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Full-Text Articles in Entire DC Network
From Shortage To Strategy: Optimizing Scarce Resource Allocation In Healthcare, Daniela Duran Cantarino
From Shortage To Strategy: Optimizing Scarce Resource Allocation In Healthcare, Daniela Duran Cantarino
USF Tampa Graduate Theses and Dissertations
The allocation of scarce medical resources presents one of the most consequential challenges in health care, requiring decisions that balance equity and efficiency under pervasive uncertainty. This dissertation develops optimization-based frameworks for two critical domains, organ transplantation and emergency medical services, and demonstrates how operations research methods can improve upon current practice along both dimensions simultaneously.
In the domain of deceased-donor kidney allocation, two complementary frameworks are proposed. The first is a bi-objective stochastic optimization model that jointly maximizes post-transplant survival (efficiency) and prioritizes candidates with the highest pre-transplant mortality risk (equity), subject to regional chance constraints on graft failure …
Primary Care Reimbursement: Current Processes And Future Advocacy, Brenda Koverman, Monika I. Robinson, Lydia Royeen
Primary Care Reimbursement: Current Processes And Future Advocacy, Brenda Koverman, Monika I. Robinson, Lydia Royeen
The Open Journal of Occupational Therapy
Occupational therapy’s (OT) role in primary care is emerging as a viable practice area. Yet, operational efforts that include reimbursement continue to lag and have been identified as a barrier to entry. Current literature reveals confusing and overlapping reimbursement descriptions. Payment for services is critical for the sustainability of this practice area. This paper proposes a taxonomy to assist frontline clinicians, leaders, and provider practice managers to determine the best reimbursement strategy for their specific clinic. Differentiating and defining payment models, reimbursement determinants, and reimbursements methods allows OT leaders a shared language. Implementing the best reimbursement tactic will ensure the …
Comparative Evaluation Of Radioisotope Accumulation In Stems And Leaves Of Wild Flora In Nineveh Governorate For Environmental Pollution Indicator, Amina Q. Al-Bakri, Ayman Albanna, Mazin N. Fadhel
Comparative Evaluation Of Radioisotope Accumulation In Stems And Leaves Of Wild Flora In Nineveh Governorate For Environmental Pollution Indicator, Amina Q. Al-Bakri, Ayman Albanna, Mazin N. Fadhel
BioMed Visions Journal
It is a comparative assessment of natural deposition of radioisotopes in wild plants' stems and leaves from 11 sites of Nineveh Governorate, Iraq. Levels of ^226Ra, ^232Th, and ^40K activities were determined using high-resolution gamma spectrometry, and radiological equivalent indices—Radium Equivalent Activity (Raeq), Absorbed Dose Rate (D), Annual Effective Dose Equivalent (AEDE), Annual Gonadal Dose Equivalent (AGDE), Excess Lifetime Cancer Risk (ELCR), and hazard indices (Hex, Hin, Iγ) were determined. All results indicated invariably greater radionuclide accumulation in leaves than in stems at every station. Mean Raeq in leaves was 63,473 Bq/kg and in stems 60,854 Bq/kg, and the highest …
Ethical, Regulatory, And Equity Challenges Of Ai In Pharmaceutical Advertising, Samer Imad Mohammed, Fadia Thamir Ahmed
Ethical, Regulatory, And Equity Challenges Of Ai In Pharmaceutical Advertising, Samer Imad Mohammed, Fadia Thamir Ahmed
BioMed Visions Journal
Background: Artificial intelligence (AI) and chatbots are significantly altering pharmaceutical advertising by facilitating personalized patient engagement and enhancing treatment optimization. Their adoption presents substantial ethical, regulatory, and equity challenges that require thorough analysis. Objectives: The objectives of this review are to analyze: (1) the implementation of AI technologies, such as chatbots and predictive analytics, in pharmaceutical advertising; (2) ethical risks, including algorithmic bias and misinformation; (3) deficiencies in global regulatory frameworks, specifically those of the FDA and EMA; and (4) effects on health equity, with a focus on vulnerable populations. Methods: A narrative review was conducted using several databases with …
