Digital Commons Network^™

Promoting Scientific Impact At The Nih, Fred D. Ledley M.D.

CISI Publication

We are honored to offer our comments on Promoting Scientific Impact at the NIH in response to NOT-OD-26-087: Request for Information on Measuring and Rewarding Scientific Impact.

These comments are informed by my professional experience as the founding director of the Center for Integration of Science and Industry at Bentley University, which has a mission to “advance the translation of scientific discoveries for public value by engaging science, business, and policy in transdisciplinary dialogue, scholarship, and education.” Our approach is to bring together the perspectives of natural science, business, analytics, economics, law, and policy to better understand, and advance, the …

International Federation Of Clinical Neurophysiology Standardized Stereo-Electroencephalography Terminology, Birgit Frauscher, Guoping Ren, Chifaou Abdallah, Fabrice Bartolomei, Milan Brazdil, Francine Chassoux, Patrick Chauvel, Mark Cook, Beate Diehl, Guada Fernandez Baca Vaca, Stefano Francione, Vadym Gnatkovsky, Walter Gonzalez, Akio Ikeda, Jean Gotman, Julia Jacobs, Lara Jehi, Philippe Kahane, Hui Ming Khoo, Sam Lhatoo, Louis Maillard, Daniel Mansilla, Aileen Mcgonigal, Ioana Mindruta, Dang Khoa Nguyen, Piero Perucca, Ivan Rektor, Sylvain Rheims, Philippe Ryvlin, Stephan Schuele, Andreas Schulze-Bonhage, Margitta Seeck, Jaysingh Singh, Michael Sperling, Rainer Surges, Laura Tassi, Eugen Trinka, Manjari Tripathi, Shuang Wang, Samuel Wiebe, Gregory Worrell, Sandor Beniczky

Department of Neurology Faculty Papers

OBJECTIVE: Stereo-electroencephalography (SEEG) is an intracranial EEG methodology used in presurgical epilepsy evaluation to precisely delineate the epileptogenic zone and associated networks. Although established for decades, its global adoption has accelerated due to a favorable safety profile and clinical effectiveness. However, inconsistent terminology limits comparability of findings and multicenter collaboration. This guideline addresses this gap by providing standardized SEEG terminology based on international consensus.

METHODS: A working group of 41 experts appointed by the International Federation of Clinical Neurophysiology (IFCN) Executive Committee used a modified Delphi process to develop standardized terminology. The process included two meetings and four Delphi rounds, …

Implementation Readiness For National Cancer Survivorship Care Standards, Christiane J. El Khoury, Meera Gupta, Maryem Shirzadi, Heidi Dowst, Martha Mims, Maysa Abu-Khalaf, Hoda Badr

Kimmel Cancer Center Faculty Papers

IMPORTANCE: Cancer survivorship care is a growing public health priority, yet delivery remains variable across health systems. The National Standards for Cancer Survivorship Care provide a framework for high-quality care, but little empirical evidence exists regarding health system readiness to implement these standards in routine practice.

OBJECTIVE: To assess implementation readiness for the National Standards for Cancer Survivorship Care and identify perceived barriers to implementation.

DESIGN, SETTING, AND PARTICIPANTS: This real-time Delphi survey study was conducted from January to March 2025 at a National Cancer Institute-designated comprehensive cancer center. Participants were multidisciplinary experts involved in cancer survivorship care delivery, care …

Immune Reconstitution And Tolerance-Inducing Therapies As Promising Therapeutic Approaches In Multiple Sclerosis, Alireza Beheshti Maal, Mandana Kazem Arki, Seyed Massood Nabavi, Mostafa Rezaei-Tavirani, Elham Rismani, Massoud Vosough, Gholamreza Azizi, Nikoo Hossein-Khannazer

Department of Neurology Faculty Papers

OBJECTIVES: Multiple sclerosis (MS) is a complex, progressive neurodegenerative autoimmune disease and a major cause of neurological disability worldwide. MS affects approximately 2.8-3 million people, predominantly presenting as relapsing-remitting MS (RRMS) that frequently converts to secondary progressive disease, while effective options for progressive phenotypes remain limited.

METHODS: This review reframes MS immunotherapy through a tolerance-centric paradigm, distinguishing continuous maintenance disease-modifying therapies (DMTs) from immune reconstitution therapies (IRTs) and emerging antigen-specific tolerance strategies.

