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Anticoagulation And Elective Surgery., J. Spandorfer, G. Merli

Department of Medicine Faculty Papers

No abstract provided.

Nursing: A New Day, A New Way, Lin Zhan, Jane Cloutterback

New England Journal of Public Policy

The U.S. health care environment is changing rapidly. Its structure, financing, and delivery are being reconfigured toward an integrated system based on managed care. Increasingly, national interest in health promotion and disease prevention is moving care away from a disease-oriented, institutionally based model to a population-focused, wellness-oriented, and community-based system. Health care consumers are diversifying in age, ethnicity, and socioeconomic status. The approach emerging from these changes and others requires nursing to rethink, redesign, and retool its workforce to meet new challenges. This article analyzes nursing education, practice, and operations. The authors discuss the dilemmas and complexity of developing an …

Job Mobility Of Entry-Level Workers: Black And Latina Women In Hospital Corridors, Maria Estella Carrión

New England Journal of Public Policy

Based on data from interviews with fifteen black and fifteen Latina women in entry-level jobs, this article discusses job access strategies, patterns of job mobility, and barriers to upward job mobility for low-income minority women in the hospital industry. Concentrated in the lowest wage levels and job tiers, they are quite diverse in subgroup composition, in age, and in training requirements. The research confirms that deficiencies in schooling and skills remain the major obstacles minority women confront when they apply for hospital jobs and restrict their opportunities once they are within the hospital labor market. Efforts to provide training and …

Myelin-Associated Glycoprotein Interacts With Neurons Via A Sialic Acid Binding Site At Arg118 And A Distinct Neurite Inhibition Site, Song Tang, Ying Jing Shen, Maria Elena Debellard, Gitali Mukhopadhyay, James L. Salzer, Paul R. Crocker, Marie T. Filbin

Publications and Research

Inhibitory components in myelin are largely responsible for the lack of regeneration in the mammalian CNS. Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo. Here, we show that MAG’s sialic acid binding site is distinct from its neurite inhibitory activity. Alone, sialic acid–dependent binding of MAG to neurons is insufficient to effect inhibition of axonal growth. Thus, while soluble MAG-Fc (MAG extracellular domain fused to Fc), a truncated form of MAG-Fc missing Ig-domains 4 and 5, MAG(d1-3)-Fc, …

Mitotic Spindle Poles Are Organized By Structural And Motor Proteins In Addition To Centrosomes, Tirso Gaglio, Mary A. Dionne, Duane A. Duane A. Compton

Dartmouth Scholarship

The focusing of microtubules into mitotic spindle poles in vertebrate somatic cells has been assumed to be the consequence of their nucleation from centrosomes. Contrary to this simple view, in this article we show that an antibody recognizing the light intermediate chain of cytoplasmic dynein (70.1) disrupts both the focused organization of microtubule minus ends and the localization of the nuclear mitotic apparatus protein at spindle poles when injected into cultured cells during metaphase, despite the presence of centrosomes. Examination of the effects of this dynein-specific antibody both in vitro using a cell-free system for mitotic aster assembly and in …

Myocyte Apoptosis During Acute Myocardial Infarction In The Mouse Localizes To Hypoxic Regions But Occurs Independently Of P53, Shani Bialik, David Geenen, Isaac Sasson, Rendi Cheng, James Horner, Sydney Evans, Edith Lord, Cameron Koch, Richard Kitsis

Peer Reviewed Articles

Significant numbers of myocytes die by apoptosis during myocardial infarction. The molecular mechanism of this process, however, remains largely unexplored. To facilitate a molecular genetic analysis, we have developed a model of ischemia-induced cardiac myocyte apoptosis in the mouse. Surgical occlusion of the left coronary artery results in apoptosis, as indicated by the presence of nucleosome ladders and in situ DNA strand breaks. Apoptosis occurs mainly in cardiac myocytes, and is shown for the first time to be limited to hypoxic regions during acute infarction. Since hypoxia- induced apoptosis in other cell types is dependent on p53, and p53 is …

What's Happening: September 3, 1997, Maine Medical Center

What's Happening

No abstract provided.