Grated Green Apple And Its Therapeutic Role In Gastrointestinal Disorders: An Analytical Study Of The Effect Of Pectin In Alleviating Diarrhea, Hamza A Saadallah, Mohammed. Ahb. Al-Krdoshi, Noor M Sultan, Farah Y Gaddawi, Marwa R. S Al Shaaban, Abd Al-Bar Al-Farha, Safa M Salim
Grated Green Apple And Its Therapeutic Role In Gastrointestinal Disorders: An Analytical Study Of The Effect Of Pectin In Alleviating Diarrhea, Hamza A Saadallah, Mohammed. Ahb. Al-Krdoshi, Noor M Sultan, Farah Y Gaddawi, Marwa R. S Al Shaaban, Abd Al-Bar Al-Farha, Safa M Salim
BioMed Visions Journal
Gastrointestinal disorders, including diarrhea, represent a significant global health burden, necessitating the exploration of effective and accessible therapeutic strategies. Dietary interventions, particularly those containing soluble fibers such as pectin, have emerged as promising solutions due to their profound impact on gut health and its microbiota. This meta-analysis systematically reviews the current scientific understanding of the multifaceted role of pectin in alleviating diarrhea, with a particular focus on the unique contribution of grated green apple. The analysis delves into pectin's physicochemical properties and mechanisms of action—including water binding, modulation of the gut microbiota, production of short-chain fatty acids, and support of …
Lig1 Loss In Tp53-Mutant Triple Negative Breast Cancer Rewires Dna Repair And Confers Sensitivity To Parp-Atr Inhibitor Combinations, Anh Minh Tran Huynh, Jonathan T Lei, Rachel Brough, Christina Sallas, Jun Xu, Jacob B Pilcher, Xuxu Gou, Junkai Wang, Lacey E Dobrolecki, Diana M Fandino, Mariah J Berner, Allison Greer, Fei Fei Song, Sarah Latka, Hugo Villanueva, Sumimasa Arimura, Sufeng Mao, Zhongqiu Guo, Sofía I Aramburu, Anran Chen, Thanh Nguyen, Carolina Gutierrez, Dolores H Lopez-Terrada, Bora Lim, Susan G Hilsenbeck, Michael T Lewis, George Miles, Jason C Mills, Gloria V Echeverria, Stephen J Pettitt, Simon N Powell, Susan M Rosenberg, Andrew N J Tutt, Christopher J Lord, Matthew J Ellis, Meenakshi Anurag
Lig1 Loss In Tp53-Mutant Triple Negative Breast Cancer Rewires Dna Repair And Confers Sensitivity To Parp-Atr Inhibitor Combinations, Anh Minh Tran Huynh, Jonathan T Lei, Rachel Brough, Christina Sallas, Jun Xu, Jacob B Pilcher, Xuxu Gou, Junkai Wang, Lacey E Dobrolecki, Diana M Fandino, Mariah J Berner, Allison Greer, Fei Fei Song, Sarah Latka, Hugo Villanueva, Sumimasa Arimura, Sufeng Mao, Zhongqiu Guo, Sofía I Aramburu, Anran Chen, Thanh Nguyen, Carolina Gutierrez, Dolores H Lopez-Terrada, Bora Lim, Susan G Hilsenbeck, Michael T Lewis, George Miles, Jason C Mills, Gloria V Echeverria, Stephen J Pettitt, Simon N Powell, Susan M Rosenberg, Andrew N J Tutt, Christopher J Lord, Matthew J Ellis, Meenakshi Anurag
Faculty, Staff and Students Publications
Proteogenomic analyses have identified an association between LIG1 (DNA Ligase I) loss and chemotherapy resistance in a subset of triple negative breast cancer (TNBC) enriched for TP53 mutations. Here, we demonstrate that co-occurrence of TP53 mutations and LIG1 loss is associated with upregulated DDR activity, including homologous recombination, likely contributing to reduced platinum sensitivity. Unbiased genetic and monotherapy drug screens identified PARP inhibitors (PARPi) as a potential treatment for LIG1-depleted tumors; however, the increase in sensitivity was modest and lower than that observed in TNBC models with homologous recombination deficiency. Subsequently, a screen of PARP inhibition in combination with each …
