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Enteric-Coated Fenoprofen In Large-Joint Osteoarthritis, Gilbert B. Bluhm, Harris H. Macilwain, Walter W. Offen

Henry Ford Hospital Medical Journal

Enteric-coated fenoprofen was compared with standard fenoprofen (Nalfon, Dista, Indianapolis, IN) in a randomized, double-blind, parallel, three-month trial of 113 outpatients (mean age, 64 years) with large-joint osteoarthritis. A previous study showed that enteric coating of fenoprofen reduces gastrointestinal microbleeding and may offer a safety advantage. Both treatments provided statistically significant improvement in pain measures (tenderness on pressure, pain at rest, pain with weight-bearing activity, and pain on passive motion). Adverse experiences were similar with both treatments and of an expected type, severity, and incidence for nonsteroidal anti-inflammatory drugs. Enteric-coated fenoprofen was found to be as effective and safe as …

Jack S. Guyton, Md, Cornelius E. Mccole

Henry Ford Hospital Medical Journal

No abstract provided.

Editorial: Responsibilities Of Authorship: Justification Of The Multiauthored Scientific Paper, Sarah Whitehouse, Raymond C. Mellinger

Henry Ford Hospital Medical Journal

No abstract provided.

The Social Class And Mental Illness Correlation: Implications Of The Research For Policy And Practice, Christopher G. Hudson

The Journal of Sociology & Social Welfare

Ongoing efforts to unravel the causal issues involved in the correlation between socioeconomic status and mental illness suggest that the hypothesis of a recursive or interactive relationship may be the most tenable, at least with the psychoses. Implications of this research are explored, with particular attention paid to the mental health costs of economic policies, the principles with which states allocate mental health resources, and the use of this knowledge-base in service planning.

Fibrinogen Birmingham: A Heterozygous Dysfibrinogenemia (Aα 16 Arg → His) Containing Heterodimeric Molecules, Kevin R. Siebenlist, J. T. Prchal, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes. Coagulability with thrombin approached 100% and varied directly with the time of incubation with the enzyme. High- performance liquid chromatography analysis of thrombin-induced fibrinopeptide release demonstrated retarded fibrinopeptide A (FPA) and fibrinopeptide B (FPB) release and the presence of an abnormal A peptide (FPA) amounting to 50% of the total. The same biochemical abnormalities were found in her asymptomatic father. Amino acid analysis and carboxypeptidase digestion of FPA demonstrated the substitution of His for Arg at …

Parentage Analysis With Genetic Markers In Natural Populations I The Expected Proportion Of Offspring With Unambiguous Paternity, R Chakraborty, T R Meagher, P E Smouse

Faculty, Staff and Student Publications

Recent studies indicate that polymorphic genetic markers are potentially helpful in resolving genealogical relationships among individuals in a natural population. Genetic data provide opportunities for paternity exclusion when genotypic incompatibilities are observed among individuals, and the present investigation examines the resolving power of genetic markers in unambiguous positive determination of paternity. Under the assumption that the mother for each offspring in a population is unambiguously known, an analytical expression for the fraction of males excluded from paternity is derived for the case where males and females may be derived from two different gene pools. This theoretical formulation can also be …

Inventing The Skin You Love To Test, Rick Weiss

Popular Press Items

No abstract provided.

Policy For Identifying And Assessing The Health Risks Of Toxic Substances, Maine Bureau Of Health

Maine Collection

Policy for Identifying and Assessing the Health Risks of Toxic Substances

by Norman T. Anderson, Environmental Toxicology Program, Division of Disease Control, Bureau of Health (February, 1988).

Contents: Section I: Introduction / Section II: Methods / Section III: Exposure Assessment / Section IV: Hazard Identification / Section V: Hazard Assessment / Section VI: Risk Characterization / List of Figures / List of Tables

Laminin Receptors For Neurite Formation, H. K. Kleinman, Roy C. Ogle, F. B. Cannon, C. D. Little, T. M. Sweeney, L. Luckenbill-Edds

School of Medical Diagnostics & Translational Sciences Publications

Laminin, a basement membrane glycoprotein promotes both cell attachment and neurite outgrowth. Separate domains on laminin elicit these responses, suggesting that distinct receptors occur on the surface of cells. NG108-15 neuroblastoma-glioma cells rapidly extend long processes in the presence of laminin. We report here that 125I-labeled laminin specifically binds to these cells and to three membrane proteins of 67, 110, and 180 kDa. These proteins were isolated by affinity chromatography on laminin-Sepharose. The 67-kDa protein reacted with antibody to the previously characterized receptor for cell attachment to laminin. Antibodies to the 110-kDa and 180-kDa bands demonstrated that the 110-kDa protein …