RESULTS: Classical immune reconstitution therapies, including alemtuzumab, cladribine, and autologous hematopoietic stem cell transplantation (aHSCT), have demonstrated durable disease control and prolonged periods of no evidence of disease …

Acemannan/Alginate Composite Hydrogels Promote Sto Cell Spreading And Metabolic Activity, Hong Yongxing, Tharasanit Theerawat

The Thai Journal of Veterinary Medicine

Alginate-based hydrogels are widely used as biocompatible scaffolds. However, their limited cell-adhesive properties restrict their application in tissue engineering. This study aimed to fabricate acemannan/alginate (ACE/ALG) composite hydrogels and evaluate their cytocompatibility and ability to support STO cell spreading and metabolic activity. Composite hydrogels were prepared by blending different concentrations of ACE with alginate, followed by Ca²⁺-mediated ionic crosslinking. Rheological analysis showed that ACE incorporation increased both the storage modulus (G′) and loss modulus (G″) of the hydrogels. Cell viability and morphology were evaluated using Live/Dead staining on day 7, and cellular growth was assessed using an MTT assay on …

Mertk Inhibition Cooperates With Immunomodulatory Cyclophosphamide To Induce Cxcl9⁺ Monocyte-Macrophage Programming And Durable Antitumor Immunity In Triple Negative Breast Cancer, Alex J Smith, Zachary Schrank, Nan Guan, Diego A Pedroza, Sebastian J Calderon, Xueying Yuan, Na Zhao, Zoe Gabriel, Yang Gao, Charlotte H Rivas, Fengshuo Liu, Jonathan S Serody, Charles M Perou, H Shelton Earp, Jeffrey M Rosen

Faculty, Staff and Students Publications

Triple-negative breast cancer (TNBC) has high rates of recurrence despite chemotherapy and immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) can either suppress or support antitumor immunity, but the mechanisms governing these states and therapeutic targets remain unclear. Here, integrating public scRNAseq datasets with TNBC cohorts, we identify a prognostic myeloid signature defined by CXCL9hi programs, associated with improved survival and enrichment of lymphocyte activation pathways. Using immunocompetent p53-null syngeneic TNBC models spanning basal-like (2153L) and claudin-low (T12) subtypes, we show that immunomodulatory cyclophosphamide (CTX) reprograms hematopoiesis toward the monocytic lineage and induces an interferon (IFN) conditioned tumor milieu that supports …

E-Health Literacy And Cyberchondria Severity Among Adolescent High School Students: A Cross-Sectional Study, Seyda Çavmak, Adem Bilgin

Makara Journal of Health Research

Background: Amid rapid digitalization and the growing use of artificial intelligence-based search engines, adolescents increasingly seek health information online. This study examined the relationship between high school students' e-health literacy and their cyberchondria tendencies.

Methods: This quantitative, cross-sectional study included 683 students from public high schools in Mersin, Türkiye. Data were collected using a Demographic Information Form, the e-Health Literacy Scale (eHEALS), and the Cyberchondria Severity Scale Short Form (CSS-12). Descriptive statistics, comparative tests, and Pearson correlation were applied (p < 0.05).

Results: Students' e-health literacy and cyberchondria severity were moderate. Significant positive correlations emerged between e-health literacy …

Comments Re: Medicare Drug Price Negotiation Program And Medicare Prescription Drug Benefit Program, Fred D. Ledley M.D., Edward Zhou Pharm. D.

CISI Publication

Thank you for the opportunity to provide written comments in response to the Medicare Drug Price Negotiation Program proposed rule published on June 16, 2026 in the Federal Register. [1] We are answering as academic researchers with experience in medicine, pharmacy, biomedical research, and the biopharmaceutical industry. Our perspective is informed by extensive, published research on the economics and finance of pharmaceutical innovation, the value created by new medicines, and the impacts of the Inflation Reduction Act (IRA).