The Role Of Mental Health In Postoperative Complications: A Literature Review, Kayla Monet Alwahhamy, Abbas Rasoul Alwahhamy
The Role Of Mental Health In Postoperative Complications: A Literature Review, Kayla Monet Alwahhamy, Abbas Rasoul Alwahhamy
Iraqi National Journal of Medicine
Background: Currently, it is not standard practice to screen all surgical patients both pre- and postoperatively for either a prior history of mental health disorders (MHD) or active symptoms of MHD at the time of surgery. This is despite growing evidence that MHDs may impact wound healing and are recognized as a mortality risk factor in many patients. Aim: This review aims to evaluate existing literature examining mental health (MH) in surgical patients, assess whether there is a relationship between MHDs and postoperative complication rates, and determine whether outcomes differ based on the timing of MHD manifestation (pre- …
Clearing The Air: Tracking Spatial And Temporal Pm2.5 Variability Along A Biking Transect In Chicago, Beau R. Rass
Clearing The Air: Tracking Spatial And Temporal Pm2.5 Variability Along A Biking Transect In Chicago, Beau R. Rass
DePaul Discoveries
Fine particulate matter (PM₂.₅) poses significant risks to human health and disproportionately affects marginalized communities in urban environments (World Health Organization [WHO], 2021; Tessum et al., 2021). Using low-cost mobile sensors, this study explored spatiotemporal PM₂.₅ concentration patterns along a north–south transect of Halsted Street in Chicago. A 2B Technologies Portable Aerosol Monitor (PAM) mounted on a bicycle was used to continuously record PM₂.₅ concentrations with associated GPS coordinates at approximately two-second intervals during 16 sampling events between 08-12-2025 and 10-05-2025. PM₂.₅ concentrations did not differ significantly among the South Side, West Loop, and North Side regions, contrary to the …
Comparable Outcomes, Divergent Learning Pathways: Comparing Metacognitive Reflection And Practice Problems In Organic Chemistry, Jitendra D. Belani
Comparable Outcomes, Divergent Learning Pathways: Comparing Metacognitive Reflection And Practice Problems In Organic Chemistry, Jitendra D. Belani
College of Life Sciences Faculty Papers
Organic Chemistry I presents significant challenges for students, requiring both conceptual understanding and effective study strategies. Two commonly used approaches to support learning are structured practice problems and metacognitive reflection activities; however, these strategies are rarely compared directly within the same course context. In this study, students enrolled in a postbaccalaureate Organic Chemistry I course (n = 31) were randomly assigned to one of two low-stakes interventions: weekly practice problem sets or structured reflection surveys focused on study strategies. Student performance was evaluated using three midterm examinations, a cumulative final exam, and overall course grades, along with measures of participation. …
Llm-As-A-Judge For Infection Prevention And Control And Antimicrobial Resistance Impact: Comparing Three Main Llms Vs. Human Experts' Assessment, Marcello Di Pumpo, Leonardo Villani, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Patrizia Laurenti, Vittorio Maio, Stefania Boccia, Walter Ricciardi
Llm-As-A-Judge For Infection Prevention And Control And Antimicrobial Resistance Impact: Comparing Three Main Llms Vs. Human Experts' Assessment, Marcello Di Pumpo, Leonardo Villani, Maria Rosaria Gualano, Danilo Buonsenso, Francesca Raffaelli, Daniele Donà, Patrizia Laurenti, Vittorio Maio, Stefania Boccia, Walter Ricciardi
College of Population Health Faculty Papers
BACKGROUND: Large language models (LLMs) are increasingly used to generate health information, yet their reliability as evaluators remains unclear. This study investigated the feasibility of an LLM-as-a-judge methodology in the context of infection prevention and antimicrobial resistance (AMR), comparing automated ratings with human expert benchmarks.