The Κ-Deleting Element: Germline And Rearranged, Duplicated And Dispersed Forms, Winfried B. Graninger, Paula L. Goldman, Cynthia C. Morton, Stephen J. O'Brien, Stanley J. Korsmeyer

Biology Faculty Articles

Human light chain genes are used in a κ before λ order. Accompanying this hierarchy is the rearrangement of a κ-deleting element (Kde) which eliminates the kappa locus before λ gene rearrangement. In approximately 60% of rearrangements the Kde recombines at a conserved heptamer within the J_κ-C_κ intron. We demonstrated that aberrant V/J rearrangements possessing apparent "N" nucleotides existed 5' to the J_κ-Kde rearrangements. This suggests that the Kde may selectively eliminate nonfunctional V/J alleles. A κ-producing cell that displayed the unusual finding of λ gene rearrangement demonstrated a rearranged Kde. This rearrangement was a …

Analysis Of The Virulence Of Streptococcus Mutans Serotype C Gtfa Mutants In The Rat Model System, Raul G. Barletta, Suzanne M. Michalek, Roy Curtis Iii

School of Veterinary and Biomedical Sciences: Faculty Publications

The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton protein which catalyzes the synthesis of a small glucan (1.5 kilodaltons) from sucrose (J. P. Robeson, R. G. Barletta, and R. Curtiss III, J. Bacteriol. 153:211-221, 1983). To investigate the role of the GtfA enzyme in virulence, we constructed S. mutans gtfA mutants from three cariogenic serotype c strains. A plasmid that carried an erythromycin resistance determinant and an internal fragment of the gtfA gene but that was unable to replicate in streptococci was used to transform S. mutans. The erythromycin-resistant transformants carried a partial duplication of the internal …

Mental Illness - Chapter 5 Of "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Chapter 5 of Counseling and the Demonic by Rodger K Bufford

Mental Disorders - Chapter 6 Of "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Chapter 6 of Counseling and the Demonic by Rodger K Bufford

Demonic Influence And Mental Disorders - Chapter 8 Of "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Chapter 8 of Counseling and the Demonic by Rodger K Bufford

Spiritual Interventions - Chapter 10 Of "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Chapter 10 of Counseling and the Demonic by Rodger K Bufford

Summary And Conclusion - Chapter 12 Of "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Chapter 12 of Counseling and the Demonic by Rodger K Bufford

Index - From "Counseling And The Demonic", Rodger K. Bufford

Counseling and the Demonic

Index from Counseling and the Demonic by Rodger K Bufford

Radiation And Society, Rosalyn S. Yalow

Journal of the Minnesota Academy of Science

We live in a world in which the perception of reality is too often confused with reality and there are few fields in which more confusion exists than in the popular perception of the hazards of exposure to low-level radiation and low-level radioactive wastes. Much of the fear of radiation has been generated by the association of radiation and radioactivity with nuclear explosions and nuclear war. So phobic is the fear that, in the United States at least, the old dream of "Atoms for Peace," including the use of nuclear reactors for power production and even the use of radioactive …

Legislative Network; Series I; File 90, Juanita Hunter

Juanita Hunter, RN & NYSNA Papers [1973-1990]

No abstract provided.

Outlook Magazine, Fall 1988

Outlook Magazine

No abstract provided.

1988 Apothecary, Southwestern Oklahoma State University

Apothecary

The Apothecary staff would like to take this opportunity to congratulate the seniors who successfully completed their three years of professional training at Southwestern. We trust that they will strive for excellence in all of their endeavors and that they will use the knowledge they have gained at Southwestern to make further advances in the pharmacy profession.

We would like to extend a note of appreciation to the Southwestern Oklahoma State University School of Pharmacy alumni and friends, the individual stores, and the companies whose generous contributions have made the publication of the 1988 Apothecary possible.

Santa Clara Magazine, Volume 30 Number 2, Winter 1988, Santa Clara University

Santa Clara Magazine

10 - UNDERSTANDING THE NEW SOVIETS A first-person account of the Soviet Union today by the author of two books on Russia. By Jim Garrison

16 - HOW TO GET INTO ADVERTISING An English graduate goes from waiting tables to a senior vice presidency on Madison Avenue. By Barbara Boyle

20 - 1988 ECONOMIC FORECAST For 15 years, Mario Belotti's been making forecasts that are amazingly accurate. By Mario Belotti

22 - SANTA CLARA AND THE POPES Reviewing historic links with Rome shows how it affected SCU. By Gerald McKevitt, S.J.

