Digital Commons Network^™

Reply, Jacqueline L. Chen, Amanda J. Lu, Rohan Verma, Li Wang, Douglas D. Koch, Allison J. Chen

Department of Medicine Faculty Papers

No abstract provided.

Preparing For The Next Big Thing: We’Ve Seen What Ai Can Do. Now, Get Ready For Cloning., Stuart L. Segelnick Dds, Ms

The New York State Dental Journal

Until recently, artificial intelligence was seen as science fiction. Now, it is interwoven into all aspects of our lives, including our dental practice. Cloning may be the next futuristic fantasy to permeate our consciousness. According to Leslie G. Biesecker, M.D., director and NIH Distinguished Investigator, Center for Precision Health Research, “Cloning, as it relates to genetics and genomics, involves using scientific methods to make identical, or virtually identical, copies of an organism, cell or DNA sequence.” As the cloning process and other bioengineering techniques advance, one can only wonder how and when they will impact the dental landscape.

J Mich Dent Assoc Sept. 2026

The Journal of the Michigan Dental Association

Each month, the Journal of the Michigan Dental Association delivers news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200-plus members. It remains the main publication reaching Michigan dentists and is available worldwide through ADA Commons.

The September 2026 (Volume 108, No. 9) issue of the Journal is published in print format to provide updates and insights for Michigan's oral health community and MDA members. Print editions occur every other month beginning with January.

This full compilation of the September 2026 Journal of the Michigan Dental Association features the deans' reports from the …

Diffusion-Informed Joint Segmentation Enhances Detection Of Thalamic Atrophy In Parkinson’S Disease, Gozde Kizilates-Evin, Ani Kicik, Emel Erdogdu, Dilek Betul Saridede, Sevim Cengiz, Basar Bilgic, Hasmet A. Hanagasi, Esin Ozturk-Isik, Tamer Demiralp, Ali Bayram

All Works

The thalamus is a critical subcortical hub that relays sensorimotor information and regulates higher-order cognitive processes. Accurate delineation of thalamic nuclei is essential for elucidating disease mechanisms and tracking clinical progression. In this study, we compared two segmentation approaches implemented in FreeSurfer: the conventional structural method and a joint framework that integrates diffusion tensor imaging. Magnetic resonance imaging (MRI) data from 24 healthy controls (HC), 27 patients with cognitively normal Parkinson’s disease (PD-CN), and 33 Parkinson's disease patients with mild cognitive impairment (PD-MCI) were analyzed. Segmentation methods were compared in HC to assess their effect on volume estimates. Group comparisons …

The Rise And Fall Of Lateral Electrical Surface Stimulation (Less) Through The Lens Of Srs Archives., Ali Rezazadeh Shirazi, Jay I. Kumar, Katie Dold, George H. Thompson, Andrew G. King, Richard M. Schwend, John P. Lubicky, Jay Shapiro, Behrooz A. Akbarnia, History Committee Of The Scoliosis Research Society

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Lateral electrical surface stimulation (LESS), commercially known as the ScoliTron™, emerged in the late 1970s as a noninvasive alternative to bracing for adolescent idiopathic scoliosis. Early clinical reports generated considerable enthusiasm and adoption, but the technique was ultimately abandoned. This study examined the rise and fall of LESS through a combined analysis of the Scoliosis Research Society (SRS) archives and published literature, with the goal of understanding factors that influence the adoption, evaluation, and abandonment of innovation in scoliosis care.

METHODS: A structured historical review was conducted using archival materials from the Scoliosis Research Society (SRS), including meeting abstracts, …

Patient-Specific Computational Fluid Dynamics Modeling Of Airway Collapse In Infants With Robin Sequence., Gautam Jalori, Michael Barbour, Michael Bindschadler, Kelly Evans, John P. Dahl, Alberto Aliseda

Manuscripts, Articles, Book Chapters and Other Papers

Robin Sequence (RS) is a congenital condition in which patients experience dynamic, periodic obstruction or collapse of the upper airway due to an underdeveloped jaw and a posteriorly displaced tongue. Current clinical techniques for evaluating airway obstruction do not provide quantifiable data and fail to account for the dynamic nature of obstruction or collapse. There is no standardized criterion to characterize obstruction or collapse severity. This study presents the first method that extracts airway motion from 4-dimensional computed tomography and performs a patient-specific, moving-mesh computational fluid dynamics (CFD) analysis of RS patients with complete airway collapse or obstruction. To quantify …