METHODS: We performed a secondary analysis of an expert-annotated dataset of health messages. Three leading LLMs (ChatGPT, Claude, Gemini) independently evaluated the same messages using an adapted DISCERN tool across five domains: information reliability, quality, AMR impact, persuasiveness, and overall score. We utilized descriptive statistics, intra-rater reliability tests, and mixed-effects ordinal regression to analyze divergence …
Feasibility Study Of An Artificial Intelligence Chatbot-Powered Cognitive-Behavioral Lifestyle Modification Program, Evans Forman, Charlotte Hagerman, Asher Hong, Zhuoran Huang, Hannah Mccausland, Jasmine Sun, Lauren Taylor, Meghan Butryn, Preetha Chatterjee, Ramtin Ehsani, Nawal Syed
Feasibility Study Of An Artificial Intelligence Chatbot-Powered Cognitive-Behavioral Lifestyle Modification Program, Evans Forman, Charlotte Hagerman, Asher Hong, Zhuoran Huang, Hannah Mccausland, Jasmine Sun, Lauren Taylor, Meghan Butryn, Preetha Chatterjee, Ramtin Ehsani, Nawal Syed
Department of Family & Community Medicine Faculty Papers
Background: Approximately 2 billion adults seek lifestyle modification to improve their health and well-being. However, because of cost and access barriers, only a tiny fraction receive gold-standard lifestyle modification programs led by trained coaches. Digital programs without human coaches are more disseminable but have limited efficacy. Recent advances in large language model (LLM) AI chatbots have the potential to revolutionize digital programs by emulating human coaches, offering a safe, low-cost, and scalable lifestyle modification intervention. Yet, no studies have developed and tested such a program. Purpose: This study aims to evaluate the feasibility, safety, and user engagement of a new …
Transforming Advising And Improving Outcomes: Assessing Impacts Of Advising Changes, Amy S. White, Tailisha Gonzalez, Elgloria Harrison
Transforming Advising And Improving Outcomes: Assessing Impacts Of Advising Changes, Amy S. White, Tailisha Gonzalez, Elgloria Harrison
Publications and Research
Abstract
Background: Earning full-time credit loads and persisting are how college students successfully graduate.
Objective: We measured whether credits and persistence at an urban, commuter Hispanic/Minority-Sserving Iinstitution improved after implementing a social work-based advisement strategy.
Methods: Using a quasi-experimental methodology on a college’s enrollment database, we measured the impact of a new advisement model on earned and attempted credit loads to compare traditional student advisement within control groups (n = 171 and n = 899) relative to intervention (n = 130).
Findings: In 2024, the intervention group attempted an average of 14.7 credits and earned an average of 14.3 credits, …
Evaluation Of Optimal Force For Intrusion Of A Periodontally Compromised Maxillary Anterior Dentition Treated With Fixed Orthodontics – A Finite Element Analysis, Tanzim Ahmed, Amrita Puri, Aatira Nair, Anshul Singla, Mathew Koshy Vaidyan, Shruti Sharma, Chhavi Singh
Evaluation Of Optimal Force For Intrusion Of A Periodontally Compromised Maxillary Anterior Dentition Treated With Fixed Orthodontics – A Finite Element Analysis, Tanzim Ahmed, Amrita Puri, Aatira Nair, Anshul Singla, Mathew Koshy Vaidyan, Shruti Sharma, Chhavi Singh
International Arab Journal of Dentistry
Introduction: Adult orthodontic treatment is increasingly sought due to aesthetic and functional concerns, often involving periodontally compromised patients with altered biomechanics. Reduced bone support shifts the center of resistance and necessitates lower, carefully controlled forces, while finite element modeling has become a key tool to analyze tissue response under such conditions.
Objectives: The study aimed to determine the optimal intrusive force for periodontally compromised maxillary anterior teeth using Finite Element Analysis (FEA).
Methods: A 3D finite element model of the maxillary anterior dentition was created and divided into healthy and compromised halves, the latter with one-third alveolar bone loss. A …
Employing Artificial Intelligence For Non-Invasive Diagnosis Of Craniofacial Deformities: A Systematic Review Of Non-Ionizing Radiation Methods, Nurul Mutmainnah, Harun Achmad, Lusy Damayanti
Employing Artificial Intelligence For Non-Invasive Diagnosis Of Craniofacial Deformities: A Systematic Review Of Non-Ionizing Radiation Methods, Nurul Mutmainnah, Harun Achmad, Lusy Damayanti
International Arab Journal of Dentistry
Introduction: Craniofacial deformities, like craniosynostosis and plagiocephaly, require early diagnosis, but traditional methods like CT scans use harmful ionizing radiation. Artificial Intelligence (AI) offers a non-invasive, radiation-free alternative, using 2D and 3D imaging for accurate diagnosis, improving safety and accessibility, especially in remote areas.