Update - September 1997, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Cocaine Addiction: The Nemesis of Modern Culture

The Type 2 Iodothyronine Deiodinase Is Expressed Primarily In Glial Cells In The Neonatal Rat Brain, Ana Guadaño-Ferraz, Maria Jesus Obregón, Donald L. St. Germain, Juan Bernal

Dartmouth Scholarship

Thyroid hormone plays an essential role in mammalian brain maturation and function, in large part by regulating the expression of specific neuronal genes. In this tissue, the type 2 deiodinase (D2) appears to be essential for providing adequate levels of the active thyroid hormone 3,5,3′-triiodothyronine (T3) during the developmental period. We have studied the regional and cellular localization of D2 mRNA in the brain of 15-day-old neonatal rats. D2 is expressed in the cerebral cortex, olfactory bulb, hippocampus, caudate, thalamus, hypothalamus, and cerebellum and was absent from the white matter. At the cellular level, D2 is expressed predominantly, if not …

A Novel Polymorphism Of Fcgammariiia (Cd16) Alters Receptor Function And Predisposes To Autoimmune Disease, Jianming Wu, Jeffrey C. Edberg, Patricia B. Redecha, Vipin Bansal, Paul M. Guyre, Kimberly Coleman, Jane E. Salmon, Robert P. Kimberly

Dartmouth Scholarship

A novel polymorphism in the extracellular domain 2 (EC2) of FcgammaRIIIA affects ligand binding by natural killer (NK) cells and monocytes from genotyped homozygous normal donors independently of receptor expression. The nonconservative T to G substitution at nucleotide 559 predicts a change of phenylalanine (F) to valine (V) at amino acid position 176. Compared with F/F homozygotes, FcgammaRIIIa expressed on NK cells and monocytes in V/V homozygotes bound more IgG1 and IgG3 despite identical levels of receptor expression. In response to a standard aggregated human IgG stimulus, FcgammaRIIIa engagement on NK cells from V/V (high-binding) homozygotes led to a larger …

Analysis Of Bovine Herpesvirus 1 Transcripts During A Primary Infection Of Trigeminal Ganglia Of Cattle, Luis M. Schang, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

During an infection of nonneuronal cells, bovine herpesvirus 1 (BHV-1) gene expression proceeds in a well-defined cascade. Products of immediate-early (IE) genes are expressed first, and they activate expression of early (E) and late (L) genes. Although the same cascade is assumed to occur during an infection of neurons in trigeminal ganglia (TG) of cattle, no experimental data is available to support this hypothesis. Consequently, we analyzed BHV-1 gene expression in bovine TG at 1, 2, 4, 7, and 15 days postinfection (dpi). Infectious virus was detected in ocular swabs from 1 to 7 dpi but not 15 dpi. By …

Books Received And Book Notices, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Book Listing for the Vol 20, No 3 Edition of the Pacific Studies Journal

Sqt1, Which Encodes An Essential Wd Domain Protein Of Saccharomyces Cerevisiae, Suppresses Dominant-Negative Mutations Of The Ribosomal Protein Gene Qsr1., Dominic P. Eisinger, Frederick A. Dick, Elke Denke, Bernard L. Trumpower

Dartmouth Scholarship

QSR1 is an essential Saccharomyces cerevisiae gene, which encodes a 60S ribosomal subunit protein required for joining of 40S and 60S subunits. Truncations of QSR1 predicted to encode C-terminally truncated forms of Qsr1p do not substitute for QSR1 but do act as dominant negative mutations, inhibiting the growth of yeast when expressed from an inducible promoter. The dominant negative mutants exhibit a polysome profile characterized by 'half-mer' polysomes, indicative of a subunit joining defect like that seen in other qsr1 mutants (D. P. Eisinger, F. A. Dick, and B. L. Trumpower, Mol. Cell. Biol. 17:5136-5145, 1997.) By screening a high-copy …

Increased Focal Adhesion Kinase- And Urokinase-Type Plasminogen Activator Receptor-Associated Cell Signaling In Endothelial Cells Exposed To Asbestos, A Barchowsky, B M. Lannon, L C. Elmore, M D. Treadwell

Dartmouth Scholarship

Exposure of low-passage endothelial cells in culture to nonlethal amounts of asbestos, but not refractory ceramic fiber-1, increases cell motility and gene expression. These changes may be initiated by the fibers mimicking matrix proteins as ligands for receptors on the cell surface. In the present study, 1- to 3-hr exposures of endothelial cells to 5 mg/cm2 of chrysotile asbestos caused marked cell elongation and motility. However, little morphological change was seen when chrysotile was added to cells pretreated with either mannosamine to prevent assembly of glycophosphatidylinositol (GPI)-anchored receptors or with herbimycin A to inhibit tyrosine kinase activity. Affinity purification of …

Cell Signaling Pathways Elicited By Asbestos, B T. Mossman, S Faux, Y Janssen, L A. Jimenez, Cynthia Timblin, Christine Zanella, Jonathan Goldberg, Eric Walsh, Aaron Barchowsky, Kevin Driscoll

Dartmouth Scholarship

In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors, i.e., DNA-binding proteins involved in modulating gene expression and DNA replication, are stimulated after exposure of lung cells to …

