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Extensive Conservation Of Sex Chromosome Organization Between Cat And Human Revealed By Parallel Radiation Hybrid Mapping, William J. Murphy, Shan Sun, Zhang-Qun Chen, Jill Pecon-Slattery, Stephen J. O'Brien

Biology Faculty Articles

A radiation hybrid (RH)-derived physical map of 25 markers on the feline X chromosome (including 19 Type I coding loci and 6 Type II microsatellite markers) was compared to homologous marker order on the human and mouse X chromosome maps. Complete conservation of synteny and marker order was observed between feline and human X chromosomes, whereas the same markers identified a minimum of seven rearranged syntenic segments between mouse and cat/human X chromosome marker order. Within the blocks, the feline, human, and mouse marker order was strongly conserved. Similarly, Y chromosome locus order was remarkably conserved between cat and human …

A Preclinical Model Of Ionizing Radiation And Tnf-Alpha Gene Therapy For Cancer, Jun Li

Loma Linda University Electronic Theses, Dissertations & Projects

Long term control of high-grade brain tumors is rarely achieved with current therapeutic regimens. This study sought to determine if pretreatment with plasmid DNA expressing Tumor Necrosis Factor-α (TNF-α) could enhance the effect of ionizing radiation in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity in vivo, lesser toxicity and relatively low cost. We have constructed a plasmid-based mammalian expression vector (pGL1-TNF) to secrete human TNF-α from cancer cells. Plasmid DNA was successfully transfected into C6 cells …

Family And Child Psychosocial Functioning Of Infant Heart Transplant Recipients, Kimberly R. Freeman

Loma Linda University Electronic Theses, Dissertations & Projects

With the advancement of medical procedures, heart transplantation has become a viable alternative for infants born with congenital or acquired heart disease. Although these children are thought to experience much improvement in their overall physical functioning post-transplantation, the long-term psychological functioning of these children and their families is currently unknown. This study examines the long-term family functioning and psychosocial development of infant heart transplant recipients in comparison to children with congenital heart disease (CHD) and non-clinical control children. Results indicate that infant heart transplant recipients and their families experience fewer overall problems as compared to the CHD group, and more …

Genetic Control Of Eye Development, A Case Study Focused On The Murine Mutation Belly Spot And Tail (Bst), Qing Tang

Theses and Dissertations (ETD)

Development of the eye is controlled by a network of genes, often conserved, that regulate the timing and location of cellular differentiation. One approach to understanding this network of genes and their interaction is to focus on mutations, spontaneous or induced, that predictably disrupt the proper function of such networks, and by examining the effect of such disruption on the function of other genes.

The Belly spot and tail (Bst) semi-dominant mutation, mapped to mouse Chromosome 16, leads to developmental defects of the eye, skeleton, and coat pigmentation. In the eye, the mutant phenotype is characterized by the presence of …

Self-Esteem: The Impact Of A Course In Growth And Development On Fifth Grade Students, Mary Jang

Master's Projects

Teens in the United States have the highest pregnancy, abortion, and sexually transmitted disease rates among the developed countries. The social and financial costs of teen births are staggering. Research shows that high self-esteem is significantly related to resistance to group pressures, willingness to express unpopular opinions, family adjustment, creativity, and effective communication between parents and youth. The research question is: Will a 5-hour course in growth and development increase the level of self-esteem in fifth grade students? A convenience sample of 20 students (13 girls and 7 boys) who attend a public elementary school in San Jose, California, comprised …

Evaluation Of The Interface Pressure Of Conventionally Used Cushions By Sci Patient At The Ischial Tuberosites, Yiu-Chung Lau, Chau-Peng Leong, Hsueh-Wen Chang

Rehabilitation Practice and Science

Spinal cord injury (SCI) patients confined to a wheelchair for long periods are prone to pressure sores occurring at ischial tuberosity. This study used Expert-Seat pressure evaluation pad to record the pressure of the ischial tuberosities. Twenty-nine spinal cord injury subjects and twenty normal subjects participated in this study. The pressure distributed over ischial tuberosities during sitting was measured five times, including one measured without cushion. Four wheelchair cushions with different types of materials were evaluated in two population groups: spinal cord injured and normal control. The subjects sat on various types of wheelchair seats: (1) gel cushion: skil care …

