Digital Commons Network^™

Enhancement Of Intratumor Antibody Distribution With A Bifunctional Antibody Delivery System And With Hyperthermia, Karen Lynn King

Loma Linda University Electronic Theses, Dissertations & Projects

The intratumor distribution of a new monoclonal antibody-hapten-based delivery system was examined. From two marine antibodies, Hybritech, Inc. has developed a bifunctional antibody (BPA) with specificities against CEA (ZCE-025 or GEM 231) and against one of two derivatives of [¹¹¹In]-benzyl-EDTA (CHA 255), EOTUBE or BLEDTA IV, to form ZCE/CHA or CEM/CHA. BFA accumulates in CEA-expressing tissue and clears from non-antigenic tissues prior to administration of an [¹¹¹In]-hapten.

Using five groups of nude mice bearing human colon tumor xenografts (T380), we evaluated different carriers of [¹¹¹In]-EOTUBE to prelocalized ZCE/CHA. We administered all antibodies and haptens …

Regulation Of Epidermal Growth Factor Receptor Synthesis By Retinoic Acid And Dexamethasone, Kerby C. Oberg

Loma Linda University Electronic Theses, Dissertations & Projects

Fetal rat lung (FRL) cells incubated in the presence of retinoic acid or dexamethasone exhibit altered ¹²⁵I-epidermal growth factor (EOF) binding capacity. Retinoic acid enhances ¹²⁵I-EGF binding 3-fold following 24 hours of 37° incubation. In contrast, FRL cells incubated in the presence of dexamethasone display a 2-fold reduction in ¹²⁵I-EGF binding capacity. The change in binding capacity, induced by either hormone, was due to alterations in the average number of receptors per cell as determined by Scatchard analysis of ¹²⁵I-EGF binding. In the absence of retinoic acid or dexamethasone, FRL cells were calculated to have approximately …

Anthropometric Parameters In Public School Students And Seventh-Day Adventist Vegetarian And Meat-Eating Students, Joan Sabaté-Casellas

Loma Linda University Electronic Theses, Dissertations & Projects

Concerns have been expressed for the ability of some vegetarian diets to support normal growth of children. Animal protein or meat intake showed a positive relationship to attained height in children from developing countries. In this study, the relationship between meat intake/vegetarian status and physical growth was investigated in children living in California.

Height and weight were collected on 2,272 Caucasian children aged 6-18 years attending Seventh-day Adventist (SDA) or public schools who participated in a two year longitudinal study. Age-, sex-, and school-specific mean heights and weights were at or above the national reference values. Sex-specific, age-adjusted regression analysis …

Autonomic Nervous System And Cholesterol Transport, Yuan-Line Hung

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of autonomic nervous system on cholesterol transport is of clinical interest because the relationship between lipoprotein metabolism and atherogenesis is expressed in coronary artery disease.

Generally speaking, beta blockers increase serum VLDL level but decrease both HDL and HDL₂ cholesterol levels without affecting the LDL in humans. We are unaware of reports concerning the effects of metoprolol on lipoprotein metabolism nor comparison of the effects of metoprolol and propranolol in the unhandled rat model. In part I we employed the unhandled rats to compared the effects of these 2 drugs administered with the drinking water in order …

Genes For Extracellular Matrix-Degrading Metalloproteinases And Their Inhibitor, Timp, Are Expressed During Early Mammalian Development, C. A. Brenner, R. R. Adler, D. A. Rappolee, R. A. Pedersen, Z Werb

Department of Obstetrics and Gynecology Research Publications

Extracellular matrix (ECM) remodeling accompanies cell migration, cell-cell interactions, embryo expansion, uterine implantation, and tissue invasion during mammalian embryogenesis. We have found that mouse embryos secrete functional ECM-degrading metalloproteinases, including collagenase and stromelysin, that are inhibitable by the tissue inhibitor of metalloproteinases (TIMP) and that are regulated during peri-implantation development and endoderm differentiation. mRNA transcripts for collagenase, stromelysin, and TIMP were detected as maternal transcripts in the unfertilized egg, were present at the zygote and cleavage stages, and increased at the blastocyst stage and with endoderm differentiation. These data suggest that metalloproteinases function in cell-ECM interactions during growth, development, and …

Louisiana State University Medical Center - 1989 - Spring Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1989 Spring Commencement of LSU Health Sciences Center - New Orleans held May 13, 1989.

