasting on pH and bacterial contamination in Akkaraman and Anatolian Merino sheep. Included in the study were 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that were fasted for 24 h prior to slaughter, and a further 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that continued to be fed until slaughter as a control group. The total mesophilic aerobic bacteria (TMAB) measured at 0 and 24 h in the fasting Akkaraman and Anatolian Merino sheep were 4.87/4.79 and 4.75/5.57 log CFU/g, respectively, and the corresponding Enterobacteriaceae …

Brain Delivery Of Antibody-Derived Biologicals For Alzheimer’S Disease: An Updated Narrative Review, Rachita K. Sumbria, Ruben J. Boado

Pharmacy Faculty Articles and Research

Antibodies directed against β-amyloid (Aβ) have been developed for the treatment of Alzheimer’s disease (AD). However, the in vivo central efficacy is reduced by the poor penetration of antibodies across the blood–brain barrier (BBB). In addition, these antibodies have been associated with adverse effects like amyloid-related imaging abnormalities. Thus, the development of new antibody-based therapies for AD with improved transport across the BBB may improve efficacy and reduce adverse effects. Antibodies targeting the BBB transferrin receptor (TfR) are able to cross the BBB through receptor-mediated transcytosis, producing a global distribution throughout the brain. Along the same line, bispecific antibodies directed …

A Study Of Artificial Intelligence (Ai) Use Among Entry-Level Occupational Therapy Doctoral Students, Gustavo Reinoso, Rachel Allen-Mchugh, Thomas Decker, Yolanda Griffiths, Stacey Huffman-Main, Leslie Jackson, Ashley Murray, Jamie Rognes, Christine Urish

The Open Journal of Occupational Therapy

Artificial intelligence (AI) is increasingly integrated into higher education, yet little research explores its use among entry-level occupational therapy doctoral (OTD) students. This study developed a scale to assess AI usage and perceptions, examining differences across academic years. Eighty OTD students from a mid-sized urban university completed a 44-item survey refined using a Delphi method with nine faculty experts. Exploratory factor analysis identified three subscales—Efficiency and Adaptability, Academic Integrity Concerns, and the Student-Professor Divide—accounting for 46.04% of the variance (Cronbach’s α = .72–.93). Multivariate analysis of variance revealed significant effects of academic year on subscale scores (Wilks’ Λ = .822, …

Ethically Integrating Ai In Occupational Therapy Education: Enhancing Learning And Practice For The Future, Amy Sadek, Sabrina Gowette

The Open Journal of Occupational Therapy

Artificial intelligence (AI) has been around since the 1950s and is gaining traction in higher education and among health care professions. In this era of technology, it is imperative we equip both educators and students to have tech centric skills to support learning, improve efficiency, and enhance skills. Faculty and students alike need to be able to understand the ethics behind using digital information, such as that from AI tools and sources. As educators and students become more reliant on technology, and specifically AI, it is imperative not to lose the human connection in education. Educators are an integral part …

Promoting Mental Wellness And A Calm Learning Environment In A 2nd Grade Classroom, Grace Tone

Capstone Projects

Promoting mental wellness and implementing cognitive behavioral strategies brings awareness to staff and students and helps to promote a calm learning environment. School-based occupational therapists support students to participate in school occupations that they may be struggling with and provide them with cognitive behavioral strategies to regulate their emotions. The ACOTE concentration area for this capstone included education to staff members on the impact of mental wellness on student participation in school occupations and education on the Calm Moment Cards program from Every Moment Counts. The second ACOTE concentration area for this capstone was program development for sustainability of the …

Res-Mnd: Motor Neuron Disease Detection Using Res4net–Convolutional Block Attention Module ​, Shuriya Balusamy, Rakesh Sivalingam, Shobana Rooben, Sony Helen

Turkish Journal of Medical Sciences

Background/aim: Motor neuron diseases (MNDs) are progressive neurological disorders that cause muscle weakness and wasting as a result of ongoing neurodegeneration. MNDs require comprehensive diagnostic approaches that integrate clinical symptoms, laboratory findings, and multimodal imaging data.