We applaud the accomplishment of the IRA in establishing the precedent for the government to negotiate “fair market prices” for drugs on …

The Cul-De-Sac Paradox: The Relationship Between Walkability, Playability, And Children’S Physical Activity, Lydia Reader

McKelvey School of Engineering Graduate Student Theses & Dissertations

Walkability and playability are two constructs on how the built environment can support physical activity, the former most relevant to adults and the latter designed with children in mind. There are concerns that walkability and playability are intrinsically in competition with one another, with urban forms supportive of physical activity for adults detrimental toward the physical activity of children and vice versa. This thesis explores this conflict using agent-based modeling as a tool for refining the theoretical constructs behind playability and children’s physical activity. We examine the state of the current evidence for the relationship between walkability and children’s physical …

Data-Driven Staging Of Neurodegenerative Pathology Related To Alzheimer’S Disease, Thomas Earnest

McKelvey School of Engineering Graduate Student Theses & Dissertations

Alzheimer’s Disease (AD), the most common cause of dementia, is a dual proteinopathy exhibiting deposits of extracellular amyloid-beta (Aβ) and intracellular tau in brain tissue. Models which describe the spatial and temporal trajectories of these pathologies have been invaluable for understanding AD and have the potential to support diagnosis, disease monitoring, and treatment development. Disease staging systems, which provide protocols for assessing individual disease severity based on their extent of brain pathology, have been crucial for explaining and diagnosing AD. However, these systems have been primarily informed by post-mortem histological assessments and are not directly applicable to disease assessment in …

Modernizing Career Counseling In Counselor Education: A Conceptual Exploration, Yuhyun Park, Se Hoon Kim, Rasheed Adeyemo, Sarah Ebner, Mallory Redmond, Breeana Donayre, Carly Steves

Journal of Counselor Preparation and Supervision

Career development is often confined to a single course despite its relevance across counseling practice. This conceptual article reframes it as an integrative foundation for counselor preparation, supervision, and professional identity. It examines connections among work, mental health, education, disability, relationships, and social context across counseling specializations. The article also considers doctoral training and the ethical use of artificial intelligence in career-related practice. Recommendations address curriculum design, supervision, and future research on integrated career preparation.

Development Of An Ergonomic Education Program At The Nestlé Usa Production Facility In Nea, Virginia Smith

Occupational Therapy Doctoral Capstones

A review of the literature, needs assessment findings, and collaboration with site stakeholders identified opportunities to strengthen ergonomics education, improve occupational health literacy, and support a more comprehensive approach to workplace ergonomics through the development of evidence-based resources. The purpose of the doctoral capstone project was to develop the Nestlé Ergonomics Program by applying the Person-Environment-Occupation (PEO) Model to create evidence-based ergonomic resources that increase workplace ergonomics education, promote occupational health literacy, and reduce the risk of work-related musculoskeletal disorders among employees at the Nestlé USA Production Facility in Jonesboro, Arkansas.

Le Défi Mondial : Panorama Comparatif Des Soins Néonatals Au Maroc Et Aux États‑Unis, Manasi Joshi

NEXUS: The Liberty Journal of Interdisciplinary Studies

Cette étude comparative examine les soins néonatals au Maroc et aux États-Unis après un stage dans une clinique privée à Rabat. Bien que les pratiques médicales principales soient universelles, leur application varie dans différents pays selon les circonstances socio-économiques et culturelles. Basée sur des observations directes, des entretiens avec des professionnels de soins néonatals marocains et une analyse de la littérature sur ce sujet dans ces deux pays, cette recherche discute de quatre différences principales : la disponibilité des ressources, l’accès aux soins de qualité, l’influence culturelle et les obstacles financiers. Malgré la pénurie évidente de personnel dans les hôpitaux, …

Cultivating Civility: A Multicomponent Approach To Reducing Workplace Incivility In An Assisted Living Facility, Sanam Bral, Kaylyn Chang, Catherine Dinh, Sanjil Kumar, Truc Mai Moon

Master's Projects and Capstones

Workplace incivility remains a common challenge in healthcare, negatively affecting communication, staff well-being, and the quality and safety of resident care. Baseline survey findings from a faith-based assisted living facility in Southern California identified concerns related to workplace incivility, psychological safety, and gaps in staff knowledge of available reporting resources. This project aimed to reduce workplace incivility by improving staff knowledge and recognition of uncivil behaviors, with a target of at least 90% staff training attendance among nursing, assistive nursing, and medical technicians, and 80% attendee-reported high confidence level (agree or strongly agree) in recognizing incivility and understanding reporting options. …