A Ligand Binding Domain Mutation In The Mouse Glucocorticoid Receptor Functionally Links Chromatin Remodeling And Transcription Initiation, Lynn A. Sheldon, Catharine L. Smith, Jack E. Bodwell, Allan U. Munck, Gordon L. Hager

Dartmouth Scholarship

We utilized the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) in vivo to understand how the interaction of the glucocorticoid receptor (GR) with a nucleosome-assembled promoter allows access of factors required for the transition from a repressed promoter to a derepressed, transcriptionally competent promoter. A mutation (C644G) in the ligand binding domain (LBD) of the mouse GR has provided information regarding the steps required in the derepression/activation process and in the functional significance of the two major transcriptional activation domains, AF1 and AF2. The mutant GR activates transcription from a transiently transfected promoter that has a disordered nucleosomal …

Perceptions Of Couple Functioning Among Female Survivors Of Child Sexual Abuse, David Dilillo, Patricia J. Long

Department of Psychology: Faculty Publications

A sample of 51 college women retrospectively reporting a history of childhood sexual abuse and 91 women failing to report such a history was examined in order to investigate the relationship between victimization history and survivors' self-reports of functioning in adult intimate relationships. Specifically, relationship satisfaction, communication, and trust were examined in heterosexual relationships of at least six months' duration. As hypothesized, even when demographic differences between groups were controlled, survivors reported significantly less relationship satisfaction, poorer communication, and lower levels of trust in their partners than did women with no history of sexual abuse. The implications of these results …

Ada News - 11/15/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Elicitin-Mediated Plant Resistance, Joseph Chappell, Shaohui Yin, Catherine Cornett

Pharmaceutical Sciences Faculty Patents

Qualitative transcriptional regulatory sequences functional in plants, plant tissue and in plant cells for inducible gene expression and quantitative transcriptional regulatory sequences for increasing the transcriptional expression of downstream genetic information in plants, plant tissue and plant cells are disclosed. Also disclosed are methods and recombinant DNA molecules for improving the disease resistance of transgenic plants, especially wherein an inducible promoter controls the expression of a protein capable of evoking the hypersensitive response in a plant.

Why Are Girls Less Physically Aggressive Than Boys? Personality And Parenting Mediators Of Physical Aggression, Gustavo Carlo, Marcela Raffaelli, Deborah J. Laible, Kathryn A. Meyer

Department of Psychology: Faculty Publications

The primary goal of the present analysis was to determine whether the commonly observed gender difference in physical aggression could be accounted for by gender differences in selected personality and social contextual factors. Eighty-nine adolescents (M age = 16.0; 52% female; 53% European-Americans, 38% Latinos) completed self-report measures, including sympathy (empathic concern and perspective taking) and parental involvement (support and monitoring). Mediation analyses revealed that relatively high levels of both empathic concern and parental monitoring accounted for relatively low levels of physical aggression. In addition, sympathy (for males) and parental involvement (males and females) were negatively related to physical aggression. …

Do Mothers And Teens Disagree About Sexual Communication? A Methodological Reappraisal, Marcela Raffaelli, Lori A. Smart, Sarah C. Van Horn, Angela D. Hohbein, Jennifer E. Kline, Wei-Lik Chan

Department of Psychology: Faculty Publications

This study investigated whether parent-teen disagreement in reports of sexual discussions is due to methodological factors. Forty-four mothers and their 12- to 15-yearold daughters (n = 18) and sons (n = 26) completed parallel questionnaires including measures of communication about 18 different sexual topics during the teen’s entire life and during the past year. Analyses examined whether congruence rates were infl uenced by the use of global as compared to specifi c items, assessment of conversations during the teen’s entire life as compared to the past year, and use of forced-choice as opposed to continuous-response categories. Taken as a whole, …

Method And Apparatus For Controlling Acoustic Signal Bandwidth In An Ultrasonic Diagnostic Imaging System, Jeffrey R. Resnick, Gregory R. Bashford

Biomedical Imaging and Biosignal Analysis Laboratory

An ultrasonic imaging system includes a receive beam former that generates analog receive signals and a scan converter. A receive signal processing path interconnects the receive beamformer and the scan converter, and this processing path includes both an A/D converter characterized by a selectable sampling rate and at least one filter characterized by at least one filter parameter. The filter parameter is selected as a function of the sampling rate to provide enhanced image quality.