Objective: This review evaluates the use of AI in diagnosing craniofacial deformities without ionizing radiation, focusing on its strengths, limitations, and challenges in clinical implementation.
Methods: The literature was searched across five databases—PubMed, Google Scholar, ScienceDirect, Wiley, and Cochrane—over the last decade, following PRISMA guidelines. Inclusion criteria were AI-based, non-invasive imaging techniques for craniofacial deformities. The …
Influence Of Veneer Thickness On Double Bond Conversion Of Preheated Composite And Self-Adhesive Resin Cement Under Lithium Disilicate Restorations: An In-Vitro Study., Vanessa Kanaan, Marie Abboud, Alexandre Monnier, Dani Irani, Vana Mardirossian, Cynthia Kassis
Influence Of Veneer Thickness On Double Bond Conversion Of Preheated Composite And Self-Adhesive Resin Cement Under Lithium Disilicate Restorations: An In-Vitro Study., Vanessa Kanaan, Marie Abboud, Alexandre Monnier, Dani Irani, Vana Mardirossian, Cynthia Kassis
International Arab Journal of Dentistry
Introduction: This study evaluated the influence of lithium disilicate restoration thickness on the degree of conversion (DC) of a self-adhesive dual-cured resin cement (Bifix SE®; VOCO GmbH, Cuxhaven, Germany) and a preheated composite resin (VisCalor Bulk®; VOCO GmbH, Cuxhaven, Germany).
Methods: Sixty IPS e.max CAD (LTB1) specimens (2 mm, 4 mm, 6 mm; n D 10 per group) were fabricated and divided into six groups. Groups 1–3 were luted with Bifix SE, and Groups 4–6 with preheated VisCalor Bulk. Specimens were conditioned with 5% hydro_uoric acid and silane, then cemented and light cured. Raman spectroscopy was used to determine DC. …
Antibacterial Efficacy Of Resin-Based Dental Composites Modified With Antibacterial Agents Against S. Mutans: A Systematic Review, Ahmad Setiawan Jarigau, Erwin Gunawan, Muhammad Akira Takashi Dharma, Fanny Dinda Nur Aulia, Lenni Indriani Hatta, Nurhayati Natsir
Antibacterial Efficacy Of Resin-Based Dental Composites Modified With Antibacterial Agents Against S. Mutans: A Systematic Review, Ahmad Setiawan Jarigau, Erwin Gunawan, Muhammad Akira Takashi Dharma, Fanny Dinda Nur Aulia, Lenni Indriani Hatta, Nurhayati Natsir
International Arab Journal of Dentistry
Introduction: Dental caries caused by Streptococcus mutans is a leading cause of dental restoration failure. Enhancing composite resins with antibacterial agents aims to inhibit bacterial growth and prolong restoration life.
Objectives: This review evaluates the anti-bacterial agents efficacy of these modified composites against S. mutans and explores their mechanisms and potential clinical benefits.
Methods: A comprehensive literature search was conducted across multiple databases following PRISMA guidelines, focusing on in vitro studies published between 2015 and 2025. Studies evaluating composites with antibacterial additives against S. mutans using standard microbiological assays were included. The quality of eligible studies was assessed using the …
The Effectiveness Of Anterior Torque Control By Clear Aligners In Extraction And Non-Extraction Cases : Systematic Review, Houda Ousli, Kawtar Chadli, Fatima Zaoui, Hicham Benyahia
The Effectiveness Of Anterior Torque Control By Clear Aligners In Extraction And Non-Extraction Cases : Systematic Review, Houda Ousli, Kawtar Chadli, Fatima Zaoui, Hicham Benyahia
International Arab Journal of Dentistry
Introduction: Clear aligner treatment has gained popularity in recent years. Accurate torque expression of the upper incisors is crucial for orthodontic treatment outcomes but remains challenging in invisible orthodontic treatment.