Towards Human-Centered Digital Health Interventions, Kristin M Kostick-Quenet, Eric A Storch

Center for Medical Ethics and Health Policy Staff Publications

This article discusses the potential of digital health interventions (DHIs) in mental health care, emphasizing the importance of designing them to foster genuine humanistic care. It highlights current challenges in measuring engagement and outcomes, advocating for integrating human-centered endpoints such as dignity, autonomy, and therapeutic alliance into evaluation frameworks. The authors call for mechanistic research to identify effective engagement strategies and context-specific implementation approaches. Ultimately, successful DHIs should demonstrate both clinical efficacy and the preservation of humane, person-centered care, ensuring ethical and meaningful mental health support through technology.

Spinal Cord Imaging For Multiple Sclerosis: Advances, Priorities, And Opportunities, Cornelia Laule, Matthew R Brier, Et Al.

2020-Current year OA Pubs

The spinal cord plays a central role in the pathophysiology and clinical manifestations of multiple sclerosis (MS), yet remains under-studied compared with the brain. This review summarizes key insights from the 2025 North American Imaging in MS Spinal Cord Imaging Workshop, highlighting recent advances, ongoing challenges, and future opportunities in MS spinal cord imaging. We review pathological studies and outline the clinical relevance of spinal cord lesions and atrophy for diagnosis, prognosis, and disease monitoring, highlighting emerging biomarkers of progression independent of relapse activity. Correlations between magnetic resonance imaging, histopathology, and clinical outcomes support the validation and translational potential of …

The Mathematical Model Predicts Peripheral Blood Cd34+ Cell Yield And Blood Volume Processing For Peripheral Blood Stem Cell Apheresis., Rattaporn Vichitratchaneekorn, Kanokpol Siriphanthong, Kanokwan Chinbordee, Phandee Watanaboonyongcharoen, Ponlapat Ronjnuckarin

Chulalongkorn Medical Journal

Introduction: The accurate prediction of stem cell yields is important for planning peripheral blood stem cell (PBSC) collection. This study aimed to develop a formula forecasting required blood volume processing to ensure adequate CD34+ cell products.

Methods: Data from donors and patients who underwent PBSC apheresis conducted at a tertiary care hospital were reviewed. BD FACSCanto™ II and Navios EX flow cytometry machines were used to determine the pre-collection CD34+ cell counts (preCD34).

Results: Of 50 donors and 85 patients, 145 leukapheresis procedures were performed. Linear regression models accurately predicted absolute CD34+ cell yields from pre-apheresis values, supporting optimal procedural …

Assessing The Reliability Of Machine Learning Models In Classifying Depression Severity Using Facebook Text, Keito Yoneyama

Chulalongkorn Medical Journal

Depression is a growing global issue that requires urgent attention, particularly in Thailand. Without timely intervention, it can lead to serious consequences such as health complications, reduced social participation, and even suicide. Consequently, there has been increased research focused on developing algorithms to identify and classify social media data according to depression severity. This study aimed to evaluate the extent to which such algorithms are a suitable tool for the preliminary classification of Thai Facebook text into different levels of depression severity. The methodology involved data collection through surveys and Facebook scraping, followed by data preprocessing, feature engineering, and model …

A Causal Association Between Alkaline Phosphatase And Natural-Cause Mortality: A Mendelian Randomization Study In East Asians And Europeans., Hung-Lin Chen, Ping-Hsun Wu, Yi-Ting Lin, Amrita Chattopadhyay, Hsiu-Yin Chiang, Yu-Ting Lin, Ya-Chi Lin, Che-Chen Lin, Min-Yu Chiang, Hung-Chieh Yeh, I-Wen Ting, Yu-Cyuan Hong, David Ray Chang, Jenq-Wen Huang, Yu-Ting Lin, Wei-Chi Syu, Tzu-Pin Lu, Yi-Chun Tsai, Fuu-Jen Tsai, Chin-Chi Kuo

BioMedicine

Background: Although observational studies show a positive association between alkaline phosphatase (ALP) levels and mortality, a causal study is not yet available.

Objective: We conducted a retrospective cohort study and a systematic one-sample Mendelian randomization (MR) study to investigate the causality of ALP on natural-cause mortality.

