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Changes In Gabaa̳ Receptor Expression And Alterations In Ca⁺⁺/Calmodulin-Dependent Protein Kinase Ii Activity In A Hippocampal Neuronal Culture Model Of Epilepsy, Robert Eagan Blair

Theses and Dissertations

Expression levels of GABAA receptor subunits and activity of the Ca++ /calmodulin-dependent protein kinase II (CaM kinase II) enzyme system were evaluated in an in vitro hippocampal neuronal culture model of epilepsy. Treatment of hippocampal neuronal cultures with Mg++-free media for 3 hours results in the induction of an enduring "epileptic" state as evidenced by the expression of spontaneous recurrent seizure (SRS) discharge. The induction of the SRS activity was shown to be a N-methyl-D-aspartate (NMDA) receptor, Ca++-dependent mechanism (Sombati and DeLorenzo, J Neurophys., 73 (4), 1995). Significant and long-lasting decreases in mRNA expression for the GABAA α2 and α5 …

Faculty Publications 1997, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 767 publications.

Exclusion Mapping Of Polycystic Kidney Disease: A Third Locus, Eoin Thompson

Theses: Doctorates and Masters

The aim of this research was to perform exclusion on a rare form of hereditary autosomal dominant polycystic kidney disease (ADPKD). To-date, two genes for ADPKD have been identified: PKDI which has been localized to the short arm of chromosome 16 and PKD2 which has been localized to the long arm of chromosome 4. However, a small number of families have been reported that have not shown linkage to either of these two loci, thus suggesting the existence of at least one additional locus (PKD3). Two families that are affected with ADPKD and do not show linkage to PKDI or …

Validation Of The Barkemeyer-Callon-Jones Malingering Detection Scale: The Ability Of A Scale Differentiate Simulating Malingers From Controls And Prior Litigants From Those With No Litigation Experience Within A Sample Of Men Who Have All Suffered Chronic Low Back Pain, David Curnow

Theses: Doctorates and Masters

Chronic low back pain costs the community, and several authors have suggested that individuals often attempt to exaggerate chronic low back pain. Currently no reliable and valid scale for assessing malingering in chronic pain populations exists, and there is a large difference in opinion on the ability of experts using clinical judgment to detect malingering. The current study seeks to provide a validation for the BarkemeyerCallon-Jones Malingering Detection Scale (MDS) which has purported to be able to identify individuals attempting to malinger neurological conditions and pain. A simulation design was used, as in previous research, because it is difficult to …

Women's Perceptions Of Birth Centre Care: A Qualitative Approach, Karen Coyle

Theses: Doctorates and Masters

The purpose of this exploratory study was to describe women's perceptions of the care they received in a birth centre, compared to their previous experiences in a hospital. Australian statistics indicate that five percent of childbearing women now choose to receive care in a birth centre setting. Clinical outcomes of birth centre care are now well documented, but there is limited empirical data about women's experiences of this model of care. Seventeen women, who had recently given birth in a birth centre, and had previously experienced care in a hospital setting, were interviewed about their care experiences. Using content analysis, …

The Future Of The World Health Organization: What Role For International Law?, David P. Fidler

Articles by Maurer Faculty

No abstract provided.

Microbialpolitik: Infectious Diseases And International Relations, David P. Fidler

Articles by Maurer Faculty

No abstract provided.

A Descriptive Study Of Non-Accredited Athletic Training Programs, Donald Lee Bishop

Dissertations and Theses @ UNI

The purpose of the study was to describe the current status of non-accredited athletic training programs at four-year colleges and universities in relation to receiving future accreditation by the Commission on Accreditation of Allied Health Education Programs (CAAHEP).