Objectives: This systematic review aims to evaluate the existing literature and critically assess the clinical effectiveness of aligners in controlling anterior torque or bucco-lingual root inclination, in both extraction and non-extraction cases.
Methods: A systematic search of Scopus, PubMed, Web of Science, Ebsco, and the Cochrane Library was conducted for peer-reviewed articles published between 2014 and March 2025. A total of 257 records were identified (Scopus: 32; Web of Science: …
Enhancing Nursing Competency In The Ambulatory Surgery Center, Rachael Owokole
Enhancing Nursing Competency In The Ambulatory Surgery Center, Rachael Owokole
Walden Dissertations and Doctoral Studies
In this project, I addressed a persistent practice problem among agency nurses working in an ambulatory surgery center (ASC) in Southern California, who often enter the facility with varying familiarity with its policies and procedures. I designed this staff education, evidence-based practice (EBP), quality-improvement initiative to strengthen nursing knowledge and competency among agency nurses at the facility. The practice question was designed to assess on whether their knowledge and self-perceived competency improved after participating in the education program. I obtained evidence for the project from peer‑reviewed research, clinical guidelines, and national competency frameworks. I identified sources through systematic searches of …
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Signal And Substance: Why Methodological Sophistication Fails To Guarantee Inference, Aamir Rashid, Rizwana Rasheed
Publications and Research
Despite increasing analytical sophistication, empirical research in organization studies continues to suffer from fragile inference, uneven theoretical accumulation, and contested credibility. This paper seeks to explain why these problems persist by shifting attention from authors’ methodological choices to the evaluative dynamics of peer review. Adopting a conceptual and theory-analytic approach, the paper theorizes peer review as an inferential gatekeeping system. Drawing on research design, theory evaluation, and philosophy-of-science literatures, this study develops an analytical framework to examine how evaluative routines shape what constitutes empirical rigor during the review process. The analysis identifies five recurring reviewer blind spots: inferential scope inflation, …
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Decoding The Allosteric Grammar Of Protein Kinases: A Dual-Stream Framework Integrating Protein Language Models And Energy Landscape Frustration Analysis, Will Gatlin, Max Ludwick, Lucas Turano, Brandon Foley, Kamila Riedlova, Vít Škrhák, Marian Novotný, David Hoksza, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence-based artificial intelligence (AI) models. We present a protein language model (PLM)-guided approach complemented by the energy landscape frustration analysis as a dual-stream framework to investigate the relationship between AI prediction of binding sites and biophysical organization of regulatory pockets across the human kinome. By probing a fine-tuned residue-level PLM classifier across 453 kinase structures, a clear performance gap is discovered between highly predictable orthosteric pockets (Types I, I.5, and II) and poorly resolved distal allosteric sites (Type …
Antropometri Tangan Penduduk Kota Ambon Sebagai Dasar Perancangan Ergonomis, Puan Maryam Leaongso, Wilma Latuny, Aminah Soleman
Antropometri Tangan Penduduk Kota Ambon Sebagai Dasar Perancangan Ergonomis, Puan Maryam Leaongso, Wilma Latuny, Aminah Soleman
National Journal of Occupational Health and Safety
The limited availability of hand anthropometric data for the Indonesian population, particularly for the residents of Ambon City, may affect the accuracy of designing ergonomic products, work equipment, and public facilities. This study aimed to measure and analyze 25 hand dimensions of the Ambon City population based on gender and age, and to compare the measurement results with national anthropometric data. This research employed a quantitative method with a descriptive design through an anthropometric approach. Data were collected directly from 200 respondents, consisting of 100 females (aged 18–40 years) and 100 males (aged 20–40 years). Data analysis was performed using …
Unbiased Avidity-Based Isolation Of Antigen-Specific T Cells, Amanda Montoya, Meredith L Frank, Peixin Jiang, Hui Nie, Minying Zhang, Emily Bontekoe, Jared K Slone, Ludovica L Posta, Sofia Rosy Caterina Sorice, Tina Cascone, Maura Gillison, Don L Gibbons, Jianjun Zhang, Eleonora Dondossola, Lydia Kavraki, Pamela L Wenzel, John V Heymach, Alexandre Reuben
Unbiased Avidity-Based Isolation Of Antigen-Specific T Cells, Amanda Montoya, Meredith L Frank, Peixin Jiang, Hui Nie, Minying Zhang, Emily Bontekoe, Jared K Slone, Ludovica L Posta, Sofia Rosy Caterina Sorice, Tina Cascone, Maura Gillison, Don L Gibbons, Jianjun Zhang, Eleonora Dondossola, Lydia Kavraki, Pamela L Wenzel, John V Heymach, Alexandre Reuben
The Brown Foundation: Institute of Molecular Medicine
Background: Cancer immunotherapies have significantly improved treatment efficacy and patient survival by exploiting antigen-specific T cells to eliminate cancer cells. However, current approaches for identifying and isolating antigen-specific T cells typically require prior knowledge of target antigens, limiting discovery, and reducing the ability to consistently detect rare tumor-reactive T cells. We therefore sought to develop an unbiased platform for the identification and enrichment of antigen-specific T cells using naturally processed and presented tumor antigens.