Qsr1p, A 60s Ribosomal Subunit Protein, Is Required For Joining Of 40s And 60s Subunits., Dominic P. Eisinger, Frederick A. Dick, Bernard L. Trumpower

Dartmouth Scholarship

QSR1 is a recently discovered, essential Saccharomyces cerevisiae gene, which encodes a 60S ribosomal subunit protein. Thirty-one unique temperature-sensitive alleles of QSR1 were generated by regional codon randomization within a conserved 20-amino-acid sequence of the QSR1-encoded protein. The temperature-sensitive mutants arrest as viable, large, unbudded cells 24 to 48 h after a shift to 37 degrees C. Polysome and ribosomal subunit analysis by velocity gradient centrifugation of lysates from temperature-sensitive qsr1 mutants and from cells in which Qsr1p was depleted by down regulation of an inducible promoter revealed the presence of half-mer polysomes and a large pool of free 60S …

Jefferson Alumni Bulletin – Volume Xlvi, Number 4, September 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVI, Number 4, September 1997

University Awards Honorary Degree to Dr. Davis, Page 5

Luscombe, miller, and Staas Receive the Alumni Achievement Awards, Page 6

Clinic Presentations Address a Range of Fields, Page 8

Receptions Across Country Welcome College Leaders, Page 12

Landmark Diabetes Prevention Program, Page 21

Cardiology and Cardiothoracic Surgery Reception, Page 25

Annual Giving Tops $1.7 Million, Page 30

Intrinsic And Extrinsic Control Of Hemopoietic Stem Cell Numbers: Mapping Of A Stem Cell Gene, Gerald De Haan, Gary Van Zant

Markey Cancer Center Faculty Publications

We evaluated in vivo interactions between extrinsic (growth factor induced) and intrinsic (genetically determined) effectors of mouse primitive hemopoietic stem cell proliferation and numbers. Accordingly, stem cell frequency and cell cycle kinetics were assessed in eight strains of inbred mice using the cobblestone area–forming cell (CAFC) assay. A strong inverse correlation was observed between mouse lifespan and the number of autonomously cycling progenitors (CAFC day 7) in the femur. The population size of primitive stem cells (CAFC day 35) varied widely (up to sevenfold) among strains, unlike total CAFC day 7 numbers (cycling and quiescent), which were similar. Administration of …

Louisiana State University Medical Center - 1997 - Summer Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1997 Summer Commencement of LSU Health Sciences Center - New Orleans held August 09, 1997.

The Relationship Of Health-Promoting Behaviors To Hospital Admissions In Adults With Congestive Heart Failure, Debbie Mcfalls

MSN Research Projects

Successful medical treatment for acute health conditions has precipitated an increase in the number of chronic health problems. One such chronic condition is congestive heart failure. Heart failure is the number one discharge diagnosis among Medicare recipients. The financial burden for the management of this chronic condition is astronomical. Health care providers are commissioned to manage this chronic illness prudently. The purpose of this correlational descriptive study was to determine if there was any relationship between health-promoting behaviors and readmission rates of adults with congestive heart failure. A convenience sample of participants was obtained from a hospital facility. Subjects were …

A Preliminary Analysis Of Health Lifestyles Between International Students And American Students At Western Kentucky University, Mei Zhu

Masters Theses & Specialist Projects

The purpose of this research was to assess the lifestyle of international students at Western Kentucky University (WKU) and to compare the lifestyles of international and American students and subgroups of international students. The Lifestyle Questionnaire (LSQ), was a 26-item personal health lifestyle test, which had six sections (nutrition, exercise, smoking, alcohol and drugs, safety, and stress). The test-retest reliability of LSQ was evaluated by Pearson Correlation Coefficient (r) and was .89. During October and November 1997, 55 international students and 64 American students at WKU finished the LSQ. Significant differences were found between the American student group and the …

Comparisons Of Outcomes In A Pediatric Primary Care Clinic In Patients Treated By A Physician Or A Nurse Practitioner, Ken Burnette

MSN Research Projects

Physician availability during the 2 0th century has waxed and waned. During periods of physician shortage and surplus, there have always been underserved segments of our society. Nurse practitioners (NPs) have provided care for these underserved populations. Unfortunately, 30 years after the first NPs began to practice there remain underserved populations and underutilized practitioners. The purpose of this study was to compare outcomes between physicians and practitioners. The research questions are the following: Is there a difference in patient's satisfaction between care provided by a physician and a nurse practitioner? Does care differ when initiated by a physician or a …