Since it was first organized, the National Athletic Trainers' Association, Inc. (NATA) has continually sought to elevate the standards of its members. There were no certification or education requirements for athletic trainers until 1970. These requirements, once very broad and open-ended, have since been refined and delimited to ensure the highest quality for athletic trainers. The NATA has once again raised their …

Eating-Disorder Patterns In The Minnesota Multiphasic Personaity Inventory, Karen Baer-Barkley

Dissertations

Problem. Early intervention is crucial for effective treatment of eating disorders. While there have recently been many assessment tools developed specifically for eating disorders, a screening tool is still needed. This study sought to identify, in an eating-disordered sample, the existence of a v-shaped pattern on scales 4-5-6 of the MMPI, a commonly used general measure of psychopathology.

Method. The sample consisted of 356 females who were being treated for eating disorders through the HOPE program between 1989 and 1996. Past research on the MMPI has produced equivocal results on identifying significant patterns on the clinical scales. Since prior research …

Predicting The Severity Of Radiation Skin Reactions In Women With Breast Cancer, Davina Porock

Theses: Doctorates and Masters

Skin reactions are unavoidable side effects of radiotherapy for breast cancer that may limit the amount of treatment a patient is able to receive. As well, the discomfort associated with the treatment may negatively affect the patient's quality of life and their willingness to complete a course of treatment that typically extends over seven weeks. Prior literature suggests that variations in patients' tissue reactions to radiation may be related to Individual patient characteristics. Before health care providers can intervene to prevent or minimise skin reactions, a clinical model that helps predict which patients will experience more skin reactions is needed. …

The Meaning Of Quality In Living Service Environments: An Analysis Of The Experiences Of People With Disabilities, Elderly People And Service Workers, Ruth Marquis

Theses: Doctorates and Masters

The purpose of the study was to examine the experiences of both people with disabilities and elderly people and to identify their perceptions of quality as it relates to living in a service or being supported by a service to live in the community. The study was naturalistic in design and used a phenomenological approach and inductive analysis. It involved immersion in living services for a two year period, in-depth interviews with people living and working in services and participant observation. Fifty service users between the ages of twenty-one and ninety-six, and twenty-six service workers between the ages of twenty-six …

Relationship Between Self-Esteem, Eating Behaviors, And Eating Attitudes Among Female Collegiate Swimmers, Melissa Ann Fey

Dissertations and Theses @ UNI

The purpose of this study was to investigate the association between self-esteem and eating behaviors/attitudes among female collegiate swimmers. Specifically, the relationship between self-esteem as measured by the Rosenburg Self-Esteem Scale (1965) and eating behaviors/attitudes as measured by the Eating Attitudes Test (EAT-26) (Gamer, Olmstead. Bohr. & Garfinkle. 1982) was determined for a purposive sample of female collegiate swimmers at the University of Northern Iowa. A total of 24 subjects completed self-report measures on self-esteem and eating behaviors/attitudes. Subjects' Body Mass Index was also assessed. Pearson product-moment correlation was used to examine the relationship among the scores on the Rosenburg …

Development Of Rapid Assessment Protocols For Evaluating The Mental Health Status Of Incoming Bosnian Refugees In Waterloo, Iowa, Susan Renee Dobie

Dissertations and Theses @ UNI

The purpose of this study was to develop rapid assessment protocols to evaluate the prevalence of common symptoms of clinical depression and post-traumatic stress disorder in the adult Bosnian refugee population in Waterloo, Iowa.

An extensive literature review was conducted to research (a) refugeeism around the world, (b) causes of refugeeism, (c) the refugee experience, (d) refugee health challenges, (e) post-traumatic stress disorder in refugees, (t) depression in refugees, (g) acculturation stress in refugees, (h) rapid assessment procedures in public health, (i) rapid mental health assessments, (j) the case of refugeeism in the former Yugoslavia, (k) the history of refugeeism …

Pure-Tone Thresholds And Otoacoustic Emission Strength As A Function Of Language Delay In Children, Emily Ann Haisman