Monoclonal Antibody 1a7 And Related Polypeptides, Malaya Chatterjee, Kenneth A. Foon, Sunil K. Chatterjee

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting antibody with immunogenic potential in a multi-step screening process. Also disclosed are polynucleotide and polypeptide derivatives based on 1A7, including single chain variable region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the 1A7 antibody overcomes immune tolerance and induces an immune response against GD2, which comprises a combination of anti-GD2 antibody and GD2-specific T cells. The invention further provides methods for treating a disease associated with altered …

[Book Reviews Of] The Hand Of God: A Journey From Death To Life By The Abortion Doctor Who Changed His Mind, By Bernard N. Nathanson / Nature, The Physician, And The Family, The Collected Works Of Herbert Ratner, Md., Donald Demarco, Eugene F. Diamond

The Linacre Quarterly

No abstract provided.

In Vitro Fertilization: Truth And Consequences, Mark Yavarone

The Linacre Quarterly

No abstract provided.

Information Interface - Volume 27, Issue 5 - November/December 1999, George Washington University, Himmelfarb Health Sciences Library

Information Interface (1976 - 2009)

News and information about Himmelfarb Health Sciences Library of interest to users.

The Public Stake In Biomedical Research: A Policy Perspective, Karen Matherlee

National Health Policy Forum

An introduction to a Forum series on biomedical research policy issues, this paper provides background on the organization and structure of both public and private research entities. It outlines the federal components, from the National Institutes of Health (NIH) to the Department of Veterans Affairs. It also looks at the rapid growth in pharmaceutical, biotechnology, and medical device research and development and the varying responses from managed care plans, practice-based research networks, and contract research organizations. After laying out various tensions in the field, such as competition among disease-oriented advocates, alignment of different priorities, allocation of dollars between basic and …

Tracking Of Physical Activity, Physical Inactivity, And Health-Related Physical Fitness In Rural Youth, Russell R. Pate, Stewart G. Trost, Marsha Dowda, Alise E. Ott, Dianne S. Ward, Ruth P. Saunders, Gwen A. Felton

Faculty Publications

This study examined the tracking of selected measures of physical activity, inactivity, and fitness in a cohort of rural youth. Students (N=181, 54.7% female, 63.5% African American) completed test batteries during their fifth- (age=10.7±0.7 years), sixth-, and seventh-grade years. The Previous Day Physical Activity Recall (PDPAR) was used to assess 30-min blocks of vigorous physical activity (VPA), moderate-to-vigorous physical activity (MVPA), TV watching and other sedentary activities, and estimated energy expenditure (EE). Fitness measures included the PWC 170 cycle ergometer test, strength tests, triceps skinfold thickness, and BMI. Intraclass correlation coefficients (ICCs) for VPA, MVPA, and after-school EE …

Mechanisms Of Gene Transfer Mediated By Lipoplexes Associated With Targeting Ligands Or Ph-Sensitive Peptides, Sérgio Simões, Vladimir Slepushkin, Pedro Pires, Rogério Gaspar, Maria C. Pedroso De Lima, Nejat Düzgüneş

All Dugoni School of Dentistry Faculty Articles

Association of a targeting ligand such as transferrin, or an endosome disrupting peptide such as GALA, with cationic liposome-DNA complexes ('lipoplexes') results in a significant enhancement of transfection of several cell types. Although these strategies can overcome some of the barriers to gene delivery by lipoplexes, the mechanisms by which they actually enhance transfection is not known. In studies designed to establish the targeting specificity of transferrin, we found that apo-transferrin enhances transfection to the same extent as transferrin, indicating that internalization of the lipoplexes is mostly independent of transferrin receptors. These observations were reinforced by results obtained from competitive …

Consistency And Development Of Prosocial Dispositions: A Longitudinal Study, Nancy Eisenberg, Ivanna K. Guthrie, Bridget C. Murphy, Stephanie A. Shepard, Amanda Cumberland, Gustavo Carlo