Nurse Practitioners' Attitudes Toward Substance Abuse, Anabel P. Pereda

MSN Research Projects

Substance abuse is a major health problem in the United States today. The prevalence of the problem in primary health care settings mandates examination of the nurse practitioner's attitudes toward substance abuse. Research has demonstrated that the attitude of the health care provider toward the substance abuser can affect the level and quality of care rendered. This descriptive study was designed to examine the attitudes of nurse practitioners certified and practicing in Mississippi. Pender's revised Health Promotion Model was utilized as the theoretical framework for the study. The research question asked in this study was : What are the attitudes …

Bulletin - August, 1997, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

The Relationship Between Meaning In Life And The Occurrence Of Drug Abuse: An Epidemiological Retrospective Study, Ben Howard

Masters Theses & Specialist Projects

Humans have been using plant-derived drugs for as long as we have recorded history. Significant negative consequences related to drug abuse have occurred in the areas of health, social issues, family relations, legal systems, and economic productivity. The purpose of this study was to explore the relationship between meaning in life and drug abuse. An epidemiological, retrospective study was performed to compare personal meaning in life between individuals receiving inpatient treatment for drug abuse and a group of non-drug abusing controls. Study participants completed the Purpose-In-Life Test and Life Attitude Profile-Revised. On both instruments, the inpatient drug abusing subjects were …

The Beneficial Effect Of Vitamin E And Selenium During Experimental Chagas' Disease, Yue Hou

Masters Theses & Specialist Projects

The present study was conducted to determine if vitamin E and selenium could have a positive synergistic effect during experimental Chagas' disease. In the first phase of the study, 25 female C3HeB/FeJ mice were infected with a Brazil strain of Trypanosoma cruzi while receiving vitamin E supplementation of 0 IU/kg, 200 IU/kg, 400 IU/kg, 600 IU/kg, 800 IU/kg in their diets. In the second phase, 20 female C3HeB/FeJ mice were infected while receiving 400 IU/kg vitamin E plus selenium supplementation of 2 ppm, 4 ppm, 8 ppm, 16 ppm in their drinking water. The results demonstrate that vitamin E does …

The Clastogenic Effects Of Cyclophosphamide And A Sixty Hertz Electromagnetic Field On Bone Marrow Cells Of Cd-1 Mice, Kevin K. Block

Dissertations

Extremely low frequency (ELF) electromagnetic fields (EMF) have been correlated with the induction of cancer in a number of epidemiological studies (Feychting and Ahlbom, 1993; T,m and Lee, 1994; London e t al. 1991; Lovely et al., 1994; Tomenius, 1986; Wertheimer and Leeper, 1979, 1982). Two hypothesis were tested in the present study. The first hypothesis tested was that exposure to a 7.3 G magnetic field for 24 hours would increase the frequency of clastogenic and/or mutagenic events in bone m arrow cells of mice. The second hypothesis tested was that exposure to a 7.3 G magnetic field for 24 …

Contaminants Biologiques Dans Les Centres De Traitement Des Eaux Usées, Jacques Lavoie, Geneviève Marchand, Carole Pépin, Yves Beaudet, Guillaume Lachapelle

Rapports de recherche scientifique

No abstract provided.

A Cephalometric Study Of The Class Ii Correction Effects Of The Eureka Spring, Ernest L. Stromeyer

Loma Linda University Electronic Theses, Dissertations & Projects

The effect of the Eureka Spring appliance, was investigated on 37 consecutively treated, non compliant, bilateral Class II malocclusions, requiring at least 3 mm or more of additional molar correction. The mean pretreatment age of this sample was 13.9 years. All patients were treated by a single clinician utilizing the Eureka Spring. Lateral cephalographs were taken at start of orthodontic treatment (T1), at insertion of Eureka Springs (T2), and at removal of the Eureka Springs (T3). The average treatment interval between T2 and T3 was 4 months. Class II correction occurred almost entirely by dentoalveolar movement, 33% in the maxilla …

Overexpression Of The D-Alanine Racemase Gene Confers Resistance To D-Cycloserine In Mycobacterium Smegmatis, Nancy E. Caceres, N. Beth Harris, James F. Wellehan, Zhengyu Feng, Vivek Kapur, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

D-Cycloserine is an effective second-line drug against Mycobacterium avium and Mycobacterium tuberculosis. To analyze the genetic determinants of D-cycloserine resistance in mycobacteria, a library of a resistant Mycobacterium smegmatis mutant was constructed. A resistant clone harboring a recombinant plasmid with a 3.1-kb insert that contained the glutamate decarboxylase (gadA) and D-alanine racemase (alrA) genes was identified. Subcloning experiments demonstrated that alrA was necessary and sufficient to confer a D-cycloserine resistance phenotype. The D-alanine racemase activities of wild-type and recombinant M. smegmatis strains were inhibited by D-cycloserine in a concentration-dependent manner. The D-cycloserine resistance phenotype in the …