Humanae Vitae And The Principle Of Totality, Ralph Mcinerny

The Linacre Quarterly

No abstract provided.

Current Literature, Catholic Physicians' Guild

The Linacre Quarterly

Material appearing below is thought to be of particular interest to Linacre Quarterly readers because of its moral, religious, or philosophic content. The medical literature constitutes the primary but not the sole source of such material. In general, abstracts' are intended to reflect the substance of the original article. Contributions and comments from readers are invited. (E. C. Laforet, M.D. , 2000 Washington St., Newton Lower Falls, MA. 02162.)

Children Raised By Homosexual Parents: Sexual Orientation, Mental & Sexual Health, Theresa Gramlich

Masters Theses & Specialist Projects

Sex and morals have often been factors in custody disputes. Courts have felt that giving custody of children to homosexual parents would create an environment not in the best interest of the child. Many mental health professionals argue that these decisions have been based on prejudice and homophobia. The purpose of this study was to evaluate research on the sexual orientation of children raised by homosexual parents and review data on the mental/psychosexual health of these children. These studies revealed no difference between children raised by gay/lesbian parents versus those raised by heterosexual parents on IQ scores, gender identity, or …

Contraception, Sexual Behavior, And Natural Law Philosophical Foundation Of The Norm Of Humanae Vitae, Martin Rhonheimer

The Linacre Quarterly

No abstract provided.

[Book Review Of] For The Patient's Good: The Restoration Of Beneficence In Health Care, By Edmund D. Pellegrino And David C. Thomasma, William Joseph Wagner

The Linacre Quarterly

No abstract provided.

An Analysis And Evaluation On Printed Materials Used In Genetic Counseling, Janet L. Macarthur

Community & Environmental Health Theses & Dissertations

The purpose of this study was to examine printed educational materials on five specific genetic disabilities and evaluate them for appropriateness of reading level and for inclusion of several specific issues related to the adequacy of the literature. Publicly available literature was analyzed using the Flesch-Kincaid Readability Formula and content analysis to estimate readability and to test for the presence of a definition of the disorder, a description of the basic genetics of the disorder and its symptomology, references to support groups and references for further information.

The data indicate that a definition of the disorder was included in 85% …

Self-Esteem And Perceived Barriers To And Benefits Of Exercise Among Physically Active And Non-Physically Active College Students, Barbara Brown Bonheur

Ellmer School of Nursing Theses & Dissertations

The purpose of this exploratory study was to examine differences in self-esteem, perceived benefits of and perceived barriers to exercise between exercisers and non-exercisers and to determine if relationships existed between self-esteem, perceived benefits of exercise and perceived barriers to exercise, that could explain participation in regular aerobic exercise. A sample of 105 university students completed four questionnaires. The level of social desirability present in participant responses was also measured. Five hypotheses were tested. Utilizing t-tests, a significant difference was found between exercisers and non-exercisers on self-esteem, perceived benefits of exercise, and perceived barriers to exercise. The three variables (self-esteem, …

The T(11;14)(P15;Q11) In A T-Cell Acute Lymphoblastic Leukemia Cell Line Activates Multiple Transcripts, Including Ttg-1, A Gene Encoding A Potential Zinc Finger Protein, Elizabeth A. Mcguire, Richard D. Hockett, Karen M. Pollock, Marty F. Bartholdi, Stephen J. O'Brien, Stanley J. Korsmeyer