Dissertations and Theses @ UNI

This study investigated the relationship between ultra-high frequency hearing loss and delays in speech and language development in 10 language delayed children and 10 nonlanguage delayed children. The study utilized both pure-tone sensitivity measures and distortion product otoacoustic emission (DPOAE) strength to assess hearing capability. Behavioral audiometric thresholds were obtained at 250, 500, 1000, 2000, 4000, 8000, 10000, 12500, 16000, 18000, 19000, and 20,000 Hz with standard air conduction audiometry and ultra-high frequency air conduction audiometry. DPOAE strength was measured at approximately 1000, 1100, 1500, 2000, 2500, 3000, 4000, 5000, 6000, 8000, 12000, 16000, and 20000 Hz using a standard …

A Systematic Evaluation Of Methods To Separate X- And Y- Bearing Sperm, Jacquelyn Irving

Theses: Doctorates and Masters

This project was initiated to determine if was possible to enrich either X- or Y- bearing sperm, and hence to preselect the sex of a child. Two of the possible reasons why couple might want to select the sex of a child are firstly because of a family history of an X-linked recessive genetic disorder, which usually only affect sons, and secondly families who have had several children of one sex. For this study, men with three or more children of the same sex were recruited following the publication of an article in The West Australian newspaper. The percentage of …

Meperidine Attenuates The Secretion But Not The Transcription Of Il-1ss In Human Mononuclear Leukocytes, Donna O. Mccarthy, Susan Murray, Dawn Galagan, James E. Gern, Paul R. Hutson

College of Nursing Faculty Research and Publications

Background: The infusion of amphotericin-B (AmB) often produces clinically distressing rigors and chills, which promptly abate with intravenous injection of meperidine, although its mechanism of action is unknown.

Objective: To examine the effects of meperidine on the transcription or secretion of Interleukin 1β (IL-1β) in human mononuclear leukocytes (MNL) exposed in vitro to the lipopolysaccharide (LPS) contained inEscherichia coli endotoxin or to AmB.

Methods: Blood was drawn from eight healthy adult volunteers. The blood was centrifuged, and the layer containing MNL was separated; incubated with various combinations of medium, meperidine, and AmB; then tested for IL-1 content to determine …

School-Based Primary Prevention Programs For Eating Disorders, Suzanne D. Holmes

Graduate Research Papers

The primary purpose of this paper is to provide an extensive review of the literature and research related to anorexia nervosa, and to emphasize the importance of prevention programs in school settings and the role of school psychologists in the prevention and intervention process. Chapter two of this paper covers anorexia nervosa and the theories regarding its etiology, complications, co-morbidities, risk factors, and treatment. Because anorexia nervosa is a disorder which most frequently begins during adolescence, chapter three addresses the specific factors of adolescence that can lead to eating disorders.

Throughout the paper, there is an emphasis on the lack …

Louisiana State University Medical Center - 1997 - Fall Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 1997 Fall Commencement of LSU Health Sciences Center - New Orleans held December 11, 1997.

Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer

Pharmaceutical Sciences ETDs

Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …

Dentalgram - Vol. 11, No. 12, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Mt. Whitney trip
• Gallery
• In Memoriam
• Department news
• Student news
• For Your Information

Mutations In Yeast Proliferating Cell Nuclear Antigen Define Distinct Sites For Interaction With Dna Polymerase Δ And Dna Polymerase Ε, Joel C. Eissenberg, L. Rao Ayyagari, Xavier V. Gomes, Peter M.J. Burgers

Faculty Scholarship

The importance of the interdomain connector loop and of the carboxy-terminal domain of Saccharomyces cerevisiae proliferating cell nuclear antigen (PCNA) for functional interaction with DNA polymerases delta (Poldelta) and epsilon (Pol epsilon) was investigated by site-directed mutagenesis. Two alleles, pol30-79 (IL126,128AA) in the interdomain connector loop and pol30-90 (PK252,253AA) near the carboxy terminus, caused growth defects and elevated sensitivity to DNA-damaging agents. These two mutants also had elevated rates of spontaneous mutations. The mutator phenotype of pol30-90 was due to partially defective mismatch repair in the mutant. In vitro, the mutant PCNAs showed defects in DNA synthesis. Interestingly, the pol30-79 …