26 - SCU'S ETERNAL FLAIM Biology professor Frank Flaim …

Pms Or Perifollicular Phase Euphoria?, Mary Guinan

School of Public Health Faculty Research

Why is it that so little is known about PMS? First of all, there is no agreement on what PMS is. If investigators are referring to different sets of symptoms, how can studies be comparable? In fact, they are not. Not only are the symptoms different, but the timing of symptoms is different, Some studies describe symptoms that occur 7 to 10 days before the onset of menses, while others include symptoms that begin 14 days before the onset of menses and continue for 7 days after onset. This definition suggests that women may have PMS-related symptoms during 21 days …

Cloning And Sequencing Of The Genes For Shiga Toxin From Shigella Dysenteriae Type 1, Nancy A. Strockbine, Matthew Jackson, Lawrence Sung, Randall Holmes, Alison D. O'Brien

United States Public Health Resources

The structural genes for Shiga toxin, designated stx A and stx B, were cloned from Shigella dysenteriae type 1 3818T, and a nucleotide sequence analysis was performed. Both stx A and stx B were present on a single transcriptional unit, with stx A preceding stx B. The molecular weight calculated for the processed A subunit was 32,225, while the molecular weight of the processed B subunit was 7,691. Comparison of the nucleotide sequences for Shiga toxin and Shiga-like toxin I (SLT-I) from Escherichia coli revealed that the genes for Shiga toxin and SLT-I were greater than 99% homologous; three nucleotide …

Biotechnology And The Law: Social Responsibility V. Freedom Of Scientific Inquiry?, George P. Smith Ii

Scholarly Articles

At American University in Washington, D.C., on November 20, 1973, Julius Stone presented the tenth annual Mooers Lecture, entitled, "Knowledge, Survival, and the Duties of Science."' The central question and thesis that he propounded could and, indeed, should be raised anew today; they form the very core of the province and function of law, science, and medicine. In our brave new world they point to the leeways of choice and patterns of discourse that exist in grappling with the central issue of social responsibility in scientific inquiry. Perhaps they will assist in forging a consensus opinion for a subsequent course …

Treating Crazy People Less Specially, Stephen J. Morse

West Virginia Law Review

No abstract provided.

La3+-Induced Fusion Of Phosphatidylserine Liposomes. Close Approach, Intermembrane Intermediates, And The Electrostatic Surface Potential, Joe Bentz, D. R. Alford, J. Cohen, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

The fusion of large unilamellar phosphatidylserine liposomes (PS LUV) induced by La3+ has been monitored using the 1-aminoapthalene-3,6,8-trisulfonic acid/p-xylenebis(pyridinium bromide) (ANTS/DPX) fluorescence assay for the mixing of aqueous contents. The fusion event is extensive and nonleaky, with up to 95% mixing of contents in the fused liposomes. However, addition of excess EDTA leads to disruption of the fusion products in a way that implies the existence of metastable intermembrane contact sites. The maximal fusion activity occurs between 10 and 100 microM La3+ and fusion can be terminated rapidly, without loss of contents, by the addition of excess La3+, e.g., 1 …

Department Of Radiology - Annual Report July 1, 1987-June 30, 1988, David C. Levin

Department of Radiology Administrative Documents and Reports

107 page Department of Radiology Annual Executive Summary Report, July 1, 1987 to June 30, 1988, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States.

Table of Contents:

Name of Department and Chairman 1

Department Divisions and Directors 1

Department Faculty 2

Radiology Residents and Fellows 6

Departmental Committees and Memberships 7

Department Organization Charts 9

State of the Department 11

Teaching Programs 23

- A. Teaching Programs for Medical Students and Non-Radiology House Staff 23

- B. Residency Program for Residents in Radiology 25

- C. Training Programs for Fellows 27

Continuing Medical Education (CME) Programs 28

Radiology Grand Rounds …

Conduct Disorder And Cognitive Functioning: Testing Three Causal Hypotheses, Irvin Sam Schonfeld, David Shaffer, Patricia O'Connor, Stephanie Portnoy

Publications and Research

Studied the relation between cognitive functioning, as evidenced by IQ and achievement test performance, and Diagnostic and Statistical Manual of Mental Disorders (DSM-III) categories of conduct disturbance, using data from Black adolescents who were members of collaborative perinatal project from birth to age 7 yrs. At age 17 yrs, Ss and their parents were administered a battery of instruments that included standardized psychiatric diagnostic interviews as part of a call-back study. Analyses were compatible with the hypothesis that deficiencies in cognitive functioning are causally related to adolescent conduct disorder as defined by DSM—III. Results suggest that the relation of cognitive …

Neurokinin Regulation Of Midbrain Raphe Neurons: A Behavioral And Anatomical Study, Joseph Paris

Dissertations

No abstract provided.