Methods: The study used a hospital-based cohort of Asian patients recruited from the China Medical University Hospital (CMUH) and a community-based cohort of white European participants from the UK Biobank (UKB). Two retrospective cohorts included 43,994 patients from CMUH and 80,941 participants from UKB, all aged 50–55 years, with ALP measurements. For the MR …

Development Of Ultrafast Protein Digestion And Standards Free Quantitation Methods For Mass Spectrometric Analysis, Praneeth Ivan Joel Fnu

Dissertations

A wide variety of biologically important molecules, such as enzymes, antibodies, hormones, transporters and receptors are proteins by composition and they play key roles in biological functions such as cellular regulation, communication, metabolism and physiological function. Protein dysfunctions and abnormalities are associated with numerous diseases, making proteins critical targets for understanding disease mechanisms and developing therapeutic interventions. Protein-based therapeutics such as monoclonal antibodies, hormones and vaccines gained popularity due to their high specificity, efficacy, and ability to treat complex diseases that are often difficult to address with small-molecule drugs.

Given the important role of proteins in a variety of biological …

Beyond The Binary: Strengthening Nursing Students’ Proficiency Of Equitable Health Promotion, Martha K. Findley

Theses

Background: Sexual and gender diverse (SGD) populations continue to experience significant health inequities, yet prelicensure nursing curricula often lack structured, evidence‑based training to prepare students for equitable care.

Purpose: This study evaluated whether a targeted, transgender‑focused simulation could improve nursing students’ clinical knowledge and preparedness for providing equitable health promotion to SGD populations.

Methods: A pre‑/post‑intervention design was used with senior‑level nursing students who completed a transgender patient simulation emphasizing communication, assessment, and equitable health promotion. Students completed a validated survey measuring knowledge and preparedness in caring for SGD patients.

Results: Significant improvements across most survey items demonstrated that the …

Implementing A Routine Fall Risk Assessment In Older Adults In An Inpatient Psychiatric Setting, Amaka Obi

Walden Dissertations and Doctoral Studies

The purpose of the project was to implement and evaluate a structured fall risk assessment process that promoted the early identification of patients at increased risk for falls and supported interventions designed to prevent fall-related events. A pre- and post-implementation evaluation design was used to assess the intervention's effectiveness by comparing fall rates before and after implementation of the standardized assessment protocol. De-identified data obtained from the electronic health record (EHR) were analyzed using descriptive statistics to evaluate changes in fall incidence and protocol adherence. The project findings demonstrated that provider-led, standardized fall-risk assessments improved screening compliance, provider adherence, and …

Isolation, Structural Characterization, And In Vitro Bioactivity Assessment Of Extracellular Vesicles Derived From Lacticaseibacillus Paracasei, Dwi Liza Ramadiani, Ratika Rahmasari, Tri Wahyuni, Kusmiati Kusmiati, Herman Irawan, Khatarina Meldawati Pasaribu

Pharmaceutical Sciences and Research

The field of study on extracellular vesicles (EVs) has recently focused on probiotic bacteria, due to their ability to exhibit a wide variety of biological activity. Therefore, this study aims to evaluate the effect of nutrient modulation during Lacticaseibacillus paracasei cultivation on EVs production and bioactivity. EVs were isolated by ultrafiltration method and were characterized using NTA and cryo-TEM. An in vitro evaluation was used to assess the bioactivities, antioxidant properties, anti-inflammatory potential, and ability to inhibit α-glucosidase activity. The results showed that the 2 LPEV exhibited the characteristics of vesicles with size of 96.04–100.29 nm. Cultivation in 50% MRS …

Flaxseed Ethanolic Extract Modulates Β-Catenin And Dkk1 Expressions During Osteoblast Differentiation Of Dental Pulp-Derived Stem Cells, Nur Sazwi Nordin, Khairani Idah Mokhtar, Omar Abdul Jabbar Abdul Qader, Basma Ezzat Mustafa, Widya Lestari, Deny Susanti Darnis, Thirumulu Ponnuraj Kannan, Azlina Ahmad, Solachuddin Jauhari Arief Ichwan

Journal of Dentistry Indonesia

Background: WNT signaling regulates osteogenic differentiation of mesenchymal stem cells (MSC) through the canonical WNT pathway. β-catenin; an important molecule of WNT pathway, and DKK1; a WNT antagonist, play important roles in regulating bone formation. Although flaxseed (Linum usitatissimum) has various health benefits, including promoting bone health, our previous study showed that flaxseed ethanolic extract (FEE) reduced the osteoblast differentiation potential of stem cells from human exfoliated deciduous teeth (SHED). This study aimed to determine the effects of FEE on WNT pathway-related molecules, β-catenin and DKK1, during osteoblast differentiation of SHED.