Department of Psychology: Faculty Publications

The issue of whether there is consistency in prosocial dispositions was examined with a longitudinal data set extending from ages 4 to 5 years into early adulthood (N = 32). Spontaneous prosocial behaviors observed in the preschool classroom predicted actual prosocial behavior, other- and self-reported prosocial behavior, self-reported sympathy, and perspective taking in childhood to early adulthood. Prosocial behaviors that were not expected to refl ect an other-orientation (i.e., low cost helping and compliant prosocial behavior) generally did not predict later prosocial behavior or sympathy. Sympathy appeared to partially mediate the relation of early spontaneous sharing to later prosocial dispositions. …

Ada News - 10/18/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Increased Matrix Synthesis Following Adenoviral Transfer Of A Transforming Growth Factor Beta1 Gene Into Articular Chondrocytes, Franklin D. Shuler Md, Phd, Helga I. Georgescu, Christopher Niyibizi, Rebecca K. Studer, Zhibao Mi, Brian Johnstone, Paul D. Robbins, Christopher H. Evans

Orthopaedics

Monolayer cultures of lapine articular chondrocytes were transduced with first-generation adenoviral vectors carrying lacZ or transforming growth factor β₁ genes under the transcriptional control of the human cytomegalovirus early promoter. High concentrations of transforming growth factor β₁ were produced by chondrocytes following transfer of the transforming growth factor β₁ gene but not the lacZ gene. Transduced chondrocytes responded to the elevated endogenous production of transforming growth factor β₁ by increasing their synthesis of proteoglycan, collagen, and noncollagenous proteins in a dose-dependent fashion. The increases in collagen synthesis were not accompanied by alterations in the collagen phenotype; …

Ada News - 10/04/1999, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Site Visit To Baltimore And Fort Detrick, Maryland — Preparing For A Bioterrorist Incident: Linking The Public Health And Medical Communities, Robin J. Strongin

National Health Policy Forum

As follow-up to the NHPF's February 1999 session entitled "Biological Terrorism: Is the Health Care Community Prepared?" the Forum organized a site visit on October 4 and 5, 1999, to Baltimore and Fort Detrick, Maryland. The site visit provided federal congressional and agency staff with the opportunity to learn first-hand how one local area is preparing for the possibility of a bioterrorist incident. Several themes were stressed throughout the two days, including the following: distinguishing bioterrorism from chemical terrorism, understanding the relationships between various agencies and institutions and their related funding streams, determining how the federal government can …

1999 Scholars And Artists Bibliography, Michael Schwartz Library, Cleveland State University, Friends Of The Michael Schwartz Library

Scholars and Artists Bibliographies

This bibliography was created for the annual Friends of the Michael Schwartz Library Scholars and Artists Reception, recognizing scholarly and creative achievements of Cleveland State University faculty, staff and emeriti

Vital Signs, Fall 1999, Boonshoft School Of Medicine

Vital Signs

A twenty four page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Dentalgram - Vol. 13, No. 10, Loma Linda University School Of Dentistry

Dentalgram

In this issue:

• Student news
• Department news
• News notes

Bovine Herpesvirus 1 Can Infect Cd4+ T Lymphocytes And Induce Programmed Cell Death During Acute Infection Of Cattle, M. T. C. Winkler, Alan R. Doster, Clinton J. Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

Acute infection of cattle with bovine herpesvirus 1 (BHV-1) represses cell-mediated immunity, which can lead to secondary bacterial infections. Since BHV-1 can induce apoptosis of cultured lymphocytes, we hypothesized that these virus-host interactions occur in cattle. To test this hypothesis, we analyzed lymph nodes and peripheral blood mononuclear cells (PBMC) after calves were infected with BHV-1. In situ terminal deoxynucleotidyltransferase- mediated dUTP nick end-labeling (TUNEL) staining of lymphoid tissues (pharyngeal tonsil, cervical, retropharyngeal, and inguinal) was used to detect apoptotic cells. Calves infected with BHV-1 for 7 days revealed increased apoptotic cells near the corticomedullary junction in lymphoid follicles and …

Yale Nursing Matters Fall 1999 Issue 1 Volume 1, Yale University School Of Nursing

Yale School of Nursing Alumni Newsletters and Magazines

"I hope that as you read through this first issue of Yale Nursing Matters, you will realize how exquisitely Yale faculty discharge tile responsibility to advance nursing science while also contributing as leaders in practice and educating the next generation of nursing leaders." - Catherine Lynch Gillis, Dean and Professor

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