Materials and methods: In this study, a novel residual network for motor neuron disease detection (RES-MND) framework is proposed for detecting MNDs using multimodal imaging data. Initially, the input multimodal images, including MRI, CT, PET, and DTI, are preprocessed using adaptive dynamic histogram equalization and the total variation bilateral filter. The preprocessed multimodal images are processed through Res4Net-CBAM for feature extraction to enhance image …

Sun-Macerated Hypericum Perforatum Oleates In Fixed Oils: Analytical Characterization And Comparative Wound-Healing Activity, Ci̇han Çapar, Esra Akkol, Ayli̇n Yaba, Ayhan Parmaksiz, Engi̇n Sümer, Erdem Yeşi̇lada

Turkish Journal of Medical Sciences

Background/aim: Hypericum perforatum L. oleates prepared in fixed oils have long been used for wound management due to their anti-inflammatory, antibacterial, and tissue-regenerative properties. The bioactivity of these oleates is mainly attributed to hypericin, hyperforin, and pseudohypericin. This study aimed to comparatively evaluate the wound-healing potential of H. perforatum oleates prepared in different fixed oils, including Olea europaea L. (olive), Sesamum indicum L. (sesame), Helianthus annuus L. (sunflower), and Nigella sativa L. (black seed).Materials and methodsFixed oils were characterized by GC–MS, while oleuropein in olive oil and thymoquinone in black seed oil were quantified by HPLC, and sesamin and sesamol …

Serum Phosphoproteome Alterations Associated With Cardiac Troponin I Levels In Acute Myocardial Infarction ​, Merve Öztuğ, Meltem Aşicioğlu, Konca Altinkaynak, Evren Kilinç

Turkish Journal of Medical Sciences

Background/aim: Acute myocardial infarction (AMI) triggers systemic biochemical responses, including dynamic changes in the phosphorylation status of circulating proteins. However, the phosphoproteomic profile of serum in the context of AMI remains insufficiently characterized. This study aimed to investigate serum phosphoproteomic alterations associated with AMI and to explore potential correlations with markers of cardiac injury.

Materials and methods: A comparative phosphoproteomic analysis was performed on serum samples obtained from eight patients with AMI and pooled healthy control samples. High-abundance serum proteins were depleted, and phosphopeptides were enriched using TiO2 phosphopeptide enrichment kit. Samples were analyzed by liquid chromatography–tandem mass spectrometry using …

A Model For Creating Ai-Generated Simulations For Clinically Complex Scenarios, Makayla Morning, Parker Litchliter, Jennifer Dulaney, Linda Haddox

Central & West Texas and San Antonio GME Research Day 2026

No abstract provided.

Comprehensive Profiling Of Gut Microbiota In Postmenopausal Osteoporosis ​, Gülsemi̇n Ertürk Çeli̇k, Sedat Yildiz, Münevver Aksoy Bektaş, Yaprak Engi̇n-Üstün

Turkish Journal of Medical Sciences

Background/aim: Osteoporosis is a multifactorial skeletal disease that predominantly affects postmenopausal women and is characterized by reduced bone mass and an increased risk of fractures. Growing evidence suggests that the gut microbiota plays a pivotal role in bone metabolism through immunological, endocrine, and metabolic pathways, forming the basis of the so-called gut– bone axis. This study aimed to characterize gut microbiota composition in postmenopausal women with osteoporosis compared with healthy controls.

Materials and methods: Forty postmenopausal women aged 55–65 years were classified into osteoporosis (n = 20) and healthy control (n = 20) groups based on dual-energy X-ray absorptiometry T-scores. …

Familybloom: Examining Ecologies Of Collaboration In Family-Centered Health Tracking, Lucas M. Silva, Aehong Min, Evropi Stefanidi, Franceli L. Cibrian, Jesus A. Beltran, Cassie Zeiler, Sabrina E. B. Schuck, Kimberley D. Lakes, Gillian R. Hayes, Daniel A. Epstein

Engineering Faculty Articles and Research

Family health informatics tools can help support well-being with shared data tracking. Prior work typically focused on shared data review, but often in specific moments, like bedtime, or centered on caregiving of children or elderly members. To investigate how tracking can support mutual health collaboration between family members pervasively across daily contexts, we designed and deployed FamilyBloom, a glanceable smartwatch and home display system for mood and goal tracking. Twelve families with both neurotypical and ADHD members used FamilyBloom for three months on average. Our findings reveal how family-centered tracking created collaboration opportunities and tensions across multiple ecological systems: individual …

Exploring Perspectives Of Autistic Individuals And Caregivers On Autism Inclusive Services In Public Libraries, Ayva J. Rose