Methods: RNA at Day 7, 14, …

Analysis Of Pharmacotherapy And Non-Pharmacotherapy Burden From The Ina-Cbgs Package For Cesarean Section Surgery At The Regional General Hospital Dr. Soedarso In 2023, Ananda Rizky Awwaliyah, Nurmainah Nurmainah, Ridha Ulfah

Pharmacology and Clinical Pharmacy Research

The prevalence of cesarean sections has been increasing each year. Previous studies show that the cost of medications and medical supplies for cesarean patients accounts for one-third of the total care costs. In the era of National Health Insurance (NHI), medications and medical supplies are considered operational expenses for hospitals rather than sources of income. This condition requires proper medication management and the use of medical supplies. This study aims to analyze the percentage of pharmacotherapy and non-pharmacotherapy, including the types and quantities of medications as well as disposable medical supplies used on patients undergoing cesarean section procedures at the …

Environmental Perspective For System Dynamics Modeling Of Stunting Mitigation To Achieve The Sustainable Development Goals In West Sumatra, Indonesia, Elsa Yuniarti, Nabila Azzahra, Yulhendri Yulhendri, Heldi Heldi, Mery Delvina, Saskia Putri Azeli

Kesmas

This study developed a system dynamics model to simulate stunting reduction in West Sumatra Province, Indonesia, by integrating infant and toddler health, maternal health, and environmental determinants. Secondary data from 2020–2024 on low birth weight, immunization, malnutrition, exclusive breastfeeding, maternal chronic energy deficiency, iron and folic acid supplement distribution, sanitation, and safe drinking water access were compiled from West Sumatra Provincial Health Office and Statistics Indonesia, and validated through consultation with five stakeholder institutions. Causal Loop Diagrams mapped feedback relationships among determinants and were translated into Stock Flow Diagrams using Powersim Studio 10. The model was validated through structural verification, …

Regional Plantar Pressure In The Transmetatarsal Amputation Limb Under Different Contralateral Limb Conditions: An Exploratory Case-Comparison, Hafizur Rahman, Sidketa Fofana, Gerrard Farrell, Luis Venegas, Javier La Fontaine

School of Podiatric Medicine Publications

Background: Transmetatarsal amputation (TMA) alters foot biomechanics and is associated with abnormal plantar loading that may contribute to plantar tissue breakdown. Although plantar pressure abnormalities following TMA have been reported, the potential role of contralateral limb status in regional plantar loading patterns remains incompletely understood. This exploratory case-comparison study examined plantar loading under two different contralateral limb conditions. Methods: This exploratory case-comparison evaluated in-shoe plantar pressure in two individuals with unilateral TMA: one with an intact contralateral limb and one with a contralateral transtibial prosthesis. Plantar pressure data were collected using a Pedar-X system during overground walking at a self-selected …

Reactive Oxygen Species In Cardiovascular And Hematological Diseases: Mechanisms And Therapeutic Strategies, Anthony L. Alanis, Fernando Cisneros, Hector Trejo, Angela Hong, Kelsey Baker, Alex Zuo

School of Medicine Publications

Reactive oxygen species (ROS) play a vital role in normal cellular functions, including cellular signaling and metabolism of toxins. Excessive ROS contributes to the pathogenesis of cardiovascular and hematologic conditions by altering genetic expression, signal transduction, lipid peroxidation, and vascular remodeling. This article investigates the role of ROS in diseases such as cardiovascular disorders and hematological conditions, focusing on molecular mechanisms and emerging treatments for preventative and acute management. We analyzed the role of ROS in mitochondrial dysfunction, redox signaling pathways, and their contribution to inflammation and tissue damage across cardiovascular and blood disorders. We also discuss novel therapies targeting …

Biallelic Variants In Kmo Cause A Novel Form Of Congenital Nad Deficiency, Nathalie M Aceves-Ewing, Nanbing Li-Villarreal, Xiaohui Li, Seema R Lalani, Jill A Rosenfeld, Varduhi Petrosyan, Aleksandar Milosavljevic, Angelina Gaspero, Denise G Lanza, Audrey E Christiansen, Amrit Koirala, Abu Hena Mostafa Kamal, Nagireddy Putluri, Cristian Coarfa, Bao Tran, Philip L Lorenzi, Lin Tan, Charul Gijavanekar, Sarah H Elsea, Emily Lawrence, Hartmut Cuny, Sally L Dunwoodie, Pengfei Liu, Haonan Zhouyao, Tara L Rasmussen, Mary E Dickinson, Carlos A Bacino, Brendan Lee, Ronit Marom, Undiagnosed Diseases Network, Bcm Center For Precision Medicine Models, Jason D Heaney, Chih-Wei Hsu, Lindsay C Burrage