Biology Faculty Articles

Interchromosomal translocations within lymphoid neoplasms frequently involve the antigen receptor genes. We cloned the breakpoints of the t(11;14)(p15;q11) in a CD3-negative T-cell acute lymphoblastic leukemia cell line (RPMI 8402) in order to identify new genes potentially involved in T-cell neoplasia. An extensive comparison of both breakpoints and their germ line counterparts indicated that an inadvertant recombinase-mediated break at chromosome segment 11p15 recombined with the delta T-cell receptor at 14q11. The derivative 11 breakpoint resembles a coding joint in which 11p15 rather than a variable region was introduced 5' to a D_δ1D_δ2J_δ1 intermediate rearrangement. Conversely, the …

Regeneration Of Meissner Corpuscles In Diabetic Mice Following Median Nerve Crush, Bonnie J. Forrester

Loma Linda University Electronic Theses, Dissertations & Projects

The hyperglycemic metabolic condition found in diabetes mellitus leads to the development of sensory neuropathies and causes delayed and incomplete neuronal regeneration. Diabetic sensory neuropathy has been shown to contribute to the impairment of light touch and low frequency vibratory perception. It is proposed that the regeneration of receptors that detect these sensations will be delayed and incomplete in diabetic animals with uncontrolled hyperglycemia. This study addresses the effects of diabetes on the regeneration of Meissner corpuscles, distal sensory endings that perceive light touch and low frequency vibration.

Corpuscles from 60 diabetic mice, and their age-matched, non-diabetic littermates, were examined …

Santa Clara Magazine, Volume 31 Number 3, Spring 1989, Santa Clara University

Santa Clara Magazine

10 - VISION Santa Clara's new president talks about his priorities for the University in the decade ahead.

15 - FAMILY IN CRISIS Is the Silicon Valley family an endangered species?

18 - DUBLIN: CITY OF 1,000 YEARS Today it is a bustling European capital. But progress has come at a price.

22 - GEORGE AND THE SILVER FOX A behind-the-scenes look at President and Mrs. Bush.

27 - WHO SHALL CARE .. . AND HOW? By 2020 every fourth American may be 65 or over.

Specificity Of The Cardiac Response To Conspecific Vocalizations In Chimpanzees, Gary G. Berntson, Sarah T. Boysen

Sentience Collection

Heart rate measures were used to examine the functional response of young chimpanzees and orangutans to acoustic stimuli, including white noise and chimpanzee vocalizations (threat, stress, and alarm). The initial response of the animals to all stimuli was characterized by a prominent cardiac deceleration and an increase in heart period variability. The deceleratory responses persisted with repeated presentations of the noise, stress, and alarm stimuli. In contrast, the response of chimpanzees to the conspecific threat stimulus reverted over trials to a notable cardiac acceleration. This acceleratory response was not attributable to potential patterns of evoked somatic responses. The features of …

Vital Signs, April 1989, Boonshoft School Of Medicine

Vital Signs

A twelve page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Smoking Cessation In Relapsed Smokers: A Competing Schedules Approach, Catherine E. Ellis

Masters Theses

Recent research in cigarette smoking reveals that social support and reinforcing alternative behaviors to smoking may be instrumental for sustained abstinence. This study examined the efficacy of these approaches with a group of relapsed smokers. Subjects were fifteen male and female Southwestern Michigan residents between the ages of 22-48. Both the treatment and control group attended two initial smoke-stopping sessions. The independent variable was a relapse-prevention package administered to the treatment group over the third through seventh sessions. Dependent variables were Carbon Monoxide (CO) levels, Saliva Thiocyanate (SCN) levels, and the daily number of cigarettes smoked. A two-way analysis of …

Menno-Knight, April 1989, Mennonite College Of Nursing

Menno-Knight

Student newsletter of the Mennonite School/College of Nursing.