LSU Master's Theses

Public libraries are increasingly recognized as important community hubs designed to promote literacy, learning, language, family engagement, and inclusivity. Despite this, autistic individuals may experience language, literacy, sensory, and social differences that could impact their ability to participate in literacy-based programming in libraries. Librarians currently report a desire to provide services that not only include but meaningfully support autistic children in their families; however, little research has examined how key stakeholders within the autism community perceive autism-inclusive programming within libraries. This research seeks to explore these perspectives and identify (1) perceived barriers to attending children’s library programs, (2) accommodations and …

Adoptive Cell Therapies For Glioblastoma: A Quest For Cures From Within, Jia-Shiun Leu, Xin Ge, Charles Robin Yu, Guang Peng, Jiyong Liang

The Brown Foundation: Institute of Molecular Medicine

Glioblastomas (GBMs) are the most aggressive form of brain cancer recalcitrant to both current standard-of-care and immune checkpoint therapies that benefit other cancer patients. Adoptive cell therapies (ACT) using patients' own immune cells have long been explored as a treatment strategy, including the historically studied lymphokine-activated killer (LAK) cells, the evolving chimeric antigen receptor (CAR) directed immune cells, the newly emerging tumor-infiltrating T lymphocyte (TIL) therapies, and others. Preclinical and clinical studies have shown promise but also highlighted significant challenges. In this review, we summarize these findings, highlight recent developments, discuss current limitations, and emphasize how ACT may benefit from …

Ethical Decision-Making Frameworks In Ai-Driven Pharmaceutical Research & Development, Dhaval Dinesh Panchal, Osama Mohd Hash Ansari, Sudha Divya Madhuri Kallam

Harrisburg University Dissertations and Theses

Artificial intelligence is increasingly being utilized in pharmaceutical research and development to speed up drug discovery, enhance clinical trial design, and support regulatory decision-making. However, the increasingly rapid adoption of AI in the pharma industry has outpaced the development of consistent ethical governance, raising concerns related to data privacy, transparency, regulatory compliance, and stakeholder trust. This study explored the methods by which project managers could develop and utilize ethical decision-making frameworks to facilitate responsible AI implementation in pharmaceutical research and development. Guided by the Responsible Innovation framework, this research employed a mixed-methods design combining semi-structured interviews and quantitative surveys with …

Engineering Of Genetically Encoded Programmable Calcium Channel Inhibitory Binders, Xiaoxuan Liu, Sher Ali, Tien-Hung Lan, Decheng Wang, Brendan Mckee, Tatsuki Nonomura, Siyao Liu, Feng Zhao, Michael X Zhu, Yun Huang, Qing Deng, Guolin Ma, Yubin Zhou

Faculty, Staff and Student Publications

Store-operated Ca2+ release-activated Ca2+ (CRAC) channels, composed of STIM and ORAI, are essential for immune and developmental processes, and their dysregulation underlies channelopathies such as Stormorken syndrome. Here, we report the engineering of genetically encoded CRAC channel inhibitory binders (CRABs) derived from the ORAI C-terminal tail. Guided by deep mutational scanning, we optimize a membrane-anchored CRAB variant that potently inhibits Ca2+ influx and NFAT signaling, and rescues thrombocytopenia-like phenotypes in a zebrafish model of Stormorken syndrome. To enable tunable inhibition, we further design oligomeric, optogenetic (Opto-CRAB), and chemogenetic (Chemo-CRAB) variants, providing graded and real-time control of CRAC activity. Chemo-CRAB further …

Digital Touchpoints: Investigating Contact Page Accessibility And Visual Authenticity Within Medical Tourism Health Websites, Alicia Mason, Elizabeth Spencer, Kristen Livingston, Treyton Meyers, Sakshi Bhati, Himika Akram

Faculty Submissions

This study examines two critical digital touchpoints on medical tourism provider (MTP) websites: (1) the accessibility of contact pages which often function as entry points for inquiries, scheduling, and pre-travel coordination, and (2) the authenticity of visual imagery used to shape expectations about care environments, personnel, and technological capacity. A sample of 105 MTPs across all six World Health Organization regions were analyzed using quantitative web accessibility testing and qualitative visual analysis. Results indicate pervasive accessibility errors on contact-page touchpoints and extensive reliance on inauthentic imagery to depict patients, providers, and medical technologies. Together, these practices may distort user expectations …