Faculty, Staff and Students Publications

Congenital NAD deficiency disorder (CNDD) is a gene × environment disorder caused by disruptions of the kynurenine pathway. To date, CNDD has been associated with biallelic variants in three kynurenine pathway genes: KYNU, HAAO, and NADSYN1 . We identified two sisters with congenital anomalies overlapping with CNDD who have biallelic variants in a gene encoding a different kynurenine pathway enzyme, KMO . The surviving child also has elevated levels of metabolites upstream of KMO with low NAD + levels in plasma, suggesting that KMO deficiency is a novel CNDD. To explore the pathogenicity of KMO deficiency, we generated a global …

An Annotated Walkthrough Of Dental And Dental Hygiene Professional Oaths

Journal IDA

Most of the information contained in this article was taken using AI search engines. It is meant to be a refresher for dentists and dental hygienists as it relates to the oaths we took when we graduated from our training programs. It is also meant to be an opportunity for practitioners to reflect on their journeys since graduation as to have true they stayed to the oaths that they took. Dental assistants are not required to take a professional oath in Indiana.

Ethical Considerations In Cosmetic Dentistry

Journal IDA

Dentistry is both an art and a science. Patient care revolves around treatment for pain, missing teeth while also ensuring that appearances or the esthetic outcomes are maintained or enhanced. These two facets are not contradictory, but are intertwined for optimal, complete and customizable care for each patient. Dentists are often faced with requests from patients for a stereotypical “perfect” smile, which includes perfectly aligned teeth that are white in color resembling the image commonly conveyed by the media. As clinicians, we respond in our own way to these increasingly demanding esthetic demands. Some specialize in developing “esthetic” treatments; others …

Recent Advances In Periodontology

Journal IDA

Periodontology is a dynamic discipline focused on the prevention, diagnosis, and treatment of diseases affecting the supporting structures of the teeth and dental implants. Given the complex and multifactorial pathogenesis of periodontal and peri-implant diseases, the field continually evolves to address diverse clinical needs through evidence-based innovations. Recent years have witnessed significant advances in biomaterials, biologics, diagnostic tools, and minimally invasive therapies that have transformed the clinical management of periodontal conditions. These developments aim not only to improve treatment efficacy and patient outcomes but also to expand the scope of regenerative and patient-centered care. The purpose of this paper is …

Journal Ida 2025 104 2

Journal IDA

In the Spring 2025 issue, the reader will find the following feature articles:

• Teaching the Next Generation: Challenging the Narrative and Shifting Perspectives
• Recent Advances in Periodontolgy
• Role of Microsurgery in the Evolution of Periodontal Surgery
• Diagnostic ChallengeL Oral Pathology
• Factor V Lieden Heterozygosity and Hypertriglyceridemia in 88 Patients with Chronic Jaw Pain and Alveolar Osteonecrosis
• Guided Tissue Regeneration of Localized Deep Combined 3-to-3 Wall Angular Defects: A Clinical Case Report with 15-Month Follow-up

This issue also includes regular columns from the editor, the executive director as well as membership news.

Journal Ida 2025 104 3

Journal IDA

In the Summer 2025 issue, the reader will find the following feature articles:

• Dental Sticky Situations
• Defining Prescriptive Supervision and Delegation in Indiana: The Essential Roles of the Dental Hygienist and the Dental Assistant on the Dental Team
• Safeguarding Ethics: The Work of the Indiana State Board of Dentistry
• Dental Treatment: Who Has the Final Say on Oral Health Care?
• Overview of Indiana Health Records Law
• Ethical Considerations in Cosmetic Dentistry
• Protecting Dentistry’s Ethics: IDA’s Peer Review Program
• An Annotated Walkthrough of Dental and Dental Hygiene Professional Oaths Using AI Search Engines
• Radiation Safety in Dental Offices: Where Do We …

Journal Ida 2025 104 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2023 102 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2022 101 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2021 100 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.