Maternal Age: Influence On Length Of Gestation And Birth Weight, Charlotte Bratcher

Masters Theses & Specialist Projects

The findings indicated no significant differences among the age groups in relation to infant birth weight nor in relation to the risk factors of smoking, maternal weight gain, trimester of first entry into prenatal care, or marital status They did indicate a significant difference [F(2,85) = 4.1364, p < .05] between the oldest and the youngest group (CD = 3.37, a = .05) in relation to gestational length. These findings are significant for healthcare providers in rural areas, since much of the previous research had been done in highly urbanized or inner city settings.

Characteristics And Resource Utilization Of Patients Of A Proprietary Home Health Agency In Rural South Central Kentucky, Linda Sewell

Masters Theses & Specialist Projects

The home health industry's introduction to managed care raises the prospect of reduced access to health care and poor outcomes for a vulnerable segment of our population—the rural elderly. Before effective intervention strategies can be accurately evaluated, a clearer picture of the sociodemographic features and home care service consumption is needed for this understudied group. The study was intended to provide a basis for future research into the evaluation of alternative methods of delivering effective care in terms of outcome and decreased cost for this population. A retrospective descriptive analysis was made of the patient record for the first six …

Bad Witches: A Cut On The Clitoris With The Instruments Of Institutional Power And Politics, Joan R. Tarpley

West Virginia Law Review

No abstract provided.

Full Issue, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Cultural Considerations In Clinical Reasoning: An Occupational Therapy Case Study, Sandra M. Winter

Masters Theses

This study looked at an occupational therapist's work with clients from varied cultural backgrounds. Qualitative research strategies and a phenomenological approach were used to gather data through interviews with a single respondent and observation of treatment. This methodology was used to examine the process utilized to acquire cultural knowledge and integrate that knowledge into treatment planning. Research focused on: (a) how the cultural background of a client influenced an occupational therapist as she planned and implemented treatment, (b) how the treatment process was influenced by cultural differences between the therapist and the client, and (c) how training or education helped …

Jefferson Alumni Bulletin – Volume Xlvii, Number 1, December 1997

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLVII, Number 1, December 1997 Annual Giving Celebrates a Half-Century of Strengthening Jefferson, Page 4 Screening for Breast Cancer: A Continuing Dilemma, Page 8 The McClellan house: A Link to the University’s Past, Page 12 The Bulletin Reaches its 75th Year, Page 17 Landmark Breast Cancer Meeting at Jefferson, Page 21 University and SmithKline Beecham Link Clinical Research, Page 22 Missing Cancer-Suppressor Genes May Have Deadly Effects, Page 23 Goldstein is Vice President for Research at JDFI, Page 27 Brezinski Develops Noninvasive Method to Detect Early Signs of Cancer and Heart Attacks, Page 29

Acknowledgements, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Direct Demonstration Of Retroviral Recombination In A Rhesus Monkey, Dawn P. Wooley, Randall A. Smith, Susan Czajak, Ronald C. Desrosiers

Neuroscience, Cell Biology & Physiology Faculty Publications

Recombination may be an important mechanism for increasing variation in retroviral populations. Retroviral recombination has been demonstrated in tissue culture systems by artificially creating doubly infected cells. Evidence for retroviral recombination in vivo is indirect and is based principally on the identification of apparently mosaic human immunodeficiency virus type 1 genomes from phylogenetic analyses of viral sequences. We infected a rhesus monkey with two different molecularly cloned strains of simian immunodeficiency virus. One strain of virus had a deletion in vpx and vpr, and the other strain had a deletion in nef. Each strain on its own induced low virus …

Update - December 1997, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- "Spirituality and Ethics in Patient Care"
-- Mind Manipulation: A Christian Ethical Analysis
-- Hobergs, Silk Hose, and Hypnosis