Hypoxanthine-Induced Differentiation Of Cultured Human Leukemia Cells, Gayle Jennette Singleton

Chemistry & Biochemistry Theses & Dissertations

Human cultured leukemia cells appear to have a decreased amount of inosine in their tRNA. When cells with inosine deficient tRNA are placed in a hypoxanthine fortified media, they incorporate hypoxanthine into their tRNA by the action of the enzyme tRNA-hypoxanthine ribosyl transferase. This generates the nucleoside inosine in the tRNA. The cultured human leukemia cell lines, CCRF-CEM, HL-60, and HGPRT(-) HL- 60, incorporate hypoxanthine into their tRNA, as determined by tRNA isolation, hydrolysis, and HPLC analysis. Hypoxanthine treatment dramatically inhibited cell growth in conjunction with partial induction of differentiation in the CCRF-CEM, HL-60, and HGPRT ( - ) HL-60 …

Isolation And Partial Characterization Of Basic, Sperm-Specific, Nuclear Proteins In The Dog And Hampster, Richard William Hall

Biological Sciences Theses & Dissertations

The purpose was to determine whether dogs and hamsters contain the same sperm-specific protamine and testis specific proteins (TP) as other eutherian mammals previously studied. The proteins (protamine and TPs) were isolated from spermatids and mature spermatozoa, and were subjected to electrophoresis in an acid-urea, polyacrylamide gel system according to the procedure of Panyim and Chalkley (1962). The results indicated that, regardless of the anatomical location of sperm acquisition, acid precipitation technique, or denaturing agents used, epididymal and testicular samples from both the dog and hamster contained protamine in elongated spermatids and mature spermatozoa. The protamines from dogs and hamsters …

Edema Disease-Like Brain Lesions In Gnotobiotic Piglets Infected With Escherichia Coli Serotype 0157:H7, David H. Francis, Rodney A. Moxley, Cecile Y. Andraos

School of Veterinary and Biomedical Sciences: Faculty Publications

Gnotobiotic piglets inoculated with Escherichia coli serotype 0157:H7 strains that produced Shiga-like toxin II developed brain lesions similar to those observed in edema disease of swine, including arteriolar necrosis and malacia. Loss of ability to produce Shiga-like toxin II resulted in loss of ability to cause brain lesions.

1989 Spring No. 19, School Of Medicine Office Of Alumni Affairs

Medicinews

LSU Medicinews Number 19 Spring 1989 was edited by Russell C. Klein, and published by the LSU School of Medicine Office of Alumni and Continuing Education Services.

This issue consists of 24 pages.

Jefferson Alumni Bulletin – Volume Xxxviii, Number 3, Spring 1989

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XXXVIII, Number 3, Spring 1989

The Gibbon Scholars program, Page 2

The Jefferson scene, page 12

Class notes, Page 29

Ohio Academy Of Medical History Annual Meeting Program, March 11, 1989, Ohio Academy Of Medical History

Annual Conference Programs

This one page program is from the annual meeting of the Ohio Academy of Medical History held on March 11, 1989. The program details the events and presentations of the meeting.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Screening For Adenocarcinoma Of The Prostate, Brian J. Miles

Henry Ford Hospital Medical Journal

No abstract provided.

Jim Bindon's Review Of Tsuguyoshi Suzuki And Ryutaro Ohtsuka's Human Ecology Of Health And Survival In Asia And The South Pacific, Jim Bindon

Pacific Studies

No abstract provided.

Histopathologic Diagnosis And Classification Of Prostate Adenocarcinoma: Biologic Significance, Jill M. Peters, John D. Crissman

Henry Ford Hospital Medical Journal

Early diagnosis and accurate, biologically meaningful classification of prostate neoplasia remain important goals. The relation of evolving clinicopathologic concepts of histologic appearances to potential tumor progression is a major advance in classification of prostatic neoplasia. The criteria for recognizing incidental or "occult" stage A-l adenocarcinomas remain problematic in diagnosis, and focal neoplasms with little or no propensity to progression must be differentiated from cancers with a high likelihood of aggressive behavior. Current histologic grading systems in classifying prostate adenocarcinoma accurately identify two cancer subsets: 1) focal well differentiated tumors which rarely progress, and 2) diffuse poorly differentiated tumors which invariably …