For Weight Loss: Why Do Glp-1 Agonists Work, And How Can We Make Them Work Better?, Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu

Children’s Nutrition Research Center Staff Publications

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-mediated weight loss and the enhanced efficacy of next-generation therapies remain. In this comprehensive review article, we first examine the milestones of GLP-1, from its initial discovery and biological characterization to its successful translation into clinical therapy. Furthermore, this review highlights the latest clinical trial data, specifically HbA1c reduction, weight-loss efficacy, and safety profiles, while exploring current pipelines of major pharmaceutical companies. Additionally, we delineate the mechanistic …

Rickettsia Africae Discovered In A Short-Term Urban Traveller To South Africa: A Case Report, Zunairah Sikder

Binghamton University Undergraduate Journal

Rickettsia Africae is a pathogen that causes African tick-bite fever (ATBF). Transmission typically occurs from ticks within the Central and South African regions. Previous studies suggested that ATBF is not uncommon amongst travelers to rural sub-Saharan Africa, especially during the rainy months of November through April. However, this case report highlights a woman who contracted ATBF in novel conditions. The 70-year-old woman reported travelling strictly to and from the local church and hotel for her four-day stay in July. After returning to America, the patient experienced extreme irritation on her arm, as well as complaints of headaches. She presented to …

A Message From The Managing Editor, Carissa Bayack

Binghamton University Undergraduate Journal

A message from the 2025-2026 Managing Editor of the Binghamton University Undergraduate Journal, Carissa Bayack.

Advancing Occupational Therapy Practice: Evaluating A Continuing Education Module To Support The Integration Of 3d Printing Into Clinical Care, Sophia Wilkes, Rebecca Ozelie

Student Journal of Occupational Therapy

This study aimed to evaluate whether a continuing education module could improve occupational therapy practitioners’ perceived knowledge, awareness, confidence, and clinical utilization of 3D printing in occupational therapy practice, while also examining how access to resources may influence implementation A 14-week cross-sectional pre–post design was used with occupational therapy practitioners participating in a one-hour educational session followed by a three-week trial of 3D printer access. Participants completed pre- and post-surveys assessing perceived knowledge, awareness, and confidence, and maintained a utilization log to track clinical use.

Results indicated a statistically significant increase in perceived knowledge and awareness of 3D printing following …

Face Mask Littering: Environmental Impacts, Regulatory Challenges, And Ai-Driven Waste Management Strategies For The Post-Pandemic Era, Pri̇yanka Rathee, Sari̇ta Khatkar, Renu Sehrawat, Pooja Rathee, Anurag Khatkar, Esra Küpeli̇

Turkish Journal of Medical Sciences

The widespread use of polypropylene-based face masks during the COVID-19 pandemic created a significant and persistent source of plastic pollution. This review aims to provide an integrative assessment of the environmental, toxicological, and public health implications of face mask litter and evaluate current waste management challenges and emerging technological solutions in the postpandemic context. A narrative review approach was employed, synthesizing literature published between 2020 and 2025 and indexed in major scientific databases including Web of Science, Scopus, and PubMed. Studies were selected based on their relevance to the issues of environmental contamination, microplastic generation, toxicological effects, regulatory frameworks, and …

C-Reactive Protein–Albumin–Lymphocyte (Cally) Index As A Novel Inflammatory Marker For Sarcopenia: Evidence From A Cross-Sectional Study ​, Yasemi̇n Polat Özer, Merve Güner, Serdar Ceylan, Engi̇n Çeşmeci̇, Cafer Balci, Burcu Balam Doğu, Meltem Gülhan Hali̇l, Mustafa Cankurtaran, Mert Eşme

Turkish Journal of Medical Sciences

Background/aim: Sarcopenia is a geriatric syndrome characterized by progressive impairments in skeletal muscle mass and performance, with chronic low-grade systemic inflammation playing a pivotal role in its development. The C-reactive protein–albumin–lymphocyte (CALLY) index reflects inflammatory burden alongside immune and nutritional status; however, its association with sarcopenia in older populations has yet to be sufficiently elucidated. The present study investigates the relationship between CALLY index values and probable sarcopenia (PS) in a large cohort of geriatric outpatients.