Methods: We developed ATTACH (Assessment of T cells Tethered to Antigen Class I Histocompatibility), a microfluidic platform that applies controlled shear stress and leverages tumor cells …
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Online Decoding Of Rat Self-Paced Locomotion Speed From Eeg Using Recurrent Neural Networks, Alejandro De Miguel, Nelson Totah, Uri Maoz
Psychology Faculty Articles and Research
Objective. Accurate and reliable neural decoding of locomotion holds promise for advancing clinical applications such as rehabilitation and prosthetic control, as well as for understanding neural correlates of action. Recent studies have demonstrated successful decoding of locomotion kinematics across species in motorized treadmill settings. However, efforts to decode locomotion speed directly and continuously in more natural contexts—where pace is self-selected rather than externally imposed—are scarce, and those that exist generally achieve only modest accuracy and require intracranial implants. Here, we aim to decode self-paced locomotion speed non-invasively and continuously using cortex-wide electroencephalography (EEG) recordings from rats. Approach. We introduce an …
Penilaian Safety Climate Di Area Quarry Pada Pabrik Semen Di Indonesia, Andrizqa Andrizqa, Mufti Wirawan, Raden Ismail Haq, Asep Zaenal Muttaqien, Muhammad Arifin Ramzy Lubis
Penilaian Safety Climate Di Area Quarry Pada Pabrik Semen Di Indonesia, Andrizqa Andrizqa, Mufti Wirawan, Raden Ismail Haq, Asep Zaenal Muttaqien, Muhammad Arifin Ramzy Lubis
National Journal of Occupational Health and Safety
Work in the quarry area of the cement industry has a high risk of occupational accidents. Workers' understanding of the safety climate is important to prevent workplace accidents and injuries. This study aimed to assess the safety climate in the quarry area of a cement plant in Indonesia while identifying aspects that still require improvement. This study employed a descriptive quantitative approach using a questionnaire adapted from the Loughborough Safety Climate Assessment Toolkit (LSCAT). The sample consisted of all workers in the quarry area, including 49 permanent workers and 90 contract workers. The results showed that the average safety climate …
Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser
Biophysical Insights Into A Cryptic Ligand Site In The Hydrophobic Core Of Human Pcna, Alexis N. Dispensa, Sharon N, Greenwood, Jason Yang, Daniel E. Logatto, James Fusco, E. Railey White, Roderic G. Eckenhoff, Zhiwei Liu, Brian P. Weiser
Department of Anesthesiology Faculty Papers
Proteins contain small pockets that form due to imperfections in residue packing or the rotational and conformational movement of amino acids. In this work, we used the fluorescent probe 1-aminoanthracene (AMA) to detect a small ligand pocket in the hydrophobic core of human proliferating cell nuclear antigen (PCNA), which is a critical protein for DNA replication and repair. Fluorescence measurements of AMA reported that the core of PCNA had a dielectric constant (ε) of 4, which was very apolar and similar to cyclohexane (ε = 2). Protein mutagenesis, photoaffinity labeling, and molecular dynamics simulations localized the binding site for AMA …
Sleep Disturbances Affect Sleep Quality Of Hospitalized Adults, Tonjia Hardesty
Sleep Disturbances Affect Sleep Quality Of Hospitalized Adults, Tonjia Hardesty
Dissertations
Abstract
Background: Sleep disturbances affect the quality of sleep hospitalized adults experience, possibly extending patient recovery time. Treatment of insomnia frequently includes pharmacological interventions exposing patients to potential side effects, leading to negative patient outcomes. The purpose of this project was to determine if a sleep hygiene toolkit including eye masks, earplugs, advocacy cards, and removal of nicotine patches at bedtime would improve patient sleep quality without use of pharmacological interventions.