Theoretical And Practical Foundations Of Healthcare System Digitalization, Sanjarbek Bekturdiev Sharifboyevich Phd, Muxlisa G‘Ulom Qizi G‘Ofurova

Technical science and innovation

The digital transformation of healthcare represents a key direction in improving the accessibility, quality, and efficiency of medical services. This study examines the main components of eHealth, including telemedicine, electronic health records, cloud technologies, and mobile applications, as well as the role of international organizations in promoting national digital health strategies. Particular attention is given to the current state of digital healthcare in the Republic of Uzbekistan, where significant progress has been made in developing infrastructure and implementing information systems, although challenges related to integration, standardization, and regulatory support remain. The work identifies the main trends in the development of …

Health Insurance Literacy Among College Students At The University Of South Carolina, Emma J. Smith, Lorie Donelle Phd, Rn, Fcan, Robin Dawson

Caroliniana Undergraduate Research Journal

Purpose: This study aims to investigate the health insurance literacy skills of graduate college students and undergraduate college students.

Methods: A cross-sectional research design incorporated a 20-item questionnaire to examine college students’ knowledge of common health insurance terms and definitions, as well as their perceived understanding of health insurance. Descriptive analyses were conducted of participant demographics, health insurance literacy scores were summarized, and common health insurance policies were tested through a readability checker.

Results: The majority of students were between the ages of 18-25 and undergraduate students. More than half of the participants were female, and more …

The Next Gold Rush May Be In The Stars, Ned Markham

Osmosis Magazine

No abstract provided.

How Do Vaccines Work?, Natalie Small

Osmosis Magazine

No abstract provided.

Relaxin: Could This Pregnancy Hormone Be A Cure-All?, Eloen Beebee

Osmosis Magazine

No abstract provided.

Is Artifical Intelligence "Truly" Intelligent?, Camila Nicole Valdman

Osmosis Magazine

No abstract provided.

Improving Functional Electrical Stimulation Prescription For Persons With Multiple Sclerosis: A Case Series, Kurt Jackson

Thomas C. Hunt Building a Research Community Day

Purpose: Despite a growing body of evidence supporting the use of functional electrical stimulation (FES) in persons with MS (PwMS), prescription remains a highly individualized process with no well-established guidelines for assessing the immediate or long-term effects to ensure maximum benefit.  The purpose of this case series was to assess the feasibility and benefits of using wearable sensors and video analysis to provide immediate feedback on gait performance, when using lower leg and thigh stimulation individually or in combination, to improve FES prescription.

Subjects: 3 adults with multiple sclerosis (MS) with varying levels of gait dysfunction.

Methods: During …

Risk Factors Affecting Functional Outcomes Of Traumatic Brain Injury Patients During Long-Term Acute Care Hospital Rehabilitation, Arturo Olazabal

Walden Dissertations and Doctoral Studies

Traumatic brain injury (TBI) is a major public health concern associated with long-term disability and high healthcare utilization. Evidence guiding post-acute rehabilitation for medically complex TBI populations remains limited, particularly in long-term acute care hospital (LTACH) settings serving medically unstable patients. This study examined clinical and system-level factors associated with functional rehabilitation outcomes among adults with moderate-to-severe TBI in LTACHs. Guided by the Socioecological Model, recovery was conceptualized as interactions across individual, clinical, and organizational levels. This dissertation included three manuscripts using cross-sectional logistic regression and CMS Section GG measures. In Manuscript 1, longer time from injury to LTACH admission …

Reducing Inter-Rater Discrepancies During Administration Of The Canadian Occupational Performance Measure (Copm) Within An Interdisciplinary Research Team, Julia E. Moore

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Background: Consistent administration of outcome measures is essential for producing reliable research data, particularly in stroke rehabilitation where client-centered goals guide intervention (Kelly-Hayes, 2004). The Canadian Occupational Performance Measure (COPM) is widely used to evaluate self-identified occupational performance goals; however, variability in administration among research team members may introduce inter-rater discrepancies and bias in data collection (COPM) (n.d.). Within the Medical University of South Carolina Stroke Recovery Research Center, inconsistent COPM administration was identified during analysis of data and informal interviewing from an ongoing study. Informal interviews were conducted with 7 occupational therapists experienced in neurorehabilitation to identify barriers to …