Materials and methods: Included in this retrospective cross-sectional study were 2042 geriatric outpatients aged ≥65 years who were assessed between May 2022 and March …

Association Of Occupational Lead Exposure With Erythrocytic Parameters And Nitric Oxide–Related Metabolites: A Case-Control Study ​​, Meli̇h Gaffar Gözükara, Servet Bi̇rgi̇n İri̇taş, Deni̇z Özkan Vardar, Lütfi̇ye Tutkun, Özlem İri̇taş, Serdar Deni̇z, Vugar Ali̇ Türksoy, Engi̇n Tutkun

Turkish Journal of Medical Sciences

Background/aim: Occupational lead (Pb) exposure remains a significant public health concern due to its persistent presence in industrial environments and its cumulative toxic effects. Although the hematological and neurological consequences of Pb exposure are well documented, early vascular effects and the mechanisms associated with potential endothelial impairment remain unclear. This study aimed to investigate the associations between Pb exposure, erythrocytic parameters, and nitric oxide (NO)–related metabolites (asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA], arginine, homoarginine, and citrulline) to identify early biomarkers that may suggest impairment in NO-related pathways.

Materials and methods: This case-control study included a strictly selected cohort of 125 …

Histomorphological Changes In Human Septal Cartilage Stored In Different Preservation Solutions ​, Özlem Akkoca, Aki̇f Si̇nan Bi̇lgen, Harun Çoban, Fatma Aslan Yay, Zeynep Kaptan, Funda Balkiliç Akkaya, Rahmi̇ Kiliç, Sami̇ Engi̇n Muz

Turkish Journal of Medical Sciences

Background/aim: To assess the histopathological effects of three preservation solutions (70% ethanol, povidone-iodine, and ciprofloxacin) on human septal cartilage obtained during septoplasty and to compare their preservation characteristics for potential future graft applications. Optimal preservation of septal cartilage is clinically important because well-preserved grafts may reduce the need for secondary cartilage harvesting and the associated donor-site morbidity while facilitating reconstructive procedures during revision surgery.

Materials and methods: A total of 90 septal cartilage specimens obtained from 30 patients undergoing septoplasty were allocated to three preservation groups and stored in the designated preservation solutions at +4 °C. Samples were examined histologically …

Readability Of Dermatology Patient Education Materials: A Comparative Analysis Of Turkish Dermatology Association Brochures And Texts Generated By Chatgpt And Gemini ​, Ahmet Kağan Özdemi̇r, Bengü Reyhan Botsali Özdemi̇r, Akin Aktaş

Turkish Journal of Medical Sciences

Background/aim: In modern healthcare, patient education materials (PEMs) are essential for bridging the gap between clinical knowledge and patient understanding. However, in Türkiye, where 64.6% of the adult population possesses inadequate or problematic health literacy, traditional medical brochures often exceed recommended reading levels. This study aimed to evaluate and compare the readability of Turkish dermatology PEMs prepared by the Turkish Dermatology Association (TDA) with those generated by artificial intelligence (AI) models.

Materials and methods: A total of 68 TDA PEMs were analyzed. Readability was assessed using the Ateşman Readability Index. Responses were generated by AI models to questions extracted from …

Can Hydrolyzed Silk Fibroin Derived From Bombyx Hatayensis And Ozonized Gel Modulate Inflammatory And Angiogenic Responses In A Corneal Alkali Burn Model? ​​, Şule Barman Kaki̇l, Hamdullah Suphi̇ Bayraktar, Okan Soylu, İshak Gökçek, Meryem İlkay Karagül, Zehra Demi̇ray Asoğlu

Turkish Journal of Medical Sciences

Background/aim: The therapeutic effects of hydrolyzed silk fibroin derived from Bombyx hatayensis and a commercially available ozonized gel, administered individually and in combination, were evaluated in a rat model of corneal alkali burn.