Methods: A descriptive observational design was used in this quality improvement (QI) project. A convenience sample of 37 (N =37) participants over the age of 18 years and …
Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang
Enhancing Well-Being: Implementing Weekly Social Interventions For Older Adults In Independent Living, Rosa Huang
Dissertations
Loneliness and social isolation significantly impact the physical and mental well-being of older adults. This quality improvement project implemented an eight-week social intervention designed to reduce loneliness and enhance well-being through weekly sessions incorporating mindfulness exercises, gratitude journaling, and structured socialization activities. The intervention was delivered by nursing students to a sample of residents in a Midwestern independent living community. While most standardized measures of loneliness and mood did not show statistically significant changes, the project resulted in a statistically significant increase in social network engagement as measured by the Lubben Social Network Scale-6 (LSNS-6). The findings suggest that group-based …
Multiple Event Segmentation Mechanisms In The Human Brain, Tan T Nguyen, Joset A Etzel, Matthew A Bezdek, Jeffrey M Zacks
Multiple Event Segmentation Mechanisms In The Human Brain, Tan T Nguyen, Joset A Etzel, Matthew A Bezdek, Jeffrey M Zacks
2020-Current year OA Pubs
The human brain segments continuous experience into discrete events, with theoretical accounts proposing two distinct mechanisms: creating boundaries at points of high
Artificial Intelligence In Pharmaceutical Care: Transforming Drug Discovery, Development, And Patient-Care Delivery, Abdulrahman G. Alharbi, Abdulrahman A. Aljabri
Artificial Intelligence In Pharmaceutical Care: Transforming Drug Discovery, Development, And Patient-Care Delivery, Abdulrahman G. Alharbi, Abdulrahman A. Aljabri
Saudi Medical Journal
The integration of artificial intelligence (AI) into pharmaceutical care represents a paradigm shift in healthcare delivery, offering unprecedented opportunities to revolutionize medication management, accelerate drug development, and enhance patient outcomes. This comprehensive review synthesized evidence from global literature (2021–2025) examining AI applications across drug discovery and development, clinical trials optimization, medication therapy management, and pharmacy operations. The AI demonstrated prediction accuracies of 86–98% in drug discovery, 80% improvement in clinical trial recruitment efficiency, and 32.7% increase in medication adherence over standard care. The global AI drug discovery market, valued at \$1.5 billion (2023), is projected to reach \$11.8 billion by …
Recent Advances In Sustainable Production Of Enriched Chicken Eggs: A Mini Review, Karim El-Sabrout, Ayman Abd El-Aziz
Recent Advances In Sustainable Production Of Enriched Chicken Eggs: A Mini Review, Karim El-Sabrout, Ayman Abd El-Aziz
Jurnal Ilmu Ternak Universitas Padjadjaran
Enriched or “designer” chicken eggs have emerged as an important category of functional foods aimed at improving human nutrition through dietary manipulation of laying hens. This mini-review summarizes recent advances in egg enrichment strategies, focusing on omega-3 fatty acids, vitamins, minerals, and antioxidant compounds. Omega-3 enrichment remains the most widely adopted approach, achieved through supplementation with flaxseed, fish oil, or microalgae, resulting in significant increases in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in egg yolk. Multi-nutrient enrichment, including selenium, vitamin E, and carotenoids, has also gained attention due to its potential in enhancing antioxidant capacity and health of hens …