Materials and methods: A standardized corneal alkali burn was induced in the right eyes of Wistar albino rats using 1 N sodium hydroxide (NaOH). Animals were randomly assigned to six groups: negative control, positive control (PC), hydrolyzed silk fibroin (SF), ozonized gel (O), combined treatment (SF + O), and antibiotic treatment. Topical treatments were administered for 21 consecutive days. Clinical evaluation included assessments of corneal opacity, neovascularization, …

Antiobesity, Antidiabetic, And Antioxidant Activities Of Selected Rubia Species (Rubiaceae) And Lc–Ms/Ms-Based Chemical Profiling ​, Semi̇h Bulut, Ahmet Kahraman, Ayşenur Işik, Mustafa Abdullah Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rubia species (Rubiaceae) are recognized as medicinal and industrial plants exhibiting diverse biological activities. This study was conducted to evaluate the antioxidant, antidiabetic, and antiobesity potential of extracts prepared from Rubia davisiana Ehrend. (an endemic species), R. peregrina L., and R. rotundifolia Banks & Sol., which grow naturally in Türkiye.

Materials and methods: The antioxidant activity of 80% ethanol extracts prepared from the aerial parts was evaluated using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing power, metal chelating capacity, and total antioxidant capacity assays. Inhibition assays for α-glucosidase and α-amylase were performed to evaluate antidiabetic activity, …

Digital Markers For Passive Remote Monitoring Of Bipolar Disorder: Systematic Review, Thomas P Kutcher, Isha Chakraborty, Kristin Kostick-Quenet, Akane Sano, Nidal Moukaddam, Jeffrey A Herron, Wayne K Goodman, Sameer A Sheth, Ashutosh Sabharwal, Nicole R Provenza

Duncan NRI Faculty and Staff Publications

Background: Bipolar disorder (BD) features episodic shifts among mania, hypomania, depression, mixed states, and euthymia. Timely detection of mood transitions is difficult due to infrequent clinical touchpoints. Digital health technologies, including wearables and smartphones, offer a unique opportunity to passively and continuously monitor behavior and physiology that could reflect underlying mood dynamics in real-world settings.

Objective: This study aimed to systematically review passively collected digital markers for BD mood states, characterize devices/modalities and analytic approaches, appraise risk of bias, and identify design gaps and priorities for clinical translation.

Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) …

Effect Of Rangeland Quality On Rumen Development Of Angora (Mohair) Goat Kids And Bucks, Betül Zehra Sariçi̇çek

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine the effect of rangeland quality on the rumen development of Angora goat kids and bucks. Twenty male singleton Angora goat kids with similar birth dates and birth weights were selected from each farm in an area with three different rangeland quality levels (good, medium, or poor) in Ankara Province. The kids were weaned at 60 days of age and then grazed completely on rangeland until slaughter. Rumen volumetric and papillary development of animals slaughtered at 4 and 7 months of age were determined. Empty rumen length, width, and weight were affected by rangeland quality …

Full Issue, Volume 14, Number 1., Donna J. Peterson Dr., Scott Cummings, Elizabeth Gregory North

Journal of Human Sciences and Extension

No abstract provided.

Impact Of Acute Flight Training Stress On Cardiovascular Health: A Pilot Study, Toni Butler

Discovery Day - Daytona Beach

Impact of acute flight training stress on cardiovascular health: A pilot study  Toni C. Butler, Carolina R. P. Ferreira, Bryan W. Hinton, Noah J. Robbins, Sophia R. Vaden, Andrew H. Schneider, Scott K. Ferguson, Ph.D.   Cardiovascular conditions are among the most common medical issues in certificated pilots and a major source of certification scrutiny. Student pilots experience unique acute stressors during flight training that may influence both physiological and psychological health. Acute stress is known to affect cardiovascular function, including vascular endothelial health; however, the impact of flight training–related stress on cardiovascular function remains poorly characterized. This pilot study tested …

Impact Of Stress & Fatigue On Cardiovascular Function In Young Pilots: A Thematic Review, Swarna Manoj

Discovery Day - Daytona Beach

Impact of Stress & Fatigue on Cardiovascular Function in Young Pilots: A Thematic Review   Authors: Swarna Manoj, Scott Ferguson   Keywords: pilot, stress, fatigue, heart rate variability (HRV), cardiovascular disease (CVD) Aviation is expanding globally and young pilots are the major workforce, yet FAA protocols require mandatory ECG only from age 35, with annual cardiac screening after age 40. Over the past five years, a pattern of sudden cardiac arrests in pilots particularly aged 30-40 has urged safety concerns. Despite the existing literature examining fatigue, burnout, stress, sleep hygiene and circadian disruption, only few studies systematically examine how these factors impact …